UI-LMP RANK TESTS AGAINST RESTRICTED ALTERNATIVES by Michael N, B'oyd Department of Biostatistics University of North Carolina, at Chapel Hill Institute of Statistics Mimeo Series No. 1406 J'u1y 1982 UI~LMP RANK TESTS AGAINST RESTRICTED ALTERNATIVES by Michael N. Boyd -- A Dissertation submitted to the faculty of The University of North Carolina at Chapel Hill in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Biostatistics Chapel Hill 1982 Approved by: Advisor Reader ~_ ).-/". (~,\. Reader {' t u- \ ,- r) ~ /i /: > - - V, MICHAEL N. BOYD. UI-LMP Rank Tests Against Restricted Alternatives (Under the direction of PRANAB KUMAR SEN.) v In their book, Theory of Rank Tests, Hajek and Sidak (1967) formulate a general theorem on locally most powerful (LMP) rank tests for the one and two-sample location problems as well as the problem of simple regression. However, when testing against ordered alternatives one encounters a family of mUlti-parameter probability densities and no general LMP rank test exists. It is desirable to extend this local optimality property to the multi-parameter setup. Following Sen (1981), the union-intersection (UI) principle of Roy (1953) is used to extend the theory of LMP rank tests to a broad class of mUlti-parameter alternatives. The test against ordered alter- natives in the one-way layout is derived as a special case. The results of this test correspond to those of Chacko (1963) when logistic scores are used. This implies that Chacko's test is optimal when the under- lying distribution of the data is the logistic distribution. The problem of extending the UI-LMP rank test method to tests against ordered alternatives in the complete blocks design is considered. Three procedures are examined. tests which use within block rankings. The first procedure concerns The second and third procedures concern tests which use weighted and aligned rankings, respectively. In addition, methods for the analysis of covariance, and analysis of the two factor experiment are presented. ACKNOWLEDGEMENTS Having Dr. P.K. Sen as my advisor has been the most rewarding experience of my academic career. I also wish to thank the other mem- bers of my committee, Dr. Dana Quade, Dr. Craig Turnbull, Dr. Bert Kaplan, and Dr. Roger Grimson. They have indeed been very helpful and supportive. During my time as a graduate student in the Department of Biostatistics, I have been supported by grant T32 ~lli 15131 from the Center for Epidemiologic Studies, National Institute of Mental Health. Special thanks are due to my wife Beth for making these past four years in Chapel Hill the happiest years of my life. Thanks also to our son Kevin who arrived just in time to help me finish my computer work. Finally, I wish to express sincere thanks to Jackie O'Neal who did an excellent job of typing this manuscript. iii CONTENTS ACKNOWLEDGEMENTS 1. INTRODUCTION AND LITERATURE REVIEW 1.1 Introduction. ·1 1.2 Tests Against Ordered Alternatives for the One-Way Layout . . . . . . . . . . . . . . . . . . . . ·1 Tests Against Ordered Alternatives for the Two~Way Layout . . . . . .... . . . . . . . .6 1.4 Nonparametric Methods for Higher Order Layouts. .11 1.5 Relevant Methods. · 14 1.6 Proposed Research .16 1.3 2. OPTI~~L RANK TESTS FOR ORDERED ALTERNATIVES IN A GENERAL LINEAR MODEL -- 2.1 Introduction. .18 2.2 Theory. .19 2.3 Example .24 2.4 Asymptotic Nonnull Distrubtion of TN' .29 2.5 Local Asymptotic Power and Efficiency .34 2.6 An Application to Mental Health Data. 2.7 An Example Involving Two Factors . . ·44 .47 2.8 Testing for Order in an Analysis of Covariance. .51 ') 0 .... Example .53 -' 3. 2.10 Testing for Order in a 2 Factor Experiment. .56 2.11 Summary .57 OPTI~~L . . . . . .... RANK TESTS FOR ORDERED ALTERNATIVES IN A COMPLETE BLOCKS DESIGN .59 3.1 Introduction. 3.2 Within Block Rankings 59 3.3 Example . . . . . . . .66 3.4 Asymptotic Power and Effeciency Considerations. 69 3.5 Weighted Rankings 70 3.6 Example . . . . . 77 3.7 Aligned Rankings. .80 iv .. . Example 3.9 Testing for Order in an Analysis of Covariance. 3.10 The 2 Factor Experiment Replicated in Complete Blocks. 3.11 Summary 4. .85 n . .88 .89 MONTE-CARLO RESULTS 4.1 Introduction. .90 4.2 Simulated Experiments for the One-Way Layout. .90 4.3 Simulated Experiments for the Complete Blocks Design 97 Summary 103 4.4 5. .82 3.8 RECOMMENDATIONS FOR FUTURE RESEARCH 105 REFERENCES v CHAPTER 1 Introduction and Literature Review Introduction 1.1 When data are collected for the purpose of comparing different treatment effects, a priori the investigator may hypothesize a specific ordering of these effects. In this case a procedure which tests the hypothesis of equal treatment effects against the alternative that not all treatment effects are equal is not appropriate. For instance, consider a clinical trial in which different groups of patients receive 'e varying amounts of a drug. The alternative hypothesis may be that the effect of the drug increases with the amount. A standard analysis of variance F-test will not be sensitive to the ordered alternative. A more powerful test which takes this ordering into account is needed. Specific procedures depend on the design of the analysis. cally the problem is to test the null hypothesis, were h H = ]Jl a ]J. 1 ~ ... . IS Basi- HO=]Jl = ... =]Jk . . t h e 1. th treatment mean, agaInst t h e or d ere d a 1ternatIve ~]Jk where the subscripts 1 to k are arranged according to the prespecified alternative, and at least one inequality is strict. 1.2 Tests Against Ordered Alternatives for the One-Way Layout An early attempt to solve the problem of testing against ordered alternatives in the one-way layout was made by Jonckheere (1954a). Let k be the number of samples. The test statistic, J = L i <j u.. , 1J is 2 the sum of the k(k-l)/2 comparing treatments i Mann-Whitney statistics and j. If J for U .. , i<j, I) is too large, the hypothesis of equal treatment effects is rejected in favor of the ordered alternative. Tables exist for evaluating the significance of (1971)). J (See Odeh However, these tables are limited and may not exist for a given number of treatments and sample sizes. For large samples. J is approximately normally distributed, the approximation being better for large values of the i th min(nl, ... ,n ) k where n. 1 is the sample size for sample (see Hollander and Wolfe (1973)). The exact test is powerful when the treatment means are monotonically increasing. This test has been generalized by Patel and Hoel (1973) to the case where observations are subject to arbitrary right censorship. Another approach to solving this problem was taken by Bartholomew (1961) who makes use of parametric theory. derived under the assumption of normality to ordered means. One such test, the -2 X Likelihood ratio tests are te~t the equality of test, is derived in section 3.2 of Barlow, Bartholomew, Bremner, and Brunk (1972) . Let x. 1 be the . th 1 sample mean. Population variances, associated with each sample are assumed to be known. lihood estimates of k k under J.J. 1 I w.x./ I w., and i=l 1 1 i=l 1 ~ ~, i = 1, ... ,k where j.1~ ~ = 1 1 A 2 o. , 1 The maximum like- • H are ~. = J.J, for all i, where O 1 -2 w. = n.o. Under H the m.l.e. 's are III a is the isutonic regression of x .. 1 Under 2 Ho all populations have the same variance a. The likelihood ratio -2 k 2 2 test rejects HO for large values of X = I n. (0~-0) /0. A k i=l 1 1 method for calculating the 0~ involves amalgamating some of the ori1 ginal k groups into subsets and is given in Barlow et al. (1972). e- 3 Under k L pC-Q"k)pr(X;_l ~ c), c > O. and 1=2 where P(t,k) is the probability that the isotonic -2 ~ H Pr (X O k -2 Pr (X = 0) = P (l, k), k c) = ~* lJ. regression function takes exactly 1 is a chi-squared random variable with P(1,k) t t - 1 degrees of freedom. multivariate normal population with mean vector known variance matrix i Values are tabulated in Barlow et al. (1972). Now consider a multivariate approach to this problem. HI: 8 2 X_ t l distinct values, and ~ A, 0 (i=l •... ,k) Given a 8' = (8 , ... ,8 ) and k l H : 8 = 0 vs O i on the basis of the sample x(l), ... ,X(n). it is desired to test l Kudo (1963) proposes the test statistic (X-8)} ;(2 = n(X'A-lX- min (X_8)'A8.20 2 1 X is the sample mean vector, Calculation of X where involves finding the minimum of the quadratic form subject to the condition 8. 1 ~ 0 for all 1. l (X-8)'A- (X-8) -2 The distribution of X is discussed in Kudo (1963). The results of Kudo may be considered as a generalization of those of Bartholomew. H Under a should the differences Y be positive and can be estimated by the successive differences X2~Xl'" Y- ) k l "Y - k l = xk-x _l , k The variance-covariance matrix of can be calculated when the common variance of the known. -2 X duced by Chacko (1963), is calculated as follows. observation in the r.. 1) = (Y ",·, l samples is Then the procedure of Kudo may be applied. A nonparametric version of Bartholomew's for all k I i. i th sample. test statistic, introLet x .. 1) i = I , ... ,k, .i = I •... , n 1. . th be the where ) n.1 = n The observations are ranked from smallest to largest where is the rank of x.. 1) among all the are now cal culated from the ranks. N observations. The The form of the statistic is O*'s 4 -2 Xrank = (12/N(N+l))In.1 (P~1 _ (N+l)/2)2. Note that in the parametric case the estimates pooling of adjacent within sample means. o~ 1 depend on some The estimates for the nonpara- metric case are different in that they are calculated from ranks obtained in an overall 1 to N ranking. Hence, these ranks depend on all the observations, not just separate ranks within each sample. Under -2 Xrank H the limiting distribution of O -2 X the null hypothesis distribution of Bartholomew's et al. (1972)). -2 The is the same as (see Barlow test is appropriate when the alternative X states that the treatment means are monotonically increasing. -2 X rank test does not depend on the assumption of normality. -2 Xrank treatment means do not increase linearly, the The When test will be more powerful than Jonckheere I s test (Chacko (1963)). The above methods have included specific tests against ordered alternatives. Let tests. combined t.;(i,j) = 1 v i th and J.th ~(i,j) = O. v Let the combined wise Puri (1965) has described a family of . th 1 if the v n . T ~~) J 1J 1J .th 1J I I i=1 j=i+l n.n.h .. , 1 J 1J X. 1 v th observation and otherwise smallest observation from x. observation and other- J n.+n. where n.+n. = 1 I J E (i ,j) n (i, j ) v=l v v k rank smallest observation from the samp l es '1S an J satisfying certain restrictions. k-I th samp l es '1S an n(i,j) = -1 and v n(i,j) = o. v Denote he. = T~~) + T~~) 1J and if the k-sample n.l~~)::: 1 I 1 1J v-I where the E(i,j) v J are constants Then the test statistic is V= 5 When test. E(i,j) = v/(n.+n.) v . 1 ) the test is equivalent to Jonckheere's Asymptotic normality and the asymptotic distribution of this family of statistics are discussed in Puri (1965). Tryon and Hettmansperger (1973) follow the approach of Hogg (1965) to extend Puri's family of statistics. Weighting coefficients are k k-l included to form T = I I a .. T .. where T..1J is any Puri staN i=l j=i+l 1) 1J tistic and a .. ;:O: O. 1) Consider the subclass of statistics (TlZ,TZ3, ... ,Tk_lk)' The authors prove that for each statistic TN there exists an equivalent v k k-l statistic T* where T* = \ a T and a = I I a .. , N L v vv+l N v i=1 j=v+l 1J v=1 v = 1,Z, ... ,k-l. Thus computation for k - 1 statistics rather than (k ) Z is required. TN - TN ~> 0 of T* N The statistics are equivalent in the sense that and the Pitman efficienty when standardized under with respect to is one. In another paper, Shorack (1967) has derived the results of Bartholomew and Chacko as special cases of a theorem which represents a generalization of Bartholomew's result. Chacko's test is also extended to the case of unequal sample sizes. Finally, three more methods will be briefly mentioned. Hogg (1965) considers a parametric procedure similar to that of Jonckheere (1954a). The test statistic is I i<j (x.-x.), J and the differences may be 1 weighted. Another method is similar to that of Sen (1968). Here the test statistic is based on correlating treatment means with predicted treatment rankings. Lastly, Wallenstein (1980) suggests calculating a test statistic based on summing over k - 1 adjacent pairs of two-sample one-sided Smirnoff-type statistics. 6 1.3 Tests Against Ordered Alternatives for the Two-Way Layout This section is concerned with four types of procedures for the two-way layout. The procedures include within block rankings, aligned ranks, the tests of Hollander (1967) and Doksum (1967), and weighted rankings. The earliest paper was again written by Jonckheere (1954b). sider a complete blocks design with k treatments and n Con- blocks. Observations are ranked within blocks, and the test statistic is the sum of the Kendall coefficients of correlation between the predicted ordering of the treatments and the ranking of each of the n blocks. Jonckheere derives the sampling distribution of the test statistic and shows its large sampl e distribution to be normal. Page (1963) uses Spearman rank correlation to calculate a test statistic for the completely randomized block design with k treatments. Let L = I treatment in the .th 1 ordered alternative. large samples L R.. 1J block. (P. I Pl"",Pk are is the within block ranking of the jth j=l the predicted ranks and blocks n k and n R.. ) J i=1 \vhere 1J A large value of L reflects the Exact tables are included in Page (1963). For is asymptotically normal. Jonckheere (1954b) also considers the case when there are one or more observations per cell and the number of observations per cell is the same within each treatment group. Here the tratments are ordered and assigned appropriate tied rankings based on the number of observations per cell, e.g. if th 2 r is the number of observations per cell th treatment group then the r treatment will receive r-l 1 . predicted rank "2 (2 + 1) + I 2.. Observat ions are ranked wi thin r i=l 1 for the r e' 7 each block and the test statistic is again the sum of the Kendall coefficients of correlation between the predicted rankings and the . observed rankings within each block. Page's test is extended by Hettmansperger (1975) who considers the case of more than one observation per cell. k L n L n is the rank In I) . . , where R.. L L j R.. 1J. I). i=l j=l is the number of observations in the (i,j)th cell. R.. In .. j=l i=l cell sum and n .. IJ T::: j The statistic k 1). I) = The null hypothesis is rejected for large values of T which is also shown to be asymptotically normal. A competitor of Page's test has been proposed by Pirie and Hollander (1972). o_ define Let R.. I) be the within block ranking of D~ to be the expected value of the ) a random sample of size jth X.. , I) and order statistic of from the standard normal distribution. n k k The test statistic is W = L I j DR ..• For k~4 the normal n i=l j:::l I) scores technique is shown to be more efficient than Page's test for k many alternatives, but not in general. Pirie and Hollander (1972) include tables for the null distribution of approximation is given where k {nk(k+I)/12} EO = (W ) ::: 0, n W, n and the normal var {W } ::: and 0 n L (D~)2. j=l ) More literature for the two-way layout is provided by Shorack (1967) who extends the procedures of both Bartholomew and Chacko. In the para- metric case, likelihood ratio tests are derived by minimizing the sum of • amalgamated squares for the desired effect, subject to the constraint specified by the ordered alternative. observation R. = J Ij r .. /1 I) x .. I) For the nonparametric case, each is replaced by its rank in the where I .th 1 row. Let equals the number of levels of the first factor. 8 R. 's to obtain m dis- An amalgamation process is applied to the tinct quantities m RIt J, ... ,R1t J. (12Ij(J(J+l))) i~l t i (R The test statistic is m 1 J 2 ] - (J+l)j2) , Iti tion is discussed by Shorack (1967). denoting the i th .th block and X.. based on a sum Y be a random variable IJ treatment combination in a random- J ized complete blocks design with Let . and its asymptotic distribu- HOllander (1967) introduces a test statistic of Wilcoxon signed-rank statistics. -2 X = r n blocks and k Let treatments. Y (i) R(i) is the rank of y(i) in the ranking of = Ix. - x. I and uv IU IV uv uv n I (i) y(i), ... ,y(n). Also let T = I R \jJ (i) where 1/!uv = I if uv uv uv uv uv i=] X. < X. and 0 otherwise. Then Y = I T Hollander (1967) lU IV u<v UV discusses the asymptotic normality of Y and notes that Y is neither distribution-free nor asymptotically distribution-free. A test similar to that of Hollander is proposed by Doksum (1967) . Using Hollander's notation define random variables U uv = T uv I 1jJ (i) . uv . I 1= (U - U ) where U. = u. v. J u<v This test statistic is asymptotically normal and asymp- Doksum considers the statistic n -I n I U ... i=l IJ totically distribution-free. Puri and Sen (1968) generalize the results of HOllander to a Chernoff-Savage class of tests. i = I, ... ,n. zen) = I uv,o. Let tion V n a or th \jJ*(x) I u<v IU Consider the random variables 0 as the o. th T(n) uv X* , and T(n) uv - 1jJ(-x), x ~ IV = n- 1 IE no. Zuv,o. (n) 0, and 0 no. are asymptotically normal. if where Ix* I i,uv is the expected value E order statistic of a sample of size = 1jJ(x) - X. , u < v = I, ... , k, smallest observation among comes from positive or negative of the = X. X~ 1,UV n x < o. from a distribuThe test statistic • 9 Pirie (1974) has made a comparison of the above tests, which he refers to as tests based on among block rankings or tests based on within block rankings or as a measure, Pirie concludes that W-tests. W-tests A-tests, and Using their A.R.E. would more often be pre- ferred to A-tests. Another procedure for the two-way layout involves using aligned ranks. Sen (1968) considers such a class of aligned rank order tests. Define the aligned observations as k Y.. = X.. - X. IJ 1J 1 where X. = 1 I X.. /k, i = 1, ... , n; j = 1, •.. , k . Let R.. be the rank of Y.. j=11 J IJ IJ among all nk = N observations. For every N, a sequence of rank functions, ·e £N = (E N1 ,·· .,E NN ) is defined. Define z(j) = 1 if the a th smallest observation among the N Na .th values of the Y.. 's is from the J treatment, o otherwise. A 1J where class of statistics is defined by N n -1 \' !... ~ k (j-~(k+I))TN ./{o2(p )k(k2_1)}~ T* = (12n) 2 N ,J n k j=l 1 n o2(p ) = {n(k-l)})1 {ENR .. - ENR . }2, and ENR . = n I I where k . = n, J Th e statistic for testing against E Z(j) . - 1 k Na Na ' J - , .... , . a=l ordered alternatives is -1 T k L j=l ENR .. ' IJ Note that 1. i=l J= IJ 1. T* is asymptotically standard normal. N De (1976) extends the methods of Sen by employing the unionintersection principle to formulate a test using aligned ranks. Fol- lowing the notation of Sen (1968), De defines a reference class of test statistics k St>.,N = I b. = 0, j=l J and I b. (TN"-EN)/{var p j =1 J .- .J n II II b. =1 J (TN"-EN)l}~ J J where Sb N .:. , N(0,1) . ~, A test against the ordering of treatment effects is derived using the VI principle where the test statistic and B is a 10 U 8b where 8 = {~: 8 ~ ". ~ 8 , i k bEB .th with at least one inequality being strict}, e. being the 1 treatk-l 1 ment effect. The lim PH {Q> c} = I P{X9- > c}P(9-,k) and the weights a 9-=1 P(9-,k) are tabulated in Barlow et al. (1972) and Chacko (1963). Note set of values of that b such that Q is related to the 8 c ~esults of Bartholomew, Chacko, and Shorack. Quade (1979) proposes a method of weighted within block rankings. Assuming blocks to have equal underlying variability, those blocks in which the observed variability is greater are more likely to reflect true ordering of treatment effects. Such blocks are termed more credible and are assigned greater weight. Using this technique infor- ation is gained by comparing observations among blocks as well as within blocks. Using the above weighted rankings procedure, Silva (1977) generates a family of distribution-free tests by combining different measures of variability, different sets of block-scores, and different sets of treatment-scores. Test comparisons are made using the expected significance level method (see Silva and Quade (1980)). Salama and Quade (1981) extend the procedure of Quade (1979) to tests against ordered alternatives. The test statistic is w = n n i~l bQiCi/i~l b i where Ci is the correlation between the predicted th and observed ranking within the i block, Q. is the rank of the 1 i th that block with respect to credibility, and the 0::; b ::; ... ::; b . l n Kendall correlation. bls are weights such Distributions are obtained for both Spearman and Comparison of tests for small experiments is undertaken using the expected significance level method of Silva and Quade (1980). W is shown to be asymptotically normal when 11 as n + and 00 0< V(C) < where 00 V(C) is the vari- ance of the correlation statistic. Skillings and Wolfe (1977) present a class of tests based on r weighted sums of block statistics. block. Let T. be a statistic on the I the b i '",.> are nonnegative weighting constants. the b are based on the maximum A. R. E. of I S th n Then the test statistics are of the form i i T: I b.T. where i:l 1 I Criteria for selecting T. Different scoring schemes may be used in different blocks to form the weighted sum in an optimal way. This might be done when distributional forms are thought to be different in different blocks. In a related paper, Skillings (1978) considers an application of Jonckheere's test statistic in block designs with unequal scale paran meters for the blocks. Let Jonckheere's statistic be JK*: Skillings proposes the statistic nonnegative weighting constants. the b. Ii 1 I JK .. i:l b. 's n I where the are I b.JK. 1 1 1 i=l The main concern is the selection of JK = in the unequal scale situation, but assuming distributional forms to be the same in all blocks. The to IS JK* b. 's 1 are selected to maximize the A.R.E. of under translation alternatives. shown. with respect Asymptotic normality of JK To adaptively select the weighting constants Skillings suggests estimating the 1.4 JK ~onparametric o. 's and using them to I est ima te the b. I is. Methods for Higher Order Layouts First consider a procedure for testing for main effects and interaction proposed by Reinach (1965). m and p Given two factors levels respectively, let the k = mp A and B at treatment combinations 12 be replicated times, and let c . .) th ( 1, J replication of the j=l, ... ,p; and ranked from I k, r observations of the h th ijh be the observation in the ijh treatment combination where h= l, ... ,c. to x h th i=l, ... ,m; Within each replication, values are being the rank of replication. x.1J"h among the k Reinach defines test statistics for the main effects and their interaction which are asymptotically disstributed as chi-squared random variables. A second method using orthogonal contrasts is also described. Crouse (1968) proposes a method for testing any effect indepenm factorial experiment with an dently of the other effects in a 2 equal number of observations per cell. The strategy is to reduce the problem of testing for any effect to a two-sample problem and then apply existing nonparametric two-sample tests. are similar. Tests for interaction Assuming the usual side conditions, independent random variables are created by summing in such a way as to make all but the desired term drop out of the model. Then a two-sample tests of loca- tion may be used. This techniq~e is used by Mehra and Sen (1969) who describe a class of conditionally distribution-free tests for interactions in factorial experiments. Consider a replicated two factor experiment with one observation per cell. factors are at levels p tions results in a model and Z. = ~l There are q. r ~ + Let among all replicates and the two The use of intra-block transformaE., i = 1, ... ,n, ~l interaction parameters and an error matrix. dimension n containing only These matrices are of p x q. r ijk denote the rank of N = pqn Zijk' j=l, ... ,p, k=l, ... ,q, aligned observations. A sequence of real numbers 13 UN 1"" ,I N N} , ' where TN , J'k n, . + n. IJ. L N = is defined. Let J = n , and IN = (TN 'k) ijk ,J N,r, 'k n n . IJ -1 -1 n Also, TN 'k = n n (n, 'k - n, kijk = n .jk· ,J '1 IJ 1. 1= i=l L L ). The test statistic for testing for interactions is P q 2 \' \' 2 2 -1 [n/o (PN)].L L {T * 'k} where 0 (P ) = (n(p-l) (q-l)) N N 'J P q J= 1 k =l 1.. = \' L \' L (n"k- n , k-· n ., j=l k=l IJ 1. I). + n. 1 .. 2 ). The cOnditional distribution of LN under the hypothesis of no interaction converges in probability to 2 X(p-l(q_l)' Mehra and Smith (1970) also propose tests for the absence of interaction in a factorial experiment. metric estimation of contrasts. Their work involves nonpara- They claim their procedure to possess more robust A.R.E. than the method of Mehra and Sen (1969). In anotjher paper, Sen (1970) considers a class of nonparametric procedures for testing the various main effects and interactions in a m factorial experiement replicated in 2 n blocks. Intra-block trans- formations are used to obtain aligned observations. This procedure incorporates the use of some well known rank statistics such as the sign test and general scores test. Extensions to confounded designs are considered. MacDonald (1971) also considers using ranks in the analysis of a m 2 . experIment. The anlysis is based on the use of orthogonal con- trasts of ranks where observations are ranked from each block. 1 to m 2 within It should be noted that the rankings are interchangeable only'when all main effects and interactions are equal to zero, the rankings being sensitive to all parameters in the model. Hence, this 14 test is not efficient for sub-hypotheses, only the full hypothesis that all main effects and interactions are zero. Relevant Methods 1.5 Rank tests are valid for a broad class of distributions. a general class of tests involving different rank scores. question is what score should be used. blem is to look at local optimality. :!,est~, Consider The basic One way of solving this proIn their book, Theory of Rank v Hajek and Sidak (1967) formulate a general theorem on locally most powerful (LMP) rank tests. tests is rarely possible. Exact evaluation of power for rank For this reason LMP rank tests have been developed. Consider an indexed set of densities qo E H. A test is LMP for is uniformlly most powerful at level {Q6' 0 < ~ < s} ~ H against for some s > a {q~}, ~ 2 0, and assume > 0 at some level for H against a if it K s o. v Hajek and Sidak discuss the one and two-sample location problems as well as the problem of simple regression. However, when testing against ordered alternatives one encounters a family of mUlti-parameter probability densities and no general LMP rank test exists. It is desirable to extend this local optimal ity property to the mu 1ti -parameter setup. A method for doing this is proposed by Sen (1981) who uses the union-intersection of LMP (UI) principle of Roy (1953) to extend the theory rank tests to a broad class of multi-parameter alternatives. As an example consider the f. (x) = fee 1 -6 ' c. 2 ~ ~l (x-~'c.)) ~l~l ' k-sample i=1, ... ,n, location-scale model where are the p.d.f.'s of n e· 15 independent random variables. The vector of unknown parameters, and the thesis, H : O Q, ~ = are known vectors. c. ~l is a vector t:.' = (t:.' t:.') ~l'~2 The null hypo- is tested against appropriate alternatives. To formulate the alternative hypotheses consider sets rEL:' and let f=tir, Ht:.y: I, and U Ht:.y represent the alteryEf principle is used to construct the test t:.;:>:O, Ht:.f = ~ native hypotheses. statistic T* n = UI The sup{T*(y): Y E flo n ~ Further detail will be presented in the next section. The union-intersection principle of test construction devised by Roy (1953) is covered in Morrison's book (1976). Primarily intended for multivariate tests, it may be extended to other setups. x~ . . . ." Np (~,~), f'Oo..) elements. a' is any nonnull p-component row vector of real "" ~'~ ~ N(~'~,~'E~), Then tance region a and Let t-critical 2 t2(~) ~ t a/2,N-l and a univariate test with accep- may be performed where t a/2,N-l is value. The original multivariate hypothesis of for all nonnull only i f ~. ]J ~ ]J ~O is true if and Acceptance is equivalent to accepting all univariate hypotheses for varying acceptance region is the intersection, = 3. The multivariate 2 2 n [t C.~) ~ta/2 N-l]' a ' which 2 is the same as specifying t h at max t 2(),,< ~ - ta/ 2 N-1 . Th"' 1 S I S the a ' Hotelling test which is also the likelihood ratio test. In general, the VI test and likelihood ratio test are not the same. When using the function. VI principle it is necessary to maximize some For tests against ordered alternatives the function must be maximized subject to inequality constraints. of nonlinear programming. This involves the use 16 Consider maximizing subject to (KT) necessary conditions for the above problem are: i, and f,(:) sQ. ~ ? ~ and g(x) :::; O. ~ to be a stationary point of - ""AVg(x) ::: ,...., 0, A.g.(X):::O, 0, V'f(x) ,.... "" 1 1 Note that ~ V'f(~) ::: is convex for all 1. for all ~ [df(~) ' oX l necessary conditions are also sufficient if gi (2S) The Kuhn-Tucker ~ ... , f(2S) of(~) ) ox n . The above is concave and This material may be found in Taha (1976) . The purpose of this work is to develop new statistical theory in the area of nonparametric tests against ordered alternatives. Exist- ing literature has been reviewed which concerns testing against ordered alternatives in both one-way and two-way layouts, the use of weighted rankings in block designs, and rank tests for higher order layouts. Chapter 2 is concerned witb constructing tests against ordered alternatives in the one-way layout. This problem is attacked using the union-intersection-Iocally most powerful rank test methodology of Sen (1981), and literature relating to this topic is also reviewed in this chapter. A procedure for testing for order in the analysis of covariance is described in section 2.8. This method involves applying the union-intersection principle to a procedure presented in Puri and Sen (1971). The results of Chapter 2 are extended to the complete blocks design in Chapter 3. Extensions to tests which use within block rank- ings, weighted rankings, and aligned rankings are considered. method for testing against ordered alternatives in a two factor Also, a e- 17 experiment with no interaction is described in section 3.9. Finally, the last chapters deal with some numerical work concerning asymptotic power and efficiency, and recommendations for future research. -e CHAPTER 2 Optimal Rank Tests for Ordered Alternatives in a General Linear Model 2.1 Introduction This chapter uses the UI-LMP rank test methodology to construct tests against ordered alternatives in the one-way layout. Applying this method tn extend the results of De (1976) to the one-way case, the solution obtained is the same as that of Chacko (1963). used the UI principle De has to construct tests for the two-way layout while Chacko has used an ad hoc procedure to extend the results of Bartholomew (1961) to the nonparametric case. use any optimality criteria. Neither Chacko nor De Following the theory of Sen (1981) the UI principle is used to introduce some local optimality properties. Hence, this work may be viewed as a justification of the results of Chacko on the grounds of local optimality as well as an extension of De's results to the one-way layout. The optimality properties of this family of tests are derived from the choice of scores for the rank statistic. Basically, a prob- ability density is chosen from which the scores are determined. a rank test is constructed. Then While the scores depend on a certain den- sity, the test is valid for a broad class of alternatives. To be more general, a linear model which includes the one-way layout as a particular case will be considered. e· 19 2.2 Theory be N independent random variables with continuous N distribution functions F , ... ,F and continuous probability density I n Let Xl' ... ,X f , ... ,f . functions I Consider the multiple regression model N f, (x) = f(x-a-c~l::,) (1) 1 where ~l~ , 1 = I, ... ,N is a vector of unknown parameters, and the of known constants. H : k = Q, O c. ~l are vectors It is desired to test the null hypothesis, against appropriate alternatives. problems the vectors and I::, c. ~l In a majority of may be chosen in more than one way. However, this non-uniqueness of choice should not be a concern as the ultimate test procedure remains invariant under such a choice. ·e general, the alternative hypotheses are of the form and Hl::,f = U yEf where the sets H6y r and H f::,X In : 8 = f::,y. f::, ~ A-' ~ 0 depend on the speci- fic alternative. Following Sen (1981), the calculation of scores to construct locally optimal rank tests is the same as in H§jek and Sid§k (1967). f(x;~) For a given density (2) £(x) = let {f(x;Q)} -1 Cd / a8)f(x;Q) _ -f' (x) • 1 = g(x)l f (x) - where (a/3Q)f(x;Q) is the vector of partial derivatives taken with respect to each of the parameters and evaluated at zero, f(x;Q) the density function with all parameters set equal to zero, and g(x) = -f(x)/f(x). Define , is 20 ¢(u) (3) where F f(x;Q). g(F-l(u)) , Then the scores are defined by ::: E¢ (lJ ") N'1 where O<u<l is the distribution function corresponding to the pdf (4) n = U NI < .•. < U NN from the uniform tistics let are the ordered random variables of a sample of size (0,1) distribution. X. be the rank of ~i i=l, ... ,N , Ties are disregarded since the tor of rank statistics IN 1 To construct the rank sta- among Xl' ... ,X N for are assumed continuous. F. 1 i = 1, ... ,N. The vec- consists of elements corresponding to the elements of the unknown parameter vector and is defined by ~ N TNm (5) where p and hence, T = I m= l, ... ,p i=l is the dimension of C .• 1J ~. Note that can be replaced with c .. 1J aN C. J = ° by definition, in the definition of Nm· ~~en the scores are derived from the true underlying distribution of the data the resulting rank tests will be optimal. For instance, if the data come from a normal distribution, and normal scores are chosen, then the optimal rank test will be constructed. Using the above method, logistic, normal, and exponential scores have been determined. Logistic or Wilcoxon scores are of the form Chacko (1963) uses these scores. aN ( 1. ) of = E( Z Ni)' h were ZNi aN(i) = ~;l - l. The normal scores are of the form . . . f rom a samp I e IS t h e 1. th ord er statIstIc N standard normal random variabl es. Teichroew (1956) has tabled 21 these values for are 0 N::; 20: Finally, the exponential or log rank scores i ~ f th e torm a ( 1. ) N - I 1 - 1. N-.i+l j=l Constructing the UI-LMP rank test involves forming the statistic r'IN on r r and maximizing it over all 1:' rEI> Note that for every fixed ylO ~ Y where ~N~ o E{XI!NIHo} = 0 is defined as follows. ~N where subject to certain restrictions E -C . -1 Nm:; N and Let N I i=l c·1m m=l, ... ,p. Then N (7) I C N i=l ~l (c. -eN) (c. -eN) ~1 ~ ~1~, I and ·e N = (N_I)-l) [i:;N Ci )) [~N(i)J I = ~ ill where 1=1 (8) Finally, (9) Before considering the UI-LMP rank test against ordered alternatives, tests against orthant alternatives will be examined. The fol- lowing restrictions are placed on the alternative hypothesis: (10) r = {r: r ~> ~ with r' r > O} The problem now becomes one of maximizing y'T ~ ~N subject to the 22 constraints y ~ '" and 0 y'D y :; constant. f""o.J f"o.,I This problem has been f"otJN,...., solved byChinchil1i and Sen (1981 a,b) who make use of the KuhnTucker theorem. Following the notation of Sen (1981), let P = - {1, ... ,p} and (0::. a ::.. P) . a a be the complementary subset. 2P For each of the sets a, IN be any subset of Note that and . .QN are partitioned as , rT' T') IN = '~N(a)' ~N(a) , (11 ) and QN = (12) ~ ~N(aa) D - ~N(aa) D-J D-- ~N(aa) ~N(aa) Let k (a) be the number of elements in the set dimension of k(a) x D ~N k(a), etc. For each T (13) k (a) is (aa) ~N(a) T ~N(a) For and a = 0 D* ~N(a) define = QN' ~N(aa) v T ~N(a) k (a) , 0 a, 0* (a) = D ~N x c so that the the dimension of a c -1 - D a - D D - ~N(aa) is define P, -- T - ~N(aa)~N(aa)~N(a) - D = 0, - D-1 - - D - ~N(aa)~N(aa)~N(aa) and for a=P define v _. T ~N(a) IN The or -LMP statistic is given by (14 ) where I(A) stands for the indicator function of the set A. both indicator functions are nonzero for only one of the above expression tells us which T ~N(a) to use. Note that T ~N(a) so the e 23 The asymptotic distribution of a: 0 cae P, every The rea) T* N is as follows. First, for define are the products of certain normal orthant probabilities and they sum to one. Then the (16) where is a chi- squared random variable having freedom. Note that for the null set probability 1 k(a) = 0 and k (a) 2 Xk(a) degrees of ~ x . h W1t by definition. To construct UI-LMP rank tests against ordered alternatives set -e (I 7) where at least one inequality is strict. i; = Ey and g Consider the transformation where 1S a nonsingular p x p matrix of the form 1 0 0 -1 1 0 0 -1 1 (19) :1 1 0 0 -1 1 Thus, for every r E £. Now I r!N may be written as 24 f I~ !N' and the solution for the orthant alternative pro- blem may be used to solve the ordered alternative problem after transformation. y'T use ~ ~N Instead of working with ~ ( E,)-l =- E* , ~ ~ 2.3 Example Setting D =- ~E*D~N~ E*'. and its variance ~N An example will serve to illustrate the preceding methods. Con- sider a one-way layout with 3 treatments and 7 observations per treatment. The observations are ranked from smallest to largest, and the overall ranking appears below. Treatment Ranks 1 1 10 2 4 16 8 3 2 13 19 6 15 7 18 9 3 5 21 17 12 11 20 14 The model of interest is F.(x) =- F(x-8.) J J (1) where 8. J j=-1,2,3 is the effect of the jth treatment. (2) Now the model may be expressed as where , j=-1,2,3. Define 25 £1 £8 H a : o:s; 11 21 :s; 6 31 , (0,0) , ::: := ::: £14 ::: (1,0)' ::: £21 := (0,1) 6 = 0 £15 ::: It is desired to test ::: ::: H : 6 O 21 := £7 31 I against the ordered al ternati ve Alternatively, the model may be defined as where £1 _. ::: ::: £8 (0,0)' £7 = £14=(1,0)' £15 = ... = £21 and ·e H : O lin = 6 32 = 0 := (1,1)' is tested against H a : 112l ?: 1132?: 0, results will be the same for both of these models. O. The Note that a model containing 3 parameters, one for each treatment, will result in a sinN gular variance matrix QN L aN(i) = 0 implies i=l (T , T , T ) are not N2 N3 N1 since the fact that that the set of 3 treatment statistics linearly independent. Logistic scores have been chosen so that the end result may be compared with Chacko's test. ~lN(i) = [~N+l ,-' 1 ~- 'N+l 1)' The scores are = [i-ll 11' i-11] , 11 ' i=1, ... ,2l. Calculate 10 IT' and 21 23 aN(R.) = 11 i=lSNl L 26 To compute the variance matrix QN' first calculate and .'iN TIlen 1 -11 2 66l:1 49 o ~N ~ , and IN 10 = [IT' 23) IT t . The next step is to apply the transformation which changes this problem from one of testing against the ordered alternative to one of testing against an orthant alternative. H : O:s; L1 :s; L1 , a 3l 21 L1 31 - .6 21 ~ O. which is the same as testing that The needed transformation matrix is E = since and The alternative hypothesis is C~ TI L1 21 ~ 0 and 27 Now IN and £N may be calculated as and ~,N = P .Now for each that for a = 0, E*D~N~E*' ~ a~{I,2} T ~N(a) = r calculate and for 0, al ID . 49 = -66 ~N(a) and a = {I,2}, remembering 0* ~N(a) v ~ IN(a) = IN· The fol1mving tables contain the necessary components for calculation. - . e - a - a ~N(a) T' I' ~N(~ ~ 0 ~N(aal o ~N (aa) o o -- ~-1 o -~N(aa) ~N(aa) ~N(aa) ~ O} {2} 33/11 23/11 49 (2) 66 ~(1) 66 49 66 (1) ~(2) 66 66 49 (2) {2} O} 23/11 33/11 4~(2) 66 49 66 (1) ~(1) 49 (2) 66 . 66 49(2) a T ~N(a) = ~ ~ T - D ~N(a) ~-1 - 0 ~ -- T - ~N(aa)~N(aa)~N(a) 0* 66 ~N(a) =0 ~N(aa) -D - 0 -- D ~N(aa)~N(aa)~N(aa) 0 0 {I} 43/22 147/132 {2} 13/22 147/132 {1,2} [33/11~ 23/UJ 49 [ 2 1J 66 1 2 The UI-LMP rank test statistic is T* = N I {cIN(a)£~(~)tN(a))IcIN(a) 2 Q)I(Q~(i)IN(a) ~ o} 0~a~P : U~i, in ;;[-i -~J [~;jinJ = 6.3748 . 28 Note that applying Chacko's test to these data yields the same results, -2 Xrank i.e. = 6.3748. T* To evaluate the significance of P{T~ ~ xiHO} lim N-roo = N use the expression r(a)p{x~(a) ~ x} I 09~P where The rea) may be calculated as follows. For P = {1,2}, r(0) is the probability that both variates from a bivariate normal distribution are negative. Gupta (1963) gives the expression for calculating this probability as f(x,y;p)dxdy where 1 1 + 4 2n arc sin = - ~ Therefore, r({1,2}) r (0) 1 1 = -4 + ~ as p = arc sin (!z) = 2n 1.. 4 1(49/66)(2)(49/66)(2) + _1 (~) 2n 6 = 1/3. Now is the probability that both variates from a bivariate normal distribution are positive, and by sYmmetry r({I}) This correla(49/66) 0) is the correlation between the two variates. p tion may be derived from the matrix = 1:2. p r({1,2}) = r(~). Finally, is the probability that of two bivariate normal random vari- abIes the first is positive and the second is negative. This proba- bility equals the probability of a univariate standard normal random variable being positive minus and by sywnetry 1 - ~ (1) + r({l,2}), r({l}) = r({2}). ~ (.988425) i.e. r({l}) = !z-r({l,2}), Hence, the p-value is +~(. 988425) +}(. 958721)J = . 018 . 29 2.4 T* Asymptotic Nonnull Distribution of N In order to investigate asymptotic power and efficiency properties of T* N in (2.2.14), its nonnull distribution must be determined. {H } N To do this, first consider a sequence of alternative hypotheses where (1) Under the assumptions needed to construct the tests of section 2.2 (see Sen (1981) assumptions (I)-(V)), Chinchilliand Sen (1981a) have shown the sequence of probability measures under that under {H } N to be contiguous to H ' O A thorough discussion of continguity is contained in Chapter VI of H~jek and Sid~k (1967). Let {P } and N {QN} be two sequences of absolutely continuous probability measures on measure space Then the sequence of measures {QN} if for any sequence of events ~(c ~), (~'~'~N)' is said to be contiguous to {P } N (2) Chinchilli and Sen (1981a) use this contiguity to establish the limiting distribution of IN under {H lim N-ID~N = } N as (3) where and N"tOO D both exist and are of full ~ 30 rank. Given the asymptotic of nOl~ality under the in (2.2.14) is now determined. distribution of the statistic The problem is to find T Note that under may be expressed as ~N(a) T ~N(a) (5) ~lfhere mea) (6) and c ~a and c- are matrices such that ~a (7) Thus c T ~a~N N -kzv l' ~N(a) = T~N(a)' .s:.a-IN ._.- and = .-IN(a-) . have asymptotically normal distri- butions, and if their covariance is a null vector they are asymptotically independent. To show this note that Cov(T ~N(a) -0 - 0 -1 -- l' - T - ~N(aa)~N(aa)~N(a)'~N(a) , -1 Cov(IN(a) ,IN (a) ) - Cov(QN(aa)!2N(aa)IN(a) ,IN(a)) o _ .. ~N(aa) 0 - 0 -1 -- 0 -- ~N(ua)~N(aa)~N(aa) =0 Now, ignoring the summation sign, (4) may be written as 31 (9) P{I(QN(~)IN(a)~Q)}p{(r~(a)Q~(~)fN(a))I(IN(a)~Q»~} = p{ ICQN (~) IN (a) ~Q) }p{ I cIN(a) ~~) }p{ cI~ (a)QN(~)IN (a/xl IN (a) ~Q} = r*(a)p{(r~(a)QN(~)rN(a))>xIIN(a)~Q} where (10) It is now desired to show that the expression in (9) is equal to (11) ·e This is accomplished by applying lemma 3.1 of Bartholomew (1961). First note that there exists a matrix D* (12) ~N(a) C such that ~ =~ CC I Then (13) Let (14 ) and express D*-l ¥ v TI (15 ) Since i" ~N(a)~N(a)~N(a) ~N(a) V T ~N is normal, and (C I) ~ as -1 C -IVT ~ ~N(a) = ZIZ ~ ~ 32 Var (z) (16) = ~k(a) I the elements of z = ( z1 ' ... , zk ( a) ) variables with means lJ-:' 1 i are independent normal random say, and unit variance. Now make a transformation to the polar coordinates (r,8 , . .. , 1 Let (17) Z. = r cos 8 - ... cos 8k ( ) . 2 sin a 1 1 defining sin cos 8 0 -1- :: 1. 8 kCa )-i-l ' i=l, ... ,k(a) Now becomes (18) P{r Since r 2 2 > x Irestrictions depending on is independent of 8 "" ,8 (a) -1 1 k 8 " .. ,8 (a)_1' 1 k only} . the restrictions on the angles can be ignored which implies that the probability in (9) is independent of the restriction INCa) ~ 0, and may be expressed as (11). Furthermore, since (19) the asymptotic nonnull distribution of lim P{T* . N~x} = (20) N+= where 2 X [k(a),~(a)] (21) r*(a)P{X 2 can be written as [k(a),~(a)]~x} is a random variable having the noncentral chi- squared distribution with parameter I Q'cacP T*N k(a) degrees of freedom, and noncentrality e· 33 The method used to calculate the section 2.2 that the rea) r*(a) follows. Recall from are the products of certain normal orthant probabilities for the null mean case and sum to For the nonnull 1. case the mean is shifted from the origin, and some adjustment must be made. For a given set a, define R(a) to be +1 or -1 times the probability of the subspace or region corresponding to the shift of the mean from the origin, the sign depending on the direction of the shift. Then (22) r* (a) ::: r (a) + R(a) where rea) also sum to ·e to the r*(a) is calculated as in the null case. 1 Note that the I R(a) ::: O. More weight is given a associated with a positive shift in the mean. which implies that For illustrative purposes consider calculating p ::: 2. Assume that to calculate (23) IN r*({1,2}) note that r*({},2}) ::: P{T >O} ~N ~ """"N -jJ (24) > -jJ} rooJ ("'oJ ::: r({l,2}) r*({l}) r*(a) is distributed normally with mean p{ (T To calculate r*(a) + R({l,2}) . use the relation r*({l}) ::: P{T ::: P{T NI N1 > 0, T N2 > O} - r*({l,2}) > O} when ~. Then 34 where the marginal distribution of calculation of r*({1,2}). r*({2}) T NI is univariate nonnal. is similar, and 1'*(0) = The l-r*({l}) - r*({2}) Numerical methods or approximation fonnulas may be needed to calculate these probabilities. Some comments may now be made regarding the asymptotic power and efficiency of the UI-LMP rank test. value x, For a given a-level critical the asymptotic power function may be expressed as a (25) In general, both the asymptotic power and efficiency are functions of all possible ~(a)'s where a is an element of Here the power function depends on ~(a) 2P possible sets. in a very complicated way, and Pitman efficiency is not generally applicable. Hence, a numerical study is needed to further investigate the asymptotic power and efficiency of this class of tests, and this will be dealt with in Chapter 4. This study will compare the UI-LMP rank test to other tests for both the cases of equally and unequally spaced ordered alternatives. Tests such as Jonckheere'Stest attain their maximum power under equal spacing. The UI-LMP rank test is valid for any spacing of the alter- native, and its power is expected to be greater than that of either tests when there is unequal spacing of means under the alternative. 2.5 Local Asymptotic Power and Efficiency When the mean under the alternative is very close to the origin, local asymptotic power and efficiency may be investigated. Writing the e· 35 o~ alternative as (1) where 13(0:) = I ~ is fixed, the power function 2 r*(a)p{x [k(a),L'l(a)] a can be expressed as a function of ~Xo:l{HN}} and examined as 0, 0 Compar- O. + ing the slope of this power function \vith a slope from another test produces a measure of local efficiency. This method will now be described in general terms, followed by an example for the bivariate case. As in section 2.4, express r* (a) = r (a) (2) where ·e r*(a) R(a) parameter as + R(a) is now expanded as a function of L'l(a) O. The noncentrality can also be written as a function of 0, namely (3) where );!,(a) = EcIN(a) I{H }). N Now for a given set a, the noncentral chi-squared random variable in (1) can be expressed as an average over central chi-squared random variables having different Poisson weights and expanded to a power series in o. The product of the two components in (1) is also a power series in O. Summing depending on L'l(a), over all possible a, the slope of the power function at the origin can be calculated and compared to that of another test to yield a measure of local efficiency. Consider the following bivariate example. distributed normally with mean first step is to calculate o~ R({1,2}) Assuming that and finite variance so that r*({1,2}) QN' = IN is the r({1,2}) + 36 R({1,2}) may be obtained. Making the transformation (4 ) where is a diagonal matrix such that d don matrix of IN' the probability dOd' ::: p ~~~ r*({1,2}) is the correla- is written as (5) Now z is distributed nonnally with mean r*({I,2}) is equal to of the shaded r({l,2}) 0 and variance £, and plus the bivariate normal probability region below. I I I I I : (hI' h 2 ) I J---------------- (6) ::: r({I,2}) + R({l,2}) . e· 37 R({1,2}), To calculate the bivariate normal density is first expressed as the product of marginal and conditional densities, and the area of one strip is calculated, R({1,2}) other strip, and Then the same is done for the is the sum of the probabilities of the two strips plus the probability of the rectangle defined by the coordinates, h ,h , l 2 and the origin. ! The bivariate normal density of is written as follows: (7) g (2 1 , Z ) 2 1 =: C2 2n l-p 1 12-;~ =: ·e where ~(zl) cx{ ~J -Z exp "'l (Z2 _ 2 Z 2 + Z2) 2 1 1 2 2 2 (l-p ) I 1 1 J -f I 2n(l-p 2 ) ex{ 1 ~ 2 (l-p 2)J (2 _ 2 Z )2 1 is the standard normal density function, and is the conditional density of strip along the axis is (8) Making the transformation, (9) (8) is now written as 2 2 given zl' g(z2 1zl) The probability of the 38 _ z2 1/2 e --- _ rh.1 - J where ¢(zl) a e-Z~/2I[ PZ1]~ I¢ --lldZ I2TI L ~_p2~ I is the standard normal distribution function. P zl Taylor's theorem to expand ¢l( - ] around the point a Using yields Q e· (10) If:~(hl) 2 ~ - ¢(O)J + l n; 1 1 p where the fact that t zl¢(zl)dz a expanding ¢(h ) l E_ 2 l ~ ~(O) = ¢(a) - ¢(b) in a Taylor series around order terms involving hI (since of the first strip is written as hI + o(h~) is used. 0, Finally, and ignoring higher is very small), the probability j ~-ili 1 (11 ) ~ - ¢(hl)J 2 _h e 1/2 39 = I <P 1 2 (0)2 { hI - 2 hI 2.- l} r 2 /2; l-p Similarly, the probability of the strip along the zl-axis is calcu- lated as (12) and that of the rectangle as (13 ) for hI and -e h 2 =b where o a1 a = {1,2}, and both small. 0 + b and b 0 al R({1,2}) is written as 2 are the above coefficients of 2 0 , respectively. 1 After calculating (IS) a2 Thus r*({1,2}), r*({l}) can be expressed as 40 A Taylor series expansion of ~(oTl) around 0 yields (16) and (15) can be written as where higher order tenns involving 0 are ignored. r*({2}) is similar, and the respective R(a) The expression for may be obtained by sub- traction using the relation R(a) = r*(a) - rea) . (18) As in (14) denote R(a) (19) R(a) where the a. as b 's are the coefficients of the 0 terms for a given set a Note that while r*(0) may be obtained by subtraction, it is not a factor as To express the power function in (1) as a function of consider writing as 6 (20) P{/[k(a),6(a)] 2:x } = e- (a) a e -6 (a) 0, r~ {2 >} ~ Xk(a) - x a 00 I (6(a)) r! r=O { 2 r P{ 2 >} Xk (a)+2r- x a >} + 6(a)P Xk (a)+2 - x a J 1 6 2 (a)P{X 2 (a)+42: x } + ... + "2 k a first 41 1 3 2 - ;[ 1'1 (a)P{xk(a)+42: \x} + •.. ~ = P{ X ( a) 2: Xa} + 0 2 (~ ~' (a) Q~ ( ~ ) ~ (a) J (P { X~ (a) +2 2: -P{X~(a) where = 21 c aO Now, using (2), ~ '( )0*-1 (' a ~N(a)~ aj, Xa } 4 2: x }) + 0(0 ) a and (14), and (20), (1) is written as (21) Sea) = Ir*(a)P{/[k(a),l'1(a)] 2: x } a a = I(r(a)p{X~(n) 2: \.x}) + 82Ir(a)caOCa1 + a 2\ a 2 + 8 L b a 2 p { Xk (a) 2: a a,oLbalP{X~(a) > \} a X a} + oIba/{X~(a) a a} 3 0 ( 0 ) + ozGr(a)CaoC al + ~ 2:X Lba2P(X~(a»x";lJ a 3 + 0(0 ). 42 Having expressed the power function as a function of 6 when 6 0, -+ a measure of local asymptotic efficiency may be obtained by comparing the slope at the origin of the above function to that of a competing test. This slope is dS(a~) (22) do where b al I 0=0 is the coefficient of 0 In the expansion of R(a). Consider Jonckheere's test, and the normal scores test as two competitors of the UI-LMP rank test. Let the alternative be defined as in (2.4.1), and assume that each of the number of observations n such that of Puri (1965), and letting V N k N = nk. = N- 3/ 2v, samples has the same Following theorem 5.2 the appropriate limiting distributions may be written as (23) and (24) where J, and NS stand for Jonckheere's test statistic, and the nor- mal scores test statistic, respectively. The asymptotic power of these tests is generally written as (25) where l a is the upper 100a percentage point of For the case of loca 1 al ternatives write This amounts to writing A. 1 as ~(x). )1* = 0 (y*) where 0 -+ O. 43 (26) ), 0 ::: 1 oy 1 0 for , i::: 1, ... ,k . Expanding (25) in a Taylor series around T a yields 2 S(V )::: <P(T )+<jJ(T )[Y: 0-2T )+0(0 ) , N a a 0 a (27) and taking the deri vati ve of this power function at the point gives (28) Now for Jonckheere's test flj (29) and (28) --* ::: oj 1S { I 18 } 2 (Y.-Yo) 0 , lIT(k -1) i<j J 1 expressed as (30) For the normal scores test {+- (31) I o. (Yo-Yo)}o, J 1 k - 1 l<J and (28) is written as (32) mNS ::: ep(T a Finally, writing (22) as (33) ){+ k -1 I i<j (y,-y,)}. J 1 0::: 0 44 the local asymptotic efficiency of the to Jonckheere's test 1S m* -y, rank test with respect and with respect to the normal scores m test its asymptotic local efficiency is 2.6 UI-LMP m*/~S. An Application to Mental Health Data Consider the following hypothetical example which was suggested by Turnbull (1982) regarding an ongoing study of depressed inpatients. The study objective was to test the efficacy of isocarboxazid, an antidepressant also known as Marplan. The impetus for this hypothetical example was an extension of the work of Davidson et al. (1981). Suppose a double blind clinical trial was conducted and 38 patients were observed for a period of up to 6 weeks. During this period 12 patients received a placebo, 13 patients received 30 mg of Marplan, and 13 patients received 50 mg of Marplan. Each patient was assessed for depression at baseline, and at the end of the fourth week using the first 17 items of the Hamilton Depression Scale (see Hamilton (1967)). The observation on each patient was the sum of the Hamilton scores at week a minus the sum of that patient's scores at week 4. This obser- vation is termed the change score, and theoretically could range from -52 to 52. Suppose the investigator is interested in testing for an ordering of the three treatment groups. A priori one could hypothesize that at the end of the 4 weeks, the patients receiving 50 mg of Marplan would have greater change scores than the 30 mg group, which in turn would have greater change scores than the placebo group. observations appear below. The rants of the 45 Treatment Ranks Placebo • 8 14 2 7 23 3 1 5 13 17 11 12 Marplan (30 mg) 32 16 15 10 26 25 30 27 28 Marp1an (50 mg) 38 24 22 20 34 33 37 35 36 19 29 31 6 9 18 21 4 Using the same model as in section 2.3, define £1 = = £12 = £13 = ... =: £25 = £26 = ... = £38 = (0,0) , (l, 0) , (0,1) , , data are not derived from a continuous distribution, because the observations are obtained by summing the scores of the first 17 questions the data may be asymptotically normally distributed. tational simplicity logistic scores of the form are used. aNCi) For compu- +\- 1 = 2i;939 = N2 These scores coorespond to the locally optimal choice of scores when the underlying distribution is logistic. A very similar case holds for the normal scores. The vector T ~N is calculated as (T 25 T = NI I ,T and 38 I i=26 To calculate the variance of aN CR.) IN' I 1 N2 15/39 , aNCR i ) i=13 N1 = 221 39 calculate ), where 46 N I C ~N (£i-SN)(£i-SN), i=l 1 1963 L:481 = 1444 -48n 963J' and • Then .-PN 2 = AN~·N .- 1 1963 4446 L:48l = To test against the ordered alternative, -48ll 96~ . and IN QN are transformed to = IN 8( [1 L9 1 15/39J 221/39 = (236/39) , 221/39 and ,~ QN = II [1 L9 respectively. G TI1 e- 1 ~64 = 4446 482 48TI 963 ' The components needed to calculate the UI-LMP 1 r963 Ij 4446 L:481 -48Il 96~ 1 statistic are given below. a - a ~ ~ T' Tf - ~ o ~N(aa) 0 o ~N(aa) ~ o -~N(aa) ~J-l o -- -- ~N (a). {l} {2} 236/39 221/39 964/4446 482/4446 482/4446 963/4446 4446/963 {2} - ~N(aa) -- v ~ ~ ~-1 ~ T = T -0 - 0 -- T "N (a) "N (a) ""1\J (aa) ~ (aa) ~ (a) ~ a {2} ,2} ~N(aa) {l} 221/39 236/39 963/4446 482/4446 482/4446 964/4446 4446/964 a {l} {l ~N(a) 0* ~(a) t"'V !"oJ ::: 0 -0 - ~(aa) ~N(aa)~N(aa)~N(aa) 3.22 .163 2.64 .164 (236 221)' l39 ' 39 f'oI-I "" - 0 -- 0 1 4446 ~64 482 48TI 963 47 The UI-LMP rank statistic is . r 221) 117 963 39 18316 l-482 [236/39)~ -4821 96~ 221/39 ~ ::: 211.83 , and the asymptotic p-va1ue is O. Remembering that this is a ficti- tious example, the investigator's hypothesis is overwhelmingly supported. An Example Involving Two Factors 2.7 Tests against ordered alternatives in randomized blocks with more -e than one observation per cell have been considered by Hettmansperger (1975), and Skillings and Wolfe (1977, 1978). for X.1)'k i Consider the model = 1, ... , p j=l, ... ,q, and where B. k = 1 , ... ,n .. 1J is the random effect of one factor, . th the J treatment, and J CI,).) th cell. Let is the number of observations in the n .. I) n. ) = is the effect of T. 1 q P I i=l it may be reasonable to assume n .. , 1J that and B. 1 I N = = is no point in testing for order among the n .. j =1 a ) for all B. 1 In many cases i, and there if the investigator is only concerned with the ordering of the treatment effects. For this situation, the results of Chapter 2 may be applied directly. An example is now presented using a set of hypothetical cat data. Nine fictitious cats, all new mothers of the same breed, were selected 48 for the study. Their litter sizes vary. Three different types of ration were randomly allocated to three treatment groups. consist of three randomly assigned Ii tters each. there is no mother effect, i.e., no litter effect. These groups It is assumed that The weights of the kittens were recorded when they reached the age of 3 months. The investigator hypothesized before the study that the kittens who were fed ration 3 would be the heaviest, and that ration 2 kittens would be heavier than ration 1 kittens. As it happened, the hirthweights of all kittens were virtually identical. The data appear below. !2ypothetical Cat Cat Treatment 1 Treatment 2 Treatment 3 l- ~ Data Kitten weight in grams at 3 months 822 737 741 935 938 1128 547 3 958 598 1601 4 5 6 867 1033 1404 666 731 714 921 979 1417 533 595 897 7 8 9 1088 1360 1312 765 870 1091 962 1298 377 802 877 e 836 1407 Ignoring the cat subscript, define the model for (2) where T. J is the effect of the J·th ration, £1 = = £11 = (0,0) , £12 = £24 = (1,0)' £25 = = £35 = (0,1) , tl j .Q,=l, ... ,N 1 = 'j-T 1 , and - 49 To test ~21 H : O - ~31 = tions are ranked from 1 0 against to N, Ha : 0 ~ ~21 ~ ~31 the observa- and the logistic scores £-18 18 (3) are used to calculate the LMP rank statistics. Cat Treatment 1 Ranks of kitten weights at 3 months 3 22 5 35 9 10 20 21 28 4 5 6 15 25 32 6 8 7 19 24 34 4 18 7 8 9 26 31 30 11 27 1 12 16 17 23 29 1 2 Treatment 2 Treatment 3 ·e To calculate the vector IN' 13 = I £=] 3 14 2 33 first calculate 35 T NI The ranks appear below. 24 c n aN (R.Q,) = I 9.,=]2 aN(R£) 7 =- 8 , and 35 I T N2 £=1 35 I c9,2 a N(R9,) £=25 25 aN(R£) = 18 To calculate the variance of IN = [- 18 , 7 25) 18 note that N fN = 1 r286 (£9,-SN)(££-SN)' = 35 L:143 £=1 I -14~ , 264 50 and 35 108 Then 1 r 286 108 L:143 -1431 26tU . The transformation matrix needed to construct the test against ordered alternatives is and the transformed vector, and its variance are e· and P .-N respectively. = E*D E*-l = ~ ~N~ 1 ~64 108 U2l 12n 264J The components needed for the calculation of the UI-LMP statistic are given below. a a {l} {2} {2} {l} II ~N(a) 25 18 Ti_ ~N(a) o ~ D - o - ~-1 o -- D (aa) -- ~N(aa) 121/108 264/108 108/264 121/108 264/108 108/264 ~N(aa) ~N(aa) ~N(aa) 25 18 264/108 121/108 1 264/108 121/108 ~N 51 v T a ~ ~N(a) ~ =T ~N(a) ~~1 -0 ~ - D -- T ,. . ." D* - ~N(a) ~N(aa)~N(aa)~N(a) "'" =D ""-1 -D ~N(aa) 91 o {I} 157/432 5005/2592 {2} 67/72 5005/2592 {I, 2} [1 , [264 1 25) , 18 "" - D -- D - ~N(aa)~N(aa)~N(aa) 108 1211 264j U2l The VI-LMP rank statistic is I fl et'· D*-l 1 )I (1 ~N(a)~N(a)~N(a) ~N(a) T* N a r. = II(~ 1 , 25) 108 > - I 0) (D*-! ~ T - ~N(a)~N(a) < - O)} ~ 1 24 18 5005 l-ll ::: 0.8575 . ·e To evaluate the significance of T* N = I use the expression r (a) a where r(0) = r({l,2}) = = p-value 21 - .326 ::: .174. 1- [.326(1) + J+ 21 Tf arc sin p{ ~ X ( a) s x} l21'J = .326, [ 264 and reO}) = Then the p-values is calculated as .174(.645561) + .174(.645561) + .326(.348677)] .336 which does not support the investigator's hypothesis. 2.8 Testing for Order in an Analysis of Covariance To construct vr -LMP rank tests against ordered alternatives in the analysis of covariance, one must consider the conditional 52 distribution of the principal variate given the covariates. While this is a difficult problem, DI rank tests can be constructed quite easily by combining the method in section 5.9 of Puri and Sen (1971) with the procedure already described in this chapter. The basic problem is that all permutations of the rankings are not equally likely under the covariance model. There is a need to eliminate or adjust for the effect of the covariates. Following Puri where and Sen (1971), consider a stochastic vector Xl is the primary variate, and stochastic vector. ~ = (X , ... ,X ) 2 p is a concomitant Interest lies in testing for order among the locations of the first variate while utilizing the information contained in the covariates. Let N be the number of observation vec- tors, and define the matrix of ranks as (1) ~ (R (1) R(l) 11 ln R(1) pI R (1) (c)l ln c R l = pn l R(c) J pn c th is the number of observations in the k treatment group, c k = 1, ... ,c, and I n k = N. Each row of ~ is a permutation of k=l 1, ... ,N, i. e. for each variate, the observations are ranked from I where to n N. k Define the rank statistics I (2) where nk c ak is Further define N I a=l o (l) c kaN(R. ) a la or as k=l,'H,c, i=l, ... ,p is calculated as in (2.2.4). 1, where V(E~) 1 c - I N k=l 53 To utilize the information contained in the covariates, Puri and Sen (1971) suggest fitting a linear regression of T~~). on (k) T N2 " ' " The adjusted test statistics are defined as (4) k=l, ... ,c where is the cofactor of V.. 1J T* Nq and for v .. (!t*) 1J ;;.,,~ k, q=l, .. .',c in V(B:-*). ""N The covariance is defined as (5 ) okq where is the Kronecker delta, and Denote this covariance by d kq , Ivl and let the covariance matrix of the test statistics. -e statistics T* - (T*Nl"'" T*)' ~N Nc ' been defined, the Since IN (T = inverse of tistics 2.9 (T N1 , ... ,T D* ~(3) Nl VI statistic Nc )' is the determinant of D = ((d q )) k be ~ Now that the vector of and its covariance matrix D have may be calculated as in section 2.2. is of rank c-l, either the generalized must be used, or alternatively the vector of sta- ,··· ,T _ ) Nc l may be calculated as in example 2.3. Example A swine research unit was interested in comparing three different feeds. Thirty young pigs were randomly assigned to three groups of size ten each, and fed the appropriate feed for an equal number of days. The researchers were interested in finding out if feed 1 resulted in lower weight gain than feed 2, and if feed 3 resulted in the largest weight gain (Xl)' ~ain. In addition to the primary variate, weight the researchers wished to include the covariates age S4 (X ), 2 and birthweight in the study. (X ) 3 The matrix of ranks appears below. Xl X 2 X 3 26 12 1 14 16 30 20 9 28 26 14 3 2 27 28 26 13 24 6 16 9 15 2 13 4 10 20 11 5 6 27 19 29 3 22 EN 17 23 18 9 24 22 30 23 25 11 17 16 24 15 11 8 20 7 12 8 3 4 18 30 28 21 15 25 27 21 19 29 10 14 8 29 19 13 21 23 2S 7 12 1 5 22 17 18 10 5 1 2 4 7 6 As in previous examp 1 C'~;, let and define 1\1 tested against :=: 8 Ha : k - 8 for 1 o:s: lI 2l :s: lI two covariates. To calculate as k 31 Feed 1 8 :=: Feed 2 e· Feed 3 be the effect of k k 2,3. Then HO = lin :=: th lI 31 treatment, :=: 0 is whi 1 e adjust ing for the effect of the (k) T ' k Ni :=: 1,2, i :=: 1,2,3, first define 55 .. = £1 = = and use the logistic scores = £30 aN (cd T(k) Ni Then using (2.8.2) the (0,0) , = £20 = (l, 0) , £11 £21 = £10 (0,1)' 2a 2a-31 -1 = N+l 31 = are calculated as 19 , T (2) N1 T(l) = -12 , N2 155 T(2) -12 = 155 , ~(2) T(l) N1 Tel) N3 155 cev .. (R *))) 1J ~ N a=1, ... ,30. N2 lN3 = 24 , 155 9 = 155 , = 1 155 is cal culated using (2.8.3), and its value is ·e r 1 14415 The cofactors of v 1J .. (RN~) ~l· 4495 -289 1269 for V ll -289 4495 2991 l269~ 2991 4495 i = 1,2,3, = . J' = 1 are .054 V21 - .025 V31 =-.032 and the determinant of V(B~) Ivi IS = .014 . Finally, using (2.8.4) and (2.8.5)' the vector are calculated as T* = (.133 , ~N .178)' , IN' and its variance 56 and -. 0091 0= r'.018 ~ 009 L:-. .011U Now the UI statistic is calculated just as in previous examples. Remember that the vector (.331, .178) IN must be transformed to which has variance I, test the ordered alternative. Ul test statistic is N* = T 0 = Q*Q£*' = T* = ~ E*T* = ~N ~N [018 .009 ,00TI .018 ' to Applying (2.2.14), and (2.2.16), the 5.41, and the asymptotic p-value is .029. 2.10 Testing for Order in a 2 Factor Experiment In a 2 factor experiment, an investigator may wish to test for order among the levels of both factors. 2 factors easily. is assumed null, such tests can be constructed quite Consider the following model. (1) X" IJ k , IS where factor If the interaction between the 1 = ]J+S.1 +T.J Let +E" IJ'k ~ k th 0b ' ' th 1 eve 1 of tIle servat10n correspon d'1ng to th el and the jth level of factor j = 1, ... ,p, k = 1, . .. ,n. Is. E'S . 1 are 1J 1 J To construct tests = 1 n i = 1, ... ,m, observations in each IT.J . = 0, are in effect. J i.i.d. continuous distribution function F(x. 'k), f(x, 'k)' and There are exactly cell, and the usual side conditions, It is assumed that the 2, random variables with and continuous p.d.f against ordered alternatives, first note that an overall ranking of the observations is inappropriate since the rankings are interchangeable only when both main effects are equal to zero. Therefore, a transformation must be made to eliminate the e- 57 effects of one of the factors from the model. Then the ordering of the effects of the remaining factor may be tested. Following the technique introduced by Crouse (1968), the transformed variables ill (2) Y' k .I = L X. 'k 1.1 i=1 can be regarded as tion with c.d.f. the sum of the B.1 p for k = 1, ... ,n , random and independent samples from a populawhere m i.i.d. j = 1 , ... ,p, G is the distribution function of random variables each with F. c.d.f. Now effects have been eliminated from the model, and the problem reduces to one of testing against ordered alternatives in the one-way layout. ·e The results of section 2.2 may be used for this problem, and the optimal scores are now calculated LMP using the c.d.f. G(Yjk). The rank test against the hypothesis of an ordering of the S. IS 1 is constructed in the same way. If the E" I) k have mean zero and finite variance . no matter if normal i ty holds or not, the sum IE,I)'k i will be approximately normal if the number of elements is not too small. For this reason, a non- parametric procedure which is good for nearly normal distributions is appealing. 2.11 Summary In summary, Sen (1981) has proposed a method of test construction for multi-parameter problems which results in certain optimality properties. This method uses the UI principl e to extend the Htij ek- Sidtik LMP property from the two-sample case to the multi-parameter 58 case. Applying this theory to the multiple regression model, the test against ordered alternatives has been derived as a special case. The results of this test correspond to the test of Chacko which implies that Chacko's test is optimal when the underlying distribution of the data is the logistic distribution. The nonnulldistribution of the VI statistic has been established in order that asymptotic power and efficiency might be investigated. In general, expressions for power and efficiency are very complicated, but for the case of local alternatives such expressions may be obtained, and this has been discussed. Finally, an application to mental health data, a simple extension to the two factor case when the effects of one factor can be ignored, a test for the analysis of covariance problem, and a brief discussion on testing for order in a two factor experiment have been presented. The next chapter will be concerned with extending this theory to the analysis of randomized blocks. e· CHAPTER 3 Optimal Rank Tests for Ordered Alternatives in a Complete Blocks Design 3.1 Introduction Now consider the problem of extending the VI-LMP rank test method to tests against ordered alternatives in block designs. methods will be examined. within block rankings. The first method concerns tests which use The second and third methods concern tests which use aligned and weighted rankings, respectively. three methods will yield a different result. depends on the method used. Each of these The optimality property In general terms, each method will involve applying the Hajek-~idak theory to a different type of density. for each result, the Three Then principle is applied to construct three dif- VI ferent types of tests. Also, comments are made regarding the analysis of covariance, and the 2 plete blocks. 3.2 factor experiment replicated in n com- The within block rankings case is considered first. Within Block Rankings X.. , i == 1 , ... ,n, j := 1, ... ,k be a random vari ab I e corre1J .th } '1 th a f · span d 1ng to t1e n blocks and the J of k treatments Let in a complete blocks design. The X.. 1J independent with distribution functions for the F.(X-8.) 1 f (x-8 ). i j i J th block are assumed and continuous pdf's Alternatively, following the notation of Chapter 2, the pdf 60 X.. for the random variable may be defined as IJ f .. (x) :: f .. (x-a-c!lI) (1) 1J where c. and -J II IJ -J- are defined as before. Blocks are assumed indepen- dent, and block effects are assumed additive. HO: again of the form ;:., :: The null hypothesis is O. Within each block the observations are ranked from Let Then the R.. 1] R. x n .th observation in the J .th is the k-vector of ranks for the -1 k .th be the rank of the 1 1 to k. block . 1 block, and R is Before deriving the matrix of within block rankings. locally optimal scores, the following assumptions are made. Assume that for every 1 where the sets (2) Then f·e(x;S) -1 - f~ IX f~ IX IX For almost all x (4) f~ - - X E I, 1 - 1 yf r - the limit lI~O 1 - - j XE r rXJlf~IX (x;lIy) Idx - =: foo If:< IX _00 (x; 0) Idx - Let (3/3l1)f. (x;lIv) (x;O):: lim ;:.,-l{f. (X;lIy)-f(x;O) I exists, and for every _00 =: - (x;lIy) - y'f,s(X;lIy) and IX (X;lIy) -e:: lIy,- and for a.e. f~ lim and '-'0.1 exists 1I~0 - are as previously defined. f Cd/(6)f. (x;6) ...... 1 (3) (5) -y -r rand is absolutely continuous I, f. (X;lIy) < 00 . ~ 61 These assumptions follow those stated in Sen (1981) and allow the theory v of Hajek and Sidak (1967) to be applied to the multi-parameter model. They are general in nature and cover the more specific case defined by the model in (1). ~r, Now, instead of using the vector tive hypothesis is formed using the scalar quantities quantities shall be denoted by the alternac!y~. ~J~ These j=l, ... ,k. ~c., J To derive the optimal statistics, first note that the' probability of observing a given set of within block rankings is n = (6) JR ••• k n.k f IT IT f. (x .. -6 J i=l j=l 1 : fr {J .. .f n j=l R. 1=1 ~1 = fr {f···J{ i=l R. n j=l 1J .)!T TT dx .. i=l j=l J f. (x .. -6.) 1 f. 1 1J ex< J n j=l 1J dx .. } 1J .;.6c.)dx· 1 · .. dX· k} . 1J J 1 1 ~1 Under H' O the probability of observing any set of within block rank- ings is (7) Following the Neyman-Pearson Lemma, form the ratio (8) g (8) / go (8) = (k!) nfr!f· .. J-IT f. ex . .;~c J<) dx. 1 ... dx. k} i=l l R. j 1 1J 1 1 ~1 {rJ." TT . 1 R = (kl) n n 1::: ~i Jr k 1 TTf. (x .. ;OJdX· l <<<dx' k . 1 1J 1 1 J r ;~c .)-ITf. (x. <;o)JdX<l< . (x.1J< frf . 1 J J < J 1 1J 1 0 odX·1 k} 62 = (k!)nfr{k\ + /::, i=l . I J... Jrq..(f. ~ R. j=l 1 (x .. ;/::'c.)-f. (x .. ;0)) IJ J 1 IJ ~1 k L I J···Iq..(£. L4 1 (k!)nfT{k ,1r+/::'k! i=l . j=l ;o~.(x. ;/::'Cn)~dX'l" .dX· } nIl N NIlk n f. (x. · 111m m=J+ x := '-1 R. 1 n 1 N= (x .. ;/::'c.)-f. (x .. ;0)) IJ J 1 IJ ~1 k x nf.(x. · 111m m=J+ n ( n~l+tJk! i==l l I . -1 ;O)n£.(X.n;/::'Cn)~dX·l···dX·k} nIl IN NIl N= I ."JrG1-(f.(x .. ;tJc.)-f.(x .. ;0)) k j=1 R. 1 Ll IJ J 1 IJ ~1 k rTf.(x. · 111m m=J+ x l+~k! i I== 1 I I···I~-(f.(X . = 1 R. ~l J L:. 1 . -1 ;O)nf.(X.n;/::'Cn)~dX·l· .. dX·k} nIl IN NIl N= .. ;6C.)-f.(X .. ;0)) ] 1 1J 1J k x TI · m=J+ + '-1 f.(x. ;0)nf.(X.n;6Cn)QdX·1···dX·k 111m n 1 1 IN NIl 0(6) N= when 6 is sufficiently small . Following the proof of Theorem 4.8 of Hajek and ~idak (1967, pp. 71-73) which applies here with minimal differences, it can be shown that I f···fL~·i. n = 1+6k! I J . 1 i=l P' R. 1 (x 1..J ;O)nf. (x.1m ..J.' 1 m, J ;O)~:lTrdX" J J . 1 ~l n := 1-6k! I c·f···J I i=l j=l J n = 1-6 I R. ~1 tI } f.(x .. ;O) k ~k / ( 1J 0) (x. ;0) ITdx .. . x..; 111m . 1J 1 IJ m= J .. ;0) L c.E {-f.1 (x IJ k i=l j=l J R. fi(xij;O) ~1 TI£. 63 = 1-~ k n L L c.E '=1 . J= 1 where z.. is the 1J jth 1) {-f. (z .. ,O)} . 1 1) 1 1J f.(z .. ;0) order statistic of a random variable having f.. Then for a given the pdf the LMP intrablock rank statistic 1 is given by k n I (0) I c.E {-f. i~l j=l J where c. 1J fk(zij;O) i s give n by J Let (z .. ;O)} 1 c ! y, j::: 1 , . . . , k . . ~J~ -f.(Z .. (0) _ E 1 1J . 1 k J J = , •.• , , { f.(z .. ;0)" i ;O)} o 3 1 denote the optimal scores. 1J Then (10) may be rewritten as n (11) TW(Y) ~ The scores a.(j) = k I I c.a. (R .. ) i=l j=l J 1 1J may be calculated as 1 . _ [k-1) foo f.(x)[F.(x)] . j -1 [l-F.(x)J k -j dx, (12)a.(J)- .. k ' 1 J- 1 1 1 . 1 _00 i=l, ... ,n; j=l, ... ,k, and are the same scores as in Chapter 2 except that these are calculated from samples of size The a. (j) 1 k rather than nk. are also the same as the optimal scores givin in Puri and Sen (1971, p. 271). integrated by parts. For To see this, the above score function is i = 1, ... ,n and j = l, ... ,k 64 a.(j) 1 = E{ -f.(Z .. ;O)} 1 1J f.(z .. ;O) 1 1J k-IJJoofi(Z) f. (z) = -k ( j-l = _00 . k-j [1\ (z)] j-l [l-F f i (z)dz i (z)] 1 -k(~-llJfOOrF. (z)]j-I[I_F. (z)]k-jdf. (z) lJ1 1 1 (00 - J f.(z)[F.(z)] 1 1 j _I (k-j)[l-F.(z)] 1 k _ j -1 I f.(z)dd 1} +k(k-l) [ k-2Jfoo j-2 f 21 (z) [F i (z) ]j-2 [l-FCz)] k-j dz which is the form of the optimal score function obtained in Chapter 7 of Puri and Sen (1971). The advantage in using this form is that the scores may be easier to calculate. Also note that if the assumption of constant error variance is a (j) = a(j) i is assumed, made, the scores are the same for each block, i.e. for every i. If a the scores may be derived heteroscedastic using the model model 65 I fC-SiJ f. (x) -- -O. 1 where O. 1 1 1 .th common variance of the 1 a (j) f. .th is the S. block. 2 o. block effect, and 1 Then the score 1 is a. (j) :: :. a (j) , and 1 1 is the same with 1 replaced by (10) becomes a weighted average. f. If the If the o. 1 o. 's are known, '5 are unknown they may ] be estimated using the block range or some other estimate of the block variance. Some function of this estimate may be used, e.g. the rank of the range. More attention will be paid to this point in the sec- tion on weighted rankings. The are introduced only if it is O. '5 1 believed that they differ among blocks. Recall that the statistic I w:: where ::: Wm where p ing the model. I I i=1 j:::l is defined as c. a.(R .. ), Jm 1 1J is the dimension of k, m=l, ... ,p and the c. Jm Once the vector of optimal rank statistics, is formed, the Tank test. ylT,v ~ ~I UI principle r Y f f 1 depend- T = (T '" .,T ), , Wl Wp W UI-LMP subj ect to certain restric- "1 r, E{r'~W IHO} = a and is defined as follows. Let . th (2.2.9), only calculated for the i. l Ow-1 ~ block . var{r'~wIHo} = ~y'O~W~y be defined as QN in Then for the hama- are all equal, and °"WI. = ° For the heteroscedastic model where the scores are of the scedastic model the form or 1'. QW for all 0 As in Chapter 2, this involves forming the statistic For every fixed where are is applied to construct the and maximizing it over all tions on y'T~W ~ k n T 011 and (TWl,···,TWp )', (13) in (10) is given by Ok ~ ~i 1 n a. (j) = 0." a (j), Q = ) 1 w 1 1 2" QWi . 1=1 o. 1 66 The results of Chapter 2 may be applied to construct the UI-LMP rank test. A transformation is used to change the problem from one of testing against the ordered alternative to one of testing against an orthant alternative. xiIw The Kuhn-Tucker solution for maximizing r~ subject to the constraints same as in (2.2.14). Q and X'Q,w X :: constant is the The exact small sample distribution may be obtained by considering the (k 1)n possible equally likely within block ranking permutations, whereas the asymptotic distribution of the UI statistic is as in (2.2.16). An example follows. Consider a compl ete blocks design with n:: 7 blocks. k = 3 treatments and The within block rankings appear below. Block Treatment 1 2 3 4 5 6 7 I I 1 1 1 3 I I 2 3 2 2 3 1 2 2 3 2 3 3 2 2 3 3 The model of interest is (1) where F .. ex) :: F.(x-8.) , 1J 1 J 8. J is the effect of the i:::l, ... ,7; j=1,2,3 . th ] treatment. define (2) 6. = 8.-8 1 ' i1 J Now the model may be experessed as j=1,2,3. As in example 2.3, 67 i=1, ... ,7; j=1,2,3 where £1 = (0,0) , £2 = (l, 0) , c = ~3 (0,1) , Assume that block effects are additive and error variance is constant, and test H : (1,21 O a : a ~ 6 21 H ~ 6 := == 31 ° against the ordered alternative (1,31 ' For convenience, use the logistic scores a. (j) I -e aU) = 2L_ := k+l j -2 1 . - -2- j==1,2,3; i==1, ... ,7 . Now calculate 3 7 T W1 = 7 L I c '1 a (R, ,) == i:=l j =1 J I J I a (R i==l i2 ) = !z and T W2 := 7 3 I I i=l j =1 7 I a(R· )=2 c '2a(R .. ) == I 3 J I J i=l To compute the variance matrix £w = n~, first calculate k C ~k -11 ?J' \ (c.-ck)(c.-c ), j~l ~J ~ ~J ~k and :£k - A~ III Then -11 ?J' 68 and Iw (1/2 , 2)' . 0: The transformation matrix of example 2.3 is used here to calculate ~ I w = £*Iw = (5/2 , 2) , and ~ QW - '"E*D""w'"E*' t Calculate - a a ~W(a) T' T' - ~W(a) ~(a) --- and = 0* 7/l2IT as before. ~W(a) o 0 D - o - ~-l o -- o -- ~W(aa) ~W(aa) ~W(aa) ~W(aa) ~W(aa) O} {2} 5/2 2 7/12(2) 7/12(1) 7/12(1) 7/12(2) 12/14 {2} O} 2 5/2 7/12(2) 7/12(1) 7/12(1) 7/12(2) 12/14 ea ~ ~ 1 ~W(a) ~ o:T ~W(a) ~-l -0 - 0 ~ -- T - ~W(aa)~W(aa)~W(a) 0* ~W(a) ~ =0 ~W(aa) ~ -D ~-l - D The -1/2 7/8 7/4 7/8 7 \.1r2 1)2 IT UI-LMP = rank test statistic 6.0 It is - ~W(aa)~W(aa)~W(aa) o {l,2} ~ -- 0 69 To evaluate the significance of T* W I . use the expression p{ ~ r (a) X ( a) 0~a~P where the D* ~N(a) rea) differ :;; x} are the same as in example 2.3 since D* and ~W(a) only by the multiplication of a scalar quantity. This yields a p-value of 1- 3.4 G (1) +~ (.985694) +i; (.985694) +~ (.950213)J = .021 . Asymptotic Power and Efficiency Considerations The results of sections 2.4 and 2.5 may be applied to the test of section 3.2 \vith only slight modification. {H } N Of alternative hypotheses where Again consider a sequence N = nk, and e (1) where Under the assumptions of section 3.2 ((2)-(5)), and following Chinchilli and Sen (198la), it can be shown that the sequence of probability measures under {H } N is contiguous to that under result is used to establish the limiting distribution of Iw as (2) where k '\ (c.-ck)(c.-c )', j~l ~J ~ ~J ~ k and H . O is the variance of This under 70 It is assumed that the lim N-1D ~W exists and is of full rank. N-+ro The asymptotic nonnull distribution of the VI T* statistic may be obtained directly from the results of section 2.4. W Define . (3 ) where mea) is defined similarly to (2.4.6). Then the asymptotic non- null distribution of (4 ) lim N-+ro where ing W is written as P{fTW~X}= I r*(a)p{/[k(a),i:I(a)] 0'=-a ,::Y x2 [k(a),i:I(a)] k(a) T* ~x} is a noncentral chi-squared random variable hav- degrees of freedom, and noncentrality parameter (S) The r*(a) are defined as in section 2.4. The asymptotic power function for the within block rankings test may be written as in (2.4.22). General expressions for power and efficiency are complicated, and this test will be included in the numerical study of chapter 4. For local alternatives, the methods of section 2.5 may be applied to look at local asymptotic power and efficiency. 3.5 Weighted Rankings The weighted rankings test of Salama and Quade (1981) was reviewed in Chapter I. This concept of utilizing the information contained in a comparison of the blocks is intuitively appealing, and it is desired to incorporate this concept into the LMP rank test framework. To do .. 71 this, the notation and assumptions of section 3.2 are adopted, and the additional assumption that f.(x .. ,lIy.) = f(X .. ,lIy.) (1) 1 1]] 1] J for i = 1, ... , n is made. To calculate the optimal scores for the weighted rankings proceclure, the joint density of the within block rankings and the variables used for weighting must be considered. Some measure of variability, e.g. the block range, is used to weight the rankings within each block. Let Then v. be the chosen measure of variability for the 1 9 i th block. is defined as (2) where Q. 1 is the rank of block rnakings The matrix of within v. 1 R is defined as before. In the following derivation, the block effects are taken to be euqal to zero for all i since both the ranks, and the invariant under tanslation. v. 1 are Under the null hypothesis the probability of observing a given set of within block rankings and block variability rankings can be written as n (3) po(E,9) = k k n ~ f(x .. ;0) r-r r-l- dx .. fE,9 f r-r i=l j=l 1J . i=] j=1 1] ••• Under the alternative this probability is written as (4 ) n f.. .f fr i=l j=l ~,g fr n f( x .. ; 1I Y .) dx .. 1J J i=] j=l 1J 72 To derive the locally optimal scores, first expand the function f(x .. ;~y.) ) g(x) = 1) in a Taylor series around the point -fl (x)/f(x) = O. Now letting as in Chapter 2, (4) may be written as (R,Q)=J···ffr -rrf(X 1J.. ;0) LIr-~y.g(x .. )+o(~)lfr TrdX. R n . J 1J ~. 1J (5) P A y ,LI ~ ~ ~ ~y. ) 0 0 ~';:S f 0 J 1 1 ) n k )~ n k ~n k IT ITf (X .. ; 0) 1 - L I ~y. g (x. 0) +o(~) IT TTdx .. r( R, Qj i j 1J L i=l j =1 J 1J i j 1J = ... 1 h.· f... f nk n k n k g(x .. )IT ITf(x .. ;O)IT ITdx. o+o(~) .. J R Q 1J . . 1J . . 1J 1 J N' ~ . 1 J 1 J =PO(R,Q)-~L ~ ~ Following the Neyman--Pearson lemma, form the ratio nk ~ Lh· ij J P y L\(R,Q) (6) f ... Jrg (x. .) ITn ITk f (x. . ; 0) orrn ITdx. k .+ ~---:::::.....::-'-=: 1 - PO (~, R,g ~ g) 0 j 1J i j 1J -----------(n k n k ••• JIT ITf( x. . ; 0) dx. R Q 1J 1J ~'~ 1 J 1 J 1J f IT IT 0 =: Zi S v. 1 0 Io J[n.LE ( g (x.1J.) IR, Q) ) + o(~) + o(~) (~) 0 • 1 are the order statistics from a sample of size corresponding to the that the 0 1 - ~ k y. J where the i pod.f. f (x .. ), i 1J = 1, ... ,n, j =: 1, ... ,k . are functions of these order statistics. mal scores are defined by k Note Then the opti- 73 (7) a Q.£ :::: E(g(zi£) 19) 1 I: [[:g(Zi2)m(Zi2Ivi)dZi~n[~:_~][rr(Vi)JQi-l o n-Q. 1 dIT (V.) x [1-IT(v.)] 1 where is the conditional p.d.f. of the m(z',e,lv.) 1 1 given the measure of variabi Ii ty for the marginal distribution function of LMP In order for a . th £th 1 order statistic block, and 1 is the IT (v.) 1 v .. 1 weighted rankings test to exist, the quantity say must be expressible as the product of two score functions, aQ . .Q, 1 c.Q, This will be the case if and (") ,) g(z·n)m(z. n!v.)dz' n Lx, Ix, 1 Ix, (8) :::: c x,n h(v .) o 1 _co where h(v.) some function of IS 1 v.. 1 not depends on the conditional density ~~ether this is the case or m(zi.Q,lv ). i If a .£ Q1 is not LY ·La the product of two scores then the statistics are of the form which is not a linear combination of the weighted rankings. . J. Q.R .. J 1 1 1J Thus, while it is possible to construct such tests, the weighted rankings procedure is not generally justifiable from the LMP criteria. Consider briefly the case when the k 2 and v. : : (k-l)s. 1 J= - 1 (x .. -x i ) 2 for i:::: 1, ... ,n. k i :: Xl" and v. 1 =: _ L (z 1].. -z.) . 1 1 J'= Denote the . th J 1J normal order statistic from a sample of size 2 are distributed normally, 1J \' L =: 1. X.. . written (see Durbin (1961)) as 2 k by z ... Note that 1J Now the order statistics may be 74 (9) Z .. ::: 1J where the u.. 1J X. 1 + u .. IV: 1J for 1 j:::l, ... ,k are symmetrically dependent random variables marginally distributed as the order statistics from a uniform k (-1,1) 2 distribu- k I u .. ::: 1, and I u .. ::: O. Geoj:::l 1J j:::l 1J randomly distributed points which lie on tion, and satisfying the conditions metrically, the u.. are k 1J the surface of a unit sphere of dimension independently of k - I, and are distributed v .. 1 Remembering that g(ziZ)::: side of (8) becomes E(Z. nlv.), 1 x, (10) E (Z , n 1 Iv '.) the left hand 1J and using (9) this can be written as Z. n Ix, for normal ::: IV: E (u .. ) . 1 1J Ix,] In relation to the expression in (8), expected value of the jth afore mentioned constraints. X.. , h(v.) ::: 1 IV:, 1 and is the uniform order statistic subject to the Thus, while the locally optimal weighted rankings scores exist in this case, their calculation is quite complicated. The following ad hoc statistics are suggested on the grounds that they are intuitively related to the cases, depending on the form of LMP a .£, Q1 statistics, and in some may satisfy the LNP Define the vector of weighted rank statistics as (11 ) where k n (12) TQm ::: I i:::l d (Q.) ] I j:::l c. a(R .. ) Jm 1J for m:::l, ... ,p. criteria. 75 Note that the calculation of involves weighting the within block ranking statistic The d(Q.). 1 in (3.2.12) 1 that f(x .. ) . The density 1J q. 1 be the n(v.) 1 . th 1 .th p.d.f. will of course depend on n(v.). 1 d(Q.) _ E{-ll¥(V i ;O) ] n(v.;O) 1 I Q} = ~ n(v.), the 1 block, rather 1 order statistic from a sample of 1 variables all having the (13) the differ- is based on d (Q.) of the chosen variability measure for the Let f(x .. ) . 1J random n Then E{-n'(qi;O)} n(q.;O) 1 While these scores are intuitively appealing, -e a (R .. ) , 1J ence being that the calculation of the p.d.f. with the block score are defined similarly to the d(Q. ) LMP their calculation depends on obtaining a closed form for the density n (v. ), will in most cases be quite complicated. is the range of the .th 1 block, the distribution function of II(v.) = (14 ) When 1 v. 1 V. 1 1 and this is expressed as kjrOO f(x .. )[F(v.+x .. )-F(x .. )] k-l dx .. 1J 1 1J 1J 1J Quat ing from Sarhan and Greenberg (1962) \\lho give this expression along with the c.d.f. of the midsum' "These beautiful formulas are not of much use since, in general, the probability functions F(w-x) c;mnot be expressed by F(x)." F(x+v) and This is the case when the x.. 1J are distributed as logistic random variables. Calculation of the d(Q.) 1 IS possible for the case when the are distributed as standard normal random variables, and v. 1 k _ 2 2 taken to be (k-l)s. For this situation the L (x .. -x.) 1 distributed as 2 X _ k l . I J= 1J 1 x.. 1J is v. 1 random variables, and the block scores are are 76 calculated as (15) E{ -nl(qi;O)} k-3 {I} 1 - - - - E - +n(q. ;0) 2 q. 2 1 where 1 . the l.th or d er statIstIc . . f rom a samp 1e o f n IS q. 1 abIes having the chi-squared distribution with k-l random vari- degrees of freedom. Using the approximation E{- TI I (16) 'IT (q i ; ()) } (q. ; 0) 1 (see Cox and Hinkley (1979) p. 189) where function of a is now the distribution random variable, (15) may be written as l 1 n'(v.)/n(v.) 1 e- l' k-3 rIT -1 - Qi )) -1 + -1 n+l 2 . 2 d (Q. ) (17) Here, since IT 1 is a drecreasing function in weight is given to the less variable blocks. v. , Of course when (15) is a constant, and the blocks are weighted uniformly. can b:.C:lf"iat::.s,:,:~~y and 1 ~=l IJ 1 when the Xij 1 more k The == 3 d(Q.) 1 are normal random variables, J This result is in conflict with the numerical results of Silva (1977), and Salama and Quade (1981). Their work indicates that more weight should be given to the more variable blocks when the data are normal and the sample variance is used to measure within block variability. While the ad hoc statistics of (12) are intuitively related to the LMP statistics, it must be remembered that the resulting scores 77 depend on the choice of density, and the choice of within block variability measure. appropriate. For certain cases, this ad hoc statistic may not be In Chapter 4 the above case will be examined numeri- cally, and some conclusion will be sought as to the weighting of the within block rankings. 3.6 Exampl c::. For purposes of illustrating the weighted rankings test the LMP within block ranking scores are used as in example 3.3, and the block weighting are selected arbitrarily. While the resulting test will not be the LMP weighted rankings test as defined in section 3.5, the UI principle is used to produce a valid test against ordered alternatives. The data of example 3.3 appear below. of interest are the same as in section 3.3. ro'h .th bl OC k.• and tel Q.1 Or The model and hypotheses Let v. 1 be the range In their paper, Salama and its rank. Quade (1981) suggest using linear weights. These weights are adopted here, and denoted by (1) b(Q.) 1 == for Q. 1 i == 1, ... ,7 . Then the weighted rankings statistics are defined by 3 7 I (2) i==l where the a (R .. ) 1 in (3.3.3). J b (Q. ) 1 I j=l c. a(R .. ) Jm 1J m = 1.2 are the logistic scores, and the c. Jm are defined 7P> Block Treatment 1 2 3 4 5 6 7 1 38 51 39 43 57 49 40 2 54 63 46 56 47 62 50 3 45 79 SR 53 52 72 55 Range 16 28 19 13 10 23 15 4 7 5 2 1 6 3 Q.1 Calculations yield IQ : : [~ QJ' 2' 2 which has variance QWk being defined as in section 3.3. The transformation matrix needed to test for order is again and the transformed vector, and its variance are E*T~Q ~ ~ QQ The v T ~Q(a)' and D* (a) ~~Q ::: E*D~Q~E*' ~~ ::: 35 [2 3 lJ U for the various sets a are presented below. e 79 '" ~ 1 a - =T ~-1 -D - [) '" -- T - -Q(a) -Q(a) -Q(aa)-Q(aa)-Q(a) D* ~ =D -Q(a) :q(aa) -0 ~-l - 0 ~ -- 0 - ~(aa)~(aa)~(aa) o {l,2} The 31/4 35/2 4 35/2 35 (13,21/2)' UI 3 r2 n II ~ statistic is given by \'{(T! 0*-1 T )I(TNQ(a) "'Q(a)~Q(a)-Q(a) T* = Q L a = 8.1571 . To evaluate the significance of where the l' <O)} >0)1(0* - T -Q(a)~Q(a) -- - '" (a) TO use the expression are again the same as in example 2.3, and this yields a p-value of 1 - G (1) + ~ (.995711) + ; (.983068)J = .007 . For the sequence of alternatives in (3.4.1), the limiting distribm:ion of (3) where (4) IQ is 80 where 2 8 Q lim N-1D NQ N-+= and = k ~k = ), .. \L (c.-ck)(c.-c ~J ~ ~J ~k J =1 exists and is of full rank. If ~(a) assuming that the is a matrix such that ~ v (5) IQ(a) = m(a)IQ ' then the asymptot ic nonnull di stribution of T* is written as Q L r*(a)p{x 2 [k(a) ,li(a)] ~ x} (6) a where (7) and the 3.7 r*(a) are defined as in section 2.4. Aligned Rankings The aligned rankings procedure (see Puri and Sen (1971)) makes use of a transformation to subtract off the block effects in the randomized complete blocks model. ranked from 1 to N, Then the aligned observations are and statistics are calculated in an effort to compare observations among blocks as well as among treatments. As in the weighted rankings procedure, it is hoped that some of the information lost as a result of considering the within block rankings alone will be recovered. Define the aligned observations as (1) Y.. = X.. - X. 1J 1 J 1 i=l, ... ,n, j=l, ... ,k. . 81 To derive the LMP aligned rank test, the joint density of the must first be considered. densities as the Then the density rro ri TT i=1 j=l k n (2) f(v) :0: /.., n IS k-variate are correlated within each block, and indepen- Y.. IJ dent among blocks. This density is the product of Y .. IJ may be written as f (x. +y .. ; 6 y. ) dx . J 1 IJ J 1 _00 = ro f .. • _00 Let peE) " J IT f ex. +y .. ; 6y J.) TTdx. . 1 J 1 _00 n k IT as in (3.5.5). f(x.+y., ,.t,y.) J] 1 Then peE) . in a Taylor series around ] IT _00 ~ =J···f R f"V = 0 J ' _00 1 L:oo _00 r oo 6y. is written as =f· R.. f IItfOOj ... JooIT. ,IT f CX. +y .. ; 1 1) ) co~n k 1 J J J 0) (l-6y . g (x. +y .. ) +0 (6)) Trdx dy J 1 1) . 1 ~ 1 l ~ n k n -, 1 -.l Ii ... ) r . ""IT.IT f(x.+y .. ;0) I 1-2 L6yog(x +y 0)+0(6) ITdx.ld;r 1 I) JON r rN . 11 ._00 g(x +y ) r rt _00 = -f' (x +y )/f(x +y ) r r£ r r£ Proceeding as before, form the ratio (4) 1 1 ooJr IIlfoo ... foo i ]IT fCX. +y .. ; 6y.) frdXJd l ' 1 1) J i 1 R f"<o..J where 1J be the probability of observing a given set of aligned rank- ings, and expand (3) peE) =Jr. roon rN for r=l, ... ,n, t=l, ... k. 82 and the locally optimal scores are of the form (5) These scores are not easily expressed in a closed form since their actual the computation depends on the joint distribution of Y.. 1J X. 1 and all However, the following approximation may be used. 'So Let (6) where F is the c.d.f. of the X.. 1J 'So While the scores of (6) are not strictly LMP, they provide an adequate approximation since the block effects are taken to be null. 3.8 Example The data of sections 3.3 and 3.6 are again used to calculate an example. The observations are first aligned by subtracting off their block averages as in (3.7.1). ranks appear below. The aligned observations, and their Note that there is one tie, between Yll and Block 2 Treatment 1 3 -13.3(1) - 8.7 (3) 8.3(18) - 1.3(9) - 1.7(8) -7.7(5) 2 - 3 .7(10) 14.7(21) 10.3(19) 4 -7.7(6) 5 5 (1 5) -12(2) 5.3(16) -5 (7) 2.3(14) 6 o(11) 7 -8'\4) 1 (12) 10 7 (13) 11 (20) 6.7(17) but since both the observations are in the same treatment group it does not matter how the tie is broken. The model and hypotheses of section 83 3.3 are retained, and tested here. Define (1) where £1 £2 If Dj 1 = F ej - e1 ' an c1 t est (0,0) i ::: (l, 0) I = (0,1)' £3 and ::: H0: '" 2 1 = '" 31 = 0 vs the scores in is taken to be the standard normal c.d.f. (3.7.6) become (2) -e i=1, ... ,7" j=1,2,3, and the aligned rankings statistics are defined by 7 T ( 3) The vector Am = I 3 L i=l j=1 c cjJ- jm 1[R-2l. .. ) m=1,2. N+1 IA IA and its variance Q A ::: (.8,5.1) I , is calculated as r2 = 2.66, ' L:'l where (4) is the same as in section 2.3, and is defined as ~ nk 2 0A'" _. (n(k-l))-1 \\ (aeR .. ) - aeRo )) LL ij I) I. 84 where aCR. ) 1. 1 k k L aCR I).. ) j To test against the ordered alternative, make the following transformation: I A = E*T ,-,- ~l ~ ~A and E*D~A~E*' ~ fACa )' a and Q;Ca) ~ ':i. 1 ~A(a) = T = 2. 66 for the various sets 'v-l ~ - 0 -- T ~ -0 - ~A(a) ~ACaa)~A(aa)~ACa) o o {l} 3.4 {2} 2.2 {l, 2} ~ a are presented below. ~ 0* ~ACa) ~ =0 ~ACaa) -0 ~-l - D ~ -- 0 - ~ACaa)~ACaa)~ACaa) 3.99 (5.9,5.1)' The UI-aligned ranking statistic is given by T* = \' A L a {CT' D*-l T )I(T~A(a) ~ACa)~A(a)~ACa) ~s 9,5.1)(·125{i > 0)1(0* - - ~ T - < OJ} ~A(a)~A(a) - ~ 'fl [~: ;1] ::: 7.6825 , and its approximate p-value, calculated as in the previous examples, is e- 85 1 - ~ (1) +-} (.994424) +~ (.978533)J = .009 . For the alternatives of (3.4.1), the limiting distribution of T ~A is (5) where the lim N- 1QA exists and is of full rank. Let mea) be the N-7= matrix such that bution of rAta) = m(a)I . A Then the asymptotic nonnull distri- is written as (6) where (7) and the 3.9 r*(a) are defined as in section 2.4. Testing for Order in an Analysis of Covariance As in section 2.8, ur rank tests for the analysis of covariance can be constructed quite easily by combining the ur principle existing methods. with For the within block rankings case, Gerig (1975) has proposed a multivariate test which can be readily adapted to form the ur test. Let X.. 1J jth treatment, be the primary variate in the i i = 1, .. ,n. Y.. = (Y~., ... ,Y~.) '. ~lJ 1.1 1) j = 1, ... ,k. th block receiving the and define the covariates as Observations are ranked for each variate within blocks, and this ranking is denoted by R~ ., s 1J = I, ... , p where p = q+l. 86 1 The ranks S :: R.. 1) 2, ... ,p s R.. , correspond to the primary variate, and the ranks correspond to the covariates. 1 nk II n.. T :: - (1) m 1) Define the statistics 1 c. a(R .. ) 1) Jm 1) and 1 nk s == c. a(R .. ) m n.. Jill 1J t U (2) n s==t+l, t==l, .... q. 1J Let and Then ~ == (I' .g')', ~ is a -n (4 ) ~ ( 1 \J identity matrix, (k-l) x (k-l) CCa .. B))), V :: ((V)), rs Var{~}:: ~ ~k-l - lk-lj~k-l matrix of ones, the symbol 1J~ 1 1 q q (U 1 • ... ,Uk _1 ' ... , U1 ' •.. , Uk _1) , • and has variance 6 .- 1 [1 (3) !2 :: ) @~ where ' J ~k-l is a (k-l) @ denotes the Kronecker product x (k-l) CA @ ~ :: and nk \', r s V rs :: n(k-I) LL a(Rij)a(R ij ) ij 1 r,s::l, ... ,p. Writing (5) the vector of statistics adjusted for the covariates is defined as (6) and has variance (7) T ~a 'T' 1 - 87 Now the UI statistic can be calculated as before. For the case of weighted rankings, the same method may be used after weighting the within block rankings with the appropriate block weights. The same p variates within a block. block weights are used for all A similar method for aligned rankings is presented by Puri and Sen (1971). cell be Again let the p-variate response vector for the Z .. = (X .. , Y .. ) 1J '~lJ observations are (i,j) th vvhere ~lJ I q Y .. = (Y .. , .•. ,Y . . ). k ~lJ 1J 1J 1 Z~. ;:; ~lJ Z.. - -k \ Z. " ~ ~lJ J aligned observation for the s th vat ions for each variate being ranked from statistics T , Nm 1 q ~Nm = CSNm",·,SNm) and (8) T R~. and ~lJ 1J (i,j)th The aligned is the rank of the variate, the aligned obser1 to nk = N. Define the where I nk 1 = c. a (R .. ) Nm n .. Jm 1J 1J n and 1 nk (9) = -- II c. a (R: . ) Jm 1J n ., 1J Al so, define the p x p permutation covariance matrix as 1 nk --C'k----l) II a(R:.)aCR~.) n . . 1J 1J (10) 1J (11) define (12) s=t+l, t=l, ... ,q . T* Nm V (EN) = N r,s=l, ... ,p. 88 IN = (TNI ,·· .,TNk _1)', Then the vector of adjusted statistics is and its variance is D 1[I _[_1) k-I (13) ~ = n IVN,11.2 J ~k-l ~k-lJ where (14) Once V N,11.2 T* ~N Q and in the usual ==V N,ll -V -1 V V ~N,12~N,22~N,21 have been obtained, the UI statistic is calculated manner. 3.10 The 2 Factor Experiment Replicated in n Complete Blocks Consider the situation described in section 2.10, only now there is one observation per cell for each of n 2 factor experiments. To test for order among the levels of one of the factors, the observations are first summed over the levels of the other factor, and then one of the 3 methods described in this chapter can be applied. Let i==l, .... n (1) j=I, ... ,p, k = 1 .... ,q , where S. 1 level of factor tor T. I S J (2) 2. . th is the 1 1, and block effect, Yk T. J is the effect of the is the effect of the The usual side conditions hold. define q I y .. = X"k 1J k=l 1J k th . th J level of fac- To test for order among the e- 89 The Y.. 's can be regarded as 1) function where G(y .. ) 1J dom variables. nk random variables with distribution G is the c.d.f. of the sum of q Li.d. ran- Now one of the previously described complete blocks methods may be used to test for order among the Similarly, the levels of factor 2 p levels of factor 1. can be tested for order. 3.11 Summary_ In this chapter, the UI-LMP rank test method has been extended to tests against ordered alternatives in the complete blocks design. For the within block rankings case, the to the test of Chapter 2. UI-LMP rank test is similar For both the weighted rankings, and aligned rankings procedures, no general closed forms have been obtained for the LMP scores. suggested. In both cases approximations to the LMP scores have been Some computations suggest care should be exercised when arbitrarily selecting block weighting scores for the weighted rankings test. Some further numerical work will be presented in chapter 4. Finally, in sections 3.9 and 3.10, methods have been suggested for testing for order in the analysis of covariance, and the ment replicated in n complete blocks. 2 factor experi- CHAPTER 4 Monte-Carlo Results 4.1 Introduction Chinchilli and Sen (1981 a,b) report via large sample theory that the UI statistic follows a weighted chi-squared distribution which is refered to in the literature as the -2 X distribution. The purpose of this chapter is to investigate the power of the UI-LMP rank tests discussed in Chapters 2 and 3 for samples ranging in size from 30 to 125 using the weighted X 2 two ad hoc FORTRAN programs. approximation. Simulations were run using The first program compares the UI-LMP rank test of Chapter 2 with Jonckheere's test, and the Normal Scores test. The second program compares the tests described in Chapter 3 for the analysis of complete blocks. Page's test. These tests are also compared with A more detailed description of the simulations and their results is presented in sections 4.2, and 4.3. 4.2 Simulated Experiments for the One-Way Layout For each of the following 32 cases, sao independent experiments \liere simulated hy generating normal random samples and calculating the UI-LMP rank statistic, Jonckheere's statistic, and the Normal Scores statistic for each sample. imations, Using the appropriate large sample approx- the proportion of rejections at the recorded for each test. Note that for k>3 a= .05 level was the approximations of 91 Gupta (1963) are used to calculate the UI critical values. Simula- tions were TIln for different comhinations of the number of treatments, number of observations per treatment (equal sample sizes were used), and type of alternative. Let k be the number of treatments, and observations per treatment. m be the number of Three cases are considered: the case when all means are equal, the case when the means are equally spaced, and the case when the means are unequally spaced. m considered are k = 3,4,5, and The values of m = 10,15,20,25. When k k and = 3, unequal spacing is a possibility, but since the UI statistic is concerned with k-l parameters it is not very interesting. Hence, 32 situations are examined. Table 1 gives the proportion of rejections for all combinations of k and m when the vector of treatment means is null. Tables 2a and 2b give the results when the treatment means are equally spaced. To generate Table 2a, mean vectors of the form used where 2N -~ k = (1,2, ... ,k) 3,4,5. -~ N were used. (0,1,2,5)' -~ (1,2 •... ,k) were For Tab Ie 2b, mean vectors of the form The unequally spaced means case is repre- sented by Tables 3a and 3b. were N and tive mean vectors were For -1 N k::: 4, the respective mean vectors (0,1,4,10), and for N-~ (0,1,2,2,5), and k:::5, the respec- N-~ (0,1,4,4,10). 92 TABLE 1 Proportion of Rejections (a = .05) for Case of Equal Means 93 TABLE 2a (0. := • 05) Proportion of Rejections for Case of Equally Spaced Means 94 TABLE 2b (ex = .05) Proportion of Rejections for Case of Equally Spaced Means k m Jonckheere Normal Scores UI -LMP 3 10 .440 .356 .390 3 15 .478 .408 .402 3 20 .440 .400 .382 3 25 .464 .456 .404 4 10 .670 .594 .576 4 15 .656 .598 .552 4 20 .680 .652 .558 4 25 .712 .678 .578 5 10 .848 .800 .730 5 15 .854 .824 .722 5 20 .866 .832 .754 5 25 .838 .812 .744 e , 95 TABLE 3a (ex = .05) Proportion of Rejections for Case of Unequally Spaced Means 96 TABLE 3b (a. = .05) Proportion of Rejections for Case of Unequally Spaced Means 97 The rejection proportions shown in Table 1 should all be around .05. .. However, for the Normal Scores test all twelve proportions are less than .05 and for the UI-LMP test all twelve are greater than .05. This implies the UI-LMP test has an unfair advantage over the other tests in the power comparisons, and the Normal Scores test is handicapped. This also indicates that those two large sample approximations are not good for the sample sizes tested. Looking at Tables 2a-3b, the UI-LMP test has not done very well since its rejection proportions are the smallest. A priori it was hypothesized that the UI-LMP test would be most powerful for the case of unequally spaced means, and at least as powerful for the case of equally spaced means. It is possible that the weighted mation would be better for larger sample sizes. bons for rea) 2 X approxi- Also, the approxima- might have added further variation to the asymptotic values. 4.3 Simulated Experiments for the Complete Blocks Design The methods of section 4.2 were also used to simulate experiments for the complete blocks design. each sample: Five statistics were calculated for and Page's statistic, is the statistic of section 3.2, T* T* A T* A where T* W is the statistic of section 3.7, T* T OL is based on a linear weighting as in section 3.6, and the statis- tic T OC Now m corresponds to the number of blocks. QL and QC are weighted rankings statistics. The statistic and is the same as in (3.5.12) with block weights as in (3.5.17). 98 TABLE 4 (a = Proportion of Rejections .05) for Case of Equal Means k ill Page T* W T QL T QC T* 3 10 .046 .078 .082 .078 .090 3 15 .042 .084 .078 .084 .082 3 20 .056 .078 .070 .072 .058 3 25 .054 .060 .048 .058 .048 4 10 .060 .090 .080 .056 .080 4 15 .046 .064 .060 .066 .054 4 20 .058 .058 .056 .082 .060 4 25 .054 .086 .080 .048 .070 5 10 .052 .078 .080 .066 . 082 5 15 .058 .064 .066 .060 .060 5 20 .060 .068 .072 .052 .070 5 25 .056 .086 .040 .088 .088 A e . 99 TABLE Sa (a= .05) r e Proportion of Rejections for Case of Equally Spaced Means k m Page T* W T QL T QC T* 3 10 .172 .150 .192 .] 48 .196 3 15 .156 .184 .186 .184 .204 3 20 .176 . ] 54 .178 .150 .184 3 25 .182 .164 .154 .164 .168 4 10 .278 .220 .206 .160 .218 4 IS .274 .250 .240 .166 .262 4 20 .200 .174 .198 .150 .210 4 25 .244 .194 .218 .142 .238 5 10 .328 .228 .252 .166 .274 5 15 .354 .246 .254 .146 .298 5 20 .344 .286 .286 .150 .300 5 25 .312 .244 .250 .122 .274 A 100 TABLE Sb (0.::= .05) Proportion of Rejections for Case of Equally Spaced Means 101 TABLE 6a (ex = .05) r e Proportion of Rejections for Case of Unequally Spaced Means k ill Page T* w T*QL Toe T* 4 10 .504 .394 .396 .314 .454 4 15 .462 .394 .410 .270 .454 4 20 .454 .404 .414 .218 .456 4 25 .444 .356 .390 .202 .424 5 10 .388 .322 .324 .188 .376 5 15 .368 .314 .306 .136 .340 5 20 .352 .304 .336 .178 .348 5 25 .380 .326 .316 .134 .352 A 102 TABLE 6b (0,::= .05) Proportion of Rejections for Case of Unequally Spaced Means 103 Table 4 shows rejection proportions greater than .05 for all of the VI statistics. In Tables Sa-6b, T A compares favorably with Page's test, but the difference in their null rejection proportions must be considered. Page's test has higher rejection proportions than the other three VI tests. Comparing the VI tests with each other yields a clearer interpretation. Here the aligned ranking statistic T* A has consistently =3 higher rej ecdon propoTtions than the other VI statistics. When k T* QL k=4 and 5. is better than T* IV' and perhaps slightly better when Also some light has been shed on the question raised in section 3.5 as to whether the blocks should be weighted inversely for the weighted rakings statistic when the data are normal and the block variances are used to determine the block rankings. yields far lower rejection proportions that The statistic T5L' These results sup- port the findings of Silva (1977), and Salama and Quade (1981). poor performance of T5c T5c The may be due to the fact that some blocks are weighted negatively, some blocks are weighted positively, and some of the blocks may be given a weighting of O. Thus, rather than adding strength to the analysis, these block weightings cancel out the information available from considering the blocks. Adding a constant so that these weights are all positive should be tried in the future. 4.4 Summary Simulations have been run in an effort to investigate the asymptot- ic 2 X power of the VI tests described in Chapters 2 and 3. approximations used for the VI The wSighted statistics do not appear to be 104 very stable for the sample sizes selected. However, the D1 tests for the complete blocks design may be compared with some degree of confidence. Here the UI aligned rankings statistic appears to be doing the best job. CHAPTER 5 Recommendations for Future Research The UI-LMP rank test method presented in Chapter 2 has been extended to tests against ordered alternatives in the analysis of complete blocks when within block rankings are used. However, for both the weighted rankings, and aligned rankings procedures, no general closed forms have been obtained for the LMP scores. cases have been discussed. Some special One area of research may involve further investigation of such special cases. Another problem which needs more work is that of constructing UI-LM7J rank tests for the analysis of covariance. In both Chapters 2 and 3, ad hoc procedures have been sug- gested which do not have the LMP property. To construct UI-LMP tests, the conditional distribution of the principal variate given the covariates must be considered. In sections 2.10 and 3.10, analysis of the two factor experiment has been discussed. An interesting area of research deals with test- ing for order in higher order layouts. Factorial experiments are effi- cient in the sense that they allow for simultaneous investigation of two or more factors. It is conceivable that an investigator may hypothesize some ordering among the levels of one or more factors. Currently there are no tests against ordered alternatives in higher order layouts, and research could be conducted toward this end. 106 Initially the problem of how to define the ordered alternatives must be solved. The ordering of interactions should be considered. Once this problem is solved efforts should be made to apply the UI-LMP rank test procedure. Perhaps weighted rankings can be incorporated, the weightings relating in some way to the other factors. Consider as an example the two factor model with main effects a. 1 that and La. . 1 1 S. and interaction J = LS' = .') J L(aS) .. . 1J = 1 (as) ... I) L(aS) .. . 1J J The usual side conditions are = O. To define the ordering for the levelsof a given factor, the interaction of the factors should be taken into account. Because of the above conditions, the usual con- cept of ordering is not meaningful. Perhaps a solution to this problem may be obtained using a technique simi 1ar to profi I e analys is. Now, instead of mu ltivariate response vectors for various groups, the levels of another factor are of interest. Standard plots of means for the levels of one factor at the vari- ous levels of another factor to show interaction in a two factor ANOVA are quite similar to the plots associated with profile analysis. A discussion of profile analysis is found in Norrison (1976). The questions of interest concern parallelism of group means, differences among groups, and differences among means within groups. testing these hypotheses are well known. Methods for These same questions are applicable to the problem at hand. Thus, the problem of testing against order in higher order layouts can be investigated in light of the methods of profile analysis. Most recently, Chinchilli and Sen (1982) have considered multivariate linear rank statistics for profile analysis. They make use of the 107 ur principle while assuming that the response-sample interactions are null, and also advocate the use of a preliminary test for these interactions. In addition, more numerical work should be done to further .. investigate the asymptotic power of the UI-LMP rank test. While some useful resuJ 1:5 have beE'n presented in Chapter 4, it wou] d be helpful to run the simulations for some much larger sample sizes. Also, simulations should be done to investigate the power of the analysis of covariance methods presented in Chapters 2 and 3. ent, At pres- not much has been written in this important area. Finally, in the parametric case beta approximations are usually E approxima- available for small sample sizes. These are known as tions (see Barlow et al. (1972)). 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