Deba Prasad Mandal
Assistant Professor,
Dept. of Zoology,
West Bengal State University.
Berunanpukuria, PO Malikapur, Kolkata-700126.
Telephone: 09830505042 / e-mail: [email protected]
EDUCATION
2001-2007
PhD. , Bose Institute, Kolkata, India.
2000-2002
MSc in Zoology; University of Kalyani, Nadia, West Bengal, India.
EMPLOYMENT
04-06-2009 - till date
West Bengal State University.
28-11-2006 - 03-06-2009
Durgapur Government College
AWARDS & FELLOWSHIPS

Junior Research Fellowship from UGC-JRF (NET-July 2001)

Junior Research Fellowship from CSIR-JRF (NET-December 2001)

Qualified GATE (2001) [AIR – 301 Percentile- 84.36]
RESEARCH INTERESTS
Molecular Oncology, Signal Transduction,
PUBLICATIONS
Selected peer-reviewed publications (Five best publications in chronological order)
1. Bhattacharyya A, Mandal D, Lahiry L, Sa G, Das T. Black tea protects immunocytes
from tumor-induced apoptosis by changing Bcl-2/Bax ratio. Cancer Lett. 2004; 209:14754.
2. Bhattacharyya A, Lahiry L, Mandal D, Sa G, Das T. Black tea induces tumor cell
apoptosis by Bax translocation, loss in mitochondrial transmembrane potential,
cytochrome c release and caspase activation. Int J Cancer. 2005; 117:308-15.
3. Mandal D, Bhattacharyya A, Lahiry L, Choudhuri T, Sa G and Das T. Failure in
peripheral immunosurveillance due to thymic atrophy: Importance of thymocyte
maturation and apoptosis in adult tumor bearer. Life Sci. 2005; 77: 2703-16.
4. Mandal D, Lahiry L, Bhattacharyya A, Chattopadhyay S, Siddiqi M, Sa G, Das T. Black
tea protects thymocytes in tumor-bearing animals by differential regulation of
intracellular ROS in tumor cells and thymocytes. J Environ Pathol Toxicol Oncol. 2005;
24:91-104.
5. Mandal D, Lahiry L, Bhattacharyya A, Bhattacharyya S, Sa G, Das T. Tumor-induced
thymic involution via Inhibition of IL-7R and its JAK-STAT signaling pathway:
Protection by Black Tea. Int. Immunopharmacology. 2006; 6: 433-44.
6. Mandal D, Bhattacharyya S, Lahiry L, Chattopadhyay S, Sa G and Das T. Black teainduced decrease in IL-10 and TGF- of tumor cells promotes Th1/Tc1 response in
tumor-bearer. Nutrition and Cancer. 2007, 58(2); 213-221.
7. Bhattacharyya A, Mandal D, Lahiry L, Bhattacharyya S, Chattopadhyay S, Ghosh UK,
Sa G, Das T. Black tea-induced amelioration of hepatic oxidative stress through
antioxidative activity in EAC-bearing mice. J Environ Pathol Toxicol Oncol. 2007;
26(4):245-54.
8. Bhattacharyya S, Mandal D, Saha B, Sen GS, Das T, Sa G. Curcumin prevents tumorinduced T-cell apoptosis through Stat-5a-mediated Bcl-2 induction. The Journal of
Biological Chemistry. 2007; 282(22):15954-64.
9. Bhattacharyya S, Mandal D, Sen GS, Pal S, Benerjee S, Lahiry L, Finke JH,
Tannenbaum, Sa G and Das T. Tumor-Induced Oxidative Stress Pertrubs Nuclear Factor
–B Activity-Augmenting Tumor Necrosis Factor--Mediated T-Cell Death: Protection
by Curcumin. Cancer Research. 2007, 67: (1).
10. Lahiry L, Saha B, Chakraborty J, Bhattacharyya S, Chattopadhyay S, Banerjee S,
Choudhuri T, Mandal D, Bhattacharyya A, Sa G, Das T. Contribution of p53-mediated
Bax transactivation in theaflavin-induced mammary epithelial carcinoma cell apoptosis.
Apoptosis. 2008; 13(6):771-81.
11. Sen GS, Mohanty S, Hossain DM, Bhattacharyya S, Banerjee S, Chakraborty J, Saha S,
Ray P, Bhattacharjee P, Mandal D, Bhattacharya A, Chattopadhyay S, Das T, Sa G.
Curcumin enhances the efficacy of chemotherapy by tailoring p65NFκB-p300 cross-talk
in favor of p53-p300 in breast cancer. The Journal of Biological Chemistry. (2011) 9;
286(49):42232-47.
12. Patra K, Bose S, Sarkar S, Rakshit J, Jana S, Mukherjee A, Roy A, Mandal DP*,
Bhattacharjee S*. Amelioration of cyclophosphamide induced myelosuppression and
oxidative stress by cinnamic acid. Chemico-Biological Interactions 195 (2012) 231–239.
13. Bhattacharjee S*, Mandal DP (2012). Angiogenesis modulation: the "spice effect". J
Environ Pathol Toxicol Oncol; 31(3):273-83.
14. Jana S; Patra K; Sarkar S; Jana J; Mukherjee G; Bhattacharjee S*; Mandal DP* (2014).
Anti-tumorigenic Potential of Linalool is accompanied by Modulation of Oxidative
Stress: An in vivo Study in Sarcoma-180 Solid Tumor Model. Nutr Cancer. 2014;66
(5):835-48. (IF- 2.7).
Book Chapters
Lahiry L, Mandal D, Bhattacharyya A, Sa G & Das T. Cancer prevention by cancer regression
and rejuvenation of host defense system: Dual role of tea.: Medicinal Properties of TEA (Eds.
B Banerjee & TC Chaudhury) Oxford & IBH Publishing Co. Pvt.Ltd. New Delhi 2005:
Chapter 7: 89-112. Also published in Tea Therapeutics (Eds. B Banerjee & TC Chaudhury)
Science Publishers Inc., New Hampshire, USA. (2005)
PATENTS
1. “A cancer chemotherapeutic agent/formulation, manufacture and use thereof”, an
international patent (PCT Int'l Appl. no. PCT/IN2013/000593) for Bose Institute, Kolkata and
West Bengal State University, Barasat, 24 PGS (N). Name of Inventors : 1)DR.
SUBHRANGSU CHATTERJEE 2) DR. ANIRBAN BHUNIA 3)DR. DEBA PRASAD
MANDAL 4) DR. SHAMEE BHATTACHARJEE
European Phase Patent Application No. 13841638.3 dated 19th March 2015
US national Phase Patent Application No. 14428836 dated 17th March 2015
Australian Phase patent Application No. 2013322120 dated 5th January 2015
2. Indian patent (1120/KOL/2012 A) entitled “G-QUADRUPLEX STABILIZING AGENTS
AND FORMULATIONS INVOLVING THE SAME”. for Bose Institute, Kolkata and West
Bengal State University, Barasat, 24 PGS (N). Name of Inventors : 1)DR. SUBHRANGSU
CHATTERJEE 2) DR. ANIRBAN BHUNIA 3)DR. DEBA PRASAD MANDAL 4) DR.
SHAMEE BHATTACHARJEE
SEMINARS/CONFERANCES ATTENDED (National and International Conferences)
1. Black Tea as an immunological booster against immunospuppressive effects of Cancer
and anti-cancer drugs. Deba Prasad Mandal, Arindam Bhattacharyya, Sreya
Chattopadhyay, Gaurisankar Sa and Tanya Das. Society of Biological Chemist (India)
Kolkata Branch Seminar (India) Kolkata Seminar at Santiniketan 2002
2. Monitoring host immune response vis-à-vis cancer development: A mechanistic
Approach. Deba Prasad Mandal, Lakshmisri Lahiri, Arindam Bhattacharyya, Sreya
Chattopadhay, Uttam Ghosh, Tathagata Choudhuri, Suman Pal, Gaurisankar Sa and
Tanya Das. Annual Meeting of Immunology Study Group-West Bengal and Current
Trends in Immunology, Bose Institute,Kolkata, November 2002.
3. Role of black tea in countering tumor-induced thymic involution. Deba Prasad Mandal,
Lakshmisri Lahiri, Arindam Bhattacharyya, Sreya Chattopadhay, Uttam Ghosh,
Tathagata Choudhuri, Suman Pal, Gaurisankar Sa and Tanya Das. Annual Meeting of
Immunology Study Group-West Bengal CNCRI, Kolkata, September 2003.
4. Amelioration of tumor-induced immuneosuppression by black tea: A search for the
mechanism. Deba Prasad Mandal, Lakshmisri Lahiri, Arindam Bhattacharyya, Uttam
Ghosh and Tanya Das. National Seminar on Recent Advances in Stress Physiology,
Toxicology and Immunology, University of Kalyani, November 2003.
5. Black Tea prolongs the immune resistance against developing tumor countering the
tumor-induced immunosuppression. Deba Prasad Mandal, Arindam Bhattacharyya,
Lakshmisri Lahiri, Sankar Bhattacharyya, Uttam Ghosh, Gaurisankar Sa and Tanya Das.
6.
7.
8.
9.
23rd Annual Convention of the Indian Association for Cancer Research. Special
Symposium on Anti-cancer Drug Development, ACTREC. Navi Mumbai, January 2004.
Black Tea: Can it be a candidate for countering tumor-induced immunesupprrssion?
Deba Prasad Mandal, Arindam Bhattacharyya, Lakshmisri Lahiri, Sankar Bhattacharyya,
Uttam Ghosh, Gaurisankar Sa and Tanya Das. Society of Biological Chemist (India)
Kolkata Branch Seminar, May 2004.
Black Tea: a double edged sword that induces tumor cell apoptosis and ameliorates
immunosuppression of tumor-bearer. Deba Prasad Mandal, Arindam Bhattacharyya,
Lakshmisri Lahiri, Sankar Bhattacharyya, Uttam Ghosh, Tanya Das. nternational
Symposium on Diet in causation and Prevention of Cancer and XXX Annual Conference
of Environmental Mutagen Society of India, March 2005.
UGC Sponsored State Level Seminar on Conservation of Biodiversity: Assessment &
Awareness Organized by Dept. of Zoology, Hooghly Mohsin College in collaboration
with Dept. of Zoology, West Bengal State University. October 2011.
International Workshop on Application of Flowcytometry and Imaging Cell Biology and
Nanobiotechnology 2012. 11-18th August. Centre for Nanoscience and Nanotechnology
(CRNN), University of Calcutta, Kolkata, India.
INVITED TALK
Antitumorigenic potential of linalool: a spice principle with a promise Jana S, Patra K, Sarkar S, Jana
J, Mukherjee G, Bhattacharjee S, Mandal DP. PHYSICON 2014, 19 - 21st December, 2014,
Berhampore, Murshidabad, West Bengal.
RESEARCH PROJECTS
Ongoing Projects
Sl. Title of Project
No.
PI/CoPI Funding
Agency
Amount
Date of
sanction
and
Duration
February
2012
1
An Investigation into the
Co-PI
Regulation of Nrf2 transcription
factor by diosgenin and 1,8cineole using the p53/p21 axis
in lung and leukaemic cancer.
Letter No. 5/13/49/10/NCD-III,
dated 30-05 -2011
Indian Council
of Medical
Research,
Govt. of India.
Rs 23
lacs
approx
2
Overcoming EGFR resistant
Oral Squamous Cell
Carcinomas with traditional
healers of Tripura – A
Preclinical Study”
PI
DBT-NER,
Govt. of India
(Twinning
Programme
2013-14)
32.9
lakhs
(20142017)
March
2014
PI/CoPI
Funding
Agency
Amount
Date of
completion
Completed Projects
Sl.
No.
Title of Project
1
2
Investigation
into
the
PI
modulation of TGF signaling
by capsaicin and eugenol using
the p53/p21 axis in gastric
carcinoma.
BT/PR15116/GBD/27/327/2011
dated 09/03/2011
Modulation of tumor
Co-PI
angiogenesis by the use of
active ingredients of Pimpenella
anisum and Coriandrum
sativum in mice, a preclinical
study.
Sanction No. Ref No.
37(1487)/1 1/EMR-II
Department of
Biotechnology,
Govt. of India
37 lacs
approx
March 2014
CSIR, Govt. of
India
Rs 20
lacs
approx
May 2014
LIST OF COLLABORATORS
Dr. Shamee Bhattacharjee, Department of Zoology, West Bengal State University
Dr. Subhragshu Chatterjree, Department of Biophysics, Bose Institute.
Dr. Utpal De , Department of Chemistry, Tripura University
Dr. Gopeswar Mukherjee, Department of Pathology, Barasat District Hospital.
Dr. Anirban Bhunia, Department of Biophysics, Bose Institute.
Dr. Mridu Gupta, Department Dravyaguna (Medicinal plant Pharmacology), Institute of Post
Graduate Ayurvedic Education and Research.
PERSONAL DATA
th
DATE OF BIRTH: 6 September, 1972
PLACE OF BIRTH: India
LANGUAGES: Bengali, English