Download this supplementary material

GIANTConsortium2010,Speliotesetal.
ElizabethKSpeliotes1,2,CristenJWiller3,SonjaIBerndt4KeriLMonda5,Gudmar
Thorleifsson6,AnneUJackson3,HanaLangoAllen7,CeciliaMLindgren8,9,Jian’anLuan10,
ReedikMägi8,JoshuaCRandall8,SailajaVedantam1,11,ThomasWWinkler12,LuQi13,14,
TsegaselassieWorkalemahu13,IrisMHeid12,15,ValgerdurSteinthorsdottir6,HeatherM
Stringham3,MichaelNWeedon7,EleanorWheeler16,AndrewRWood7,TeresaFerreira8,
RobertJWeyant3,AyelletVSegrè17–19,KarolEstrada20–22,LimingLiang23,24,James
Nemesh18,Ju-HyunPark4,StefanGustafsson25,TuomasOKilpeläinen10,JianYang26,
NabilaBouatia-Naji27,28,TõnuEsko29–31,MaryFFeitosa32,ZoltánKutalik33,34,Massimo
Mangino35,SoumyaRaychaudhuri18,36,AndreScherag37,AlbertVernonSmith38,39,Ryan
Welch3,JingHuaZhao10,KatjaKAben40,DevinMAbsher41,NajafAmin20,AnnaLDixon42,
EvaFisher43,NicoleLGlazer44,45,MichaelEGoddard46,47,NancyLHeard-Costa48,Volker
Hoesel49,Jouke-JanHottenga50,ÅsaJohansson51,52,TobyJohnson33,34,53,54,Shamika
Ketkar32,ClaudiaLamina15,55,ShengxuLi10,MiriamFMoffatt56,RichardHMyers57,
NarisuNarisu58,JohnRBPerry7,MarjoleinJPeters21,22,MichaelPreuss59,Samuli
Ripatti60,61,FernandoRivadeneira20–22,CamillaSandholt62,LauraJScott3,NicholasJ
Timpson63,JonathanPTyrer64,SophievanWingerden20,RichardMWatanabe65,66,
CharlesCWhite67,FredrikWiklund25,ChristinaBarlassina68,DanielIChasman69,70,
MatthewNCooper71,John-OlovJansson72,RobertWLawrence71,NiinaPellikka60,61,Inga
Prokopenko8,9,JianxinShi4,ElisabethThiering15,HeleneAlavere29,MariaTSAlibrandi73,
PeterAlmgren74,AliceMArnold75,76,ThorAspelund38,39,LarryDAtwood48,Beverley
Balkau77,78,AnthonyJBalmforth79,AmandaJBennett9,YoavBen-Shlomo80,RichardN
Bergman66,SvenBergmann33,34,HeikeBiebermann81,AlexandraIFBlakemore82,Tanja
Boes37,LoriLBonnycastle58,StefanRBornstein83,MorrisJBrown84,ThomasA
Buchanan66,85,FabioBusonero86,HarryCampbell87,FrancescoPCappuccio88,Christine
Cavalcanti-Proença27,28,Yii-DerIdaChen89,Chih-MeiChen15,PeterSChines58,Robert
Clarke90,LachlanCoin91,JohnConnell92,IanNMDay63,MartindenHeijer93,94,Jubao
Duan95,ShahEbrahim96,97,PaulElliott91,98,RobertoElosua99,GudnyEiriksdottir38,
MichaelRErdos58,JohanGEriksson100–104,MaurizioFFacheris105,106,StephanBFelix107,
PamelaFischer-Posovszky108,AaronRFolsom109,NeleFriedrich110,NelsonBFreimer111,
MaoFu112,StefanGaget27,28,PabloVGejman95,EcoJCGeus50,ChristianGieger15,AnetteP
Gjesing62,AnujGoel8,113,PhilippeGoyette114,HaraldGrallert15,JürgenGräßler115,
DanielleMGreenawalt116,ChristopherJGroves9,VilmundurGudnason38,39,Candace
Guiducci1,Anna-LiisaHartikainen117,NeelamHassanali9,AlistairSHall79,Aki
SHavulinna118,CarolineHayward119,AndrewCHeath120,ChristianHengstenberg121,122,
AndrewAHicks105,AnkeHinney123,AlbertHofman20,22,GeorgHomuth124,Jennie
Hui71,125,126,WilmarIgl51,CarlosIribarren127,128,BoIsomaa103,129,KevinBJacobs130,
IvonneJarick131,ElizabethJewell3,UlrichJohn132,TorbenJørgensen133,134,Pekka
Jousilahti118,AnttiJula135,MarikaKaakinen136,137,EeroKajantie101,138,LeeMKaplan2,70,139,
SekarKathiresan17,18,140–142,JohannesKettunen60,61,LeenaKinnunen143,JoshuaW
Knowles144,IvanaKolcic145,InkeRKönig59,SeppoKoskinen118,PeterKovacs146,Johanna
Kuusisto147,PeterKraft23,24,KirstiKvaløy148,JaanaLaitinen149,OlivierLantieri150,Chiara
Lanzani73,LenoreJLauner151,CecileLecoeur27,28,TerhoLehtimäki152,Guillaume
Lettre114,153,JianjunLiu154,Marja-LiisaLokki155,MattiasLorentzon156,RobertNLuben157,
BarbaraLudwig83,MAGIC158,PaoloManunta73,DianaMarek33,34,MichelMarre159,160,
NicholasGMartin161,WendyLMcArdle162,AnneMcCarthy163,BarbaraMcKnight75,
ThomasMeitinger164,165,OlleMelander166,DavidMeyre27,28,KristianMidthjell148,Grant
WMontgomery167,MarioAMorken58,AndrewPMorris8,RosandaMulic168,JuliusS
Ngwa67,MariNelis29–31,MattJNeville9,DaleRNyholt169,ChristopherJO’Donnell141,170,
StephenO’Rahilly171,KenKOng10,BenOostra172,GuillaumeParé173,AlexNParker174,
MarkusPerola60,61,IrenePichler105,KirsiHPietiläinen175,176,CarlGPPlatou148,177,Ozren
Polasek145,178,AnneliPouta117,179,SuzanneRafelt180,OlliRaitakari181,182,NigelW
Rayner8,9,MartinRidderstråle166,WinfriedRief183,AimoRuokonen184,NeilR
Robertson8,9,PeterRzehak15,185,VeikkoSalomaa118,AlanRSanders95,ManjinderS
Sandhu10,16,157,SerenaSanna86,JoukoSaramies186,MarkkuJSavolainen187,Susann
Scherag123,SabineSchipf110,188,StefanSchreiber189,HeribertSchunkert190,Kaisa
Silander60,61,JuhaSinisalo191,DavidSSiscovick45,192,JanHSmit193,NicoleSoranzo16,35,
UllaSovio91,JonathanStephens194,195,IdaSurakka60,61,AmyJSwift58,Mari-Liis
Tammesoo29,Jean-ClaudeTardif114,153,MarisTeder-Laving30,31,TanyaMTeslovich3,John
RThompson196,197,BrianThomson1,AnkeTönjes198,199,TiinamaijaTuomi103,200,201,Joyce
BJvanMeurs20–22,Gert-JanvanOmmen202,203,VincentVatin27,28,JormaViikari204,Sophie
Visvikis-Siest205,VeroniqueVitart119,CarlaIGVogel123,BenjaminFVoight17–19,Lindsay
LWaite41,HenriWallaschofski110,GBragiWalters6,ElisabethWiden60,Susanna
Wiegand81,SarahHWild87,GonnekeWillemsen50,DanielRWitte206,Jacqueline
CWitteman20,22,JianfengXu207,QunyuanZhang32,LinaZgaga145,AndreasZiegler59,Paavo
Zitting208,JohnPBeilby125,126,209,ISadafFarooqi171,JohannesHebebrand123,HeikkiV
Huikuri210,AlanLJames126,211,MikaKähönen212,DouglasFLevinson213,Fabio
Macciardi68,214,MarkkuSNieminen191,ClaesOhlsson156,LyleJPalmer71,126,Paul
MRidker69,70,MichaelStumvoll198,215,JacquesSBeckmann33,216,HeinerBoeing43,Eric
Boerwinkle217,DorretIBoomsma50,MarkJCaulfield54,StephenJChanock4,FrancisS
Collins58,LAdrienneCupples67,GeorgeDaveySmith63,JeanetteErdmann190,Philippe
Froguel27,28,82,HenrikGrönberg25,UlfGyllensten51,PerHall25,TorbenHansen62,218,
TamaraBHarris151,AndrewTHattersley7,RichardBHayes219,JoachimHeinrich15,Frank
BHu13,14,23,KristianHveem148,ThomasIllig15,Marjo-RiittaJarvelin91,136,137,179,Jaakko
Kaprio60,175,220,FredrikKarpe9,221,Kay-TeeKhaw157,LambertusAKiemeney40,93,222,Heiko
Krude81,MarkkuLaakso147,DebbieALawlor63,AndresMetspalu29–31,PatriciaB
Munroe54,WillemHOuwehand16,194,195,OlufPedersen62,223,224,BrendaWPenninx193,225,226,
AnnettePeters15,PeterPPramstaller105,106,227,ThomasQuertermous144,Thomas
Reinehr228,AilaRissanen176,IgorRudan87,168,NileshJSamani180,196,PeterEHSchwarz229,
AlanRShuldiner112,230,TimothyDSpector35,JaakkoTuomilehto143,231,232,ManuelaUda86,
AndréUitterlinden20–22,TimoTValle143,MartinWabitsch108,GérardWaeber233,Nicholas
JWareham10,HughWatkins8,113,onbehalfofProcardisConsortium,JamesFWilson87,
AlanFWright119,MCarolaZillikens21,22,NilanjanChatterjee4,StevenAMcCarroll17–19,
ShaunPurcell17,234,235,EricESchadt236,237,PeterMVisscher26,ThemistoclesLAssimes144,
IngridBBorecki32,238,PanosDeloukas16,CarolineSFox239,LeifCGroop74,Talin
Haritunians89,DavidJHunter13,14,23,RobertCKaplan240,KarenLMohlke241,JeffreyR
O’Connell112,LeenaPeltonen16,60,61,234,242,DavidSchlessinger243,DavidPStrachan244,
CorneliaMvanDuijn20,22,H-ErichWichmann15,185,245,TimothyMFrayling7,Unnur
Thorsteinsdottir6,246,GonçaloRAbecasis3,InêsBarroso16,247,MichaelBoehnke3,Kari
Stefansson6,246,KariENorth5,248,MarkIMcCarthy8,9,221,JoelNHirschhorn1,11,249,Erik
Ingelsson25&RuthJFLoos10
1MetabolismInitiativeandPrograminMedicalandPopulationGenetics,BroadInstitute,
Cambridge,Massachusetts,USA.2DivisionofGastroenterology,MassachusettsGeneralHospital,
Boston,Massachusetts,USA.3DepartmentofBiostatistics,CenterforStatisticalGenetics,
UniversityofMichigan,AnnArbor,Michigan,USA.4DivisionofCancerEpidemiologyand
Genetics,NationalCancerInstitute,NationalInstitutesofHealth,DepartmentofHealthand
HumanServices,Bethesda,Maryland,USA.5DepartmentofEpidemiology,SchoolofPublic
Health,UniversityofNorthCarolinaatChapelHill,ChapelHill,NorthCarolina,USA.6deCODE
Genetics,Reykjavik,Iceland.7GeneticsofComplexTraits,PeninsulaCollegeofMedicineand
Dentistry,UniversityofExeter,Exeter,UK.8WellcomeTrustCentreforHumanGenetics,
UniversityofOxford,Oxford,UK.9OxfordCentreforDiabetes,EndocrinologyandMetabolism,
UniversityofOxford,Oxford,UK.10MedicalResearchCouncil(MRC)EpidemiologyUnit,Institute
ofMetabolicScience,Addenbrooke’sHospital,Cambridge,UK.11DivisionsofGeneticsand
EndocrinologyandPrograminGenomics,Children’sHospital,Boston,Massachusetts,USA.
12RegensburgUniversityMedicalCenter,DepartmentofEpidemiologyandPreventiveMedicine,
Regensburg,Germany.13DepartmentofNutrition,HarvardSchoolofPublicHealth,Boston,
Massachusetts,USA.14ChanningLaboratory,DepartmentofMedicine,BrighamandWomen’s
HospitalandHarvardMedicalSchool,Boston,Massachusetts,USA.15InstituteofEpidemiology,
HelmholtzZentrumMünchen-GermanResearchCenterforEnvironmentalHealth,Neuherberg,
Germany.16WellcomeTrustSangerInstitute,Hinxton,Cambridge,UK.17CenterforHuman
GeneticResearch,MassachusettsGeneralHospital,Boston,Massachusetts,USA.18Programin
MedicalandPopulationGenetics,BroadInstituteofHarvardandMassachusettsInstituteof
Technology,Cambridge,Massachusetts,USA.19DepartmentofMolecularBiology,Massachusetts
GeneralHospital,Boston,Massachusetts,USA.20DepartmentofEpidemiology,ErasmusMedical
Center(MC),Rotterdam,TheNetherlands.21DepartmentofInternalMedicine,ErasmusMC,
Rotterdam,TheNetherlands.22NetherlandsGenomicsInitiative(NGI)-sponsoredNetherlands
ConsortiumforHealthyAging(NCHA),Rotterdam,TheNetherlands.23Departmentof
Epidemiology,HarvardSchoolofPublicHealth,Boston,Massachusetts,USA.24Departmentof
Biostatistics,HarvardSchoolofPublicHealth,Boston,Massachusetts,USA.25Departmentof
MedicalEpidemiologyandBiostatistics,KarolinskaInstitutet,Stockholm,Sweden.26Queensland
StatisticalGeneticsLaboratory,QueenslandInstituteofMedicalResearch,Queensland,Australia.
27CentreNationaldelaRechercheScientifique(CNRS)UMR8199-IBL-InstitutPasteurdeLille,
Lille,France.28UniversityLilleNorddeFrance,Lille,France.29EstonianGenomeCenter,
UniversityofTartu,Tartu,Estonia.30EstonianBiocenter,Tartu,Estonia.31InstituteofMolecular
andCellBiology,UniversityofTartu,Tartu,Estonia.32DepartmentofGenetics,Washington
UniversitySchoolofMedicine,St.Louis,Missouri,USA.33DepartmentofMedicalGenetics,
UniversityofLausanne,Lausanne,Switzerland.34SwissInstituteofBioinformatics,Lausanne,
Switzerland.35DepartmentofTwinResearchandGeneticEpidemiology,King’sCollegeLondon,
London,UK.36DivisionofRheumatology,ImmunologyandAllergy,BrighamandWomen’s
Hospital,HarvardMedicalSchool,Boston,Massachusetts,USA.37InstituteforMedical
Informatics,BiometryandEpidemiology,UniversityofDuisburg-Essen,Essen,Germany.
38IcelandicHeartAssociation,Kopavogur,Iceland.39UniversityofIceland,Reykjavik,Iceland.
40ComprehensiveCancerCenterEast,Nijmegen,TheNetherlands.41HudsonAlphaInstitutefor
Biotechnology,Huntsville,Alabama,USA.42DepartmentofPharmacyandPharmacology,
UniversityofBath,Bath,UK.43DepartmentofEpidemiology,GermanInstituteofHuman
NutritionPotsdam-Rehbruecke,Nuthetal,Germany.44DepartmentofMedicine,Universityof
Washington,Seattle,Washington,USA.45CardiovascularHealthResearchUnit,Universityof
Washington,Seattle,Washington,USA.46UniversityofMelbourne,Parkville,Australia.
47DepartmentofPrimaryIndustries,Melbourne,Victoria,Australia.48DepartmentofNeurology,
BostonUniversitySchoolofMedicine,Boston,Massachusetts,USA.49TechnicalUniversity
Munich,ChairofBiomathematics,Garching,Germany.50DepartmentofBiologicalPsychology,
VrijeUniversiteit(VU)UniversityAmsterdam,Amsterdam,TheNetherlands.51Departmentof
GeneticsandPathology,RudbeckLaboratory,UniversityofUppsala,Uppsala,Sweden.
52DepartmentofCancerResearchandMolecularMedicine,FacultyofMedicine,Norwegian
UniversityofScienceandTechnology(NTNU),Trondheim,Norway.53ClinicalPharmacology,
WilliamHarveyResearchInstitute,BartsandTheLondonSchoolofMedicineandDentistry,
QueenMary,UniversityofLondon,London,UK.54ClinicalPharmacologyandBartsandThe
LondonGenomeCentre,WilliamHarveyResearchInstitute,BartsandTheLondonSchoolof
MedicineandDentistry,QueenMaryUniversityofLondon,CharterhouseSquare,London,UK.
55DivisionofGeneticEpidemiology,DepartmentofMedicalGenetics,MolecularandClinical
Pharmacology,InnsbruckMedicalUniversity,Innsbruck,Austria.56NationalHeartandLung
Institute,ImperialCollegeLondon,London,UK.57DepartmentofNeurology,BostonUniversity
SchoolofMedicine,Boston,Massachusetts,USA.58NationalHumanGenomeResearchInstitute,
NationalInstitutesofHealth,Bethesda,Maryland,USA.59InstitutfürMedizinischeBiometrieund
Statistik,UniversitätzuLübeck,UniversitätsklinikumSchleswig-Holstein,CampusLübeck,
Lübeck,Germany.60InstituteforMolecularMedicineFinland(FIMM),UniversityofHelsinki,
Helsinki,Finland.61NationalInstituteforHealthandWelfare,DepartmentofChronicDisease
Prevention,UnitofPublicHealthGenomics,Helsinki,Finland.62HagedornResearchInstitute,
Gentofte,Denmark.63MRCCentreforCausalAnalysesinTranslationalEpidemiology,Department
ofSocialMedicine,OakfieldHouse,Bristol,UK.64DepartmentofOncology,Universityof
Cambridge,Cambridge,UK.65DepartmentofPreventiveMedicine,KeckSchoolofMedicine,
UniversityofSouthernCalifornia,LosAngeles,California,USA.66DepartmentofPhysiologyand
Biophysics,KeckSchoolofMedicine,UniversityofSouthernCalifornia,LosAngeles,California,
USA.67DepartmentofBiostatistics,BostonUniversitySchoolofPublicHealth,Boston,
Massachusetts,USA.68UniversityofMilan,DepartmentofMedicine,SurgeryandDentistry,
Milano,Italy.69DivisionofPreventiveMedicine,BrighamandWomen’sHospital,Boston,
Massachusetts,USA.70HarvardMedicalSchool,Boston,Massachusetts,USA.71CentreforGenetic
EpidemiologyandBiostatistics,UniversityofWesternAustralia,Crawley,WesternAustralia,
Australia.72DepartmentofPhysiology,InstituteofNeuroscienceandPhysiology,Sahlgrenska
Academy,UniversityofGothenburg,Gothenburg,Sweden.73UniversityVita-SaluteSanRaffaele,
DivisionofNephrologyandDialysis,Milan,Italy.74LundUniversityDiabetesCentre,Department
ofClinicalSciences,LundUniversity,Malmö,Sweden.75DepartmentofBiostatistics,Universityof
Washington,Seattle,Washington,USA.76CollaborativeHealthStudiesCoordinatingCenter,
Seattle,Washington,USA.77INSERMCentrederechercheenEpidémiologieetSantédes
Populations(CESP)CentreforResearchinEpidemiologyandPublicHealthU1018,Villejuif,
France.78UniversityParisSud11,UnitéMixtedeRechercheenSanté(UMRS)1018,Villejuif,
France.79MultidisciplinaryCardiovascularResearchCentre(MCRC),LeedsInstituteofGenetics,
HealthandTherapeutics(LIGHT),UniversityofLeeds,Leeds,UK.80DepartmentofSocial
Medicine,UniversityofBristol,Bristol,UK.81InstituteofExperimentalPaediatricEndocrinology,
CharitéUniversitätsmedizinBerlin,Berlin,Germany.82DepartmentofGenomicsofCommon
Disease,SchoolofPublicHealth,ImperialCollegeLondon,London,UK.83DepartmentofMedicine
III,UniversityofDresden,Dresden,Germany.84ClinicalPharmacologyUnit,Universityof
Cambridge,Addenbrooke’sHospital,Cambridge,UK.85DivisionofEndocrinology,KeckSchoolof
Medicine,UniversityofSouthernCalifornia,LosAngeles,California,USA.86Istitutodi
NeurogeneticaeNeurofarmacologiadelConsiglioNazionaledelleRicerche(CNR),Monserrato,
Cagliari,Italy.87CentreforPopulationHealthSciences,UniversityofEdinburgh,TeviotPlace,
Edinburgh,Scotland,UK.88UniversityofWarwick,WarwickMedicalSchool,Coventry,UK.
89MedicalGeneticsInstitute,Cedars-SinaiMedicalCenter,LosAngeles,California,USA.90Clinical
TrialServiceUnit,Oxford,UK.91DepartmentofEpidemiologyandBiostatistics,SchoolofPublic
Health,FacultyofMedicine,ImperialCollegeLondon,London,UK.92UniversityofDundee,
NinewellsHospitalandMedicalSchool,Dundee,UK.93DepartmentofEpidemiology,Biostatistics
andHTA,RadboudUniversityNijmegenMedicalCentre,Nijmegen,TheNetherlands.
94DepartmentofEndocrinology,RadboudUniversityNijmegenMedicalCentre,Nijmegen,The
Netherlands.95NorthshoreUniversityHealthsystem,Evanston,Illinois,USA.96TheLondonSchool
ofHygieneandTropicalMedicine,London,UK.97SouthAsiaNetworkforChronicDisease,New
Dehli,India.98MRC-HealthProtectionAgency(HPA)CentreforEnvironmentandHealth,London,
UK.99CardiovascularEpidemiologyandGenetics,InstitutMunicipalD’investigacioMedicaand
CentrodeInvestigaciónBiomédicaenRedCIBEREpidemiologíaySaludPública,Barcelona,
Spain.100DepartmentofGeneralPracticeandPrimaryHealthCare,UniversityofHelsinki,
Helsinki,Finland.101NationalInstituteforHealthandWelfare,Helsinki,Finland.102Helsinki
UniversityCentralHospital,UnitofGeneralPractice,Helsinki,Finland.103FolkhalsanResearch
Centre,Helsinki,Finland.104VasaCentralHospital,Vasa,Finland.105InstituteofGeneticMedicine,
EuropeanAcademyBozen-Bolzano(EURAC),Bolzano-Bozen,Italy,AffiliatedInstituteofthe
UniversityofLübeck,Lübeck,Germany.106DepartmentofNeurology,GeneralCentralHospital,
Bolzano,Italy.107DepartmentofInternalMedicineB,Ernst-Moritz-ArndtUniversity,Greifswald,
Germany.108PediatricEndocrinology,DiabetesandObesityUnit,DepartmentofPediatricsand
AdolescentMedicine,Ulm,Germany.109DivisionofEpidemiologyandCommunityHealth,School
ofPublicHealth,UniversityofMinnesota,Minneapolis,Minnesota,USA.110InstitutfürKlinische
ChemieundLaboratoriumsmedizin,UniversitätGreifswald,Greifswald,Germany.111Centerfor
NeurobehavioralGenetics,UniversityofCalifornia,LosAngeles,California,USA.112Departmentof
Medicine,UniversityofMarylandSchoolofMedicine,Baltimore,Maryland,USA.113Departmentof
CardiovascularMedicine,UniversityofOxford,JohnRadcliffeHospital,Headington,Oxford,UK.
114MontrealHeartInstitute,Montreal,Quebec,Canada.115DepartmentofMedicineIII,
Pathobiochemistry,UniversityofDresden,Dresden,Germany.116MerckResearchLaboratories,
MerckandCo.,Inc.,Boston,Massachusetts,USA.117DepartmentofClinicalSciences,Obstetrics
andGynecology,UniversityofOulu,Oulu,Finland.118NationalInstituteforHealthandWelfare,
DepartmentofChronicDiseasePrevention,ChronicDiseaseEpidemiologyandPreventionUnit,
Helsinki,Finland.119MRCHumanGeneticsUnit,InstituteforGeneticsandMolecularMedicine,
WesternGeneralHospital,Edinburgh,Scotland,UK.120DepartmentofPsychiatryandMidwest
AlcoholismResearchCenter,WashingtonUniversitySchoolofMedicine,St.Louis,Missouri,USA.
121KlinikundPoliklinikfürInnereMedizinII,UniversitätRegensburg,Regensburg,Germany.
122RegensburgUniversityMedicalCenter,InnereMedizinII,Regensburg,Germany.
123DepartmentofChildandAdolescentPsychiatry,UniversityofDuisburg-Essen,Essen,
Germany.124InterfacultyInstituteforGeneticsandFunctionalGenomics,Ernst-Moritz-Arndt-
UniversityGreifswald,Greifswald,Germany.125PathWestLaboratoryofWesternAustralia,
DepartmentofMolecularGenetics,JBlock,QEIIMedicalCentre,Nedlands,WesternAustralia,
Australia.126BusseltonPopulationMedicalResearchFoundationInc.,SirCharlesGairdner
Hospital,Nedlands,WesternAustralia,Australia.127DivisionofResearch,KaiserPermanente
NorthernCalifornia,Oakland,California,USA.128DepartmentofEpidemiologyandBiostatistics,
UniversityofCalifornia,SanFrancisco,SanFrancisco,California,USA.129DepartmentofSocial
ServicesandHealthCare,Jakobstad,Finland.130CoreGenotypingFacility,SAIC-Frederick,Inc.,
NationalCancerInstitute(NCI)-Frederick,Frederick,Maryland,USA.131InstituteofMedical
BiometryandEpidemiology,UniversityofMarburg,Marburg,Germany.132Institutfür
EpidemiologieundSozialmedizin,UniversitätGreifswald,Greifswald,Germany.133Research
CentreforPreventionandHealth,GlostrupUniversityHospital,Glostrup,Denmark.134Facultyof
HealthScience,UniversityofCopenhagen,Copenhagen,Denmark.135NationalInstituteforHealth
andWelfare,DepartmentofChronicDiseasePrevention,PopulationStudiesUnit,Turku,Finland.
136InstituteofHealthSciences,UniversityofOulu,Oulu,Finland.137BiocenterOulu,Universityof
Oulu,Oulu,Finland.138HospitalforChildrenandAdolescents,HelsinkiUniversityCentral
HospitalandUniversityofHelsinki,HospitalDistrictofHelsinkiandUusimaa(HUS),Helsinki,
Finland.139MassachusettsGeneralHospital(MGH)WeightCenter,MassachusettsGeneral
Hospital,Boston,Massachusetts,USA.140CardiovascularResearchCenterandCardiology
Division,MassachusettsGeneralHospital,Boston,Massachusetts,USA.141FraminghamHeart
StudyoftheNational,Heart,Lung,andBloodInstituteandBostonUniversity,Framingham,
Massachusetts,USA.142DepartmentofMedicine,HarvardMedicalSchool,Boston,Massachusetts,
USA.143NationalInstituteforHealthandWelfare,DiabetesPreventionUnit,Helsinki,Finland.
144DepartmentofMedicine,StanfordUniversitySchoolofMedicine,Stanford,California,USA.
145AndrijaStamparSchoolofPublicHealth,MedicalSchool,UniversityofZagreb,Zagreb,Croatia.
146InterdisciplinaryCentreforClinicalResearch,UniversityofLeipzig,Leipzig,Germany.
147DepartmentofMedicine,UniversityofKuopioandKuopioUniversityHospital,Kuopio,
Finland.148Nord-TrøndelagHealthStudy(HUNT)ResearchCentre,DepartmentofPublicHealth
andGeneralPractice,NorwegianUniversityofScienceandTechnology,Levanger,Norway.
149FinnishInstituteofOccupationalHealth,Oulu,Finland.150Institutinter-regionalpourlasanté
(IRSA),LaRiche,France.151LaboratoryofEpidemiology,Demography,Biometry,National
InstituteonAging,NationalInstitutesofHealth,Bethesda,Maryland,USA.152Departmentof
ClinicalChemistry,UniversityofTampereandTampereUniversityHospital,Tampere,Finland.
153DepartmentofMedicine,UniversitédeMontréal,Montreal,Quebec,Canada.154Human
Genetics,GenomeInstituteofSingapore,Singapore,Singapore.155TransplantationLaboratory,
HaartmanInstitute,UniversityofHelsinki,Helsinki,Finland.156DepartmentofInternalMedicine,
InstituteofMedicine,SahlgrenskaAcademy,UniversityofGothenburg,Gothenburg,Sweden.
157DepartmentofPublicHealthandPrimaryCare,InstituteofPublicHealth,Universityof
Cambridge,Cambridge,UK.158OnbehalfoftheMAGIC(Meta-AnalysesofGlucoseandInsulinRelatedTraitsConsortium)investigators.159DepartmentofEndocrinology,Diabetologyand
Nutrition,Bichat-ClaudeBernardUniversityHospital,AssistancePubliquedesHôpitauxdeParis,
Paris,France.160CardiovascularGeneticsResearchUnit,UniversitéHenriPoincaré-Nancy1,
Nancy,France.161GeneticEpidemiologyLaboratory,QueenslandInstituteofMedicalResearch,
Queensland,Australia.162AvonLongitudinalStudyofParentsandChildren(ALSPAC)Laboratory,
DepartmentofSocialMedicine,UniversityofBristol,Bristol,UK.163DivisionofHealth,Research
Board,AnBordTaighdeSláinte,Dublin,Ireland.164InstituteofHumanGenetics,Klinikumrechts
derIsarderTechnischenUniversitätMünchen,Munich,Germany.165InstituteofHumanGenetics,
HelmholtzZentrumMünchen-GermanResearchCenterforEnvironmentalHealth,Neuherberg,
Germany.166DepartmentofClinicalSciences,LundUniversity,Malmö,Sweden.167Molecular
EpidemiologyLaboratory,QueenslandInstituteofMedicalResearch,Queensland,Australia.
168CroatianCentreforGlobalHealth,SchoolofMedicine,UniversityofSplit,Split,Croatia.
169NeurogeneticsLaboratory,QueenslandInstituteofMedicalResearch,Queensland,Australia.
170NationalHeart,Lung,andBloodInstitute,NationalInstitutesofHealth,Framingham,
Massachusetts,USA.171UniversityofCambridgeMetabolicResearchLaboratories,Instituteof
MetabolicScience,Addenbrooke’sHospital,Cambridge,UK.172DepartmentofClinicalGenetics,
ErasmusMC,Rotterdam,TheNetherlands.173DepartmentofPathologyandMolecularMedicine,
McMasterUniversity,Hamilton,Ontario,Canada.174Amgen,Cambridge,Massachusetts,USA.
175FinnishTwinCohortStudy,DepartmentofPublicHealth,UniversityofHelsinki,Helsinki,
Finland.176ObesityResearchUnit,DepartmentofPsychiatry,HelsinkiUniversityCentralHospital,
Helsinki,Finland.177DepartmentofMedicine,LevangerHospital,TheNord-TrøndelagHealth
Trust,Levanger,Norway.178Gen-InfoLtd,Zagreb,Croatia.179NationalInstituteforHealthand
Welfare,Oulu,Finland.180DepartmentofCardiovascularSciences,UniversityofLeicester,
GlenfieldHospital,Leicester,UK.181ResearchCentreofAppliedandPreventiveCardiovascular
Medicine,UniversityofTurku,Turku,Finland.182TheDepartmentofClinicalPhysiology,Turku
UniversityHospital,Turku,Finland.183ClinicalPsychologyandPsychotherapy,Universityof
Marburg,Marburg,Germany.184DepartmentofClinicalSciencesandClinicalChemistry,
UniversityofOulu,Oulu,Finland.185Ludwig-Maximilians-Universität,InstituteofMedical
Informatics,BiometryandEpidemiology,ChairofEpidemiology,Munich,Germany.186South
KareliaCentralHospital,Lappeenranta,Finland.187DepartmentofClinicalSciencesandInternal
Medicine,UniversityofOulu,Oulu,Finland.188InstitutfürCommunityMedicine,Greifswald,
Germany.189Christian-Albrechts-University,UniversityHospitalSchleswig-Holstein,Institutefor
ClinicalMolecularBiologyandDepartmentofInternalMedicineI,Kiel,Germany.190Universität
zuLübeck,MedizinischeKlinikII,Lübeck,Germany.191DivisionofCardiology,Cardiovascular
Laboratory,HelsinkiUniversityCentralHospital,Helsinki,Finland.192DepartmentsofMedicine
andEpidemiology,UniversityofWashington,Seattle,Washington,USA.193Departmentof
Psychiatry,InstituutvoorExtramuraalGeneeskundigOnderzoek(EMGO)Institute,VUUniversity
MedicalCenter,Amsterdam,TheNetherlands.194DepartmentofHaematology,Universityof
Cambridge,Cambridge,UK.195NationalHealthService(NHS)BloodandTransplant,Cambridge
Centre,Cambridge,UK.196LeicesterNIHRBiomedicalResearchUnitinCardiovascularDisease,
GlenfieldHospital,Leicester,UK.197DepartmentofHealthSciences,UniversityofLeicester,
UniversityRoad,Leicester,UK.198DepartmentofMedicine,UniversityofLeipzig,Leipzig,
Germany.199CoordinationCentreforClinicalTrials,UniversityofLeipzig,Leipzig,Germany.
200DepartmentofMedicine,HelsinkiUniversityCentralHospital,Helsinki,Finland.201Research
ProgramofMolecularMedicine,UniversityofHelsinki,Helsinki,Finland.202Departmentof
HumanGenetics,LeidenUniversityMedicalCenter,Leiden,TheNetherlands.203CenterofMedical
SystemsBiology,LeidenUniversityMedicalCenter,Leiden,TheNetherlands.204Departmentof
Medicine,UniversityofTurkuandTurkuUniversityHospital,Turku,Finland.205INSERM
CardiovascularGeneticsteam,CentreInvestigationClinique(CIC)9501,Nancy,France.206Steno
DiabetesCenter,Gentofte,Denmark.207CenterforHumanGenomics,WakeForestUniversity,
Winston-Salem,NorthCarolina,USA.208DepartmentofPhysiatrics,LaplandCentralHospital,
Rovaniemi,Finland.209SchoolofPathologyandLaboratoryMedicine,UniversityofWestern
Australia,Nedlands,WesternAustralia,Australia.210DepartmentofInternalMedicine,University
ofOulu,Oulu,Finland.211SchoolofMedicineandPharmacology,UniversityofWesternAustralia,
Perth,WesternAustralia,Australia.212DepartmentofClinicalPhysiology,UniversityofTampere
andTampereUniversityHospital,Tampere,Finland.213StanfordUniversitySchoolofMedicine,
Stanford,California,USA.214DepartmentofPsychiatryandHumanBehavior,Universityof
California,Irvine(UCI),Irvine,California,USA.215LeipzigerInterdisziplinärerForschungskomplexzumolekularenUrsachenumwelt-undlebensstilassoziierterErkrankungen(LIFE)
StudyCentre,UniversityofLeipzig,Leipzig,Germany.216ServiceofMedicalGenetics,Centre
HospitalierUniversitaireVaudois(CHUV)UniversityHospital,Lausanne,Switzerland.217Human
GeneticsCenterandInstituteofMolecularMedicine,UniversityofTexasHealthScienceCenter,
Houston,Texas,USA.218FacultyofHealthScience,UniversityofSouthernDenmark,Odense,
Denmark.219NewYorkUniversityMedicalCenter,NewYork,NewYork,USA.220NationalInstitute
forHealthandWelfare,DepartmentofMentalHealthandSubstanceAbuseServices,Unitfor
ChildandAdolescentMentalHealth,Helsinki,Finland.221NIHROxfordBiomedicalResearch
Centre,ChurchillHospital,Oxford,UK.222DepartmentofUrology,RadboudUniversityNijmegen
MedicalCentre,Nijmegen,TheNetherlands.223InstituteofBiomedicalSciences,Universityof
Copenhagen,Copenhagen,Denmark.224FacultyofHealthScience,UniversityofAarhus,Aarhus,
Denmark.225DepartmentofPsychiatry,LeidenUniversityMedicalCentre,Leiden,The
Netherlands.226DepartmentofPsychiatry,UniversityMedicalCentreGroningen,Groningen,The
Netherlands.227DepartmentofNeurology,UniversityofLübeck,Lübeck,Germany.228Institutefor
PaediatricNutritionMedicine,VestischeHospitalforChildrenandAdolescents,Universityof
Witten-Herdecke,Datteln,Germany.229DepartmentofMedicineIII,PreventionandCareof
Diabetes,UniversityofDresden,Dresden,Germany.230GeriatricsResearchandEducationClinical
Center,BaltimoreVeteransAdministrationMedicalCenter,Baltimore,Maryland,USA.231Hjelt
Institute,DepartmentofPublicHealth,UniversityofHelsinki,Helsinki,Finland.232South
OstrobothniaCentralHospital,Seinajoki,Finland.233DepartmentofInternalMedicine,Centre
HospitalierUniversitaireVaudois(CHUV)UniversityHospital,Lausanne,Switzerland.234The
BroadInstituteofHarvardandMassachusettsInstituteofTechnology(MIT),Cambridge,
Massachusetts,USA.235DepartmentofPsychiatry,HarvardMedicalSchool,Boston,
Massachusetts,USA.236PacificBiosciences,MenloPark,California,USA.237SageBionetworks,
Seattle,Washington,USA.238DivisionofBiostatistics,WashingtonUniversitySchoolofMedicine,
St.Louis,Missouri,USA.239DivisionofIntramuralResearch,NationalHeart,Lung,andBlood
Institute,FraminghamHeartStudy,Framingham,Massachusetts,USA.240Departmentof
EpidemiologyandPopulationHealth,AlbertEinsteinCollegeofMedicine,NewYork,NewYork,
USA.241DepartmentofGenetics,UniversityofNorthCarolina,ChapelHill,NorthCarolina,USA.
242DepartmentofMedicalGenetics,UniversityofHelsinki,Helsinki,Finland.243Laboratoryof
Genetics,NationalInstituteonAging,Baltimore,Maryland,USA.244DivisionofCommunityHealth
Sciences,St.George’s,UniversityofLondon,London,UK.245KlinikumGrosshadern,Munich,
Germany.246FacultyofMedicine,UniversityofIceland,Reykjavík,Iceland.247Universityof
CambridgeMetabolicResearchLabs,InstituteofMetabolicScienceAddenbrooke’sHospital,
Cambridge,UK.248CarolinaCenterforGenomeSciences,SchoolofPublicHealth,Universityof
NorthCarolinaChapelHill,ChapelHill,NorthCarolina,USA.249DepartmentofGenetics,Harvard
MedicalSchool,Boston,Massachusetts,USA.