Online Resource 4. Pooled TEWL estimates
Article title:
Transepidermal water loss in young and aged healthy humans:
a systematic review and meta-analysis
Journal name:
Archives of Dermatological Research
Authors:
Jan Kottner, Andrea Lichterfeld, Ulrike Blume-Peytavi
Corresponding author:
Jan Kottner
Charité-Universitätsmedizin Berlin
Department of Dermatology and Allergy
Clinical Research Center for Hair and Skin Science
Tel +49 (0)30 450 518 218
Fax +49 (0)30 450 518 952
Email: [email protected]
1
Online Resource 4. Pooled TEWL estimates
(1) Scalp
Summary meta-analysis plot [random effects]
Kleesz et al. 2012 (Tewameter 300)
11,00 (10,29, 11,71)
combined
11,00 (10,29, 11,71)
10,0
10,5
11,0
11,5
12,0
* difference (95% confidence interval)
2
Online Resource 4. Pooled TEWL estimates
(2) Forehead left
Summary meta-analysis plot [random effects]
Shah et al. 2005 (Vapometer)
17,10 (15,00, 19,20)
Shah et al. 2005 (Tewameter 210)
14,30 (12,93, 15,67)
combined
15,58 (12,85, 18,32)
10
12
14
16
18
20
* difference (95% confidence interval)
3
Online Resource 4. Pooled TEWL estimates
(3) Forehead mid
Summary meta-analysis plot [random effects]
Shah et al. 2005 (Vapometer)
22,70 (19,96, 25,44)
Shah et al. 2005 (Tewameter 210)
18,60 (15,76, 21,44)
combined
20,67 (16,65, 24,69)
15,0
17,5
20,0
22,5
25,0
27,5
* difference (95% confidence interval)
4
Online Resource 4. Pooled TEWL estimates
(4a) Forehead right all studies
Summary meta-analysis plot [random effects]
11,70 (11,03, 12,37)
Lotte et al. 1987 (Evaporimeter)
9,80 (9,43, 10,17)
Rougier et al. 1988 (Evaporimeter)
Cua et al. 1990 (Evaporimeter)
10,20 (9,18, 11,22)
Cua et al. 1990 (Evaporimeter)
7,40 (7,11, 7,69)
Cua, Wilhelm et al. 1990 (Evaporimeter)
7,10 (6,28, 7,92)
Cua, Wilhelm et al. 1990 (Evaporimeter)
4,80 (3,62, 5,98)
Wilhelm KP et al. 1991 (Evaporimeter)
10,50 (9,52, 11,48)
Wilhelm KP et al. 1991 (Evaporimeter)
7,50 (5,74, 9,26)
Barel, Clarys 1995 (Tewameter 210)
20,10 (17,75, 22,45)
Conti et al. 1995 (Evaporimeter)
14,20 (12,10, 16,30)
Barel, Clarys 1995 (Evaporimeter)
12,40 (10,75, 14,05)
Le Flur et al. 1999 (Evaporimeter)
8,40 (8,05, 8,75)
Lopez et al. 2000 (Evaporimeter)
9,60 (7,76, 11,44)
Shah et al. 2005 (Vapometer)
18,10 (16,34, 19,86)
Shah et al. 2005 (Tewameter 210)
14,90 (13,76, 16,04)
Marrakchi, Maibach 2007 (Evaporimeter)
7,60 (5,62, 9,58)
Marrakchi, Maibach 2007 (Evaporimeter)
6,90 (4,78, 9,02)
De Paepe et al. 2009 (Tewameter 210)
19,00 (17,04, 20,96)
De Paepe et al. 2009 (Tewameter 210)
15,10 (13,14, 17,06)
Machado et al. 2010 (Aqua Flux)
25,90 (24,53, 27,27)
Yang et al. 2010 (Vapometer)
13,10 (11,61, 14,59)
Klang et al. 2011 (Aqua Flux)
25,70 (23,05, 28,35)
Klang et al. 2011 (Aqua Flux)
25,00 (19,39, 30,61)
Klang et al. 2011 (Aqua Flux)
23,20 (20,91, 25,49)
Klang et al. 2011 (Aqua Flux)
20,90 (19,04, 22,76)
Kleesz et al. 2012 (Tewameter 300)
16,00 (15,12, 16,88)
combined
13,82 (12,25, 15,39)
0
6
12
18
24
30
36
* difference (95% confidence interval)
5
Online Resource 4. Pooled TEWL estimates
(4b) Forehead right studies including 18 to 64 year old subjects
Summary meta-analysis plot [random effects]
Rougier et al. 1988 (Evaporimeter)
9,80 (9,43, 10,17)
Cua et al. 1990 (Evaporimeter)
10,20 (9,18, 11,22)
Wilhelm KP et al. 1991 (Evaporimeter)
10,50 (9,52, 11,48)
Barel, Clarys 1995 (Evaporimeter)
12,40 (10,75, 14,05)
Barel, Clarys 1995 (Tewameter 210)
20,10 (17,75, 22,45)
Le Flur et al. 1999 (Evaporimeter)
8,40 (8,05, 8,75)
Lopez et al. 2000 (Evaporimeter)
9,60 (7,76, 11,44)
Marrakchi, Maibach 2007 (Evaporimeter)
6,90 (4,78, 9,02)
De Paepe et al. 2009 (Tewameter 210)
15,10 (13,14, 17,06)
De Paepe et al. 2009 (Tewameter 210)
19,00 (17,04, 20,96)
Machado et al. 2010 (Aqua Flux)
25,90 (24,53, 27,27)
Yang et al. 2010 (Vapometer)
13,10 (11,61, 14,59)
Klang et al. 2011 (Aqua Flux)
20,90 (19,04, 22,76)
Klang et al. 2011 (Aqua Flux)
23,20 (20,91, 25,49)
Klang et al. 2011 (Aqua Flux)
25,00 (19,39, 30,61)
Klang et al. 2011 (Aqua Flux)
25,70 (23,05, 28,35)
Kleesz et al. 2012 (Tewameter 300)
16,00 (15,12, 16,88)
combined
15,78 (13,52, 18,04)
0
6
12
18
24
30
36
* difference (95% confidence interval)
6
Online Resource 4. Pooled TEWL estimates
(4c) Forehead right studies including 65+ year old subjects
Summary meta-analysis plot [random effects]
Cua et al. 1990 (Evaporimeter)
7,40 (7,11, 7,69)
Wilhelm KP et al. 1991 (Evaporimeter)
7,50 (5,74, 9,26)
Marrakchi, Maibach 2007 (Evaporimeter)
7,60 (5,62, 9,58)
combined
7,41 (7,12, 7,69)
5
6
7
8
9
10
* difference (95% confidence interval)
7
Online Resource 4. Pooled TEWL estimates
(5a) Upper eyelid all studies
Summary meta-analysis plot [random effects]
Pratchyapruit et al. 2007 (Modell H4300)
14,00 (12,71, 15,29)
Marrakchi, Maibach 2007 (Evaporimeter)
11,60 (9,11, 14,09)
Marrakchi, Maibach 2007 (Evaporimeter)
9,50 (7,95, 11,05)
combined
11,73 (8,68, 14,77)
6
8
10
12
14
16
* difference (95% confidence interval)
8
Online Resource 4. Pooled TEWL estimates
(5b) Upper eyelid studies including 18 to 64 year old subjects
Summary meta-analysis plot [random effects]
Pratchyapruit et al. 2007 (Modell H4300)
14,00 (12,71, 15,29)
Marrakchi, Maibach 2007 (Evaporimeter)
9,50 (7,95, 11,05)
11,77 (7,36, 16,18)
combined
5
8
11
14
17
* difference (95% confidence interval)
9
Online Resource 4. Pooled TEWL estimates
(5c) Upper eyelid study including 65+ year old subjects
Summary meta-analysis plot [random effects]
Marrakchi, Maibach 2007 (Evaporimeter)
11,60 (9,11, 14,09)
combined
11,60 (9,11, 14,09)
8
10
12
14
16
* difference (95% confidence interval)
10
Online Resource 4. Pooled TEWL estimates
(6a) Periocular all studies
Summary meta-analysis plot [random effects]
Black et al. 2000 (Evaporimeter)
12,00 (10,08, 13,92)
Black et al. 2000 (Evaporimeter)
11,50 (9,93, 13,07)
Black et al. 2000 (Evaporimeter)
11,20 (9,98, 12,42)
Hillebrand et al. 2010 (Vapometer)
12,90 (12,25, 13,55)
Hillebrand et al. 2010 (Vapometer)
13,20 (12,53, 13,87)
Innocenti et al. 2010 (Tewameter 210)
14,70 (12,13, 17,27)
Yang et al. 2010 (Vapometer)
11,10 (10,00, 12,20)
combined
12,28 (11,47, 13,08)
8
10
12
14
16
18
* difference (95% confidence interval)
11
Online Resource 4. Pooled TEWL estimates
(6b) Periocular studies including 18 to 64 year old subjects
Summary meta-analysis plot [random effects]
Black et al. 2000 (Evaporimeter)
12,00 (10,08, 13,92)
Black et al. 2000 (Evaporimeter)
11,50 (9,93, 13,07)
Black et al. 2000 (Evaporimeter)
11,20 (9,98, 12,42)
Innocenti et al. 2010 (Tewameter 210)
14,70 (12,13, 17,27)
Yang et al. 2010 (Vapometer)
11,10 (10,00, 12,20)
combined
11,70 (10,79, 12,62)
8
10
12
14
16
18
* difference (95% confidence interval)
12
Online Resource 4. Pooled TEWL estimates
(7a) Nose all studies
Summary meta-analysis plot [random effects]
Marrakchi, Maibach 2007 (Evaporimeter)
9,80 (7,13, 12,47)
Marrakchi, Maibach 2007 (Evaporimeter)
9,40 (7,05, 11,75)
Pratchyapruit et al. 2007 (Modell H4300)
16,10 (14,39, 17,81)
combined
11,84 (7,12, 16,56)
5
8
11
14
17
20
* difference (95% confidence interval)
13
Online Resource 4. Pooled TEWL estimates
(7b) Nose studies including 18 to 64 year old subjects
Summary meta-analysis plot [random effects]
Marrakchi, Maibach 2007 (Evaporimeter)
9,40 (7,05, 11,75)
Pratchyapruit et al. 2007 (Modell H4300)
16,10 (14,39, 17,81)
combined
12,80 (6,24, 19,37)
5
10
15
20
* difference (95% confidence interval)
14
Online Resource 4. Pooled TEWL estimates
(7c) Nose study including 65+ year old subjects
Summary meta-analysis plot [random effects]
Marrakchi, Maibach 2007 (Evaporimeter)
9,80 (7,13, 12,47)
combined
9,80 (7,13, 12,47)
6
8
10
12
14
* difference (95% confidence interval)
15
Online Resource 4. Pooled TEWL estimates
(8) Lip
Summary meta-analysis plot [random effects]
Kobayashi, Tagami 2004b (Modell H4300)
35,00 (33,53, 36,47)
combined
35,00 (33,53, 36,47)
33
34
35
36
37
* difference (95% confidence interval)
16
Online Resource 4. Pooled TEWL estimates
(9) Cheek left
Summary meta-analysis plot [random effects]
Lopez et al. 2000 (Evaporimeter)
11,60 (9,76, 13,44)
combined
11,60 (9,76, 13,44)
9
10
11
12
13
14
* difference (95% confidence interval)
17
Online Resource 4. Pooled TEWL estimates
(10a) Cheek right all studies
Summary meta-analysis plot [random effects]
Conti et al. 1995 (Evaporimeter)
11,60 (9,64, 13,56)
Tanaka et al. 1997 (Evaporimeter)
10,00 (6,08, 13,92)
Le Flur et al. 1999 (Evaporimeter)
11,10 (10,59, 11,61)
Lopez et al. 2000 (Evaporimeter)
11,10 (9,26, 12,94)
Egawa et al. 2002 (Tewameter 210)
20,00 (18,04, 21,96)
Kikuchi et al. 2002 (Evaporimeter)
11,70 (9,47, 13,93)
Kikuchi et al.v 2002 (Evaporimeter)
8,10 (7,22, 8,98)
Kikuchi et al. 2002 (Evaporimeter)
10,50 (7,78, 13,22)
Kikuchi et al. 2002 (Evaporimeter)
5,30 (4,26, 6,34)
Tagami et al. 2002 (DermaLab5)
12,00 (11,57, 12,43)
Tagami et al. 2002 (Modell H4300)
6,40 (6,15, 6,65)
Kikuchi et al. 2003 (DermaLab5)
14,90 (13,18, 16,62)
Kobayashi et al. 2003 (DermaLab5)
15,00 (11,08, 18,92)
Kobayashi, Tagami 2004b (Modell H4300)
11,00 (10,43, 11,57)
Bornkessel et al. 2005 (Tewameter 300)
12,00 (10,43, 13,57)
Sunwoo et al. 2006a (Vapometer)
32,50 (24,19, 40,81)
Sunwoo et al. 2006a (Vapometer)
32,70 (29,23, 36,17)
Sunwoo et al. 2006b (Vapometer)
32,30 (26,91, 37,69)
Breternitz et al. 2007 (Tewameter 300)
14,50 (14,30, 14,70)
Marrakchi, Maibach 2007 (Evaporimeter)
7,10 (5,06, 9,14)
Marrakchi, Maibach 2007 (Evaporimeter)
7,10 (5,36, 8,84)
Pratchyapruit et al. 2007 (Modell H4300)
13,70 (12,15, 15,25)
Voegeli et al. 2007 (Aqua Flux)
28,60 (23,05, 34,15)
Voegeli et al. 2008 (Aqua Flux)
26,30 (21,97, 30,63)
Gardinier et al. 2009 (Tewameter 300)
22,70 (20,74, 24,66)
Mayes et al. 2009 (Aqua Flux)
30,90 (26,37, 35,43)
Mayes et al. 2009 (Aqua Flux)
27,50 (25,19, 29,81)
Mac-Mary et al. 2010 (Aqua Flux)
21,90 (17,80, 26,00)
Mac-Mary et al. 2010 (Aqua Flux)
19,60 (16,74, 22,46)
Baek et al. 2011 (Vapometer)
8,40 (7,24, 9,56)
Baek et al. 2011 (Vapometer)
10,50 (9,74, 11,26)
Baek et al. 2011 (Vapometer)
11,10 (10,36, 11,84)
Baek et al. 2011 (Vapometer)
10,10 (9,34, 10,86)
Kleesz et al. 2012 (Tewameter 300)
20,00 (19,12, 20,88)
combined
15,41 (13,86, 16,95)
0
10
20
30
40
50
* difference (95% confidence interval)
18
Online Resource 4. Pooled TEWL estimates
(10b) Cheek right studies including 18 to 64 year old subjects
Summary meta-analysis plot [random effects]
Tanaka et al. 1997 (Evaporimeter)
10,00 (6,08, 13,92)
Le Flur et al. 1999 (Evaporimeter)
11,10 (10,59, 11,61)
Lopez et al. 2000 (Evaporimeter)
11,10 (9,26, 12,94)
Egawa et al. 2002 (Tewameter 210)
20,00 (18,04, 21,96)
Kikuchi et al. 2003 (DermaLab5)
14,90 (13,18, 16,62)
Kobayashi et al. 2003 (DermaLab5)
15,00 (11,08, 18,92)
Bornkessel et al. 2005 (Tewameter 300)
12,00 (10,43, 13,57)
Sunwoo et al. 2006b (Vapometer)
32,30 (26,91, 37,69)
Breternitz et al. 2007 (Tewameter 300)
14,50 (14,30, 14,70)
Marrakchi, Maibach 2007 (Evaporimeter)
7,10 (5,36, 8,84)
Pratchyapruit et al. 2007 (Modell H4300)
13,70 (12,15, 15,25)
Voegeli et al. 2007 (Aqua Flux)
28,60 (23,05, 34,15)
Gardinier et al. 2009 (Tewameter 300)
22,70 (20,74, 24,66)
Baek et al. 2011 (Vapometer)
10,10 (9,34, 10,86)
Baek et al. 2011 (Vapometer)
11,10 (10,36, 11,84)
Baek et al. 2011 (Vapometer)
10,50 (9,74, 11,26)
Baek et al. 2011 (Vapometer)
8,40 (7,24, 9,56)
Kleesz et al. 2012 (Tewameter 300)
20,00 (19,12, 20,88)
combined
14,48 (12,89, 16,08)
0
10
20
30
40
* difference (95% confidence interval)
19
Online Resource 4. Pooled TEWL estimates
(10c) Cheek right study including 65+ year old subjects
Summary meta-analysis plot [random effects]
Marrakchi, Maibach 2007 (Evaporimeter)
7,10 (5,06, 9,14)
combined
7,10 (5,06, 9,14)
5
6
7
8
9
10
* difference (95% confidence interval)
20
Online Resource 4. Pooled TEWL estimates
(11) Nasolabial left
Summary meta-analysis plot [random effects]
De Paepe et al. 2009 (Tewameter 210)
29,50 (27,78, 31,22)
De Paepe et al. 2009 (Tewameter 210)
24,00 (22,04, 25,96)
combined
26,77 (21,38, 32,16)
20
23
26
29
32
35
* difference (95% confidence interval)
21
Online Resource 4. Pooled TEWL estimates
(12a) Nasolabial right all studies
Summary meta-analysis plot [random effects]
Marrakchi, Maibach 2007 (Evaporimeter)
14,00 (11,28, 16,72)
Marrakchi, Maibach 2007 (Evaporimeter)
18,60 (11,03, 26,17)
De Paepe et al. 2009 (Tewameter 210)
29,00 (26,79, 31,21)
De Paepe et al. 2009 (Tewameter 210)
23,50 (21,29, 25,71)
combined
21,46 (14,43, 28,49)
10
15
20
25
30
35
* difference (95% confidence interval)
22
Online Resource 4. Pooled TEWL estimates
(12b) Nasolabial right studies including 18 to 64 year old subjects
Summary meta-analysis plot [random effects]
Marrakchi, Maibach 2007 (Evaporimeter)
14,00 (11,28, 16,72)
De Paepe et al. 2009 (Tewameter 210)
29,00 (26,79, 31,21)
De Paepe et al. 2009 (Tewameter 210)
23,50 (21,29, 25,71)
combined
22,20 (14,09, 30,31)
10
14
18
22
26
30
34
* difference (95% confidence interval)
23
Online Resource 4. Pooled TEWL estimates
(12c) Nasolabial right study including 65+ year old subjects
Summary meta-analysis plot [random effects]
Marrakchi, Maibach 2007 (Evaporimeter)
18,60 (11,03, 26,17)
combined
18,60 (11,03, 26,17)
10
15
20
25
30
* difference (95% confidence interval)
24
Online Resource 4. Pooled TEWL estimates
(13a) Perioral all studies
Summary meta-analysis plot [random effects]
Marrakchi, Maibach 2007 (Evaporimeter)
15,80 (8,61, 22,99)
Marrakchi, Maibach 2007 (Evaporimeter)
12,30 (8,40, 16,20)
combined
13,10 (9,67, 16,52)
5
10
15
20
25
* difference (95% confidence interval)
25
Online Resource 4. Pooled TEWL estimates
(13b) Perioral study including 18 to 64 year old subjects
Summary meta-analysis plot [random effects]
Marrakchi, Maibach 2007 (Evaporimeter)
15,80 (8,61, 22,99)
combined
15,80 (8,61, 22,99)
5
10
15
20
25
* difference (95% confidence interval)
26
Online Resource 4. Pooled TEWL estimates
(13c) Perioral study including 65+ year old subjects
Summary meta-analysis plot [random effects]
Marrakchi, Maibach 2007 (Evaporimeter)
12,30 (8,40, 16,20)
combined
12,30 (8,40, 16,20)
8
11
14
17
* difference (95% confidence interval)
27
Online Resource 4. Pooled TEWL estimates
(14a) Postauricular all studies
Summary meta-analysis plot [random effects]
Lotte et al. 1987 (Evaporimeter)
8,50 (8,05, 8,95)
Rougier et al. 1988 (Evaporimeter)
8,40 (8,11, 8,69)
Cua, Wilhelm et al. 1990 (Evaporimeter)
6,60 (5,01, 8,19)
Cua, Wilhelm et al. 1990 (Evaporimeter)
6,10 (5,51, 6,69)
Cua et al. 1990 (Evaporimeter)
6,20 (5,81, 6,59)
Cua et al. 1990 (Evaporimeter)
5,60 (5,03, 6,17)
Wilhelm KP et al. 1991 (Evaporimeter)
6,50 (5,32, 7,68)
Wilhelm KP et al. 1991 (Evaporimeter)
6,00 (5,41, 6,59)
combined
6,76 (5,80, 7,71)
5
6
7
8
9
* difference (95% confidence interval)
28
Online Resource 4. Pooled TEWL estimates
(14b) Postauricular studies including 18 to 64 year old subjects
Summary meta-analysis plot [random effects]
Rougier et al. 1988 (Evaporimeter)
8,40 (8,11, 8,69)
Cua et al. 1990 (Evaporimeter)
5,60 (5,03, 6,17)
Wilhelm KP et al. 1991 (Evaporimeter)
6,00 (5,41, 6,59)
combined
6,68 (4,71, 8,65)
4
5
6
7
8
9
* difference (95% confidence interval)
29
Online Resource 4. Pooled TEWL estimates
(14c) Postauricular studies including 65+ year old subjects
Summary meta-analysis plot [random effects]
Cua et al. 1990 (Evaporimeter)
6,20 (5,81, 6,59)
Wilhelm KP et al. 1991 (Evaporimeter)
6,50 (5,32, 7,68)
combined
6,23 (5,86, 6,60)
5
6
7
8
* difference (95% confidence interval)
30
Online Resource 4. Pooled TEWL estimates
(15a) Chin all studies
Summary meta-analysis plot [random effects]
12,70 (11,47, 13,93)
Lopez et al. 2000 (Evaporimeter)
Marrakchi, Maibach 2007 (Evaporimeter)
10,90 (8,29, 13,51)
Marrakchi, Maibach 2007 (Evaporimeter)
9,50 (5,72, 13,28)
11,64 (9,85, 13,43)
combined
5
8
11
14
* difference (95% confidence interval)
31
Online Resource 4. Pooled TEWL estimates
(15b) Chin studies including 18 to 64 year old subjects
Summary meta-analysis plot [random effects]
12,70 (11,47, 13,93)
Lopez et al. 2000 (Evaporimeter)
9,50 (5,72, 13,28)
Marrakchi, Maibach 2007 (Evaporimeter)
combined
11,62 (8,65, 14,59)
5
7
9
11
13
15
* difference (95% confidence interval)
32
Online Resource 4. Pooled TEWL estimates
(15c) Chin study including 65+ year old subjects
Summary meta-analysis plot [random effects]
Marrakchi, Maibach 2007 (Evaporimeter)
10,90 (8,29, 13,51)
combined
10,90 (8,29, 13,51)
8
10
12
14
16
* difference (95% confidence interval)
33
Online Resource 4. Pooled TEWL estimates
(16a) Neck all studies
Summary meta-analysis plot [random effects]
Barel et al. 2001 (Tewameter 210)
5,40 (5,38, 5,42)
Marrakchi, Maibach 2007 (Evaporimeter)
7,90 (6,29, 9,51)
Marrakchi, Maibach 2007 (Evaporimeter)
9,60 (5,56, 13,64)
combined
7,13 (4,76, 9,50)
4
6
8
10
12
14
* difference (95% confidence interval)
34
Online Resource 4. Pooled TEWL estimates
(16b) Neck studies including 18 to 64 year old subjects
Summary meta-analysis plot [random effects]
Barel et al. 2001 (Tewameter 210)
5,40 (5,38, 5,42)
Marrakchi, Maibach 2007 (Evaporimeter)
9,60 (5,56, 13,64)
combined
6,99 (3,00, 10,99)
1
4
7
10
13
16
* difference (95% confidence interval)
35
Online Resource 4. Pooled TEWL estimates
(16c) Neck study including 65+ year old subjects
Summary meta-analysis plot [random effects]
Marrakchi, Maibach 2007 (Evaporimeter)
7,90 (6,29, 9,51)
combined
7,90 (6,29, 9,51)
6
7
8
9
10
* difference (95% confidence interval)
36
Online Resource 4. Pooled TEWL estimates
(17) Breast
Summary meta-analysis plot [random effects]
Kikuchi et al. 2011 (Modell H4300)
2,30 (1,93, 2,67)
combined
2,30 (1,93, 2,67)
1,9
2,1
2,3
2,5
2,7
* difference (95% confidence interval)
37
Online Resource 4. Pooled TEWL estimates
(18) Areola
Summary meta-analysis plot [random effects]
Kikuchi et al. 2011 (Modell H4300)
3,40 (2,18, 4,62)
combined
3,40 (2,18, 4,62)
2
3
4
5
* difference (95% confidence interval)
38
Online Resource 4. Pooled TEWL estimates
(19) Axilla
Summary meta-analysis plot [random effects]
Kleesz et al. 2012 (Tewameter 300)
44,00 (39,79, 48,21)
combined
44,00 (39,79, 48,21)
39
41
43
45
47
49
* difference (95% confidence interval)
39
Online Resource 4. Pooled TEWL estimates
(20a) Upper arm all studies
Summary meta-analysis plot [random effects]
Lotte et al. 1987 (Evaporimeter)
5,50 (5,03, 5,97)
Rougier et al. 1988 (Evaporimeter)
4,80 (4,66, 4,94)
Rougier et al. 1988 (Evaporimeter)
4,70 (4,37, 5,03)
Thune et al. 1988 (Evaporimeter)
4,60 (2,37, 6,83)
Thune 1989 (Evaporimeter)
4,80 (3,84, 5,76)
Thune 1989 (Evaporimeter)
4,60 (4,03, 5,17)
Thune 1989 (Evaporimeter)
6,60 (3,88, 9,32)
Cua et al. 1990 (Evaporimeter)
2,90 (2,76, 3,04)
Cua et al. 1990 (Evaporimeter)
4,00 (3,31, 4,69)
Cua, Wilhelm et al. 1990 (Evaporimeter)
1,80 (1,39, 2,21)
Cua, Wilhelm et al. 1990 (Evaporimeter)
3,80 (3,27, 4,33)
Wilhelm KP et al. 1991 (Evaporimeter)
3,00 (2,61, 3,39)
Wilhelm KP et al. 1991 (Evaporimeter)
4,00 (3,41, 4,59)
Barel et al. 2001 (Tewameter 210)
5,50 (5,48, 5,52)
Smith et al. 2004 (DermaLab5)
6,00 (5,02, 6,98)
Breternitz et al. 2007 (Tewameter 300)
10,00 (9,80, 10,20)
Chu, Kollias 2011 (Vapometer)
8,20 (7,02, 9,38)
Chu, Kollias 2011 (Vapometer)
7,50 (6,32, 8,68)
Chu, Kollias 2011 (Vapometer)
7,50 (6,52, 8,48)
Chu, Kollias 2011 (Vapometer)
6,00 (5,22, 6,78)
combined
5,25 (4,44, 6,05)
1
4
7
10
13
* difference (95% confidence interval)
40
Online Resource 4. Pooled TEWL estimates
(20b) Upper arm studies including 18 to 64 year old subjects
Summary meta-analysis plot [random effects]
Rougier et al. 1988 (Evaporimeter)
4,80 (4,66, 4,94)
Cua et al. 1990 (Evaporimeter)
4,00 (3,31, 4,69)
Wilhelm KP et al. 1991 (Evaporimeter)
4,00 (3,41, 4,59)
Barel et al. 2001 (Tewameter 210)
5,50 (5,48, 5,52)
Smith et al. 2004 (DermaLab5)
6,00 (5,02, 6,98)
Breternitz et al. 2007 (Tewameter 300)
10,00 (9,80, 10,20)
Chu, Kollias 2011 (Vapometer)
8,20 (7,02, 9,38)
Chu, Kollias 2011 (Vapometer)
7,50 (6,32, 8,68)
combined
6,23 (4,93, 7,53)
3
5
7
9
11
* difference (95% confidence interval)
41
Online Resource 4. Pooled TEWL estimates
(20c) Upper arm studies including 65+ year old subjects
Summary meta-analysis plot [random effects]
Rougier et al. 1988 (Evaporimeter)
4,70 (4,37, 5,03)
Thune et al. 1988 (Evaporimeter)
4,60 (2,37, 6,83)
Cua et al. 1990 (Evaporimeter)
2,90 (2,76, 3,04)
Wilhelm KP et al. 1991 (Evaporimeter)
3,00 (2,61, 3,39)
Chu, Kollias 2011 (Vapometer)
7,50 (6,52, 8,48)
Chu, Kollias 2011 (Vapometer)
6,00 (5,22, 6,78)
combined
4,73 (3,57, 5,88)
0,0
1,6
3,2
4,8
6,4
8,0
9,6
* difference (95% confidence interval)
42
Online Resource 4. Pooled TEWL estimates
(21a) Elbow ventral all studies
Summary meta-analysis plot [random effects]
Conti et al. 1995 (Evaporimeter)
5,00 (4,31, 5,69)
Machado et al. 2010 (Aqua Flux)
13,10 (12,51, 13,69)
Kleesz et al. 2012 (Tewameter 300)
10,00 (8,94, 11,06)
9,37 (4,01, 14,72)
combined
1
4
7
10
13
16
* difference (95% confidence interval)
43
Online Resource 4. Pooled TEWL estimates
(21b) Elbow ventral studies including 18 to 64 year old subjects
Summary meta-analysis plot [fixed effects]
Machado et al. 2010 (Aqua Flux)
13,10 (12,51, 13,69)
Kleesz et al. 2012 (Tewameter 300)
10,00 (8,94, 11,06)
combined
12,37 (11,85, 12,88)
8
10
12
14
* difference (95% confidence interval)
44
Online Resource 4. Pooled TEWL estimates
(22) Proximal left volar forearm
Summary meta-analysis plot [random effects]
Machado et al. 2010 (Aqua Flux)
12,50 (11,99, 13,01)
combined
12,50 (11,99, 13,01)
11,9
12,2
12,5
12,8
13,1
* difference (95% confidence interval)
45
Online Resource 4. Pooled TEWL estimates
(23a) Proximal right volar forearm all studies
Summary meta-analysis plot [random effects]
Rougier et al. 1988 (Evaporimeter)
2,50 (2,28, 2,72)
Van der Valk, Maibach 1989b (Evaporimeter)
2,80 (2,37, 3,23)
Panisset et al. 1992 (Evaporimeter)
3,10 (2,43, 3,77)
Shah et al. 2005 (Vapometer)
6,60 (5,68, 7,52)
Shah et al. 2005 (Tewameter 210)
6,40 (5,91, 6,89)
combined
4,26 (2,62, 5,90)
0
2
4
6
8
* difference (95% confidence interval)
46
Online Resource 4. Pooled TEWL estimates
(23b) Proximal right volar forearm studies including 18 to 64 year old subjects
Summary meta-analysis plot [random effects]
Rougier et al. 1988 (Evaporimeter)
2,50 (2,28, 2,72)
Van der Valk, Maibach 1989b (Evaporimeter)
2,80 (2,37, 3,23)
Panisset et al. 1992 (Evaporimeter)
3,10 (2,43, 3,77)
combined
2,70 (2,37, 3,02)
2,0
2,4
2,8
3,2
3,6
4,0
* difference (95% confidence interval)
47
Online Resource 4. Pooled TEWL estimates
(24a) Midvolar left forearm all studies
Summary meta-analysis plot [random effects]
Oestmann et al. 1993 (Evaporimeter)
5,50 (5,40, 5,60)
Treffel et al 1994 (Evaporimeter)
2,90 (2,66, 3,14)
Chilcott, Farrar 2000 (Evaporimeter)
4,80 (4,37, 5,23)
De Paepe et al. 2000 (Tewameter 210)
5,10 (4,12, 6,08)
Rodrrigues et al. 2004 (Tewameter 210)
12,90 (11,45, 14,35)
Savic et al. 2004 (Tewameter 210)
7,50 (6,79, 8,21)
Pedersen, Jemec 2006 (DermaLab5)
14,90 (14,65, 15,15)
Jung et al. 2007 (Tewameter 210)
9,50 (8,72, 10,28)
Marrakchi, Maibach 2007 (Evaporimeter)
2,70 (1,90, 3,50)
Marrakchi, Maibach 2007 (Evaporimeter)
3,90 (2,23, 5,57)
Harmsze et al. 2008 (Tewameter 300)
8,60 (5,90, 11,30)
Machado et al. 2010 (Aqua Flux)
13,00 (12,39, 13,61)
Klang et al. 2011 (Aqua Flux)
12,10 (10,51, 13,69)
Klang et al. 2011 (Aqua Flux)
11,70 (9,60, 13,80)
Klang et al. 2011 (Aqua Flux)
10,60 (9,35, 11,85)
Klang et al. 2011 (Aqua Flux)
11,00 (10,29, 11,71)
Kleesz et al. 2012 (Tewameter 300)
11,00 (10,29, 11,71)
combined
8,68 (6,52, 10,83)
0
4
8
12
16
* difference (95% confidence interval)
48
Online Resource 4. Pooled TEWL estimates
(24b) Midvolar left forearm studies including 18 to 64 year old subjects
Summary meta-analysis plot [random effects]
Oestmann et al. 1993 (Evaporimeter)
5,50 (5,40, 5,60)
Chilcott, Farrar 2000 (Evaporimeter)
4,80 (4,37, 5,23)
De Paepe et al. 2000 (Tewameter 210)
5,10 (4,12, 6,08)
Rodrrigues et al. 2004 (Tewameter 210)
12,90 (11,45, 14,35)
Pedersen, Jemec 2006 (DermaLab5)
14,90 (14,65, 15,15)
Marrakchi, Maibach 2007 (Evaporimeter)
3,90 (2,23, 5,57)
Harmsze et al. 2008 (Tewameter 300)
8,60 (5,90, 11,30)
Machado et al. 2010 (Aqua Flux)
13,00 (12,39, 13,61)
Klang et al. 2011 (Aqua Flux)
12,10 (10,51, 13,69)
Klang et al. 2011 (Aqua Flux)
11,70 (9,60, 13,80)
Klang et al. 2011 (Aqua Flux)
10,60 (9,35, 11,85)
Klang et al. 2011 (Aqua Flux)
11,00 (10,29, 11,71)
Kleesz et al. 2012 (Tewameter 300)
11,00 (10,29, 11,71)
combined
9,62 (6,76, 12,48)
0
4
8
12
16
* difference (95% confidence interval)
49
Online Resource 4. Pooled TEWL estimates
(24c) Midvolar left forearm study including 65+ year old subjects
Summary meta-analysis plot [random effects]
Marrakchi, Maibach 2007 (Evaporimeter)
2,70 (1,90, 3,50)
combined
2,70 (1,90, 3,50)
1,8
2,3
2,8
3,3
3,8
* difference (95% confidence interval)
50
Online Resource 4. Pooled TEWL estimates
(25a) Midvolar right forearm all studies
51
Online Resource 4. Pooled TEWL estimates
Summary meta-analysis plot [random effects]
Tagami, Yoshikuni 1985 (Evaporimeter)
Blichmann, Serup 1987 (Evaporimeter)
Blichmann, Serup 1988 (Evaporimeter)
Rougier et al. 1988 (Evaporimeter)
Pinnagoda et al. 1989a (Evaporimeter)
Pinnagoda et al. 1989b (Evaporimeter)
Pinnagoda et al. 1989b (Evaporimeter)
Pinnagoda et al. 1989b (Evaporimeter)
Pinnagoda et al.1989c (Evaporimeter)
Roskos, Guy 1989 (Evaporimeter)
Roskos, Guy 1989 (Evaporimeter)
Tupker et al. 1989a (Evaporimeter)
Tupker et al. 1989b (Evaporimeter)
Van der Valk et al. 1989a (Evaporimeter)
Van der Valk, Maibach 1989b (Evaporimeter)
Agner, Serup 1990c (Evaporimeter)
Berardesca et al. 1990 (Evaporimeter)
Cua et al. 1990 (Evaporimeter)
Cua et al. 1990 (Evaporimeter)
Cua, Wilhelm et al. 1990 (Evaporimeter)
Cua, Wilhelm et al. 1990 (Evaporimeter)
Elsner et al. 1990a (Evaporimeter)
Elsner et al. 1990a (Evaporimeter)
Elsner et al. 1990b (Evaporimeter)
Elsner et al. 1990b (Evaporimeter)
Elsner, Maibach 1990c (Evaporimeter)
Lo et al. 1990 (Evaporimeter)
Tupker et al. 1990a (Evaporimeter)
Wilhelm et al. 1990a (Evaporimeter)
Wilhelm, Maibach 1990 (Evaporimeter)
Berardesca et al. 1991 (Evaporimeter)
Berardesca et al. 1991 (Evaporimeter)
Berardesca et al. 1991 (Evaporimeter)
Doucet et al. 1991 (Evaporimeter)
Schulz et al. 1991 (Evaporimeter)
Wilhelm KP et al. 1991 (Evaporimeter)
Wilhelm KP et al. 1991 (Evaporimeter)
Wilhelm D et al. 1991 (Evaporimeter)
Loden 1992 (Evaporimeter)
Panisset et al. 1992 (Evaporimeter)
Kompaore et al. 1993 (Evaporimeter)
Kompaore et al. 1993 (Evaporimeter)
Kompaore et al. 1993 (Evaporimeter)
Oestmann et al. 1993 (Evaporimeter)
Wilhelm et al. 1993 (Evaporimeter)
Hartmann et al. 1994 (Tewameter 210)
Hartmann et al. 1994 (Tewameter 210)
Hartmann et al. 1994 (Tewameter 210)
Treffel et al 1994 (Evaporimeter)
Barel, Clarys 1995 (Tewameter 210)
Barel, Clarys 1995 (Evaporimeter)
Berardesca et al. 1995 (Evaporimeter)
Conti et al. 1995 (Evaporimeter)
Effendy et al. 1995a (Tewameter 210)
Ghadially et al. 1995 (Evaporimeter)
Ghadially et al. 1995 (Evaporimeter)
Lavrijsen et al. 1995 (Evaporimeter)
Nicander et al. 1995 (Evaporimeter)
Pierard et al. 1995a (Evaporimeter)
Reed et al. 1995 (Evaporimeter)
Reed et al. 1995 (Evaporimeter)
Snater et al. 1995 (Tewameter 210)
Treffel, Gabard 1995 (Evaporimeter)
Treffel, Gabard 1995 (Evaporimeter)
Kalia et al. 1996 (Evaporimeter)
Loden 1996 (Evaporimeter)
Löffler et al. 1996 (Tewameter 210)
Fartasch et al. 1997 (Tewameter 210)
Gfesser et al. 1997 (Evaporimeter)
Lintner et al. 1997 (Evaporimeter)
Lintner et al. 1997 (Tewameter 210)
Loden 1997 (Evaporimeter)
Berardesca et al. 1998 (Tewameter 210)
Berardesca et al. 1998 (Tewameter 210)
Kolbe et al. 1998 (Evaporimeter)
Seidenari et al. 1998 (Evaporimeter)
Welzel et al. 1998 (Tewameter 210)
Black et al. 2000 (Evaporimeter)
Black et al. 2000 (Evaporimeter)
Black et al. 2000 (Evaporimeter)
Chilcott, Farrar 2000 (Evaporimeter)
De Paepe et al. 2000 (Tewameter 210)
Gehring, Gloor 2000 (Tewameter 210)
Gehring, Gloor 2000 (Tewameter 210)
Kalia et al. 2000 (Evaporimeter)
Zhai et al. 2000 (Tewameter 210)
Barel et al. 2001 (Tewameter 210)
Kolbe et al. 2001 (Evaporimeter)
Yoshizawa et al. 2001 (Tewameter 210)
Hun Huh et al. 2002 (Tewameter 210)
Said et al. 2002 (Evaporimeter)
Tagami et al. 2002 (DermaLab5)
Tagami et al. 2002 (Modell H4300)
Kobayashi et al. 2003 (DermaLab5)
Welzel et al. 2003 (Tewameter 210)
Koopman et al. 2004 (Vapometer)
Savic et al. 2004 (Tewameter 210)
Bornkessel et al. 2005 (Tewameter 300)
Chou et al. 2005 (Tewameter 210)
De Paepe 2005 (Vapometer)
De Paepe 2005 (Tewameter 210)
Jacobi et al. 2005 (Tewameter 210)
Li et al. 2005 (Tewameter 210)
Muggli 2005 (Tewameter 300)
Nielsen et al. 2005 (Derma Lab5)
Rosado et al. 2005 (Tewameter 300)
Rosado et al. 2005 (Tewameter 210)
Shah et al. 2005 (Vapometer)
Shah et al. 2005 (Tewameter 210)
Waller et al. 2005 (Vapometer)
Brandner et al. 2006 (Vapometer)
Dal`Belo et al. 2006 (Tewameter 210)
De Jongh et al. 2006a (Vapometer)
De Jongh et al. 2006b (Vapometer)
Fluhr et al 2006 (Evaporimeter)
Fluhr et al 2006 (Tewameter 210)
Fluhr et al 2006 (Tewameter 300)
Fluhr et al 2006 (DermaLab5)
Fluhr et al 2006 (Vapometer)
Fluhr et al 2006 (Modell H4300)
Fluhr et al 2006 (MEECO)
Jakasa et al. 2006a (Vapometer)
Jakasa et al. 2006b (Vapometer)
Breternitz et al. 2007 (Tewameter 300)
Ortonne et al. 2007 (Tewameter 300)
Voegeli et al. 2007 (Aqua Flux)
Cheng et al. 2008 (Tewameter 300)
De Paepe et al. 2008 (Tewameter 300)
Johnsen et al 2008 (Tewameter 300)
Puch et al. 2008 (Evaporimeter)
Russell et al. 2008 (Aqua Flux)
Xhauflaire-Uhoda et al. 2008 (Tewameter 210)
Gardinier et al. 2009 (Tewameter 300)
Atrux-Tallau et al. 2010 (Vapometer)
Guida et al. 2010 (Vapometer)
Tsang, Guy 2010 (Aqua Flux)
Fluhr et al. 2011 (Tewameter 300)
Klang et al. 2011 (Aqua Flux)
Klang et al. 2011 (Aqua Flux)
Klang et al. 2011 (Aqua Flux)
Klang et al. 2011 (Aqua Flux)
Lee et al. 2011 (Vapometer)
Mohammed et al. 2011a (Aqua Flux)
Mohammed et al. 2011b (Aqua Flux)
Yamamoto et al. 2011 (Vapometer)
Yamamoto et al. 2011 (Vapometer)
Yamamoto et al. 2011 (Vapometer)
Kleesz et al. 2012 (Tewameter 300)
combined
6,00 (4,04, 7,96)
5,70 (4,09, 7,31)
5,50 (4,44, 6,56)
4,00 (3,78, 4,22)
5,40 (4,93, 5,87)
4,50 (3,91, 5,09)
4,90 (4,31, 5,49)
4,30 (3,75, 4,85)
6,50 (5,87, 7,13)
4,80 (4,27, 5,33)
3,90 (2,90, 4,90)
4,90 (4,25, 5,55)
5,10 (4,51, 5,69)
3,60 (3,07, 4,13)
2,80 (2,17, 3,43)
6,30 (6,10, 6,50)
6,10 (4,98, 7,22)
3,90 (3,27, 4,53)
2,60 (2,42, 2,78)
2,30 (1,75, 2,85)
5,00 (3,96, 6,04)
4,80 (3,37, 6,23)
3,80 (3,55, 4,05)
3,70 (2,92, 4,48)
2,60 (2,40, 2,80)
13,40 (12,62, 14,18)
3,00 (2,55, 3,45)
6,00 (5,57, 6,43)
5,00 (4,41, 5,59)
4,20 (3,61, 4,79)
2,20 (2,12, 2,28)
3,20 (3,06, 3,34)
2,70 (2,56, 2,84)
4,20 (4,04, 4,36)
4,20 (4,00, 4,40)
3,00 (2,61, 3,39)
4,00 (3,61, 4,39)
7,40 (6,28, 8,52)
5,30 (4,56, 6,04)
3,00 (2,49, 3,51)
3,60 (3,50, 3,70)
4,50 (4,40, 4,60)
4,60 (4,38, 4,82)
5,60 (5,50, 5,70)
4,00 (1,82, 6,18)
12,00 (10,28, 13,72)
11,00 (9,57, 12,43)
9,00 (7,94, 10,06)
3,20 (2,96, 3,44)
10,40 (8,87, 11,93)
5,20 (4,12, 6,28)
6,00 (5,20, 6,80)
3,90 (3,27, 4,53)
7,20 (6,67, 7,73)
6,40 (5,66, 7,14)
4,40 (4,26, 4,54)
5,10 (4,51, 5,69)
6,10 (2,42, 9,78)
4,60 (4,33, 4,87)
4,80 (4,53, 5,07)
5,10 (4,61, 5,59)
9,10 (7,57, 10,63)
4,20 (3,47, 4,93)
4,10 (3,06, 5,14)
6,60 (4,68, 8,52)
6,10 (5,59, 6,61)
7,10 (6,57, 7,63)
9,10 (7,18, 11,02)
5,80 (5,11, 6,49)
5,30 (4,54, 6,06)
9,80 (8,09, 11,51)
6,40 (5,09, 7,71)
7,30 (6,73, 7,87)
7,70 (7,07, 8,33)
4,80 (3,80, 5,80)
5,20 (4,55, 5,85)
10,00 (8,69, 11,31)
8,50 (7,30, 9,70)
6,50 (5,42, 7,58)
6,00 (5,20, 6,80)
4,80 (4,41, 5,19)
5,60 (4,11, 7,09)
5,60 (4,68, 6,52)
5,80 (5,13, 6,47)
7,00 (6,02, 7,98)
8,00 (7,49, 8,51)
5,50 (5,48, 5,52)
4,80 (4,23, 5,37)
12,10 (11,12, 13,08)
3,30 (2,77, 3,83)
9,50 (8,72, 10,28)
4,70 (4,48, 4,92)
2,30 (2,22, 2,38)
4,90 (4,70, 5,10)
6,30 (5,34, 7,26)
10,40 (9,54, 11,26)
7,80 (7,07, 8,53)
7,70 (7,11, 8,29)
10,00 (9,22, 10,78)
7,00 (5,53, 8,47)
12,50 (11,32, 13,68)
11,80 (9,76, 13,84)
7,00 (5,59, 8,41)
9,10 (8,61, 9,59)
6,30 (0,24, 12,36)
8,10 (6,73, 9,47)
10,80 (9,58, 12,02)
6,60 (5,68, 7,52)
6,40 (5,91, 6,89)
9,00 (7,47, 10,53)
21,30 (19,83, 22,77)
7,80 (7,11, 8,49)
8,60 (7,17, 10,03)
9,00 (7,69, 10,31)
4,00 (3,41, 4,59)
6,20 (4,63, 7,77)
12,00 (10,04, 13,96)
2,00 (1,22, 2,78)
5,90 (3,94, 7,86)
4,50 (2,34, 6,66)
1,90 (1,70, 2,10)
6,30 (5,42, 7,18)
6,30 (5,38, 7,22)
8,00 (7,80, 8,20)
8,40 (7,32, 9,48)
13,50 (11,72, 15,28)
8,00 (7,27, 8,73)
12,00 (11,31, 12,69)
4,70 (3,92, 5,48)
4,20 (3,71, 4,69)
10,10 (8,87, 11,33)
8,20 (7,75, 8,65)
8,80 (7,82, 9,78)
5,90 (5,65, 6,15)
18,40 (15,95, 20,85)
12,30 (9,42, 15,18)
7,40 (5,85, 8,95)
11,70 (10,80, 12,60)
11,40 (10,52, 12,28)
13,10 (11,12, 15,08)
12,00 (10,06, 13,94)
5,50 (4,52, 6,48)
11,60 (10,42, 12,78)
9,80 (9,21, 10,39)
5,80 (5,29, 6,31)
6,10 (5,41, 6,79)
3,90 (3,27, 4,53)
11,00 (10,29, 11,71)
6,53 (6,24, 6,81)
0
10
20
30
* difference (95% confidence interval)
52
Online Resource 4. Pooled TEWL estimates
(25b) Midvolar right forearm studies including 18 to 64 year old subjects
53
Online Resource 4. Pooled TEWL estimates
Summary meta-analysis plot [random effects]
Tagami, Yoshikuni 1985 (Evaporimeter)
6,00 (4,04, 7,96)
Blichmann, Serup 1987 (Evaporimeter)
5,70 (4,09, 7,31)
Blichmann, Serup 1988 (Evaporimeter)
5,50 (4,44, 6,56)
Rougier et al. 1988 (Evaporimeter)
4,00 (3,78, 4,22)
Pinnagoda et al. 1989a (Evaporimeter)
5,40 (4,93, 5,87)
Pinnagoda et al. 1989b (Evaporimeter)
4,50 (3,91, 5,09)
Pinnagoda et al. 1989b (Evaporimeter)
4,90 (4,31, 5,49)
Pinnagoda et al. 1989b (Evaporimeter)
4,30 (3,75, 4,85)
Pinnagoda et al.1989c (Evaporimeter)
6,50 (5,87, 7,13)
Roskos, Guy 1989 (Evaporimeter)
4,80 (4,27, 5,33)
Tupker et al. 1989a (Evaporimeter)
4,90 (4,25, 5,55)
Tupker et al. 1989b (Evaporimeter)
5,10 (4,51, 5,69)
Van der Valk, Maibach 1989b (Evaporimeter)
2,80 (2,17, 3,43)
Agner, Serup 1990c (Evaporimeter)
6,30 (6,10, 6,50)
Berardesca et al. 1990 (Evaporimeter)
6,10 (4,98, 7,22)
Cua et al. 1990 (Evaporimeter)
3,90 (3,27, 4,53)
Elsner et al. 1990a (Evaporimeter)
3,80 (3,55, 4,05)
Elsner et al. 1990b (Evaporimeter)
3,70 (2,92, 4,48)
Lo et al. 1990 (Evaporimeter)
3,00 (2,55, 3,45)
Tupker et al. 1990a (Evaporimeter)
6,00 (5,57, 6,43)
Wilhelm et al. 1990a (Evaporimeter)
5,00 (4,41, 5,59)
Wilhelm, Maibach 1990 (Evaporimeter)
4,20 (3,61, 4,79)
Doucet et al. 1991 (Evaporimeter)
4,20 (4,04, 4,36)
Wilhelm KP et al. 1991 (Evaporimeter)
4,00 (3,61, 4,39)
Wilhelm D et al. 1991 (Evaporimeter)
7,40 (6,28, 8,52)
Loden 1992 (Evaporimeter)
5,30 (4,56, 6,04)
Panisset et al. 1992 (Evaporimeter)
3,00 (2,49, 3,51)
Kompaore et al. 1993 (Evaporimeter)
3,60 (3,50, 3,70)
Kompaore et al. 1993 (Evaporimeter)
4,50 (4,40, 4,60)
Kompaore et al. 1993 (Evaporimeter)
4,60 (4,38, 4,82)
Oestmann et al. 1993 (Evaporimeter)
5,60 (5,50, 5,70)
Wilhelm et al. 1993 (Evaporimeter)
4,00 (1,82, 6,18)
Hartmann et al. 1994 (Tewameter 210)
12,00 (10,28, 13,72)
Hartmann et al. 1994 (Tewameter 210)
11,00 (9,57, 12,43)
Hartmann et al. 1994 (Tewameter 210)
9,00 (7,94, 10,06)
Barel, Clarys 1995 (Tewameter 210)
10,40 (8,87, 11,93)
Barel, Clarys 1995 (Evaporimeter)
5,20 (4,12, 6,28)
Effendy et al. 1995a (Tewameter 210)
7,20 (6,67, 7,73)
Ghadially et al. 1995 (Evaporimeter)
6,40 (5,66, 7,14)
Lavrijsen et al. 1995 (Evaporimeter)
5,10 (4,51, 5,69)
Nicander et al. 1995 (Evaporimeter)
6,10 (2,42, 9,78)
Reed et al. 1995 (Evaporimeter)
4,80 (4,53, 5,07)
Reed et al. 1995 (Evaporimeter)
5,10 (4,61, 5,59)
Snater et al. 1995 (Tewameter 210)
9,10 (7,57, 10,63)
Treffel, Gabard 1995 (Evaporimeter)
4,20 (3,47, 4,93)
Treffel, Gabard 1995 (Evaporimeter)
4,10 (3,06, 5,14)
Kalia et al. 1996 (Evaporimeter)
6,60 (4,68, 8,52)
Loden 1996 (Evaporimeter)
6,10 (5,59, 6,61)
Löffler et al. 1996 (Tewameter 210)
7,10 (6,57, 7,63)
Fartasch et al. 1997 (Tewameter 210)
9,10 (7,18, 11,02)
Gfesser et al. 1997 (Evaporimeter)
5,80 (5,11, 6,49)
Lintner et al. 1997 (Evaporimeter)
5,30 (4,54, 6,06)
Lintner et al. 1997 (Tewameter 210)
9,80 (8,09, 11,51)
Loden 1997 (Evaporimeter)
6,40 (5,09, 7,71)
Seidenari et al. 1998 (Evaporimeter)
5,20 (4,55, 5,85)
Welzel et al. 1998 (Tewameter 210)
10,00 (8,69, 11,31)
Black et al. 2000 (Evaporimeter)
8,50 (7,30, 9,70)
Black et al. 2000 (Evaporimeter)
6,50 (5,42, 7,58)
Black et al. 2000 (Evaporimeter)
6,00 (5,20, 6,80)
Chilcott, Farrar 2000 (Evaporimeter)
4,80 (4,41, 5,19)
De Paepe et al. 2000 (Tewameter 210)
5,60 (4,11, 7,09)
Gehring, Gloor 2000 (Tewameter 210)
5,60 (4,68, 6,52)
Gehring, Gloor 2000 (Tewameter 210)
5,80 (5,13, 6,47)
Kalia et al. 2000 (Evaporimeter)
7,00 (6,02, 7,98)
Barel et al. 2001 (Tewameter 210)
5,50 (5,48, 5,52)
Kolbe et al. 2001 (Evaporimeter)
4,80 (4,23, 5,37)
Hun Huh et al. 2002 (Tewameter 210)
3,30 (2,77, 3,83)
Said et al. 2002 (Evaporimeter)
9,50 (8,72, 10,28)
Kobayashi et al. 2003 (DermaLab5)
4,90 (4,70, 5,10)
Welzel et al. 2003 (Tewameter 210)
6,30 (5,34, 7,26)
Koopman et al. 2004 (Vapometer)
10,40 (9,54, 11,26)
Bornkessel et al. 2005 (Tewameter 300)
7,70 (7,11, 8,29)
De Paepe 2005 (Vapometer)
7,00 (5,53, 8,47)
De Paepe 2005 (Tewameter 210)
12,50 (11,32, 13,68)
Li et al. 2005 (Tewameter 210)
7,00 (5,59, 8,41)
Muggli 2005 (Tewameter 300)
9,10 (8,61, 9,59)
Nielsen et al. 2005 (Derma Lab5)
6,30 (0,24, 12,36)
Brandner et al. 2006 (Vapometer)
21,30 (19,83, 22,77)
Dal`Belo et al. 2006 (Tewameter 210)
7,80 (7,11, 8,49)
Fluhr et al 2006 (Evaporimeter)
4,00 (3,41, 4,59)
Fluhr et al 2006 (Tewameter 210)
6,20 (4,63, 7,77)
Fluhr et al 2006 (Tewameter 300)
12,00 (10,04, 13,96)
Fluhr et al 2006 (DermaLab5)
2,00 (1,22, 2,78)
Fluhr et al 2006 (Vapometer)
5,90 (3,94, 7,86)
Fluhr et al 2006 (Modell H4300)
4,50 (2,34, 6,66)
Fluhr et al 2006 (MEECO)
1,90 (1,70, 2,10)
Jakasa et al. 2006a (Vapometer)
6,30 (5,42, 7,18)
Jakasa et al. 2006b (Vapometer)
6,30 (5,38, 7,22)
Breternitz et al. 2007 (Tewameter 300)
8,00 (7,80, 8,20)
Ortonne et al. 2007 (Tewameter 300)
8,40 (7,32, 9,48)
Voegeli et al. 2007 (Aqua Flux)
13,50 (11,72, 15,28)
Cheng et al. 2008 (Tewameter 300)
8,00 (7,27, 8,73)
De Paepe et al. 2008 (Tewameter 300)
12,00 (11,31, 12,69)
Johnsen et al 2008 (Tewameter 300)
4,70 (3,92, 5,48)
Puch et al. 2008 (Evaporimeter)
4,20 (3,71, 4,69)
Russell et al. 2008 (Aqua Flux)
10,10 (8,87, 11,33)
Gardinier et al. 2009 (Tewameter 300)
8,80 (7,82, 9,78)
Atrux-Tallau et al. 2010 (Vapometer)
5,90 (5,65, 6,15)
Tsang, Guy 2010 (Aqua Flux)
12,30 (9,42, 15,18)
Fluhr et al. 2011 (Tewameter 300)
7,40 (5,85, 8,95)
Klang et al. 2011 (Aqua Flux)
11,70 (10,80, 12,60)
Klang et al. 2011 (Aqua Flux)
11,40 (10,52, 12,28)
Klang et al. 2011 (Aqua Flux)
13,10 (11,12, 15,08)
Klang et al. 2011 (Aqua Flux)
12,00 (10,06, 13,94)
Mohammed et al. 2011a (Aqua Flux)
11,60 (10,42, 12,78)
Mohammed et al. 2011b (Aqua Flux)
9,80 (9,21, 10,39)
Yamamoto et al. 2011 (Vapometer)
6,10 (5,41, 6,79)
Yamamoto et al. 2011 (Vapometer)
3,90 (3,27, 4,53)
Kleesz et al. 2012 (Tewameter 300)
11,00 (10,29, 11,71)
combined
6,59 (6,33, 6,86)
0
10
20
30
* difference (95% confidence interval)
54
Online Resource 4. Pooled TEWL estimates
(25c) Midvolar right forearm studies including 65+ year old subjects
Summary meta-analysis plot [random effects]
Roskos, Guy 1989 (Evaporimeter)
3,90 (2,90, 4,90)
Cua et al. 1990 (Evaporimeter)
2,60 (2,42, 2,78)
Wilhelm KP et al. 1991 (Evaporimeter)
3,00 (2,61, 3,39)
Ghadially et al. 1995 (Evaporimeter)
4,40 (4,26, 4,54)
combined
3,46 (2,30, 4,62)
2
3
4
5
* difference (95% confidence interval)
55
Online Resource 4. Pooled TEWL estimates
(26a) Distal left volar forearm all studies
Summary meta-analysis plot [random effects]
4,30 (3,28, 5,32)
Benfeldt et al. 1999 (Evaporimeter)
Hachem et al. 2002 (Tewameter 210)
12,00 (11,06, 12,94)
Hachem et al. 2002 (Tewameter 210)
23,80 (21,23, 26,37)
Machado et al. 2010 (Aqua Flux)
19,80 (18,88, 20,72)
combined
14,92 (7,21, 22,64)
0
10
20
30
* difference (95% confidence interval)
56
Online Resource 4. Pooled TEWL estimates
(26b) Distal left volar forearm studies including 18 to 64 year old subjects
Summary meta-analysis plot [random effects]
Hachem et al. 2002 (Tewameter 210)
23,80 (21,23, 26,37)
Hachem et al. 2002 (Tewameter 210)
12,00 (11,06, 12,94)
Machado et al. 2010 (Aqua Flux)
19,80 (18,88, 20,72)
combined
18,45 (12,02, 24,89)
10
15
20
25
30
* difference (95% confidence interval)
57
Online Resource 4. Pooled TEWL estimates
(27a) Distal right volar forearm all studies
Summary meta-analysis plot [random effects]
Rougier et al. 1988 (Evaporimeter)
7,20 (6,91, 7,49)
Van der Valk, Maibach 1989b (Evaporimeter)
5,40 (3,36, 7,44)
Panisset et al. 1992 (Evaporimeter)
4,20 (3,36, 5,04)
Hachem et al. 2002 (Tewameter 210)
24,90 (21,94, 27,86)
Hachem et al. 2002 (Tewameter 210)
13,20 (11,98, 14,42)
Shah et al. 2005 (Vapometer)
7,60 (6,62, 8,58)
Shah et al. 2005 (Tewameter 210)
7,10 (6,32, 7,88)
combined
9,56 (7,31, 11,82)
0
10
20
30
* difference (95% confidence interval)
58
Online Resource 4. Pooled TEWL estimates
(26b) Distal right volar forearm studies including 18 to 64 year old subjects
Summary meta-analysis plot [random effects]
Rougier et al. 1988 (Evaporimeter)
7,20 (6,91, 7,49)
Van der Valk, Maibach 1989b (Evaporimeter)
5,40 (3,36, 7,44)
Panisset et al. 1992 (Evaporimeter)
4,20 (3,36, 5,04)
Hachem et al. 2002 (Tewameter 210)
24,90 (21,94, 27,86)
Hachem et al. 2002 (Tewameter 210)
13,20 (11,98, 14,42)
combined
10,71 (7,02, 14,40)
0
10
20
30
* difference (95% confidence interval)
59
Online Resource 4. Pooled TEWL estimates
(28a) Forearm left dorsal all studies
Summary meta-analysis plot [random effects]
Kligman et al. 1979 (other)
16,00 (12,28, 19,72)
Cua, Wilhelm et al. 1990 (Evaporimeter)
2,10 (1,55, 2,65)
Cua, Wilhelm et al. 1990 (Evaporimeter)
3,80 (3,27, 4,33)
Berardesca et al. 1991 (Evaporimeter)
2,90 (2,70, 3,10)
Berardesca et al. 1991 (Evaporimeter)
2,80 (2,60, 3,00)
Berardesca et al. 1991 (Evaporimeter)
2,60 (2,50, 2,70)
Wilhelm KP et al. 1991 (Evaporimeter)
3,00 (2,61, 3,39)
Wilhelm KP et al. 1991 (Evaporimeter)
4,00 (3,41, 4,59)
Oestmann et al. 1993 (Evaporimeter)
5,30 (5,20, 5,40)
combined
3,92 (2,87, 4,96)
0
5
10
15
20
* difference (95% confidence interval)
60
Online Resource 4. Pooled TEWL estimates
(28b) Forearm left dorsal studies including 18 to 64 year old subjects
Summary meta-analysis plot [random effects]
Kligman et al. 1979 (other)
16,00 (12,28, 19,72)
Wilhelm KP et al. 1991 (Evaporimeter)
4,00 (3,41, 4,59)
Oestmann et al. 1993 (Evaporimeter)
5,30 (5,20, 5,40)
combined
6,49 (4,60, 8,38)
0
5
10
15
20
* difference (95% confidence interval)
61
Online Resource 4. Pooled TEWL estimates
(28c) Forearm left dorsal study including 65+ year old subjects
Summary meta-analysis plot [random effects]
Wilhelm KP et al. 1991 (Evaporimeter)
3,00 (2,61, 3,39)
combined
3,00 (2,61, 3,39)
2,5
2,7
2,9
3,1
3,3
3,5
* difference (95% confidence interval)
62
Online Resource 4. Pooled TEWL estimates
(29a) Forearm right dorsal all studies
Summary meta-analysis plot [random effects]
Cua et al. 1990 (Evaporimeter)
4,10 (3,53, 4,67)
Cua et al. 1990 (Evaporimeter)
2,80 (2,64, 2,96)
Oestmann et al. 1993 (Evaporimeter)
5,30 (5,20, 5,40)
Conti et al. 1995 (Evaporimeter)
4,10 (3,47, 4,73)
Chu, Kollias 2011 (Vapometer)
6,80 (5,49, 8,11)
Chu, Kollias 2011 (Vapometer)
5,50 (4,13, 6,87)
Chu, Kollias 2011 (Vapometer)
6,00 (4,82, 7,18)
Chu, Kollias 2011 (Vapometer)
4,60 (3,82, 5,38)
combined
4,84 (3,69, 6,00)
2
4
6
8
10
* difference (95% confidence interval)
63
Online Resource 4. Pooled TEWL estimates
(29b) Forearm right dorsal studies including 18 to 64 year old subjects
Summary meta-analysis plot [random effects]
Cua et al. 1990 (Evaporimeter)
4,10 (3,53, 4,67)
Oestmann et al. 1993 (Evaporimeter)
5,30 (5,20, 5,40)
Chu, Kollias 2011 (Vapometer)
6,80 (5,49, 8,11)
Chu, Kollias 2011 (Vapometer)
5,50 (4,13, 6,87)
combined
5,27 (4,39, 6,15)
3
5
7
9
* difference (95% confidence interval)
64
Online Resource 4. Pooled TEWL estimates
(29c) Forearm right dorsal studies including 65+ year old subjects
Summary meta-analysis plot [random effects]
Cua et al. 1990 (Evaporimeter)
2,80 (2,64, 2,96)
Chu, Kollias 2011 (Vapometer)
6,00 (4,82, 7,18)
Chu, Kollias 2011 (Vapometer)
4,60 (3,82, 5,38)
combined
4,40 (2,53, 6,27)
2
4
6
8
* difference (95% confidence interval)
65
Online Resource 4. Pooled TEWL estimates
(30) Hand left back
Summary meta-analysis plot [random effects]
Winker et al. 2009 (Tewameter 210)
29,80 (28,68, 30,92)
Kleesz et al. 2012 (Tewameter 300)
12,50 (11,72, 13,28)
combined
21,15 (4,19, 38,10)
0
10
20
30
40
* difference (95% confidence interval)
66
Online Resource 4. Pooled TEWL estimates
(31a) Hand right back all studies
Summary meta-analysis plot [random effects]
Conti et al. 1995 (Evaporimeter)
12,00 (10,47, 13,53)
Barel et al. 2001 (Tewameter 210)
5,40 (5,34, 5,46)
Hachem et al. 2002 (Tewameter 210)
13,90 (12,59, 15,21)
Hachem et al. 2002 (Tewameter 210)
21,50 (19,15, 23,85)
Savic et al. 2004 (Tewameter 210)
15,20 (9,75, 20,65)
Savic et al. 2004 (Tewameter 210)
13,20 (11,28, 15,12)
Sunwoo et al. 2006a (Vapometer)
24,00 (16,38, 31,62)
Sunwoo et al. 2006a (Vapometer)
21,20 (16,18, 26,22)
Sunwoo et al. 2006b (Vapometer)
19,30 (15,54, 23,06)
Williams et al. 2009 (Evaporimeter)
8,30 (7,99, 8,61)
Winker et al. 2009 (Tewameter 210)
29,10 (28,06, 30,14)
Pinto et al. 2011 (Tewameter 300)
10,40 (8,83, 11,97)
Steiner et al. 2011 (Tewameter 300)
9,40 (6,54, 12,26)
Steiner et al. 2011(Vapometer)
9,40 (7,07, 11,73)
Kleesz et al. 2012 (Tewameter 300)
13,00 (12,29, 13,71)
combined
14,71 (11,87, 17,55)
0
6
12
18
24
30
36
* difference (95% confidence interval)
67
Online Resource 4. Pooled TEWL estimates
(31b) Hand right back studies including 18 to 64 year old subjects
Summary meta-analysis plot [random effects]
Barel et al. 2001 (Tewameter 210)
5,40 (5,34, 5,46)
Hachem et al. 2002 (Tewameter 210)
13,90 (12,59, 15,21)
Hachem et al. 2002 (Tewameter 210)
21,50 (19,15, 23,85)
Sunwoo et al. 2006b (Vapometer)
19,30 (15,54, 23,06)
Winker et al. 2009 (Tewameter 210)
29,10 (28,06, 30,14)
Pinto et al. 2011 (Tewameter 300)
10,40 (8,83, 11,97)
Kleesz et al. 2012 (Tewameter 300)
13,00 (12,29, 13,71)
combined
16,06 (9,01, 23,10)
0
6
12
18
24
30
36
* difference (95% confidence interval)
68
Online Resource 4. Pooled TEWL estimates
(32) Palm left
Summary meta-analysis plot [random effects]
Harmsze et al. 2008 (Tewameter 300)
45,80 (37,41, 54,19)
Kleesz et al. 2012 (Tewameter 300)
42,00 (40,08, 43,92)
combined
42,19 (40,32, 44,06)
37
42
47
52
57
* difference (95% confidence interval)
69
Online Resource 4. Pooled TEWL estimates
(33a) Palm right all studies
Summary meta-analysis plot [random effects]
Blichmann, Serup 1987 (Evaporimeter)
38,90 (29,98, 47,82)
Blichmann, Serup 1988 (Evaporimeter)
35,00 (29,36, 40,64)
Cua et al. 1990 (Evaporimeter)
20,70 (19,72, 21,68)
Cua et al. 1990 (Evaporimeter)
24,90 (20,94, 28,86)
Cua, Wilhelm et al. 1990 (Evaporimeter)
26,20 (19,75, 32,65)
Cua, Wilhelm et al. 1990 (Evaporimeter)
31,00 (25,30, 36,70)
Wilhelm KP et al. 1991 (Evaporimeter)
21,00 (17,08, 24,92)
Wilhelm KP et al. 1991 (Evaporimeter)
25,00 (21,08, 28,92)
Conti et al. 1995 (Evaporimeter)
53,00 (47,57, 58,43)
Tetteh et al. 2009 (Vapometer)
115,80 (99,43, 132,17)
Steiner et al. 2011 (Tewameter 300)
37,00 (26,06, 47,94)
Steiner et al. 2011(Vapometer)
28,00 (21,34, 34,66)
Kleesz et al. 2012 (Tewameter 300)
40,00 (37,90, 42,10)
combined
36,31 (29,50, 43,12)
10
40
70
100
130
160
* difference (95% confidence interval)
70
Online Resource 4. Pooled TEWL estimates
(33b) Palm right studies including 18 to 64 year old subjects
Summary meta-analysis plot [random effects]
Blichmann, Serup 1987 (Evaporimeter)
38,90 (29,98, 47,82)
Blichmann, Serup 1988 (Evaporimeter)
35,00 (29,36, 40,64)
Cua et al. 1990 (Evaporimeter)
24,90 (20,94, 28,86)
Wilhelm KP et al. 1991 (Evaporimeter)
25,00 (21,08, 28,92)
115,80 (99,43, 132,17)
Tetteh et al. 2009 (Vapometer)
Kleesz et al. 2012 (Tewameter 300)
40,00 (37,90, 42,10)
combined
43,32 (32,55, 54,09)
10
40
70
100
130
160
* difference (95% confidence interval)
71
Online Resource 4. Pooled TEWL estimates
(33c) Palm right studies including 65+ year old subjects
Summary meta-analysis plot [random effects]
Cua et al. 1990 (Evaporimeter)
20,70 (19,72, 21,68)
Wilhelm KP et al. 1991 (Evaporimeter)
21,00 (17,08, 24,92)
combined
20,72 (19,77, 21,67)
16
19
22
25
* difference (95% confidence interval)
72
Online Resource 4. Pooled TEWL estimates
(34) Chest
Summary meta-analysis plot [random effects]
10,70 (10,05, 11,35)
Barel, Clarys 1995 (Tewameter 210)
Barel, Clarys 1995 (Evaporimeter)
4,70 (2,78, 6,62)
Gardinier et al. 2009 (Tewameter 300)
9,40 (9,01, 9,79)
combined
8,61 (6,77, 10,45)
1
4
7
10
13
* difference (95% confidence interval)
73
Online Resource 4. Pooled TEWL estimates
(35a) Abdomen all studies
Summary meta-analysis plot [random effects]
Lotte et al. 1987 (Evaporimeter)
5,20 (4,85, 5,55)
Cua, Wilhelm et al. 1990 (Evaporimeter)
1,90 (1,41, 2,39)
Cua, Wilhelm et al. 1990 (Evaporimeter)
5,40 (4,73, 6,07)
Cua et al. 1990 (Evaporimeter)
4,10 (3,32, 4,88)
Cua et al. 1990 (Evaporimeter)
2,60 (2,52, 2,68)
Wilhelm KP et al. 1991 (Evaporimeter)
2,50 (1,91, 3,09)
Wilhelm KP et al. 1991 (Evaporimeter)
4,50 (3,72, 5,28)
Barel, Clarys 1995 (Evaporimeter)
4,00 (2,59, 5,41)
Barel, Clarys 1995 (Tewameter 210)
9,90 (9,02, 10,78)
Conti et al. 1995 (Evaporimeter)
4,70 (3,56, 5,84)
Koskela et al. 2009 (Vapometer)
10,00 (6,45, 13,55)
Machado et al. 2010 (Aqua Flux)
12,00 (11,24, 12,76)
combined
5,44 (3,97, 6,90)
0
5
10
15
* difference (95% confidence interval)
74
Online Resource 4. Pooled TEWL estimates
(35b) Abdomen studies including 18 to 64 year old subjects
Summary meta-analysis plot [random effects]
Cua et al. 1990 (Evaporimeter)
4,10 (3,32, 4,88)
Wilhelm KP et al. 1991 (Evaporimeter)
4,50 (3,72, 5,28)
Barel, Clarys 1995 (Evaporimeter)
4,00 (2,59, 5,41)
Barel, Clarys 1995 (Tewameter 210)
9,90 (9,02, 10,78)
Machado et al. 2010 (Aqua Flux)
12,00 (11,24, 12,76)
6,91 (3,46, 10,37)
combined
1
4
7
10
13
* difference (95% confidence interval)
75
Online Resource 4. Pooled TEWL estimates
(35c) Abdomen studies including 65+ year old subjects
Summary meta-analysis plot [random effects]
Cua et al. 1990 (Evaporimeter)
2,60 (2,52, 2,68)
Wilhelm KP et al. 1991 (Evaporimeter)
2,50 (1,91, 3,09)
combined
2,60 (2,52, 2,68)
1,9
2,4
2,9
3,4
* difference (95% confidence interval)
76
Online Resource 4. Pooled TEWL estimates
(36) Back left upper
Summary meta-analysis plot [random effects]
Antoine et al. 1989 (Evaporimeter)
8,30 (6,69, 9,91)
Kleesz et al. 2012 (Tewameter 300)
9,00 (8,29, 9,71)
combined
8,89 (8,24, 9,53)
6
7
8
9
10
* difference (95% confidence interval)
77
Online Resource 4. Pooled TEWL estimates
(37a) Back right upper all studies
Summary meta-analysis plot [random effects]
Lammintausia et al. 1987 (Evaporimeter)
3,40 (2,89, 3,91)
Berardesca, Maibach 1988b (Evaporimeter)
2,90 (2,23, 3,57)
Berardesca, Maibach 1988b (Evaporimeter)
2,70 (2,25, 3,15)
Goh et al. 1988 (Evaporimeter)
4,70 (2,80, 6,60)
Goh et al. 1988 (Evaporimeter)
4,40 (3,52, 5,28)
Antoine et al. 1989 (Evaporimeter)
7,90 (6,37, 9,43)
Cua et al. 1990 (Evaporimeter)
3,80 (3,62, 3,98)
Cua et al. 1990 (Evaporimeter)
6,40 (5,24, 7,56)
Cua, Wilhelm et al. 1990 (Evaporimeter)
3,30 (2,48, 4,12)
Cua, Wilhelm et al. 1990 (Evaporimeter)
5,60 (4,72, 6,48)
Wilhelm KP et al. 1991 (Evaporimeter)
4,00 (3,02, 4,98)
Wilhelm KP et al. 1991 (Evaporimeter)
7,00 (6,22, 7,78)
Conti et al. 1995 (Evaporimeter)
4,60 (3,80, 5,40)
Fuchs et al. 2000 (Evaporimeter)
7,00 (5,57, 8,43)
Gebhard et al. 2004 (Tewameter 210)
7,00 (6,22, 7,78)
combined
4,89 (4,19, 5,60)
0
2
4
6
8
10
* difference (95% confidence interval)
78
Online Resource 4. Pooled TEWL estimates
(37b) Back right upper studies including 18 to 64 year old subjects
Summary meta-analysis plot [random effects]
Goh et al. 1988 (Evaporimeter)
4,70 (2,80, 6,60)
Goh et al. 1988 (Evaporimeter)
4,40 (3,52, 5,28)
Antoine et al. 1989 (Evaporimeter)
7,90 (6,37, 9,43)
Cua et al. 1990 (Evaporimeter)
6,40 (5,24, 7,56)
Wilhelm KP et al. 1991 (Evaporimeter)
7,00 (6,22, 7,78)
Fuchs et al. 2000 (Evaporimeter)
7,00 (5,57, 8,43)
Gebhard et al. 2004 (Tewameter 210)
7,00 (6,22, 7,78)
combined
6,36 (5,41, 7,32)
0
2
4
6
8
10
* difference (95% confidence interval)
79
Online Resource 4. Pooled TEWL estimates
(37c) Back right upper studies including 65+ year old subjects
Summary meta-analysis plot [random effects]
Cua et al. 1990 (Evaporimeter)
3,80 (3,62, 3,98)
Wilhelm KP et al. 1991 (Evaporimeter)
4,00 (3,02, 4,98)
combined
3,81 (3,63, 3,98)
3,0
3,5
4,0
4,5
5,0
* difference (95% confidence interval)
80
Online Resource 4. Pooled TEWL estimates
(38a) Back mid all studies
Summary meta-analysis plot [random effects]
Faergemann et al. 1983 (Evaporimeter)
4,40 (3,81, 4,99)
Berardesca, Maibach 1988a (Evaporimeter)
2,70 (2,25, 3,15)
Berardesca, Maibach 1988a (Evaporimeter)
3,30 (2,73, 3,87)
Lammintausta et al. 1988 (Evaporimeter)
3,70 (3,45, 3,95)
Schlüter-Wigger, Elsner 1996 (Tewameter 210)
9,90 (9,12, 10,68)
Wigger-Alberti 1997 (Tewameter 210)
10,00 (9,61, 10,39)
Schwindt et al. 1998 (Tewameter 210)
5,50 (5,30, 5,70)
Schwindt et al. 1998 (Tewameter 210)
9,00 (8,41, 9,59)
Schliemann-Willers et al 2002 (Tewameter 210)
10,10 (9,43, 10,77)
combined
6,50 (4,76, 8,24)
1
4
7
10
13
* difference (95% confidence interval)
81
Online Resource 4. Pooled TEWL estimates
(38b) Back mid studies including 18 to 64 year old subjects
Summary meta-analysis plot [random effects]
Faergemann et al. 1983 (Evaporimeter)
4,40 (3,81, 4,99)
Schlüter-Wigger, Elsner 1996 (Tewameter 210)
9,90 (9,12, 10,68)
Wigger-Alberti 1997 (Tewameter 210)
10,00 (9,61, 10,39)
Schliemann-Willers et al 2002 (Tewameter 210)
10,10 (9,43, 10,77)
combined
8,60 (5,82, 11,37)
2
4
6
8
10
12
* difference (95% confidence interval)
82
Online Resource 4. Pooled TEWL estimates
(39) Back left lower
Summary meta-analysis plot [random effects]
Antoine et al. 1989 (Evaporimeter)
8,20 (6,06, 10,34)
combined
8,20 (6,06, 10,34)
6
7
8
9
10
11
* difference (95% confidence interval)
83
Online Resource 4. Pooled TEWL estimates
(40a) Back right lower all studies
Summary meta-analysis plot [random effects]
Antoine et al. 1989 (Evaporimeter)
8,30 (5,58, 11,02)
Cua et al. 1990 (Evaporimeter)
3,40 (3,26, 3,54)
Cua et al. 1990 (Evaporimeter)
5,40 (4,50, 6,30)
Wilhelm KP et al. 1991 (Evaporimeter)
6,00 (5,41, 6,59)
Wilhelm KP et al. 1991 (Evaporimeter)
3,50 (2,52, 4,48)
Conti et al. 1995 (Evaporimeter)
3,50 (2,30, 4,70)
Lim et al. 2008 (Tewameter 300)
10,00 (8,73, 11,27)
combined
5,59 (4,03, 7,14)
2
4
6
8
10
12
* difference (95% confidence interval)
84
Online Resource 4. Pooled TEWL estimates
(40b) Back right lower studies including 18 to 64 year old subjects
Summary meta-analysis plot [random effects]
8,30 (5,58, 11,02)
Antoine et al. 1989 (Evaporimeter)
Cua et al. 1990 (Evaporimeter)
5,40 (4,50, 6,30)
Wilhelm KP et al. 1991 (Evaporimeter)
6,00 (5,41, 6,59)
Lim et al. 2008 (Tewameter 300)
10,00 (8,73, 11,27)
combined
7,30 (5,35, 9,24)
4
6
8
10
12
* difference (95% confidence interval)
85
Online Resource 4. Pooled TEWL estimates
(40c) Back right lower studies including 65+ year old subjects
Summary meta-analysis plot [random effects]
Cua et al. 1990 (Evaporimeter)
3,40 (3,26, 3,54)
Wilhelm KP et al. 1991 (Evaporimeter)
3,50 (2,52, 4,48)
combined
3,40 (3,27, 3,54)
2,0
2,5
3,0
3,5
4,0
4,5
* difference (95% confidence interval)
86
Online Resource 4. Pooled TEWL estimates
(41) Buttock
Summary meta-analysis plot [random effects]
Conti et al. 1995 (Evaporimeter)
3,60 (2,84, 4,36)
combined
3,60 (2,84, 4,36)
2,5
2,9
3,3
3,7
4,1
4,5
* difference (95% confidence interval)
87
Online Resource 4. Pooled TEWL estimates
(42a) Thigh all studies
Summary meta-analysis plot [random effects]
Cua et al. 1990 (Evaporimeter)
3,00 (2,88, 3,12)
Cua et al. 1990 (Evaporimeter)
5,40 (4,26, 6,54)
Cua, Wilhelm et al. 1990 (Evaporimeter)
2,20 (1,65, 2,75)
Cua, Wilhelm et al. 1990 (Evaporimeter)
5,10 (3,90, 6,30)
Doucet et al. 1991 (Evaporimeter)
3,20 (3,00, 3,40)
Wilhelm KP et al. 1991 (Evaporimeter)
3,00 (2,02, 3,98)
Wilhelm KP et al. 1991 (Evaporimeter)
6,00 (5,22, 6,78)
Barel, Clarys 1995 (Tewameter 210)
9,60 (8,72, 10,48)
Barel, Clarys 1995 (Evaporimeter)
4,50 (3,09, 5,91)
Effendy et al. 1995a (Tewameter 210)
7,10 (6,53, 7,67)
Löffler et al. 1996 (Tewameter 210)
7,10 (6,53, 7,67)
combined
5,09 (4,09, 6,10)
1
3
5
7
9
11
* difference (95% confidence interval)
88
Online Resource 4. Pooled TEWL estimates
(42b) Thigh studies including 18 to 64 year old subjects
Summary meta-analysis plot [random effects]
Cua et al. 1990 (Evaporimeter)
5,40 (4,26, 6,54)
Doucet et al. 1991 (Evaporimeter)
3,20 (3,00, 3,40)
Wilhelm KP et al. 1991 (Evaporimeter)
6,00 (5,22, 6,78)
Barel, Clarys 1995 (Tewameter 210)
9,60 (8,72, 10,48)
Barel, Clarys 1995 (Evaporimeter)
4,50 (3,09, 5,91)
Effendy et al. 1995a (Tewameter 210)
7,10 (6,53, 7,67)
Löffler et al. 1996 (Tewameter 210)
7,10 (6,53, 7,67)
combined
6,13 (4,14, 8,12)
1
3
5
7
9
11
* difference (95% confidence interval)
89
Online Resource 4. Pooled TEWL estimates
(42c) Thigh studies including 65+ year old subjects
Summary meta-analysis plot [random effects]
Cua et al. 1990 (Evaporimeter)
3,00 (2,88, 3,12)
Wilhelm KP et al. 1991 (Evaporimeter)
3,00 (2,02, 3,98)
combined
3,00 (2,88, 3,12)
2,0
2,5
3,0
3,5
4,0
* difference (95% confidence interval)
90
Online Resource 4. Pooled TEWL estimates
(43a) Labia majora all studies
Summary meta-analysis plot [random effects]
Elsner et al. 1990a (Evaporimeter)
15,20 (13,22, 17,18)
Elsner et al. 1990a (Evaporimeter)
17,30 (15,69, 18,91)
Elsner et al. 1990b (Evaporimeter)
13,50 (12,38, 14,62)
Elsner et al. 1990b (Evaporimeter)
14,80 (11,86, 17,74)
Elsner, Maibach 1990c (Evaporimeter)
19,50 (16,95, 22,05)
Wilhelm D et al. 1991 (Evaporimeter)
14,90 (12,78, 17,02)
Warren et al. 2005 (Evaporimeter)
24,20 (20,67, 27,73)
combined
16,81 (14,60, 19,02)
10
15
20
25
30
* difference (95% confidence interval)
91
Online Resource 4. Pooled TEWL estimates
(43b) Labia majora studies including 18 to 64 year old subjects
Summary meta-analysis plot [random effects]
Elsner et al. 1990a (Evaporimeter)
17,30 (15,69, 18,91)
Elsner et al. 1990b (Evaporimeter)
14,80 (11,86, 17,74)
Wilhelm D et al. 1991 (Evaporimeter)
14,90 (12,78, 17,02)
Warren et al. 2005 (Evaporimeter)
24,20 (20,67, 27,73)
combined
17,59 (14,33, 20,84)
10
15
20
25
30
* difference (95% confidence interval)
92
Online Resource 4. Pooled TEWL estimates
(44) Shin
Summary meta-analysis plot [random effects]
Conti et al. 1995 (Evaporimeter)
2,80 (2,29, 3,31)
combined
2,80 (2,29, 3,31)
2,2
2,5
2,8
3,1
3,4
* difference (95% confidence interval)
93
Online Resource 4. Pooled TEWL estimates
(45a) Calf all studies
Summary meta-analysis plot [random effects]
2,60 (2,15, 3,05)
Conti et al. 1995 (Evaporimeter)
Engelke et al. 1997 (Tewameter 210)
16,00 (13,80, 18,20)
Engelke et al. 1997 (Tewameter 210)
13,70 (11,84, 15,56)
Black et al. 2000 (Evaporimeter)
8,50 (7,30, 9,70)
Black et al. 2000 (Evaporimeter)
7,00 (6,24, 7,76)
Black et al. 2000 (Evaporimeter)
6,10 (5,34, 6,86)
Kleesz et al. 2012 (Tewameter 300)
11,00 (10,82, 11,18)
combined
9,20 (5,73, 12,68)
0
5
10
15
20
* difference (95% confidence interval)
94
Online Resource 4. Pooled TEWL estimates
(45b) Calf studies including 18 to 64 year old subjects
Summary meta-analysis plot [random effects]
Engelke et al. 1997 (Tewameter 210)
16,00 (13,80, 18,20)
Black et al. 2000 (Evaporimeter)
8,50 (7,30, 9,70)
Black et al. 2000 (Evaporimeter)
7,00 (6,24, 7,76)
Black et al. 2000 (Evaporimeter)
6,10 (5,34, 6,86)
Kleesz et al. 2012 (Tewameter 300)
11,00 (10,82, 11,18)
combined
9,59 (6,94, 12,24)
5
10
15
20
* difference (95% confidence interval)
95
Online Resource 4. Pooled TEWL estimates
(46) Leg medial
Summary meta-analysis plot [random effects]
Ilzaka et al. 2012 (Vapometer)
4,50 (4,07, 4,93)
combined
4,50 (4,07, 4,93)
4,0
4,2
4,4
4,6
4,8
5,0
* difference (95% confidence interval)
96
Online Resource 4. Pooled TEWL estimates
(47a) Leg lateral all studies
Summary meta-analysis plot [random effects]
Kligman et al. 1979 (other)
12,00 (8,61, 15,39)
Kligman et al. 1979 (other)
15,00 (13,04, 16,96)
Berry et al. 1999 (Evaporimeter)
6,00 (5,02, 6,98)
Barel et al. 2001 (Tewameter 210)
5,40 (5,38, 5,42)
Tagami et al. 2002 (DermaLab5)
5,60 (5,31, 5,89)
Tagami et al. 2002 (Modell H4300)
2,80 (2,62, 2,98)
Gardinier et al. 2009 (Tewameter 300)
8,60 (5,86, 11,34)
Ilzaka et al. 2012 (Vapometer)
4,10 (3,73, 4,47)
combined
6,68 (5,48, 7,88)
1
6
11
16
21
* difference (95% confidence interval)
97
Online Resource 4. Pooled TEWL estimates
(47b) Leg lateral studies including 18 to 64 year old subjects
Summary meta-analysis plot [random effects]
Kligman et al. 1979 (other)
15,00 (13,04, 16,96)
Berry et al. 1999 (Evaporimeter)
6,00 (5,02, 6,98)
Barel et al. 2001 (Tewameter 210)
5,40 (5,38, 5,42)
Gardinier et al. 2009 (Tewameter 300)
8,60 (5,86, 11,34)
combined
8,60 (5,59, 11,61)
5
10
15
20
* difference (95% confidence interval)
98
Online Resource 4. Pooled TEWL estimates
(47c) Leg lateral studies including 65+ year old subjects
Summary meta-analysis plot [random effects]
12,00 (8,61, 15,39)
Kligman et al. 1979 (other)
4,10 (3,73, 4,47)
Ilzaka et al. 2012 (Vapometer)
combined
7,86 (0,13, 15,60)
0
4
8
12
16
* difference (95% confidence interval)
99
Online Resource 4. Pooled TEWL estimates
(48a) Ankle all studies
Summary meta-analysis plot [random effects]
Cua et al. 1990 (Evaporimeter)
4,30 (4,14, 4,46)
Cua et al. 1990 (Evaporimeter)
11,20 (7,40, 15,00)
Cua, Wilhelm et al. 1990 (Evaporimeter)
2,50 (1,87, 3,13)
Cua, Wilhelm et al. 1990 (Evaporimeter)
6,20 (4,95, 7,45)
Wilhelm KP et al. 1991 (Evaporimeter)
5,00 (4,22, 5,78)
Wilhelm KP et al. 1991 (Evaporimeter)
12,00 (9,65, 14,35)
6,03 (4,59, 7,46)
combined
0
5
10
15
* difference (95% confidence interval)
100
Online Resource 4. Pooled TEWL estimates
(48b) Ankle studies including 18 to 64 year old subjects
Summary meta-analysis plot [random effects]
Cua et al. 1990 (Evaporimeter)
11,20 (7,40, 15,00)
Wilhelm KP et al. 1991 (Evaporimeter)
12,00 (9,65, 14,35)
combined
11,78 (9,78, 13,78)
6
8
10
12
14
16
* difference (95% confidence interval)
101
Online Resource 4. Pooled TEWL estimates
(48c) Ankle studies including 65+ year old subjects
Summary meta-analysis plot [random effects]
Cua et al. 1990 (Evaporimeter)
4,30 (4,14, 4,46)
Wilhelm KP et al. 1991 (Evaporimeter)
5,00 (4,22, 5,78)
combined
4,54 (3,89, 5,19)
3,8
4,3
4,8
5,3
5,8
* difference (95% confidence interval)
102
Online Resource 4. Pooled TEWL estimates
(49a) Foot arch all studies
Summary meta-analysis plot [random effects]
Conti et al. 1995 (Evaporimeter)
21,60 (15,15, 28,05)
Tetteh et al. 2009 (Vapometer)
57,70 (49,39, 66,01)
Kleesz et al. 2012 (Tewameter 300)
44,00 (41,90, 46,10)
combined
40,97 (24,51, 57,43)
0
20
40
60
80
* difference (95% confidence interval)
103
Online Resource 4. Pooled TEWL estimates
(49b) Foot arch studies including 18 to 64 year old subjects
Summary meta-analysis plot [random effects]
Tetteh et al. 2009 (Vapometer)
57,70 (49,39, 66,01)
Kleesz et al. 2012 (Tewameter 300)
44,00 (41,90, 46,10)
combined
50,24 (36,86, 63,61)
30
40
50
60
70
* difference (95% confidence interval)
104
Online Resource 4. Pooled TEWL estimates
(50) Foot back
Summary meta-analysis plot [random effects]
Kleesz et al. 2012 (Tewameter 300)
18,00 (15,90, 20,10)
combined
18,00 (15,90, 20,10)
15
17
19
21
* difference (95% confidence interval)
105