Online Resource 2. Excluded studies
Article title:
Transepidermal water loss in young and aged healthy humans:
a systematic review and meta-analysis
Journal name:
Archives of Dermatological Research
Authors:
Jan Kottner, Andrea Lichterfeld, Ulrike Blume-Peytavi
Corresponding author:
Jan Kottner
Charité-Universitätsmedizin Berlin
Department of Dermatology and Allergy
Clinical Research Center for Hair and Skin Science
Tel +49 (0)30 450 518 218
Fax +49 (0)30 450 518 952
Email: [email protected]
1
Online Resource 2. Excluded studies
Author (year)
Reasons
Baker et al. (1967) [19]
Use of non-comparable method;
No reporting of age
No reporting of age;
No measurements without intervention
Use of non-comparable method;
No reporting of age
Use of non-comparable method
No TEWL baseline values reported
No reporting of age
Animal study
Subject characteristics not reported;
Use of non-comparable method
Report unavailable
No reporting of ages;
Unclear reporting of anatomic sites
Use of non-comparable method
No TEWL baseline values reported
No TEWL baseline values reported
Reporting of results unclear;
No TEWL baseline values reported
No TEWL baseline values reported
No TEWL baseline values reported
No TEWL baseline values reported
No reporting about the subjects
No TEWL baseline values reported
No TEWL baseline values reported
No TEWL baseline values reported
Spread parameters are missing
Spread parameters are missing
Spread parameters are missing
No reporting about the subject
No TEWL baseline values reported
Spread parameters are missing
Reporting of results unclear
Spread parameters are missing
No TEWL measurements
No TEWL baseline values reported
No TEWL baseline values reported
Spread parameters are missing
No TEWL baseline values reported
No TEWL baseline values reported
Spread parameters are missing
Spread parameters are missing
Spread parameters are missing
No TEWL baseline values reported
No TEWL baseline values reported
Spread parameters are missing
Animal study
No TEWL baseline values reported
No TEWL baseline values reported
No TEWL measurements
Subjects < 18 years included
Spread parameters are missing
No TEWL baseline values reported
No TEWL baseline values reported
No age-dates reported
Spread parameters are missing
No TEWL baseline values reported
Reporting of results unclear
Spread parameters are missing
Spread parameters are missing
Bettley et al. (1967) [24]
Shahidullah et al. (1969) [189]
Berube et al. (1971) [23]
Grice et al. (1971) [87]
Grice et al. (1972) [86]
Hattingh (1972a) [93]
Hattingh (1972b) [94]
Nilsson (1977)
Aly et al. (1978) [13]
Britz, Maibach (1979) [32]
Mathias et al. (1981) [145]
Frödin, Skogh (1984) [70]
Leveque et al. (1984) [134]
Kligman et al. (1986) [115]
Murahata et al. (1986) [153]
Takahashi, Marks (1986) [196]
Van Neste et al. (1987) [209]
Arend et al. (1988) [50]
Freeman et al. (1988) [68]
Frödin et al. (1988) [69]
Agner et al. (1989) [10]
Agner, Serup (1989a) [8]
Agner, Serup (1989b) [7]
Jemec et al. (1989) [105]
Pinnagoda et al. (1989) [161]
Tupker et al. (1989) [206]
Agner (1990) [4]
Agner, Serup (1990a) [6]
Agner, Serup (1990b) [9]
Berardesca, Maibach (1990) [22]
Elsner et al. (1990) [60]
Queille-Roussel et al. (1990) [166]
Tupker et al. (1990b) [207]
Wilhelm, K. et al. (1990a) [215]
Yamamura et al. (1990) [222]
Agner (1991a) [1]
Agner (1991b) [3]
Agner et al. (1991c) [5]
Gabard (1991) [74]
Agner (1992) [2]
Fartasch, Diepgen (1992) [64]
Prokosch (1992) [164]
Seidenari, Di Nardo (1992) [185]
Serup (1992) [188]
Hashimoto-Kumasaka et al. (1993) [92]
Lavrijsen et al. (1993) [129]
Leveque et al. (1993) [135]
Andersen et al. (1994) [15]
Denda et al. (1994) [51]
Elsner (1994) [57]
Lavrijsen et al. (1994) [128]
Öhman et al. (1994) [157]
Pierard et al. (1994) [159]
Widmer et al. (1994) [213]
Effendy et al. (1995b) [56]
2
Online Resource 2. Excluded studies
Graves et al. (1995) [84]
Hannuksela et al. (1995) [89]
Johansen et al. (1995) [106]
Levy et al. (1995) [138]
Pierard-Franchimont et al. (1995b) [160]
Ramsing et al. (1995) [168]
Schürer et al. (1995) [182]
Seidenari et al. (1995) [186]
Di Nardo (1996a) [52]
Di Nardo (1996b) [54]
Ghadially et al. (1996) [80]
Hollmann et al. (1996) [98]
Kalia et al. (1996) [108]
Le et al. (1996) [131]
Moss (1996) [149]
Ramsing, Agner et al. (1996) [169]
Shriner , Maibach (1996) [191]
Treffel, Gabard (1996) [204]
Ale et al. (1997) [12]
Berardesca et al. (1997) [21]
Boelsma et al. (1997) [28]
Clarys et al.(1997) [41]
Coulomb et al.(1997) [42]
Le et al. (1997) [132]
Lee et al. (1997) [133]
Quan et al. (1997) [165]
Reed et al. (1997) [172]
Sheu et al. (1997) [190]
Di Nardo et al. (1998) [53]
Elsner et al. (1998) [59]
Fartasch et al. (1998) [65]
Gabard, Treffel (1998) [75]
Hildebrandt et al. (1998) [97]
Kieffer, Efsen (1998) [112]
Muizzuddin et al. (1998) [150]
Müller-Decker et al. (1998) [152]
Rodrigues,Pereira (1998) [173]
Schwindt et al. (1998) [183]
Tanaka et al (1998) [197]
Yosipovitch et al. (1998) [227]
Zhai et al. (1998) [230]
English et al. (1999) [62]
Gehring et al. (1999) [78]
Held et al. (1999) [96]
Held, Jorgensen (1999) [95]
Kawasaki et al. (1999) [111]
Loden et al. (1999) [139]
Löffler, Effendy (1999) [142]
Norlen et al. (1999) [154]
Rodrigues et al. (1999) [174]
Schnetz et al. (1999) [180]
Smith (1999) [192]
Brasch et al. (2000) [31]
Choi et al. (2000) [39]
Tanno et al. (2000) [198]
Winnefeld et al. (2000) [218]
Bashir et al. (2001) [20]
Gehring, Gloor (2001) [79]
Lübbe et al. (2001) [143]
Levin, Maibach (2001) [137]
No comparative method;
Values are not clearly reported
No TEWL baseline values reported
Spread parameters are missing
No TEWL measured before intervention
Reporting of results unclear;
No TEWL measured before intervention
Spread parameters are missing
No healthy volunteers;
Age is not clearly reported
No healthy volunteers
No TEWL baseline values reported
TEWL values not reported
No reporting of age
No healthy volunteers
No TEWL baseline values reported
No reporting of anatomic sites
No TEWL baseline values reported
Spread parameters are missing
Spread parameters are missing
No TEWL baseline values reported
No TEWL baseline values reported
Spread parameters are missing
TEWL values are not in g/m²/h reported
TEWL baseline values are unclear reported
No TEWL baseline values reported
No reporting of anatomic sites;
No TEWL baseline values reported
Reporting of results unclear
No TEWL baseline values reported
Spread parameters are missing
No healthy volunteers
TEWL Values are not clearly reported
Spread parameters are missing
No TEWL baseline values reported
No reporting of age
Spread parameters are missing
Spread parameters are missing
TEWL Values are not clearly reported
Measurements in vitro
No TEWL baseline values reported
No TEWL baseline values reported
Spread parameters are missing
Spread parameters are missing
No TEWL baseline values reported
No TEWL baseline values reported
No TEWL baseline values reported;
Subjects are not healthy
Spread parameters are missing
Spread parameters are missing
TEWL values: no localization given
Subjects are not healthy
Age groups can not clearly separated
No TEWL baseline values reported
No reporting of age
Spread parameters are missing
No TEWL baseline values reported
No TEWL measured before intervention
Spread parameters are missing
Measurements in vitro
No reporting of age
Spread parameters are missing
No TEWL baseline values reported
Spread parameters are missing
No TEWL baseline values reported
3
Online Resource 2. Excluded studies
Le Fur at al. (2001) [130]
Presto et al. (2001) [163]
Schmuth et al. (2001) [179]
Tagami et al. (2001) [195]
Aramaki et al (2002) [17]
De Paepe et al. (2002) [49]
Elsner et al. (2002) [58]
Fuchs et al. (2002) [71]
Gioia, Celleno (2002) [81]
Kramer et al. (2002) [122]
Kucharekova et al. (2002) [124]
Leveque et al. (2002) [136]
Löffler et al. (2002) [140]
Watkinson et al (2002) [211]
Wynne et al. (2002) [220]
Gasser et al. (2003) [77]
Klotz et al. (2003) [116]
Kobayashi et al. (2003) [117]
Kucharekova et al. (2003) [123]
Laudanska et al. (2003) [127]
Malminen et al. (2003) [144]
Morgan et al. (2003) [148]
Muizzuddin et al. (2003) [151]
Nuutinen et al. (2003a) [155]
Nuutinen et al. (2003b) [156]
Rodrigues et al. (2003) [175]
Rosado, Rodrigues (2003) [178]
Yoshizawa et al. (2003) [224]
Andersen et al. (2004) [14]
Arbogast et al. (2004) [18]
Bock et al. (2004) [26]
Gloor et al. (2004a) [82]
Gloor et al. (2004b) [83]
Grimes et al. (2004) [88]
Kobayashi, Tagami (2004a) [118]
Löffler et al. (2004) [141]
Pelchrzim et al. (2004) [158]
Van Kemenade et al. (2004) [208]
Yosipovitch et al. (2004) [226]
Branco et al. (2005) [30]
Korinth et al. (2005) [120]
Pinto, Rodrigues (2005) [162]
Rosado et al. (2005) [177]
Schürer et al. (2005) [181]
Teichmann et al. (2005) [199]
Tokumura et al. (2005) [200]
Zhai et al. (2005) [228]
Fuchs et al. (2006) [72]
Houben et al. (2006) [100]
Huss-Marp et al. (2006) [102]
Mirza et al. (2006) [147]
Tokumura et al. (2006) [201]
Wong et al. (2006) [219]
Bock et al. (2007) [27]
Buraczewska et al. (2007a) [36]
Buraczewska et al. (2007b) [35]
De Jongh et al. (2007) [48]
Faurschou et al. (2007) [66]
Jacobson et al. (2007) [104]
Kawai et al. (2007) [110]
Ramalho et al. (2007) [167]
Sedov et al. (2007) [184]
Törmä et al. (2007) [202]
Yagi et al. (2007) [221]
No TEWL baseline values reported
Spread parameters are missing
Subjects are not healthy
Measurements in vitro
Spread parameters are missing
No TEWL baseline values reported
No TEWL baseline values reported
No TEWL baseline values reported
Description of theoretical model;
No demographics reported
Volunteers are not healthy
Spread parameters are missing
Spread parameters are missing
Spread parameters are missing
Spread parameters are missing
No reporting of age
No TEWL baseline values reported
No TEWL baseline values reported
No human TEWL values reported, only animal
No test area is described
TEWL instrument not specified
Spread parameters are missing
Spread parameters are missing
No TEWL baseline values reported
Description of theoretical model and methods
Subjects <18 years included
No TEWL baseline values reported
No TEWL baseline values reported
No TEWL baseline values reported
Spread parameters are missing
No reporting of age
No TEWL baseline values reported
No TEWL baseline values reported
No TEWL baseline values reported
Spread parameters are missing
Spread parameters are missing
No TEWL baseline values reported
Subjects are not healthy
No TEWL baseline values reported
No reporting of age
Spread parameters are missing
Spread parameters are missing
No TEWL baseline values reported
No TEWL baseline values reported
No TEWL baseline values reported
Spread parameters are missing
Spread parameters are missing
No TEWL baseline values reported
No TEWL baseline values reported
No TEWL baseline values reported
Spread parameters are missing
Spread parameters are missing
No TEWL baseline values reported
No TEWL baseline values reported
Spread parameters are missing
Spread parameters are missing
No TEWL baseline values reported
No TEWL baseline values reported
No TEWL baseline values reported
No TEWL baseline values reported
No TEWL baseline values reported
No TEWL baseline values reported
Subjects are not healthy
Measurements in vitro
No TEWL baseline values reported
4
Online Resource 2. Excluded studies
Yosipovitch et al. (2007) [225]
Zhai et al. (2007) [229]
Caisey et al. (2008) [37]
Chang et al. (2008) [38]
Cravello, Ferri (2008) [43]
Engel et al. (2008) [61]
Gaspar et al. (2008) [76]
Grether-Beck et al. (2008) [85]
Houben et al. (2008) [99]
Kobayashi et al. (2008) [119]
Kowatzki et al. (2008) [121]
Tronnier et al. (2008) [205]
Agthe et al. (2009) [11]
Boncheva et al. (2009) [29]
Buraczewska et al. (2009a) [34]
Buraczewska et al. (2009b) [33]
Davoudi et al. (2009) [47]
Farahmand et al. (2009) [63]
Haq et al. (2009) [90]
Hashiguchi et al. (2009) [91]
Iida et al. (2009) [103]
Lange-Asschenfeldt et al. (2009) [125]
Mayrovitz et al. (2009) [146]
Rosado et al. (2009) [176]
Seirafi et al. (2009) [187]
Song et al. (2009) [193]
Sorensen et al. (2009) [194]
Wetzky et al. (2009) [212]
Wiedersberg et al. (2009) [214]
Angelova-Fischer (2010) [16]
Ciampi et al. (2010) [40]
Czaika et al. (2010) [44]
Davis et al. (2010) [46]
Du Plessis et al. (2010) [55]
Johnsen et al. (2010) [107]
Kim et al. (2010) [113]
Tran et al. (2010) [203]
Visscher et al. (2010) [210]
Williams et al. (2010) [217]
Blaak et al. (2011) [25]
Kawai et al. (2011) [109]
Larson (2011) [126]
Rasul, Akhtar (2011) [170]
Ravichandran et al. (2011) [171]
Williams et al. (2011) [216]
Darlenski, Fluhr (2012) [45]
Firooz et al. (2012) [67]
Furue et al. (2012) [73]
Hui et al. (2012) [101]
Kircik (2012) [114]
Yamashita et al. (2012) [223]
No TEWL baseline values reported
No TEWL baseline values reported
Spread parameters are missing
No TEWL baseline values reported
No TEWL baseline values reported
No TEWL baseline values reported
No TEWL baseline values reported
No TEWL baseline values reported
No TEWL baseline values reported
No TEWL baseline values reported
Spread parameters are missing
No reporting of age
No reporting of age
No TEWL baseline values reported
Spread parameters are missing
No TEWL instrument reported
Spread parameters are missing
Spread parameters are missing
No TEWL baseline values reported
No TEWL baseline values reported
No TEWL baseline values reported
No TEWL baseline values reported
No TEWL baseline values reported
No TEWL baseline values reported
Subjects <18 years included
Spread parameters are missing
No TEWL baseline values reported
Subjects <18 years included
No TEWL baseline values reported
No reporting of age
Measurements in vitro
No TEWL baseline values reported
No reporting of age
No reporting of age;
No TEWL baseline values reported
No TEWL baseline values reported
No TEWL baseline values reported
Spread parameters are missing
No reporting of age
Age groups can not clearly separated
Spread parameters are missing
No TEWL baseline values reported
No information about the volunteers
Age is not clearly reported;
TEWL values only with intervention
No TEWL baseline values clearly reported
Subjects <18 years included
Measurements only in infants
TEWL values reported without location;
Contains the excluded age
Spread parameters are missing
Measurements in vitro
Subjects <18 years included
Spread parameters are missing
5
Online Resource 2. Excluded studies
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
12.
13.
14.
15.
16.
17.
18.
19.
20.
21.
22.
23.
24.
25.
Agner T (1991) Basal transepidermal water loss, skin thickness, skin blood flow and skin
colour in relation to sodium-lauryl-sulphate-induced irritation in normal skin. Contact
Dermatitis 25:108-114
Agner T (1992) An experimental study of irritant effects of urea in different vehicles. Acta
Derm Venereol Suppl 177:44-46
Agner T (1991) Skin susceptibility in uninvolved skin of hand eczema patients and healthy
controls. Br J Dermatol 125:140-146
Agner T (1990) Susceptibility of atopic dermatitis patients to irritant dermatitis caused by
sodium lauryl sulphate. Acta Derm Venereol 71:296-300
Agner T, Damm P, Skouby SO (1991) Menstrual cycle and skin reactivity. J Am Acad
Dermatol 24:566-570
Agner T, Serup J (1990) Individual and instrumental variations in irritant patch-test
reactions--clinical evaluation and quantification by bioengineering methods. Clin Exp
Dermatol 15:29-33
Agner T, Serup J (1989) Seasonal variation of skin resistance to irritants. Br J Dermatol
121:323-328
Agner T, Serup J (1989) Skin reactions to irritants assessed by non-invasive bioengineering
methods. Contact Dermatitis 20:352-359
Agner T, Serup J (1990) Sodium lauryl sulphate for irritant patch testing--a dose-response
study using bioengineering methods for determination of skin irritation. J Invest Dermatol
95:543-547
Agner T, Serup J, Handlos V et al. (1989) Different skin irritation abilities of different
qualities of sodium lauryl sulphate. Contact Dermatitis 21:184-188
Agthe N, Terho K, Kurvinen T et al. (2009) Microbiological efficacy and tolerability of a new,
non-alcohol-based hand disinfectant. Infect Control Hosp Epidemiol 30:685-690
Ale SI, Laugier JP, Maibach HI (1997) Differential irritant skin responses to tandem
application of topical retinoic acid and sodium lauryl sulphate: II. Effect of time between first
and second exposure. Br J Dermatol 137:226-233
Aly R, Shirley C, Cunico B et al. (1978) Effect of prolonged occlusion on the microbial flora,
pH, carbon dioxide and transepidermal water loss on human skin. J Invest Dermatol 71:378381
Andersen F (2004) Effi cacy of an Aluminum Oxide Scrub Cream in the Treatment of Xerotic
Skin of the Elderly. Exog Dermatol 3:30-34
Andersen PH, Bucher AP, Saeed I et al. (1994) Faecal enzymes: in vivo human skin
irritation. Contact Dermatitis 30:152-158
Angelova-Fischer I, Fernandez IM, Donnadieu MH et al. (2010) Injury to the stratum
corneum induces in vivo expression of human thymic stromal lymphopoietin in the
epidermis. J Invest Dermatol 130:2505-2507
Aramaki J, Kawana S, Effendy I et al. (2002) Differences of skin irritation between Japanese
and European women. Br J Dermatol 146:1052-1056
Arbogast JW, Fendler EJ, Hammond BS et al. (2004) Effectiveness of a hand care regimen
with moisturizer in manufacturing facilities where workers are prone to occupational irritant
dermatitis. Dermatitis 15:10-17
Baker H, Kligman AM (1967) Measurement of transepidermal water loss by electrical
hygrometry. Instrumentation and responses to physical and chemical insults. Arch Dermatol
96:441-452
Bashir SJ, Chew AL, Anigbogu A et al. (2001) Physical and physiological effects of stratum
corneum tape stripping. Skin Res Technol 7:40-48
Berardesca E, Distante F, Vignoli GP et al. (1997) Alpha hydroxyacids modulate stratum
corneum barrier function. Br J Dermatol 137:934-938
Berardesca E, Maibach HI (1990) Transepidermal water loss and skin surface hydration in
the non invasive assessment of stratum corneum function. Dermatos Ber Umwelt 38:50-53
Berube GR, Messinge.M, Berdick M (1971) Measurement in-Vivo of Transepidermal
Moisture Loss. J Soc Cosmet Chem 22:361-&
Bettley FR, Grice KA (1967) The influence of ambient humidity on transepidermal water
loss. Br J Dermatol 79:575-581
Blaak J, Luttje D, John SM et al. (2011) Irritability of the skin barrier: A comparison of
chronologically aged and photo-aged skin in elderly and young adults. Eur Geriatr Med
2:208-211
6
Online Resource 2. Excluded studies
26.
27.
28.
29.
30.
31.
32.
33.
34.
35.
36.
37.
38.
39.
40.
41.
42.
43.
44.
45.
46.
47.
48.
49.
Bock M, Schurer NY, Schwanitz HJ (2004) Effects of CO2-enriched water on barrier
recovery. Arch Dermatol 296:163-168
Bock M, Wulfhorst B, John SM (2007) Site variations in susceptibility to SLS. Contact
Dermatitis 57:94-96
Boelsma E, Tanojo H, Bodde HE et al. (1997) An in vivo-In vitro study of the use of a human
skin equivalent for irritancy screening of fatty acids. Toxicol In Vitro 11:365-376
Boncheva M, De Sterke J, Caspers PJ et al. (2009) Depth profiling of Stratum corneum
hydration in vivo: a comparison between conductance and confocal Raman spectroscopic
measurements. Exp Dermatol 18:870-876
Branco N, Lee I, Zhai H et al. (2005) Long-term repetitive sodium lauryl sulfate-induced
irritation of the skin: an in vivo study. Contact Dermatitis 53:278-284
Brasch J, Huttemann M, Proksch E (2000) Iontophoresis of nickel elicits a delayed
cutaneous response in sensitized individuals that is similar to an allergic patch test reaction.
Contact Dermatitis 42:36-41
Britz M, Maibach H (1979) Human labia majora skin: transepidermal water loss in vivo. Acta
Derm Venereol Suppl 59:23-25
Buraczewska I, Berne B, Lindberg M et al. (2009) Long-term treatment with moisturizers
affects the mRNA levels of genes involved in keratinocyte differentiation and desquamation.
Arch Dermatol Res 301:175-181
Buraczewska I, Berne B, Lindberg M et al. (2009) Moisturizers change the mRNA
expression of enzymes synthesizing skin barrier lipids. Arch Dermatol Res 301:587-594
Buraczewska I, Berne B, Lindberg M et al. (2007) Changes in skin barrier function following
long-term treatment with moisturizers, a randomized controlled trial. Br J Dermatol 156:492498
Buraczewska I, Brostrom U, Loden M (2007) Artificial reduction in transepidermal water loss
improves skin barrier function. Br J Dermatol 157:82-86
Caisey L, Gubanova E, Camus C et al. (2008) Influence of age and hormone replacement
therapy on the functional properties of the lips. Skin Res Technol 14:220-225
Chang MJ, Huang HC, Chang HC et al. (2008) Cosmetic formulations containing
Lithospermum erythrorhizon root extract show moisturizing effects on human skin. Arch
Dermatol 300:317-323
Choi JM, Lee JY, Cho BK (2000) Chronic irritant contact dermatitis: recovery time in man.
Contact Dermatitis 42:264-269
Ciampi E, Van Ginkel M, Mcdonald PJ et al. (2011) Dynamic in vivo mapping of model
moisturiser ingress into human skin by GARfield MRI. NMR Biomed 24:135-144
Clarys P, Manou I, Barel AO (1997) Influence of temperature on irritation in the hand
forearm immersion test. Contact Dermatitis 36:240-243
Coulomb B, Friteau L, Dubertret L (1997) Biafine applied on human epidermal wounds is
chemotactic for macrophages and increases the IL-1/IL-6 ratio. Skin Pharmacol 10:281-287
Cravello B, Ferri A (2008) Relationships between skin properties and environmental
parameters. Skin Res Technol 14:180-186
Czaika V, Alborova A, Richter H et al. (2012) Comparison of Transepidermal Water Loss
and Laser Scanning Microscopy Measurements to Assess Their Value in the
Characterization of Cutaneous Barrier Defects. Skin Pharmacol Physiol 25:39-46
Darlenski R, Fluhr JW (2012) Influence of skin type, race, sex, and anatomic location on
epidermal barrier function. Clin Dermatol 30:269-273
Davis JA, Visscher MO, Wickett RR et al. (2010) Influence of tumour necrosis factor-alpha
polymorphism-308 and atopy on irritant contact dermatitis in healthcare workers. Contact
Dermatitis 63:320-332
Davoudi SM, Keshavarz S, Sadr B et al. (2009) Skin hydration and transepidermal water
loss in patients with a history of sulfur mustard contact: a case-control study. J Eur Acad
Dermatol Venereol 23:940-944
De Jongh CM, Verberk MM, Spiekstra SW et al. (2007) Cytokines at different stratum
corneum levels in normal and sodium lauryl sulphate-irritated skin. Skin Res Technol
13:390-398
De Paepe K, Hachem JP, Vanpee E et al. (2002) Effect of rice starch as a bath additive on
the barrier function of healthy but SLS-damaged skin and skin of atopic patients. Acta Derm
Venereol 82:184-186
7
Online Resource 2. Excluded studies
50.
51.
52.
53.
54.
55.
56.
57.
58.
59.
60.
61.
62.
63.
64.
65.
66.
67.
68.
69.
70.
71.
72.
Den Arend JaC, De Haan AFJ, Malten KE (1988) Short Communications, seasonal
transepidermal water loss and impedance of forearm skin in atopics and non-atopics.
Contact Dermatitis 19:376-390
Denda M, Koyama J, Namba R et al. (1994) Stratum-Corneum Lipid Morphology and
Transepidermal Water-Loss in Normal Skin and Surfactant-Induced Scaly Skin. Arch
Dermatol Res 286:41-46
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15