DOROTHEA K. THOMPSON, PH.D. Campbell University College of Pharmacy & Health Sciences Department of Pharmaceutical Sciences P.O. Box 1090, Buies Creek, NC 27506 910-893-7463 (Phone) • [email protected] (Email) PROFESSIONAL APPOINTMENTS AND EXPERIENCE CAMPBELL UNIVERSITY, COLLEGE OF PHARMACY & HEALTH SCIENCES (BUIES CREEK, NC) Associate Professor of Medical Microbiology & Immunology, January 2015 – present Department of Pharmaceutical Sciences Faculty instructor for PHAR 310, Immunology (3 credit hours) Faculty instructor for PHAR 312, Medical Microbiology (4 credit hours) MICROBIAL INSIGHTS, INC. (KNOXVILLE, TN) Scientific Consultant, June 11, 2014 – present Microbial Insights, Inc., is a biotechnology company that specializes in the development and application of molecular-based biological tools (e.g., qPCR, QuantArrays, Next-Generation Sequencing) to characterize and quantify microbial communities impacting environmental remediation, microbially influenced corrosion, and contaminant source tracking. My primary consultant responsibilities include interpreting and analyzing technical data, preparing technical reports, and providing guidance and advice in research grant development for Microbial Insights. NELSON MULLINS RILEY & SCARBOROUGH, LLP (NASHVILLE, TN) E-Discovery Contractor, Beacon Hill Staffing Group, LLC. Projects include the following: PATENT INFRINGEMENT PROJECT (01/16/2014 – 04/18/2014): Provided e-discovery and litigation support for a major biopharmaceutical patent infringement case. Coded documents for responsiveness, privilege, redaction, and significant issue coding using review platform ClarVergence. Identified key documents of relevance to litigation. HEALTHCARE ARBITRATION PROJECT (06/17/2014 – 06/19/2014): Provided e-discovery and litigation support for an arbitration case involving a healthcare insurance company. TRADE SECRETS VIOLATION PROJECT (06/23/2014 – 09/03/2014): Provided e-discovery and litigation support for a federal case involving pharmaceutical trade secrets violations. Promoted to quality control review of documents. LUEDEKA NEELY GROUP, P.C. (KNOXVILLE, TN) Technology Advisor in the Life Sciences, Aug. 2011 – May 2013 Conducted legal research and prior art searches; reviewed scientific literature and advised counsel on technical matters in biotechnology and the life sciences. Prosecuted patents including preparation of claim amendments, legal arguments, and appeal briefs. Drafted client letters outlining proposed strategies to advance patent prosecution. Prosecuted to allowance various pharmaceutical inventions for Sandoz, Inc., including vancomycin hydrochloride, rosuvastatin calcium, drospirenone composition for ovulation inhibition, a storage method for non-glycosylated recombinant human G-CSF, and a process for preparing immunomodulator glatiramer acetate. Achieved issuance of the following representative U.S. patents: 8,053,444 B2; 8,354,530 B2; 8,435,938 B2; 8,449,873 B2; and 8,475,838 B2. Registered to practice before the U.S. Patent and Trademark Office (Registration No. 70,974). D. K. Thompson, Ph.D. Page 2 CENTER FOR ENVIRONMENTAL BIOTECHNOLOGY, UNIVERSITY OF TENNESSEE (KNOXVILLE, TN) Research Scientist II, Aug. 2009 – Feb. 2011 Developed and managed a U.S. Department of Energy (DOE)-funded project on the phylogenetics and metaproteomics of microbial communities in heavy metal-contaminated soils. Prepared scientific & technical reports to the DOE. PURDUE UNIVERSITY, DEPARTMENT OF BIOLOGICAL SCIENCES (WEST LAFAYETTE, IN) Assistant Professor of Microbiology & Principal Investigator, Oct. 2005 – July 2009 Procured approximately $2.7M in total federal funding by competing successfully for DOE and NIHNIEHS R01 grants. Established, managed, and funded a research laboratory focused on the molecular mechanisms underlying microbial stress responses and two-component signal transduction systems. Collaborated with biospectroscopists to develop functionalized nanoprobes for single-cell mapping of subcellular metal bioreduction sites. Departmental and University Service: Internal Executive Committee, Purdue Center for the Environment (2006, 2008); Graduate Admissions and Recruiting Committee, Department of Biological Sciences (2007, 2008); Undergraduate Studies Committee (2008-09); Biofuels Faculty Candidate Search Committee (200708). Mentorship Activities and Involvement in Graduate Research Program: Major Advisor for Kristene Henne (w/ A. Konopka) (PhD, 2007), Irina Mugerfeld (MS, 2008), Wei Wei (MS, 2008), Stephanie Thieman; Chairperson, Ph.D. Examining Committee, for Rachael Beard, Brittany Gasper; Thesis Committee Member for Weimin Chen (MS, 2007) and Eric Warrick (MS, 2008); Undergraduate and HHMI (Howard Hughes Medical Internship) Mentor for Misha Nazareno (2006, HHMI summer intern), Brittany Law (2007, HHMI summer intern), Matt Rudisill (2007 & 2008, HHMI summer intern), and Andrea McCarthy. OAK RIDGE NATIONAL LABORATORY, ENVIRONMENTAL SCIENCES DIVISION (OAK RIDGE, TN) Group Leader (Microbial Ecology & Functional Genomics) and Staff Research Scientist, Oct. 2004 – Sept. 2005 Provided leadership in budget development, resource management, and strategic planning for a group of approximately 25 scientists. Conceived and directed DOE-funded research that combined transcriptomics, proteomics, and computational approaches in order to elucidate the molecular mechanisms underlying metal reduction by microorganisms and cellular responses to heavy metal stress. Evaluated performance of staff and assisted with recruitment of staff scientists. Procured an Oak Ridge National Laboratory Seed Money Fund award to probe molecular interactions between bacterial cells and heavy metals using atomic force microscopy and other live cell imaging technologies. R&D Associate Staff Scientist, Oct. 2002 – Sept. 2005 Developed and executed an $825K DOE grant to study the molecular basis of bacterial metal reduction. Characterized the bacterial molecular response to metal stress using complementary genomic profiling and differential proteomics based on multidimensional HPLC-MS/MS. Co-authored and edited the book Microbial Functional Genomics. Research Assistant Professor, joint position with Michigan State University, Oct. 2001 – Sept.2002 Contributed to the development and writing of several Genomes To Life (GTL) federal grants. Conducted research on gene expression regulation using mutagenesis and DNA microarray techniques. Prepared an invention disclosure for a novel microarray format containing whole-genome probes. Postdoctoral Research Associate, Dec. 1999 – Sept. 2001 Identified gene candidates under the control of the ferric iron responsive regulon using targeted gene mutagenesis and DNA microarray hybridization. D. K. Thompson, Ph.D. Page 3 U.S. FOOD AND DRUG ADMINISTRATION, DIVISION OF BACTERIAL PARASITIC AND ALLERGENIC PRODUCTS, CENTER FOR BIOLOGICS EVALUATION AND RESEARCH (BETHESDA, MD) Oak Ridge Institute for Science and Education (ORISE) Fellow, Feb. 1998 – Nov. 1999 Developed and applied a genotyping system for pathogenic Neisseria gonorrhoeae based on biotinylated oligonucleotide probes to porin gene variable regions. Evaluated the immunogenicity of synthetic peptide vaccines comprising cyclic, lipid-tailed peptide loops incorporated into liposomes. COLLEGE TEACHING EXPERIENCE PHAR 310 (Immunology), Department of Pharmaceutical Sciences, Campbell University: Spring 2015 BIOL 438 (General Microbiology), Department of Biological Sciences, Purdue University: Fall 2006, Fall 2007, and Fall 2008 (Faculty Instructor). Teaching modules included Structure and Function of Bacteria & Archaea (Structure, Composition, and Cell Function); Cell Growth and Principles of Energy Generation; Basic Genetics (DNA Replication, Transcription, and Protein Synthesis); Regulation of Gene Expression; Genetic Exchange; Microbial Evolution and Diversity; Microbial Diseases of Humans; Human Host-Microbe Interaction; Modes of Transmission of Infectious Diseases; and Antibiotic Production & Mechanisms of Action. BIOL 663 (Seminar Methods & Professional Development), Department of Biological Sciences, Purdue University: Spring 2008, Spring 2009 (Faculty Instructor). Graduate students were instructed on how to create and deliver an effective professional seminar. BIOL 696P (Prokaryotes Seminar), Department of Biological Sciences, Purdue University: Spring 2008 (Faculty Instructor). Graduate students were required to give a seminar critiquing original research papers in prokaryotic biology, and the seminars were discussed in class. MICRO 521 (Introductory Microbiology Laboratory), Department of Microbiology, Ohio State University: Spring 1993 and Spring 1995 (Graduate Teaching Associate). MICRO 581 (Microbial Genetics), Department of Microbiology, Ohio State University: 1 semester (Graduate Teaching Associate). BIOL 101 (Introductory Biology), Department of Evolution, Ecology and Organismal Biology, Ohio State University: Fall 1992 (Graduate Teaching Associate). Howard Hughes Scholars Institute in Genetics, Department of Biology, Pennsylvania State University: summer 1990 (Teaching Assistant). GRANTS AWARDED WITHIN PAST TEN YEARS Chemical Mapping of Chromate Uptake, Localization, and Reduction in Remediating Bacteria Using SurfaceEnhanced Raman Scattering Substrates. Joseph Irudayaraj (PI) and Dorothea K. Thompson (co-PI), $898,749 total, NIH-NIEHS R01. Project Period: 12/01/2008-11/30/2011. Optimization and Directed, Natural Evolution of Biologically-Mediated Chromate Reduction in Subsurface Soil Microcosms. Dorothea K. Thompson (PI) and Robert L. Hettich (co-PI). $1,815K total, DOE/BER-ERSP (Environmental Remediation Sciences Program). Project Period: 03/15/2007-03/14/2010. Elucidating the Molecular Basis and Regulation of Chromium(VI) Reduction by Shewanella oneidensis MR-1 and Resistance to Metal Toxicity Using Integrated Biochemical, Genomics and Proteomic Approaches. Dorothea K. Thompson (PI) and Robert L. Hettich (co-PI), $825K total, DOE/BER-NABIR (Natural and Accelerated Bioremediation Research Program). Project Period: 2003-2006. D. K. Thompson, Ph.D. Page 4 Using Live Cell Imaging Technologies to Probe Molecular Interactions between Bacterial Cells and Heavy Metals. Dorothea K. Thompson (PI), $125,000 total, Oak Ridge National Laboratory Seed Money Fund. Project Period: 2004-2005. SCIENTIFIC PUBLICATIONS Books Zhou, J., D. K. Thompson, Y. Xu, and J. M. Tiedje. 2004. Microbial Functional Genomics. John Wiley & Sons, Inc., Hoboken, NJ. (Translated in Chinese). Book Chapters 1. Wan, X.-F., and D. K. Thompson. 2009. High-throughput technologies and functional genomics, p. 67-113. In Fu, P., and S. Panke (ed.), Systems Biology and Synthetic Biology, John Wiley & Sons, Inc., Hoboken, NJ. 2. Zhou, J., and D. K. Thompson. 2004. Microarray Technology and Applications in Environmental Microbiology, p. 183-270. In Sparks, D. L. (ed.), Advances in Agronomy, vol. 82. Elsevier Inc., San Diego, CA. 3. Zhou, J.-Z., and D. K. Thompson. 2002. Microarrays: Applications in Environmental Microbiology, p. 19681979. In Britton, G. (ed.), Encyclopedia of Environmental Microbiology, vol. 4. John Wiley & Sons, NY. Peer-Reviewed Journal Articles 1. Ravindranath, S., K. Henne, D. Thompson, and J. Irudayaraj. 2011. Raman Chemical Imaging of Chromate Reduction Sites in a Single Bacterium Using Intracellularly Grown Gold Nanoislands. ACS Nano, 5(6):47294736. 2. Henne, K. L., X.-F. Wan, W. Wei, and D. K. Thompson. 2011. SO2426 is a positive regulator of siderophore expression in Shewanella oneidensis MR-1. BMC Microbiology 11:125. 3. Ravindranath, S. P., K. L. Henne, D. K. Thompson, and J. Irudayaraj. 2011. Surface-enhanced Raman imaging of intracellular bioreduction of chromate in Shewanella oneidensis. PloS One 6(2): e16634. 4. Thompson, D. K., K. Chourey, G. S. Wickham, S. B. Thieman, N. C. VerBerkmoes, B. Zhang, A. T. McCarthy, M. A. Rudisil, M. Shah, and R. L. Hettich. 2010. Proteomics reveals a core molecular response of Pseudomonas putida F1 to acute chromate challenge. BMC Genomics 11:311. 5. Henne, K. L., C. H. Nakatsu, D. K. Thompson, and A. E. Konopka. 2009. High-level chromate resistance in Arthrobacter sp. strain FB24 requires previously uncharacterized accessory genes. BMC Microbiology 9:199. 6. Mugerfeld, I., B. A. Law, G. S. Wickham, and D. K. Thompson. 2009. A putative azoreductase gene is involved in the Shewanella oneidensis response to heavy metal stress. Applied Microbiology and Biotechnology 82:1131-1141. 7. Henne, K. L., J. E. Turse, C. D. Nicora, M. S. Lipton, S. L. Tollaksen, C. Lindberg, G. Babnigg, C. S. Giometti, C. H. Nakatsu, D. K. Thompson, and A. E. Konopka. 2009. Global proteomic analysis of the chromate response in Arthrobacter sp. strain FB24. Journal of Proteome Research 8:1704-1716. 8. Chourey, K., M. R. Thompson, M. Shah, B. Zhang, N. C. VerBerkmoes, D. K. Thompson*, and R. L. Hettich*. 2009. Comparative temporal proteomics of a response regulator (SO2426)-deficient strain and wildtype Shewanella oneidensis MR-1 during chromate transformation. Journal of Proteome Research 8:59-71. *Co-corresponding authors 9. Chourey, K., W. Wei, X.-F. Wan, and D. K. Thompson. 2008. Transcriptome analysis reveals response regulator SO2426-mediated gene expression in Shewanella oneidensis MR-1 under chromate challenge. BMC Genomics 9:395. 10. Wu, L., X. Liu, M. W. Fields, D. K. Thompson, C. E. Bagwell, J. M. Tiedje, T. C. Hazen, and J. Zhou. 2008. Microarray-based whole-genome hybridization as a tool for determining prokaryotic species relatedness. The ISME Journal (Multidisciplinary Journal of Microbial Ecology) 2:642-655. D. K. Thompson, Ph.D. Page 5 11. Thompson, M. R., D. K. Thompson, and R. L. Hettich. 2008. Systematic assessment of the benefits and caveats in mining microbial post-translational modifications from shotgun proteomic data: response of Shewanella oneidensis to chromate exposure. Journal of Proteome Research 7:648-658. 12. Luo, F., Y. Yang, J. Zhong, H. Gao, L. Khan, D. K. Thompson, and J. Zhou. 2007. Constructing gene coexpression networks and predicting functions of unknown genes by random matrix theory. BMC Bioinformatics 8:299. 13. Thompson, M. R., N. C. VerBerkmoes, K. Chourey, M. Shah, D. K. Thompson, and R. L. Hettich. 2007. Dosage-dependent proteome response of Shewanella oneidensis MR-1 to acute chromate challenge. Journal of Proteome Research 6:1745-1757. 14. Chourey, K., M. Thompson, J. Morrell-Falvey, N. C. VerBerkmoes, S. D. Brown, M. Shah, J. Zhou, M. Doktycz, R. L. Hettich, and D. K. Thompson. 2006. Global molecular and morphological effects of 24-h chromium(VI) exposure on Shewanella oneidensis MR-1. Applied and Environmental Microbiology 72:63316344. 15. Gao, H., Z. K. Yang, L. Wu, D. K. Thompson, and J. Zhou. 2006. Global transcriptome analysis of the cold shock response of Shewanella oneidensis MR-1 and mutational analysis of its classical cold-shock proteins. Journal of Bacteriology 188:4560-4569. 16. Brown, S. D., M. R. Thompson, N. C. VerBerkmoes, K. Chourey, M. Shah, J. Zhou, R. L. Hettich, and D. K. Thompson. 2006. Molecular dynamics of the Shewanella oneidensis response to chromate stress. Molecular & Cellular Proteomics 5:1054-1071. 17. Leaphart, A. B., D. K. Thompson, K. Huang, E. Alm, X. Wan, A. Arkin, S. D. Brown, L. Wu, T. Yan, X. Liu, G. S. Wickham, and J. Zhou. 2006. Transcriptome profiling of Shewanella oneidensis gene expression following exposure to acidic and alkaline pH. Journal of Bacteriology 188:1633-1642. 18. Brown, S. D., M. Martin, S. Deshpande, S. Seal, K. Huang, E. Alm, Y. Yang, L. Wu, T. Yan, X. Liu, A. Arkin, K. Chourey, J. Zhou, and D. K. Thompson. 2006. Cellular response of Shewanella oneidensis to strontium stress. Applied and Environmental Microbiology 72:890-900. 19. Liu, Y., W. Gao, Y. Wang, L. Wu, X. Liu, T. Yan, E. Alm, A. Arkin, D. K. Thompson, M. W. Fields, and J. Zhou. 2005. Genomic expression responses of Shewanella oneidensis MR-1 to salt stress. Journal of Bacteriology 187:2501-2507. 20. Wan, X.-F., N. VerBerkmoes, D. Stanek, L. A. McCue, D. Stanek, H. Connelly, L. J. Hauser, L. Wu, X. Liu, T. Yan, A. Leaphart, R. L. Hettich, J. Zhou, and D. K. Thompson. 2004. Transcriptomic and proteomic characterization of the Fur modulon in the metal-reducing bacterium Shewanella oneidensis. Journal of Bacteriology 186:8385-8400. 21. Gao, H., S. Wang, X. Liu, T. Yan, L. Wu, E. Alm, A. Arkin, D. K. Thompson, and J. Zhou. 2004. Global transcriptome analysis of the heat shock response of Shewanella oneidensis. Journal of Bacteriology 186:77967803. 22. Wu, L., D. K. Thompson, X. Liu, M. W. Fields, C. E. Bagwell, J. M. Tiedje, and J. Zhou. 2004. Development and evaluation of microarray-based whole-genome hybridization for detection of microorganisms within the context of environmental applications. Environmental Science and Technology 38:6775-6782. 23. Yost, C., L. Hauser, F. Larimer, D. Thompson, A. Beliaev, J. Zhou, Y. Xu, and D. Xu. 2003. A computational study of Shewanella oneidensis MR-1: Structural prediction and functional inference of hypothetical proteins. OMICS: A Journal of Integrative Biology 7:177-192. 24. Liu, Y., J. Zhou, M. Omelchenko, A. Beliaev, A. Venkateswaran, J. Stair, L. Wu, D. K. Thompson, D. Xu, I. B. Rogozin, E. K. Gaidamakova, M. Zhai, K. S. Makarova, E. V. Koonin, and M. J. Daly. 2003. Transcriptome dynamics of Deinococcus radiodurans recovering from ionizing radiation. Proceedings of the National Academy of Sciences 100:4191-4196. 25. Beliaev, A. S., D. K. Thompson, M. Fields, L. Wu, D. P. Lies, K. H. Nealson, and J. Zhou. 2002. Microarray transcription profiling of a Shewanella oneidensis etrA mutant. Journal of Bacteriology 184:4612-4616. 26. Thompson, D. K., A. S. Beliaev, C. S. Giometti, S. L. Tollaksen, T. Khare, D. P. Lies, K. H. Nealson, H. Lim, J. Yates III, C. C. Brandt, J. M. Tiedje, and J.-Z. Zhou. 2002. Transcriptional and proteomic analysis of a ferric uptake regulator (Fur) mutant of Shewanella oneidensis: Possible involvement of Fur in Energy Metabolism, Transcriptional Regulation and Oxidative Stress. Applied and Environmental Microbiology 68:881-892. D. K. Thompson, Ph.D. Page 6 27. Zhou, J., and D. K. Thompson. 2002. Challenges in applying microarrays to environmental studies. Current Opinion in Biotechnology 13:204-207. 28. Beliaev, A. S., D. K. Thompson, T. Khare, H. Lim, C. C. Brandt, G. Li, A. E. Murray, J. F. Heidelberg, C. S. Giometti, J. Yates III, K. H. Nealson, J. M. Tiedje, and J. Zhou. 2002. Gene and protein expression profiles of Shewanella oneidensis during anaerobic growth with different electron acceptors. OMICS: A Journal of Integrative Biology 6:39-60. 29. Wu, L., D. K. Thompson, G. Li, R. A. Hurt, J. M. Tiedje, and J. Zhou. 2001. Development and evaluation of functional gene arrays for detection of selected genes in the environment. Applied and Environmental Microbiology 67:5780-5790. 30. Thompson, D. K., C. D. Deal, C. Ison, J. Zenilman, and M. C. Bash. 2000. A typing system for Neisseria gonorrhoeae based on biotinylated oligonucleotide probes to PIB gene variable regions. Journal of Infectious Diseases 181:1652-1660. 31. Thompson, D. K., J. R. Palmer, and C. J. Daniels. 1999. Expression and heat-responsive regulation of a TFIIB homologue from the archaeon Haloferax volcanii. Molecular Microbiology 33:1081-1092. 32. Thompson, D. K., and C. J. Daniels. 1998. Heat shock inducibility of an archaeal TATA-like promoter is controlled by adjacent sequence elements. Molecular Microbiology 27:541-551. 33. Kuo, Y.-P.,* D. K. Thompson,* A. St. Jean, R. L. Charlebois, and C. J. Daniels. 1997. Characterization of two heat shock genes from Haloferax volcanii: A model system for transcription regulation in the Archaea. Journal of Bacteriology 179:6318-6324. (*Authors contributed equally to this work.) 34. Thompson, D. K. 1993. Arguing for experimental facts in science: A study of research article results sections in biochemistry. Written Communication 10:106-128. 35. Contributor for 1993 Bibliography: Relations of Literature and Science, 1989-1990. In Configurations 2:283319. 36. Thompson, D. K., and J.-S. Chen. 1990. Purification and properties of an acetoacetyl coenzyme A-reacting phosphotransbutyrylase from Clostridium beijerinckii (“Clostridium butylicum”) NRRL B593. Applied and Environmental Microbiology 56:607-613. Highlighted Conference Abstracts (> 50 total) 1. Wei, W., K. Chourey, X.-F. Wan, and D. K. Thompson. 2007. An orphan response regulator is involved in metal stress response pathways in Shewanella oneidensis MR-1. Poster presentation at the 107th General Meeting of the American Society for Microbiology, May 21-25, Toronto, Canada. 2. Thompson, D. K., K. Chourey, M. R. Thompson, S. D. Brown, N. C. VerBerkmoes, and R. L. Hettich. 2006. Functional genomics of the Shewanella oneidensis response to chromium stress and involvement of a DNAbinding response regulator. Poster presentation at the 11th International Symposium on Microbial Ecology (ISME), August 20-25, Vienna, Austria. 3. Thompson, D. K., K. Chourey, M. R. Thompson, S. D. Brown, N. C. VerBerkmoes, and R. L. Hettich. 2006. Functional genomics of the Shewanella oneidensis response to chromium stress. Poster presentation at the Gordon Conference on Microbial Stress Response, July 9-14, South Hadley, MA. LEGAL SCHOLARSHIP 1. Thompson, Dorothea K., Comment, Small Size, Big Dilemma: The Challenge of Regulating Nanotechnology, 79(3) TENN. L. REV. 621 (2012). 2. Thompson, Dorothea K., Note, Bankruptcy Law–Dischargeability of Student Loan Debt–Application of Federal Rule of Civil Procedure 60(B)(4) to Discharge-by-Declaration Provisions. United Student Aid Funds, Inc. v. Espinosa, 130 S. Ct. 1367 (2010), 78(1) TENN. L. REV. 287 (2010). D. K. Thompson, Ph.D. Page 7 3. Thompson, Dorothea K., Case Commentary, Grandfather clause codified in section 13-7-208(b)(1) of the Tennessee Code is not applicable to an establishment that, although classified as a prior legal commercial use, is not in operation before a change in state, county or municipal zoning regulations. Smith County Reg’l Planning Comm’n v. Hiwassee Vill. Mobile Home Park, LLC, 304 S.W.3d 302 (Tenn. 2010), 12(1) TRANSACTIONS: TENN. J. BUS. L. 259 (2010). 4. Thompson, Dorothea K., Comment, Postconviction access to a state’s forensic DNA evidence for probative testing: Not a freestanding constitutional right. District Attorney’s Office v. Osborne, 129 S.Ct. 2308 (2009). 6(2) TENN. J. L. & POL’Y 307 (2010). EDUCATION UNIVERSITY OF TENNESSEE COLLEGE OF LAW (KNOXVILLE, TN) Juris Doctor, May 2012 Activities: Executive Editor, Tennessee Law Review, 2011-2012; Staff Member, 2010-2011. Honors: James R. & Nell W. Cunningham First-Year Best Brief Award, 2011; Jerry J. Phillips Comment Award, 2012; Judge Harry W. Laughlin, Jr., Case Note Award; Excellence Awards in Patent Prosecution, Contract Drafting, and Administrative Law. THE OHIO STATE UNIVERSITY, DEPARTMENT OF MICROBIOLOGY (COLUMBUS, OH) Ph.D., Molecular Microbiology, Dec. 1997 (GPA 3.89/4.00) Thesis: Regulation of Gene Transcription in the Archaeon Haloferax volcanii Using the Heat Shock Response as a Model System (Major Advisor: Charles J. Daniels). Honors: J. Robie Vestal Award, Ohio Branch of the American Society for Microbiology, 1997; Marquis Who’s Who of American Women, 1997. PENNSYLVANIA STATE UNIVERSITY, DEPARTMENT OF ENGLISH (UNIVERSITY PARK, PA) M.A., English, with a specialization in Technical Writing/Scientific Discourse, May 1992 Thesis: Arguing for Experimental Facts in Science: A Study of Research Article Results Sections in Biochemistry. VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY, DEPARTMENT OF ANAEROBIC MICROBIOLOGY (BLACKSBURG, VA) M.S., Anaerobic Microbiology, Aug. 1989 Thesis: Acetoacetyl Coenzyme A-Reacting Enzymes in Solvent-Producing Clostridium beijerinckii B593. Honors: Omicron Delta Kappa Honorary Leadership Society, 1988. UNIVERSITY OF TENNESSEE (KNOXVILLE, TN) B.A., Microbiology and English, summa cum laude, June 1986 Honors: Phi Beta Kappa, 1985; Phi Kappa Phi, 1984; Woman of Achievement Award for Outstanding Accomplishment in Scholarship, 1983; academic scholarship awards, 1983-85. EDITORIAL ACTIVITIES, REFEREE WORK, AND PROFESSIONAL AFFILIATIONS Deputy Section Editor (10/2010-01/2014) for “Microbial Genetics, Genomics and Proteomics” Section and Associate Editor (08/2009-09/2010) on the Editorial Board for the open-access journal BMC Microbiology. Ad hoc reviewer for the following scientific journals: Journal of Bacteriology, Applied and Environmental Microbiology, FEMS Microbiology Letters, FEMS Microbiology Reviews, Applied Microbiology and Biotechnology, Journal of Clinical Microbiology, Archives of Microbiology, Genomics, Microbiology, BBA D. K. Thompson, Ph.D. Page 8 Proteins and Proteomics, Canadian Journal of Microbiology, BMC Genomics, BMC Microbiology, Journal of Applied Microbiology. Reviewed two chapters in the undergraduate textbook Microbiology: An Evolving Science (W.W. Norton & Company, Inc.). Ad hoc reviewer for the U.S. Department of Energy SBIR/STTR Program (2007, 2009), the DOE NABIR/ Environmental Remediation Sciences Program (ERSP) (2004, 2007), Austrian Science Fund (2006), Purdue Oncological Sciences Center Seed Grant Project (2006), and Veni Grant Program of the Innovational Research Incentives Scheme, The Netherlands Organization for Scientific Research (2009). Member, American Society for Microbiology. Affiliate Member, American Association of Colleges of Pharmacy INVITED PRESENTATIONS Insights into Metal Stress Response and Metal Reduction: Integrating Systems Approaches, Computational Analyses, and Nanotechnologies. Biosciences Division, Argonne National Laboratory, Argonne, IL, June 10, 2013. Optimization and Directed, Natural Evolution of Biologically Mediated Chromate Reduction in Subsurface Soil Microcosms. Plenary Session Presentation, 4th Annual DOE-ERSP PI Meeting, National Conference Center, Lansdowne, VA, April 22, 2009. Molecular Microbial Ecology of Chromate-Contaminated Soils. University of Tennessee, Knoxville, TN, April 2, 2009. Center for Environmental Biotechnology, Involvement of an Orphan Response Regulator in Metal Stress Response Pathways in Shewanella oneidensis. Department of Microbiology, The Ohio State University, Columbus, OH, April 26, 2007. Functional Genomics of the Shewanella oneidensis MR-1 Response to Metal Stress. Department of Microbiology and Biotechnology Institute, University of Minnesota, Minneapolis, MN, March 8, 2007. Functional Genomics of the Shewanella oneidensis MR-1 Response to Chromium Stress. Microbiology, Miami University of Ohio, Oxford, OH, April 12, 2006. Department of Functional Genomics of the Metal-Reducing Bacterium Shewanella oneidensis MR-1: Insights into Transcription Regulation and Stress Response Pathways. Department of Environmental Toxicology, University of California, Santa Cruz, CA, February 2004. Functional Genomics of the Metal-Reducing Bacterium Shewanella oneidensis MR-1: Insights into Transcription Regulation and Stress Response Pathways. Department of Biological Sciences, Purdue University, West Lafayette, IN, January 20, 2004. Functional Genomics of the Metal-Reducing Bacterium Shewanella oneidensis MR-1: Insights into Transcription Regulation and Stress Response Pathways. 11th International Conference on Microbial Genomes, Durham, NC, September 28-October 2, 2003. Transcriptome Dynamics of Deinococcus radiodurans Recovering from Ionizing Radiation. NASA Astrobiology Institute General Meeting, Phoenix, AZ, February 10-12, 2003. D. K. Thompson, Ph.D. Page 9 Using Microarray Technology to Analyze Microbial Community Structure and Function in Natural Environments. The 9th International Conference on Microbial Genomes, Gatlinburg, TN, October 28-November 1, 2001. Oligonucleotide Probes to PI Variable Regions. Gonococcal Typing Workshop at the 13th Meeting of the International Society for Sexually Transmitted Diseases Research, Denver, CO, July 15, 1999. The Development of an Oligonucleotide-Based Genotyping System for Neisseria gonorrhoeae. STD Interest Group, Johns Hopkins University, Baltimore, MD, May 19, 1999.
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