Cooling Mechanisms in 3D ICs: Thermo-Mechanical Perspective Satish G. Kandlikar1, Dhireesha Kudithipudi2 and Carlos A. Rubio-Jimenez1 1 Department of Mechanical Engineering 2 Department of Computer Engineering Rochester Institute of Technology, Rochester, NY, USA-14623 Abstract—Three-dimensional (3D) integrated circuits (IC) impose several challenges in thermal management. Stacking vertical layers significantly increases the heat dissipation per unit volume and the thermal footprint per unit area. The internal layers in the stacks are susceptible to high thermal gradients due to the low thermal conductivity interfaces and the distance from the heat sink. Several factors affect the thermal behavior of the 3D IC, including the through silicon vias, bonding, and cooling mechanisms. In this paper, we provide a detailed review of existing cooling mechanisms and their applicability to 3D ICs. We also propose two parameters to account for the thermal interactions among the devices and stack layers for incorporation in the 3D IC cooling system design: Thermal Intensification Factor (TIF) accounts for the increased heat flux due to multiple ICs along the heat transfer path, and Thermal Derating Factor (TDF) accounts for the increased thermal resistance introduced by the multiple layers. Also, a new flow passage design with variable fin density is presented to reduce the surface temperature non-uniformity along the coolant flow length. Keywords-Thermal Microchannels, 3D ICs. I. Management, Cooling, of through silicon vias (TSV), and the thickness of silicon contribute to the thermal budget. In addition, 3D ICs have higher thermal resistance along heat conduction paths to the heat sink causing larger temperature rise. The higher the number of strata greater is the effort in dissipating the heat, causing non-uniform performance, power, and reliability profiles. The temperature affects the reliability of 3D ICs in the following ways (i) diffusion effects (ii) dielectric breakdown (iii) ion movement (iv) electromigration (v) thermal cycling and (vi) performance drift. TSV, INTRODUCTION Three-dimensional (3D) integrated circuits (IC) are garnering significant attention in the recent past due to their several potential benefits. To realize a functional 3D circuit a number of innovative process technologies including wafer thinning, etching and filling of high aspect ratio holes in silicon, and wafer bonding are needed [1]. The main advantages of 3D ICs are reduced global interconnect lengths, increased circuit functionality, heterogeneous integration, smaller chip-footprint, greater power efficiency and new 3D circuit architectures [2-5]. Despite these advantages over planar 2D ICs, there are several challenges associated with 3D ICs. The two most significant challenges are (i) quality of the wafer-wafer bonding and (ii) thermal management in these architectures. Technology scaling and high integration density make the thermal management of 3D ICs particularly interesting and a multi-layer design problem. Increasing number of power sources and the close proximity of the heat sources from vertically stacked cores in 3D ICs exacerbates the thermal management problem in these systems; which can be detrimental to the performance as well as the reliability. The problem can be alleviated to an extent by choosing between face-to-face integration [1] or back-to-face integration [6] of the cores; analogous to placing a cold core on top of a hot core or vice versa. The number of strata in the 3D stack, the density and resistance 978-1-4577-1221-0/11/$26.00 ©2011 IEEE Figure 1. Representation of 3D IC with heat sink on the top. A high-level representation of a generic 3D IC is shown in Figure 1. In 3D ICs, integration can be achieved via vertically stacking heterogenous/homogenous cores in a single chip or multiple chip modules can be monolithically stacked in 3D. Each stack can have logic, memory, or hybrid devices integrated depending on the system requirements. TSVs enable communication between the different layers and play a pivotal role in the thermal management of the 3D ICs. The cooling layers between the stacks minimize the heat dissipated from the neighboring layers by coolants and thermal vias. There is a good body of evolving research on the thermal modeling and analysis in 3D ICs. Existing literature focuses on full chip thermal modeling and numerical analysis [1,713], optimal placement of TSVs for heat minimization [514], task scheduling for balanced heat distribution [3], CAD tool designs, etc. However, there has not been much focus on the cooling mechanisms and their impact on the 3D ICs, from a thermo-mechanical perspective. This paper provides a detailed analysis on the different cooling mechanisms and their feasibility for 3D ICs. We also present the idea of nonuniform temperature distribution across a core due to coolant fluids in the stacks. To minimize these heat variations and non-uniformity, a micro pin fin heat sink design is proposed. In addition, new metrics to measure the thermal characteristics of these systems are introduced. II. PARAMETERS AFFECTING THERMAL ISSUES IN 3D ICS The 3D IC encounters some unique thermal challenges that impact the system performance and reliability. In particular the following parameters and their impact on temperature are discussed in detail in the following subsections: (a) interface circuitry (TSV) (b) non-uniform heat distribution and (c) coolant fluid. A. Through-Silicon Vias TSVs are the vertical channels for heat, power and data delivery. TSV fabrication includes thinning of the wafer substrate to a thickness of sub-60 m. The TSVs have a pitch size ~5-25 m and requires microbumps in the vertical stacks. Typical TSV lengths vary between 10 to 100 m. TSVs are embedded in a silicon substrate. Depending on the application, the substrate can be either heavily-doped or lightly-doped. For example, in digital applications to guarantee that the entire substrate is equal-potential and alleviate latch-ups, heavy doping can be performed. There is a silicon-dioxide insulator layer between the metal fill and the silicon substrate. Copper filling helps with the thermal but has low throughputs and takes long time. All the TSVs are embedded in low-k dielectrics [15]. TSVs are most susceptible to mechanical failure as they experience mechanical stresses during the fabrication process. The repeated thermal cycling also introduces fatigue failure mechanism in these fragile microstructures. Therefore the placement of TSVs is crucial for minimizing the power and thermal budget of a 3D IC. The coolant channels sometimes compete with the TSV space and impose constraints on their locations. For example, if TSVs are located on the land regions only of a microchannel configuration, then a substantial region covered by the channels is not available for TSVs. The channels are designed to carry a large amount of heat with little pressure drop. This requires larger, meaning deeper, channels for a given overall size of the chip. Making channels deeper also causes the TSV lengths to increase and the interconnect delay is adversely affected. Cooling systems without these constraints are preferable, otherwise a designer needs to make judicious optimization of the overall size and placement of TSVs and coolant channels. Few researchers have used thermal vias to reduce the thermal problems, by electrically isolating the vias and reducing the effectivethermal resistances [16-17]. B. Non-Uniformity in Temperature The heat flow in the vertical direction in 3D ICs causes some temperature non-uniformity, especially if the cooling layers are not alternately stacked with the IC layers. In addition, when the local temperature non-uniformity due to hot spots is superimposed on this underlying temperature variation, it will result in significant temperature non- 978-1-4577-1221-0/11/$26.00 ©2011 IEEE uniformity along the fluid flow direction. The cooling system design therefore needs to be modified to reduce these effects. In case of the two-phase cooling, this temperature nonuniformity is significantly reduced, as the coolant temperature will in fact decrease along the flow direction due to lowering of the saturation temperature. This variation in saturation temperature needs to be combined with the variation in the heat transfer coefficient along the flow length of the evaporating coolant before the temperature variation of the substrate can be accurately determined. Although the temperatures on the entire chip are below the allowable limit, the in-plane thermal non-uniformity will affect the stresses induced at the TSV junctions. The differential expansion of the underlying substrate between adjacent TSVs, and the resulting stresses need to be carefully evaluated for establishing the allowable limits for temperature gradients. There is another cause of temperature non-uniformity caused by the temperature differences between two adjacent channels. If a fluid flowing in a channel receives more heat than its adjacent channels, then there will be a temperature difference between the channel surfaces near the outlet, resulting in large temperature gradients in the lateral direction to the channels. These non-uniformities will result in performance variations in different circuits across the chip. If the critical path circuits are affected by such temperature variations then it might lead to generating garbage output values. For example, consider a stack in the 3D IC that has hybrid devices integrated: logic and memory. If the non-uniformity will increase the temperatures on the memory units then the data write and read performances might be destructive on the extreme. Realistically, a thermal management unit will be activated to address such unexpected spikes. However, if the ranges are below the thresholds then the thermal management unit might not be activated. Therefore, it is important to address these challenges during the design phase. III. COOLING MECHANISMS A. Cooling Options for 2D IC Chips The three possible coolants to use in 3D ICs are air, single-phase liquid, or a boiling liquid. Air is preferable because of the simplicity in the overall system design and operation. However, the power dissipation levels of air are quite low. This may not be an issue in cases where the system speed is of great importance, but the overall power dissipation is low e.g. mobile devices and notepads. Single-phase cooling with liquid is perhaps the best solution available for use with microchannel coolers. It is preferable to use water from a heat transfer perspective because of its superior heat transfer characteristics. However, water may become a concern if there are any chances of leakage from the system such that water may come in direct contact with chips. To avoid this danger, dielectric fluids such as refrigerants are often employed. Since the thermal conductivity and other heat transfer characteristics of the dielectric fluids are considerably lower than water, the heat removal capability with these liquids is significantly reduced. Boiling a liquid as it picks up heat from the devices is a very efficient technique because of the large latent heat associated with the phase change process. The mass flow rates are considerably reduced. Another advantage of a twophase system is the uniformity of the coolant temperature. When employed in channels, the saturation temperature of the fluid decreases in the flow direction due to the pressure drop along the flow length. Water again has the most desirable thermal characteristics because of its large latent heat. However, the saturation temperature of water at 1 atmospheric pressure is 100°C, which is higher than the upper limit of junction temperatures for the chips. Water may be used under sub-atmospheric pressures to provide a lower operating temperature. The issues related to leakage into the system, and large specific volume of the vapor need to be properly addressed. Low pressure water remains among one of the possible alternatives. Using refrigerants with more operating pressures slightly above atmospheric is another viable alternative. The dielectric properties of the refrigerant are desirable in bringing the coolant closer to an IC. The latent heat of evaporation for refrigerants is generally almost an order of magnitude lower than that for water. Thermal performance for the refrigerant systems is therefore not as attractive as with water. However, it is a good alternative for cooling ICs. For high heat flux removal, single-phase and two-phase systems with water and refrigerants are receiving attention. Water based coolants are attractive because of their favorable thermal properties such as high thermal conductivity, high specific heat, and in the case of flow boiling systems, a high latent heat. Water also has a high dielectric constant of 78.5 and is thereby amenable as a coolant. B. Design Approach for 3D IC Stacks Cooling of a 3D IC stack uses the 2D IC cooling technologies as its basic building block. However, the 3D architecture introduces thermal interactions among the devices and additional thermal resistances that need to be considered. Two new parameters are introduced that take into account these effects. The objective of a good thermal design approach is to bring these interaction terms close to unity so that a cooling system is effective in a 3D configuration by reducing the hot spots and provide more uniform temperature distribution. Heat removal from the top layer in a conduction cooling system is similar to the cooling techniques employed for planar IC chip cooling. Because of the multiple devices appearing in the heat flow path, and because of additional thermal resistances, two factors are introduced. The Thermal Intensification Factor, TIF, takes into account the presence of multiple heat generating devices 978-1-4577-1221-0/11/$26.00 ©2011 IEEE present in the thermal path from the bottom layer to the top layer. Assuming each device is generating same heat flux, then TIF would be 0.5; however, heat spreading or presence of other evices in the vicinity might alter the TIF value. If the device placement is made judiciously to avoid series paths and device interactions, then TIF would approach 1. (1) where q”3D-U is the uniform heat flux based on the total power dissipated in a 3D IC stack divided by the active cooled area, and q”3D-H is the maximum heat flux in a hot spot of the 3D stack considering the device overlap and interaction effects. This factor in effect considers the localized cooling of the hot spots. For heat balance of the coolant loop, it is appropriate to use the uniform heat flux q”3D-U, while for calculating maximum device temperature for safe operation, use of the maximum heat flux in a hot spot q”3D-H is recommended. The Thermal Derating Factor, TDF, considers the additional thermal resistances introduced in a 3D stack. Since the coolant is placed over the top layer, an equivalent heat flux that would be representative of a single IC layer is used in the design calculations. (2) Alternatively, (3) TDF depends on the additional resistances introduced in a 3D IC due to (i) conduction resistance in the additional dies, after factoring in the conduction in TSVs and TVs, (ii) interface resistance between the layers, (iii) additive effect due to multiple heat sources in the heat conduction path, which depends on the device placement strategy employed. The equivalent 2D maximum heat flux corresponding to the maximum heat flux in a 3D stack is given by: (4) It is imperative that for the energy balance calculations for the coolant, q”1D-U is used and for the local hot spot temperature calculations with heat transfer coefficients and other thermal resistances, q”1D-H is used. Thus, to design a microchannel system on the top layer to meet the thermal requirements, the design should be based on q”1D-H. The value of TIF is greater than 1, and TDF is less than 1. This requires a cooling system for a 3D IC stack to be designed for a larger heat flux removal capability than a 1D planar chip. For a good 3D IC stack design, both TIF and DIF should be close to 1. C. Evaluation of Cooling Options For the high heat flux systems, three options that are attractive are single-phase jet impingement, microchannels with single-phase flow, and microchannels with two-phase flow. Kandlikar and Bapat [18] present a critical evaluation of these techniques for removing heat fluxes of the order of 1 kW/cm2. Jet impingement using liquid is an effective technique in which high speed jets issue from nozzles and impinge on the target kept at some distance away from the jet. A single jet provides efficient heat removal in the immediate vicinity of the central region of a jet. The liquid film becomes thicker farther away from the jet centerline, thereby introducing increased thermal resistance. Using multiple jets that are closely placed effectively overcomes this problem. The multiple jet configurations can be fabricated using microfabrication technology. Further improvements in the heat transfer performance of multiple jets can be achieved by introducing enhanced surfaces on the target plate. The main drawback of the jet impingement cooling technique is the high pressure requirement to drive the jets and the system design could become quite complex with multiple headers for supplying and removing liquid. The required pressures in some of the designs were between 70 and 500 kPa. For the 3D IC cooling, jet impingement is not well suited mainly because of the large space requirement for the jets and the manifolds behind them. This additional space requirement for jet impingement cooling will work against the benefits gained from the 3D architecture. Spray cooling is another option that has been investigated in literature for planar chip cooling application. In this system, fine droplets of liquid are sprayed on a substrate where the liquid spreads and evaporates rapidly. The heat transfer rates could be as high as 250 W/cm2 with water. The pressure and space requirements for these systems are even higher than the jet impingement systems. Spray cooling option is thus not suitable for 3D IC cooling as well. Microchannel cooling option was another option evaluated by [18]. It provides some unique benefits of high performance and possibility of integration within the multiple die layers. i) Conduction Cooling of 3D ICs Stacking multiple die layers makes heat removal a difficult task. For total heat fluxes in the range of 100-200 W/cm2, high heat flux removal IC cooling systems may be viable. Since heat generated in the inner dies is removed by conduction to the top layer, this technique is called as conduction cooling. It should not be confused with other systems where heat flows in the in-plane direction and then is removed by employing heat pipes or other techniques. Figure 2 shows some of the options available for removing heat from a 3 layer die set. The dies may be mounted face-to-face or face-to-back depending on the 978-1-4577-1221-0/11/$26.00 ©2011 IEEE overall heat load and placement of different heat producing devices in relation to the overall assembly. Aggressive air cooling desing with compact HX Face-to-back packaging Aggressive air cooling desing with compact HX Hybrid face-to-back and face-to-face packaging a) Coolant inlet and outlet Pool boiling with vapor space condensation Hybrid face-to-back and face-to-face packaging b) Top cover for microchannels Microchannels on the backside of a chip Hybrid face-to-back and face-to-face packaging c) Figure 2. Integrated conduction cooling of 3D ICs with other cooling systems: (a) aggressive air cooling with compact HX, (b) pool boiling with vapor space condensation, (c) microchannel cooling. The hybrid packaging shown in Figures 2(a) and (b) allows for the shortest TSV, but the thermal effects of devices facing each other may have to be considered. In the first design (a), the top die is treated like a high power chip and an aggressive air cooling with a compact heat exchanger is employed. The limit for air cooling is around 80-100 W/cm2. For low power applications, other less aggressive air cooling options may be pursued. The system shown in Figure 2(b) employs pool boiling heat transfer. The top die interfaces with the pool boiling liquid, either directly or through an intermediate container base. It may be desirable to incorporate some pool boiling enhancement technique, such as artificial cavities or open microchannels. Recent work by Cooke and Kandlikar [19] has yielded a heat removal rate of 300 W/cm2 and a heat transfer coefficient of 280,000 W/cm2°C with water. A chamber with vapor space condensation and an external coolant loop removes the heat away from the system. The third system shown in Figure 2(c) employs microchannels etched in the silicon on the back-side of the top layer. The arrangement is similar to a planar IC chip cooling. In this case, the aggressive design with multiple inlet and outlet headers and offset strip fins employed by Colgan et al. [20] may be employed. Although the heat transfer rates obtained in a single chip cooling of 790-1000 W/cm2 may be achieved, the maximum temperature encountered in the bottom layer of the stack is expected to limit the heat fluxes that can be dissipated as dictated by the TIF and TDF discussed earlier. As seen from the above examples, the heat generated in each layer flows to the top layer in conduction cooling. Heat is then dissipated using the established techniques. decade. Because of the small dimensions, the flow is laminar in chip cooling application. As the flow channel dimensions become smaller, the heat transfer coefficient improves in inverse proportion. However, the pressure drop also goes up, in an inverse cubic proportion as the diameter decreases. To overcome this problem, short flow lengths are employed. a) Single-pass arrangement b) Split-flow arrangement c) Offset strip fin geometry in microchannels Moreover, the wafer thinning in a multiple layer structure is implemented to reduce the TSV lengths. Wafer thinning is also advantageous from the cooling perspective as it reduces the thermal resistance of the silicon substrate. At high heat fluxes, this resistance is not insignificant and wafer thinning offers benefits from both electrical and thermal design viewpoints. For low to medium heat flux systems, conduction cooling is thus seen as an attractive option for a 3D IC stack. ii) Microchannel Cooling Following the definition presented by Kandlikar and Grande [21], channels with hydraulic diameters in the range 10-200 µm are classified as microchannels, and those in the range from 200 µm to 3 mm are termed as minichannels. Because of the small thickness of the wafer, microchannels are commonly employed on the back of a chip for direct cooling. An exhaustive history and a critical review of developments in this field are represented by Kandlikar [22]. Currently practical solutions utilizing single-phase liquid flow in microchannels are available for meeting planar IC cooling needs of up to 790-1000 W/cm2. A brief overview of the microchannel cooling technology with single-phase flow with liquid and flow boiling is presented below. iii) Single-Phase Microchannel Cooling Single-phase cooling options with water or water-based solutions have received considerable attention in the last 978-1-4577-1221-0/11/$26.00 ©2011 IEEE d) Offset strip fin geometry in microchannels Figure 3. Plain and enhanced microchannels and their performance [23]. Kandlikar and Upadhye [23] proposed a two-pass arrangement which reduced the flow length and flow rates by half. In addition, the plain microchannels were replaced by an offset strip fin geometry to provide higher heat transfer rates with low pressure drops. Figures 3(a)-(d) show the single-pass and the split-flow geometry, the offset strip fin geometry and the heat load versus pressure drop performance for these arrangements. The split-flow geometry with offset strip- fin geometry is able to dissipate 300 W with a pressure drop of 24 kPa. A heat transfer coefficient of around 500,000 W/m2°C was experimentally determined by Steinke and Kandlikar [24] for this geometry. Colgan et al. [20] employed offset strip fin geometry with multiple inlet and outlet headers to dissipate 790 W/cm2 from a chip. Their conceptual design is shown in Figure 4. Figure 5(b). An active cooling area of 10 mm x 10 mm is considered. a) Sketch of micro pin fins heat sink Figure 4. An advanced chip cooler design with offset strip fins and multiple headers [20]. iv) Flow Boiling in Microchannels for Cooling 3D ICs Flow boiling in microchannels has been extensively studied in the last decade. Concerns regarding the flow instability and the lower than expected heat transfer coefficients and critical heat fluxes have hindered its practical implementation. Some of the techniques such as addition of active nucleation sites and introduction of inlet restrictors have shown promise, e.g., Kandlikar et al. [25], Kosar et al. [26]. v) Temperature Uniformity Considerations The temperature uniformity is an important consideration in the design of 3D-IC stacks. Although high heat transfer coefficients can be achieved with a single-phase coolant, coolant and substrate temperatures rise along the flow length. Increasing the coolant flow rate reduces the coolant and consequently the chip surface temperature non-uniformity, but increases the coolant pressure drop. A new flow channel design with variable fin density is presented here to reduce the temperature non-uniformity without excessive pressure drop penalty. The conventional pin fins with uniform fin density is shown in Figure 5(a) and the new propose design with increasing fin density along the flow length is shown in 978-1-4577-1221-0/11/$26.00 ©2011 IEEE b) Sketch of micro pin fin network with variable fin density Figure 5. a) Conventional uniformly spaced pin fins and b) proposed new design with increasing fin density along the flow length 360 Fluid Novel micro pin fin heat sink Micro pin fins heat sink Microchannel heat sink 350 Temperature [K] The earlier systems investigated have focused on introducing subcooled liquid into microchannels. After reaching saturation condition in the microchannel, it would begin to boil. This configuration allows for a liquid pump. However, if a refrigeration loop is incorporated with a throttle valve at the inlet of the microchannels, there are no instabilities. Such arrangements are also attractive as the refrigerant temperature in the evaporator could be below the room temperature thereby increasing the heat fluxes that can be removed from of the unit. The condenser of the system would then be able to dissipate heat directly to the air. 340 330 320 310 300 290 0.0 0.5 x/L 1.0 Figure 6. Temperature variations of fluid and substrates of different heat sinks along the flow direction, q”=100 W/cm2, Tinlet=293 K, flow rate =1.5 mL/s The conventional heat sink is formed by 6534 rectangular pin fins (50 m width, 100 m length and 200 m height). The transversal (perpendicular to flow direction) and longitudinal (parallel to flow direction) pitches are 100 m and 150 m, respectively. The base has a 200 m thickness. The micro pin fin heat sink with variable density is formed by 4752 flat pin fins (50 m width, 100 m length and 200 m height) placed on 3 sections: 1. 330 pin fins are placed on 33 transversal and 10 longitudinal rows at this section (from the fluid inlet) with ST and SL of 300 m and 150 m, respectively. 2. 2244 pin fins are placed on 66 transversal and 34 longitudinal rows at the second section (middle of the heat sink) with ST and SL of 150 m. 3. 2178 pin fins are placed on 99 transversal and 22 longitudinal rows at the third section (near the fluid outlet) with ST and SL of 100 m and 150 m. 80.0 70.0 DP [kPa] 60.0 50.0 40.0 30.0 20.0 10.0 0.0 Microchannel heat sink Micro pin fins Novel micro pin heat sink fin heat sink Figure 7. Comparison of coolant pressure drop for the three heat sinks for mass flow rate =1.5 mL/s. A numerical analysis using FLUENT software is performed considered 1.5 mL/s of water in laminar regime and single phase. The fluid inlet temperature was set at 293 K. The heat flux applied was 100 W/cm2. The results of the (i) heat sink and coolant temperature variation, and (ii) pressure drop are presented in Figures 6 and 7 respectively. Conventional microchannel heat sink formed by 33 channels with 200 m height, 10 mm length, 100 m space between channels and = 1.0 is considered for comparison. Since the heat transfer coefficient and surface area are uniform throughout for the uniform density pin fins, a rise in coolant temperature leads to a corresponding increase in the heat sink temperature as shown in Figure 6. Similar trend is observed for a microchannel heat sink, although the heat sink temperature is higher due to relatively large microchannel sizes employed. Decreasing the microchannel size will result in lower heat sink temperatures, but the temperature rise will be same along the flow direction. In the new design, the increasing fluid temperature along the flow length is offset by the increased heat transfer rate due to increased fin density along the flow length. This results in a more uniform temperature variation. Comparing the values from Figure 7, the temperature variations are: 38°C for microchannels, 17°C for uniform pin fins, and only 8°C for the new design shown in Figure 5(b). It employs a step-wise variation in fin 978-1-4577-1221-0/11/$26.00 ©2011 IEEE density; a continuously increasing fin density variation may yield an even lower temperature variation. vi) Thermal Modeling of 3D IC Stack A number of researchers have modeled the thermal performance of a 3D IC stack cooled by microchannel interlayers. A number of advanced simulation models have been presented in the literature and they provide valuable guidance for future development in this field [16,27-31]. IV. CONCLUSIONS AND FUTURE RESEARCH NEEDS IN 3D IC THERMAL MANAGEMENT The 3D IC stacks present some new challenges in the thermal management. The cooling mechanism is considerably altered due to additional consideration of thermal interactions among devices, hot spots, modifications in the thermal paths and introduction of additional thermal resistances. Some of the research needs in this emerging area are listed herein. The placement of IC devices in different layers is perhaps the single most important factor in the successful thermal management of 3D IC stacks. Two new parameters, Thermal Intensification Factor (TIF) and Thermal Derating Factor (TDF) are introduced to account for the thermal interactions among devices and additional thermal resistances introduced due to 3D stacking. Design strategies and procedures need to be developed for device placements to yield a low value of the TIF to limit the hot spot temperatures and reduce the demands on the cooling system design. Thermal designs need to be developed to yield a low value of TDF, close to one, to increase the thermal dissipation rate. The microchannel cooler employed in interlayers need to be developed to meet the 3D IC stack requirements of allowable pressure and pressure drop. Enhancement techniques, and novel designs such as utilizing increasing pin fin density along the flow lengths need to be developed and optimized for the pressure drop, heat transfer, and temperature uniformity constraints New designs of manifolds are needed for ascertaining uniform flow distribution in each channel of a microchannel cooler chip. Packaging is a critical issue in assuring leak-proof, reliable thermal management cooling system. Novel Thermal insulating materials such as Graphene, which can be used as interconnects or heat spreaders for better thermal conductivity. Suitable coolants need to be developed. Water based coolants have better heat transfer performance. 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