Supplementary Table I. Correlations (R2) between metformin with creatinine, lactate and pH for each patient with MALA.
Patient
1
2
Metformin vs creatinine
0.928***
0.929***
3
ND
4
0.829
5
0.931**
6
0.976***
7
ND
8
0.894***
9
0.339
10
0.666**
11
0.891***
12
0.534**
13
0.032
14
ND
15
ND
Bruijstens et al. (2008)
1
0.857***
2
ND
3
ND
***
**
*
Level of significance:
P<0.001; P <0.01; P <0.05.
ND = not done, less than 5 paired samples.
R2
Metformin vs lactate
0.733
0.354
Metformin vs pH
0.897*
0.577*
ND
ND
ND
0.879*
ND
ND
ND
0.836**
0.659**
0.655
ND
0.031
ND
ND
ND
0.904*
0.924**
ND
0.981***
ND
0.910***
0.185
0.640*
ND
0.355
ND
0.583
ND
ND
0.961**
ND
ND
Supplementary Figure 1. Concentration time-profiles for the plasma concentrations of
metformin, creatinine and lactate and arterial pH in each patient. All patients received
continuous renal replacement therapy (CRRT) but the duration of CRRT was only
known in some patients (shaded areas).