Poster
48
Advances in the Discovery of potential Antimalarial Therapies derived from Phenotypic screening
 Artemisinin based combination therapies (ACTs) are in danger :
NEW DRUGS ARE NEEDED  Phenotypic Screening Tres Cantos Antimalarial Set (TCAMS)  What do we need for a good antimalarial?
‐ in vitro & in vivo potency
‐ No Tox issues
‐ Fast acting
‐ Low frequency of resistant mutant generation
‐ Novel mechanism of action
‐ Oral bioavailability
‐ Potential for single dose cure

... WE ARE CLOSE !!!
Having all these properties in one hit can be a challenge
but ...
Strategy & Advances presented in the poster 48

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