Aminoacylpyrrolidines as Leishmanial N‐Myristoyltranferase Inhibitors
23
Jennie A. Hickin, Victor Goncalves, James A. Brannigan, Thomas Waugh, Anthony J. Wilkinson,‐
Edward W. Tate, Deborah F. Smith, Robin J. Leatherbarrow.
Leishmaniasis causes 70,000
deaths a year
NMT
Target protein
+
CoA‐SH
NMT is an essential enzyme in Leishmania
Structure‐
guided design
HTS
150,000 Compounds
4 Compound Series
Highly potent Leishmania NMT inhibitors