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Development of a Single‐Molecule Force Based Approach for Fragment Screening
Gabrielle A. Milson, Peter M. Fischer, Philip M. Williams and Stephanie Allen
Streptavidin Receptor
Biotin Mimetic Peptide
Advantages of the
Atomic Force Microscope
• Sensitive • Low volumes of ligand and receptor required
• Works at single molecule level
• Label free •#
Percentage Adhesion /%
Potential Fragment