P10
Realising Lead‐Oriented Synthesis
The Organic Chemistry Universe is “Top Heavy”
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Lead‐oriented synthesis (LOS) seeks to address high attrition rate of drug candidates.
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Defined ‘lead‐like’ properties allow for focussed lead identification.
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Our poster describes:
1. A bespoke computational tool for identifying molecular scaffolds and synthetic methodologies of high value.
2. The development of a chemical tool‐kit used to exemplify a library of lead‐like scaffolds that are also of value as novel fragments.
Daniel J. Foley, Richard G. Doveston, Ian Churcher, Stephen P. Marsden and Adam Nelson