a
30
120
25
110
20
% of the initial wound size
100
15
90
10
80
5
70
0
*
*
*
13
17
60
50
PBS
40
AAV-LacZ
30
AAV-FGF4-IRES-GFP
20
AAV-VEGF165
10
AAV-FGF4-IRES-VEGF165
*
0
0
1
3
5
7
9
11
13
*
15
*
*
15
*
*
17
19
*
19
21
days after GT
b
PBS
AAV-LacZ
AAV-FGF4IRES-GFP
AAV-VEGF165
AAV-FGF4IRES-VEGF165