LIFE SCIENCE TECHNOLOGIES
Produced by the Science/AAAS Custom Publishing Office
NEW PRODUCTS: LIPIDOMICS
Glycan Quantitation Analysis
High Throughput Lipid Analysis
LIPOTYPE has designed a high throughput technology called Shotgun Lipidomics based on the Hamilton STARlet
platform in combination with a mass
spectrometer and LIPOTYPE’s proprietary software, LipotypeXplorer. The
platform allows comprehensive and
absolute quantitative lipidomic analysis
from different types of up to 96 clinical
or biological samples in three hours. The
system is designed in a way that allows
an easy adaption to various extraction
procedures. All kinds of organic solvents
for the lipid extraction can be handled in
a reliable way using Hamilton’s Anti Droplet Control technology. All liquid transfer
steps are checked for accuracy and reproducibility using a balance to determine
the real pipetted volume. The complete
method validation included extraction of
90 copies of the same sample arrayed
together on a single plate. Three independently prepared replicates of such plates
were independently processed and analyzed on three consecutive days to check
intraday and interday variation.
LIPOTYPE GmbH
For info: +49 351 796 53 45
www.lipotype.com
Metabolomics/Lipidomics
Analyses Software
qTOF Mass
Spectrometers
The maXis line
of ultrahigh
resolution
quadrupole timeof-flight (UHRqTOF) mass
spectrometers
brings industryleading
resolution and
mass accuracy
to the liquid
chromatography,
time-of-flight MS
market space.
The system
is designed
to deliver
outstanding
resolution
and mass
accuracy that, for example, allows for
unambiguous identification of the monoisotopic mass peak of both the light and
heavy chains of monoclonal antibodies.
In addition, this level of performance also
provides scientists confident detection
and identification of modifications hard
to detect at the protein level, such
as deamidation. The maXis II system
delivers the fastest time-to-success for
life science researchers and across a
broad range of applications from the indepth identification and characterization
of biopharmaceuticals and small
molecule pharmaceuticals to bottom-up
proteomics and proteoform screening.
Bruker
For info: 978-663-3660 www.bruker.com
Progenesis QI Version 2.0 is the next
generation of liquid chromatographymass spectrometry (LC-MS) software
for small molecule 'omics data analysis.
This software complements the earlier
introduction of Progenesis QI for
proteomics Version 2.0 for large molecule
'omics data analysis. Both Progenesis
QI and Progenesis QI for proteomics
software take LC-MS data analysis to
new levels of speed and sophistication,
enabling users to rapidly quantify and
identify the significantly changing small
molecule, lipid compounds, and proteins in samples. The new
features of Progenesis QI Version 2.0 include Pathway Mapping,
which facilitates the process of placing discoveries into a biological
context, extracting maximum value from 'omics data; workflow
automation, which enables the software to move through multiple
processing stages without user intervention; improved access to
compound databases; and seamless integration with the extended
statistics functionality in EZInfo 3.0, with two-way dataflow to allow
for flexible data mining through a single, menu-driven command.
Waters Corporation
For info: 800-252-4752
www.waters.com
Enterprise Edition of SimGlycan v. 5.0 is
a comprehensive high throughput tool
that provides support for glycan quantitation using Thermo Scientific aminoxyTMT for MS/MS glycan data analysis
workflows. Additionally, it can be used
for processing of liquid chromatography/
mass spectrometry (LC-MS) data for
peak detection, peak picking, and alignment of glycans based on retention time,
precursor m/z values, and observed
intensities across multiple samples. The
Thermo Scientific aminoxyTMT reagents
are designed to provide efficient relative
quantitation of carbohydrates, improve
labeled-glycan ionization efficiency, and
increase analytical throughput. These
reagents can be used for quantitative
analysis of native N-glycans by direct or
LC-coupled ESI-MS. Using SimGlycan,
glycans are quantified by measuring
reporter ion peak intensities from the
corresponding MS/MS spectra. Various
charts are provided to facilitate visualization of either the quantity of each glycan
in different TMT channels or relative
change in abundance of glycans across
samples.
Premier Biosoft
For info: 888-847-7494
www.premierbiosoft.com
Lipid Analysis Software
Complementing Protein Metrics’
advanced Byonic protein identification
engine, Lipify software makes structural
identifications across an expanding
list of lipids (>20,000), covering many
lipid subclasses, to provide automated
processing of high throughput liquid
chromatography-tandem mass
spectrometry (LC-MS/MS) data. Lipify
provides structural characterization as
part of the identification process. This
unique tool can even characterize lipids
that have never been observed before, opening the door to new
biological and medical discoveries. The Lipify software offers a
friendly graphical user interface to allow scientists to interact with
results and provide intuitive views of analyzed data that aids manual
verification of identifications. Its algorithms are sensitive and
efficient, with a typical search of 26,000 lipid targets completed in
less than 15 seconds. Results can be readily exported for reporting
and publication.
Protein Metrics
For info: 650-412-4210
www.proteinmetrics.com
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