LIFE SCIENCE TECHNOLOGIES
Produced by the Science/AAAS Custom Publishing Office
NEW PRODUCTS: PROTEOMICS
Validated Antibodies
A new product line of PrecisonAb Antibodies has been rigorously validated for
use in Western blotting. These antibodies offer superior sensitivity, specificity,
and reliability. They also come with the
industry’s most complete validation data
so researchers can accurately assess the
antibodies’ performance before buying,
and a positive control lysate so researchers can optimize the antibodies in their
own labs. These are the first of thousands
of PrecisionsAb Antibodies Bio-Rad plans
to release to help researchers improve
their Western blotting results. Scientists
have struggled with antibody unreliability for decades because manufacturing
standards and quality control vary widely
among vendors, targets, and even among
antibody lots. PrecisionAb Antibodies are
screened using whole-cell lysates from
up to 12 different biologically relevant cell
lines—by far the industry’s most rigorous
validation process. Only antibodies that
detect endogenous protein levels with
high sensitivity and specificity are included in the PrecisionAb product line.
Bio-Rad For info: 800-424-6723
www.bio-rad.com/precisionabpr
Protein Pegylation Service
Conjugated Antibodies
Protein Digestion Kit
A new tool for protein digestion, the
SMART Digest kit is designed to
substantially reduce preparation times
and associated errors, facilitating fast,
reliable analytical results. Current protein
digestion techniques comprise complex
procedures requiring determination
of protein concentration followed by
sample reduction and alkylation prior to
digestion with trypsin. To improve this
operation, the kit uses a simple three-step,
easy-to-implement process that can be
automated. Its immobilized trypsin design
is formulated for high-quality data with a
significantly reduced sample preparation
time compared to traditional in-solution
digestion methods. The increased
reproducibility of digestion possible with
this kit should enable users to implement
generic, rapid, and robust methods for
high-throughput sample processing.
The SMART Digest kit is also designed
to provide higher sequence coverage
while reducing both chemically induced
posttranslational modifications and the
number of chemicals in the final sample.
Thermo Fisher Scientific
For info: +45-70-23-62-60
www.thermoscientific.com/smartdigest
Pegylation services are now offered to
customers developing protein-based
therapeutics and biosimilars through a
new collaboration with Celares GmbH.
The service offering includes feasibility
studies, process and analytical development, and scale-up from milligram
to gram quantities required for pilot
and subsequent commercial scale. Pegylation, the attachment of polyethylene
glycol (PEG) to a molecule, can significantly improve the pharmacological and
physicochemical properties of peptide
and protein therapeutics and reduce side
effects. This well-recognized delivery
system for biologics can enhance protein
stability, bioavailability, and solubility,
overcoming common challenges in the
development of these therapeutics. The new services will leverage
EMD Millipore’s broad range of functionalized PEG products of different molecular weight and activation chemistry, as well as buffers,
solvents and excipients, and unit operations employed during the
pegylation process and subsequent purification, including tangential and normal flow filtration and chromatography.
EMD Millipore
For info: 800-645-5476
www.emdmillipore.com
A new range of conjugated antibodies
leverages Innova’s Lightning-Link and
InnovaCoat bioconjugation technologies
to provide customers with antibodies
conjugated to an extensive range of
enzymes, fluorescent dyes, and colloidal
gold for improved flexibility in experimental design. The new range comprises
200 antibodies to nearly 30 different cardiac biomarkers, each available directly
conjugated to 24 different enzymes, fluorescent dyes, or nanoparticles. In conjunction with the new range, a new corporate website provides customers with
easier online ordering facilities, as well as
access to a range of resources and support materials. The website also features
an Antibody Conjugate Generator tool,
which enables customers ordering from
the new conjugated antibodies range
to select any desired cardiac marker,
antibody clone, and label. The online
Conjugate Generator provides customers with unprecedented flexibility, speed,
and conjugation possibilities, enabling
highly tailored reagents to be created at
a fraction of the cost of a custom conjugation project.
Innova Biosciences
For info: +44-(0)-1223-496170
www.innovabiosciences.com/products/
antibody-conjugates
Host Cell Protein Detection Kit
The Gyrolab CHO-HCP Kit 1 detects
and quantifies host cell proteins (HCPs)
from Chinese hamster ovary (CHO)
cells used in the bioprocessing of
biotherapeutics. HCPs are measured
throughout the production process, as
they may affect the safety and efficacy
of the biotherapeutic. The kit has been
validated for use on the Gyrolab xP
workstation and the new Gyrolab xPlore
and is ready to use, eliminating the need
for time-consuming assay development.
The automation capabilities of Gyrolab
systems enable 96 data points to be
generated in approximately 1 hour without manual intervention,
saving time and reducing errors and repeats. The kit broadens the
analytical range from typically two orders of magnitude to four, and
therefore requires fewer dilutions and fewer reruns than alternative
methods. The kit contains all the reagents needed to produce 96
data points, including a specific Bioaffy CD that has been optimized
for this HCP assay.
Gyros
For info: +46-(0)-18-566-300
www.gyros.com
Electronically submit your new product description or product literature information! Go to www.sciencemag.org/products/newproducts.dtl for more information.
Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations
are featured in this space. Emphasis is given to purpose, chief characteristics, and availability of products and materials. Endorsement by Science or AAAS of any
products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.
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