amendments (PDF: 189KB/9 pages)

Minnesota Department of Health Division of Environmental Health
Web Publication Date: August 16, 2010 Note: The HRL values noted below are derived using the methods specified in Minnesota Rules, parts 4717.7830, 4717.7840, and 4717.7850. For each chemical, the following is provided: the chemical name; the CAS registry number that uniquely identifies each chemical; the year the chemical’s HRL value is proposed to be established into rule; and the chemical’s volatility classification (low, moderate or high). HRL values are derived for different durations of exposure (acute, short‐term, subchronic, chronic and cancer). Also noted are the duration‐specific reference doses (RfD), the relative source contribution (RSC), and the default water intake rates (IR). Adverse health impacts and health endpoints from exposures to contaminants over the range of durations are also noted. Page 1 of 9
DRAFT Health Risk Limit (HRL) Rule Amendments (Provided for Discussion Purposes Only) Minnesota Department of Health Division of Environmental Health
Web Publication Date: August 16, 2010 DRAFT Proposed Amendments to the Health Risk Limit (HRL) Rule for Groundwater Contaminants (Minn. Rules Part 4717.7860) 4717.7860 HEALTH RISK LIMITS TABLE [For text of subps 1 to 3, see M.R.] Subp. 3a. Acetochlor ESA: CAS number: 187022‐11‐3 Year Proposed: 2010 Volatility: Nonvolatile Acute Short‐Term HRL (ug/L) ND 600 RfD (mg/kg‐
‐‐ 0.37 day) RSC ‐‐ 0.5 SF (per ‐‐ ‐‐ mg/kg‐day) ADAF or ‐‐ ‐‐ AFlifetime Intake Rate ‐‐ 0.289 (L/kg‐day) Endpoints ‐‐ Thyroid (E) Subchronic 600 0.23 Chronic 300 0.075 Cancer NA ‐‐ 0.2 ‐‐ 0.2 ‐‐ ‐‐ ‐‐ ‐‐ ‐‐ ‐‐ 0.077 0.043 ‐‐ Thyroid (E) Thyroid (E) ‐‐ Page 2 of 9
DRAFT Health Risk Limit (HRL) Rule Amendments (Provided for Discussion Purposes Only) Minnesota Department of Health Division of Environmental Health
Web Publication Date: August 16, 2010 Subp. 3b. Acetochlor OXA: CAS number: 184992‐44‐4 Year Proposed: 2010 Volatility: Nonvolatile Acute Short‐Term Subchronic Chronic HRL (ug/L) ND 200 200 100 RfD (mg/kg‐
‐‐ 0.12 0.077 0.026 day) RSC ‐‐ 0.5 0.2 0.2 SF (per ‐‐ ‐‐ ‐‐ ‐‐ mg/kg‐day) ADAF or ‐‐ ‐‐ ‐‐ ‐‐ AFlifetime Intake Rate ‐‐ 0.289 0.077 0.043 (L/kg‐day) Endpoints ‐‐ Thyroid (E) Thyroid (E) Thyroid (E) Subp. 3c. Acetone: CAS number: 67‐64‐1 Year Proposed: 2010 Volatility: Moderately volatile Acute Short‐Term Subchronic Chronic HRL (ug/L) ND 9,000 8,000 4,000 RfD (mg/kg‐
‐‐ 5.0 3.0 0.90 day) RSC ‐‐ 0.5 0.2 0.2 SF (per ‐‐ ‐‐ ‐‐ ‐‐ mg/kg‐day) ADAF or ‐‐ ‐‐ ‐‐ ‐‐ AFlifetime Intake Rate ‐‐ 0.289 0.077 0.043 (L/kg‐day) Endpoints ‐‐ Renal (kidney) Renal (kidney) Renal (kidney) system system, system, hematological hematological (blood) system (blood) system [For text of subps 4 to 8, see M.R.] Page 3 of 9
DRAFT Health Risk Limit (HRL) Rule Amendments (Provided for Discussion Purposes Only) Cancer NA ‐‐ ‐‐ ‐‐ ‐‐ ‐‐ ‐‐ Cancer NA ‐‐ ‐‐ ‐‐ ‐‐ ‐‐ ‐‐ Minnesota Department of Health Division of Environmental Health
Subp. 8a. Dichlorodifluoromethane: CAS number: 75‐71‐8 Year Proposed: 2010 Volatility: Highly Volatile Acute Short‐Term HRL (ug/L) ND ND RfD (mg/kg‐
‐‐ ‐‐ day) RSC ‐‐ ‐‐ SF (per ‐‐ ‐‐ mg/kg‐day) ADAF or ‐‐ ‐‐ AFlifetime Intake Rate ‐‐ ‐‐ (L/kg‐day) Endpoints ‐‐ ‐‐ Subp. 8b. 1,1‐Dichloroethene: CAS number: 75‐35‐4 Year Proposed: 2010 Volatility: Highly volatile Acute Short‐Term HRL (ug/L) ND ND RfD (mg/kg‐
‐‐ ‐‐ day) RSC ‐‐ ‐‐ SF (per ‐‐ ‐‐ mg/kg‐day) ADAF or ‐‐ ‐‐ AFlifetime Intake Rate ‐‐ ‐‐ (L/kg‐day) Endpoints ‐‐ ‐‐ Web Publication Date: August 16, 2010 Subchronic ND ‐‐ Chronic 700 0.15 Cancer NA ‐‐ ‐‐ ‐‐ 0.2 ‐‐ ‐‐ ‐‐ ‐‐ ‐‐ ‐‐ ‐‐ 0.043 ‐‐ ‐‐ None ‐‐ Subchronic 200 0.090 Chronic 200 0.046 Cancer NA ‐‐ 0.2 ‐‐ 0.2 ‐‐ ‐‐ ‐‐ ‐‐ ‐‐ ‐‐ 0.077 0.043 ‐‐ Hepatic (liver) system Hepatic (liver) system ‐‐ [For text of subps 9 to 12, see M.R.] Page 4 of 9
DRAFT Health Risk Limit (HRL) Rule Amendments (Provided for Discussion Purposes Only) Minnesota Department of Health Division of Environmental Health
Web Publication Date: August 16, 2010 Subp. 12a. Ethylbenzene: CAS number: 100‐41‐4 Year Proposed: 2010 Volatility: Highly volatile Acute Short‐Term Subchronic Chronic Cancer HRL (ug/L) ND 50 50 (2) 50 (2) NA RfD (mg/kg‐
‐‐ 0.075 (2) (2) ‐‐ day) RSC ‐‐ 0.2 (2) (2) ‐‐ SF (per ‐‐ ‐‐ ‐‐ ‐‐ ‐‐ mg/kg‐day) ADAF or ‐‐ ‐‐ ‐‐ ‐‐ ‐‐ AFlifetime Intake Rate ‐‐ 0.289 (2) (2) ‐‐ (L/kg‐day) Endpoints ‐‐ Hepatic (liver) Hepatic (liver) Hepatic (liver) ‐‐ system, renal system, renal system, renal (kidney) (kidney) (kidney) system system system Subp. 12b. Ethylene glycol: CAS number: 107‐21‐1 Year Proposed: 2010 Volatility: Nonvolatile Acute Short‐Term Subchronic Chronic Cancer HRL (ug/L) 4,000 4,000 2,000 2,000 NA RfD (mg/kg‐
0.76 0.76 0.72 0.50 ‐‐ day) RSC 0.2 0.2 0.2 0.2 ‐‐ SF (per ‐‐ ‐‐ ‐‐ ‐‐ ‐‐ mg/kg‐day) ADAF or ‐‐ ‐‐ ‐‐ ‐‐ ‐‐ AFlifetime Intake Rate 0.043 0.043 0.077 0.043 ‐‐ (L/kg‐day) Endpoints Developmental Developmental Renal (kidney) Renal (kidney) ‐‐ system, system, developmental developmental Page 5 of 9
DRAFT Health Risk Limit (HRL) Rule Amendments (Provided for Discussion Purposes Only) Minnesota Department of Health Division of Environmental Health
Web Publication Date: August 16, 2010 Subp. 12c. Metolachlor and s‐Metolachlor CAS number: 51218‐45‐2; 87392‐12‐9 Year Proposed: 2010 Volatility: Nonvolatile Acute Short‐Term Subchronic Chronic HRL (ug/L) 400 400 300 300 (3) RfD (mg/kg‐
0.24 0.24 0.097 (3) day) RSC 0.5 0.5 0.2 (3) SF (per ‐‐ ‐‐ ‐‐ ‐‐ mg/kg‐day) ADAF or ‐‐ ‐‐ ‐‐ ‐‐ AFlifetime Intake Rate 0.289 0.289 0.077 (3) (L/kg‐day) Endpoints Developmental Developmental None None Subp. 12d. Metolachlor ESA: CAS number: 171118‐09‐5 Year Proposed: 2010 Volatility: Nonvolatile Acute Short‐Term Subchronic Chronic HRL (ug/L) ND ND 4,000 800 RfD (mg/kg‐
‐‐ ‐‐ 1.7 0.17 day) RSC ‐‐ ‐‐ 0.2 0.2 SF (per ‐‐ ‐‐ ‐‐ ‐‐ mg/kg‐day) ADAF or ‐‐ ‐‐ ‐‐ ‐‐ AFlifetime Intake Rate ‐‐ ‐‐ 0.077 0.043 (L/kg‐day) Endpoints ‐‐ ‐‐ Hepatic (liver) Hepatic (liver) system system Page 6 of 9
DRAFT Health Risk Limit (HRL) Rule Amendments (Provided for Discussion Purposes Only) Cancer NA ‐‐ ‐‐ ‐‐ ‐‐ ‐‐ ‐‐ Cancer NA ‐‐ ‐‐ ‐‐ ‐‐ ‐‐ ‐‐ Minnesota Department of Health Division of Environmental Health
Web Publication Date: August 16, 2010 Subp. 12e. Metolachlor OXA: CAS number: 152019‐73‐3 Year Proposed: 2010 Volatility: Nonvolatile Acute Short‐Term Subchronic HRL (ug/L) ND 3,000 3,000 (2) RfD (mg/kg‐
‐‐ 1.7 (2) day) RSC ‐‐ 0.5 (2) SF (per ‐‐ ‐‐ ‐‐ mg/kg‐day) ADAF or ‐‐ ‐‐ ‐‐ AFlifetime Intake Rate ‐‐ 0.289 (2) (L/kg‐day) Endpoints ‐‐ None None [For text of subps 13 and 14, see M.R.] Subp. 14a. Perfluorobutane sulfonate (PFBS): CAS number: 375‐73‐5 Year Proposed: 2010 Volatility: Nonvolatile Acute Short‐Term Subchronic HRL (ug/L) ND ND 9 RfD (mg/kg‐
‐‐ ‐‐ 0.0042 day) RSC ‐‐ ‐‐ 0.5 SF (per ‐‐ ‐‐ ‐‐ mg/kg‐day) ADAF or ‐‐ ‐‐ ‐‐ AFlifetime Intake Rate ‐‐ ‐‐ 0.245 (L/kg‐day) Endpoints ‐‐ ‐‐ Hepatic (liver) system, hematological (blood) system, renal (kidney) system Chronic 800 0.17 Cancer NA ‐‐ 0.2 ‐‐ ‐‐ ‐‐ ‐‐ ‐‐ 0.043 ‐‐ None ‐‐ Chronic 7 0.0014 Cancer NA ‐‐ 0.2 ‐‐ ‐‐ ‐‐ ‐‐ ‐‐ 0.043 ‐‐ Hepatic (liver) system, hematological (blood) system, renal (kidney) system ‐‐ Page 7 of 9
DRAFT Health Risk Limit (HRL) Rule Amendments (Provided for Discussion Purposes Only) Minnesota Department of Health Division of Environmental Health
Web Publication Date: August 16, 2010 Subp. 14b. Perfluorobutyrate (PFBA): CAS number: 375‐22‐4 Year Established: 2010 Volatility: Nonvolatile Acute Short‐Term Subchronic Chronic Cancer HRL (ug/L) ND 7 7 (2) 7 (2) NA RfD (mg/kg‐
‐‐ 0.0038 (2) (2) ‐‐ day) RSC ‐‐ 0.5 (2) (2) ‐‐ SF (per ‐‐ ‐‐ ‐‐ ‐‐ ‐‐ mg/kg‐day) ADAF or ‐‐ ‐‐ ‐‐ ‐‐ ‐‐ AFlifetime Intake Rate ‐‐ 0.289 (2) (2) ‐‐ (L/kg‐day) Endpoints ‐‐ Hepatic (liver) Hepatic (liver) Hepatic (liver) ‐‐ system; system; system; Thyroid (E) Thyroid (E) Thyroid (E) [For text of subps 15 to 18, see M.R.] Subp. 18a. Toluene: CAS number: 108‐88‐3 Year Proposed: 2010 Volatility: Highly volatile Acute Short‐Term Subchronic Chronic Cancer HRL (ug/L) ND 200 200 (2) 200 (2) NA RfD (mg/kg‐
‐‐ 0.22 (2) (2) ‐‐ day) RSC ‐‐ 0.2 (2) (2) ‐‐ SF (per ‐‐ ‐‐ ‐‐ ‐‐ ‐‐ mg/kg‐day) ADAF or ‐‐ ‐‐ ‐‐ ‐‐ ‐‐ AFlifetime Intake Rate ‐‐ 0.289 (2) (2) ‐‐ (L/kg‐day) Endpoints ‐‐ Immune Immune Immune system, ‐‐ system, system, nervous system nervous system nervous system [For text of subps 19 to 23, see M.R.] Page 8 of 9
DRAFT Health Risk Limit (HRL) Rule Amendments (Provided for Discussion Purposes Only) Minnesota Department of Health Division of Environmental Health
Subp. 23a. Xylenes: CAS number: 1330‐20‐7 Year Established: 2010 Volatility: Highly volatile Acute HRL (ug/L) 800 RfD (mg/kg‐
1.2 day) RSC 0.2 SF (per ‐‐ mg/kg‐day) ADAF or ‐‐ AFlifetime Intake Rate 0.289 (L/kg‐day) Endpoints Nervous system Web Publication Date: August 16, 2010 Short‐Term 300 0.50 Subchronic 300 (2) (2) Chronic 300 (2) (2) Cancer NA ‐‐ 0.2 ‐‐ (2) ‐‐ (2) ‐‐ ‐‐ ‐‐ ‐‐ ‐‐ ‐‐ ‐‐ 0.289 (2) (2) ‐‐ Nervous system Kidney system; Nervous system Kidney system; Nervous system ‐‐ [For text of subps 24, see M.R.] REPEALER. Minnesota Rules, part 4717.7500, subparts 3, 3a, 6a, 8, 14, 25, 36, 39a, 40a, 41, 43, 46, 50, 52, 52a, 61, 65, 68, 70, 77a, 78b, 79, 80a, 81a, 85, 88b, 89 are repealed. Notes: ‐ʺ symbol means not relevant. ʺNAʺ means not applicable. ʺNDʺ means not derived due to absence or paucity of toxicity information. ʺNoneʺ means not applicable for inclusion in the health risk index. The following explanations in subitems (1) to (3) apply where noted: (1) The acute HRL value is less than the calculated HRL. To be protective of acute exposures, the HRL is set equal to the acute HRL value. (2) The short‐term HRL value is less than the calculated HRL. To be protective of short‐
term exposures, the HRL is set equal to the short‐term HRL value. (3) The subchronic HRL value is less than the calculated HRL. To be protective of subchronic exposures, the HRL is set equal to the subchronic HRL value. Environmental Health Division Health Risk Assessment Unit 651‐201‐4899 [email protected]
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DRAFT Health Risk Limit (HRL) Rule Amendments (Provided for Discussion Purposes Only)

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