LIFE SCIENCE TECHNOLOGIES
Produced by the Science/AAAS Custom Publishing Office
NEW PRODUCTS: TISSUE ANALYSIS
Stem Cell Counting Technology
Since the beginnings of mammalian tissue stem cell biology, counting has been
the bane of both basic research and clinical stem cell studies. Biomarkers, such as
CD34 and CD133, do not identify tissue
stem cells with sufficient specificity for
counting them. Asymmetrex’s AlphaSTEM
technology, developed with AlphaSTAR
Corporation, provides precise determinations of the number, viability, and selfrenewal pattern (asymmetric versus symmetric) of stem cells in complex tissue cell
preparations, including both research and
medical specimens. AlphaSTEM technology uses computer simulation to extract
tissue stem cell properties from specially
prescribed serial culture data. The AlphaSTEM tissue stem cell counting technology has many exciting applications,
including determining the number of stem
cells in experimental samples, determining the stem cell dose for transplantation
treatments, identifying agents that can
improve the vitality of transplanted tissue
stem cells, and identifying agents that are
toxic to tissue stem cells.
Asymmetrex
For info: 617-990-6819
www.asymmetrex.com
Cancer Stem Cell Identification Kit
The new AldeRed ALDH Detection Kit
is designed for identifying and isolating
cancer stem cells. The AldeRed reagent
is used to label cancer stem cells with a
red fluorescent dye, making it possible to
distinguish cancer stem cells in live cell
populations where specific identification
was previously impossible. Aldehyde
dehydrogenase (ALDH), a cancer stem
cell marker enzyme, causes the AldeRed reagent to fluoresce in the far-red
spectrum, allowing the cancer cells to
be identified and isolated with concurrent use of green fluorescent cell lines,
transgenic animals, and reporter assays.
Previous ALDH reporters exhibited green
fluorescence, which made it difficult to
identify positive cells in an otherwise
green fluorescent background.
EMD Millipore
For info: 800-645-5476
www.emdmillipore.com/stemcells Monoclonal Antibody
Pathology Imaging System
The Vectra 3 is an automated, highthroughput quantitative pathology
imaging system. The system’s new
seven-color multiplexing and visualization capabilities are designed to enable
pathologists and oncologists conducting research to gain a deeper level of
understanding of disease mechanisms
related to new cancer immunotherapy
approaches. The system visualizes,
analyzes, quantifies, and phenotypes
immune cells in situ in formalin-fixed
paraffin-embedded (FFPE) tissue sections. It incorporates 10x whole slide
imaging and the Phenochart whole slide
viewer, allowing researchers to annotate and navigate slides with interactive
interfaces to better identify regions of
interest for detailed multispectral acquisition. The multiplexing capability enables identification and quantification of
multiple biomarkers and reveals spatial
context within a digital workflow to assist researchers with better, faster decisions. Combined with PerkinElmer’s
inForm image analysis software, which
automatically identifies and quantifies
cell populations in tissue, the Vectra 3
system provides researchers the power
of multiplexed biomarker imaging and
quantitative analysis within a familiar
digital workflow.
PerkinElmer
For info: 877-754-6973
www.perkinelmer.com
A new immunohistochemistry (IHC)approved, human-specific, VISTA rabbit monoclonal antibody (mAb) is now
available for use in biomedical research.
VISTA (V-domain Ig suppressor of T-cell
activation, C10orf54, GI24, SISP1) is a
negative checkpoint control protein that
regulates T-cell activation and immune
response. Its role in negative checkpoint
control has made it an important target
in the field of tumor immunology, a field
that seeks to develop better therapeutic
options by dismantling the mechanisms
tumors use to generate and thrive in their
own immunosuppressive microenvironments. VISTA (D1L2G) XP Rabbit mAb
#64953 is validated using Cell Signaling
Technology’s rigorous standards, to recognize human VISTA in IHC and Western
blot research applications.
Cell Signaling Technology
For info: 877-616-2355
www.cellsignal.com
ChIP-Validated Antibodies
A new range of chromatin immunoprecipitation (ChIP)-validated antibodies are
now available. The use of high-quality
and specific ChIP-validated antibodies is
essential for the success of a ChIP assay.
The antibody must recognize and bind
to native protein that is bound to DNA.
Antibodies from other applications do
not always work well in ChIP. These topquality validated antibodies will give our
customers confidence in their protocols
and their results, safe in the knowledge
that a ChIP-validated antibody was at the
heart of their assay. Chromatrap currently
offers a range of ChIP kits for quantitative polymerase chain reaction (qPCR) or
sequencing and has now launched the
first nine antibodies in its validated antibody program, which are H3, RNA pol
II (S), RNA pol II (S5), H3K9me3, 5mC,
AcH3, AcH4, AR, and Sin3a. Chromatrap
validated antibodies are available in 100uL aliquots at a concentration of 1 mg/
ml, delivered overnight.
Chromatrap
For info: +44-1978-666222 www.chromatrap.com
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