In partnership with This booklet is brought to you by the AAAS/Science Business Office Call for applications 2010 Unesco-L’Oréal International Fellowships CO NTENTS Medicine and Disease 2 Common Passion for Common Good by Sean Sanders 4 Changing the Face of Science by Béatrice Dautresme and Walter Erdelen 6 Spreading the Seeds of Knowledge Ines Atmosukarto 8 Many Ways to Make a Difference Elena Bradatan 10 A Big Problem in a Small World Rehana Jauhangeer 12 Unlocking Nutrition’s Cancer-Prevention Potential Reema Fayez Tayyem 14 Personal Challenge, Shared Triumph Victoria Yavelsky 16 From Math Geek to Malaria Genetics Chemistry Pardis Sabeti 18 Continuing the Family Business Barno Sultanova 20 Unlocking Nature’s Pharmacopeia Farzana Shaheen 22 Believing in the Environment Stephanie Jenouvrier 24 Ministering to the Needs of a Nation The world needs science. Science needs women. Ecology Christine Ouinsavi 26 The Romance of Biodiversity Gisella Cruz Garcia 28 Tackling a Pesty Problem from Different Angles M. Laura Guichón 30 Virus Crime Scene Investigator Young women researchers in the Life Sciences have until June 30th 2009 to apply for the 2010 Unesco-L’Oréal For Women in Science International Fellowships. The Fellowships in support of research abroad are worth up to $40,000 each over a two-year period. Application forms for 2010 Fellowships will be available from March 2009 at: www.unesco.org/en/fellowships/loreal Marcia Roye 32 Finding the Right Balance Devi Stuart-Fox Life Sciences 34 Resilience in the Face of Stress Ahu Altinkut-Uncuoglu 36 Flourishing to the Extreme Prudence Mutowo 38 Folk Medicine for the 21st Century Mary George Kaileh Writers: Laura Bonetta, Emma Hitt, Virginia Gewin, Carol Milano Editor: Sean Sanders; Copy Editor: Robert Buck; Designer: Amy Hardcastle ii www.forwomeninscience.com © 2009 American Association for the Advancement of Science. All Rights Reserved. © 2009 American Association for the Advancement of Science. All Rights Reserved For an electronic version of this booklet, go to www.sciencecareers.org/lorealwis Common Passion for Common Good W hen we are growing up, we often imagine ourselves doing certain jobs: firefighter, sports star, lawyer, farmer, doctor. But the twists and turns that we encounter as we travel down life’s road often take us in very different directions from those we expected. Some of the women featured in this booklet knew that they wanted to be scientists. But many didn’t. They discovered their enjoyment of science through trial and error, through chance or fate. The road ahead is not always clear, but it is often more interesting and fun to make your own path, as these women have done, rather than follow the same road that everyone else is on. All of the young women profiled in this booklet are unique. They come from many countries around the world, from diverse cultures, and often from very different backgrounds. Each has faced obstacles—poverty, discrimination, political unrest—but all have overcome these difficulties, even growing stronger for having faced them. As there are differences, so are there similarities. These scientists, who have been kind enough to let us get a glimpse of who they really are, have many things in common: a passion for what they do, the desire to give back to their communities and help others less fortunate than themselves, and an inner strength that allows them to achieve their goals. Another common thread you will notice in these inspirational stories is that all of these women have a connection to the L’Oréal Foundation and UNESCO through a fellowship they received. On the facing page, you can learn more about how the L’Oréal Foundation and UNESCO support women in science. We here at Science and AAAS hope that you enjoy reading about the lives of these remarkable young women and are inspired by what they have achieved. All of these women have set out to make the world a better place; although they are still young, many have already achieved that goal. Each is exceptional in her own way, but they are also just like every young scientist: full of hope and passion, as well as some fear and uncertainty. Look at what they have done and know that you can do it, too. You can also find your passion, your path. And make a difference. THE UNESCO - L’ORÉAL INTERNATIONAL FELLOWSHIPS ENCOURAGING TALENT Fifteen UNESCO-L’ORÉAL International Fellowships are allocated each year to young women researchers in the life sciences, at the doctoral or postdoctoral level, whose promising projects have been accepted by a reputable institution outside their home country. Each Fellowship is worth a maximum of US$40,000 over two years. L’ORÉAL-UNESCO FOR WOMEN IN SCIENCE 2009: Almost 900 women in The Fellowship beneficiaries are geographically spread, three Fellows being selected from each of these five regions: Africa, Arab States, Asia and the Pacific, Europe and North America, and Latin America and the Caribbean. Since their creation, Fellowships have been awarded to 135 women from 71 countries. science will have been honored with awards or fellowships to support their careers since the creation of the L’OréalUNESCO partnership: Following a preselection process by the National Commissions for UNESCO, four candidatures from each country are forwarded to the Fellowship Section at UNESCO in Paris. The final selection of 15 beneficiaries is made by a UNESCO-L’ORÉAL Fellowship Selection Committee. L’ORÉAL-UNESCO AWARDS The program aspires to support the scientific vocations of young women, to give them the opportunity to build international networks in the scientific community, and to gain crucial experience that they can take back and share with others in their home countries. UNESCO-L’ORÉAL INTERNATIONAL FELLOWSHIPS • 57 Laureates from 27 countries • 135 Fellows from 71 countries L’ORÉAL NATIONAL FELLOWSHIPS • 670 Fellows in 48 countries Sean Sanders, Ph.D. Commercial Editor, Science www.unesco.org/en/fellowships/loreal © 2009 American Association for the Advancement of Science. All Rights Reserved. © 2009 American Association for the Advancement of Science. All Rights Reserved Changing the Face of Science Devi Stuart-Fox (see page 32) Founded by a scientist a century ago, L’Oréal created in 1998 the For Women in Science program of awards and fellowships in partnership with UNESCO. This program has already recognized hundreds of women in science and put down roots in nearly 90 countries— countries as far apart as Zimbabwe, Romania, Chile, Uzbekistan, and Indonesia. Now under the umbrella of the L’Oréal Corporate Foundation, the L’Oréal-UNESCO For Women in Science program supports this vast international community of talents that represents the future of science. Featured in this booklet are some of the UNESCO-L’Oréal International Fellows. The Fellowships awarded to these highly talented women are a vibrant reflection of the diversity found at all levels of modern science: diversity of research subjects, diversity of approaches, and diversity of the profiles of these young women who have in common a passion for science. These Fellowships not only help support the researchers to further their projects and their careers, but they also express the desire of the L’Oréal Corporate Foundation and UNESCO to put a different face on science—fulfilled, independent, and far from the clichés that have pursued women in science for so long. Besides supporting research projects around the world, the Fellowships have the secondary effect of drawing attention to these young scientists. By exposing young girls to real-world examples of scientific careers, the program contributes to the creation of role models who are indispensable to attracting new generations to careers in science. We hope that the enthusiasm and satisfaction expressed by the Fellows in our program will, in their turn, contribute to attracting young women who are hesitating to choose the path of science as a career. Béatrice Dautresme Executive Vice President, L’Oréal Managing Director, L’Oréal Corporate Foundation Logo L'Oréal Fondation d'entreprise BETC DESIGN / 2007 Reserved. © 2009 American Association for the Advancement of Science. All Rights Reserved In 1998, UNESCO and L’Oréal established the landmark For Women in Science partnership which aims to recognize and promote the role and significance of women in science. Each year, the joint program includes the prestigious L’Oréal-UNESCO Awards to five outstanding women researchers, and the UNESCO-L’Oréal International Fellowships for 15 promising young women at the beginning of their scientific careers. Awarded since 2000, the Fellowships permit women scientists at the doctoral and postdoctoral level to pursue their research in host laboratories outside their home countries. Importantly, the Awards and the Fellowships provide support and recognition for women from all regions of the world with awards made equally to the five regions—Africa, the Arab States, Asia and the Pacific, Europe and the USA, and Latin America. The UNESCO Science, Technology and Gender Report of 2007 emphasizes that “much talent is being wasted as girls turn away from S&T careers, and as women in S&T become discouraged by discriminatory treatment.” In research, women are still underrepresented, and this is particularly so at the decision-making level of science where research agendas are set. UNESCO is dedicated to eliminating all forms of discrimination and promoting equality between men and women. In addition, we believe women can bring about change for the better in science and that science needs women! An important starting point to addressing these inequalities and to promoting women’s role in science is to provide support for talented young women, from all corners of the globe, early in their careers. This booklet highlights the effectiveness of the UNESCO-L’Oréal International Fellowships in encouraging and enabling talented young women to pursue their passion for science. The stories of the young women highlighted here demonstrate the rich diversity of backgrounds, interests, and personalities that makes for an outstanding collection of potential leaders in science Rehana Jauhangeer throughout the world. As young women, they have a powerful voice (see page 10) to speak as effective and inspiring role models for others. Through the opportunities that the Fellowships provide for visibility, nationally and internationally, these young women develop their talents as advocates and public speakers for science and for women. The networks they are forming and the links with each other will be important components for their scientific work in the future. With each award, a new link is created in an ever-growing global network of women in science that is of great importance and relevance to both developed and developing countries. We believe that the talented recipients of the UNESCO-L’Oréal International Fellowships will use the training and experience gained during their fellowships to meet the challenges of using science for peace and sustainable development. Walter Erdelen Assistant Director-General for Natural Sciences UNESCO Photo Opposite Page (Bottom): Béatrice Dautresme (left) and Walter Erdelen (right) with fellowship award winner Gisella Cruz Garcia in 2007 (see page 26 for her story) © 2009 American Association for the Advancement of Science. All Rights Reserved d ea Spr In Indonesia, Ines worked on screening libraries of natural chemicals extracted from Indonesian plants that hosted a specific type of microorganism known as endophytic microbes. Her aim was to identify potentially ge Novel Compounds le d B y the time Ines Atmosukarto had finished high school, she had lived across the globe. Born in Romania, Ines lived as a child with her family in Algeria until the age of 13, when she moved to Jakarta, Indonesia, and finished high school there before leaving for the University of Adelaide in Australia. There she earned her undergraduate degree with first class honors and her Ph.D. in biochemistry and genetics. She returned to Indonesia in 2001 to try to stimulate research and development in the local biotechnology sector. Having been exposed to so many cultures, Ines had become passionate about sharing what she had learned and trying to expand scientific ties between Indonesia and other countries. “Research in Indonesia has been challenging, and I realized that the best approach would be to strengthen my international network with the aim of eventually fostering and facilitating strong links with Indonesia,” she says. w i S e e ds of K e h t no g n called Lipotek, based at the Australian National University in Canberra, where she currently oversees the development and testing of novel and innovative approaches to vaccine development. The first product, which could act as a preventative agent and therapy for an aggressive form of skin cancer, is expected to be tested for the first time on humans in early 2009. Strength and Support novel compounds for the pharmaceutical and agricultural industry while at the same time showing that the biological diversity of Indonesia could hold potentially exciting molecules and therefore should be better protected from deforestation. In 2004, Ines received the UNESCO-L’Oréal Fellowship which enabled her to conduct research at Montana State University in the United States for several months, with Gary A. Strobel, an acclaimed expert in the methods of harvesting novel compounds from microbes living symbiotically within plants. Ines returned to Indonesia to apply her new-found skills and to pass those skills on to other scientists. While there, Ines also helped establish an Indonesian Women in Science fellowship program with L’Oréal Indonesia and UNESCO, and a science mentoring program for young girls. Ines credits her family, especially her Romanian mother Ionica, as being a great source of strength. “My mother has been relentless in helping me deal with the extremely difficult task of balancing my family and professional life,” helping to care for her now 10-year-old daughter living in Jakarta. “Ines has turned into a tree with two deep roots, stemming from two different cultures from which she gains wisdom and strength,” says Ionica about the oldest of her three daughters. Inez Loedin of the Indonesian Institute of Sciences (currently at the International Rice Research Institute in the Philippines) has also served as a role model and men- tor for Ines. “Ines has a passion for science and her work,” her mentor says. “She always tried to make the best of the available facilities, overcoming limitations, such as faulty equipment, and finding alternatives when necessary. She also networked with scientists in more developed countries to help support her work, and was very good at motivating and encouraging the young undergraduate students that entered her lab.” No Limits Ines’s advice to young women—“which I received from my mother and will pass on to my daughter”—is that there is no limit to what you can achieve as long as you set your mind to it. According to Ines, there may be times when one will feel disadvantaged by gender, age, race, or other factors, “but these should act as a further incentive to disprove all of the skeptics. The road will not be easy, but whatever you decide to do, it will be because it is your choice and not something that has been imposed on you by others.” Moving On by Starting Up The research experience gained in the United States led Ines to the establishment of a small, startup biotechnology company with the assistance of the Indonesian Institute of Sciences and funds from local and international investors. Her success with this company landed Ines a position as chief scientific officer at another startup, “Whatever you decide to do, it will be because it is your choice” © 2009 American Association for the Advancement of Science. All Rights Reserved. Sticking with the Children Many Ways to Make a Difference After completing her fellowship in Belgium and moving back to Romania, Elena said she found the benefit of the UNESCO-L’Oréal Fellowship to be enormous. Her professional skills had become more honed, and she was able to interview at many of the top institutions in Romania. However, Elena says she also found a health system still in financial and organizational distress and one that could not guarantee proper treatment for sick children with cancer, “to such an extent that it was difficult psychologically for me to continue to work in pediatric oncology.” Elena therefore directed her interests to pediatric allergy and immunology and about a year later found a position at the Centre Hospitalier Régional (CHR) de Namur, in Belgium, to accompany her husband, a veterinarian who took a research position in Liege, Belgium. “I think research is extremely interesting but now my work is mainly clinical because I love interacting with people, especially children,” she notes. An Uncommon Will A s a young girl growing up in Romania, Elena Bradatan decided early on to follow in the footsteps of her mother, a pediatrician, who in Elena’s opinion had a very interesting career. Her grandparents also encouraged her interest in science by giving her a chemistry set one year, which she played with all summer long. Several years later, Elena began working as a research assistant in the Saint Maria Pediatric Hospital in Iasi, Romania, with the goal of attaining a Ph.D. in medicine at Iasi’s Medical University. “While I was doing my oncology internship service, I spent a large part of my internship in pediatrics, and what affected me most were the faces of the suffering children who could not be treated because of the severe side effects of the chemotherapy,” she says. Throughout her career, Elena says she has been supported by her husband and also her two mentors, Stela Gotia, professor of pediatrics, and Ingrid Miron, chief of the pediatric hematology oncology service at the l’Hôpital Universitaire des Enfants de Iasi Roumanie. “These are two female personalities with remarkable charisma that I especially admire,” she says. “Elena was indeed one of the inspiring interns that we had in the pediatric oncology and hematology ward,” says Miron of her former student. “She really had a special way of dealing with sick children and demonstrated both technical and human skills when working here.” Miron also points out that Elena does not quit easily and has an uncommon will for surpassing difficulties, and that this has likely helped her build her career. Elena encourages women interested in a scientific career to stay positive and “hold in their mind an image of their conquest. Although the work is serious and rigorous, more than one might imagine, it offers such joy.” Preventing Side Effects One of the most devastating effects of many types of chemotherapy is the way in which it destroys white blood cells, which protect against infection. As part of her doctoral thesis, Elena wanted to try to address this problem using certain blood growth factors, which can stimulate the production of blood cells and combat this effect. Making use of the UNESCOL’Oréal Fellowship she was awarded in 2004, Elena was able to work with researchers in Belgium, at the Saint Luc University Clinic of the Catholic University of Louvain. There she helped to identify the best dose of blood growth factors that could be administered in children receiving chemotherapy. Specifically, she evaluated whether blood growth factor support could be given at half the dose in select patients and still prevent side effects from chemotherapy. “These findings have been taken into consideration by my Romanian colleagues who now use this new dosage with more confidence,” Elena says. Her desire to carry out this research was fueled in part by conditions in her homeland of Romania, where the communist regime ended in 1989, but the infrastructure of health care and health insurance still had not been established. “Obtaining this type of treatment was difficult in my country at the time, and for me, this research was a way to contribute.” © 2009 American Association for the Advancement of Science. All Rights Reserved. “I love interacting with people, especially children.” A Big Problem Initial Inspirations “I have always been fascinated by science,” Rehana says. “My high school chemistry teacher inspired me and was my role model—she would tell us to walk along the corridor wearing our lab coats—saying that one day this would be our uniform as scientists.” After high school, Rehana began working in the central health laboratory at the Victoria Hospital in Mauritius. She then moved to London to begin work on her Master’s and Ph.D. degrees at the University of Westminster under the supervision of Pamela Greenwell, Dave Perry, and Mike Wren. “Rehana gave up many things to come to study in the UK including her job, her family ties, and her lifestyle,” Greenwell remembers. “She immediately found a job to support herself, working in the university during weekdays and on weekends, then in a private laboratory at night. She did this for five years, and never complained, and she always had endless patience with students working with her,” she says. Now Rehana works as a postdoctoral researcher at the clinical immunology department at the University College London Hospital. There, she works with Marlene Swana, David Isenberg, and eminent scientist Ivan Roitt, whose seminal work in 1956 helped establish the previously unknown role of autoimmunity in human disease. “I have always been fascinated by science.” in a Small World M auritius, a small island located in the Indian Ocean off the eastern coast of Africa, is a popular paradise-like travel destination. It also has one of the highest incidences of type 2 diabetes in the world. About one-quarter of the 1.3 million strong multiethnic population has type 2 diabetes or is at high risk of developing the disease. Of those, many will ultimately develop blindness, kidney failure, and/or foot complications, a leading cause of amputation. Rehana Jauhangeer grew up in the midst of this escalating problem, which affects not only people in her homeland, but also more and more of the world’s population. Rehana is now working to pursue ways to combat the effects of this disease. She studies defects in the immune system of patients with diabetes which make them susceptible to the bacteria that invade ulcers in the foot. Specifically, she has developed a method for rapidly detecting the presence of bacteria in these ulcers. The test will help shorten treatment times, and may prevent foot amputation due to gangrene. 10 © 2009 American Association for the Advancement of Science. All Rights Reserved. Networking and Giving Back According to Rehana, so far in her scientific career, the receipt of the UNESCO-L’Oréal Fellowship has been her “best and biggest achievement.” When she was awarded the fellowship, she was honored with the task of presenting her project at the UNESCO headquarters in Paris in front of an audience made up of internationally renowned scientists, journalists, and diplomats. These efforts, she feels, have helped put Mauritius on the scientific map and have allowed her to attract more funding for her work. Since then, she has also had the opportunity to network with other scientists at international conferences, such as BioVision, held in Lyon each year, and has organized a workshop with the Mauritius Research Council that has brought together specialists in Mauritius who deal with the different aspects of diabetes treatment and its management. She has also been on a committee for the Global Scientific Challenges: Perspectives from Young Scientists conference organized by the International Council of Science, an umbrella organization of UNESCO. Transmitting the Passion Rehana serves as a visiting lecturer at the University of Westminster in the UK where she teaches biomedical sciences and molecular biology. In the future, Rehana would like to become more involved with applied research that will bring “real solutions in the form of therapies and better diagnosis of disease.” She says she also wants to be involved with other activities for the public understanding of science and find ways to attract the next generation into studying science. “I am a great advocate of mentoring and transmitting the passion for science,” she adds. “It is very important to have a mentor at the very beginning of your career and a person who would guide you to get on track for a successful and fruitful career in science.” She adds that “to achieve your ultimate goals, passion is essential.” 11 Unlocking Nutrition’s Cancer-Prevention Potential R eema Fayez Tayyem has diverse research interests, but her scientific pursuits have one common goal—a desire to uncover the hidden health benefits of nutrition. Her work has ranged from how to improve the nutritional qualities of mashrouh bread to quantifying the cancer-fighting ability of curcumin, the yellow pigment found in the curry and turmeric spices. To do so, she looks to see what her fellow Jordanians eat and what diseases they get. Nutritional Counseling Reema’s focus on Jordanian residents makes sense. It is a way to correlate existing data to help people in her local communities live healthier lives. For example, Reema translated her work into general nutritional education campaigns as well as nutritional counseling specifically for renal disease patients. In fact, her Ph.D. research led to a patent for the preparation of a medicinal supplement of arginine, an amino acid that helps relax blood vessels, which can allow patients with certain heart problems to exercise more easily. But Reema’s regional focus is also the result of having few existing resources to support scientific research at her disposal. Reema did not have a chance to study abroad during her postgraduate work at the University of Jordan—an experience she hoped would enable her to use more advanced research equipment and techniques that might foster new research ideas. Developing New Ways Securing Her Future When she heard of the UNESCO-L’Oréal Fellowship, she applied but did not expect to win the award. “I knew it would be very competitive with women from all over the world, so I was pleasantly surprised to win,” she says. In 2006, Reema traveled to the University of California at San Diego’s (UCSD) Nutrition Research Laboratory at the Moores Cancer Center, intent on making each moment of her six-month stay count because the mother of two didn’t know if she would have another opportunity to travel. “I learned as much in those six months as I did in four years of my Ph.D.,” she says. While there, she strengthened her populationbased study approach by developing new ways of analyzing the curcumin content in both turmeric itself as well as in a patient’s blood and urine. That confidence has helped her make difficult career decisions to balance her family responsibilities and work loads. “Many women have trouble moving forward after they receive their Ph.D. degree because the most critical demands of family and career occur during this same window of time,” she says. For example, only a few women proceed to be full professors at Jordanian universities. To better ensure her success, Reema had taken on many roles—such as head of the nutrition and dietetics department—to secure her academic future. Reema says her decision to step down from that administrative position has helped her focus on her research and find a better balance for her family. Forging Collaborations Interestingly, she says, she thought visiting the United States would give her access to information she didn’t have before. “I realized that while I did have access to equipment, I didn’t get any information that wasn’t already available on the Internet or in books. But I did get more experience and self-confidence,” she says. Reema says the biggest lesson was learning how to forge productive collaborations with other university researchers. “I feel more competitive with my male colleagues who often have greater opportunities to see how international collaborations can form,” she says. Since her fellowship, Reema’s publication list has grown by leaps and bounds as a result of collaborations. “When I went to UCSD, I was an assistant professor with only two papers published. I now have 12 papers published or in press and have been promoted to associate professor,” she says. The scale of Reema’s work has increased too. She is conducting clinical trials of curcumin’s cancer-prevention ability. She started a large study of 800 subjects with a mixture of different ethnic backgrounds to measure curcumin intake among Jordanian people to see if the amount that people eat is linked to whether they get cancer or not. Reema plans to continue studying how nutrition may prevent cancer. She recently got funding to study the dietary and lifestyle risk factors for a type of intestinal cancer among Jordanians. Reema hopes one day to acquire the instruments that will help use her population studies of disease risk to develop disease treatments. Until then, her work is a reminder that science is driven by ideas—not technology. “I feel more competitive with my male colleagues.” 12 © 2009 American Association for the Advancement of Science. All Rights Reserved. 13 Personal Challenge, Shared Triumph V ictoria Yavelsky is an ovarian cancer researcher focused on innovative methods for early detection and treatment of the disease, the fifth most common form of cancer. She is also a gynecological cancer survivor. When she first learned of the UNESCOL’Oréal Fellowship, Victoria believed her story would resonate with the grant’s mission to facilitate new research possibilities for deserving young women scientists. It did. Rising out of Disaster Victoria’s career path is no less than remarkable—particularly because it was, inadvertently, set in motion by the Chernobyl nuclear disaster. At the time, a pregnant Victoria was living in nearby Kiev in the Ukraine. She and her physician parents were recruited to help treat the Chernobyl victims. In just 48 hours, Victoria and her unborn son became victims too. They were exposed to high levels of radiation, which would change their lives. Victoria, a single parent, was urged to take her son, Alex, born underweight and with difficulty breathing, to a better climate after his birth. She decided to move to Israel because of her Jewish heritage. Despite the difficult move, Victoria first sought training as a nurse to earn the money necessary to pursue graduate training in molecular biology at Ben-Gurion University of the Negev in Israel. She completed a Master’s degree, but fell ill as she began her Ph.D. She soon learned that she had a gynecological malignancy—possibly a consequence of her radiation exposure. Once she recovered, Victoria chose to focus her dissertation research on the disease that almost killed her. Eagerly Investigating In 2003, Victoria won the UNESCO-L’Oréal Fellowship. Professionally, the collaborations gained through the award proved pivotal to her career. While her focus was always on ovarian cancer, she says the money allowed her to pursue her work in grander ways. “The fel- “My parents and son were pivotal in enabling my success ... 14 © 2009 American Association for the Advancement of Science. All Rights Reserved. lowship essentially enabled the globalization of my research so that I could work with the upper echelon of great scientific minds, which has had a lasting impact on my career and myself personally,” she says. In particular, collaborative work with German scientists Michael Pfreundschuh and Dieter Preuss, both oncologists at Saarland University Medical School in Homburg, facilitated her research efforts to identify cancer-specific antigens that prompt an immune system response—and therefore, could potentially be used as a diagnostic test of early-stage cancer. The work’s commercial potential was recognized and promoted by Gerald Chan, a US-based radiation biologist turned biotechnology investor who is one of many proponents of early cancer diagnostics as the best way to significantly increase cancer survival rates. Being introduced to ideas and techniques from collaborators around the world helped Victoria identify and study mechanisms for slowing the spread of cancer cells. In addition to her work as a researcher at Ben Gurion University of the Negev, Victoria is eagerly investigating ways to engineer antibody-producing cells, in collaboration with Leslie Lobel, as a senior investigator at a drug development company called Docoop Technologies in Israel. Emotional and Moral Support While the professional relationships that developed in recent years have shaped her career development, so have the more personal ones. “The fellowship also helped me forge many close professional relationships, in particular with other women scientists—including my graduate advisers, Michal Shapira and Marina Wolfson, and the current president of the university, Rivka Carmi—who offered me much-needed emotional and moral support to overcome the many obstacles in my path,” says Victoria. “My parents and son, too, were pivotal in enabling my success as they believed in me and supported my dreams.” The fellowship holds special significance for Victoria—perhaps because she could have benefited from her own research. “I think that there needs to be a greater focus on diseases of women, and in particular, the malignant diseases,” she says. Ovarian cancer, for example, is called the silent or whispering disease because its vague symptoms are often overlooked or misdiagnosed until it becomes more advanced. ‘Incentive for the Uphill Struggle’ In addition, Victoria says the fellowship emboldened her desire to overcome the worklife challenges that women pursuing a scientific career often face. “The L’Oreal fellowship is extremely important because it acknowledges that women, who typically raise children during the course of their careers, need an extra incentive for the uphill struggle they face to define and achieve their research goals,” she says. Victoria’s career success exemplifies that women scientists are able to achieve their goals despite the expected—and even unexpected—difficulties balancing a professional and personal life, and can turn that recognition into greater reward. as they believed in me and supported my dreams.” 15 Nurture Your Confidence From Math Geek to Malaria Genetics P ardis Sabeti did not set out to be an award-winning scientist and Harvard University professor of evolutionary biology. The self-described math “geek” planned to attend medical school to fulfill her lifelong dream of becoming a doctor. But her drive to excel combined with her insatiable desire to solve mathematical puzzles nurtured a groundbreaking research career. A Ph.D.’s Worth of Work In 2002, Pardis rocked the genetics world by developing an algorithm able to sift through the human genome to identify evidence of natural selection. Pardis’s relentless efforts have garnered her a wall of awards. The biology major graduated from Massachusetts Institute of Technology and won a Rhodes Scholarship to Oxford University. “I never chose to get a Ph.D., but before I knew it I had a Ph.D.’s worth of work simply by pursuing my interest in genetic diversity,” she says. She ultimately earned her Ph.D. in biological anthropology. In 2004, Pardis won the UNESCO-L’Oréal Fellowship, which, she says, inspired her career in unforeseen ways. “I didn’t initially understand how this fellowship would reverberate beyond my research endeavors,” she says. Exciting the Next Generation She recalls one moment that made her realize the award’s lasting impact. At the 2004 American Association for the Advancement of Science annual meeting, she spoke to a group of young girls who were interested in pursuing scientific careers. Pardis was stunned by the energy of these girls and their hunger for role models, and amused when they even asked for her autograph. “For me, the greatest impact of the L’Oréal fellowship was understanding how to interact with and excite the next generation,” she says. Pardis went one step further to encourage the next generation. She used her fellowship dollars to sponsor students—in particular, two girls from local high schools—to work in her lab. The girls’ contributions were so valuable that Pardis included them as co-authors on a recent high profile publication. “Those students were life-changing for me,” she says. “I was like a proud mother, taking pictures of their first data result or their first talk.” Most important, she says the experience got her excited about the prospect of becoming a professor. “I thought I was going to be a full-time clinical doctor in a hospital. Until then, I hadn’t thought about being a professor at a research institution,” she says. In 2006, Pardis became an assistant professor at Harvard University. At the same time she was asked to serve on the National Academy of Science’s Committee on Women in Science, Engineering and Medicine. As a young faculty member, Pardis is cautious about taking on too many roles outside of research, but felt strongly about promoting women in science. She was also honored as a “Rising Talent” at the Women’s Forum for the Economy and Society, an annual meeting of 1,200 leaders in politics, business, culture, and academia from over 70 countries who gather to discuss the major issues facing societies today. There, the discussion turned to advancing to the next career level—and how differently men and women view their readiness for tasks. “One speaker noted that women tend to stay within a safe zone, often accepting a job when they feel they are 150 percent ready,” she says, adding that she has also found that to be true. Pardis says one of the most important pieces of advice she can pass on to young women is that they nurture the confidence to sense when they are ready to take the next career step. Two Important Diseases Pardis’s bold research moves reveal her confidence. Her work in genetics and interest in medicine culminated in her discovery of several examples of how infectious diseases have shaped the genomes of regional populations. In her new research lab, she is embarking on projects to study two important infectious diseases in Africa, malaria and Lassa hemorrhagic fever. Together with malaria expert Dyann Wirth, she is investigating the rapid evolution of the malaria parasite genome. She is looking, for example, for genetic variations that allow malaria to resist current antimalaria drugs. The work will help identify potential vaccine and drug targets—and help detect drug resistance at an early stage. While Pardis may have originally intended to be on a different career path, her work has already made an impact, and her future research on malaria alone has the potential to help thousands of people who otherwise might die from the disease each year. “ I was like a proud mother, taking pictures of their first data result.” 16 © 2009 American Association for the Advancement of Science. All Rights Reserved. 17 On to Germany Continuing the Family Business When Barno started to study polymer chemistry, she realized that a wealth of new discoveries came from Germany. “Looking back in history, many discoveries in chemistry were due to German scientists—and so to study in Germany was my dream,” she says. Barno attended Tashkent State Pedagogical University in Uzbekistan’s capital of Tashkent. After completing her studies there in 1999, she joined the A.S. Sadykov Institute of Bioorganic Chemistry of the Academy of Sciences, also in Tashkent. At that time, she familiarized herself with the literature on bacterial cellulose, and in 2004 was awarded a fellowship to study at Hamburg University in Germany. In 2006, after returning to Uzbekistan and receiving support from her government, she was excited to learn of the UNESCOL’Oréal Fellowship she was to receive toward her doctoral studies. With this funding, Barno was able to return to Friedrich-Schiller University where she is currently working toward completing her Ph.D. by mid 2009. Proud Role Model A s the youngest child in her family living in Uzbekistan, Barno Sultanova grew up hearing about chemistry from her father, brother, and sister, all of whom were chemists. The family also lived in the apartment block that belonged to the Institute of Cellulose Chemistry and Technology of the Academy of Sciences, where her neighbors would discuss their research within earshot of the young girl. Seeing Beyond the Unpleasant It was no surprise, therefore, that Barno felt inspired and encouraged to enter the “family business,” deciding to study organic and polymer chemistry. Specifically, her interests led her to study a substance called bacterial cellulose and the ways in which it can be used as a dressing for wounds. Cellulose is found abundantly in nature, particularly in plants. Bacteria, when they collect together, also produce cellulose to make what is known as a “biofilm.” When protected by their biofilm, bacteria become much more resilient to attack from disinfectants and antibiotics than individual bacteria existing alone. Barno was interested in the idea that certain properties of bacterial cellulose make it a desirable wound covering. Bacterial cellulose allows oxygen and moisture to reach the damaged area and can also be made to contain antibiotics to help in the healing. Barno’s research is exploring the different properties of cellulose produced by strains of the Acetobacter xylinum bacterium and is trying to identify which forms work best for different types of wounds. Although she agrees that using bacterial products on wounds might be unpleasant to think about, she says the wound covering works well, and she hopes her final product will have “many medical and technical uses.” Barno has made time along the way to raise two children, a son and a daughter, with the support of an “understanding man as my husband.” Barno says she is especially proud to be a role model for her children. “This summer when I was on holiday at home, I asked my son what he wanted to be when he grew up. He wasn’t entirely sure, but he said he liked mathematics and physics, and respects chemistry because of me,” she says. “This made me very happy.” Perfecting Her Delivery Barno has not been easily deterred by challenges in her life. In 2004, she decided she needed to improve her English. She sought and won a scholarship to study at the Central Institute of English and Foreign Languages in Hyderabad, India. Recently, in April 2008, Barno made her first trip to the United States to attend the American Chemical Society national meeting and to deliver an oral presentation there. “From the beginning, Barno worked very hard to perfect her delivery in English, and overcome many organizational and financial problems to attend,” says Dieter Klemm, her professor at the Friedrich-Schiller University. “It was her first presentation at a large meeting, and she did really well.” Barno advises young women in science to try to seek a balance between work and family life, but to know that “you can achieve anything if you just have a dream.” Life can be difficult at times, especially for women who are expected to be many things to many people, she says, but “we just have to try to find our own form of internal motivation and overcome these difficulties.” “You can achieve anything if you just have a dream.” 18 © 2009 American Association for the Advancement of Science. All Rights Reserved. 19 Working with Peace of Mind Revealing Nature’s Pharmacopeia B y her own admission, Farzana Shaheen comes from a society with strong customs and limitations for women, where a woman’s success in science “requires much effort, hard work and dedication.” But Farzana has not let that deter her. Born in Rawalpindi, Pakistan, Farzana has pursued a single direction in her career with the precision of an archer’s arrow. She is a “crazy and great scientist, who is determined about her work, sometimes spending long hours in the lab to complete her experiments,” says Sohail Gagai, a guardian who has helped support her in her studies, living in Karachi, Pakistan. “She is not afraid of any obstacle in life, and she seems to love what she does,” he adds. Growing up in Pakistan, Farzana earned undergraduate and graduate degrees at the Quaid-i-Azam University, in the capital city of Islamabad. She then pursued her Ph.D. in natural product chemistry at the University of Karachi under the supervision of M. Iqbal Choudhary, graduating in March 2000. According to Farzana, Choudhary, along with other professors, was a great support to her as she tried to make a name for herself in such a male-dominated field. Plant Medicine Farzana’s research has sought to root out compounds in nature that may be used to treat human diseases. While working on her doctoral degree, Farzana identified potent substances from traditional medicinal plants that could potentially prevent convulsions in epilepsy. “So far, only preventive medicines exist for epilepsy, but none of them cures the underlying disorder and the disease prevails for the entire life of the patient,” she says. According to Farzana, the available antiepileptic drugs are also associated with severe side effects when used over the long term. She hopes that the compounds she has identified may provide an alternative treatment option for these patients. After graduating with her Ph.D. in 2001, Farzana was appointed as an assistant professor of organic chemistry at the H.E.J. Research Institute. The UNESCO-L’Oréal Fellowship she received allowed her to travel to the United Kingdom in 2005 to work with Arasu Ganesan at the University of Southampton. This was her first experience working abroad. “There I worked on many small projects and learned synthetic organic chemistry,” she says. During that time, Farzana was also able to synthesize some of the antiepileptic products that she had identified during her doctoral research, moving her research forward significantly. As it has a habit of doing, family life intervened at the time Farzana was about to travel abroad. She gave birth to her first child right before leaving for the University of Southampton. She credits her understanding husband Zahuri Abdul Rauf, who “allowed me to work there with peace of mind,” for helping her with this task. Now she continues to balance her career and family life, with her son, who is now four years old, as well as a one-year-old daughter. Combine and Conquer Recently, Farzana won a Fulbright Scholarship for 2008-2009 to work with Kit S. Lam at the University of California, Davis. Working with one of the foremost experts in the field, Farzana is learning advanced combinatorial chemistry, which describes the process of bringing together the active parts of different molecules to come up with the best and most effective combination. She is using these powerful and novel techniques to build a collection of agents that can be tested for possible use in treating a wide variety of diseases. To date, Farzana has one US patent, for a synthetic antiepileptic compound, and 35 publications in international journals under her belt. She also supervises six graduatelevel students at the H.E.J. Research Institute of Chemistry in Pakistan. Currently, Farzana is applying combinatorial chemistry techniques to identify molecules that can potentially stop cancer in its tracks. She plans to return home to Pakistan soon to apply what she has learned. According to Farzana, it is important to love what you do and think positively. “You can get your inspiration from thinking about the things you are doing for this world, and the benefits that may come from your research and discoveries.” “You can get your inspiration from things you are doing for this world.” 20 © 2009 American Association for the Advancement of Science. All Rights Reserved. 21 Believing in the Environment S ome people know what they want to do with their lives from a young age. But not Stephanie Jenouvrier. She had never envisioned she would someday help people realize the devastating effects that global climate change is having on the environment. “I never planned to be a researcher,” says Stephanie, currently a population ecologist at the Woods Hole Oceanographic Institute in the United States. “When I find something I am interested in, I just follow my feelings. That is what I have always done.” Visiting the Antarctic Stephanie got her first taste of research in high school, back in France where she grew up. Her biology teacher often organized trips to a nearby research center where students conducted small projects. “I had a really good experience and loved it,” recalls Stephanie. Because of that, she attended university to study biology, focusing on animal ecology—what seemed like a good fit for someone who had always loved the outdoors and animals. As part of her studies, Stephanie worked in national parks, monitoring the numbers of brown bears. Again, she loved that work. She applied to graduate school to work in the laboratory of Henri Weimerskirch, research director at the Center for Biology Research in Chizé, France. Her Ph.D. focused on how changes in climate affect sea birds living in Antarctica. Part of her research required visiting the French Antarctic territories for two- to three-month stretches to gather data. Global climate change is impacting many ecological processes all over the world, but the consequences seem to be particularly dramatic in the polar regions. their breeding colony on Antarctic islands, and whether they would breed, feed, nest, and so on. “Last time I went to the Antarctic I was responsible for following penguins. Our team would survey them for 24 hours, so sometimes my shift lasted until 4 o’clock in the morning,” she recalls. “It is very intense work, but I love that. It is so unique to spend a day observing penguins.” To be able to predict the fate of these animals Stephanie knew it would not be enough to merely observe them. She would need to join forces with experts in mathematical models. With support from a UNESCO-L’Oréal Fellowship, she was able to move to the United States to work with mathematicians at Woods Hole. The fellowship paid for part of her salary while she worked there and also allowed her to visit climate scientists working at the National Center for Atmospheric Research and the National Snow and Ice Data Center in Boulder, Colorado. “The fellowship allowed me to spend several weeks in Boulder,” says Stephanie. “Any biologist who studies the impact of climate change should have this kind of collaboration with climatologists.” Indeed the interaction and sharing of ideas with these scientists allowed Stepha- nie to use models of climate change to predict what would happen to emperor penguin populations if current trends in greenhouse gas emissions continue. “If I can provide scientific evidence that climate change affects populations of animals, I can convince people that it is important to do something about it,” she explains. Staying Flexible And she is well on her way to doing just that. The results she obtained while working in Woods Hole were recently published in the scientific journal, Proceedings of the National Academies of Science. They provide a dire warning. Stephanie’s work predicts that the number of emperor penguin “couples” will decline from 6,000 to 400 by the year 2100. Despite only being at the start of her career, Stephanie’s research is already having an impact. But success does not come without sacrifices. “My mother always asks me ‘When are you going to have children?’” she says with a laugh. “But it is not easy to have children while you are doing your Ph.D. and postdoctoral studies. You have to be able to travel and be flexible.” Still, she would not trade in her lifestyle for anything, at least not for now. “I have not been to the Antarctic in a year now and I hope to be able to go back soon,” she says. Observing Penguins Much of Stephanie’s work during those months consisted of catching birds to attach an identification ring on their leg, so that they could be tracked over time. She also monitored previously tagged birds to see when and where they would return to 22 © 2009 American Association for the Advancement of Science. All Rights Reserved. “It is so unique to spend a day observing penguins.” 23 Call to Service Ministering to the Needs of a Nation C hristine Ouinsavi always loved nature. But she never imagined that her fascination with plants would lead her to the highest levels of government in Benin, her native West African country. Christine received a UNESCO-L’Oréal Fellowship in 2007 for her postdoctoral studies. As she was finishing statistical analysis of her data, an unexpected request came: President Boni Yayi of the Republique of Benin invited her to join his new government. “He had been seeking highly educated women leaders who could help him build the country technically, economically, and politically. I was identified as one,” she learned. Following a meticulous selection process, Christine was named Minister of Primary Education, Literacy and National Languages. “It was an opportunity to reveal the ability of women to contribute to the management of state affairs, as well as a new experience and a chance to be useful to my country.” Deeply committed to girls’ education, Christine was involved in 2008 with a new mobile outreach: an educational program that tours rural districts where girls’ enrollment and attendance rates are low, and stresses to parents the importance of sending daughters to school. She believes that educating girls will improve their own wellbeing, and the prosperity of their families, communities, and country. Focus on Conservation A Global Organizer After secondary school, Christine enrolled at a local agricultural college, but soon realized that the courses offered “might not help me to be a researcher. My wish was to go as far as possible at school—to get the highest degree,” she recalls. She earned a Master’s in science at the University of Ibadan in Nigeria; a biotech training course at Ghana’s Forestry Research Institute persuaded her to focus on conservation of forest resources. “I believed that I could find new ways to help preserve the forests, and contribute to Benin’s national economy,” Christine says. Research for her Ph.D. in agronomy began in 2003 at Benin’s University of Abomey Calavi, on sustainable management of locust bean fruit, shea butter trees, and ronier palms. She hopes her work will eventually benefit both Benin’s plants and its citizens. “Rural people here rely on the sale or use of forest products to meet their daily needs,” Christine explains. Current harvesting methods put native trees at risk of overexploitation, lowered genetic diversity, and unsustainability. “Research on endangered tree species will help to conserve and reestablish plantations with high-yielding plants, and ensure a stable income source for the rural population.” “My first role as a minister was related to my skill as an educator and human resource manager,” she reflects. In October 2008, President Yayi reorganized his government, and appointed Christine as Minister of Trade and Industry—one of only four women at this level. “He wants me to use my managerial ability to organize women who sell at local markets, as well as those who are involved in internal and external trading, in order to make Benin’s commercial sector more professional and structured,” she summarizes. She attends important international gatherings, like December’s UN Conference on Trade and Development in Kenya. Despite a hectic schedule requiring frequent travel, “My wish was to go as far as possible at school.” 24 © 2009 American Association for the Advancement of Science. All Rights Reserved. Christine pursues her research as much as possible. She’s arranged to continue part of her lab work at the Africa Rice Center in Cotonou, and is a lecturer in agronomy at the University of Parakou. She served as president of the Benin National Commission for UNESCO in 2006, organizing and participating in such gatherings as the Regional Conference of the African National Commission of UNESCO. Encouraging Girls Christine finds her newest position “interesting, but quite different from scientific research. However, an educated woman who develops scientific and managerial capacity could easily succeed at this job. I would like to encourage girls to be interested in the sciences because I can state with certainty that a scientific woman is a complete one.” So far in her career, Christine is proudest of “being at the top—among the highest level women in the government. My dream is already partially realized,” she confides. What’s next? “Once my research project is complete, and after my experience in government, my goal is to attain a decisionmaking position in an international organization or institute, so I can be more useful as a woman leader,” Christine declares. 25 The Romance of Biodiversity J acques Cousteau converted her. Watching and admiring his documentaries as a child, “I always wanted to be a scientist,” says Gisella Cruz Garcia. Though the family lived in urban Lima, Peru, “I was different; I liked going to rural areas to see plants and nature.” A New Arrival Majoring in biology and ecology, Gisella graduated at the top of her class from Lima’s Universidad Nacional Agraria La Molina. She studied biodiversity along Peru’s Pacific coast, in the Amazon rain forest, and also in the Andes mountains. In 2001 Paul Peters, a Dutch student, arrived in a tiny Andean town to study medicinal plants. “He hardly spoke Spanish, only English. I was the only one who knew any English, and had to help him communicate with workers,” Gisella recalls. “Then the romance started. We’ve been together ever since!” She moved to the Netherlands in 2003, and married Paul, an agronomist. For her Master’s degree at Wageningen University, Gisella chose an unusual research combination: plant science and social science. Her work was published in the Journal of Ethnobiology & Ethnomedicine—a rare achievement at the Master’s level. Traditional Knowledge During her doctoral studies, Gisella received two prestigious summer fellowships that gave her the opportunity to learn essential methodologies and provided unique, unforgettable experiences. In 2007, she and eight other Ph.D. students spent two months with Bolivian Amazon tribes, “without electricity, bathing in the river, cutting firewood each day. We saw the relationship between people and environment, and their traditional knowledge about how to use plants passed from generation to generation, managing and preserving biodiversity.” Then in 2008, a European Science Foundation program took 15 Ph.D. and postdoctoral students from diverse backgrounds to Spain. “Archaeologists, biologists, geneticists, historians all tried to understand the dynamics of agriculture in traditional societies, from thousands of years ago up to now,” says Gisella. “I wanted to participate because, to know where we are going, it’s important to understand where we have come from.” Thanks to her UNESCO-L’Oréal Fellowship (2007-2009), says Gisella, “I can now carry out my [rice ecosystem biodiversity] research in Thailand! It’s going excellently. I’ve been on two long trips, to Thailand and the Philippines. In one village, I could identify, observe, and study “It’s not only about research, but also about performing in their society, being polite. 26 © 2009 American Association for the Advancement of Science. All Rights Reserved. other wild food plants in the rice landscape,” including water spinach, tamarind, and water lilies. Research on rice, the world’s most important crop, usually considers the plant in isolation, but often rice farmers depend on other nearby plants for food, fuel, or construction materials, and for medicinal uses. Importance of Being Polite As the only researcher in those Thai villages, where few speak English, Gisella had difficulty finding anyone to help with her research. But once she learned the culture, things grew easier. “Each country has its own ways and social norms. I have to adjust to that, starting from how you sleep [e.g., on the floor]. It’s not only about research, but also about performing in their society, being polite. I love it!” Gisella hopes her methodology is applicable in other places as well. Ultimately, she’d like to work for an international organization, sustaining biodiversity in developing countries. “It’s so important that research is not only on paper, but also that results are implemented according to needs of local people, [especially] poor farmers—for both their livelihood and their agriculture.” ‘Fight for Your Ideals’ Though most plant scientists are men, “it makes no difference to me,” Gisella asserts. If you like science, “do not be afraid! Try it,” she urges. “Do what you really like, put all your passion into it, and fight for your ideals. If you’re happy and you enjoy it, you’ll have more opportunities and motivation.” For women scientists, “It’s important to have someone who understands and supports your work,” Gisella acknowledges. Luckily, she and Paul have similar ideals and careers. Now an importer of organic, fair trade foods, he accompanies Gisella on Asian research trips. “I go with him to talk to villagers, farmers, and companies, to also support him in his work.” “Gisella thinks very creatively. She came up with amazingly innovative work for her Ph.D., because she was awarded this wonderful UNESCO-L’Oréal Fellowship,” says her supervisor, anthropologist Lisa Price, associate professor in Wageningen University’s Department of Social Sciences. “Her holistic approach is unique in agricultural research. She’s concerned not just about plants, but about the human element, applying it to people’s lives. She’s a wonderful role model for young women.” I love it!” 27 Tackling a Pesty Problem from Different Angles T he red-bellied beautiful squirrel lives up to its name. Sporting a blood-red underbelly it is a striking sight in anyone’s garden, and especially in the Pampas region of Argentina that surrounds the city of Buenos Aires. People living there had never seen a squirrel until 35 years ago. But there, the furry critter is also causing havoc. Biologist M. Laura Guichón has made it her mission to stop it in its tracks before it causes too much damage. ‘This Squirrel Was Everywhere’ This type of squirrel, which goes by the scientific name of Callosciurus erythraeus, is originally from Southeast Asia. It settled in Argentina in 1973 when a handful of animals escaped or were released from a garden where they were being kept as pets. Like many species of animals that are not native to a country, these squirrels have no natural predators and they multiply quickly. As they do, they ravage habitat and resources that native species—and people—rely upon. Laura became interested in the red-bellied beautiful squirrel while she was doing research for her Ph.D. She was spending a lot of time outdoors, studying a rodent called the coypu, which, unlike the squirrel, is native to Argentina. “When I was working in the field I could see this squirrel was everywhere and causing a lot of damage to trees, agriculture, and irrigation.” A Model of Invasion After her Ph.D., Laura started an independent project to study just how quickly the pesty squirrel was invading the countryside. She received a UNESCO-L’Oréal Fellowship, which allowed her to travel to England for one year to work with Patrick Doncaster at Southampton University—an expert at constructing mathematical models. “I was immediately keen to help her model the invasion process so that we could predict its future impacts and look for ways to control the spread,” says Doncaster. 28 © 2009 American Association for the Advancement of Science. All Rights Reserved. Together they created models of how the squirrel population might expand 18 years into the future under different scenarios for managing its spread. The results where published this year in the journal Ecography. “One goal of this work was to suggest ways to stop the squirrel population from spreading farther,” explains Laura. She credits the UNESCO-L’Oréal Fellowship with enabling her to work in a foreign country, gain expertise in a different area of research, and publish in a highly ranked international journal, all of which ultimately helped her obtain a permanent position as an independent researcher at Lujan University in Argentina. Talking to Pet Owners At her university, she has put together a small team of graduate and undergraduate students. Together they are monitoring the numbers and spread of red-bellied beautiful squirrels, studying their ecology and how they impact the environment, as well as evaluating the efficacy of different methods for managing spread. “She has the capacity now to target management actions against the squirrel, which will be of lasting benefit to the Buenos Aires province and beyond,” says Doncaster. According to Doncaster, Laura’s work is unique in that it combines biological research with something akin to “social work.” Because there are no native squirrels in the Pampas, people like to capture the squirrels to keep as pets and sometimes take them to different areas of the country. Such movements can greatly aid their spread. “Part of our work is to get information to the community by talking in schools or doing workshops,” explains Laura. “People need to understand that by moving the squirrel they are creating new pockets of invasion.” Value of Publicity Laura says that the fellowship has helped her work in an unexpected way. “When I got the fellowship, L’Oréal and UNESCO issued a press release. As a result many people in the country heard about my project. When I talk about my work they remembered hearing about someone who was working on the squirrel,” says Laura. “That is important for the public face to my project.” Laura is deeply committed to the work she is doing. And that commitment, she explains, is critical to being a successful scientist. “I think it is great to be a scientist, but you must have a passion for it because science is hard work and you have to make many compromises,” she says. One of the compromises she made was to postpone starting a family until she had a permanent position as a researcher. “But the profession also gives a lot of flexibility,” she adds. And she has taken advantage of it. These days she sometimes works from home, where she can spend time with her seven-month-old son … and watch the red-bellied beautiful squirrels outside her window. “I think it is great to be a scientist.” 29 Virus Crime Scene Investigator P eople are not the only ones to get sick from viruses. Sometimes viruses attack plants—and the results can be devastating. Take the geminiviruses, for example. These microbes have wiped out entire crops, causing millions of dollars worth of damage. Evidence of Guilt Advising Farmers “Members of my own family are farmers. My brother and his wife were affected by geminiviruses,” says Marcia Roye. “These viruses were first discovered in the 1970s, but until we started our research, little was known about them in Jamaica.” A team leader at the Biotechnology Center of the University of the West Indies, Mona in Kingston, Jamaica, Marcia has been studying Jamaican geminiviruses for nearly two decades. Her research is helping to find ways to stop the virus from spreading. Like crime scene investigators, Marcia and her graduate students find infected plants in fields and bring them back to the lab. There, they use molecular biology tools to identify the virus guilty of infection based on its genetic “fingerprint.” So far, they have identified 24 different types of geminivirus that cause havoc in Jamaica. They also discovered that new types of viruses are forming all the time. “Sometimes two different geminiviruses infect the same plant and exchange genetic material. They then become a new virus,” she explains. Geminiviruses infect many crops such as tomatoes, papaya, beans, and cabbage, to name a few. But some varieties of a particular crop—some kinds of tomatoes, for example—are resistant to infection. So, for each virus they have identified, Marcia’s team has determined precisely which varieties of crops it destroys. “We can help prevent infection by telling farmers what varieties of crops to plant and not to plant. Sometimes the farmers don’t listen though,” she says with a laugh. Marcia learned the molecular techniques necessary for studying geminiviruses during her Ph.D. studies. With a UNESCOL’Oréal Fellowship, she traveled in 2001 from Jamaica to the laboratory of plant virus expert Douglas Maxwell at the University of Wisconsin-Madison in the United States, where she conducted research. She brought back the methods she learned there; and today the work she and her graduate students are doing is known across the world, and her lab is part of a large international research network of laboratories studying geminiviruses. 30 © 2009 American Association for the Advancement of Science. All Rights Reserved. A Mother’s Rule Wherever There’s a Need Her achievements are inspiring young students in Jamaica to follow in her footsteps. “My story is similar to theirs—they can relate to that,” she says. “If they see I have done it, they know they can do it too.” Marcia grew up in a rural part of Jamaica, where few people go to university and even fewer ever meet scientists. “I don’t come from a rich family, but education was always very important. My mother would say ‘Even if fire is falling from the sky you are going to school,’” she recalls. Eventually, this passion for education led to university, where Marcia decided to study biochemistry. “Part of the attraction was that, with science, I thought I could help people in my community,” she explains. Working in a country like Jamaica provides many opportunities for making a difference. “I have had many opportunities to leave Jamaica and be a researcher in other countries, but the reason I have not left is that I want to have an impact on the next generation,” she explains. But there are also challenges. “At a place like Madison, if we needed a reagent, we would get it right away. Here, it can take up to two to three months,” she explains. Marcia’s attitude is that these kinds of obstacles can easily be overcome. “We have some problems with resources in Jamaica, but there are many ways to get around those problems.” She is also quick to take advantage of the expertise of other researchers. “When I read an interesting research paper I will e-mail the scientist who did the work to ask questions and sometimes I go to their lab,” she says. “They are always happy to help with what I want to do.” Marcia will soon turn her investigative skill to a new and challenging area of research: the virus that causes AIDS in people. “There is a lot of epidemiological data in Jamaica that tells how many people are infected with the human immunodeficiency virus, but there is still a lot to learn,” says Marcia. “That is what drives my research: where there is a need, I see what we can do.” “ Part of the attraction was that, with science, I thought I could help people in my ” community. 31 Finding the Right Balance From Ocean to Desert O ne of the things I am most proud of is the research I have produced, often under challenging circumstances. I am also proud of the balance I have achieved in terms of life experiences,” says Devi Stuart-Fox, a zoologist at the University of Melbourne in Australia. “I am ambitious, but I have never been completely single-minded about an academic career path. Other things are important to me.” Freedom to Travel Why the Brightest Colors? One of these things is the freedom to travel and to be exposed to different cultures. While she was doing her Ph.D. at the University of Queensland in Australia, studying variation in the color patterns of desert lizards, Devi joined an international scientific expedition surveying a mountain range in Borneo and also spent a month in Papua New Guinea teaching Papuan university students a course on wildlife conservation. “These were just opportunities that cropped up during my Ph.D. research and I took advantage of them,” says Devi. “I really enjoyed going to these places and working there. It is different from being a tourist.” It is no surprise that when it came to applying for a postdoc position in 2003, Devi started looking for opportunities outside of Australia. At the time she was interested in asking the question: How do animals use color to communicate with one another? One of the animals best known for its colors is, of course, the chameleon! And most of the world’s chameleon species are only found in Africa and Madagascar. Male chameleons are typically a shade of brown or green, but can switch in a flash to bright green, yellow, orange, or pink. Many biologists have long thought that chameleons gained this ability to change their skin color so that they could hide from predators. But Devi instead determined that, although color change is used for camouflage, this ability evolved primarily to allow chameleons to communicate. Male chameleons use the brightest colors to fend off other males or entice females. “Devi spent a lot of time in the field capturing animals, ultimately assembling a very large data set. She was able to get good sample sizes even on some species of chameleons that are quite rare,” says her postdoc adviser, ecologist Martin Whiting. The hard work paid off. Devi’s findings were published in a range of journals including the widely read American Naturalist and PLOS Biology, kicking off a flurry of media attention. Six Months in a Tent So Devi decided to go to the University of Witwatersrand in Johannesburg, South Africa. “Most Australian Ph.D. graduates go to the United States or Europe to do a postdoc, but I wanted to go somewhere different,” says Devi. “It may not have seemed the most strategic career move at the time but I was lucky to have an excellent mentor and that the research worked out, which opened up subsequent opportunities.” She received a UNESCO-L’Oréal Fellowship, which paid for her to study 21 different populations and species of South African dwarf chameleons, monitoring the changes in color patterns that each produced in the wild. “I spent at least six months in a tent and traveled very widely across the country to find chameleons,” says Devi. As a result of her research, Devi was able to land her current position as a lecturer in the Department of Zoology at the University of Melbourne and to receive grants to conduct her research. “Devi is an outstanding scientist,” says Whiting. “She has been highly successful and has already made a name for herself. She is well on her way to becoming a leader in the field.” “I really like the research I am doing and I like interacting with students,” says Devi. With her students she is now looking at how various animals—from Lake Eyre dragon lizards in the Australian desert to the dumpling squid—use different signals to communicate. “I am still doing a lot of field work with my students, but now I am seven months pregnant so it is getting hard to do,” she says with a laugh. Although work has been challenging at times, Devi knows that a greater challenge will be combining her life as a researcher with being a parent. “So far, research has been my life. I have other passions like cooking and hiking, but I spend most of my time working,” she says. “When I have children, I will have to take time off. I will have no choice but to develop a better lifework balance.” “I really like the research I am doing and I like interacting with students.” 32 © 2009 American Association for the Advancement of Science. All Rights Reserved. 33 R S esilience St r e s s Global Collaborations in the Face of ince high school, Ahu Altinkut-Uncuoglu knew she wanted to study biology and credits a favorite biology teacher for inspiring her to pursue her Bachelor’s, Master’s, and then Ph.D. at Istanbul University in Turkey. Nearly two decades later, Ahu is now an accomplished scientist with an impressive academic career, attempting in a very real way to help solve the problem of world hunger. Ahu has collaborated globally with researchers who have expertise in plant genetics. From 2000 to 2001, Ahu went to Colorado State University as a visiting scientist to work in the Department of Soil and Crop Science. Then, in 2003, she received support from the UNESCO-L’Oréal Fellowship which allowed her to pursue her postdoctoral research at the Institute of Evolution at Haifa University in Israel. During this time she also was awarded funding from two other prestigious fellowships, the International Plant Genetic Resources Institute Vavilov Frankel Fellowship and the Haifa University Research Authority Fellowship. While at Haifa University, Ahu was promoted to foreign senior researcher before returning to Turkey as a senior research scientist at the TÜBİTAK (Scientific and Technological Research Council of Turkey) Marmara Research Center in Gebze, just east of Istanbul. Kemal Kazan, now a plant science researcher at CSIRO Plant Industry in Brisbane, Australia, provided guidance for Ahu during her doctoral studies. He notes that he saw in her the same aspirations that he once had when he was a Master’s student in Turkey. “I think we both felt somewhat limited in our ability to acquire new knowledge, so we sought new opportunities elsewhere,” he says. The Work-Family Balance Kazan also points out that Ahu has done a “terrific job” in simultaneously managing her family life and a successful scientific career. Turkey is an open, secular society respecting human rights, but traditionally a woman is still expected to have children soon after marrying, and her husband’s career often takes priority in the family, notes Kazan. “Ahu has demonstrated that her family life could indeed go hand in hand with a successful scientific career.” Ahu, who has been married for nine years to “a highly supportive husband” and has a one-and-ahalf-year-old son, notes that the decision to have children depends on the priorities in one’s life. “I preferred to wait for some time to have children because I wanted to establish my career first so that I am able to spend as much time as possible with my child,” she says. “ Much success simply comes down to hard work. ” Stress Tolerance and Disease Resistance Even today, malnutrition remains a major contributor to the total global disease burden, and more than one-third of child deaths worldwide are due to undernutrition, according to the World Health Organization. Ahu’s research helps to provide a more stable food supply through the development of hardy crops able to withstand drought and disease. She uses plant biotechnology techniques to understand, at the molecular level, how plants can withstand harsh environmental conditions, such as drought, high salt levels, and certain diseases. Her laboratory is currently studying the wheat genome, with the hope of identifying genes and other characteristics that confer resistance to salt stress and a fungal infection called yellow rust disease. “As a result of our efforts, we aim to create tolerant, healthy, and disease-resistant plants to provide more food in a world with changing population and climate,” she says. 34 © 2009 American Association for the Advancement of Science. All Rights Reserved. Hard Work and Persistence Like the crops she studies, Ahu has displayed great resilience in the face of difficulties. “Even if she fails in some of her challenges, she never gives up. She learns from her past experiences and tries again,” Kazan says. Nermin Gözükirmizi, who was Ahu’s supervisor during her Master’s and Ph.D. programs, notes that Ahu was one of her best students “who knew what she wanted and how to achieve it.” She adds that with her deep intellectual ability, motivation, and ability to work both alone and with others, Ahu is likely to continue to succeed in her career. Ahu, who is now working as a deputy director for the TÜBİTAK Marmara Research Center Genetic Engineering and Biotechnology Institute, plans to continue doing innovative research, spread her knowledge in the area of plant biotechnology, and educate as many students as possible. She advises budding researchers seeking a career in the sciences to try to develop their knowledge in their area of interest and to focus on an appropriate target. “After that, much success simply comes down to hard work,” she says. 35 Flourishing to the Extreme her a series of detergents to test.” Some of the detergents degraded the DNA, but Prudence went to the library to research ways to improve the experiments and came up with the idea to include a stabilizing agent called EDTA. “We went on to use this DNA isolation approach in the lab, and it worked beautifully!” she says. Brutal Environments A s a child, Prudence Mutowo could be found playing in the grass under the blistering sun of her hometown of Mutare, Zimbabwe, gazing at tiny insects, such as lady birds and red ants, in the palm of her hand. “Regardless of their minuscule size, they had perfectly formed legs and little heartbeats you could see as you held the insects,” she says. Her fascination with these petite life forms led her to study biology in high school in Zimbabwe, where classes on cell structure and function further sparked her interest in even smaller life forms. What? Girls Don’t Do Science? You Can’t Scare Her However, in high school in Zimbabwe, Prudence says, the common attitude was that “girls don’t do science.” Rather than letting this deter her though, it had the opposite effect and brought out the rebel in her: “That was it—I knew I had to do science!” she says. Her family, especially her mother, were highly supportive of her academic choices, and always encouraged her to challenge herself. Her science teachers in high school served as her first role models. “These women were my initial contact with the sciences and their attitude propelled me forward, encouraging me in this domain which was widely perceived to be a male one at that time,” she says. After high school, Prudence went on to study biochemistry at the University of Zimbabwe where her main inspiration was Idah Sithole-Niang, who helped her become even more fascinated by the world of molecular biology and biochemistry. “Both her style of teaching and her research enthusiasm pushed me to dig deeper into the field of science, ask more questions, and begin to seriously consider a scientific career,” she says. Sithole-Niang observes of her former student that Prudence “does not scare easily” and always showed great initiative. “I had assigned her a project to isolate genomic DNA using kitchen ingredients, such as dish detergent, table salt, and alcohol, and gave 36 © 2009 American Association for the Advancement of Science. All Rights Reserved. In 2006, Prudence was awarded a UNESCOL’Oréal Fellowship, which enabled her to continue on as a Ph.D. student in molecular biology after she had transferred to the University of Nottingham in the United Kingdom. There she studied a special class of bacteria called Archaea, which are able to withstand extreme environments, such as excessive heat, pressure, and acidity. One group of these bacteria, known as halophiles, thrives in areas of high salt concentration. Specifically, Prudence sought to understand how proteins and DNA in the cell can interact at such high salt concentrations. After completing her Ph.D., Prudence has stayed on at the University of Nottingham as a postdoctoral research fellow in the School of Pharmacy, where she is applying her skills to cancer research in the Department of Structural Biology and Medicinal Chemistry. Mentoring a New Generation Prudence continues to collect awards and recognition for her work. She was selected to attend the prestigious Biovision World Life Sciences Forum in Lyon, France, in 2007, where she was able to meet with five Nobel Prize winners. She was also named in Marie Claire’s 2007 survey as one of the 25 most promising young women in the UK. Now, as part of the Sci-Tech girls project, a platform provided by L’Oréal, she counsels high school students about pursuing a career in science. “The capacity to be a mentor to these young girls, who are asking similar questions to the ones I had, is what I am most proud of to date,” she says humbly. Prudence plans to continue on in cancer research and says she would also like to increase her participation in speaking to the younger generation about scientific careers and “see more women take up their rightful place in scientific research.” According to Prudence, a scientific career is fascinating, rewarding, and extremely challenging, and “there is always that added excitement of working in an area ripe with the potential of making a discovery that may have a great impact on all humanity.” “The capacity to be a mentor to these young girls, who are asking similar questions to the ones I had, is what I am most proud of to date.” 37 Folk Medicine for the 21st Century G rowing up in Birzeit, Palestine, Mary George Kaileh thought she’d become a pharmacist, like her uncle. Entering Birzeit University, she planned to transfer eventually to a college offering a pharmacy degree—until her unexpected fascination with molecular biology surfaced. Hundreds of Helpful Plants With a Bachelor of Science degree in biology, Mary became a research assistant at her university, studying the effects of medicinal plants on bacteria. In Palestinian folk medicine, over 700 plant species are botanical pesticides or medicinal herbs. In 1999, professors from a consortium of Belgian universities visited her lab. Professor Guy Haegeman invited Mary to a three-month molecular biology training program at the University of Ghent, and later encouraged her to apply to their doctoral program. She received one of the consortium’s 10 annual graduate scholarships. For her Ph.D. in biochemistry, Mary researched potential anti-inflammatory and antitumor effects of local medicinal plants. “I looked for drugs to reduce the effects of a particular protein (NFκB), which leads to long-lasting inflammation if it is not properly regulated,” she explains. Attacking Inflammation but after her postdoc experience in the United States, she better understands her previous boss’s view. Having a Balanced Life Mary hadn’t expected to be one of only two women in her Ph.D. program. “In Palestine, 50 percent of university students are women. I was shocked that, around the world, the higher you go—at Ph.D. or professor levels—the lower the percentage of women scientists. Even in the US, with all the universities, you still don’t have many women in science,” she laments. But Mary is grateful that she’s able to continue her studies in the United States. “Palestine has limited graduate study. People often don’t have enough money to go abroad, like I did,” Mary observes. In Birzeit, Tamer Essawi urged her to pursue a Ph.D. Mary says that without the support of both her mentors, Essawi and Haegeman, “I wouldn’t be here now.” ‘She Will Crack the Problem’ “As a scientist, Mary brings rare intensity, determination and passion to her work,” says Ranjan Sen, chief of the NIA’s Laboratory of Cellular and Molecular Biology. “She exudes the attitude that she will crack the problem, no matter what it takes, and wills herself to reach beyond the easily accessible. Mary is the social life of our laboratory; her empathy toward colleagues is unmistakable.” After her postdoc ends, Mary has a clear goal: raising funds to start a research lab at Birzeit University, allowing local people to pursue graduate degrees. “From my scholarship, I was able to buy a little equipment. I hope I can do it—it’s so difficult to find funds, especially for a lab. Most funds for education in Palestine come from the European Union, so there is little money for costly research or expensive molecular biology equipment. With checkpoints and other obstacles, you can’t be sure you’ll get back to the lab to finish your work.” Despite the hurdles, “The women at our universities are looking to improve ourselves more and more,” she declares. Her research focused on Withania somnifera, a plant related to the deadly nightshade and used to treat wounds and reduce inflammation. “No one knew how it worked. I was the first person to study the molecular mechanism that controls the protein and the inflammation,” she says proudly. “But research is very competitive. Before I published my first paper, an article came out by an Indian researcher on the same subject. At first, it was a shock,” Mary confides. Fortunately, her research team, with more and broader data, was still able to publish their research in 2007. The research funded by her UNESCO-L’Oréal Fellowship in 2003 helped her complete her data analysis, Mary notes gratefully. “It’s a very nice program that recognizes women in science.” She wanted to travel to the United States for a postdoctoral fellowship. “I’d already tried science in Europe,” notes Mary, who is fluent in English, Palestine’s second language. As a visiting fellow at the National Institute on Aging (NIA) in Baltimore since March 2007, she studies the biology of certain immune system cells that are the basis for effective vaccination, hoping to discover new ways to treat disease. Mary finds that being a researcher in the United States is not like Europe, where she was encouraged to travel and to maintain a more balanced life. “Here, everything revolves around your work,” reflects Mary. “My boss in Ghent wanted us to work, but also to take vacations, to have a more open mind.” She couldn’t see the reason then, “ Without the support of my mentors, I wouldn’t be here now.” 38 © 2009 American Association for the Advancement of Science. All Rights Reserved. 39 Additional Online Resources www.aauw.org American Association of University Women www.awis.org Association for Women in Science www.braincake.org Brain Cake: The Girls, Math & Science Partnership www.engineergirl.org Engineer Girl - information on engineering for middle school girls www.engineeryourlife.org Engineer Your Life – a guide to engineering for girls in high school www.witec-eu.net European Association for Women in Science, Engineering and Technology www.expandingyourhorizons.org Expanding Your Horizons Program – conferences for young women www.girlsgotech.org Girls Go Tech - introducing young girls to the world of technology www.girlstart.org Girlstart - empowering girls in math, science, engineering, and technology www.ifuw.org International Federation of University Women www.iitap.iastate.edu/iwise International Women in Science and Engineering www.kineticcity.com Kinetic City - games and experiments that make science fun for all ages www.nasa.gov/audience/forstudents/index.html NASA - section of the NASA website especially for young scientists www.ncwit.org National Center for Women & Information Technology www.sbfonline.com/ Science Books & Films guide to science resources www.scienceareers.org/lorealwis Science/AAAS and L’Oreal booklets about Women in Science (download PDF version of this booklet here) www.scienceclubforgirls.org Science Club for Girls - increasing the self-confidence and science literacy of K–12th grade girls leo.aichi-u.ac.jp/~kunugi/sjws/e1.htm Society of Japanese Women Scientists 1998 Laureate for Asia-Pacific Myeong-Hee Yu, Republic of Korea www.twows.org Third World Organization for Women in Science www.webgrrls.com Webgrrls International www.womeninbio.org Women in Bio The L’Oréal-Unesco Awards honor women scientists from five continents. Each year, they are selected by an international jury www.wise.sunysb.edu Women in Science and Engineering presided by a Nobel Prize laureate. www.witi.com Women in Technology International The exceptional quality of their careers has made them quest.arc.nasa.gov/women/intro.html Women of the National Aeronautics and Space Administration (NASA) 2001 Laureate for Africa & Arab States Adeyinka Gladys Falusi, Nigeria role models for the next generation. Every year, L’Oréal and Unesco grant more than 160 fellowships to young women researchers in 50 countries. 2005 Laureate for North America Myriam Sarachik, USA Unesco and L’Oréal are convinced that science is Credits Cover: © iStockphoto.com/switas TOC: © iStockphoto.com/dstephens Page 3: © iStockphoto.com/hidesy Page 4: Top–© Micheline Pelletier Bottom–© Véronique/Gamma Page 5: © Olivier Douliery/Abaca Corporate Pages 6 and 7: Courtesy of Dr. Ines Atmosukarto Page 9: © iStockphoto.com/ArtisticCaptures Page 10: Top–© Christine Donnier-Valentin/Abaca Corporate Bottom–© iStockphoto.com/charliebishop Page 12: Left–© JF Deroubaix/Gamma Right–© iStockphoto.com/nileshb Page 13: Reema Fayez Tayyem Page 14: Right–© iStockphoto.com/coloroftime Page 15: © iStockphoto.com/Eraxion Page 16: © Olivier Douliery/Abaca Corporate Page 17: Top–© iStockphoto.com/geopaul Bottom–© Olivier Douliery/Abaca Corporate Science needs women Page 18: © Dieter Stumpf/Abacapress Page 19: Both–© Dieter Stumpf/Abacapress Page 20: © JF Deroubaix/Gamma Page 22: Left–© JF Deroubaix Right–Courtesy of S. Jenouvrier Page 23: Courtesy of S. Jenouvrier Page 24: © Micheline Pelletier Page 25: © Micheline Pelletier Page 26: Courtesy of Gisella Cruz García Page 27: www.jeroenvanloon.nl Page 28: Fernando Milesi, edited by Cyril Bruneau Page 29: © JF Deroubaix/Gamma Page 30: Left–photo illustration-Amy Hardcastle; © iStockphoto.com/fotoIE Page 32: Left–© Micheline Pelletier Page 33: © Micheline Pelletier Page 35: © iStockphoto.com/johnwoodcock Page 36 and 37: Photos: Laura Holt 40 © 2009 American Association for the Advancement of Science. All Rights Reserved. the source of progress for society and that women have an essential role to play in that progress. www.forwomeninscience.com 2006 Laureate for Latin America Esther Orozco, Mexico 2008 2006 Laureate for Europe Ada Yonath, Israel – © Corbis. Science needs women www.forwomeninscience.com 42 © 2009 American Association for the Advancement of Science. All Rights Reserved.
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