vi
TABLE OF CONTENTS
CHAPTER
TITLE
PAGE
DECLARATION
ii
ACKNOWLEDGEMENTS
iii
ABSTRACT (ENGLISH)
iv
ABSTRAK (BM)
v
TABLE OF CONTENTS
vi
LIST OF TABLES
viii
LIST OF FIGURES
ix
LIST OF SYMBOLS
x
1. INTRODUCTION
1.1
General overview of a syringe pump
1
1.2
Syringe pump operating principle
3
1.3
Literature review
4
1.4
Volume dispense syringe pump
8
1.4.1 Flow rate and volume rate
8
2. RESEARCH METHODOLOGY
2.1
Project objective
10
2.2
Project Controller description
11
2.2.1 Controller assembly language
13
2.2.2 Program operation
13
2.3
Syringe size
15
2.4
Pump assembly
17
2.4.1
18
Stepper motor
vii
2.4.2
Actuator assembly (ball screw)
2.4.3
LVDT (Linear Variable differential
transformer
2.5
19
22
Volume rate calibration
23
2.5.1
25
Experiments
3. RESULTS
3.1
Results of data and figures plotted
26
3.1.1 Experiment 1
26
3.1.2 Experiment 2
31
3.1.2 Experiment 3
36
4.1
Analysis of linear models
38
4.2
Experiment 1 discussion
39
4.3
Experiment 2 discussion
43
4.4
Experiment 3 discussion
44
5.1
Pump performance
46
4. DISSCUSSION
5. CONCLUSION
REFERENCES
49
APPENDICE A
50
viii
LIST OF TABLES
TABLE NO.
TITLE
PAGE
3.1
Data settings of time and position for 0.4mL volume
26
3.2
Data settings of time and position for 0.1mL volume
29
ix
LIST OF FIGURES
FIGURE NO.
TITLE
PAGE
1.1
Various types of infusion pump in the market
3
1.2
Syringe sizes with different mL range
4
1.3
Cross sectional of a syringe pump architecture
9
2.1
PIC16F Controller schematic architecture
11
2.2
Microcontroller board with switches and Led
14
2.3
LCD Display
15
2.4
Syringe size of 6mL with divisions of 0.4mL
16
2.5
Syringe size of 3mL with every 2 division of 0.2mL
17
2.6
TECO bipolar stepper motor
18
2.7
Ball screw actuator and lead screw actuator
20
2.8
Potentiometric linear transducer
22
2.9
Complete volume dispense syringe pump with controller 23
3.1
Time measure against 0.4mL volume dispensed
27
3.2
Position measure against 0.4mL volume dispensed
28
3.3
Time measured against 1mL volume dispensed
29
3.4
Position measure against 1mL volume dispensed
30
3.5
Time set against time measure for 0.4mL volume
31
3.6
Position measured against position set for every 0.4mL 32
3.7
Time set against time measured for 1mL volume
3.8
Position measured against position set for 1mL volume 34
3.9
Time taken against every volume of 0.2mL dispensed
3.10
Position measured with volume dispensed every 0.2mL 37
33
36
x
LIST OF SYMBOLS
mL
-
milliliter
cc
-
cubic centimeter
F
-
Force
x°
-
Degree angle
t
-
time
mL/hr
milliliter per hour