Ordering Information
Immunoassay
Stabilizers
Conjugate
Stabilizers
TMB Substrates
HAMA Blocker
Product Code
Product
Available Sizes
SC01
StabilCoat
Immunoassay Stabilizer
50 mL, 1L & 2L
SC05
5X StabilCoat®
Immunoassay Stabilizer
50 mL, 1L & 2L
SG01
StabilGuard
Immunoassay Stabilizer
50 mL & 1L
ST01
StabilBlock®
Immunoassay Stabilizer
50 mL & 1L
SZ02
StabilZyme®
HRP Stabilizer
50 mL, 1L & 2L
SZ03
StabilZyme®
SELECT Stabilizer
50 mL, 1L & 2L
SZ04
StabilZyme®
NOBLE Stabilizer
50 mL, 1L & 2L
SZPF
StabilZyme®
Protein-Free Stabilizer
50 mL, 1L & 2L
SA01
StabilZyme®
AP Stabilizer
50 mL, 1L & 2L
SAPF
StabilZyme®
Protein-Free AP Stabilizer
50 mL, 1L & 2L
TMBS
TMB Super Sensitive One Component
HRP Microwell Substrate
100 mL, 1000 mL,
Custom Sizes
TMBW
TMB One Component
HRP Microwell Substrate
100 mL, 1000 mL,
Custom Sizes
TMBC
TMB Conductivity One Component
HRP Microwell Substrate
100 mL, 1000 mL,
Custom Sizes
TMSK
TMB Slow Kinetic One Component
HRP Microwell Substrate
100 mL, 1000 mL,
Custom Sizes
TTMB
TMB Super Slow One Component
HRP Microwell Substrate
100 mL, 1000 mL,
Custom Sizes
TMDS
TMB Double Slow One Component
HRP Microwell Substrate
100 mL, 1000 mL,
Custom Sizes
TMBX
TMB Extended Range
HRP Microwell Substrate
100 mL, 1000 mL,
Custom Sizes
SM01
Assay Diluent
(Protein-Free)
50 mL & 1L
®
®
FOR ADDITIONAL PRODUCT OR TECHNICAL INFORMATION,
PLEASE CONTACT US AT 952-500-7200 OR [email protected]
FOR TECHNICAL ASSISTANCE: [email protected]
Surmodics IVD, Inc.
9924 West 74th Street
Eden Prairie, MN 55344 USA
Toll Free 1-800-755-7793
Phone 952-500-7200
Fax 952-500-7201
www.surmodics.com/ivd
shop.surmodics.com/ivd
Surmodics, StabilZyme and StabilZyme SELECT are trademarks of Surmodics, Inc. and/or its affiliates.
Surmodics, StabilBlock, StabilCoat and StabilGuard are trademarks of Surmodics, Inc. and/or its affiliates.
© 2016 Surmodics, Inc.
All rights reserved. COAT 0716.04
SURMODICS IN VITRO DIAGNOSTIC PRODUCTS
IMMUNOASSAY
STABILIZERS
AMP UP THE SIGNAL.
DIAL DOWN THE NOISE.
SURMODICS IMMUNOASSAY STABILIZERS
Unmatched stabilization of dried proteins and blocking
efficacy in a one-step process
SIGNAL-TO-NOISE RATIOS
Boosting sensitivity. Surmodics Immunoassay Stabilizers
provide a choice of blocking mechanisms to achieve optimal
signal-to-noise ratios for each assay.
Surmodics immunoassay reagents preserve the conformation and activity of dried proteins coated on a wide range
of surfaces, keeping antibodies and antigens at peak performance for long durations. At the same time, the blocking
mechanisms in these reagents reduce non-specific binding of interfering proteins to maximize assay sensitivity.
Low standards were run on a commercial PAPP-A sandwich assay using
plates coated with StabilBlock®, StabilCoat®, StabilGuard® Immunoassay
stabilizers and a competitive commercial blocker. The signal-to-noise ratios
were quantified.
Our immunoassay stabilizers are the industry gold standard for stability and blocking efficacy. The result is
immediate improvement of assay performance in a one-step process for streamlined manufacturing.
StabilBlock®: enhanced blocking capability
DRIED PROTEIN STABILITY
Assay developers need numerous blocking mechanisms while selecting the antibody titration during assay
optimization. Surmodics Immunoassay Stabilizers provide alternative blocking mechanisms to achieve the best
signal-to-noise ratios for each assay.
With the introduction of StabilBlock®, Surmodics now offers the best available reagent for reducing non-specific
binding to boost immunoassay signal-to-noise ratios.
Prolonging shelf life. Accelerated stability projections
demonstrate at least 85% retained activity for greater than
2 years using Surmodics Immunoassay Stabilizers.
The accelerated stability tests used a rabbit polyclonal IgG ELISA assay to
assess each stabilizer. 77 days of accelerated stability testing is equivalent
to 2+ years of real-time stability.
NON-SPECIFIC BINDING
LONGER
STABILITY
INCREASED
SENSITIVITY
NEGLIGIBLE
BACKGROUNDS
• Extended shelf life
of dried proteins
on various
surfaces, including
polystyrene plates,
latex beads,
magnetics particles
and nitrocellulose
membranes
• Increased signalto-noise ratios
across the assay
range
• Elimination of nonspecific binding
from the sample
matrix and other
assay components
• Multiple
formulations to
optimize lower
detection limits
EASE OF
MANUFACTURE
Lowering non-specific binding. StabilBlock® minimizes
non-specific binding from the sample matrix and downstream
assay components to enable lower detection limits.
• One-step blocking
and stabilization
process for shorter
cycle times
A serum assay was constructed to demonstrate lower non-specific binding
from the sample matrix. Mouse IgG was passively absorbed onto a plate and
blocked. Human serum was incubated, washed and detected using an antihuman IgG (HRP) conjugate. Passive absorption of serum on the plate was
quantified.
• ISO 13485/9001
facility for lot-to-lot
consistency
Specifications and Properties
StabilCoat®
Immunoassay Stabilizer
Application
StabilBlock Immunoassay Stabilizer gives assay
developers the best possible tool to lower nonspecific binding and maximize the signal-to-noise
ratios of assays.
®
StabilCoat and StabilGuard (protein free)
Immunoassay Stabilizers increase signal-tonoise ratios of assays through effective blocking
of the plate while maximizing the binding
capacity of the antigen/antibody epitopes.
®
®
5X StabilCoat®
Immunoassay Stabilizer
StabilGuard®
Immunoassay Stabilizer
StabilBlock®
Immunoassay Stabilizer
Dried protein stability & blocking of the solid support for immunoassays
Protein Content
Bovine
Bovine
Synthetic
Proprietary
Product Buffer
PBS
PBS
PBS
MOPS
pH
Shelf Life
Preservative
7.0-7.4
7.0-7.4
6.6-7.2
6.8-7.2
36 months
24 months
36 months
36 months
Filtered through a 0.01 micron filter
Preservative added &
filtered through a 0.01
micron filter
SURMODICS IMMUNOASSAY STABILIZERS
Unmatched stabilization of dried proteins and blocking
efficacy in a one-step process
SIGNAL-TO-NOISE RATIOS
Boosting sensitivity. Surmodics Immunoassay Stabilizers
provide a choice of blocking mechanisms to achieve optimal
signal-to-noise ratios for each assay.
Surmodics immunoassay reagents preserve the conformation and activity of dried proteins coated on a wide range
of surfaces, keeping antibodies and antigens at peak performance for long durations. At the same time, the blocking
mechanisms in these reagents reduce non-specific binding of interfering proteins to maximize assay sensitivity.
Low standards were run on a commercial PAPP-A sandwich assay using
plates coated with StabilBlock®, StabilCoat®, StabilGuard® Immunoassay
stabilizers and a competitive commercial blocker. The signal-to-noise ratios
were quantified.
Our immunoassay stabilizers are the industry gold standard for stability and blocking efficacy. The result is
immediate improvement of assay performance in a one-step process for streamlined manufacturing.
StabilBlock®: enhanced blocking capability
DRIED PROTEIN STABILITY
Assay developers need numerous blocking mechanisms while selecting the antibody titration during assay
optimization. Surmodics Immunoassay Stabilizers provide alternative blocking mechanisms to achieve the best
signal-to-noise ratios for each assay.
With the introduction of StabilBlock®, Surmodics now offers the best available reagent for reducing non-specific
binding to boost immunoassay signal-to-noise ratios.
Prolonging shelf life. Accelerated stability projections
demonstrate at least 85% retained activity for greater than
2 years using Surmodics Immunoassay Stabilizers.
The accelerated stability tests used a rabbit polyclonal IgG ELISA assay to
assess each stabilizer. 77 days of accelerated stability testing is equivalent
to 2+ years of real-time stability.
NON-SPECIFIC BINDING
LONGER
STABILITY
INCREASED
SENSITIVITY
NEGLIGIBLE
BACKGROUNDS
• Extended shelf life
of dried proteins
on various
surfaces, including
polystyrene plates,
latex beads,
magnetics particles
and nitrocellulose
membranes
• Increased signalto-noise ratios
across the assay
range
• Elimination of nonspecific binding
from the sample
matrix and other
assay components
• Multiple
formulations to
optimize lower
detection limits
EASE OF
MANUFACTURE
Lowering non-specific binding. StabilBlock® minimizes
non-specific binding from the sample matrix and downstream
assay components to enable lower detection limits.
• One-step blocking
and stabilization
process for shorter
cycle times
A serum assay was constructed to demonstrate lower non-specific binding
from the sample matrix. Mouse IgG was passively absorbed onto a plate and
blocked. Human serum was incubated, washed and detected using an antihuman IgG (HRP) conjugate. Passive absorption of serum on the plate was
quantified.
• ISO 13485/9001
facility for lot-to-lot
consistency
Specifications and Properties
StabilCoat®
Immunoassay Stabilizer
Application
StabilBlock Immunoassay Stabilizer gives assay
developers the best possible tool to lower nonspecific binding and maximize the signal-to-noise
ratios of assays.
®
StabilCoat and StabilGuard (protein free)
Immunoassay Stabilizers increase signal-tonoise ratios of assays through effective blocking
of the plate while maximizing the binding
capacity of the antigen/antibody epitopes.
®
®
5X StabilCoat®
Immunoassay Stabilizer
StabilGuard®
Immunoassay Stabilizer
StabilBlock®
Immunoassay Stabilizer
Dried protein stability & blocking of the solid support for immunoassays
Protein Content
Bovine
Bovine
Synthetic
Proprietary
Product Buffer
PBS
PBS
PBS
MOPS
pH
Shelf Life
Preservative
7.0-7.4
7.0-7.4
6.6-7.2
6.8-7.2
36 months
24 months
36 months
36 months
Filtered through a 0.01 micron filter
Preservative added &
filtered through a 0.01
micron filter
Ordering Information
Immunoassay
Stabilizers
Conjugate
Stabilizers
TMB Substrates
HAMA Blocker
Product Code
Product
Available Sizes
SC01
StabilCoat
Immunoassay Stabilizer
50 mL, 1L & 2L
SC05
5X StabilCoat®
Immunoassay Stabilizer
50 mL, 1L & 2L
SG01
StabilGuard
Immunoassay Stabilizer
50 mL & 1L
ST01
StabilBlock®
Immunoassay Stabilizer
50 mL & 1L
SZ02
StabilZyme®
HRP Stabilizer
50 mL, 1L & 2L
SZ03
StabilZyme®
SELECT Stabilizer
50 mL, 1L & 2L
SZ04
StabilZyme®
NOBLE Stabilizer
50 mL, 1L & 2L
SZPF
StabilZyme®
Protein-Free Stabilizer
50 mL, 1L & 2L
SA01
StabilZyme®
AP Stabilizer
50 mL, 1L & 2L
SAPF
StabilZyme®
Protein-Free AP Stabilizer
50 mL, 1L & 2L
TMBS
TMB Super Sensitive One Component
HRP Microwell Substrate
100 mL, 1000 mL,
Custom Sizes
TMBW
TMB One Component
HRP Microwell Substrate
100 mL, 1000 mL,
Custom Sizes
TMBC
TMB Conductivity One Component
HRP Microwell Substrate
100 mL, 1000 mL,
Custom Sizes
TMSK
TMB Slow Kinetic One Component
HRP Microwell Substrate
100 mL, 1000 mL,
Custom Sizes
TTMB
TMB Super Slow One Component
HRP Microwell Substrate
100 mL, 1000 mL,
Custom Sizes
TMDS
TMB Double Slow One Component
HRP Microwell Substrate
100 mL, 1000 mL,
Custom Sizes
TMBX
TMB Extended Range
HRP Microwell Substrate
100 mL, 1000 mL,
Custom Sizes
SM01
Assay Diluent
(Protein-Free)
50 mL & 1L
®
®
FOR ADDITIONAL PRODUCT OR TECHNICAL INFORMATION,
PLEASE CONTACT US AT 952-500-7200 OR [email protected]
FOR TECHNICAL ASSISTANCE: [email protected]
Surmodics IVD, Inc.
9924 West 74th Street
Eden Prairie, MN 55344 USA
Toll Free 1-800-755-7793
Phone 952-500-7200
Fax 952-500-7201
www.surmodics.com/ivd
shop.surmodics.com/ivd
Surmodics, StabilZyme and StabilZyme SELECT are trademarks of Surmodics, Inc. and/or its affiliates.
Surmodics, StabilBlock, StabilCoat and StabilGuard are trademarks of Surmodics, Inc. and/or its affiliates.
© 2016 Surmodics, Inc.
All rights reserved. COAT 0716.04
SURMODICS IN VITRO DIAGNOSTIC PRODUCTS
IMMUNOASSAY
STABILIZERS
AMP UP THE SIGNAL.
DIAL DOWN THE NOISE.