Keystone Symposia is pleased to present
Nuclear Receptors and Friends:
Roles in Energy Homeostasis
and Metabolic Dysfunction

Scientific Organizers: Antonio J. Vidal-Puig, Antonio Moschetta and Anastasia Kralli
April 3–8, 2013 | Alpbach Congress Centrum | Alpbach, Austria
T
his meeting brings fundamental cellular and
physiological principles involving nuclear receptors and
other transcription factors to the boundaries between
physiology and disease-oriented research. As evidenced by
the session titles, the organizers have developed a program
that covers the involvement of nuclear receptors (NR) and
other transcription factors (TFs) regulating energy balance
(food intake, energy expenditure and fat deposition), and
their pathophysiological dysregulation leading to obesityassociated cardio-metabolic complications. The program
has been configured to bring together diverse, sometimes
conflicting ideas, and novel approaches to investigate the
involvement of NR and TFs that may help to elucidate them.
A primary goal is to gather junior and senior investigators
who study transcriptional mechanisms controlling different
aspects of energy homeostasis and metabolic adaptation,
and thereby stimulate new ideas as to how transcriptional
networks could be targeted therapeutically in the context
of metabolic disease. Taken together, the program design
will provide an interdisciplinary integration of multiple
organs and systems regulating energy homeostasis. Thus,
this meeting is highly likely to attract a wide variety of
investigators, many of whom might not otherwise interact.
Plenary Session Topics:
> Nuclear Receptors and Metabolism: Liver and Gut Pathways
> Nuclear Receptors and Control of Food Intake
> Nuclear Receptors and Energy Expenditure Pathways
> Adipogenesis and Energy Storage
> Lipid Metabolic Sensors
> Immune System and Metabolism
> Skeletal Muscle, Exercise and Diet
> Circadian Clock and Metabolism
Abstract & Scholarship Deadline: December 4, 2012
Late-Breaking Abstract Deadline: January 4, 2013
Early Registration Deadline: January 31, 2013
1.970.262.1230 | 1.800.253.0685 (US & Canada)
Keystone Symposia on Molecular and Cellular Biology is a nonprofit organization
headquartered in Colorado, USA directed and supported by the scientific community.
Note: Scholarships are available to students and postdoctoral fellows and require
a brief application and submission of an abstract. Short talk speakers will also be
selected from abstracts. Early registration saves US$150 on later fee. Information
shown is subject to possible change.
www.keystonesymposia.org/13D3
Keystone Symposia on Molecular and Cellular Biology is a nonprofit organization headquartered in Colorado, USA directed and supported by the scientific community.
KEYSTONE SYMPOSIA
on Molecular and Cellular Biology
Nuclear Receptors and Friends: Roles in Energy Homeostasis and Metabolic Dysfunction (D3)
April 3-8, 2013 • Alpbach Congress Centrum • Alpbach, Austria
Scientific Organizers: Antonio J. Vidal-Puig, Antonio Moschetta and Anastasia Kralli
Supported by the Directors' Fund
Abstract & Scholarship Deadline: December 4, 2012 / Late-Breaking Abstract Deadline: January 4, 2013 / Early Registration Deadline: January 31, 2013
WEDNESDAY, APRIL 3
Arrival and Registration
THURSDAY, APRIL 4
Welcome and Keynote Address
Antonio J. Vidal-Puig, University of Cambridge, UK
Welcoming Remarks
*Antonio Moschetta, Clinica Medica Frugoni, University of Bari, Italy
Helen H. Hobbs, University of Texas Southwestern Medical Center,
USA
ABCG5/ABCG8: A Sterol Selectivity Filter for Cholesterol
Homeostasis
Nuclear Receptors and Metabolism: Liver and Gut Pathways
*Michael Trauner, Medical University of Vienna, Austria
David D. Moore, Baylor College of Medicine, USA
Nutrient Sensing Nuclear Receptors REgulat Autophagy
David Shapiro, Intercept Pharmaceuticals, Inc., USA
FXR Agonism – From Theory to Practice
Antonio Moschetta, Clinica Medica Frugoni, University of Bari, Italy
FXR in the Gut-Liver Axis
Michela Plateroti, Université Claude Bernard Lyon 1, France
Thyroid Hormone Receptor and Intestinal Epithelium Stemness
Nuclear Receptors and Control of Food Intake
*Beatrice Desvergne, University of Lausanne, Switzerland
Joel K. Elmquist, University of Texas Southwestern Medical Center,
USA
SF-1: A Molecular Link between Coordinated Energy Balance and
Mood
Miguel López, Universidad de Santiago de Compostela, Spain
Central Actions of Estrogens on Energy Balance
Tony K.T. Lam, Toronto General Research Institute, Canada
CNS Action of Insulin and Glucagon
Brian Finan, Novo Nordisk, USA
Short Talk: Targeted Nuclear Hormone Delivery Using Natural
Peptides
Poster Session 1
FRIDAY, APRIL 5
Nuclear Receptors and Energy Expenditure Pathways
*Daniel P. Kelly, Sanford Burnham Prebys Medical Discovery
Institute, USA
Anastasia Kralli, Johns Hopkins Medical School, USA
Estrogen-Related Receptors (ERRs) and ERR Coregulators:
Pathways Regulating Energy Expenditure in Brown Adipose Tissue
Antonio J. Vidal-Puig, University of Cambridge, UK
Brown Fat Activity Modulators
Krishna Chatterjee, University of Cambridge, UK
Nuclear Receptors and Metabolic Dysfunction: Insights from Human
Genetics
Beatrice Desvergne, University of Lausanne, Switzerland
Too Much or Too Little Fat: Same Metabolic Consequences, Same
Mechanisms?
Alessandra Ferrari, Università degli Studi di Milano, Italy
Short Talk: Key Role of Class I Histone Deacetylases in Energy
Metabolism via Regulation of Pgc-1alpha and PPARgamma
Juliane G. Bogner-Strauss, Graz University of Technology, Austria
Short Talk: N-Acetyltransferase 8-Like: New Implications in Brown
Adipocyte Metabolism through PPARalpha Signaling
Workshop and Round-Table Discussion: Targeting NRs for the
Treatment of Metabolic Disease
*Peter Tontonoz, HHMI/University of California, Los Angeles, USA
C. Daniel De Magalhaes Filho, The Salk Institute for Biological
Studies, USA
The Effects of Overactivating a Fat Burning Pathway Upon Systemic
Aging and Age-Related Cardiac Health
David P. Marciano, Stanford University, USA
Modulating the PPARgamma Paradigm: Structural Insights into a
Novel Class of Functional Selective Ligands
Knut R. Steffensen, Karolinska Institute, Sweden
The Anti-inflammatory Roles of the Liver X Receptors in Colon
Constance Maria Voss, University of Vienna, Austria
Identification and Investigation of Novel LXR Modulators
Round-Table Discussion
*David J. Mangelsdorf, University of Texas Southwestern Medical
Center, USA
Krishna Chatterjee, University of Cambridge, UK
David Shapiro, Intercept Pharmaceuticals, Inc., USA
Adipogenesis and Energy Storage
*Karen Reue, University of California, Los Angeles, USA
Evan D. Rosen, Beth Israel Deaconess Medical Center, Harvard
University, USA
Epigenomic Approaches to Target Identification in Adipose Biology
Juro Sakai, University of Tokyo, Japan
Epigenomic Regulation of Energy Metabolism in Brown Adipocytes
Lluis Fajas, Université de Lausanne, Switzerland
Cell Cycle Regulators Control Energy Homeostasis
Amit R. Majithia, Massachusetts General Hospital, USA
Short Talk: High Throughput Functional Analysis of Coding Variants
Identified in Population Scale Genome Sequencing: A Paradigm for
Mapping Genes Underlying Human Metabolic Diseases
Ralf Kittler, University of Texas Southwestern Medical Center, USA
Short Talk: Pyruvate Dehydrogenase Kinase 4 Is a Key Metabolic
Regulator of PPARgamma-Mediated Cell Cycle Arrest
* Session Chair † Invited but not yet accepted Program current as of June 18, 2017. Program subject to change. Meal formats are based on meeting venue.
For the most up-to-date details, visit www.keystonesymposia.org/13D3.
KEYSTONE SYMPOSIA
on Molecular and Cellular Biology
Nuclear Receptors and Friends: Roles in Energy Homeostasis and Metabolic Dysfunction (D3)
April 3-8, 2013 • Alpbach Congress Centrum • Alpbach, Austria
Scientific Organizers: Antonio J. Vidal-Puig, Antonio Moschetta and Anastasia Kralli
Supported by the Directors' Fund
Abstract & Scholarship Deadline: December 4, 2012 / Late-Breaking Abstract Deadline: January 4, 2013 / Early Registration Deadline: January 31, 2013
Poster Session 2
SATURDAY, APRIL 6
Nutrient Challenges and Lipid Homeostasis
*Helen H. Hobbs, University of Texas Southwestern Medical Center,
USA
David J. Mangelsdorf, University of Texas Southwestern Medical
Center, USA
A Survivor’s Guide to the Hunger Games: FGF21
Peter Tontonoz, HHMI/University of California, Los Angeles, USA
Nuclear Receptor Regulation of Lipid Metabolism and Inflammation
Ronald M. Evans, Howard Hughes Medical Institute, Salk Institute,
USA
Catching Fire with FGF1: The Hunger Games Sequel
Jaemyoung Suh, KAIST - Korea Advanced Institute of Science &
Technology, South Korea
Catching Fire with FGF1: The Hunger Games Sequel
Karen Reue, University of California, Los Angeles, USA
Reflections on Lipin Proteins, Lipid Storage, and Lipid Intermediates
Federica Gilardi, University of Lausanne, Switzerland
Short Talk: Dynamics of SREBP1 DNA Binding in Mouse Liver
Pedro F. Marrero, University of Barcelona, Spain
Short Talk: FSP27 Expression Regulates Liver PPARalpha Signaling
Activity
Editors' Round-Table
Randy S. Levinson, Nature Publishing Group, USA
Effie Tzameli, Cell Press, USA
Esther Schnapp, EMBO, Germany
Workshop 2
*George E.O. Muscat, University of Queensland, Australia
Elnaz Karimian Azari, ETH-IFNH, Switzerland
Possible Role of Intestinal Fatty Acid Oxidation (FAO) in the
Peroxisome Proliferator Receptor-alpha (PPAR-alpha) Agonist
Wy-14643-Induced Hypophagia
Pooja Jha, École Polytechnique Fédérale de Lausanne, Switzerland
Adipose Triglyceride Lipase Critically Determines Hepatic
Inflammation and Steatohepatitis via PPARalpha Signaling
Michele Vacca, Consorzio Mario Negri Sud, Italy
Neuron-Derived Orphan Receptor 1 Acts as a Switch that Allows
Proliferation in Quiescent Hepatocytes
Carmine Settembre, Telethon Institute of Genetics and Medicine
(TIGEM), Italy
TFEB Controls Cellular Lipid Metabolism through a
Starvation-Induced Autoregulatory Loop
Kai Ge, NIDDK, National Institutes of Health, USA
Epigenetic Regulation of Adipogenesis by Histone Methylation
Andrea L. Hevener, University of California, Los Angeles, USA
Skeletal Muscle-Specific ERalpha Deficiency Impairs Mitochondrial
Quality Control and Promotes Features of the Metabolic Syndrome
Lily C. Chao, Children's Hospital Los Angeles, USA
NR4A1 Regulation of Fbp2 Promotes Muscle Growth
Immune System and Metabolism
*Thomas P. Burris, St. Louis University School of Medicine, USA
Mercedes Ricote, Centro Nacional de Investigaciones
Cardiovasculares, Spain
Emerging Roles of RXRs in Macrophage Biology
Ajay Chawla, University of California, San Francisco, USA
Type 2 Immunity at the Crossroads of Metabolism and Regeneration
Inez Rogatsky, Weill Medical College of Cornell University, USA
Anti-Inflammatory Actions of Glucocorticoids: New Players and
Mechanisms
Eckardt Treuter, Karolinska Institutet, Sweden
Short Talk: Dysregulation of a GPS2/SMRT Corepressor Pathway
Coincides with Adipocyte Inflammation in Human Obesity
Poster Session 3
SUNDAY, APRIL 7
Skeletal Muscle, Exercise and Diet
*Andrea L. Hevener, University of California, Los Angeles, USA
Daniel P. Kelly, Sanford Burnham Prebys Medical Discovery Institute,
USA
Nuclear Receptor-miRNA Regulatory Networks
Juleen R. Zierath, Karolinska Institutet, Sweden
Epigenetic Regulation in Response to Exercise: Impact on Diabetes
and Obesity
Vincent Giguère, McGill University, Canada
mTOR: A New Friend of the Estrogen Related Receptor alpha
Carl S. Thummel, University of Utah School of Medicine, USA
Regulation of Carbohydrate Metabolism by ERR and HNF4 in
Drosophila
George E.O. Muscat, University of Queensland, Australia
Short Talk: Transgenic Nor-1/NR4A3 Expression Decreases
Adiposity: Resistance to (High Fat) Diet Induced Obesity in a
Background of Insulin Resistance
Noriaki Shimizu, University of Tokyo, Japan
Short Talk: Physiological Regulation of Skeletal Muscle Mass via
Glucocorticoid Receptor
Circadian Clock and Metabolism
*Vincent Giguère, McGill University, Canada
Paolo Sassone-Corsi, University of California, Irvine, USA
Metabolism Control of the Circadian Clock
Thomas P. Burris, St. Louis University School of Medicine, USA
ROR and REV-ERB Regulation of Immune Function and Metabolism
Kenneth A. Dyar, Venetian Institute of Molecular Medicine, Italy
Short Talk: The Skeletal Muscle Circadian Clock Controls Insulin
Sensitivity and Metabolic Flexibility
Erin Stashi, Baylor College of Medicine, USA
Short Talk: SRC-2 Is Essential for Orchestrating Circadian Rhythm
and Metabolism
* Session Chair † Invited but not yet accepted Program current as of June 18, 2017. Program subject to change. Meal formats are based on meeting venue.
For the most up-to-date details, visit www.keystonesymposia.org/13D3.
KEYSTONE SYMPOSIA
on Molecular and Cellular Biology
Nuclear Receptors and Friends: Roles in Energy Homeostasis and Metabolic Dysfunction (D3)
April 3-8, 2013 • Alpbach Congress Centrum • Alpbach, Austria
Scientific Organizers: Antonio J. Vidal-Puig, Antonio Moschetta and Anastasia Kralli
Supported by the Directors' Fund
Abstract & Scholarship Deadline: December 4, 2012 / Late-Breaking Abstract Deadline: January 4, 2013 / Early Registration Deadline: January 31, 2013
Closing Remarks
Anastasia Kralli, Johns Hopkins Medical School, USA
MONDAY, APRIL 8
Departure
* Session Chair † Invited but not yet accepted Program current as of June 18, 2017. Program subject to change. Meal formats are based on meeting venue.
For the most up-to-date details, visit www.keystonesymposia.org/13D3.