DOI: http://dx.doi.org/10.14236/ewic/eva2014.37 6HHLQJStreptococcus pneumoniae D&RPPRQ.LOOHU%DFWHULD 5LNNH6FKPLGW.M UJDDUG $DUKXV8QLYHUVLW\ $DUKXV,QVWLWXWHRI$GYDQFHG6WXGLHV ,QWHUGLVFLSOLQDU\1DQRVFLHQFH&HQWHU +¡HJK*XOGEHUJV*DGH%'.$DUKXV& 'HQPDUN [email protected] (EEH6ORWK$QGHUVHQ $DUKXV8QLYHUVLW\ ,QWHUGLVFLSOLQDU\1DQRVFLHQFH&HQWHU *XVWDY:LHGV9HM '.$DUKXV& 'HQPDUN [email protected] Look around you. The diversity and complexity of life on earth is overwhelming and data continues to grow. In our desire to understand and explain everything scientifically from molecular evolution to supernovas we depend on visual representations. This paper investigates visual representations of the bacteria Streptococcus pneumoniae by use of ink, watercolours and computer graphics. We propose a novel artistic visual rendering of Streptococcus pneumoniae and ask what the value of these kind of representations are compared to traditional scientific data. We ask if drawings and computer-assisted representations can add to our scientific knowledge about this dangerous bacterium. Is there still a role for the scientific illustrator in the scientific process and synthesis of scientific knowledge? Bacteria. Streptococcus pneumonia. Visual representation. Molecular landscape. Data visualisation. Drawing, watercolour. Computer graphics. 2009) and ask what the value of these kinds of representations are. Is there still a role for the scientific illustrator? 1. INTRODUCTION 5HSUHVHQWLQJ GDWD LV QRW D QHXWUDO DQG XQELDVHG SUDFWLFH 7KH YLVXDO UHVXOW LV XVXDOO\ D KLJKO\ VXEMHFWLYH FRPSRVLWLRQ :H XVH GUDZLQJV DQG UHILQHGVNHWFKHVDVDQDFWLYHWRROLQWKHSURFHVVRI XQGHUVWDQGLQJ DQG VLPSOLI\ WKH QDWXUDO HOHPHQWV RXWOLQLQJ RXU ZRUOG 7KH YLVXDO RIWHQ DUWLVWLF DQG DHVWKHWLF DSSURDFK LV HVVHQWLDO WR D FUHDWLYH DQG DGYDQFHG SURFHVV SURGXFLQJ JURXQGEUHDNLQJ VFLHQWLILFUHVXOWV +RZZHWKLQNDERXWDQGSXEOLVKELRORJLFDOGDWDKDV FKDQJHG SURIRXQGO\ GXULQJ WKH ODVW FRXSOH RI FHQWXULHV )RU H[DPSOH FRQVLGHU WKH Origin of SpeciesE\&KDUOHV'DUZLQKDYLQJRQO\RQHILJXUH RIDSK\ORJHQHWLFWUHHZKHQSXEOLVKHGLQDQG -DPHV':DWVRQDQG)UDQFLV&ULFNV¶DUWLFOHRIWKH VWUXFWXUH RI '1$ KDYLQJ RQO\ RQH VLPSOH KDQG GUDZLQJRIWKHGRXEOHKHOL[LQ%\FRPSDULVRQ WKH +XPDQ *HQRPH SXEOLVKHG LQ Nature LQ KDGILJXUHVDFFRPSDQ\LQJWKHDUWLFOH/DQGHUet al. 9LVXDO UHSUHVHQWDWLRQV DUH EHFRPLQJ LQFUHDVLQJO\LPSRUWDQWWRRXUVFLHQWLILFLQWHUSUHWDWLRQ RIGDWD We propose a novel artistic visual rendering of 6WUHSWRFRFFXV SQHXPRQLDH (Figure 1) inspired by previous work done by David Goodsell (Goodsell Figure 1: Electron microscopy image of the Streptococcus pneumoniae capsule, cell wall and plasma membrane (Reproduced with permission from Professor Uffe B. Skov Sørensen) 2. VISUAL CHALLENGES )RU PROHFXODU DQG QDQRVFDOH GDWD ZH DUH IDFHG ZLWK D ZLGH UDQJH RI GHFLVLRQV DQG FKDOOHQJHV ZKHUH OHYHO RI DFFXUDF\ VFDOH VKDSH FRORXU GHVLJQG\QDPLFVDQGFRPSUHKHQVLELOLW\QHHGWREH ZHLJKHG 7KHVH GHFLVLRQV RI LQIRUPDWLRQ DQG GDWD Seeing VWUHSWRFRFFXVSQHXPRQLDHa common killer bacteria Rikke Schmidt Kjærgaard & Ebbe Sloth Andersen RI DOO SQHXPRFRFFDO GLVHDVHV JOREDOO\ ,Q JOREDOO\ SQHXPRFRFFDO LQIHFWLRQV FDXVHG DERXW PLOOLRQ FDVHV RI VHYHUH GLVHDVH DQG PRUH WKDQ GHDWKV LQ FKLOGUHQ EHORZ WKH DJHRIILYHZLWKWKHPDMRULW\RIGHDWKVRFFXUULQJLQ GHYHORSLQJ FRXQWULHV :RUOG +HDOWK 2UJDQL]DWLRQ :HKDYHFKRVHQStreptococcus pneumoniaeEDVHG RQ LWV FRPSOH[ ELRORJLFDO VWUXFWXUH ZLGHVSUHDG SUHYDOHQFH DQG WR VRPH H[WHQW RYHUORRNHG VHULRXVQHVV 7KHUH LV WR WKH EHVW RI RXU NQRZOHGJH QR FRPSDUDEOH YLVXDO LQWHUSUHWDWLRQ LQ WKHVFLHQWLILFOLWHUDWXUH\HW GHVLJQ DUH RIWHQ PDGH XQFRQVFLRXVO\ DQG URXWLQH YLVXDOLVDWLRQV DUH SUHGRPLQDQWO\ FRPSRVHG IURP VWDQGDUG VRIWZDUH SDFNDJHV GHYHORSHG E\ FRPSXWHU VFLHQWLVWV :H H[SORUH ZKDW LI DQ\WKLQJ GUDZLQJV ZDWHUFRORXUV DQG FRPSXWHUDVVLVWHG UHSUHVHQWDWLRQVZLOODGGWRRXUVFLHQWLILFNQRZOHGJH RIStreptococcuspneumoniae 7KHQDQRVFDOHZRUOGRIPROHFXOHVLVLQYLVLEOHWRWKH QDNHGH\H ,QIDFWPROHFXOHVDUHVPDOOHUWKDQ WKH ZDYHOHQJWKRIOLJKWZKLFKPHDQVWKDWZHFDQ¶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interior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treptococcus pneumoniae )DU IURP EHLQJ D W\SLFDO WH[WERRN GLDJUDP 'DYLG *RRGVHOO¶V LPDJHV GLVSOD\ RUJDQL]HG DFWLYLW\ SUHVHQWLQJ PDQ\ RI WKH SURFHVVHV LQ FHOOV )LJXUH :H ZLOO DSSO\ WKH VDPH QDUUDWLYH GHVLJQ E\ H[SODLQLQJ WKH VWUXFWXUDO HOHPHQWV RI Streptococcus pneumoniae VXFK DV SURWHLQV QXFOHLF DFLGV SRO\VDFFKDULGHV DQG OLSLG PHPEUDQHV LQ WHUPV RI PROHFXODU LQWHUDFWLRQV DQG SURFHVVHV 6LQFH WKLV KDV QHYHU EHHQ GRQH EHIRUH ZH KRSH WR VWLPXODWH QHZ VFLHQWLILF WKRXJKWV DERXW WKH LQQHU OLIH RI WKLV SDUWLFXODUEDFWHULXP 3. STREPTOCOCCUS PNEUMONIAE Streptococcus pneumoniaeLVRQHRIWKHIRXUPRVW IUHTXHQW PLFURELDO NLOOHUV ZRUOGZLGH )LJXUH ,W FDXVHV D ZLGH UDQJH RI VHULRXV GLVHDVHV VXFK DV PHQLQJLWLV VHSWLFDHPLD DQG SQHXPRQLD DQG OHVV VHULRXV RQHV VXFK DV RWLWLV PHGLD VLQXVLWLV DQG EURQFKLWLV %HN7KRPVHQ 6¡UHQVHQ ,W¶V IRXQG LQ WKH KXPDQ XSSHU UHVSLUDWRU\ V\VWHP DQG WKH KXPDQ QDVRSKDU\Q[ LV WKH RQO\ QDWXUDO VHWWLQJIRULW $FFRUGLQJ WR WKH :RUOG +HDOWK 2UJDQL]DWLRQ WKH PRVW FRPPRQ VHYHUH LQIHFWLRQ FDXVHG E\ WKH EDFWHULD LV SQHXPRQLD DFFRXQWLQJ IRU PRUH WKDQ Figure 2: A Mycoplasma mycoides cell (Illustration by David S. Goodsell, the Scripps Research Institute, 2011) 7R LOOXVWUDWH WKH VWRU\WHOOLQJ SRWHQWLDO RI RXU YLVXDOLVDWLRQ RI Streptococcus pneumoniae ZH SUHVHQW WZR H[DPSOHV RI W\SLFDO PROHFXODU QDUUDWLYHV7KHWZRIROORZLQJH[DPSOHVDUHDGRSWHG Seeing VWUHSWRFRFFXVSQHXPRQLDHa common killer bacteria Rikke Schmidt Kjærgaard & Ebbe Sloth Andersen IURP DQG EDVHG RQ 'DYLG *RRGVHOO¶V LPDJH RI WKH P\FRSODVPDP\FRLGHVFHOO 4.1 Protein synthesis 3URWHLQV\QWKHVLVLVWKHSURFHVVZKHUHFHOOVFUHDWH QHZ SURWHLQV $ GHWDLO IURP ILJXUH LOOXVWUDWHV WKH SURFHVV RI EXLOGLQJ QHZ SURWHLQV )LJXUH 7KH JHQHWLF FRGH LV VWRUHG LQ '1$ $ 6RFDOOHG WRSRLVRPHUDVH%DVVLVWVDV51$SRO\PHUDVH& ORRVHQVWKH'1$DQGEXLOGVDPHVVHQJHU51$' 5LERVRPHV ( ODUJH DQG FRPSOH[ PROHFXODU PDFKLQHV OLQN DPLQR DFLGV WRJHWKHU LQ WKH RUGHU VSHFLILHG E\ PHVVHQJHU 51$ PROHFXOHV DQG WUDQVIHU51$) Figure 4: Detail of Figure 2, indicating some of the molecules involved in powering the cell 5. COLLECTING THE DATA: ASSEMBLING THE STRUCTURE 7DNLQJDGYDQWDJHRISUHYLRXVDUWLVWLFUHQGHULQJVRI FHOO HQYLURQPHQWV *RRGVHOO 3ROODUG et al. DQG UHVRXUFHV VXFK DV WKH 5&6% 3URWHLQ 'DWD %DQN ZZZUFVERUJ ZH ZLOO SURGXFH YLVXDO UHSUHVHQWDWLRQV RI DOO QHFHVVDU\ PROHFXOHV DQG FHOOXODU HOHPHQWV SUHVHQW LQ Streptococcus pneumoniae:HZLOOLQFOXGHWKHSURSHUQXPEHURI PROHFXOHV LQ WKH ULJKW SODFHV DQG KDYLQJ WKH VFLHQWLILFDFFXUDWHSURSRUWLRQV Figure 3: Detail of Figure 2, showing some of the molecules involved in protein synthesis in a bacterial cell 5.1 Scientific resources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roducing energy $QRWKHU H[DPSOH RI D QDUUDWLYH YLWDO WR WKH OLYLQJ EDFWHULD LV WKH SURGXFWLRQ RI HQHUJ\ LQ WKH FHOO $QRWKHUGHWDLOIURP)LJXUHKLJKOLJKWVVRPHRIWKH PROHFXOHVLQYROYHGLQSURGXFLQJHQHUJ\)LJXUH *O\FRO\WLF HQ]\PHV $ EUHDN GRZQ VXJDU DQG SURGXFH$73DGHQRVLQHWULSKRVSKDWHWKHHQHUJ\ VRXUFH RI FHOOV 7KH $73 V\QWKDVH % FRQVLVWV RI DQ HQ]\PH D PROHFXODU PRWRU DQ LRQ SXPS DQG DQRWKHUPROHFXODUPRWRUDOORIZKLFKFRQVWLWXWHVD QDQRVFDOHPDFKLQHSURGXFLQJHQHUJ\ Seeing VWUHSWRFRFFXVSQHXPRQLDHa common killer bacteria Rikke Schmidt Kjærgaard & Ebbe Sloth Andersen Table 1: A short list of examples of visual representations from different scientific sources. The first column names the molecule; the second column lists the entries in the RCSB Protein Data Bank (www.rcsb.org); the third column shows the structures drawn by computer graphics adopted from 5&6%3'%, and the fourth columnshows sketches of the structures as these will appear in our drawing. We use a simplified structure in the final visualisation of Streptococcus pneumoniae. The structures are represented in grey scale to avoid visual distraction. Molecule Scientific resource PDB entries '1$ Structure drawing Sketches 1bna 1fka; 1fjg 5LERVRPH VPDOOVXEXQLW 5LERVRPH ODUJHVXEXQLW 1ffk $73 V\QWKDVH 1c17; 1e79; 2a7u; 1l2p YDULDWLRQV RI Streptococcus pneumoniae FKDUDFWHUL]HG E\ WKHLU GLIIHUHQW SRO\VDFFKDULGH FDSVXOH %\ XVH RI LPPXQHHOHFWURQ PLFURVFRS\ 6¡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± PP HYHQ ZLWKRXW WKH SLOL PDNHV LW GLIILFXOW WR GUDZ HYHU\ PROHFXOH VKRZLQJ HDFK DWRP UHSUHVHQWHG E\ D VSKHUH ,QVWHDG ZH XVH D VLPSOLILHG VSDFHILOOLQJ UHSUHVHQWDWLRQ DGRSWHG IURP 'DYLG *RRGVHOO FDWFKLQJ WKH RYHUDOO VKDSH RI HDFK PROHFXOH ZLWKRXW QHFHVVDULO\ VKRZLQJ WKH ORFDWLRQ RI HYHU\ DWRP7DEOH 6.2 Visual concepts $NH\FKDOOHQJHLVWRGHVLJQDQHQYLURQPHQWEDVHG RQDFWXDOUDZGDWDUDWKHUWKDQDSSUR[LPDWLRQVDQG WR EH DEOH WR KDQGOH JUHDW GLIIHUHQFHV LQ VSDWLDO VFDOH ,Q UHVHDUFK VHWWLQJV WKH UHODWLRQVKLS EHWZHHQ D VLQJOH PROHFXOH DQG RWKHU PROHFXOHV DQG LWV HIIHFWV RQ DQ HQWLUH RUJDQLVP LV RIWHQ LPSOLFLW 6.1 Molecular architecture of the cell wall 7\SLFDOO\ 6WUHSWRFRFFXV SQHXPRQLDH LV IRXQG DV WZR FHOOV VKDULQJ SDUWV RI WKHLU FHOO ZDOO 7KH FHOOV DUH HQFORVHG FRPSOHWHO\ E\ D SRO\VDFFKDULGH FDSVXOH 6R IDU WKHUH DUH IRXQG GLVWLQFWLYH Seeing VWUHSWRFRFFXVSQHXPRQLDHa common killer bacteria Rikke Schmidt Kjærgaard & Ebbe Sloth Andersen 7. FUTURE PERSPECTIVES 9. REFERENCES 7KH GHWDLOHG PDS RI Streptococcus pneumoniae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enetic Diversity and Relationships of 6WUHSWRFRFFXV SQHXPRQLD and its Close Commensal relatives $DUKXV 8QLYHUVLW\ $DUKXV3K''LVVHUWDWLRQ 8. ACKNOWLEDGEMENTS :RUOG +HDOWK 2UJDQL]DWLRQ 0HDVXULQJ LPSDFW RI 6WUHSWRFRFFXV SQHXPRQLDH DQG +HHPRSKLOXV LQIOXHQ]DH W\SH E FRQMXJDWH KWWSZZZZKRLQWYDFFLQHV YDFFLQDWLRQ GRFXPHQWVUHWULHYHG0DUFK *RRGVHOO ' 6 The Machinery of Life QG 6SULQJHU1HZ<RUN86$ HGLWLRQ +LOOHULQJPDQQ 0 et al. 0ROHFXODU DUFKLWHFWXUH RI Streptococcus pneumoniae 7,*5 SLOLThe EMBO Journal± /DQGHU ( 6 et al. ,QLWLDO VHTXHQFLQJ DQG DQDO\VLV RIWKH KXPDQJHQRPH Nature ± 3ROODUG7'et al. Cell Biology6DXQGHUV (OVHYLHU3KLODGHOSKLD 6¡UHQVHQ 8 % 6 et al. 8OWUDVWUXFWXUDO ORFDWLRQ RI FDSVXOHV FHOO ZDOO SRO\VDFFKDULGH FHOO ZDOO SURWHLQV DQG ) DQWLJHQ LQ SQHXPRFRFFL Infection and Immunity± :H DUH JUDWHIXO WR 3URIHVVRU 0RJHQV .LOOLDQ DQG 3URIHVVRU 8IIH % 6NRY 6¡UHQVHQ IRU HOHFWURQ PLFURJUDSK PDWHULDO DQG GHWDLOHG GLVFXVVLRQV RQ WKHELRORJ\RIStreptococcus pneumoniae
© Copyright 2026 Paperzz