CON TENT
Preface
Najib Al Khaja
Editorial
Mahmoud Taleb Al Ali
1
Genetic Disorders in Arabs
10
Ghazi Omar Tadmouri
Historical Primer
Genetic Disorders in World Populations
Arab Populations: A Definition
Major Prehistoric Events
The Early Farmers
Major Events in Ancient and Medieval History
Landmarks of Modern History
Arab Diaspora
Demographic and Medico-Economic Characteristics of Arab Populations
Health Care in the Arab World
Outlook of Genetic Research in the Region
Consanguinity in Arab People
The CTGA Database
Genetic Disorders in Arab Populations
The Spectrum of Disease and Gene Diversity in Arab Populations
The Economic Impact of Genetic Disorders
Preventive Aspects of Genetic Disorders in Arabs
Genetic Disorders Prevention Programs in Arab States
Arab Family Perception of Genetic Disorders
Conclusive Remarks
2
Consanguineous Marriages and their Effect on Common Diseases in the Qatari
Population
30
Abdulbari Bener
Summary
Background
Prevalence of Consanguineous Marriages in Qatar
Effects of Consanguineous Marriages on Specific Illnesses in Qatar
Impact of Consanguinity on Cancer in a Highly Endogamous Population
Autosomal Recessive Disorders and Consanguineous Marriages
Limitations and Suggestions for Further Research and Action
Conclusion
3
Genetic Disorders in Qatar: A CTGA Perspective
Pratibha Nair, Tasneem Obeid, Ghazi Omar Tadmouri
Introduction
Medical Services in Qatar
Genetic Services in Qatar
Biomedical Research in Qatar
Genetic Disorders in the Arab Population of Qatar
Disease and Gene Diversity in Qatar and Neighboring Countries
Concluding Remarks
40
4
5
6
Genetic Disorders in Arab Populations: Qatar
Tawfeg Ben-Omran, Atqah Abdul Wahab
60
Introduction
Historical Background
Current Genetic Facilities in Qatar
Consanguineous Marriages and their Implications in Qatar
Reported Genetic Disorders in Qatar
Monogenic Disorders
Inborn Errors of Metabolism (IEM)
Endocrine Disorders
Hemoglobinopathies
Miscellaneous Disorders/Syndromes
Genetic Disorders in Qatar
Jiangxuan Shan, Rebecca Mathew, Khalad Al-Ali, Lotfi Chouchane
66
Introduction
The Geography and Ethnography of Qatar
Genetic Services and Neonatal Screening Centers in Qatar
Consanguinity
Genetic and Congenital Disorders
Red Cell Genetic Disorders
Bleeding Disorders
Chromosomal Disorders
X-Linked Disorders
Genetic Endocrine Disorders
Metabolic and Nutritional Diseases
Connective Tissue Disorders
Dermatological Disorders
Eye Disorders
Cancer
Conclusion
Initial Results of a Pilot Arab Human Variome Project
Tasneem Obeid, Ghazi Omar Tadmouri
74
Introduction
Country-Level Gene Variation: The State of Qatar
Disease-Level Gene Variation: Beta-Thalassemia
The Shallow Infonome and the Lost Opportunities
The Deep Infonome and the Lessons to be Learned
Appendix 1
Appendix 2
102