This Accepted Manuscript has not been copyedited and formatted. The final version may differ from this version.
Research Articles: Cellular/Molecular
Neuronal chloride regulation via KCC2 is modulated through a GABAB receptor
protein complex
Rebecca Wright1,4, Sarah E. Newey1,4, Andrei Ilie1, Winnie Wefelmeyer1, Joseph V. Raimondo1, Rachel Ginham2, R.
A. Jeffrey Mcllhinney2 and Colin J. Akerman1
1
Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK
2
MRC Anatomical Neuropharmacology Unit, Mansfield Road, Oxford, OX1 3TH, UK
DOI: 10.1523/JNEUROSCI.2164-16.2017
Received: 6 July 2016
Revised: 31 March 2017
Accepted: 6 April 2017
Published: 27 April 2017
Author contributions: R.W., S.N., A.I., R.J.M., and C.J.A. designed research; R.W., S.N., A.I., W.W., J.V.R.,
and R.J.M. performed research; R.W., S.N., A.I., W.W., J.V.R., R.J.M., and C.J.A. analyzed data; R.W., S.N.,
A.I., R.J.M., and C.J.A. wrote the paper; R.D. contributed unpublished reagents/analytic tools.
4
These authors contributed equally to this work
We would like to thank Piotr Bregestovski (INMED, Marseille) for the generous gift of Cl-Sensor cDNA, Demelza
Vinnicombe for technical assistance and Julia White for her support and help. This work was supported by
grants from the Medical Research Council (G0601503) and the Biotechnology and Biological Sciences Research
Council (BB/E0154761). The research leading to these results has received funding from the European
Research Council under the European Community's Seventh Framework Programme (FP7/2007-2013), ERC
grant agreement number 243273. In addition, RW, AI and WW were supported by Wellcome Trust Doctoral
Fellowships, SEN was supported by a Royal Society Dorothy Hodgkin Fellowship, JVR was supported by the
Rhodes Trust, RG was supported by a GlaxoSmitKline Studentship and RAJM was supported by the Medical
Research Council.
Correspondence: [email protected] +44 (0)1865 271872
Cite as: J. Neurosci ; 10.1523/JNEUROSCI.2164-16.2017
Alerts: Sign up at www.jneurosci.org/cgi/alerts to receive customized email alerts when the fully formatted
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This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International
license, which permits unrestricted use, distribution and reproduction in any medium provided that the original
work is properly attributed.
Accepted manuscripts are peer-reviewed but have not been through the copyediting, formatting, or proofreading
process.
Copyright © 2017 Wright et al.
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