Clinpro
Tooth
Crème
Clinpro Tooth Crème
™
™
Clinpro Tooth Crème
™
0.21%
w/w
Sodium
Fluoride Anti-Cavity Paste
0.21% w/w Sodium Fluoride
with
Functionalised
Tri-Calcium
Phosphate
0.21%
w/wPaste
Sodium
Anti-Cavity
withFluoride
Tri-Calcium Phosphate
Anti-Cavity Paste with Tri-Calcium Phosphate
Winning
Winning Formula
Formula
Helps
HelpsPrevent
PreventCavities
Caries
With Innovative
With Innovative
Tri-Calcium
Tri-Calcium
Phosphate
Phosphate
Exclusively
ExclusivelyFrom
From3M
3MESPE
ESPE
Introducing Clinpro Tooth Crème,
the
winning Clinpro
formula Tooth
that helps
Introducing
Crème,
prevent
caries.
the winning
formula that helps
prevent
cavities.
The
Importance
of functionalised Tri-Calcium
™
™
™
™
Phosphate in Clinpro Tooth Crème
Strengthens teeth and reverses white spot
It has been well proven and documented that calcium alone will not prevent caries but
lesions better than the leading brand
calcium and fluoride will. The difficulty with preparations that combine calcium and
Clinpro isTooth
Crème 0.21%
Sodium
Fluoride
Anti-Cavity
Paste is
an fluoride.
advancedThese
fluoride
the potential
for thew/w
calcium
oxides
to interact
undesirably
with
™
formula containing
innovative
tri-calcium
ingredient
and is
available
interactions
have theanability
to render
both thephosphate
calcium and
the fluoride
inactive
and can
exclusively
from
3M
ESPE.
This
winning
formula
is
a
one-step
process
requiring
patients
to
impact on the amount of bioavailable calcium and fluoride to the teeth.
simply brush
it once
daily,
eliminating
the two-step
regimenPaste
currently
Clinpro
Tooth with
Crème
0.21%
w/w
Sodium Fluoride
Anti-cavity
is anassociated
advanced with
™delivers more
GC Toothcontaining
Mousso Plus*.
Clinprofunctionalised
Tooth Crème also
fluoride,
helps
formula
innovative
Tri-Calcium
Phospate
(fTCP)
andstrengthen
is available
Introducing
Clinpro
Tooth
Crème,
enamel andfrom
helps3M
reverse
than
Tooth Mousso
Plus.
exclusively
ESPE.white
fTCP spot
is thelesions
name better
given to
theGC
innovative
calcium-based
the
winning
that
helps
additive used
in Clinpro Tooth formula
Crème. One of the major
components
of the additive is TriCalcium Phosphate.cavities.
prevent
% Change in Surface
Fluoride Uptake
1
Strengthens teeth and reverses white spot
milling
40 process, Tri-Calcium Phosphate is functionalised resulting in an organic-calcium
120%
lesions
better than the leading brand
micrograms F / surface of enamel
™
1
What makes Clinpro Tooth Crème so innovative is the way in which Tri-Calcium Phosphate
Microhardness [Mean +/- SEM]
[Mean +/- SEM]
is prepared
to allow it to co-exist with fluoride in an140%
aqueous environment. During the
45
35
phosphate
hybrid being formed. This importantly ensures that the calcium oxides are
100%
Clinpro
Tooth
0.21% w/winteractions
Sodium Fluoride
Anti-Cavity
PasteClinpro
is an advanced
30
protected fromCrème
the undesirable
with fluoride,
allowing
Tooth Crème to
% change in SMH
™
80%ingredient and is available
formula
25 containing an innovative tri-calcium phosphate
deliver
more bioavailable fluoride and calcium to the teeth.
20
exclusively
fromCrème
3M ESPE.
This winning
formula
is a one-step
requiring
patients
60% process
Clinpro Tooth
is a simple
one-step
regimen
requiring
patients
to simply
brushtowith
than the leading
products
•Contains
0.21% w/w
Sodium
Fluoride
• Prevents cavities
(950 ppm fluoride ion)
• Reduces root cavities
•Contains an exclusive and
• Contains
0.21%
w/wand
innovative
calcium
(950
ppm
fl
uoride
ion)
phosphate ingredient
••Gentle,
Containseffective
an innovative
cleaning
calcium and phosphate
•Cleans
and whitens teeth
ingredient
Summary
of Advantages:
•Low
abrasion
Gentle,
effective
cleaning
••Delivers
more
fluoride
to
•Replaces
conventional
toothand whitens teeth
•the
Cleans
toothpaste regimen
••Strengthens
teeth better than
Low abrasion
•Available
a convenient
the leadinginproducts
• Replaces
conventional
113g flip-top
tube
• Reverses
spots better
toothpastewhite
regimen
•than
Simple
one-stepproducts
regimen
the leading
• Available in a convenient
• Prevents
cavities
113g flip-top
tube
• Reduces root cavities
cpTC_brochure_102808r1.indd 2
• Contains 0.21% w/w
(950 ppm fluoride ion)
cpTC_brochure_102808r1.indd 2
20%
5
enamel
and helps of
reverse
white spot
better
than GCimproved
Tooth Mousso
Plus.
the performance
both calcium
andlesions
fluoride
to provide
fluoride
delivery,
0
0%
Mousse
Tooth Crème
strengthening
of enamel Clinpro
and
reversal
of white spot lesions.
900 ppm F0.21% w/w Sodium
Fluoride
Uptake
Clinpro Fluoride
Tooth Crème
0.21% w/w
[Mean
+/SEM] Tooth Paste
Sodium Fluoride Anti-Cavity
™
45
40
1
140%
delivers more fluoride to the tooth!
Clinpro Tooth Crème
0.21% w/w Sodium
Fluoride
Change
in Surface
Crème
0.21% w/w
Clinpro% Tooth
Microhardness
[Mean
+/- Tooth
SEM]
Sodium Fluoride Anti-Cavity
Paste strengthens teeth better!
1
120%
35
30
25
20
15
10
Item #
5
12216
0
Mousse
900 ppm F™
% change in SMH
Summary
Advantages:
•Providesofimproved
fluoride
delivery,
strengthening
• Delivers more fluoride toof
enamel
the
tooth& reversal of white
spot lesions
• Strengthens teeth better than
•Prevents
cavities
the leading
products
cavities
••Reduces
Reverses root
white
spots better
15
simply
it once
thetooth
two-step
regimen
currently
with
it twicebrush
dailywith
in place
of daily,
their eliminating
conventional
paste
(eliminating
the associated
two-step regimen
40%
10
GC
Tooth Mousso
Plus*.products).
Clinpro Tooth
Crème
alsoCrème’s
delivers more
fluoride,
strengthen
associated
with other
Clinpro
Tooth
innovative
fTCPhelps
formula
maximises
micrograms F / surface of enamel
Summary of Clinpro Tooth
Creme Advantages:
Mousse +
[CPP-ACP
900 ppm FF¯]
Clinpro Tooth Crème
0.21% w/w Sodium
Fluoride
™
Clinpro
Tooth
0.21%
Clinpro Tooth
CrèmeCrème
0.21% w/w
SodiumSodium
Fluoride Anti-Cavity
w/w
FluorideTooth
Anti-Paste
delivers Paste
more fluoride
to the fluoride
tooth!
Cavity
improves
delivery
to the tooth
1. 3M internal
data on file.
™
1. 3M internal data on file
100%
80%
60%
40%
Product Information
20% ™ Tooth Crème 0.21% Sodium Fluoride
Clinpro
Anti-Cavity Paste with Tri-Calcium Phosphate
113g0%
tube, vanilla mint flavor
[CPP-ACP
Mousse +
900 ppm
ppm FF¯]
Clinpro Tooth Crème
0.21% w/w Sodium
Fluoride
™
Clinpro
Tooth
0.21%
CrèmeCrème
0.21% w/w
Clinpro Tooth
SodiumSodium
Fluoride Anti-Cavity
w/w
FluorideTooth
AntiPaste strengthens
teeth better!
Cavity
Paste offers
improved
strengthening of teeth
™
21/1/09 3:47:55 PM
21/1/09 3:47:55 PM
An enhanced option
FF-
CaOn
Ca
The optimised formula of Clinpro Tooth Crème makes for an outstanding choice. It contains
CaO
C
aOn
CaOn
CaO
F-
F-
This proprietary formula successfully integrates these components, enhancing, rather than
FF-
CaOn
Ca
CaO
C
aOn
barrier is created around the calcium allowing it to coexist with the fluoride ions. As Clinpro
CaO
C
On
F-
CaO
C
Ca
aO
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CaO
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C
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Tooth Crème comes in contact with saliva during brushing, the barrier breaks down and
F-
CaO
C
aO
On
CaO
On
F-
fluoride as well as calcium and phosphate, which are components naturally found in saliva.
compromising, the product’s performance. During the manufacturing process, a protective
CaO
C
Ca
aO
On
CaO
On
CaOn
Ca
CaO
C
aO
On
FF-
makes the calcium, phosphate and fluoride readily available to the tooth. The tooth naturally
absorbs these components, helping to prevent the initiation and further progression of
demineralisation and allowing remineralisation to occur.
F-
FCaOn
Ca
F-
Teamwork for better results
CaO
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CaO
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Phosphate formula is the result of a relationship between 3M ESPE and Indiana Nanotech
CaOn
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The development of this innovative 950 ppm fluoride and functionalised Tri-calcium
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scientists. 3M ESPE enlisted world-renowned and expert caries researchers to become
part of the development team. Key players included Dr. George Stookey, a pioneer in
caries research and key contributor to developing the world’s first clinically proven fluoride
toothpaste, Dr. Robert Karlinsey, an emerging leader in developing dental and biomedical
Saliva activates the calcium compound,
breaking down the protective coating and
making it available to the tooth.
technology applications, and the 3M ESPE Preventive Research Team led by Aaron Pfarrer.
Discover the benefits
Practicing dental professionals and industry experts alike will discover the breakthrough
benefits of Clinpro Tooth Crème. Your patients should, too. The winning formula for caries
prevention is now available.
cpTC_brochure_102808r1.indd 3
Patient compliance can be a challenge.
Dispensing the one-step regime of
Clinpro Tooth Crème 0.21% w/w
Sodium Fluoride Anti-Cavity Paste from
your surgery is good for your patients
and your practice.
™
21/1/09 3:47:56 PM
What Supportive Documentation is Available?
Solid-state Preparation and Dental Application of an Organically Modified Calcium Phosphate
Robert L. Karlinsey Æ Allen C. Mackey – Journal of Materials, 2009
Dilution-Dependent Fluoride Release from NaF Dentifrices Containing Unique Forms of Calcium
Karlinsey, Pfarrer, Stookey, Caries Res (2008) 42(Abstr 135):231
2008 ORCA Meeting
In Vitro Remineralisation of White-Spot Enamel Lesions from NaF Dentifrices with & without Calcium
Karlinsey, Mackey, Pfarrer, Stookey, Caries Res (2008) 42(Abstr 137):232.
2008 ORCA Meeting
Enamel Remineralisation and Fluoride uptake from 5000 ppm Fluoride Pastes Karlinsey, Mackey, Pfarrer, Stookey, J Dent Res
(2008) 87 (Spec Iss A) Abstr 894. Karlinsey, Frederick, Mackey, Stookey, Pfarrer, J Dent Res (2008) 87(Spec Iss A) Abstr 109.
Challenges of Implementing New Remineralisation Technologies
ICNARA Conference – 2008 A. M. Pfarrer, R. L. Karlinsey
In Vitro Assessment of Dentine Tubule Occlusion by Hypersensitivity Dentifrices
A.C. MACKEY1, R.L. KARLINSEY1, J. GIDLEY1, G. STOOKEY1, and A. PFARRER2, 1Indiana Nanotech, Indianapolis, IN,
23M ESPE Dental Products, St. Paul, MN IADR Abstract – 2009
In Vitro Remineralisation Efficacy of NaF Systems Containing Unique Forms of Calcium: a pilot study.
Robert.L. Karlinsey1, Allen C.Mackey, George K. Stookey1, 1Indiana Nanotech, Indianapolis. American Journal of Dentistry (In
Press)
In Vitro Assessments of Experimental NaF Dentifrices Containing a Prospective Calcium Phosphate Technology
Robert.L. Karlinsey1, Allen C.Mackey, George K. Stookey2, Aaron M. Pfarrer3
1Indiana Nanotech, Indianapolis., IN. 2Therametric Technologies Inc, Indianapolis, IN, 33M ESPE Preventive Care, St.Paul, MN
American Journal of Dentistry – (In Press)
Directions for Use
Use a
pea-size
amount
1
Brush for
2 minutes
2
3
Rinse and
spit
Use twice
daily or as
directed by
your dental
professional
4
Clinpro Tooth Crème 0.21% w/w Sodium Fluoride Anti-Cavity Paste with functionalised
Tri-Calcium Phosphate
™
Item #
12216
Product Information
Clinpro Tooth Crème 0.21% Sodium Fluoride Anti-Cavity Paste with functionalised Tri-Calcium Phosphate
™
113g tube, vanilla mint flavour
Dental Products
3M New Zealand Ltd
94 Apollo Drive
Albany, North Shore City 0632
Auckland.
www.3MESPE.co.nz
3M, ESPE and Clinpro are trademarks
of 3M or 3M ESPE AG. Please recycle.
© 3M 2010. All rights reserved.