Anti-VDAC1 monoclonal antibody, clone 31C23
Cat.No: DCABH-6193
Lot. No. (See product label)
PRODUCT INFORMATION
Product Overview
Mouse monoclonal to VDAC1 / Porin - Azide free
Antigen Description
Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The
channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the
plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open
conformation at low or zero membrane potential and a closed conformation at potentials above 30-40
mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May
participate in the formation of the permeability transition pore complex (PTPC) responsible for the
release of mitochondrial products that triggers apoptosis.
Immunogen
Recombinant full length protein corresponding to Human VDAC1/ Porin.
Isotype
IgG
Source/Host
Mouse
Species Reactivity
Mouse, Rat, Human, Fruit fly
Clone
31C23
Purity
IgG fraction
Conjugate
Unconjugated
Applications
WB, IHC-P, Flow Cyt, ICC/IF, ICC
Format
Liquid
Size
1 mg
Buffer
Constituents: HEPES, Sodium chloride
Storage
Store at -20°C long term.
Ship
Shipped on Dry Ice.
Antigen Gene Information
Gene Name
VDAC1 voltage-dependent anion channel 1 [ Homo sapiens ]
Official Symbol
VDAC1
Synonyms
VDAC1; voltage-dependent anion channel 1; voltage-dependent anion-selective channel protein 1;
MGC111064; PORIN; porin 31HL; porin 31HM; plasmalemmal porin; outer mitochondrial membrane
protein porin 1; VDAC-1;
Entrez Gene ID
7416
mRNA Refseq
NM_003374
Protein Refseq
NP_003365
MIM
604492
Creative Diagnostics. All rights reserved
45-1 Ramsey Road Shirley, NY 11967, USA
Tel: 1-631-624-4882 Fax: 1-631-938-8221
E-mail: [email protected]
www.creative-diagnostics.com
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UniProt ID
B3KTS5
Chromosome Location 5q31
Pathway
Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved
biosystem; HTLV-I infection, organism-specific biosystem; HTLV-I infection, conserved biosystem;
Huntingtons disease, organism-specific biosystem; Huntingtons disease, conserved biosystem;
Influenza A, organism-specific biosystem;
Function
porin activity; protein binding; voltage-gated anion channel activity; voltage-gated anion channel
activity;
Creative Diagnostics. All rights reserved
45-1 Ramsey Road Shirley, NY 11967, USA
Tel: 1-631-624-4882 Fax: 1-631-938-8221
E-mail: [email protected]
www.creative-diagnostics.com
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