International Journal of Life Sciences Biotechnology and Pharma Research Vol. 4, No. 2, April 2015 Bionics Based Solar Powered Clothing for Treating Parkinson’s Disease and Epilepsy Shweta Gupta Electronics and Communication Department, Dr. K. N. Modi University, Newai, Rajasthan, India Shivakar and Vinay Kumar Singh Applied Science Department, Dr. K. N. MIET, Modinagar, India Email: [email protected] Abstract—This research paper incorporates bionics based solar powered clothing for treatment of Parkinson’s disease and Epilepsy. Firstly, the clothing will use the most recent research and technology in which the electronic circuit would be embedded to store data (such as tremors of Parkinson’s disease and Epilepsy) and deliver drugs to specific parts of the brain, thus, preventing the cumbersome method of surgery by the method of neurostimulator. Secondly, the electronic circuit will be charged by solar source of energy. This research paper involves bionic based UV-treated natural fiber fabric, such as cotton or linen, in which electronic circuit is embedded with, nanomaterials based, sensors (to sense the tremors and body temperature), drug delivery components and memory to provide stimulation to specific regions of the brain to treat Parkinson’s disease and epilepsy. These fabrics are worn on the head to treat the brain diseases. These fabrics work two way, they sense the tremors by tension and compression of the muscle and then, deliver medicine through the skin to appropriate regions of the brain. as shown in Fig. 1. Parkinson’s disease is a slowly progressive disorder that affects movement, muscle control, and balance [3]. Part of the disease process develops as cells are destroyed in certain parts of the brain stem, particularly the crescent-shaped cell mass known as the substantia nigra. Figure 1. Substantia Nigra region of brain. Index Terms—solar powered clothing, Parkinson’s disease, epilepsy, bionics, neurostimulator If we go deeper in the study of the cause of the disease, then, it is due to accumulation of a protein called alphasynuclein into inclusions called Lewy bodies in neurons and the dopamine protein is insufficiently formed in neurons of the midbrain. Early in the course of the disease, the most obvious symptoms are movementrelated shaking, rigidity, slowness of movement and difficulty with walking as shown in Fig. 2. Other symptoms include sensory, sleep and emotional problems. Later, thinking and behavioral problems may arise. Epilepsy is a common and diverse set of chronic neurological disorders characterized by seizures (fits). Epilepsy requires that seizures not be recurrent and unprovoked. It is at times not cured, with medication, thus Deep Brain Stimulation (Neurostimulators) is used as shown in Fig. 3. But Neurostimulators is the form of surgery in the body, with benefits as well as risks. Few benefits are significant and sustained reduction in chronic pain improved ability to function and participate in activities of daily living, less oral pain medications. It is proven safe and effective when used as directed. It is tested in studies worldwide. Reversible and non-destructive – the therapy can be turned off or surgically removed [4]. I. INTRODUCTION Bionics is a branch of science which involves the application of biological methods and systems which we see in nature like birds flying etc. and we, thus, developed aeroplanes and other engineering systems and modern technology. Examples of bionics in engineering include the hulls of boats imitating the thick skin of dolphins; sonar, radar, and medical ultrasound imaging imitating the echolocation of bats [1]. In the field of electronics, the study of bionics has produced artificial neurons, artificial neural networks, and intelligence. How can bionics be helpful in harnessing solar energy, can be the fact, we studied how nature based polymer is used to make the fabric that provides for the charging of the polymer embedded electronic circuit [2]. Parkinson’s disease is the degenerative disorder of the brain. Its main cause is the death of the dopamine generating cells in the mid brain, known as Substantia Nigra region of the brain in the central nervous system, Manuscript received January 4, 2015; revised March 2, 2015 ©2015 Int. J. Life Sci. Biotech. Pharm. Res. 132 International Journal of Life Sciences Biotechnology and Pharma Research Vol. 4, No. 2, April 2015 energy into electrical energy to charge the polymer embedded electronic circuit. We use silicon based organic polymer to make Solar Powered Clothing. Figure 2. People suffering from Parkinson’s disease. Figure 4. Internal architecture of wireless Closed Deep Brain Stimulation (CDBS). Figure 3. Implantable neurostimulator. Risks in Neurostimulation involves neurostimulation implant, surgically placed under the skin so surgical complications are possible and may include infection, pain at the site of surgery, and bleeding into the epidural space. Once the neurostimulation system is implanted, device complications may occur and include corrective surgery, jolting, lead breaking and movement of the lead within the epidural space which may require reprogramming or surgical replacement of the leads [5]. Instead of integrated Deep Brain Stimulation Technique (DBS), the Wireless Log-based Closed-loop Deep Brain Stimulation (CDBS) with two-way Wireless Telemetry came up as the new research as shown in Fig. 4 with its internal architecture and model as shown in Fig. 5. The device was placed under the collar bone the Scapula and the sternum. This helped to minimize tissue damage. It fits to standard tools with stable and biocompatible characteristics. Electrodes should be stiff enough to resist insertion forces during surgery and be able to position the probe channels precisely close to the small Subthalmic Nigra Region (STN) [6]. But still the cost and infection risks were there and the surgery was cumbersome. Though the number of leads reduced and device was controlled wirelessly. Thus we came up with the bionics based embedded solar photovoltaic cell based fabric that convert solar ©2015 Int. J. Life Sci. Biotech. Pharm. Res. Figure 5. Model of Closed Loop Deep Brain Stimulation (CDBS). Figure 6. Solar cells embedded fabric. Fig. 6 shows polymer embedded electronic circuit is as thin as the hair and is resistant to sweat, water damage and other wear and tear and provide stimulation to particular regions of the brain for treatment of brain diseases like Parkinson’s disease and Epilepsy. The fabric embedded electronic circuit works two ways, it can sense the tremors of Parkinson’s disease and epilepsy and then, at the same time it can pass the medicine to the specific regions of the brain to prevent the tremors. Thus, preventing the need for surgery and previously, embedding the neurostimulators in the brain which involved cumbersome method of surgery and involved the infection risks [7]. 133 International Journal of Life Sciences Biotechnology and Pharma Research Vol. 4, No. 2, April 2015 release in the body accordingly, if the symptoms are found [13]. Now comes the question of providing battery back up to the circuit. Since we know the concept of converting solar energy into electrical energy. Thus, the clothing is embedded with solar photovoltaic cells, which converts solar energy to electrical energy. The clothing is embedded with silicon nanowires [14] as shown in Fig. 9. The main aim of the solar clothing embedded with silicon wires is it’s time to put on your Wearable Solar outfit - because while it’s not the most conservative looking clothing, it’s definitely one of the most functional, avant garde pieces you can wear. We have created flexible solar photovoltaic cells that can be sewn into clothing and worn , and thus , harness solar energy and store it as electrical energy , which can further be used to charge the tattoo thin electronic circuit [8]. II. COMPOSITION The flexible, stretchable electronics, in the “closed Loop feedback system “provides the statistical analysis which helps to realize symptoms of disease and help in infusion of drug and medicine through the skin. Fig. 7 shows electronic patch is made of sensors, memory, and drug delivery components which are fabricated on the stretchable polymer substrate which is soft and flexible and resistant to water like human hair. On the top of the electronic patch, it has printed three things: silicon nonmaterial based strain sensor arrays, gold and chromium wires of nano size that act as both heaters and temperature sensors and it also has drug embedded silicon nanoparticles [9]. The sensors are used to sense tremors of Parkinson’s disease in the body. The heaters are used to infuse drug into specific parts of the brain because as tremors are sensed they reduce the bonding between nano particles and drugs, thus, drug is infused in the body. The temperature sensors, in turn, also sense the temperature of the skin during drug delivery for the prevention of any sort of burns. On the top of hair thin patch of polymer based clothing, is embedded with silicon based nanomaterial made sensors, in the form of arrays, serpentine gold and chromium nanowires that act as temperature and heat sensors, drug filled porous silica nanoparticles [10]. The sensors detect the tremors of Parkinson’s disease. The heat sensors control the temperature of polymer which help in the infusion of medicine in the body, in the specific parts of the brain (heat helps in the degradation of physical bonding between the drugs and nanoparticles) as shown in Fig. 8. The temperature sensors used along with it are used to monitor skin temperature [11]. One of the most unique part of this electronic patch is memory that is stretchable nonvolatile memory, using metal oxide nanomaterial based membranes. There are three layers of gold nanoparticles between between ultra thin titanium oxide nanomembranes printed on aluminium electrodes. The bending and twisting of memory device is not affected, even if it is twisted to 125 percent of it’s original length or even stretched about 1000 times [12]. Figure 7. Medicine and sensors embedded patch. Figure 8. Sensors and circuit embedded. Figure 9. Solar powered clothing. IV. BIOLOGICAL BACKGROUND The electronic patches powered by the Solar clothing involve the redox reactions on the surface of the skin. The ionic current flows is using the voltage gated ion channels. It results in cell polarizations by the creation of ion gradients. It involves dopant interactions with cell surface glycoprotein and ECM proteins [15]. Depending upon the surface tension and compression of the body muscles, if they match as that of Parkinson’s disease and III. WORKING This nano thin electronic patch is placed on the body, which measures the tremors of Parkinson’s disease, by measuring the compression and tension of the muscle. Thus the “closed loop electronic circuit” senses the tremors and determines whether they are Parkinson’s disease or epilepsy symptoms. And initiates the drug ©2015 Int. J. Life Sci. Biotech. Pharm. Res. 134 International Journal of Life Sciences Biotechnology and Pharma Research Vol. 4, No. 2, April 2015 TABLE I. RELATED TABLE OF SURFACE AREA VERSUS MASS ADSORBED Epilepsy, it results in dopant release and sequestration of soluble growth factors as shown in Fig. 10. Glycol in Oxidant Layer (wt.%) 0 24 68 61 Surface area (%increase) 7.6 0.7 2.8 1.5 Mass adsorbed (ng/cm2) 1371 1227 1246 1481 f/D -20.7 -15.5 -16.1 -15.8 Figure 10. Biological background of medicine induction process. Besides using silicon in the Solar Powered Clothing, we can use Organic Conductors which are Intelligent Polymers (formula shown in Figure 11), they are smarter than average polymer. Metal are harder, expensive and unable to deliver drugs. Organic Conductors are soft, ability to change properties and deliver drugs easily and inexpensive [16]. Cell interactions at surfaces are understood by protein interactions at the skin surfaces as in Fig. 12. There are two type of interactions: cell interactions and interactions under stimulus [17]. By reducing potential, increases mass adsorbed per area and results in the less hydrated, less viscoelastic protein layer as shown in Table I. Examining cell interactions mediated by protein interactions. Cell area on charged surfaces was found to be cell type dependent as shown in Fig. 13. Figure 13. Related graphs of applied potential (vs. Ag/AgCl) and mass adsorbed (ng/cm2). Fig. 14 shows 3D architecture of Wet Spinning Fibres which are eventually embedded in the Solar Powered Clothing used to charge electronic patch. Tattoo thin electronic patch uses soft, flexible materials that house a 4-centimeter long, 2-centimeter wide, 3-millimeter thick device that contains sensors, RAM capabilities, microheaters and medicine as shown in Fig. 15. The patch sticks to skin through electrostatic force as any adhesives would disrupt electrical connectivity [18]. Figure 11. Conducting polymers. Figure 14. 3D architecture of wet spinning fibres. Thus, we have successfully studied the new research for treatment of Parkinson’s disease and Epilepsy that would remove surgery and would be more patient friendly. V. CONCLUSION Thus, we have found out through the new breakthrough in technology and innovation that surgery would be replaced by electronic patches that would not only be sensing tremors of Parkinson’s disease and epilepsy but, at the same time, provide for the medication Figure 12. Procedure of interaction of extraordinary Electro materials with the skin. ©2015 Int. J. Life Sci. Biotech. Pharm. Res. 135 International Journal of Life Sciences Biotechnology and Pharma Research Vol. 4, No. 2, April 2015 [10] S. Duun, R. G. Haahr, O. Hansen, K. Birkelund, and E. V. Thomsen, “High quantum efficiency annular backside silicon photodiodes for reflectance pulse oximetry in wearable wireless body sensors,” J. Micromech. Microeng., vol. 20, no. 7, pp. 075020-075020, 2010. [11] J. 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ACKNOWLEDGEMENT The author from the depth of her heart would like to thank her parents and colleagues, with whose instigation she is able to put forward this research idea, which would be a boon for the patients of Parkinson’s disease and epilepsy and further research would work wonders and replace surgery, which has side effects and risks of infection. Shweta Gupta belongs to Meerut, Uttar Pradesh, India. She is throughout convent educated in St. Thomas English Medium, Meerut. She secured 90% in Xth standard from I.C.S.E. Board and was all India topper in chemistry in XII standard in C.B.S.E. Board. She did her engineering in electronics from Pune University from Amrutvahini College of Engineering, Sangamner, Maharashtra, India in 2002. Then, she recieved her M.S. from Bits Pilani in 2006, and got executive MBA in international business from IIM Lucknow in 2012. Presently, she is pursuing her Ph.D. in biomedical electronics, particularly in brain diseases from Dr. K. N. Modi University, Newai, Rajasthan. She worked in various colleges like M.I.E.T., Meerut, India, and several companies like Techmahindra. Presently she works in Dr. K. N. Modi Institute of Engineering and Technology, Modinagar, India. She is selected as Blind Peer reviewer recently in renouned journal “British Journal of Medicine and Medical Research. She was invited in Petroleum University Conference, UPES, Dehradun, India. And her thesis has been asked for publishing by Lap Lambert Publishing House, Germany. REFERENCES [1] [2] [3] [4] [5] [6] [7] [8] [9] J. M. Kang, T. W. Yoo, and H. C. Kim, “Bionics based wristworn integrated health monitoring instrument with a tele-reporting device for telemedicine and telecare,” IEEE Trans. Instrum. Meas., vol. 55, no. 5, pp.1655-1661, 2006. U. Anliker, J. A. Ward, P. Lukowicz, G. Troster, F. Dolveck, M. Baer, et al., “Amon: A wearable multiparameter medical monitoring and alert system,” IEEE Trans. Inf. Technol. 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His current research focuses on the CADD analysis and drug development for cancer with special reference to EGFR and consequently their application in imaging modalities. Shivakar received his Ph.D. in Mathematics and worked as the dean academics in Dr. K. N. Modi Institute of Engineering and Technology, Modinagar, Ghaziabad. 136
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