BSC 2010 0M04 Quiz (Chapter 16) ​Solutions
*Disclaimer: I have made these problems to the best of my
ability. However, this is only an overview. Not all
information/answers are guaranteed to be accurate, and this
information may or may not apply to your class exam. ☺
1. Which of the following represents a step necessary to create the lagging strand, but not
the leading strand, during DNA replication?
a. DNA ligase joins Okazaki fragments together
b. DNA polymerase synthesizes template DNA from the parent strand
c. Helicase unwinds the parental strand of DNA
d. DNA is synthesized in the 5’ to 3’ direction
2. What direction does DNA synthesis take place on the lagging strand?
a. 3’ to 5’ direction toward the replication fork
b. 5’ to 3’ direction away from the replication fork
c. 3’ to 5’ direction away from the replication fork
d. 5’ to 3’ direction toward the replication fork
3. What is the function of single-stranded binding proteins during DNA replication?
a. Recruit DNA polymerase
b. Prevent the separated strands from recoiling
c. Synthesizing RNA primers
d. Ensure both strands are replicated at similar rates
4. What is the function of a helicase enzyme during DNA replication?
a. Scan for mismatches
b. Add primers to the lagging strand
c. Fix breaks in the sugar phosphate backbone
d. Unwind the double stranded DNA
5. What is the purpose of topoisomerase during DNA replication?
a. Hold the DNA polymerases in place during replication
b. Bring new nucleotides to the replication fork
c. Cut the phosphate backbone ahead of the replication fork to prevent the DNA
from getting overwound
d. Identify unwanted isomers of nucleotides
6. What would be a direct result of a mutated, nonfunctional gene for primase in a cell?
a. Inability to replicate DNA
b. Inability to denature double-stranded DNA
c. Inability to maintain genetic fidelity
d. Inability to transcribe DNA
7. Which of the following refers to the correct model of DNA replication, where a newly
synthesized strand of DNA is half the parent strand and half newly synthesized?
a. Semiconservative
b. Dispersive
c. Conservative
d. Random
8. Which of the following proteins are not essential to DNA replication?
a. DNA ligase
b. DNA polymerase 3
c. Helicase
d. Cohesin
9. T or F. DNA polymerase can only add nucleotides to the 5’ end of the DNA strand.
a. True
b. False
10. Which of the following has the capability of catalyzing the lengthening of germ cell DNA
by adding the repetitive sequences of DNA on the ends of chromosomes (TTAGGG)?
a. Cancerous cells
b. Telomerase
c. Telomeres
d. Both A and B
e. Both B and C
11. If a primer is added to the end of lagging strand, what will be the polarity (5’ or 3’) of the
end of that primer? (Think about what direction the template strand runs in and where it
starts versus how the leading strand is built)
a. 3’
b. 5’
12. Which of the following are true regarding primers used in DNA replication?
a. RNA polymerase adds RNA primers to the new strands
b. RNA primers allow DNA polymerase to add nucleotides to the 3’ hydroxyl end
c. Each newly synthesized strand receives several primers
d. The primers are DNA primers
13. According to Chargaff’s rule, the following proportion exists in DNA.
a. C=G
b. C>T
c. C>G
d. C=T
14. Since the first nucleotides of a strand cannot be linked in a newly synthesized strand in
DNA replication, ____ is required.
a. a DNA primer
b. DNA polymerase
c. Ligase
d. an RNA primer
e. Helicase
15. Okazaki fragments are used to elongate…
a. The leading strand toward the replication fork
b. The lagging strand toward the replication fork
c. Both strands in both directions
d. The leading strand away from the replication fork
e. The lagging strand away from the replication fork
16. Each unit of a nucleic acid (consists of a sugar, attached phosphate group, and a base) is
a…
a. Nucleolus
b. Nucleotide
c. Nucleosome
d. Histone
17. Which statement about the elongation of the lagging strand during DNA replication is
correct?
a. It is synthesized in a 3’-----> 5’ direction
b. It progresses (grows) toward the replication fork
c. It requires a short RNA primer to proceed
d. It is synthesized continuously
18. T or F. The two sides of the double helix structure of DNA are held together with weak
hydrogen bonds.
a. True
b. False
19. Which strand grows continuously toward the replication fork?
a. Lagging strand
b. DNA strand
c. RNA strand
d. Leading strand
20. Nucleotides are added to the ____ end of an existing nucleotide.
a. 3’
b. 5’
21. Which of the following can be found at the end of DNA in Eukaryotes?
a. Telomeres
b. Topoisomerase
c. Helicase
d. Primase
22. Dense packing of the heterochromatin makes it difficult for the cell to do what?
a. The DNA will no longer be able to replicate
b. This dense packing happens only in prokaryotes, so it makes it difficult for the
cell to keep DNA inside the nucleolus
c. To express genetic information coded in regions
d. Elongate telomeres
Congratulations on making it through the practice quiz! I hope you did well ☺ If you have any
questions at all on solutions or concepts, just come visit me in SI! My hours are attached at the
top of the page. Just make sure to have at least attempted the problems beforehand.
Works Cited
"Meosis Practice Problems." ​1​. N.p., n.d. Web. 22 Mar. 2017.
"​Understanding Meiosis." ​Varsity Tutors​. N.p., n.d. Web. 20 Mar. 2017.