DHX Heat Exchanger
A new solution to heat transfer
Sterile, efficient and modular
The Thermo Scientific™ DHX™ Heat Exchanger is a modular system that
employs a plate-and-frame concept, using a single-use BioProcess Container
(BPC) as the sterile fluid path. The BPCs fit tightly between five dimpled,
stainless-steel plates efficiently transferring heat in a counter-current
flow path. The system provides efficient, sterile heat transfer that easily
integrates into any new or existing process.
Key features and benefits
Applications
• Completely isolated flow paths for process and
heat transfer fluid
Upstream
• Media hold
• Counter-current, serpentine flow patterns
• Mixing and fermentation
• Dimpled jacketing on the plates provides turbulent flow
• Cell separation/protein harvest
• BPCs fill in place with no operator interaction
• Harvest cooling
• Modular design and small overall footprint allows
for changing process needs
• Harvest hold
• Reduced infrastructure requirements
• Reduced processing time
• Improved product consistency
Downstream
• Harvest hold
• Buffers
• Protein purification
• Bulk drug substance
3
Technical specifications
DHX BPC assembly and plate system
Sterile fluid path for process fluid
Each single-use DHX BPC fits tightly between the stainless-steel
plate assembly. In a completely isolated flow path, the process
fluid flows through the BPCs counter-currently to the heating/
cooling fluid within the plates. Once the BPCs are loaded in
place, no further operator interaction is required.
DHX BPCs
DHX bioprocess equipment: plate system
General specifications
General specifications
Material of construction
Low-density polyethylene
ASI™ 26/77 film
Interconnecting tubing
C-Flex
Connections
ReadyMate™ DAC 500 as
standard; custom tubing
and connections upon
request
Flow rate capacity
Up to 15 L/min
Pressure/temperature rating
(Installed in DHX plates)
20 psig at 122°F (50°C)
BPC ordering information
Cat. No.
One BPC-26/77 film
(DAC connections on outlet ports)
DX00006-I
Two BPC assembly-26/77 film
(DAC connections on outlet ports)
DX00007-I
Three BPC assembly-26/77 film
(DAC connections on outlet ports)
DX00008-I
Four BPC assembly-26/77 film
(DAC connections on outlet ports)
DX00009-I
One BPC-26/77 film
(DAC connections and drain tubing)
DX00010-I
Two BPC assembly-26/77 film
(DAC connections and drain tubing)
DX00011-I
Three BPC assembly-26/77 film
(DAC connections and drain tubing)
DX00012-I
Four BPC assembly-26/77 film
(DAC connections and drain tubing)
DX00013-I
4
Material of construction
316L stainless-steel
Effective heat transfer area
Up to 27 sq. ft.
Overall dimensions (WxDxH)
51 x 74 x 69 cm
(20 x 29 x 27 in)
Number of plates/BPCs
5 plates/up to 4 BPCs
Dry weight
150 kg (331 lbs)
Full weight (includes 4 BPCs)
190 kg (419 lbs)
Pressure/temperature rating
FV/140 psig at 150°F
Pressure vessel code
ASME U-1
Connections
1/2” compression
Equipment ordering information
Cat. No.
DHX stainless steel unit
DHX1001
Please contact your Thermo Fisher BioProduction sales
representative for more information regarding customizations.
5
How it works
Tabs secure
Efficient heat transfer
Single-use solution for heat transfer
The BPC and the plates each have a
matching serpentine pattern. The heat
transfer fluid flows through the plate
system while the BPCs provide the
sterile fluid path for the process fluid,
each flowing counter-currently to the
other. The temperature differential of
the heat transfer fluid provides efficient
heat transfer to the process fluid.
BPCs in place
Hinge bolts secure
Process fluid
High point
BPC tubing
vent valves
connections
Safety
lever
Plate system
hose connections
Heat transfer fluid
BPC and plate system
6
plates in closed position
Heat transfer efficiency
Typical single-pass application
DHX cooling efficiency - from 37°C (single pass)
• Process fluid: Water at 37°C
DHX heating efficiency - from ambient
temperature (single pass)
• Process fluid: water at 20°C
• Heat transfer fluid: 30% propylene glycol at 2°C
• Heat transfer fluid: 30% propylene glycol at 42°C
• Heat transfer flow rate: 15 L/min
• Heat transfer flow rate: 15 L/min
• Number of BPCs: 4
• Number of BPCs: 4
35
30
25
ΔT (oC)
ΔTo (°C)
ΔT ( C)
ΔT (oC)
20
ΔT (°C)
ΔT (oC)
15
10
5
0
0
2
4
6
8
10
12
14
0
Flow Rate (LPM)
2
Flow
rate(LPM)
(L/min)
Flowrate
DHX
EFFICIENCES
DHX COOLING
COOLING
EFFICIENCES
LPM
LPM
LPM 10
10L/min
LPM
11L/min
33 L/min
55 L/min
40
40
3 LPM
5 LPM
10 LPM
11L/min
LPM
45
40
11 LPM
LPM
33 LPM
LPM
TEMP (oC)
TEMP
(oC)
55 LPM
TEMP
(oC)
Temp
LPM
TEMP
(oC)
10
10 LPM
LPM
20
20
Temp 15
15
(°C)
15
15 LPM
LPM
10
10
14
33L/min
LPM
15 LPM
55 L/min
LPM 10
10L/min
LPM 15
15 L/min
LPM
30
1 LPM
1 LPM
3 LPM
3 LPM
5 LPM
5 LPM
10 LPM
10 LPM
15 LPM
15 LPM
35
25
20
30
15
25
10
55
00
12
35
40
25
25
(°C)
10
DHX HEATING EFFICIENCIES
DHX COOLING
EFFICIENCES
1 LPM
3 LPM
5 LPM
10 LPM
15 L/min
LPM
15
15 LPM
30
30
TEMP ( C)
8
Represents the ΔT of process fluid (with a variable flow rate) as a
result of a constant 15 L/min flow rate of the heating fluid.
35
35
TEMP
(oC)
TEMP
TEMP(oC)
(ooC)
6
Flow Rate
(LPM)
Flow
rate
(L/min)
Flowrate
(LPM)
Represents the ΔT of process fluid (with a variable flow rate) as a
result of a constant 15 L/min flow rate of the cooling fluid.
1 LPM
4
00
55
10
10
Time
15
15
TIME
(min)
TIME
TIME(min)
(min)
(min)
TIME
(min)
20
20
Cooling efficiency measured by temperature vs. time
25
25
30
30
5
20
00
0
5
5
10
10
15
20
15(min)
20
TIME
TIME
(min)
TIME
(min)
Time
(min)
TIME
(min)
25
25
30
30
Heating efficiency measured by temperature vs. time
7
Integrated solutions for bioproduction
Liquid- and dry-format media
We offer both custom manufacturing
and a full range of chemically
defined performance media
and supplement products
Single-Use Mixers (S.U.M.s)
A variety of options up to
5,000 L for both upstream
and downstream applications
BioProcess Containers (BPCs)
A variety of configurations up
to 2,000 L for liquid harvest,
storage, and transportation
Sera
Our sera are the
industry standards for
consistent quality and
reliability
Single-Use
Bioreactors (S.U.B.s)
50–2,000 L bioreactors
capable of integrating with an
existing control system
Buffers and process liquids
Custom and standard buffers
and process liquids, including
Gibco™ Water for Injection
(WFI)–quality water
Integrity testing systems
A true point-of-use integrity testing system
to confirm the integrity of BPCs before use
Find out more at thermofisher.com/sut
Logan, Utah 84321
United States of America
+(1) 435-792-8500
Cramlington NE23 1WA
United Kingdom
+44 (0) 1670-734093
Millersburg, Pennsylvania 17061
United States of America
+(1) 717-692-2104
Matamoros, Tamaulipas 01152
Mexico
+011 (52) 868-8109700
© 2016 Thermo Fisher Scientific Inc. All rights reserved. All trademarks are the property of Thermo Fisher Scientific and its
subsidiaries unless otherwise specified. ReadyMate is a trademark of GE Healthcare Bio-Sciences AB. COL01365 0716