Welcome and Opening of the Workshop
Low-grade Inflammation
A High grade Challenge
Biomarkers and Modulation by Dietary Strategies
15 September 2013, Granada, Spain
Prof. Diána Bánáti
Executive and Scientific Director, ILSI Europe
1
ILSI Europe’s mission
Building a bridge between
science and today’s public health challenges
SCIENCE-DRIVEN organisation
Addressing COMPLEX scientific issues
Thanks to renowned EXPERTS and scientists
With COMPLEMENTARY experiences
2
Driven by Science
• Science-driven approach
• Portfolio and new activities reviewed by SAC and BOD
• Stringent scientific review of
• Scientific outputs
• Peer-reviewed articles in high impact factor journals
• Workshops and symposia with best scientists in the fields
• ILSI Europe sessions at key conferences
• At least 50% academics in EGs, SAC and BOD
• Close collaboration with key organisations
(e.g. WHO, FAO, EC, national authorities, etc)
• Wide network
•300
publications
•More than
12,542 citations
•h-index 56
3
3
Publications
> 300 peer-reviewed publications
Articles in peerreviewed journals
Black and White
reports
Concise
Monographs
www.ilsi.eu/Publications
4
Tripartite Approach
Applying state-of-the-art science to topics of common
concern, the collaboration between our experts provides
balanced, practical and high quality contributions
to public health science.
Clinicians
Epidemiologists
Toxicologists
Nutritionists
Public
Health
Food Safety
Research &
Development
EC
Consumer
Science
Regulatory
Affairs
National
Authorities
5
Highly renowned experts
2
• Collaborating
with 270 experts
from
26 countries
through 32 expert
groups
• Active network
of 500 scientists
2
2
4
7
57
1
53
22
20
1
28
26
14
Americas: 14
Asia: 6
Africa: 3
Middle East: 1
2
4
3
6
The ILSI family: a worldwide network
14 branches, 3 entities
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ILSI Europe Membership in 2013
62 Members
Abbott Nutrition
Ajinomoto Europe
Arla Foods
Barilla G. & R. Fratelli
BASF
Bayer S.A.S.
Bionov
Bunge Europe
Campbell Soup Company
Cargill
Coca-Cola Europe
Cosucra Groupe Warcoing
Danone
Dicofarm
Dow Europe
DSM
DuPont de Nemours
Eurofins
Firmenich
General Mills
Givaudan International
H J Heinz
Ingredion
Institut Mérieux
International Nutrition Company
Kao Corporation
Kellogg Europe
Kikkoman Foods Europe
Luigi Lavazza
Mars
McDonald's Europe
McNeil Nutritionals
Mead Johnson Nutrition
Merck Consumer Healthcare
Mondelēz International
Monsanto Europe
Nestlé
Newtricious
Nexira
PepsiCo International
Pfizer Consumer Healthcare
Pierre Fabre Dermo Cosmétique
Premier Foods
Procter & Gamble
Puratos Group
Red Bull
Roquette Group
Royal FrieslandCampina
Rudolf Wild
Sanofi-Aventis R&D
Schwabegroup
Sensus
Soremartec Italia –
Ferrero Group
Südzucker/BENEO Group
Swiss Quality Testing Services
Syngenta Crop Protection
Tate & Lyle Ingredients
Tereos-Syral
Tetra Pak Research
Ülker Bisküvi
Unilever
Yakult Europe
8
ILSI Europe
Structure
21 Task Forces
32 Expert Groups
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Task Force Portfolio
3 pillars, 21 task forces, 32 expert groups
Food Safety
• Addition of Nutrients to
Food
• Risk Assessment of
Foods*
• Emerging Microbiological
Issues
• Environment and Health
• Food Intake Methodology
• Functional Foods
• Novel Foods and
Nanotechnology
• Packaging Materials
• Process-related
Compounds and Natural
Toxins
• Risk Analysis in Food
Microbiology
• Threshold of Toxicological
Concern
Nutrition
• Dietary Carbohydrates
• Eating Behaviour and
Energy Balance
• Food Allergy
• Metabolic Imprinting
• Nutrient Requirements
• Nutrition and Immunity
• Nutrition and Mental
Performance
• Obesity and Diabetes
• Prebiotics
• Probiotics
• Public Health*
Societal aspects
Consumer Science
* These 2 Task Forces have not started yet
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Task Forces
Role
• Working bodies that initiate, undertake, develop and
manage all projects
• They decide the topics to be addressed
Composition
• Mainly composed of industry member representatives
• Academic co-chair
Process
• Expert groups, workshops, conferences, projects
funded by the European Commission
• Results primarily published in peer-reviewed journals
11
Events
3 workshops, 4 sessions in 2013
ILSI Europe Annual Symposium
26-27 March. 2013
@ Experimental
Biology 2013
(Boston, USA)
23 April 2013
Dosimetry brainstorming
16 Oct. 2013
@ EUROTOX
1-4 Sept. 2013
@ IAFP European Symposium
16 May 2013
@ ICN 2013
15-20 Sept. 2013
Low-grade inflammation WS
15 Sept. 2013
12
Events
Europe @ ICN 2013
3 workshops, 4ILSI
sessions
in 2013
@ Experimental
Biology 2013
(Boston, USA)
23 April 2013
• Session 'Biomarkers
of Annual
response
to
ILSI Europe
Symposium
26-27 March. 2013
nutrition interventions'.
• Oral presentation 'Towards nutrition
Dosimetry brainstorming
guidelines for maternal
and infant
16 Oct. 2013
nutrition to influence long-term health of
the offspring‘
• Several posters
@ EUROTOX
1-4 Sept. 2013
@ ICN 2013
15-20 Sept. 2013
In collaboration with 5 other ILSI branches:
• Session 'Food Allergy‘,
@ IAFP European
Symposium
• Session 'Energy Balance
and Active
16 May 2013
Living‘,
• Session 'Micronutrient Fortification Science and Strategies for Public Health
Improvement
in Asia’,
Low-grade
inflammation
WS
• Booth
#47.2013
15 Sept.
13
Current EC Projects
COSMOS (2007-2013): Partner
Integrated In Silico Models for the Prediction of Human
Repeated Dose Toxicity of COSMetics to Optimise
Safety
DIETS 2 (2010-2013): Partner
Dieticians Ensuring Education, Teaching and
Professional Quality – WP E-learning
TDS Exposure (2012-2016): Partner
Total Diet Studies – WP Dissemination
NutriTech (2012-2016): WP Leader
Application of New Technologies and Methods in
Nutrition Research - WP on harmonisation,
dissemination and stakeholder interaction
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Current EC Projects
EURO-DISH (2013-2016): Partner
Study on the Need for Food and Health Research
Infrastructures in Europe - WP on Methodological
Support
iFAAM (2013-2017): Partner
Integrated Approaches to Food Allergens and Allergy
Risk Management - WP Dissemination
PATHWAY 27 (2013-2018): WP Leader
Pivotal Assessment of the Effects of Bioactives on the
Health and Wellbeing, from Human Genome to Food
Industry- WP on guidelines for claims substantiation
EFFORT (2013-2018): Partner
Ecology of Drug Resistant Bacteria and Transfer of
Antimicrobial Resistance Throughout the Food Chain 15
Past EC Projects
EURRECA (2007-2011): Coordinator
European recommendations Aligned, www.eurreca.org
BRAFO (2007-2010): Coordinator
Benefit and Risk Analysis for Foods, www.brao.eu
PASSCLAIM (2001-2005): Coordinator
Process for the Assessment of Scientific Support for
Claims on Foods
FOSIE (2000-2003): Coordinator
Food Safety in Europe – Risk Assessment of Chemicals
in Food
FUFOSE (1995-1997): Coordinator
Functional Food Science in Europe
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New Activity & Budget document
Coming soon
www.ilsi.eu
17
2013 Obesity and Diabetes Task Force
Members
Dr Mirian Lansink – Chair
Dr Sophie Vinoy – Vice-chair
Danone
Mondelēz International
NL
FR
Dr Christian Baz
Ms Ellie Hadjilucas
Dr Sampo Lahtinen
Prof. Anne Marie Minihane*
Dr Satya Jonnalagadda
Dr Luc Sterkman
Ajinomoto Europe
Coca-Cola Europe
DuPont Nutrition and Health
University of East Anglia
General Mills
Newtricious
CH
UK
FI
UK
US
NL
Scientific Project Manager (SPM)
Ms Athanasia Baka
* Scientific Advisor
ILSI Europe
BE
2013 Metabolic Imprinting Task Force
Members
​Dr Ricardo Rueda ─ Chair
​Prof Stewart Forsyth ─ Vice-Chair
Abbott Nutrition​
​DSM - Martek Division
ES​
​UK
​
​
​
​Dr Eurídice Castañeda Gutiérrez
Dr Dianne Delsing
​Dr Marieke Schoemaker
​Dr Julie Davey Dalsgaard Lund
​Dr Eline van der Beek
​Nestlé
Royal FrieslandCampina
​Mead Johnson Nutrition
​Arla Food Ingredients
​Danone
​CH
NL
​NL
​DK
​SG
​
Scientific Project Manager (SPM)
Ms Marie Latulippe
ILSI Europe
BE
Collaborating ILSI branches
20
ILSI Brazil
ILSI Brazil
Functional Foods Task Force
Responsible for developing activities related to
Biomarkers & Inflammation
Main activities where this issue has been addressed:
• Workshop: Carbohydrates, Microbiome and Health
• Workshop on December 2011
• Publication on January 2013
• Symposia on Biomarkers and Health
• June 2012 (invited international
speaker: Dr. John Milner)
• June 2013 (invited international
speaker: Dr. Seppo Salminen)
TM
ILSI North America
Linoleic Acid (LA) and Markers of
Inflammation: what RCTs tell us
• In July of 2012 the first systematic review of the clinical
literature addressing the hypothesis that dietary Linoleic
Acid promotes inflammation was published.
J Acad Nutr Diet, vol. 112 (July 2012)
• Key Finding: The data from 15 clinical trials provided
NO support for the theory that diet LA promotes
inflammation in healthy humans.
• For example, circulating C-reactive protein (CRP) is NOT
significantly altered by large changes in Linoleic Acid intake...
*DRI for LA is 11-12 g/d for women; 14-17 g/d for men.
ILSI South East Asia Region
ILSI Southeast Asia Region
• Presentations at the ‘Conference on Healthy Aging in Asia’
– Singapore, March 2013
– ‘Inflammaging’ - age-related systemic inflammation
– Presence of obesity exacerbating chronic inflammation
– negative effect on healthy aging
• Identified as a key focus area for future research into
healthy aging in Southeast Asia
TM
www.ilsi.eu