Applied Pharmacokinetics and
Pharmacodynamics Workshop 6-7th
July 2017
University of Hertfordshire, UK
6 – 7 July 2017
Preparation to be completed by delegates prior to the workshop
DAY 1: THURSDAY 6 JULY 2017
PK modelling
The PK modelling will take place in our computer suite in the New Science Building.
In preparation for this simulation students will need to research the following PK
parameters of an orally bioavailable drug of your choice or choose a drug from
Table 1.
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Clinical dosing regimen (mg/70kg)
Oral bioavailability (%)
Urinary excretion (%)
Bound in plasma (%)
Clearance (ml/min/70kg)
Volume of distribution (L/70kg)
Half life (hours)
Therapeutic effective concentration range (ug/ml)
Toxic concentration range (ug/ml)
Oral Absorption rate constant (Kab). Usually drugs follow 1st order rate
constants (which is Kab of 0.5. Therefore use 0.5 unless you discover a
different value.
DAY 2: FRIDAY 7 JULY 2017
Clinical Scenario
The clinical scenario simulation will take place in the Simulation Centre of the New
Science Building and will require some pre-studying of the pharmacology of the
drugs which you may encounter in treating your patient. Look up the drug in any
textbook and BNF and be prepared with the following information about your drug:
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6.
What is the drug generally used for?
What are the important common adverse reactions to this drug?
Are there any major drug interactions associated with the drug?
If it is a Trade name, what is the generic name of the drug?
If not a ‘drug’, what is the clinical relevance of the product?
What is the mechanism of action of this drug?
On the day, you will be divided into groups of 3-4 members; 1 will act as monitor to
record the details of the scenario, and the others will act as decision makers. All
group members need to be familiar with the list of drugs (provided in table), and
may use the BNF throughout the scenario.
In clinical simulation session:
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Each group will be attending a doctors’ ‘Ward Round’ in the ‘hospital’ where
you will be presented with a patient (mannequin) and their clinical condition.
All Students will be expected to contribute to the ‘ward round’ scenario.
Be prepared to provide information about your drugs during the scenario
when the patient is being treated or discussed.
Be prepared to know when to use your particular drugs, and respond to the
changing scenario.
All scenarios are followed with a de-brief by a clinical pharmacologist. It is
advised that you make detailed notes since the Reflective Account will
require you to write a pharmacological breakdown of one of the scenarios.
Acetylcysteine
Atenolol
Cefotaxime
Clindamycin
Desferrioxamine
Fersamal syrup
Naproxen
Trimethoprim
Adrenaline/epinephrine
Atropine
Chloramphenicol
Cranberry juice
Diazepam
Medised
Penicillin/benzylpenicillin
Warfarin
Amiodarone
Calpol
Citalopram
Co-amilofruse
Digoxin
Metronidazole
Prednisolone
Table 1. Pharmacokinetic and Pharmacodynamic parameters for selected drugs.
http://www.columbia.edu/itc/gsas/g9600/2004/GrazianoReadings/Drugabs.pdf