This is a very important document for everyone... EVERYONE WHO HAS BEEN DIAGNOSED WITH BREAST CANCER EVERYONE WHO IS AFFECTED BY BREAST CANCER EVERYONE WHO HAS LOST SOMEONE TO BREAST CANCER EVERYONE WHO RAISES FUNDS TO FIGHT BREAST CANCER EVERYONE WHO CAMPAIGNS FOR IMPROVEMENTS IN TREATMENTS AND SERVICES EVERYONE WHO FEARS BREAST CANCER this is not a report about financial gain but HUMAN gain EVERYONE WHO CARES FOR FELLOW HUMAN BEINGS EVERYONE WHO BELIEVES IN HUMAN ENDEAVOUR EVERYONE WHO SHARES THE VISION OF A FUTURE FREE FROM THE FEAR OF BREAST CANCER … everyone and that’s it is about the progress IN the fight against breast cancer in the uk the annual report for breakthrough breast cancer 2007/2008 www.breakthrough.org.uk Since becoming Patron of Breakthrough Breast Cancer, I have taken a keen interest in the charity’s progress and I continue to be immensely impressed by what Breakthrough has achieved in a relatively short amount of time. In 1999, I opened Breakthrough’s dedicated breast cancer research centre. At that time, the Breakthrough Toby Robins Breast Cancer Research Centre in the Mary-Jean Mitchell Green Building at The Institute of Cancer Research was a new idea and was the first of its kind in the UK. Its advancement of our understanding of breast cancer since then has demonstrated the value of such a centre. It was therefore a privilege, eight years on, to be involved in another milestone for Breakthrough when I recently opened the Breakthrough Breast Cancer Research Unit at the University of Edinburgh. It was clear that the work being carried out there will make an enormous difference to so many patients. I was also fortunate to meet some of Breakthrough’s supporters. I am always both moved and impressed by these advocates for Breakthrough who are so resolute in their determination to do all that they can to help Breakthrough achieve its vision of a future free from the fear of breast cancer. During this year I was also encouraged to hear that Breakthrough’s complementary therapy study to investigate whether acupuncture may help women with fatigue, a common side effect of chemotherapy treatment, had begun, and I look forward to learning more about this trial as it progresses. But it is not just Breakthrough’s research that is significant. Each day Breakthrough is working to increase awareness of breast cancer and ensure improved outcomes for the, sadly, increasing number of women – and men – who are diagnosed each year. I wish everybody continued success in progressing all areas of their vital work in the year ahead and look forward to hearing of further advances made by the charity. why? Because breast cancer is the most common cancer in the uk Every year in the UK nearly 46,000 women and 300 men are diagnosed with breast cancer Every year over 12,000 women die from breast cancer in the UK THE INCIDENCE OF BREAST CANCER IN THE UK HAS BEEN INCREASING EACH YEAR The lives of hundreds of thousands of people in the UK are affected by breast cancer Breakthrough Breast Cancer is the leading charity committed to fighting breast cancer through research, campaigning and education Our vision is a future free from the fear of breast cancer. Our mission is to improve and save lives of people affected by breast cancer through well-informed, well-resourced and innovative research, campaigning and education. We will place supporters at the heart of Breakthrough: the way we think, the way we work and the way we change lives to achieve a shared vision. Report of the Board of Trustees | 1 2 | Report of the Board of Trustees For a future free from the fear of breast cancer THROUGH RESEARCH THROUGH CAMPAIGNING THROUGH EDUCATION Chairman and Chief Executive’s introduction It is therefore fitting that in a year when so much has been achieved in our research work that the Director of the Our vision is a future free from the fear of breast cancer. As Breakthrough Research Centre, Professor Alan Ashworth, we continue to work towards making that vision a reality we has been elected a Fellow of the Royal Society, in recognition remain confident, ambitious and innovative. We know that of his outstanding contribution to cancer research. This much has been achieved already in the short history of our is a magnificent tribute, both to him personally and to charity, but that much more still needs to be done. That is why Breakthrough, and is testament to the value and importance we remain driven in our desire for exceptional results – in our we ascribe to cutting-edge scientific research. research, campaigning and education work. We are also delighted that Breakthrough trustee and Chair Breakthrough has accomplished much during this year. of our Science Committee Professor Sir Martin Evans was From the opening of a new research unit in Edinburgh to our awarded the 2007 Nobel Prize for Medicine, in recognition collaborative work with other charities, Breakthrough has of his groundbreaking work in developing new techniques been at the forefront of ensuring that breast cancer receives to target and understand how genes function. the attention it deserves. There are now a remarkable five clinical trials underway due to the research carried out at the But it is not just in the area of research that we are successful. Breakthrough Toby Robins Breast Cancer Research Centre Our influencing work ensures that breast cancer remains housed in the Mary-Jean Mitchell Green Building at The high on the political agenda. In November 2007, business Institute of Cancer Research. There, nine teams tackle breast guru and NHS trouble-shooter Sir Gerry Robinson, along with cancer through a broad programme of research. Inspired Professor Mike Richards, National Cancer Director, attended by the centre’s leadership, we now have a collaborating a special event in Whitehall to celebrate the 1,000th member research unit established in Edinburgh, with two further sites joining Breakthrough’s Campaigns & Advocacy Network. It is due to open in Manchester and at King’s College London this amazing body of campaigners that informs and enables during 2008/09. Each unit is located alongside a nationally our influencing of NHS provision at local and national levels. recognised centre of clinical excellence, replicating the location A key development in the year was the Department of Health of the Breakthrough Research Centre alongside the world- updating the National Cancer Plan with a Cancer Reform renowned Royal Marsden Hospital, and our expectation is Strategy. Breakthrough was invited to chair the Breast Cancer that work carried out at these units will help to speed up the Working Group and the Strategy was published in December progress of our breast cancer research. 2007. Since then we have been seeking to ensure that its recommendations are implemented across England, while Our ambitious longterm study into the causes of breast cancer, also awaiting similar plans for the other nations. the Breakthrough Generations Study, reached an important milestone this year as our scientists began preparing to analyse In order to establish a strategic presence in Scotland, we set the data from the 97,000 women now enrolled. We expect our up a team based in Edinburgh. This will allow Breakthrough target of 100,000 women to be met by the end of 2008. to extend its campaigning and education work throughout Report of the Board of Trustees | 3 Scotland and maximise the opportunities from the research under the inspirational leadership of Mervyn Davies, ensured unit based in Edinburgh. that the Breakthrough Generations Appeal reached its target of £12 million ahead of time. Meanwhile, throughout the year We are proud of the extent to which we engage with different our Group members and their dedicated volunteers raised organisations and the work that we do in partnership with funds and awareness throughout the UK – from Aberdeen in others, such as Breast Cancer Care, Breast Cancer Campaign Scotland to Jersey in the Channel Islands – while our £1,000 and the NHS Centre for Involvement, as well as the work Challengers contributed almost £1 million over the year. Thank our scientists do in collaborating with others around the you all for enabling Breakthrough’s achievements. world. We believe that this type of combined effort promises the best outcomes for people with breast cancer, both in Every member of Breakthrough’s staff is a vital contributor terms of research and by strengthening patient and service to our success and we remain impressed by the dedication user voices in breast cancer. and commitment they demonstrate towards the charity. Sharing in our passion to make a difference is seen by levels In 2007/08 our breast awareness TLC – Touch Look Check of motivation and satisfaction ahead of most charities, as promotion of the signs and symptoms of breast cancer recorded by our annual staff opinion survey. reached more women than ever before, particularly through the support of Marks & Spencer and Avon Cosmetics. Breakthrough has never shirked challenges and the last year We also completed the first stage of a structured breast has demonstrated that we are more than able to rise to them. awareness project and look forward to building a firm body We know that more hurdles lie ahead in the year to come, as of evidence-based information about what interventions can we face a downturn in the economic climate while also aiming influence the behaviour of women at risk of breast cancer. to reach the target of £18 million that we have set ourselves to fund our work in 2008/09. But we are confident that we Many individuals play their part for Breakthrough and to each will continue to meet the challenges that arise and to make of them we extend deep and heartfelt thanks. Many inspire progress on behalf of all those affected by breast cancer. others to follow their lead, not least Nina Barough, Founder of Walk the Walk, with whom we celebrated ten years of the Stephanie Monk Jeremy Hughes MoonWalk; while the Breakthrough Generations Appeal Board, Chairman Chief Executive Our Three-Year Strategic Plan 2007–2010 Everyone who is, or has been, involved with Breakthrough consultation, both within and outside the charity, and was Breast Cancer should feel proud of what the charity has designed to guide us through this three-year period with a achieved since our beginning in 1991. In the last few years, clear, purposeful and renewed focus on what we want to in particular, the pace of development within the organisation achieve and how we want to achieve it. has been extensive. From the launch of the groundbreaking Breakthrough Generations Study to our increasing effectiveness The Strategic Plan does not aim to capture everything we in improving breast cancer services, our impact has been, do, but instead seeks to ensure that we both understand the and remains, formidable. All these successes have helped to challenges we face and give due attention to new initiatives. establish Breakthrough as the leading breast cancer charity Our three charitable objectives – research, campaigning and in the United Kingdom, offering hope to thousands of people education – are at the core of all our work. Our emphasis affected by breast cancer. on longterm planning will ensure that we maximise our effectiveness in these three vital areas, while securing a strong At this time of rapid progress in breast cancer research and and stable financial and organisational base from which to changes in the NHS, as well as of huge pressures within the facilitate this work. economy as a whole, we need to ensure that our purpose, energy and commitment are focused appropriately, in order On the following pages we report on the results of the first that we can continue to build on our successes. year of the plan. In 2007 therefore we set out our three-year Strategic Plan. This was a culmination of in-depth research, analysis and 4 | Report of the Board of Trustees Research Campaigning Education Report of the Board of Trustees | 5 The Molecular Pathology Laboratory is just one of Breakthrough’s many research teams that is taking forward our pioneering work into the treatment of breast cancer. 6 | Report of the Board of Trustees Research To establish a cohesive UK research network of scientific excellence that increases understanding of breast cancer and will measurably translate into improvements in prevention, quality of life, diagnosis and treatment. What we’ve achieved As part of our work to make our vision of a future free from the fear of breast cancer a reality, we have been developing the Researching new Breakthrough Research Units located at the Universities In 2007/08, Breakthrough committed £7 million to research of Edinburgh, Manchester and King’s College London. Each as we continue to try to find new ways to treat, diagnose research unit will focus on a specific aspect of breast cancer. and prevent breast cancer, and improve quality of life for These new units represent a major extension in our breast those affected. The majority of this funding was allocated cancer research work and it is hoped that the work carried to the Breakthrough Research Centre in London, for the out in the units will accelerate progress towards our vision. costs of our research scientists and the tools and equipment The new research units embrace Breakthrough’s philosophy that are vital to their work. towards research which has already proved so successful for the Breakthrough Research Centre in London – bringing The Breakthrough Research Centre had several outstanding scientists and clinicians together in a multidisciplinary achievements during the last year. In May 2008, Professor environment in order to rapidly translate their research into Alan Ashworth, Director of the Breakthrough Research Centre benefit for patients. since it opened in 1999, was elected a Fellow of the Royal Society – the UK’s highest scientific accolade – in recognition By the end of the year, there were over 200 research staff of his outstanding contribution to cancer research. In working in Breakthrough's centre, units and on associated early 2008, Professor Ashworth’s scientific progress was projects, with approximately two-thirds of these staff directly emphasised through two groundbreaking discoveries, which funded by the charity. were published in the highly prestigious science journals Nature and Cancer Cell. In these publications Professor Ashworth The Breakthrough Research Unit at the University of Edinburgh and his colleagues described how certain types of breast opened in June 2008 and is fully recruited and operational. cancer become resistant to treatment, in one case identifying We were delighted that HRH The Prince of Wales was a completely new genetic mechanism leading to resistance. able to open this unit. Based next to the Western General In the future, these findings could help ensure that patients Hospital’s Breast Cancer Clinic, the Edinburgh unit will focus receive treatments that are most effective for them. In the past on improving treatment for hormone-sensitive breast cancer, year alone, work from the research centre was published in the most common form of the disease. Women with this type 85 research papers. of tumour are usually treated with hormone therapies, such as The Royal Society is the world’s oldest scientific academy Alan Ashworth began his career at The Institute of Cancer in continuous existence and has been at the forefront of Research after graduating from Imperial College and gaining a enquiry and discovery since its foundation in 1660. The PhD in Biochemistry from University College London. In 1995 Fellowship of the Royal Society is composed of the most he was a member of the team that discovered the BRCA2 distinguished scientists of the day. Fellows are elected by gene – one of the genes linked to hereditary breast cancer. peer review for life and are entitled to use FRS after their In 1999, Professor Ashworth was appointed Director of the name. There are currently more than 60 Nobel Laureates Breakthrough Research Centre where he also heads the Gene among the Society’s approximately 1,400 Fellows and Function Team, which specialises in understanding more Foreign Members. about the genes involved in the development of breast cancer. Report of the Board of Trustees | 7 tamoxifen, but not everyone benefits from these treatments Collaborating and many women experience the problem that their treatment Integral to our research strategy for the coming years is the stops working because of drug resistance. The unit will bring promotion of interaction and collaboration between scientists together some of the best Scottish-based scientists and doctors at Breakthrough-funded locations. To advance this aim, to develop a centre of excellence for breast cancer research. we hosted a highly successful workshop in Cambridge in September 2007 to bring together scientists from the research During 2007/08 over 15,000 women joined the Breakthrough centre and the new research units to discuss their research Generations Study, which will advance our understanding of and explore new ideas. An evaluation of the event revealed the causes of breast cancer. 97,000 women have now elected that 100% of delegates rated the workshop as excellent, with to join the study, which means that our target of 100,000 75% stating that they had made contacts that could yield participants will soon be reached – nearly one year ahead of future collaborations. schedule. Expected to run for over 40 years, the study aims to pinpoint genetic, hormonal, lifestyle and environmental factors that increase an individual’s risk of breast cancer. Since 2004 we have been funding the Breast Cancer Clinical Outcome Measures study (BCCOM). This project collects high-quality data on breast cancer cases in order to compare Clinical trials current practices and link them to clinical outcomes. This In 2007/08, we launched two new clinical trials, each tackling important study has the potential to improve the effectiveness different aspects of breast cancer and its treatment. These of breast cancer treatments across the UK. We are delighted were the Triple Negative Trial and the ACU Fatigue Trial. that BCCOM will become an integral part of the UK’s National Cancer Intelligence Network, which was set up to maximise The Triple Negative Trial, funded in partnership with Cancer the use of information about cancer treatments to improve Research UK, will investigate a potential new treatment for quality and patient choice. women with ‘triple negative’ breast cancer. This particularly aggressive form of cancer is more common among younger Communicating women and those of African ethnicity, and patients do not In December 2007 Breakthrough scientists attended the benefit from hormone therapy or Herceptin, which have 30th San Antonio Breast Cancer Symposium, the largest proven to be effective for treating other types of breast cancer. international conference for clinical breast cancer research, The launch of this trial means that five clinical trials have where they gave a number of presentations. Professor Mitch now been initiated since the research centre opened in Dowsett, Head of the Translational Research Team at the 1999 – a significant achievement. Breakthrough Research Centre, received a highly prestigious award in recognition of the huge contribution he has made The ACU Fatigue Trial is the world’s largest and most over the past 20 years to improving both our understanding advanced clinical trial to investigate whether acupuncture and the treatment of hormone-sensitive breast cancer. may help women cope with fatigue – a major side effect Dr Susana Banerjee, a Clinical Fellow from the Molecular of breast cancer treatment. Endocrinology Laboratory, gave a presentation on her On 5 June 2008, the Breakthrough Research Unit, Edinburgh was officially opened by HRH The Prince of Wales. This is the first of Breakthrough’s three new research units to open. The other two units will be based at King's College London and in Manchester, and will open during 2009. Each unit will undertake research into a specific aspect of breast cancer, marking a significant expansion in breast cancer research. 8 | Report of the Board of Trustees groundbreaking work on angiogenesis. Breakthrough Future plans also exhibited at the Symposium for the first time. This We expect all three Breakthrough Research Units to be enabled us to communicate and promote our work on operational by the end of the financial year 2008/09. We will the international stage, helping to cement our reputation continue to support and encourage collaboration between as a funder of world-class research. scientists at the different sites. We will hold at least two workshops, focusing on a specific theme, where new ideas Our research website is designed for the scientific community, and approaches to tackle breast cancer can be generated. to enable us to inform other scientists of the work we are doing and to promote our pioneering research. In 2007/08, Dr Anthony Kong, the first doctor to be awarded funding we redeveloped the research website to include new clinical through our Breakthrough Clinical Researcher Programme, research and the work that will be carried out in the new started work in September 2008. The purpose of this research units. In this year we also created a new annual programme is to give outstanding and committed medical research publication Highlight. Designed for the scientific doctors the opportunity to carry out scientific research in community and those supporters with a particular interest addition to their clinical work in hospitals. Working within in our research, this publication gives a detailed analysis of the Oxford Radcliffe NHS Trust and the Weatherall Institute Breakthrough’s research and showcases some of the major of Molecular Medicine in Oxford, Dr Kong aims to develop successes that Breakthrough scientists have achieved. a new, more sensitive test to predict with greater accuracy whether a patient is likely to benefit from Herceptin. Every five years Breakthrough holds a rigorous review of its major ongoing research programmes to ensure that funding is being committed to research of the highest quality. The forthcoming year will see such quinquennial reviews taking place for the Breakthrough Research Centre and the Breakthrough Generations Study. Our Scientific Advisory Committee, composed of independent experts from around the world, will scrutinise the progress and future plans of the research centre, providing invaluable advice to Breakthrough on the future commitment of funding. The development of the three Breakthrough Research Units and the first appointment through our Clinical Researcher Programme represent a significant increase in our commitment to tackle breast cancer, building on the success of the Breakthrough Research Centre in London. The charity needs to have the appropriate tools to manage effectively an increasingly diverse portfolio of research; we are therefore introducing a new research grants management system. This system will help us to efficiently manage research information and all aspects of our grant application process. In some women, the female hormones oestrogen and progesterone can encourage the growth of breast cancer cells. This is known as hormone-sensitive breast cancer and is the most common form of the disease. Bringing together expert scientists and clinicians, the Breakthrough Research Unit in Edinburgh will be working to improve the treatments available for women with this type of breast cancer and to ensure that patients benefit from research as quickly as possible. Report of the Board of Trustees | 9 Breakthrough puts people affected by breast cancer at the heart of its campaigning, as we work towards improving services and treatments at both local and national levels. 10 | Report of the Board of Trustees Campaigning and Influencing To extend our influence and impact through evidence-based campaigns and policies so as to lead to real improvements in breast cancer services and treatments. What we’ve achieved (our campaign to reduce waiting times for referral to a specialist), Family History Campaign (to improve services Building relationships for women with a family history of breast cancer) and In order to keep Breakthrough and the issue of breast cancer Screening Saves Lives (our campaign to improve access high on the political agenda it is essential that we make and to breast screening services). maintain relationships with Members of Parliament across the political spectrum. In surveys conducted by an independent Breakthrough’s Chief Executive was invited to chair the Breast company, nfpSynergy, into recognition rates of charities within Cancer Working Group for the Department of Health and parliament and MPs’ opinions on the effectiveness of charities, we fed in to the discussions of the Group. The Group Breakthrough achieved exceptional figures. We remain the recommended the breast cancer related content of the leading organisation that MPs first think of when it comes Cancer Reform Strategy, which was launched in December to breast cancer and have significantly increased our profile 2007, and also produced Breast Cancer: A Vision for 2012. with MPs. In July 2008, 50% of MPs said they thought of Breakthrough first in relation to breast cancer; this is up from Campaigning nationally 30% in July 2007. Following a survey in March 2008, 70% In his first speech as Prime Minister at the Labour Party of MPs surveyed also thought that Breakthrough was an conference in September 2007, Gordon Brown announced effective campaigning organisation. These statistics are that the age range for automatic invites to NHS breast a reflection of the persistent political and lobbying activity screening was to be extended to all women aged 47–73 by undertaken by Breakthrough and our determination and 2012. This was also confirmed in the 2007 Cancer Reform rigour in following up political contacts and opportunities. Strategy. Breakthrough was delighted with this as we had consistently called for a review of the screening age limit. Breakthrough’s parliamentary work was also publicly acknowledged when we won the ePolitix Most Effective In May 2008, Breakthrough and the All Party Parliamentary Campaigning Charity Award for 2007. This award recognised Group on Breast Cancer held a successful parliamentary the considerable achievements brought about by several reception, along with the NHS Breast Screening Programme (NHSBSP), to mark the 20th anniversary of the Programme. of Breakthrough’s key campaigns, namely Left in the Dark In November 2007, Breakthrough held a reception to celebrate reaching 1,000 CAN members. Sir Gerry Robinson attended and encouraged CAN members to continue campaigning. He also presented commemorative plaques to a founding member, Jane Stephenson, and to Breakthrough’s 1,000th CAN member, Jane Hughes. Also present were MPs and the National Cancer Director, Professor Mike Richards, who paid tribute to the influence of CAN members in improving breast cancer services, treatments and research. Report of the Board of Trustees | 11 Over 60 parliamentarians, together with breast cancer advocates, that featured patient involvement and highlighted the Service research scientists and healthcare professionals, attended Pledge as an example of best practice. We also commissioned this reception. Breakthrough also used this event to highlight an interim evaluation by an external consultant. This showed that to parliamentarians the digital mammography strand of our the Service Pledge is an effective way of improving local breast Screening Saves Lives campaign, which complements the cancer services and patients’ experiences. emphasis in the Cancer Reform Strategy on early detection. Changing health policy Due to the extension of the NHS Breast Screening Programme, Breakthrough continued to influence significant areas of health and an ageing ‘baby boomer’ generation becoming eligible policy development throughout 2007/08. Highlights included for breast screening, screening invitations are expected work to ensure that the recommendations made in the Cancer to increase by more than 400,000 a year. Breakthrough Reform Strategy are implemented. successfully lobbied the Government to ensure that the Comprehensive Spending Review guaranteed sufficient Breakthrough also continued to influence health policy by funding to enable the NHSBSP to be able to respond to responding to over 40 consultations of significance to people the growth in demand for its services. Breakthrough was affected by breast cancer, in particular from the Department of pleased to hear the then Chief Secretary to the Treasury, Andy Health, the National Institute for Health and Clinical Excellence (NICE) and the Scottish Medicines Consortium. Burnham MP, confirm that funds would be made available for the implementation of the screening age extension. He also commended Breakthrough for raising this issue with him and We responded to Lord Darzi’s Next Stage Review of the NHS. his department. We emphasised the crucial importance of improved data on outcomes to drive quality improvements, support for research, Improving locally the role of specialist nurses, and the need for continuity of care Breakthrough has developed the Service Pledge for Breast if the move towards more care in the community continues. Cancer as a tool to enable patients and health professionals Breakthrough took every opportunity to ensure that the issues to work in partnership towards better local breast cancer of importance to people with breast cancer were fed into the services. It sets the standard that Breakthrough believes every hospital breast unit should meet and asks health professionals review and that members of Breakthrough’s Campaigns & Advocacy Network (CAN) had opportunities to attend the full to work towards meeting these standards, while consulting range of stakeholder events organised as part of the review. patients about what improvements matter most to them. Creating powerful partnerships with people affected by In 2007/08, Breakthrough successfully launched ten local breast cancer Service Pledges. These included a wide range of improvement Breakthrough CAN is made up of individuals and organisational goals, ranging from a post-surgery photo album (including members with personal experience of breast cancer or a pictures of women after lumpectomy, mastectomy or strong interest in breast cancer issues, who campaign for breast reconstruction) to a dedicated breast ward. The improvements in breast cancer services, treatment and Service Pledge has also been recognised externally, achieving research. Throughout 2007/08 Breakthrough continued to Runner-Up status in the Partnership category of the NHS develop ways of working in partnership with CAN members Centre for Involvement’s ‘Involvement to Impact’ Awards. to ensure our campaigning and influencing work is directly Along with the renowned health policy organisation the Picker informed by the views and priorities of people affected by Institute, Breakthrough jointly produced an information leaflet breast cancer. Patients and staff in the breast unit based at the Pilgrim In July 2008, a new breast unit opened at the hospital. The Hospital in Boston, Lincolnshire used to be housed in a contrast with the former premises could not be more marked. Portakabin. Conditions were far from ideal: space was There’s now plenty of space, a reception, toilets and a cramped, there was no reception or toilets and the lack of dedicated counselling room where the breast care nurses adequate facilities made it difficult for the nurses to speak can speak to patients in private. A former breast cancer to patients in private. A new unit was a long-held aspiration. patient, Annette Simpson, commented: ‘‘It’s like entering a Through the Service Pledge, Breakthrough worked with different world from the rest of the hospital. Walking through the hospital to carry out a patient survey and interviews, reception, I was greeted with a winning smile. The colours are providing important evidence in the case for the new unit. stunning and everything blends in – it’s a great experience.’’ 12 | Report of the Board of Trustees In November 2007, we reached a milestone when we recruited Future plans our 1,000th member. A celebratory reception was held at the As well as continuing to build on existing successful campaign Foreign and Commonwealth Office in London, attended by areas, Breakthrough will be developing two major new special guest Sir Gerry Robinson. We also used this reception campaigns over the next year, following consultation with to launch our Campaigns Handbook – all the tools you need CAN members and other stakeholders. Our new campaigns to grow your own successful campaign. This was developed will be on age equality and access to lymphoedema services. in partnership with experienced local campaigners in order to equip CAN members with the knowledge and practical Breakthrough plans to launch a further ten new Service tips required to maximise the impact of their local campaigns. Pledge sites over the next year, including ones in the North West and Scotland – areas where we have not The CAN Training Programme, comprising six courses been involved previously – representing our continued designed by and for CAN members, was successfully commitment to this successful project. delivered in London, Birmingham and York. Over 90% of CAN members who attended courses took part in Breakthrough’s work to influence significant areas of health campaigning activities within three months of attending policy will continue throughout 2008/09. The publication of the Cancer Reform Strategy (CRS) in December a CAN training course. 2007 represented an important milestone in improving In 2007/08, Breakthrough launched a new process to cancer services in England. Breakthrough will continue to involve CAN members in the selection of new campaigns influence the recommendations made in the CRS through and influencing priorities for the year ahead. This process, our involvement on bodies such as the National Cancer known as Influencing for Impact, involved CAN members Survivorship Initiative and the National Awareness and Early contributing to a longlist of all the issues where we could Detection Initiative, and also by ensuring that the new NICE have a positive influence on breast cancer services, treatments guidelines on early and advanced breast cancer fully reflect and research. CAN members, breast care nurses and other the needs of people affected by breast cancer. stakeholders were also involved in prioritising the issues. At the request of the Department of Health and the National Breakthrough’s reputation for good practice in involving our Cancer Director, Breakthrough was asked to lead on obtaining stakeholders has presented us with numerous opportunities, the views of people affected by breast cancer to feed into in particular being invited to run a workshop on ‘Building a the Government’s review of drug co-payments. We will Strategy for User-Involvement’ at the Long-Term Conditions continue to build on our innovative consultation work around Alliance AGM. We were able to influence the agenda for this complex and controversial issue, and to ensure that Patient and Public Involvement in the NHS through our role women with breast cancer have access to effective treatments on the NHS Centre for Involvement Strategic Advisory Board. based on their clinical needs. We also contributed to Natural Ground, a project led by the Association of Medical Research Charities that explores how With an increasing proportion of key decisions in healthcare patient advocates can help scientists to develop research being made locally, Breakthrough will continue to develop for greatest benefit. strategies to ensure its influence at a local level becomes as strong as its national influence. This will include a series of initiatives to further develop the Campaigns & Advocacy Network and ensure its potential for influencing at a local level is fully exploited. As part of Breakthrough’s increasing work in Scotland, a lobbying event with Scottish CAN members, key political contacts and health professionals will be held in Edinburgh in December 2008. We will be working to influence Better Cancer Care, which will map out the Scottish Government’s approach to cancer care. We will be identifying those issues of importance to people affected by breast cancer in Scotland. The newly developed team in Scotland will provide an opportunity to take this forward. Report of the Board of Trustees | 13 Our education work raises awareness of the signs and symptoms of breast cancer and encourages women to attend their breast screening appointments. 14 | Report of the Board of Trustees Education To reach specific groups of women at higher risk of breast cancer IN ORDER to influence their behaviour and so drive early diagnosis. What we’ve achieved that while many women claim to be aware of the signs and symptoms of breast cancer, few can name more than one – Piloting evidence-based health promotion a lump. The research also highlighted that many women are We know that the risk of breast cancer increases with a still unaware that they are at increased risk due to their age. woman’s age. We also know that early detection of breast cancer offers a woman the best chance of a successful The results of this research will form the evidence from which outcome. We believe that we can play a vital role in improving we will develop the pilot. When the pilot is complete, the early diagnosis in women aged 45 and over by increasing research will be re-run to assess the impact of our work. We breast awareness and attendance at the NHS Breast are grateful for a Department of Health grant that contributed Screening Programme. to this exploratory research. Unfortunately, uptake of screening in many areas is still Our research also indicated that there is much that needs well below the national target of 70%. In 2007/08 therefore to be done to increase awareness of the key signs and we began developing a health promotion pilot project in symptoms of breast cancer among primary care staff, as association with Camden Primary Care Trust. This evidence- well as in improving their understanding of the importance based pilot is targeting women aged 45–54 and aims to raise of early diagnosis via breast awareness and screening. The breast awareness and promote the importance of breast vital role that healthcare professionals play in communicating screening. Camden was chosen on the basis of a number this message to patients also needs to be amplified. of factors: only 55% of women turn up for their screening appointment when invited, screen-detected cancers are at a Reaching people with a simple message more advanced stage than in other parts of the country, and Throughout 2007/08 over 200 press, radio or TV articles there is overall low breast awareness. Nearby Kensington and carrying Breakthrough’s messages about breast awareness Chelsea Primary Care Trust will act as the control area for the and risk factors for the disease were generated. These study and the pilot project will run until early 2009. contributed to millions of adults being reached across the UK. By responding quickly to breaking news stories, proactively In 2007/08 we completed phase one – the exploratory research placing interviews with Breakthrough's experts in the media, phase – of the project. This work took place with 500 women and providing clear messages on breast awareness risk factors, in both areas, and also with a number of GPs, practice nurses we ensured that Breakthrough’s key educational messages and surgery staff in the Camden area. The research revealed reached the charity’s target audiences throughout the year. Breast Cancer Awareness Month originated in the United States in the late 1980s – a time when breast cancer wasn’t discussed publicly or openly. October became the month to fundraise, campaign and raise awareness of breast cancer. In 1993, the first Breast Cancer Awareness Month activities took place in the UK. Since then its profile has risen each year. For Breakthrough, Breast Cancer Awareness Month is an opportunity to fundraise, campaign for better services and treatments, and to promote the importance of breast awareness. Report of the Board of Trustees | 15 Articles highlighting Breakthrough’s awareness and risk factor practice staff to improve early diagnosis of breast cancer. As messages appeared in a diverse range of media and included a result, we created and distributed 10,000 of our TLC – Touch daily national news outlets such as BBC News online, the Look Check posters to doctors’ surgeries throughout the UK. Daily Telegraph, The Guardian, the Daily Mail, The Sun and the Daily Mirror, as well as on TV and radio programmes such Breast Cancer Awareness Month as GMTV and Woman’s Hour. Articles were also included in We also put more emphasis on promoting our TLC – Touch key health professional media such as Health Service Journal, Look Check breast health information materials to the public GP magazine, British Medical Association News, Independent during Breast Cancer Awareness Month in October 2007 by Nurse, Pulse and The British Medical Journal. implementing an integrated marketing campaign focusing on the signs and symptoms of breast cancer and targeted In November 2007, we commissioned a survey of 200 at women in the 45–57 age group. We ran advertising and GPs throughout the UK in order to inform and support PR across cinema, national and local press and radio, Breakthrough’s health promotion and influencing work. women’s magazines, and websites most commonly visited This survey helped us to measure GPs’ awareness and by the targeted age group. The campaign was also supported understanding of breast cancer, in particular, and how and by Pearl and Dean, which for the second year running donated when they refer women who present themselves with the four weeks of free advertising space relevant to our target suspected signs and symptoms of breast cancer. The results audience across 300 screens in the UK. Our radio ad ‘Body highlighted the confusion that still exists among GPs on how Talk’, created free of charge for Breast Cancer Awareness they make referrals for breast problems and showed that many GPs are not proactively promoting breast awareness Month by Rainey Kelly Campbell Roalfe, encouraged women to be breast aware by using our TLC – Touch Look Check or screening to women over 50. message and was shortlisted in the ‘Best Use of Creative Radio for Tactical Advertising’ category in the Annual Aerial In December 2007, Sir Martin Evans, winner of the 2007 Awards. A number of our corporate partners also helped us Nobel Prize for Medicine and a Breakthrough trustee and to take our message out to women; these included Marks & Chair of Breakthrough’s Science Committee, was asked to Spencer, Avon Cosmetics, The Bingo Association and ghd. guest produce an edition of BBC Radio 4's Today programme. We used this opportunity to feature Breakthrough on the Together, all of this promotional work proved immensely programme and to highlight the information gleaned from our successful and ensured that we reached millions of people GP survey. The item was carried on Radio 4 news bulletins with our message. As a result, we saw a 627% increase in throughout the day and picked up by other stations and the number of TLC z-cards distributed, a 252% increase in websites. The majority of national newspapers featured articles the number of TLC postcards distributed and 408 TLC posters the following day, and a number of regional newspapers and requested for GPs’ surgeries (in addition to the 10,000 already websites also covered the story. All this activity reached nearly distributed). The TLC and breast awareness pages are the 18 million adults. The Royal College of General Practitioners most viewed content on our website and during 2007 the TLC also featured the results of our survey in their GP newsletter. section averaged 1,520 page views per day; this dramatically peaked at 3,900 page views per day during Breast Cancer This work among GPs highlighted that this was an opportunity Awareness Month in October 2007, an increase of 256%. for Breakthrough to work more closely with them and their This combined work created a significant increase in awareness Suzzanne Abbey-Somers was diagnosed with breast cancer through the NHS Breast Screening Programme. Since then she’s become a ‘one woman awareness messenger’, talking to customers in the shop where she works about the importance of being breast aware and urging them to see their GP if they notice any unusual changes to their breast. She hopes that seeing her working, and laughing, may allay some of the fears women have about the disease and help them to see that there is life after breast cancer. 16 | Report of the Board of Trustees of our TLC message among women and men, up from 6% Future plans to 8% in women and 3% to 5% in men. We will be continuing the implementation of our pilot study in Camden and will then evaluate the results. If the results We are proud of the success of our TLC work, but in order indicate that the pilot has had a positive effect on the to ensure that our TLC message remains as effective a health uptake of screening and that there has been an increased message as possible we spent time evaluating it during awareness of the signs and symptoms of breast cancer 2007/08 and received feedback from thousands of women. then we hope to be able to develop this work further in This feedback has been very positive, with many women order to roll out the project more widely. saying how simple and easy the TLC message is to remember. Feedback about our TLC – Touch Look Check message Responding, reaching, winning has been complimentary, but in order for it to continue Requests for our information materials increased by to help women to remember the signs and symptoms approximately 65% on 2006/07, with over 80,000 of breast cancer we will be looking at ways to develop publications disseminated. 1 in 14 visitors to our website TLC further so that it remains a compelling health message. now downloads one of our health information publications, We will also be researching new ways to promote it, with Alcohol and Breast Cancer Risk: The Facts being the particularly to women aged 45–57. most popular download. We will be developing the work we have begun with GPs During Breast Cancer Awareness Month there was also and healthcare professionals. We know that they play a key a surge in requests from members of the public for copies role in communicating with women and in helping them to of Breakthrough’s Breast Cancer Risk Factors: The Facts identify the signs and symptoms of breast cancer, so we will booklet, with 3,544 copies of this publication distributed be exploring ways to enhance our relationship with them. during the month. There were also 149 downloads of a We will also be investigating whether there are resources special edition for practice nurses in the same period. and tools we can develop that would enable healthcare professionals to communicate breast awareness messages In September 2007 our Breast Cancer Risk Factors: The more widely and persuasively. Facts booklet won the 2007 BMA Patient Information Award. The Best Treatment: Your guide to breast cancer treatment We will be looking at ways to continue building on and in Scotland came runner-up in July in the 2008 Ask About developing our range of award-winning information materials, Medicine Excellence Awards in the ‘Improving communication so that they continue to be a useful resource for those between patients and health professionals’ category. affected by breast cancer. Suzzanne also encourages women to attend their breast screening appointments. In her words: “I get chatting to women every time they come in the shop. I explain that I had breast cancer that was picked up through a mammogram before I had any symptoms that could be seen or felt and I wasn’t feeling unwell. I urge women to see their GP if there is even the slightest change or mark to their breast and to go for their mammograms when invited.” Report of the Board of Trustees | 17 Funding our Work Breakthrough relies almost entirely upon voluntary donations to fund its work. We are therefore immensely grateful for the generosity and commitment shown to Breakthrough's work by all our supporters – from individuals and Groups to corporates and charitable trusts. Much has been achieved as a result of our fundraising, but as Crocus Walks and the £1,000 Challenge. To respond as we approach the tenth anniversary of the opening of the to these challenges and facilitate longterm sustainable Breakthrough Research Centre we are aware that much fundraising, we have restructured some of our fundraising more still needs to be done. teams and increased our investment in specific areas. These commitments will require time, money and effort in the short Grants and corporate fundraising continue to be essential to term, but we are confident that this is the best strategy to Breakthrough’s income, but we have a duty to ensure that all ensure that Breakthrough can plan for the future and achieve areas of our fundraising deliver effectively for us. Furthermore, the objectives we have set ourselves. But our work doesn’t as competition for charitable funds intensifies we need to stop there – as well as raising money we also know that we make certain that our fundraising is not only productive today have a duty to ensure that every penny of our income is spent but also reliable and sustainable for tomorrow, so that we can wisely, efficiently and effectively. be confident of raising the funds we need to achieve our vision – a future free from the fear of breast cancer. Some highlights from 2007/08 During 2007/08 income from our fundraising activities was In 2007/08, therefore, we appraised the performance of our £19 million, and total costs of fundraising, excluding sale fundraising teams and evaluated whether they were delivering of goods, amounted to 30p in each £1 raised. Although as productively as possible for us. Our analysis revealed that total income for the year fell short of the ambitious target while some areas of our fundraising were thriving, others were we had set ourselves, in part due to the tightening economic doing less well due to under-investment over the years. Our conditions, the year contained many highlights. These included: research also indicated that there were significant areas of our fundraising we needed to develop: these included recruiting • The glittering success of the Disco and Diamonds Ball in more individual donors who give by regular Direct Debit or January 2008, which brought the £12 million Breakthrough through Give As You Earn, increasing our legacy donations, Generations Study Fundraising Appeal to a close ahead of and building on the success of fundraising campaigns such schedule with £1.5 million raised on the night. Breakthrough Below: We are grateful for the continued commitment of Marks & Spencer and the enthusiastic fundraising of their staff in support of our work. Left: The success of the Breakthrough Generations Study Fundraising Appeal was made possible due to the unwavering commitment of the Appeal Board, under the leadership of Mervyn Davies. 18 | Report of the Board of Trustees owes a huge debt of gratitude to the Appeal Board and enthusiasm they not only raise money but also help us to to all those who made the evening such a success. boost our profile and spread our health awareness messages. In 2007/08 our Groups raised over £770,000 for Breakthrough, • The continued support of Marks & Spencer and Avon a 4% increase on the previous financial year. We now have Cosmetics – two of our longest-standing corporate supporters 50 Groups throughout the UK, all raising funds and awareness – whose continued commitment to Breakthrough’s work for Breakthrough. generated over £3 million in 2007/08. A special mention must also be made of the Isle of Man Group, • The energy and creativity of Breakthrough’s £1,000 which in June 2008 was recognised with a Queen's Award Challengers, which continues to inspire us. Set the target for Voluntary Service, an acknowledgement of their incredible of raising £1,000 in whatever way they choose, the growing fundraising and awareness-raising work. family of Challengers now raises close to £1 million a year – an extraordinary achievement for each of them and an Individual supporters enduring tribute to those family and friends they nominate to Alongside the valued support of companies and our own be recorded on the Challengers’ Walls at the Breakthrough network of volunteer fundraisers and eventers, Breakthrough Research Centre. relies increasingly upon the committed and ongoing support of those who make regular donations and cash gifts to • All those people who have raised money for Breakthrough Breakthrough’s work. Last year, this amounted to some by donning their running shoes and taking part in running £1.8 million, including over £1 million from regular Direct events, treks and bike rides. Our runners alone sprinted Debit income. their way to a 30% increase in funds on 2006/07 raised through sponsorship. More and more people are also now deciding to leave a gift to Breakthrough in their Will. In 2007/08 this amounted to over • The continued commitment from our celebrity supporters, £400,000, a 50% increase on the previous year. Supporting who helped to raise awareness of our work, drive fundraising Breakthrough in this way helps us make longterm plans to and generate press coverage at both regional and continue with our groundbreaking work in research, education national levels. and campaigning in future years. Fundraising Groups We continue to receive significant support through In Memoriam Our Groups remain a bedrock of Breakthrough's fundraising; donations and Crocus Tribute Funds set up in memory of a loved their passion, commitment and dedication are both inspiring one to honour and celebrate their lives. Over £330,000 was and humbling. Group volunteers are at the frontline of our raised for Breakthrough in this way during 2007/08. A special fundraising, but they are not just fundraisers; they are also thank you goes to the family and friends of Sarah Greene, who ambassadors for Breakthrough. Through their support and sadly died of breast cancer in 2006. An extraordinary £77,000 Left: The generosity of Walk the Walk, which has seen thousands of people pounding the streets in support of breast cancer charities, has enabled key major Breakthrough research projects to get up and running. Above: Our thanks to Avon Cosmetics for their ongoing support and commitment towards Breakthrough's work. Report of the Board of Trustees | 19 Left: Thank you to our 50 Groups nationwide who continue to raise the profile of Breakthrough while also bringing in essential funds. Above: We believe that fundraising for Breakthrough should be enjoyable. Pink Parties are a great way to get together with friends, have fun and raise money. has been received at Breakthrough in 2007/08 from the Greene We are immensely proud about the opening of the new family, for which we are extremely grateful. The family is aiming Breakthrough Research Unit in Edinburgh. As our work to raise £250,000 towards research into triple negative breast expands in Scotland, we are particularly excited by the cancer taking place at the new Breakthrough Research Unit at support we have received from the Miss Agnes H Hunter’s King’s College London. Trust towards our work at the new unit. Charitable grants Corporate supporters Grants remain an important source of funding for Breakthrough Our financial year 2007/08 opened with pessimistic and in the financial year 2007/08 we received nearly £1 million predictions for the economy and continued against a from trusts and foundations. This money often provides either downturn in consumer spending. Despite the impact of this essential start-up costs or strategic funding for individual on many of our corporate supporters, we are proud to report discrete projects and is a funding stream that is particularly that our corporate partnerships remained strong during the cost-effective. year and brought in nearly £6 million for Breakthrough. This is consistent with results from the previous year despite Our relationship with Walk the Walk, which stages the difficult trading conditions. renowned MoonWalks and SunWalks, continues to go from strength to strength and during 2007/08 they granted us The benefit of our corporate partnerships cannot be measured £2 million. This takes Walk the Walk’s total commitment to purely in financial terms. They also help us to get our breast over £10 million, £4 million of which has helped to fund the awareness messages out to women. Particular thanks must Breakthrough Generations Study. Other research benefiting go to Avon Cosmetics and Marks & Spencer, who remain from their support in 2007/08 included the Nina Barough immensely supportive in helping us spread our TLC – Touch Pathology Laboratory (named in honour of Walk the Walk’s Look Check breast awareness messages. We believe the founder), the Molecular Pathology Laboratory, the Microarray fact that our corporate partnerships remained so strong Facility, and the ACU Fatigue Trial to investigate whether during such a challenging financial year is testament to the acupuncture may relieve cancer-related fatigue. importance our partners attach to Breakthrough and what we are trying to achieve – a future free from the fear of breast cancer. We are grateful to be able to report that we have again benefited from the generosity of the Mary-Jean Mitchell Green Foundation. Their donation of £292,000 will provide funding for Professor Mitch Dowsett’s research into hormone-sensitive breast cancer. 20 | Report of the Board of Trustees Fundraising Income 2007/08 £19m From cycling and running to walking, rowing, knitting, dancing... The list is endless and our £1,000 Challengers continue to be an inspiration. £6.6m Events and campaigns £5.9m Corporate partnerships £2.3m Community and Groups £2.2m Individual donations Future plans £1m Trusts In 2008/09, we have set ourselves the target of raising £404,000 Legacies £18 million to fund the work that we need to do. As we £649,000 Sale of goods look ahead, we plan to strengthen areas of our fundraising so as to provide greater certainty of income into the future, while continuing to develop our existing partnerships and volunteer and fundraiser networks. In expectation of recessionary impacts in the economy we have built Total Expenditure contingencies into our planning, where possible, to meet any shortfalls in income and will continue to rely upon the extraordinary commitment of our supporters to ensure that we can maintain the pace of our work, even in difficult times. We will be developing new and cost-effective methods for recruiting new supporters, with a target of 7,000 new 2007/08 £18.6m individual donors to be recruited by the end of 2008/09, and engaging more charitable trusts and major givers in specifically funding the work of our new research units. Following a review of Fashion Targets Breast Cancer, we will be refocusing the campaign to retain and attract the support of fashion retailers and increase the income raised. We will also be injecting new energy into our key campaigns, such as the £1,000 Challenge, Pink Your Party and Crocus Walks, to ensure that they remain powerful opportunities for fundraising and attractive to existing and new supporters. grants management £6m Fundraising costs £4.2m Education, policy and influencing £494,000 Cost of sale of goods £107,000 Governance costs £7.8m Research grants and research Report of the Board of Trustees | 21 Our People, Practices and Technology We believe that people work best when they do not have to worry about day-to-day needs, when they are confident they have what they need to do their job, when policy and guidelines are clear and when they feel involved and significant. In 2007/08, we worked to ensure that our systems were wants to achieve as an organisation, while 97% of respondents maintained and improved, that our policies and procedures indicated their understanding of how their role contributes remained fit for purpose, and that our staff were provided with to the charity’s success. A particularly positive year-on-year appropriate training and development opportunities. We also trend was a 10% increase in the number of staff who feel that invested in the development of our managerial competencies Breakthrough values diversity. We were also pleased to see and effective organisational leadership. Our efforts were that 98% of our staff felt proud to work for Breakthrough; recognised with Investors in People reaccreditation in this compares favourably with the 85% of sector scores for December 2007. medium-sized charities. Systems, technologies and procedures Volunteers We know that having a smooth-running IT infrastructure is Volunteers are integral to helping Breakthrough fulfil its vision. essential in order for staff to be confident that they can carry out their work promptly and efficiently. As part of our progress Thousands of volunteers throughout the country help us to towards continual improvement, we continue to benchmark raise funds and awareness as well as campaign to keep the our IT and HR functions against other charities by taking issue of breast cancer on the political and health agenda at part in an independently run annual survey. The results of both local and national levels. our IT survey in 2007/08 showed that our support, security procedures and development are as good as, or better than, Our head office volunteers provide invaluable support, from charities of a similar size. helping teams with day-to-day administration and support at events to using their skills, knowledge and experience on Developing our staff specific projects. Since 1999 over 500 volunteers have given To develop the competencies of our staff we launched a more than 50,000 hours of their time to support Breakthrough. successful training calendar in November 2007 to highlight the range of training opportunities available. This calendar During 2007/08 we developed the Breakthrough ‘talent pool’. will be enhanced for 2008/09, taking into account shifting This is a framework whereby volunteers with specialist skill organisational priorities, individual personal development sets are able to assist Breakthrough with their professional plans and team objectives. expertise. Examples of specialist contributions include advising Breakthrough on its investments, carrying out health and safety In 2007/08, we introduced an annual appraisal framework audits, and providing help and advice on specialist IT projects. with individual objectives, personal development plans and quarterly reviews for all staff. We will be developing this Future plans model, with the input of staff, during 2008/09. We are reviewing a number of staff benefits in order to ensure that our benefits portfolio remains appropriately During 2007/08 we also launched a senior management competitive against those of comparable organisations. team development programme, including coaching and a 360 degree appraisal for each of our directors. In 2008/09, we plan to update our finance system. The existing software has been in use for over eight years, Attraction and retention during which time our income has quadrupled. In October 2007, we attended the Forum 3 recruitment fair in London. Approximately 200 people who visited our stall As the charity has grown our processes have developed signed up to receive job alerts whereby the details of our and adapted to change. In 2008, we will be starting a vacancies were emailed directly to them. Process Improvement initiative, with the help of a dedicated staff member, to ensure that all that we do is as efficient Every member of Breakthrough’s staff contributes to our success. The response rate to the 2007 staff opinion survey was 85% and the results were very positive. 100% of respondents indicated their awareness of what Breakthrough 22 | Report of the Board of Trustees and effective as possible. Structure and Governance We believe that sound and clear governance arrangements lead to better decision making and we aim to ensure that our arrangements are open, transparent and in line with best practice. Organisational structure Development Session, and shorter development and training The trustees have legal responsibility for the strategic direction sessions are included in the board programme throughout and effective governance of the charity. The trustees, also the year. being directors of the company, who served during the year to 31 July 2008 are listed on page 46. On average, the board Chief Executive meets six times per year. The Chief Executive is responsible for the day-to-day management of the charity’s affairs and for the implementation Trustees recruitment, appointment, induction and training of policies agreed by the board. The Chief Executive is assisted Breakthrough currently has fourteen trustees. Together they by the senior management team, staff and volunteers. The provide the broad range of skills and expertise that the trustees board approves the delegation of financial authority through want represented to ensure a strong board – these include the Chief Executive to the charity, with specific limits imposed scientific backgrounds, strategic thinking, financial and within an approved scheme of delegation. organisational management, HR skills, and marketing and legal experience. In addition, many of the trustees have Board delegation personal experience of the impact of breast cancer on people’s The board delegates the exercise of certain powers in lives and so are empathetic towards the goals of the charity. connection with the management and administration of the charity, with regular reporting to the board ensuring that all New trustees are recruited by a procedure which includes decisions made under these powers can be ratified by the external advertising, and are selected to meet a clear person full board in due course. specification and to fill any specific skill gaps that have been identified. Each year the trustees review the skills and expertise The Investment Committee is made up of independent of the board (both individually and collectively); the information professionals and trustees. It reviews investment practice gained from this audit informs both the person specification and performance and reports to the board meeting at least for the appointment of any new trustees and the board training twice a year. The committee sets objectives, benchmarks, programme for the year. and the measurement time frame for the Investment Managers. Breakthrough has a well-established induction programme The Science Committee is made up principally of trustees who for new trustees; this includes one-to-one meetings with have scientific and clinical expertise. It provides advice to the the Chief Executive, members of the senior management board on scientific issues and makes decisions as appropriate team and the Company Secretary. New trustees also receive when specific matters are delegated to it by the Board of an induction pack of key documents ahead of their first Trustees. The Science Committee normally meets about five trustee meeting, and are given the opportunity to visit the times per year and receives advice from independent scientific Breakthrough Research Centre. There is an annual Board committees where the majority of members have expertise We are fortunate to have a number of volunteers who assist us with a range of tasks at our head office. Some help out during the day, others come in on Monday and Thursday evenings – our volunteer nights. Our volunteers are all ages, men and women, retired, working and studying. What they have in common is a belief in and commitment towards Breakthrough and what we are trying to achieve – a future free from the fear of breast cancer. Report of the Board of Trustees | 23 specifically relevant to the research under consideration. They are: These independent committees advise on grant applications • Breakthrough Promotions Limited: Breakthrough’s general received through Breakthrough’s specific funding streams, and trading company which carries out sale of Christmas cards receive advice and comments from independent scientists and and gifts by mail order, raffles, licensing of the logo for clinicians from around the world through a process called peer commercial promotions and conferences. In addition, the review. Such independent experts carry out an assessment company is the owner of the rights to, and operator of, of grant applications submitted to Breakthrough, reviewing the Fashion Targets Breast Cancer Campaign in the United a number of criteria such as scientific quality, strength of Kingdom, and runs this major fundraising campaign each year. investigators and relevance to breast cancer. • Breakthrough Trading Events Limited: runs major events The Scientific Advisory Committee is made up of independent on behalf of Breakthrough Breast Cancer. scientific and clinical experts from around the world. There are currently eight members on the committee. The role of • Breakthrough Enterprises Limited: is completing activities this committee is to provide independent expert advice to the started in previous financial years, or early in the year under Board of Trustees on Breakthrough’s research portfolio. The report. Future activities will be carried out by the other committee carries out quinquennial (five-yearly) reviews of the subsidiary companies. Breakthrough Research Centre. The first review took place in 2004 and the next review will be in May 2009. The committee Breakthrough also holds an associated undertaking in Pink considers research progress and future plans, rating the overall Ribbon Limited, a company registered in England and Wales. quality within specific categories such as ‘outstanding’ and The company was dormant during the financial year. ‘internationally competitive’. All profits of the subsidiaries are donated to the charity under Grant making Gift Aid rules within nine months of the year end. Grants for the Breakthrough Research Centre are awarded on an annual basis, approved by the trustees in consultation with Risk the Scientific Advisory Committee. Applications for additional Breakthrough has followed its risk assessment process funding for new teams within the centre are scrutinised by peer through which it identifies the major foreseeable risks faced review to international standards. by the organisation, assesses their likely impact and, where appropriate, implements or improves measures to mitigate Grants for the Breakthrough Generations Study are approved the risks. The principal risks and uncertainties faced by the on a five-yearly basis, subject to satisfactory progress reports charity are those shared by many similar organisations and in and achievement of project milestones in each year. our risk map are categorised under the headings Reputational, Operational, Strategic, Commercial, Competitive, Contractual, Five-year grants for research units and clinical researchers Financial, Managerial, Property, Regulatory, Technological, are made following international peer review and scrutiny by Scientific, Specific, Natural or Third Party, and Governance. a panel of independent experts. Annual renewal of funding The trustees and senior management team review and is subject to demonstration of satisfactory progress. update the list of key risks regularly to ensure its continued relevance to the organisation and its environment. Certain risk The trustees make other grants when suitable opportunities areas were reviewed in detail during 2007/08 to check that the exist to further Breakthrough’s research strategy where these controls in place to mitigate each risk were operating effectively arise from the work of our core funded programmes, such as and efficiently. clinical trials, or where specific areas of importance have been identified, such as complementary therapies. Funding for such The trustees have reviewed the major risks to which grants is considered through a competitive process involving Breakthrough is exposed and are satisfied that appropriate independent peer review. systems have been established to mitigate those risks. Relationship between the charity and subsidiaries The trustees are also satisfied that the organisation has Breakthrough Breast Cancer has three wholly owned subsidiary proven processes for dealing with unforeseeable risks. In undertakings registered in England and Wales, all of which are May 2007, the trustees approved the three-year Strategic consolidated in these financial statements. Plan 2007–2010 which identified eight strategic objectives for the plan period. For each objective, the trustees identified the measures and the risks and barriers to success. These are set out in the Strategic Plan. 24 | Report of the Board of Trustees Financial Review Income and surplus available for charitable expenditure 2007/08 £m 2006/07 £m 20.7 23.9 (6.5) (9.2) 14.2 14.7 Charitable Expenditure Summary of fundraising and investment income Income Cost of generating income Surplus available for charitable expenditure 2007/08 Gross income for 2007/08 dropped by 13% from the Research (including grants previous year. There was a 29% fall in the cost of generating income, while the overall net income available for charitable management costs) expenditure fell by only 3.4%. There were two main factors Education, policy and influencing behind this: the difficult economic pressures being felt by Governance 2006/07 2007/08 2006/07 64% 76% 35% 23% 1% 1% supporters of events and campaigns, which caused a drop in income, and the decision to move away from major centrally Charitable expenditure at £12.1 million was 72% of budget. organised events that were costly to run, which resulted in a Research grant commitments were £7 million compared drop in income along with a corresponding fall in costs. Other with a budget of £10 million. This is due to changes in the income streams were maintained at a level similar to 2006/07. timing of the award of funding for our ongoing research commitments, which varies year to year. Expenditure on the Breakthrough Research Centre grant was £2 million less Fundraising Income – £m than the previous year, due principally to changes in teams. 2007/08 2006/07 In 2006/07 we provided nearly £0.9 million for the cost of a clinician scientist and planned to commit a similar amount in £1m £2m £4m £6m £8m £10m £12m Community fundraising 2007/08 but this has been deferred until 2008/09. In 2007/08 we committed £0.5 million to the Manchester research unit compared with £1.7million committed in 2006/07 to the Corporate partnerships other units, Edinburgh and King’s College London. Edinburgh is now fully operational; the other two are expected to be at Events and campaigns full strength by the end of 2008/09. Full details of the grants Individual donations are in note 6 to the accounts. Legacies We spent £0.8 million on our own research management Trusts costs. Our in-house team ensures that we fund and effectively monitor high quality research, communicate clearly the findings of our scientists, and support collaboration between them. 2007/08 £m 2006/07 £m Research (including grants management costs) 7.8 12.1 Education, policy and influencing 4.2 3.7 to develop and strengthen our policy development, provision Governance 0.1 0.1 of information, awareness raising and campaigning at local, 12.1 15.9 Charitable expenditure Summary of expenditure Total charitable expenditure We spent £4.2 million on education, policy and influencing work, an increase of £0.5 million on 2006/07. We continue regional and national levels. The cost of governance of the charity is in line with the previous year and represents 0.8 % of our charitable expenditure. Report of the Board of Trustees | 25 Our policy on reserves is set out in note 1.5 to the financial Total Expenditure 2007/08 £m statements and further details on funds are given in note 17. The trustees confirm that there are adequate assets to meet any liabilities on a fund-by-fund basis. Investments Breakthrough holds investments in accordance with the investment policy approved by the trustees and within the powers set out in the Memorandum and Articles of 2007/08 Association of the Charity. Breakthrough seeks to maximise the returns on investments within the specific requirements of its investment policy and has a moderate attitude to risk with a desire for a balanced portfolio. The minimum grade of investment held directly is grade A. Breakthrough does not invest in companies that actively trade in tobacco products, derive more than 3% of turnover from production or more than 10% of turnover from sale or £5.9 Fundraising costs distribution of tobacco-related products. £0.5 Cost of sale of goods £0.1 Investment management costs Breakthrough matches the type of investment to the underlying £7.8 Research grants and research grants management creditor or reserve in order to make efficient use of reserves £4.2 Education, policy and influencing and to ensure that funds are available to meet its grant £0.1 Governance costs payment obligations. All investments relating to short-term creditors are held in cash while the remaining investments Surplus relating to longer-term creditors and reserves are held in a The outcome for the year, after unrealised investment mix of cash, bonds (medium term) and equities (long term). movements, was a surplus of £1.0 million compared with a budget deficit of £0.3 million. There was a net decrease of Total investments at 31 July 2008 amounted to over £0.5 million in our restricted funds balance. After a transfer to £31.4 million, a decrease of £1.5 million on the previous designated reserves to help fund future expenditure our general year. The unrealised loss on investment assets of £1.2 million funds balance is £5.1 million. This is within the planned range of illustrates the particularly turbulent times being experienced our policy to ensure that we have a minimum reserve covering in the financial markets. The market value of our investments between four and six months forecast non-grant expenditure. at 31 July 2008 was £316,000 greater than their cost. The investment mix was 58% cash (£18.4 million), 18% bonds Reserves (£5.3million) and 24% equities (£7.7 million). We held total reserves of £20.5 million at year end. These were split into general, designated and restricted funds as follows: Further details of investment movements and performance are given in notes 12 and 14 to the accounts. 2007/08 £m Funds balances General funds Our largest portfolio is held with BlackRock Investment 5.1 Managers and is invested in the Charishare (equity) and Charinco (fixed interest) funds. No new cash was added to the portfolio in 2007/08. The total fund value was £9.2 million Designated funds at 31 July 2008, a decrease of 7% from last year. Performance Breakthrough Research Centre 6.7 Breakthrough clinical researchers 1.0 Breakthrough Research Units 2.8 benchmark of 20% Government All Stocks Index + 80% FTSE Investment gains designated fund 3.3 All Share Index (excluding Tobacco and Investment Trusts). Fixed assets fund 0.1 At 31 July 2008 the portfolio exceeded its benchmark by Total designated funds Restricted funds Total funds at 31 July 2008 26 | Report of the Board of Trustees 13.9 1.5 20.5 is measured on a rolling three-year basis, with the aim of achieving total returns that exceed by 1% the composite 0.1% (14.1% against 14.0%). Breakthrough holds an M&G Charibond fixed interest fund as part of our medium-term investments and to diversify the portfolio across more than one fund manager. No new cash financial statements, the trustees are required to: was added to the fund in 2007/08. Performance is measured • select suitable accounting policies and then apply on a rolling three-year basis, with the aim of achieving total returns that exceed by 1% the benchmark of the Government All Stocks Index. At 31 July 2008 the portfolio benchmark per annum over three years was 2.6% against 3.3% for the Government All Stocks Index. them consistently; • make judgments and estimates that are reasonable and prudent; • state whether applicable UK Accounting Standards have been followed, subject to any material departures disclosed and explained in the financial statements; and Fixed assets • prepare the financial statements on the going concern basis Movements in the value of tangible fixed assets during the unless it is inappropriate to presume that the charity will year are shown in note 11. continue in business. Financial statements The trustees are responsible for keeping proper accounting The charity’s consolidated financial statements are set out records that disclose with reasonable accuracy at any time on pages 28 to 44, including the results of the charity’s trading the financial position of the charity and the group and which subsidiaries. They are all wholly owned by Breakthrough and enable them to ensure that the financial statements comply registered in England and Wales. Details are included in note with the Companies Act 1985. They are also responsible for 16 to the financial statements. safeguarding the assets of the charity and hence for taking reasonable steps for the prevention and detection of fraud Breakthrough Breast Cancer, Breast Cancer Care and Breast and other irregularities. Cancer Campaign incorporated a limited company under the name of Pink Ribbon Limited for joint trading activities in Audit information relation to Pink Ribbon. The organisations own equal shares So far as each of the trustees is aware at the time the trustees’ in the company and there are currently no proposals for any report is approved: trading or activity by the company. Further details are given a) there is no relevant information of which the auditors are in note 12. unaware; and b) they have taken all relevant steps they ought to have The financial results of the charity’s regional groups are taken to make themselves aware of any relevant audit included within the consolidated results as they operate information and to establish that the auditors are aware within the same charity registration and are governed by of that information. Breakthrough Breast Cancer’s regional group constitution. Auditors The financial statements are prepared in accordance with Kingston Smith LLP have indicated their willingness to continue in the charity’s governing documents, applicable accounting office and in accordance with the provisions of the Companies standards, the Companies Act 1985 and the Statement of Act 1985 it is proposed that they be re-appointed auditors for Recommended Practice on Accounting and Reporting by the ensuing year. Charities issued in March 2005. Approved and signed on behalf of the Board of Trustees Statement of trustees’ responsibilities The trustees are responsible for preparing the Annual Report Stephanie Monk Duncan Smith and the financial statements in accordance with applicable Chairman Honorary Treasurer law and regulations. 19 November 2008 Company law requires the trustees to prepare financial statements for each financial year in accordance with United Kingdom Generally Accepted Accounting Practice (United Kingdom Accounting Standards and applicable law). The financial statements are required by law to give a true and fair view of the state of affairs of the charity and of the income and expenditure of the charity for that period. In preparing these Report of the Board of Trustees | 27 Consolidated Statement of Financial Activities incorporating an income and expenditure account for the year ended 31 July 2008 Note Unrestricted funds £000 Restricted funds £000 2008 £000 2007 £000 Voluntary income 2 8,759 3,951 12,710 15,383 Other activities for generating funds 2 4,226 1,420 5,646 5,858 Sale of goods 2 649 – 649 1,442 Investment income 3 1,750 – 1,750 1,237 4 4 _ 4 3 15,388 5,371 20,759 23,923 Incoming resources Total Income resources from generated funds Incoming resources from charitable activities Other income Total incoming resources Costs of generating funds Fundraising costs 5 5,496 473 5,969 8,388 Cost of sale of goods 5 494 – 494 800 64 – 64 73 Total costs of generating funds 6,054 473 6,527 9,261 Net incoming resources available for charitable activities 9,334 4,898 14,232 14,662 1,044 6,736 7,780 12,127 4,108 69 4,177 3,633 107 – 107 109 5,259 6,805 12,064 15,869 11,313 7,278 18,591 25,130 Net incoming/(outgoing) resources before transfers 4,075 (1,907) 2,168 (1,207) Transfers between funds (1,351) 1,351 – – Net income/(expenditure) 2,724 (556) 2,168 (1,207) (1,180) – (1,180) 635 1,544 (556) 988 (572) 17,504 2,000 19,504 20,076 19,048 1,444 20,492 19,504 Investment management costs Charitable activities and governance Research grants and research grants management 6 Education, policy and influencing Governance costs Total charitable and governance expenditure Total resources expended Unrealised (losses)/gains on investment assets 7 12 Net movement in funds Total funds at 1 August 2007 Total funds at 31 July 2008 17 All of the above results were from continuing activities and there were no gains or losses other than the above. The notes on pages 31 to 44 form part of these financial statements. 28 | Financial Statements Balance Sheets for the year ended 31 July 2008 Group Charity Note 2008 £000 2007 £000 2008 £000 2007 £000 Tangible assets 11 190 288 190 288 Investments 12 13,037 13,648 13,037 13,648 13,227 13,936 13,227 13,936 Fixed assets Current assets Debtors 13 4,417 3,516 7,803 6,447 Investments 14 18,377 19,250 18,377 19,250 1,574 1,846 1,533 1,614 24,368 24,612 27,713 27,311 14,490 16,903 17,852 19,616 9,878 7,709 9,861 7,695 23,105 21,645 23,088 21,631 2,613 2,141 2,613 2,141 20,492 19,504 20,475 19,490 5,108 5,106 5,091 5,092 13,940 12,398 13,940 12,398 1,444 2,000 1,444 2,000 20,492 19,504 20,475 19,490 Cash at bank and in hand Creditors: amounts falling due within one year 15(a) Net current assets Total assets less current liabilities Creditors: amounts falling due after more than one year 15(b) Total net assets Funds Unrestricted - General Designated (includes £316,000 revaluation reserve) Restricted 17 Total Funds The financial statements were approved by the Board on 19 November 2008 and signed on its behalf by Stephanie Monk Duncan Smith Chairman Honorary Treasurer The notes on pages 31 to 44 form part of these financial statements. Financial Statements | 29 Consolidated Cash Flow Statement for the year ended 31 July 2008 Cash flow Net cash inflow/(outflow) from operating activities 2007 2008 Notes £000 £000 £000 (2,290) (a) £000 3,444 Capital expenditure Purchase of fixed assets (36) (40) Purchase of investments – – Disposal of investments – – (40) (36) Returns on investments and servicing of finance Interest received 810 704 Investment income received 940 533 (633) (339) 64 73 Transfer to current asset investments Investment fees deduction 1,181 971 873 (3,627) (272) 748 Increase/(decrease) in cash in the year (272) 748 Increase/(decrease) in liquid resources (873) 3,627 (1,145) 4,375 Management of liquid resources Increase/(decrease) in cash in the year Reconciliation of net cash flow to movement in net funds Movement in net funds in the year (b) 2008 £000 Notes to the cash flow statement 2007 £000 (a) Reconciliation of outgoing resources before revaluations to net cash inflow from operating activities Net incoming/(outgoing) resources before revaluations Depreciation Investment income received (Increase)/Decrease in debtors (Decrease)/Increase in creditors Net cash inflow/(outflow) from operating activities At 1 August 2007 £000 2,168 (1,207) 134 139 (1,750) (1,237) (901) 2,093 (1,941) 3,656 (2,290) 3,444 Cashflow £000 At 31 July 2008 £000 (b) Analysis of changes in net funds Cash at bank Current asset investments 30 | Financial Statements 1,846 (272) 1,574 19,250 (873) 18,377 21,096 (1,145) 19,951 Notes to the Financial Statements for the year ended 31 July 2008 1. Accounting policies incoming resources or sale of goods for generating funds. The principal accounting policies adopted are as follows: Intangible income and gifts in kind are recognised in the accounts when the value to Breakthrough or the cost to 1.1 Basis of accounting the donor can be quantified. The financial statements are prepared under the historical cost convention, as modified by the inclusion of investments 1.4 Expenditure at market value, and in accordance with applicable accounting Expenditure is accounted for on an accruals basis and standards, the Companies Act 1985 and the Statement of attributed to the appropriate functional classifications within Recommended Practice on Accounting and Reporting by the statement of financial activities. Costs that cannot be Charities published in March 2005. directly attributed are allocated between charitable and other costs on a staff time basis. 1.2 Basis of consolidation The financial statements consolidate the financial statements Costs relating to the sale of goods include the direct costs of the charity and all its trading subsidiaries. The income of purchasing and distributing goods for sale along with and expenditure from trading subsidiaries is consolidated on direct staff time and expenditure and allocated costs a line-by-line basis on the face of the statement of financial associated with selling the goods. activities. The charity has taken advantage of the exemption under Section 230 of the Companies Act 1985 and has not Other fundraising costs include direct staff costs and included a separate income and expenditure account for expenses and allocated costs relating to all fundraising the charity. The net result of the charity for the year was activities except sale of goods. a surplus of £1 million (2006/07: surplus £0.6 million). Grants payable in furtherance of the charity’s objects are 1.3 Income the total amounts granted to external bodies for charitable Income is accounted for on a receivable basis to the extent work. The grants made by the trustees are recognised that amounts are material and there is either a legal entitlement in the statement of financial activities in the year the grant or a pledge before the balance sheet date that has been is awarded, provided a legal or constructive commitment honoured subsequently, with the exception of the income exists. They are disclosed within creditors according to types below. the expected payment date of instalments. Details are given in notes 6 and 15. The income of Regional Groups includes all transactions cleared on the Regional Group bank statements up to the Research Grants Management costs in furtherance year end. of the charity’s objectives include direct staff costs and expenditure and allocated costs related to Donations, legacies and other similar incoming resources research activities. include all unsolicited donations and legacies, and income received in response to direct marketing appeals. Education, policy and influencing costs in furtherance Legacies are taken into account when capable of financial of the charity’s objectives include direct staff costs and measurement and reasonably certain of receipt. expenditure and allocated costs related to education, policy and influencing activities. Sale of goods for generating funds includes income from the sale of tangible goods sold at specified retail prices. Governance includes direct staff costs and expenditure and allocated costs of the overall management of the Other activities for generating funds include all fundraising charity and its subsidiaries. income not classified as donations, legacies and similar Notes to the Financial Statements | 31 Notes to the Financial Statements continued 1.5 Funds 1.7 Valuation of investments In accordance with Charity Commission guidance, General Fixed asset investments are stated at the market value at Funds are the funds available excluding restricted and the balance sheet date. Any realised or unrealised gains designated funds. Breakthrough relies heavily on voluntary are shown in the statement of financial activities. Current income, which inevitably fluctuates. In order to continue investments are shown at cost. the day-to-day operations the trustees have approved a general reserves policy to hold funds equivalent to between 1.8 Value added tax four and six months of the non-grant expenditure forecast Value added tax is only partially recoverable by the charity, for the year ahead. The trustees also wish to make and therefore the non-recoverable element is included in a longterm impact with ongoing funding of top quality the statement of financial activities with the expenditure on research projects. Therefore, in order to provide security which the VAT was charged. for future charitable activities, the trustees have approved a range of policies on designated funds. 1.9 Operating leases Rentals payable under operating leases are charged to the Designated Funds arise when the trustees set aside statement of financial activities on a straight-line basis over unrestricted funds for specific purposes. This gives a more the lease term. Details are given in note 19. accurate picture of the general funds available as a reserve against fluctuating income or to spend on new activities. 1.10 Pensions Contributions payable to the pension scheme (see note 10) Restricted Funds arise when conditions are imposed by are charged to the statement of financial activities in the the donor or by the specfic terms of the appeal and can year to which they relate. only be spent on the activities specified. Details of fund balances are set out in note 17 to the financial statements. 1.6 Tangible fixed assets and depreciation Tangible fixed assets are stated at cost, less depreciation. Assets of under £500 in value are not capitalised but are taken fully as expenditure in the year of purchase. Depreciation is provided by the straight-line method, calculated to write off assets over their estimated useful lives at the following rates: Computers and IT software over 2 to 4 years Fixtures, fittings and office equipment over 2 to 5 years Leasehold improvements over 3 to 5 years 32 | Notes to the Financial Statements Group 2008 £000 2007 £000 Community fundraising 1,817 1,014 Corporate partnerships 3,076 2,845 Events and campaigns 4,232 7,390 Individual donations 2,172 2,768 404 262 27 53 982 1,051 12,710 15,383 2. Fundraising income Voluntary income Legacies Statutory funding Trusts Statutory funding is a Section 64 grant from the Department of Health. Group Other activities for generating funds (through trading companies) 2008 £000 2007 £000 Community fundraising 477 1,299 Corporate royalties and sponsorship 2,820 2,797 Events and campaigns 2,349 1,762 5,646 5,858 Group Sale of goods 2008 £000 2007 £000 Pin badges 244 541 T-shirts and other products 405 901 649 1,442 Group 3. Investment income 2008 £000 2007 £000 Money market and bank deposit interest 810 704 Dividend income and stock interest 940 533 1,750 1,237 Group 4. Other income Fees and royalties 2008 £000 2007 £000 4 3 Notes to the Financial Statements | 33 Notes to the Financial Statements continued Group 2008 £000 2007 £000 877 501 Corporate partnerships, royalties and sponsorship 1,257 1,142 Events and campaigns 1,972 5,284 Individual donations 1,426 981 351 315 86 165 5,969 8,388 5a. Cost of generating funds Fundraising costs Community fundraising Trusts fundraising Fundraising management Group Costs of sale of goods 2008 £000 2007 £000 Pin badges 133 119 T-shirts and other products 361 681 494 800 Group 2008 £000 2007 £000 20,106 22,478 6,033 8,461 Net fundraising income 14,073 14,017 Fundraising ratio 30.0% 37.6% 5b. Cost of generating funds and the fundraising ratio Voluntary income and income from other generating activities excluding sale of goods Fundraising costs excluding sale of goods Group 2008 £000 2007 £000 5,091 7,015 471 – Edinburgh – 918 King’s College London – 841 471 1,759 30 890 6. Grants awarded Research Centre grants Breakthrough Research Centre grant Breakthrough Research Unit grants Manchester Total Research Unit grants Clinical Researcher grants Clinician Scientist Fellowship 34 | Notes to the Financial Statements 2008 £000 2007 £000 316 – – (29) 1,003 1,042 Triple Negative Trial – 185 BRCA Trial (Israel) – 61 NCRI Informatics Initiative – 71 BCCOM Project 59 106 ACU Fatigue 15 300 Total other grants 1,393 1,736 Total grants payable 6,985 11,400 Grants management 795 727 7,780 12,127 6. Grants awarded (continued) Other grants Intramural projects – FGFR1 and HER2 Male Breast Cancer Study Breakthrough Generations Study Grants payable (note 6) £000 Costs of goods sold £000 Staff costs £000 Allocated staff costs £000 Allocated support costs £000 Other direct costs £000 Group Total 2008 £000 Fundraising costs – – 1,449 483 862 3,175 5,969 Costs of sale of goods – 223 98 25 45 103 494 Investment management costs – – – – – 64 64 Costs of generating funds – 223 1,547 508 907 3,342 6,527 6,985 – – – – – 6,985 Research grants management – – 390 106 189 110 795 Education, policy and influencing – – 1,766 250 447 1,714 4,177 Governance costs – – 56 13 22 16 107 6,985 223 3,759 877 1,565 5,182 18,591 11,400 366 3,208 857 1,382 7,917 25,130 7. Analysis of total resources expended Grants payable Total expenditure Total expenditure 2007 The analysis above includes support staff costs and general overheads. These are allocated to the different SOFA expenditure headings on a staff time basis and are made up of the following costs: 2008 £000 2007 £000 Staff costs 877 857 Rent and rates 514 425 VAT costs 210 150 Depreciation 134 139 Training, recruitment and HR team costs 668 517 39 151 2,442 2,239 Other costs Notes to the Financial Statements | 35 Notes to the Financial Statements continued 2008 £000 2007 £000 16 18 – 3 Depreciation 134 139 Operating leases - property 318 266 8. Staff 2008 £000 2007 £000 3,982 3,433 Temporary staff agency fees 120 173 Social security costs 422 361 Pension costs 112 98 4,636 4,065 7. Analysis of total resources expended (continued) Net incoming resources are stated after charging Auditors’ remuneration – audit fees – fees for other services Remuneration of staff totalled Salaries The average number of persons employed by the charity and its subsidiaries during the year was 125 (112.5 in 2006/07). The average numbers of staff analysed by expenditure heading were: 2008 Number 2007 Number 47.5 53.0 6.0 7.0 Research 13.5 11.5 Education, policy and influencing 55.0 36.5 3.0 4.5 125.0 112.5 Fundraising Sale of goods Governance In addition to directly employed staff, the charity’s yearly core grant to The Institute of Cancer Research funds the work of over 110 (2006/07:120) scientists at the Breakthrough Research Centre. The number of employees receiving remuneration of over £60,000 for the year was as follows: 2008 Number 2007 Number £60,001 to £70,000 4 1 £70,001 to £80,000 1 – £90,001 to £100,000 – 1 £100,001 to £110,000 1 – Pension costs for these higher paid employees amounted to £17k (2006/07: £8k). 36 | Notes to the Financial Statements 9. Trustees Breakthrough’s trustees (who are also the company directors) are all voluntary and received nil remuneration during the year (nil in 2006/07). Three trustees (three in 2006/07) received reimbursement for travel and accommodation expenses totalling £1,578 during the year (2006/07 £1,445). Further information about trustees is included in note 23. 10. Pensions The charity operates a group personal pension scheme, the assets of which are held in independently administered funds. The charity contributes by matching employee contributions to their personal pension to a maximum of 5% of gross salary. The charity’s contributions to the scheme amounted to £112k during the year (2006/07: £98k). 11. Tangible fixed assets - Group and Charity Leasehold Computers and Improvements IT software £000 £000 Fixtures fittings and office equipment £000 Total £000 Cost At 1 August 2007 333 299 187 819 – 36 – 36 333 335 187 855 173 207 151 531 Charge for this year 57 54 23 134 As at 31 July 2008 230 261 174 665 Brought forward at 1 August 2007 160 92 36 288 Carried forward at 31 July 2008 103 74 13 190 Additions As at 31 July 2008 Accumulated depreciation At 1 August 2007 Net book values There are no assets held under finance leases in 2007/08. Notes to the Financial Statements | 37 Notes to the Financial Statements continued Investments1 2008 £000 2007 £000 13,648 12,747 (64) (73) – 40 633 299 Net unrealised investment (losses)/gains (1,180) 635 Market value at 31 July 2008 13,037 13,648 2008 £000 2007 £000 12,152 11,886 569 266 12,721 12,152 12. Fixed asset investments – Group and Charity Market value at 1 August 2007 Investment fees deducted Transfer to current asset investments Dividends and interest reinvested Cost at 1 August 2007 Fees deducted, dividends and interest reinvested and transfers to current assets Cost at 31 July 2008 (1) The charity’s investment in its subsidiaries is £103. Breakthrough also holds an investment of £20 for a one-third share in Pink Ribbon Limited. The other two-thirds of the shares are held equally by Breast Cancer Care and Breast Cancer Campaign. All investment assets are held in the UK and are unrestricted. The holdings by fund on a market value basis are as follows: Market value 2007 £000 Fund Asset class Fund manager 2008 £000 Charishare Tobacco Restricted CIF Equities BlackRock 7,670 8,508 Charinco CIF Fixed interest BlackRock 1,548 1,482 Charibond CIF Fixed interest M&G 3,819 3,658 13,037 13,648 Total market value Group 13. Debtors Trade debtors Gift aid due from subsidiary undertakings Other debtors Prepayments Accrued income Other amounts due from subsidiary undertakings 38 | Notes to the Financial Statements Charity 2008 £000 2007 £000 2008 £000 2007 £000 1,237 1,511 304 91 – – 4,696 4,021 1,144 1,210 1,084 1,208 327 319 323 569 1,709 476 1,255 369 – – 141 189 4,417 3,516 7,803 6,447 Market value 14. Current investments – Group and Charity Short term cash instruments and deposits 2008 £000 2007 £000 18,377 19,250 Our largest cash portfolio is held with Blackrock, with a total value of £5 million at 31 July this year. Performance is measured on an annual basis with the aim of achieving income that exceeds the cumulative annual return of the three month Sterling LIBID. At 31 July 2008 the portfolio exceeded its benchmark by 0.2% (5.4% against 5.2%). At the balance sheet date the charity had £4,369,000 of short term cash and deposits held with Kaupthing Singer and Friedlander (KSF). On 8 October 2008 the Financial Services Authority (FSA) applied to the High Court for KSF to be put into administration, having concluded that it no longer met the FSA’s threshold conditions. In common with a number of charities and public bodies, we are currently unable to access our funds and at the date of signing these accounts administration is still in progress. Group Charity 2008 £000 2007 £000 2008 £000 2007 £000 131 195 28 – – – 3,608 4,073 13,359 14,626 13,359 14,626 735 720 726 707 10 869 – – 255 493 131 210 14,490 16,903 17,852 19,616 15. Creditors (a) Amounts falling due within one year Trade creditors Due to subsidiary undertakings Grants (see below) Other creditors and accruals Deferred income – other events Taxation and social security Income received before 31 July 2007 relating to the Walk London event (which took place in London on 8 September 2007) and the Disco and Diamonds event (held on 21 January 2008) was deferred until 2007/08. (b) Amounts falling due after more than one year Grants (see below) 2,613 2,141 2,613 2,141 Research Centre grants £000 Research Unit grants £000 Clinical Researcher grants £000 Other grants £000 2008 Total grants £000 2007 Total grants £000 Outstanding grants at 1 August 2007 9,373 1,759 890 4,745 16,767 11,363 Grants awarded during the year (note 6) 5,091 471 30 1,393 6,985 11,400 Payments made during the year (5,694) (360) – (1,726) (7,780) (5,996) Outstanding grants at 31 July 2008 8,770 1,870 920 4,412 15,972 16,767 8,710 1,730 138 2,781 13,359 14,626 60 140 782 1,631 2,613 2,141 8,770 1,870 920 4,412 15,972 16,767 Analysis of grants creditor due Represented by: Falling due within one year Falling due after more than one year Notes to the Financial Statements | 39 Notes to the Financial Statements continued 16. Subsidiary undertakings The activities of Breakthrough Enterprises Limited and Breakthrough Promotions Limited and Breakthrough Trading Events Limited (as included in the consolidated statement of financial activities) and net assets at year end are as follows: Breakthrough Enterprises Ltd £000 Breakthrough Trading Events Ltd £000 Breakthrough Promotions Ltd £000 2008 £000 2007 £000 170 – 236 406 902 Other activities for generating funds 1,966 3,319 967 6,252 8,232 Total incoming resources 2,136 3,319 1,203 6,658 9,134 Costs of sale of goods 116 – 315 431 273 Other fundraising costs 218 1,129 174 1,521 4,840 Total costs of generating funds 334 1,129 489 1,952 5,113 1 6 3 10 – 335 1,135 492 1,962 5,113 Profit available for gift aid 1,801 2,184 711 4,696 4,021 Gift aid (1,801) (2,184) (711) (4,696) (4,021) Retained profit for the year – – – – – Net assets 6 – 9 15 15 Total Incoming resources Sale of goods for generating funds Costs of generating funds Charitable costs Total resources expended All staff are employed by the charity. Staff costs and other support costs borne by the charity are recharged to the subsidiaries on the basis of the proportion of staff time spent working on the activities of the subsidiaries. 40 | Notes to the Financial Statements 17. Funds The movement of group funds classified in accordance with note 1.5 is as follows: Balance at 1 August 2007 £000 Incoming resources £000 Outgoing resources £000 5,106 14,732 (9,017) – (5,713) 5,108 Avon Clinical Fellowship2 – 437 (437 ) – – – Avon Cosmetics3 – 219 (219) – – – 1,096 – – – 1,700 2,796 2,110 – – – (1,110) 1,000 6,500 – (1,640) – 1,836 6,696 288 – – – (100) 188 2,404 – – (1,180) 2,036 3,260 12,398 656 (2,296) (1,180) 4,362 13,940 Cancer Genome Project 7 – – – – 7 ACU Fatigue – 300 (15) – – 285 – 93 (86) – – 7 – 17 – – (17) – – 134 (134) – – – – 1,846 (1,846) – – – 1,434 1,734 (2,348) – – 820 Breakthrough Research Unit, Kings College London14 – 178 – – – 178 Breakthrough Research Unit, Edinburgh – 11 – – – 11 500 5 (471) – – 34 – 115 (30) – – 85 – 159 (481) – 322 – – 274 (355) – 81 – Nina Barough Pathology Laboratory20 – 180 (193) – 13 – Microarray Laboratory21 – 270 (459) – 189 – 9 – – – – 9 50 27 (69) – – 8 – 20 (783) – 763 – Restricted – Corporate – 8 (8) – – – Total restricted funds 2,000 5,371 (7,278) – 1,351 1,444 19,504 20,759 (18,591) (1,180) – 20,492 Investment gains £000 Transfers £000 Balance at 31 July 2008 £000 Unrestricted funds General1 Designated Breakthrough Research Units 4 Breakthrough Clinical Researchers Breakthrough Research Centre Fixed Assets 5 6 7 Investment Gains 8 Total designated funds Restricted funds 9 Research Grant Tracker BRCA Trial 10 11 Molecular Endocrinology Team 12 Breakthrough Research Centre6 Breakthrough Generations Study13 15 Breakthrough Research Unit, Manchester Clinical Researcher – Dr Kong Translational Research Team Molecular Pathology Team 17 18 19 Education – Isle of Man22 Department of Health section 64 Grant Gene Function Laboratory Total funds 24 23 4,16 Notes to the Financial Statements | 41 Notes to the Financial Statements continued 17. Funds (continued) (8) The trustees have designated a separate investment gains fund to represent unrealised investment gains Note (1) The General Fund represents four months of non grant up to a maximum of 25% of the portfolio value. These expenditure for the year ahead. This is in line with the for immediate expenditure. They are shown separately accounting policies (see 1.5 – Fund Accounting of the from general funds. unrealised gains could reverse and so are not available Notes to these accounts). (9) Walk the Walk has given £300K towards the costs of the (2) £600,000 was set aside in 2002/03 from the funds raised by Avon Cosmetics to cover the cost of the ACU Fatigue complementary therapy study over a period of three years. Avon Clinical Research Fellowship, which has been established at the Breakthrough Research Centre. Three fellowships have been awarded over a (10) A grant has been received for a Research Grant Tracker database. three-year period. (11) A grant from the Stanley Thomas Johnson Foundation (3) This represents the amount raised by Avon Cosmetics has been used to fund the Breakthrough and Cancer during the year for spending at Breakthrough’s Research UK Genetic Breast Cancer Trial. The transfer Research Centre. to general funds is because the expenditure on the trial was recognised in the accounts when the commitment (4) The trustees have designated a separate fund for three units, which will cost at least £13 million over the next was made in 2003/04, and the grant received is being used to fund the actual payment of the commitment. five years. Donations have also been received for the units, including £500,000 from Albert Gubay towards (12) A donation from the Mary-Jean Mitchell Green the cost of the Breakthrough Research Unit, Manchester. Foundation is being used to fund research into the Together these funds represent the cost of the three units molecular mechanisms associated with endocrine- for one year. resistant breast cancer. (5) The trustees have designated a separate fund for a (13) The trustees designated a fund for expenditure on the second clinical researcher, within the Breakthrough Breakthrough Generations Study. This fund was to cover Clinical Researcher Programme, to be funded for a the costs of establishing the Breakthrough Generations period of five years. Study during its first five years, excluding the grant commitments that are already included in the accounts (6) The trustees have designated a fund for future and any ongoing analysis and support costs. Donations expenditure at the centre. The aim is to designate the have been received which free up the designated fund for equivalent of between six and twelve months of centre other uses. Donations to the Breakthrough Generations expenditure, beyond the commitment to the next year's Appeal are restricted to fund the study. Main contributors grant that is made annually and is already recognised in during the year were our guests at the Disco and the accounts. The fund currently stands at the equivalent Diamonds Ball who bought tickets, pledged donations of twelve months of centre expenditure. Donations and won auction items. Other significant contributions of £1 million from Walk the Walk and £855,000 from were made during the year by the Lennox & Wyfold Challengers have also been used to fund activities at Foundation, the Robert Hannay Memorial Charity and the Breakthrough Research Centre. the Sir John Fisher Foundation. (7) The trustees have designated a separate fixed assets (14) Donations totalling £77,000 were made to the Sarah fund to represent the net book value of tangible assets Greene Memorial Tribute Fund and sponsorship totalling used by the charity. over £88,000 was raised by the Pink Power Walk. 42 | Notes to the Financial Statements These donations, plus additional gifts from the Kirby (19) £250,000 from Walk the Walk has been used to fund the Laing Foundation and the Mackintosh Foundation, have Molecular Pathology Team at the Breakthrough Research been used to help set up the Breakthrough Research Centre. Grants were also received from the Alice Ellen Unit, King's College London, and its research into triple Cooper-Dean Charitable Foundation and the Sydney & negative breast cancer. Phyllis Goldberg Charitable Trust. (15) Donations from Miss Agnes H Hunter’s Trust and the Martin Connell Charitable Trust were used to help set up the Breakthrough Research Unit, Edinburgh. (16) A donation of £500,000 was made by Mr Albert Gubay towards the new Breakthrough Research Unit, (20) £180,000 from Walk the Walk has been used to fund the Nina Barough Pathology Laboratory. (21) £270,000 was donated by Walk the Walk, bringing the total income from Walk the Walk (see also numbers 9, 19 & 20 above) to £2 million in the year. Manchester. A donation towards the unit was also made by the Mrs Waterhouse Charitable Trust during the year. (22) Jennifer Haigh donated £10,000 to fund breast cancer education and awareness work on the Isle of Man from (17) A grant from the Holbeck Charitable Trust has helped 2006 to 2025. Breakthrough to establish a Clinical Research Fellowship which has been awarded to Dr Anthony Kong. A donation (23) A Department of Health Section 64 grant was made from the Tolkien Trust has also been used to help fund towards improving breast cancer awareness in women this Oxford-based research. aged over 50. (18) A second donation from the Mary-Jean Mitchell Green (24) A donation from the Isle of Man Anti-Cancer Association Foundation is being used to fund Breakthrough’s has been used to help fund the work of the Gene Function Translational Research Team based at the Royal Laboratory at the Breakthrough Research Centre. Marsden Hospital. The total received from the Mary-Jean Mitchell Green Foundation was £293,000 in 2007/08 (see point 12). Notes to the Financial Statements | 43 Notes to the Financial Statements continued 18. Fund balances at 31 July this year are represented by: Tangible fixed assets Fixed asset investments Unrestricted funds £000 Total 2008 £000 2007 £000 190 190 288 13,037 13,037 13,648 9,878 7,709 (2,613) (2,141) 20,492 19,504 Net current assets 8,434 Creditors falling due after more than one year (2,613) Total net assets Restricted funds £000 19,048 1,444 1,444 19. Financial and other commitments Obligations under operating leases Future commitments for operating leases payable for the year ending 31 July 2008 existing at the year end were as follows: 2008 £000 2007 £000 537 537 2008 £000 2007 £000 Within one year 18 17 Within two to five years 27 45 Property leases expiring: Within two to five years Equipment leases expiring: 20. Share capital The charity has no issued shared capital being a company limited by guarantee. 21. Taxation Breakthrough is a registered charity and its activities fall within the exemptions under the Income and Corporation Taxes Act 1988. 22. Contingent liability There were no contingent liabilities. 23. Related party transactions In accordance with FRS 8, the charity discloses related party transactions that were recognised in the statement of financial activities. During the year two Breakthrough trustees were associated with The Institute of Cancer Research. Professor Robert Weiss is a Fellow of the Institute and Susan Johnson is a director of ICR Enterprises Limited. Grants were awarded to The Institute during the year. The total of grants awarded was as follows: Grants to The Institute of Cancer Research There were no outstanding balances due from related parties at the year end. 44 | Notes to the Financial Statements 2008 £000 2007 £000 6,094 8,057 Independent Auditors’ Report to the Members of Breakthrough Breast Cancer for the year ended 31 July 2008 We have audited the group and parent charitable company of the Board of Trustees. We consider the implications for financial statements (the "financial statements") of Breakthrough our report if we become aware of any apparent misstatements Breast Cancer for the year ended 31 July 2008 which comprise or material inconsistencies with the financial statements. Our the Group Statement of Financial Activities, the Group and responsibilities do not extend to any other information. Charitable Company Balance Sheets, the Group Cash Flow Statement, and the related notes. These financial statements Basis of Audit Opinion have been prepared in accordance with the accounting policies We conducted our audit in accordance with International set out therein. Standards on Auditing (UK and Ireland) issued by the Auditing Practices Board. An audit includes examination, on a test This report is made solely to the charitable company's basis, of evidence relevant to the amounts and disclosures in members, as a body, in accordance with Section 235 of the the financial statements. It also includes an assessment of the Companies Act 1985. Our audit work has been undertaken significant estimates and judgements made by the trustees for no purpose other than to draw to the attention of the in the preparation of the financial statements, and of whether charitable company's members those matters which we are the accounting policies are appropriate to the group's and required to include in an auditor's report addressed to them. charitable company's circumstances, consistently applied To the fullest extent permitted by law, we do not accept or and adequately disclosed. assume responsibility to any party other than the charitable company and charitable company's members as a body, for our We planned and performed our audit so as to obtain all audit work, for this report, or for the opinions we have formed. the information and explanations which we considered necessary in order to provide us with sufficient evidence Respective Responsibilities of Trustees and Auditors to give reasonable assurance that the financial statements The responsibilities of the trustees (who are also the directors are free from material misstatement, whether caused by of Breakthrough Breast Cancer for the purposes of company fraud or other irregularity or error. In forming our opinion law) for preparing the Trustees' Annual Report and the financial we also evaluated the overall adequacy of the presentation statements in accordance with applicable law and United of information in the financial statements. Kingdom Accounting Standards (United Kingdom Generally Accepted Accounting Practice) are set out in the Statement Opinion of Trustees' Responsibilities. In our opinion: • the financial statements give a true and fair view, in Our responsibility is to audit the financial statements in accordance with the United Kingdom Generally Accepted accordance with relevant legal and regulatory requirements Accounting Practice, of the state of the group's and and International Standards on Auditing (UK and Ireland). charitable company's affairs as at 31 July 2008 and of the group's incoming resources and application of resources, We report to you our opinion as to whether the financial including the income and expenditure of the group for the statements give a true and fair view and are properly prepared year then ended; and in accordance with the Companies Act 1985. We also report • the financial statements have been properly prepared to you whether, in our opinion, the information given in the in accordance with the Companies Act 1985; and Trustees' Report is consistent with the financial statements. • the information provided in the Trustees' Annual Report In addition we report to you if, in our opinion, the charitable is consistent with the financial statements. company has not kept proper accounting records, if we have not received all the information and explanations we require Kingston Smith LLP for our audit, or if information specified by law regarding Chartered Accountants and Registered Auditors trustees' remuneration and other transactions is not disclosed. Devonshire House 60 Goswell Road We read other information contained in the Annual Report, and London EC1M 7AD consider whether it is consistent with the audited financial statements. This other information comprises only the Report Date: 28 November 2008 Independent Auditors' Report | 45 Legal and Administrative Details Charity details Science Committee Professor Sir Martin Evans MA (Cantab) PhD (Lon) Patron DSc (Cantab) FRS FMedSci Chair HRH The Prince of Wales Professor Robert A Weiss FRCPath Hon FRCP FRS Professor Dame Lesley H Rees DBE MD DSc FRCP FRCPath Board of Trustees Professor Irving Taylor MD ChM FRCS FMedSci FRCPS Members of the Board during the year and at the time of (Glas) Hon signing the report were: Sarah Illingworth MVA Stephanie Monk CBE FIPD Chairman Scientific Advisory Committee Evelyn Smith LLB (Hons) Vice-chairman Professor Nancy Hynes Chair (appointed November 2007) Duncan Smith FCA BSc Honorary treasurer Professor René Bernards PhD Judy Atchison BA (Econ) Hons Dip BA Professor Mina Bissell Jan Brooks MBE MA (appointed 19 September 2007) Professor Adrian Harris MD ChB Professor Sir Martin Evans MA (Cantab) PhD (Lon) Professor Nicholas Hastie CBE FRS FRSE FMedSci DSc (Cantab) FRS FMedSci Professor C Kent Osborne MD Sarah Illingworth MVA Professor Marc van de Vijver MD Susan Johnson BA (Hons) (appointed 22 November 2007) Professor Karen Vousden FRS Peter Keemer MPhil Caroline Mawhood BSc (Soc) CPFA Chief Executive Professor Dame Lesley H Rees DBE MD DSc FRCP FRCPath Jeremy Hughes MA (Oxon) Professor Irving Taylor MD ChM FRCS FMedSci FRCPS (Glas) Hon Company Secretary Professor Hilary Thomas MA (Cantab) PhD FRCR FRCP Jennifer Burley BA (Hons) Solicitor Professor Robert A Weiss FRCPath Hon FRCP FRS Senior Management Team Investment Committee Jeremy Hughes (Chief Executive) Duncan Smith FCA BSc Chair Maggie Alexander (Policy and Campaigns) Peter Keemer MPhil Chris Askew (Fundraising) Caroline Mawhood BSc (Soc) CPFA Audrey Birt (Scotland) Ian Sims BSc Jane Crumpton-Taylor (Resources and Planning) Anne Wade BA (Hons) Dr Norman Freshney (Research Management) Fiona Hazell (Marketing and Communications) Remuneration, Nomination and Executive Appointments Committee Stephanie Monk CBE FIPD Chair Judy Atchison BA (Econ) Duncan Smith FCA BSc Evelyn Smith LLB (Hons) Risk Management Committee Evelyn Smith LLB (Hons) Chair Sarah Illingworth MVA Peter Keemer MPhil Professor Hilary Thomas MA (Cantab) PhD FRCR FRCP 46 | Legal and Administrative Details Auditors Research Centre Kingston Smith LLP The Breakthrough Toby Robins Breast Cancer Devonshire House Research Centre 60 Goswell Road Mary-Jean Mitchell Green Building London EC1M 7AD The Institute of Cancer Research 237 Fulham Road Bankers London SW3 6JB Co-operative Bank plc Director: Professor Alan Ashworth, FRS 9 Prescot Street London E1 8BE Research Units Breakthrough Breast Cancer Research Unit HSBC Bank plc Edinburgh Cancer Research Centre 16 King Street University of Edinburgh London WC2E 8JF Western General Hospital Crewe Road Registered Office Edinburgh EH4 2XR Weston House Directors: Professor Mike Dixon & Professor David Harrison 246 High Holborn London WC1V 7EX Breakthrough Breast Cancer Research Unit Tel: 020 7025 2400 King's College London School of Medicine Email: [email protected] Academic Oncology – 3rd Floor Bermondsey Wing www.breakthrough.org.uk Guy's Hospital Great Maze Pond A company limited by guarantee registered in England London SE1 9RT and Wales (number 2848982), and a charity registered Director: Dr Andrew Tutt in England and Wales (number 1062636) and Scotland (number SC039058). Breakthrough Breast Cancer Research Unit Cancer Research UK Department of Medical Oncology Its governing documents are its Memorandum and Christie Hospital NHS Foundation Trust Articles of Association. Wilmslow Road Manchester M20 4BX Directors: Professor Anthony Howell, Professor Charles Streuli & Professor Nigel Bundred Legal and Administrative Details | 47 Thank You We rely upon hundreds of thousands of people each year Thanks to Elaine Ellison and Ursula Van Mann for their work to support our work but we would like to pay special with the Campaigns Forum. thanks to the following individuals and organisations who have supported Breakthrough Breast Cancer Thanks to members of the Genetics Advisory Panel for during 2007/08. informing our genetics work; Tracy Selwyn; Joan Nicholson; Alison Attard; Lorraine Massey; Maria Boyle; Celia Webber; Research Jackie Goodridge; Margaret Hughes; Linda Edmondson; Breakthrough is very grateful for the time and expertise Linda Shepherd; Barbara Langdale; Gill Marsh; Mary Kennedy; committed by the scientific and clinical experts that it Charlotte Wright; Oonagh Wilson; Ayesha Owusu-Barnaby; consults during the peer-review process and who serve Kerry Andrew and Rachel Seddon. in an advisory capacity as a lay, scientific or clinical expert on the following committees. Thanks to all members of the Genetics Reference Group. Breakthrough Scientific Advisory Committee: Professor Thank you to members of our Clinical Experts Reference Nancy E Hynes (Chair); Professor René Bernards; Professor Group, many other clinical and scientific experts and CAN Mina J. Bissell; Professor Adrian L Harris; Professor Nick members from across the UK who have informed our work, Hastie; Professor C. Kent Osborne; Professor Marc van assisted in developing our information materials and helped de Vijver and Professor Karen Vousden. to inform our response to consultations on issues relevant to those affected by breast cancer, including: Dr Alison Jones; Breakthrough Clinical Researcher Committee: Professor Ms Dawn Chapman; Mr Gordon Wishart; Mr Clive Griffith; Stan Kaye (Chair); Professor Robert Brown; Professor Mr Tim Archer; Mr Christopher Hinton; Dr Margaret Spittle; Peter Barrett-Lee; Professor Nicholas Lemoine and Ms Vikki Hamer; Ms Chris Jacobs; Mr Andrew Baildam; Professor Per Lønning. Ms Charlotte Beardmore; Dr Lucy Brazil; Dr Peter Canney; Dr Suzy Cleator; Professor Jack Cuzick; Professor J Michael Breakthrough Intramural Research Committee: Professor Dixon; Dr Ros Eeles; Dr Paul Ellis; Dr Jacqueline Filshie; Frances Balkwill (Chair); Professor Ian Tomlinson and Professor WD George; Sheila Goff; Lis Grimsey; Dr Ian H Professor Iain McNeish. Kunkler; Dr Michelle Harvie; Elaine Heaney; Professor Shirley Hodgson; Professor Tom Lennard; Dr George Lewith; Breakthrough Generations Study – Advisory Committee and Dr James Mackay; Dr Jane Maher; Miss Jo Marsden; Oversight Body: Professor Flora van Leeuwen; Professor Mrs Jan Morrison; Professor David Peters; Professor Arnie Leslie Bernstein; Professor Tim Bishop; Pat Fairbrother; Purushotham; Dr Gita Ralleigh; Mr Richard Sainsbury; Jan Brooks; Cathy Scivier; Jonathan Kipling; Professor Dr Carmel Sheppard; Dr Amanda Sutton; Dr Andrew Tutt; Mel Greaves; Professor Keith Willison; Jane Stephenson Professor Leslie G Walker; Miss Philippa Whitford; Ms Nikki and Dr Mike Crumpton. West; Dr Mike Michell; Ms Terri Baxter and Dr Brian Fisher. Policy and Campaigns Thank you to the officers of the All Party Parliamentary Group Thank you to members of the Campaigns & Advocacy on Breast Cancer for their work and support: Annette Brooke Network and the CAN Steering Group; Pam Allinson; MP; Ann Cryer MP; Baroness Morris of Bolton; Sharon Dorothy Head; Pat Fairbrother; Shirley Garman; Maureen Hodgson MP and Anne Milton MP. Lubert; Jean McGregor; Penka Nikolova; Caroline Sharpe; Ursula Van Mann; Maggie Wilcox; Charlotte Wright. Our thanks go to all other MPs, Peers, AMs and MSPs who have supported Breakthrough’s campaigning work. Thank you to members of the CAN Training Advisory Group In particular thank you to Kevin Barron MP; Michael Jack MP; for informing the CAN learning and development programme; John Baron MP; Dawn Butler MP; Mike Penning MP; Brookes Charlotte Wright; Amanda Love; Mary Jennings; Pip Gallop; Newmark MP; Susan Kramer MP; John Leech MP; Julia Ann Davis; Alison Walker; Ursula Van Mann; Sandra Kilpatrick Goldsworthy MP; Jane Hutt AM; Richard Lochead MSP; Helen and Gilly Burn. Eadie MSP and Baroness Delyth Morgan of Drefelin.Thank 48 | Acknowledgments you to Service Pledge leads who volunteer their time to work We would also like to thank Evans; House of Fraser; Vileda; with us on this key project: Terry Jemison, Castle Hill Hospital; Mattel; The White Company; The Pier; Taylors Bulbs; Orla Dawn Symonds, Buckinghamshire Hospitals; Julie Calcuth, Kiely; Freemans; Laura Ashley; Topshop; Novartis; Pfizer; Ipswich Hospital; Kim Collingridge, Ipswich Hospital; Susan AstraZeneca; Roche; Paperchase; Abbot Molecular; AGV Merry, Royal Surrey County Hospital; Nicky Turner, Grantham Sports; Keith Hall; Scholl; The Football Association and Hospital; Jo Divver, Lincoln Hospital; Jennifer Hinchcliffe, Raleigh for their valued support. Lincoln Hospital; Doreen Macaskill-Refaat, Pilgrim Hospital; Linda Fisher, Pilgrim Hospital; Clare Sullivan, The Harley Street Trusts and Major Donors Clinic; Sue Ledden, Scarborough General Hospital; Andrea We would like to thank Peter, Alex and Andrew Green for Ward, Scarborough General Hospital; their very generous support through the Mary-Jean Mitchell Sue Baker, Scarborough General Hospital; Louise Sadler, Green Foundation. Friarage Hospital; Judith Curtis, Friarage Hospital; Nikki West, University Hospital of Wales; Karen Wingfield, University Special thanks to Nina Barough and Walk the Walk, everyone Hospital of Wales; Diane Jehu, Prince Charles Hospital; who has taken part in Walk the Walk events this past year, Tanya Ball, Prince Charles Hospital; Ruth Harcourt, Norfolk and to the staff and volunteers who make the walks happen. and Norwich University Hospital; Sandra Griffith, Norfolk and Norwich University Hospital. We very much appreciate the grants and donations received from the following: Amalur Foundation Limited; Ardwick Trust; Thanks to all members of the Service Pledge Advisory Group. The Pamela Barlow Charitable Trust; J L Beckwith Charitable Settlement; Rowan Bentall Charity Trust; Chapman Charitable Donor Marketing Trust; Charly Charitable Trust; Riaz Ahmad Chohan; Peter In honour of the following supporters, we would like to thank Courtauld Charitable Trust; Coutts Charitable Trust; Ronald the following people for leaving a gift to Breakthrough in their Cruickshanks Foundation; Darroch Charitable Trust; Fidelity Will. UK Foundation; Bill Freedman; The Frognal Trust; Clare Joan Wilson; Yvonne A Fontaine; Julie Mindham; David C King Charitable Trust; Mrs F B Laurence's Charitable Trust; Bloomfield; Robert Veitch; Peter E Chesney; Patricia Edwin; Gerald Micklem Charitable Trust; The Monday Club; Morgan J Quantrell; Catherine Gamble; Evelyn M Starkey; Jenny Crucible Company Plc; G M Morrison Charitable Trust; The Brown; Patricia M Howard; Grace A Shippey; Edith G Ardley; New Maclay Murray and Spens Charitable Foundation; Evelyn M Buckley; Florence M Canning; Rosalind England; Pegasus Trust; Tony Rampton Trust; DJ Robarts Charitable Adele V Chambers; Hugh A Murray; Christine E Bass. Trust; Thomas Roberts Trust; The Serve All Trust; Shadworth Hodgson Bequest; Sharegift; Solomon Family Charitable Corporate Partnerships Trust; T & G Midlands Committee; David Uri Memorial Trust; We are extremely grateful to our corporate partners who Wesleyan Charitable Trust. together have contributed nearly £6 million during 2007/08. The Breakthrough Generations Appeal Board In particular we would like to acknowledge and thank Marks Thank you to the members of our Appeal Board whose & Spencer and Avon Cosmetics. Both companies have commitment led the way to raising a tremendous £12 million been generous and loyal supporters of Breakthrough Breast for the Breakthrough Generations Study: Patti Bellinger; Cancer and their commitment to Breakthrough is immensely Linda Cooper; Mervyn and Jeanne Davies; Amelia Fawcett; appreciated. The longstanding commitment and motivation of Joseph Fiennes; Arabella and James Gaggero; Richard and their employees and customers to raise money for Breakthough Kay Harvey; Philip and Val Marsden; Sir Keith and Lady Mills; and to spread our breast awareness messages is exemplary. Roger Urwin. We are also grateful to Gala Bingo and The Bingo Association; Major Breakthrough Generations Appeal Contributors ghd; River Island; Aviva; adidas; Warehouse; Solus Garden Thank you to all of the following whose significant contributions & Leisure; Hamelin Paperbrands and MBNA Europe Bank for enabled us to reach our £12 million target: Luqman Arnold their ongoing and valuable fundraising activities. and Olivant; Simon Bamber; Ian Barlow and KPMG; Ellen Acknowledgments | 49 Thank You continued Brunsberg and Morgan Stanley; Damon Buffini and Permira; Many thanks to Middlesex County Cricket Club; TVQuick and Iain Burton and Aspinal of London; Nic Byrom; Jennifer TVChoice Magazines; Prima Magazine; Universal Pictures; Carmichael; Barry and Sally Clare; Roger Davis; David Dein |The Mail on Sunday; The Inspiration Awards; Stacey Kent and Charitable Settlement; Deutsche Bank; Lloyd Dorfman and the Ladies Golf Union for supporting Breakthrough throughout the Dorfman Foundation; Marcus Evans; Lex Fenwick; Ray the year. Fine; Roddie Fleming and Fleming Family and Partners; David Giampaolo and Pi Capital; Richard Gnodde; John Our thanks also to Standard Chartered; adidas; Capitalize; Hawkins; Andy Higginson and Tesco plc; Gordon and Running4Women; Chester Triathlon Club and the London Francesca Horsfield; Martin Hughes and Toscafund; Marathon Limited for selecting Breakthrough as the preferred Michael Jacobson; Nicholas Jones; Paul Kemsley; Naguib charity on a range of running events. Kheraj; Linda Khoo; Donald Mackenzie; Carolyn McCall and Guardian Media Group; Luke Meynell; Stephen Miron Communications and Advertising and YOU Magazine; Lord Moynihan; Roger Nagioff; Alan Thank you to all the media who have supported us this year, Pascoe; John Paynter; David Pearl; Nigel Rich and SEGRO in particular: Prima Magazine; YOU Magazine, Mail on Sunday; plc; Geoff and Val Richards; Darren Rockman; Roland Rudd; The Sun; Jewish Chronicle; BBC Radio 5 Live; Daily Mirror; Chris Satterthwaite; Joseph Schull; David Shaw; Lorraine Look Magazine; Scottish Television; Edinburgh Evening News; Spencer; Gary von Lehmden; John Wall. Woman's Hour, BBC Radio 4; S Magazine, Sunday Express; Celebs on Sunday Magazine, Sunday Mirror; Take it Easy Supporter Fundraising Magazine, The People. A huge thank you to our 50 Breakthrough Groups who continue to demonstrate the spirit of Breakthrough across Thank you also for the ongoing invaluable support from: the UK, helping to raise vital funds and awareness of breast Gaby Roslin; Joseph Fiennes; Edith Bowman; Alan Carr; cancer in their communities. Anna Friel; Natalie Imbruglia; Twiggy; Ali Bastian; Gemma Atkinson; Roxanne Pallett; Rankin. A special thank you to all of our Local Contacts who represented Breakthrough Breast Cancer so well this year Thank you to the members of the Project Advisory Group by supporting our fundraising and awareness campaigns. for our pilot breast awareness project: Lisa Cohen; Ray Lowry; Douglas Eadie; Rita Brophy; Maggie Luck; Rosy Price and We would like to say a huge thank you to the many individual Rosalind Tatham. supporters who in the past year have given up their time and energy and organised a Crocus Walk, taken part in a trek, We are grateful to all companies who have donated professional running event or parachute jump, sold pink ribbon pins, cycled expertise and services to Breakthrough in the period under for Breakthrough, held a Banquet or organised a Pink Party. review, in particular: Posterscope; Viseum; Rainey Kelly Campbell Roalfe; Blue Dog. We would like to express heartfelt thanks to all of our amazing £1,000 Challengers for making this year even bigger than the last. In particular, we would like to acknowledge: Pink Power Walk; Maria Stansfield; Nathan Aldous; Sally Burton; Judith Williamson; Pink Row 08; Gerald White; Nick Doffman & Lloyd Nancy Sorrell; Glenn Flegg & Co; C-Stride; Victoria Ball; Arabella Gaggero; Nancy Roddick; Vivienne Alexander; Janine Clements; Amanda Jones; Jane Scott; Louise O'Reilly; Bridget Ovenden and Ursula Van Mann. 50 | Acknowledgments designed and produced by stillwaters-rundeep.com Simon; Shirley Rutter; Janet South; Katie Hart; Fran Dickson; This is a very important document for everyone... EVERYONE WHO HAS BEEN DIAGNOSED WITH BREAST CANCER EVERYONE WHO IS AFFECTED BY BREAST CANCER EVERYONE WHO HAS LOST SOMEONE TO BREAST CANCER EVERYONE WHO RAISES FUNDS TO FIGHT BREAST CANCER EVERYONE WHO CAMPAIGNS FOR IMPROVEMENTS IN TREATMENTS AND SERVICES EVERYONE WHO FEARS BREAST CANCER this is not a report about financial gain but HUMAN gain EVERYONE WHO CARES FOR FELLOW HUMAN BEINGS EVERYONE WHO BELIEVES IN HUMAN ENDEAVOUR EVERYONE WHO SHARES THE VISION OF A FUTURE FREE FROM THE FEAR OF BREAST CANCER … everyone and that’s it is about the progress IN the fight against breast cancer in the uk the annual report for breakthrough breast cancer 2007/2008 www.breakthrough.org.uk
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