Ayursense Exclusive N.A. Distributor CENTERCHEM, INC. NORWALK, CT Ph: 203-822-9800 Fax: 203-822-9820 www.centerchem.com INTRODUCTION AYURSENSE is a plant based cosmetic product developed to offer SENSATIONS on the skin. These sensations have an influence on the user’s mood providing a state of well-being. AYURSENSE offers a sensation of freshness and overall well-being from plants traditionally used in Ayurvedic medicine. Eclipta symbolizes harmonious functioning of the body, resulting in feelings of freshness, energy and strength with its effects of rejuvenation and longevity. Provital has developed this product to give added value to the final products it is included in, giving the consumer a sensory experience beyond the benefits of the other ingredients contained in the cosmetic. The Sense Range product line pursues improving consumers’ well-being by creating sensations on the skin. AYURSENSE is an extract of Eclipta (Eclipta alba (L.) Hassk = Eclipta prostrata (L.) L.) in Propanediol / Water (50:50). DESCRIPTION SENSATION According to The American Heritage Dictionary, the term sensation (from the latin sensationis), is defined as The impression things produce through our senses A surprise effect, usually pleasant, produced by something amongst a group of people A hunch or premonition that something is about to occur Our senses provide us with vital information that allows us to relate to safely and independently with the world that surrounds us. This is done through feelings, which are used as the mechanism V 02-11/2011 40481-1 by our body to process all the stimuli it receives: light, sounds, textures, tastes, hot or cold, pains, smells, even caresses, feeling tickles and kisses. Touch is the sense responsible for perceiving the stimuli that include contact and pressure, as well as those relating temperature and pain. Our sensory organ is the skin. The majority of feelings are perceived through specialised nerve endings on the skin, which are called touch receptors. These receptors are located on the epidermis, which is the outermost layer of the skin, and they transport feelings towards the brain through nerve fibres. In Cosmetics, we refer to the sensation or effect caused by cosmetics when they are applied to the skin, through touch, and to a lesser extent smell, the pleasurable "surprise" effects they cause. Touch allows us to feel the texture and smell allows us to perceive the aroma. AYURSENSE gives cosmetic products a sensation of freshness and overall well-being. These sensations have a positive impact on the external appearance of the skin, showing fresh, rested and healthy looking skin. BOTANY AND CHEMISTRY Eclipta alba (L.) Hassk = Eclipta prostrata (L.) L. = Eclipta humilis Kunth = Eclipta thermalis Bunge = Eclipta marginata Boiss. = Eclipta erecta L. = Eclipta punctata L. = Verbesina alba L = Verbesina conyzoides Trew. = Verbesina prostata L. Eclipta is the species Eclipta alba (L.) Hassk, belonging Asteraceae family. This species is also commonly known as False Daisy, White Eclipta or Swamp Daisy. This is an herbaceous plant with a tap root. The stalk is erect, rough, fleshy and branching at the base; it can reach up to 1 m in height. The base of the plant is rhizomatous. The leaves are opposite, oval or lanceolate, up to 10 cm long and 3 wide (normally smaller), somewhat rough, margins slightly serrate. Inflorescences are solitary on short peduncles located at the end of the stems, and axillary to the leaves. These inflorescences are made up of small sessile flowers arrayed on a flat receptacle, with very thin bracts. The ligulate female flowers are found on the V 02-11/2011 40481-2 edge of the flower head, while the hermaphrodite flowers are arrayed in the centre. The fruit is an achene containing a single seed. The habitat of this species is tropical and subtropical countries up to 2000 meters high. This plant grows throughout India, especially in humid places. Major components of Eclipta are: coumestans, flavonoids, triterpene saponins and phenol acids. Coumestans structure are isoflavonoids composed of with coumarinic wedelolactone and desmethylwedelolactone. Flavonoids identified in this plant are: apigenin, luteolin, apigenin-7-glucoside and luteolin-7-glucoside. Among the triterpene saponins, two types of ecliptasaponins (C, D) have been identified. Among the phenol acids, benzoic acid derivatives (protecatechuic acid) and cinnamic acid derivatives (isochlorogenic acid and its isomers) have been identified. Further active compounds in Eclipta are: ascorbic acid, phytosterols, (stigmasterol, -sitosterol, amirin), long-chain alcohols, alkaloids (ecliptine), polyacethylene and peptides. Stems and leaves mainly contain coumestans, flavonoids and saponins; roots are rich in long-chain alcohols and sterols. TRADITIONAL USES The whole plant and seeds have great medicinal value, used internally as well as externally. A decoction of the whole plant is used as an anticarcinogenic, astringent, cholagogue, eyewash, emenagoge, febrifuge, fungicide, haemostatic and vulnerary; it has been used as a remedy for alopecia, asthma, bronchitis, kidney stones, diarrhoea, eczema, impetigo, leprosy and psoriasis. The roots are used as an emetic and purgative agent. The leaves of the Eclipta have also been rubbed on children's foreheads to prevent convulsions. It is traditionally used as a hair tonic, and black hair dye. Application of a paste made of Eclipta has been used to treat glandular V 02-11/2011 40481-3 inflammations and to reduce inflammation and pain. This same paste is used to clean and cure wounds. The juice of the plant has been used for eye and ear infections. Eclipta has immunomodulatory activity. It is believed that certain plants have the ability to produce a beneficial effect on our health, by exercising resistance against infections to re-establish the body's balance. This effect is presumably due to a non-specific action of these plants on the immune system. Mixed with other plants it has a beneficial effect for liver ailments, as a diuretic preparation and for treating anaemia. There is a Hindu preparation with Eclipta alba, Andrographis paniculada, Tephrosia purpurea and Terminalia chebula to treat both viral hepatitis A and B. In a clinical study with 63 patients (32 received the preparation and 31 were given placebo), clinically significant improvements were seen in the group receiving treatment. This is a popular, well reputed herb for skin and hair care. It is also the best liver tonic mentioned in many ancient texts, including the Ayurveda books. The juice of the leaf was used as a traditional remedy with honey for children's colds. A formula of the leaf juice boiled with sesame or coconut oil has been used to maintain black hair colour and to prevent hair loss. This species is used a lot in traditional Chinese medicine and in Ayurveda medicine. In India, the plant is known as bhangra, bhringraja or bhringaraja. The Sanskrit word bhringaraja literally means, "That which gives splendid hair colour like the buzzing of bees"; numerous synonyms describe its properties for hair growth, and for making hair black and shiny. It is the most well-known herb for preventing hair loss and premature greying. Some of the synonyms are kesaraja--king of hair, markava--that which prevents premature gray, kesaranjana--gives beautiful dye to the hair, etc. It is an excellent rejuvenative. Ancient texts mention that the person who drinks fresh Eclipta juice daily for a month, and diets primarily on milk, would be rejuvenated and live strong, healthy and happy for 100 years. It is known as “white bhringraj” when it is flowering and “black bhringraj” when it is bearing fruit. V 02-11/2011 40481-4 COSMETIC PROPERTIES AND APPLICATIONS FRESHNESS Freshness or fresh means something cool in comparison to our temperature or ambient temperature. It also means something recent, just prepared or made. Other meanings include showing no sign of fatigue, in other words, rested and also calm. Today, consumers demand cosmetic products with a pleasant texture and offering freshness, luminosity and moisturizing to the skin. The skin recovers flexibility, luminosity, freshness and tone, acquiring a uniform, transparent, velvety and glowing appearance. Freshness in a cosmetic product closes pores, stimulates muscle tone, boosts blood circulation, stimulates internal cell metabolism, has a decongestive effect and alleviates puffiness, among the more valued effects. AYURVEDIC TREATMENT Eclipta has been described as a useful agent for treating Vata and Capa imbalances. Among traditional medicine systems, Ayurveda is recognised by the WHO as a well organised scientific system of medicine for the prevention and treatment of different diseases. Ayurveda literally means "science of life" Ayus are the life cycles that represent the body, mind and senses, and Veda is the knowledge of the world and how its components work. This traditional medicine system believes that everything is made up of the five elements (air, ether, fire, water and earth). These represent the five states of matter or energy. It considers people to be a microcosm within nature where the five elements exist. The ayurvedic system stresses that health is the harmonious functioning of all the parts of the human being (physical, mental and spiritual). Eclipta has been considered with rasayana - herb of longevity and rejuvenation- V 02-11/2011 40481-5 Action Cosmetic application Cosmetic formulas Sun spray Freshness Cool Facial mist Refreshing wipes Relaxing mousse Ayurvedic treatment Anti-aging Nourishing milk Anti-aging gel RECOMMENDED DOSE The recommended dose is between 2% and 5%. BIBLIOGRAPHY Sharma S, Sikarwar MS. Wound healing activity of ethanolic extract of leaves of Eclipta alba. Phcog Mag 2008; 4 (13). 108-111. Muthu C, Ayyanar M, Raja N, Ignacimuthu S. Medicinal plants used by traditional healers in Kancheepuram District of Tamil Nadu, Índia. Journal of Ethnobiology and Ethnomedicine. 2006; 2: 1-10 [consulted 03/03/2008]. Available: http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1615867 Jayathirtha MG, Mishra SH. Preliminary immunomodulatory activities of methanol extracts of Eclipta alba and Centella asiatica. Phytomedicine 2004; 11 (4): 361-365. Wagner H, Bauer R, Peigen X, Jianming C, Grieblinger E. Chinese Drug Monographs and analysis. Herba Ecliptae Mohanlian. 2004; 5 (24). Alonso, J. Tratado de Fitofármacos y Nutracéuticos. Barcelona: Corpus, 2004, p:109. Venkatesan S, Ravi R. Antifungal activity of eclipta alba. Indian Journal of Pharmaceutical Sciences 2004: 66 (1):97-98. Upadhyay RK, Pandey MB, Jha RN, Pandey VB. Eclalbatin, a triterpene saponin form Eclipta alba. Journal of Asian Natural Products Research 2001; 3 (3): 213-217. V 02-11/2011 40481-6 Zafar R, Sagar BPS. In vitro plant regeneration of Eclipta alba and increased production of coumestans. Fitoterapia 1999; 70 (4): 348-356. Phadke SA, Kulkarni SD, Screening of in vitro antibacterial activity of Terminalia chebula, Eclipta alba and Ocimum sanctum. Indian Journal of Medical Sciences 1989; 43 (5): 113-117. Simon FP, Arantes MC, Ribeiro P, Rezende MH, Paula JR, Bara MT. Caracterização farmcognóstica de Eclipta alba (L.) Hassk, Asteraceae (Agraiao do Brejo). Revista Electrônica de Farmácia. 2005; 2 (2):198-201.Consulted 03/03/2008. Available: http://www.farmacia.ufg.br/revista/_pdf/vol2_2_supl/resumos/ref_v2_2_supl-2005_p198201%20Simon.pdf. www.ciat.cgiar.org/riceweb/pdfs/segunda_parte_7.pdf [consulted 03/03/2008]. http://www.itmonline.org/arts/erzhiwan.htm [consulted 03/03/2008]. http://www.ibiblio.org/pfaf/cgi-bin/arr_html?Eclipta+prostrata [consulted 03/03/2008]. http://www.rjb.csic.es/pdfs/Anales_11(1)_281_317.pdf?PHPSESSID=64ff7ad3c34556087a004623 576abf68 [consulted 03/03/2008]. http://sloth.ots.ac.cr/local/florula2/families/ASTERACEAE.pdf [consulted 03/03/2008]. http://www.ars-grin.gov/cgi-bin/npgs/html/tax_search.pl [consulted 03/03/2008]. V 02-11/2011 40481-7
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