TrueMass® Lipid Profiling
Fatty Acids and Sterols: Core Pathways and Functionalities Although lipids are a diverse class of
molecules with many functions, there are only two major building-block pathways. One that utilizes
fatty acids (FA) and another uses sterols (CH). With both seminal lipid pathways, lipid building blocks
are derived from either diet or de novo synthesis. Biology has evolved numerous metabolic pathways
for converting these basic building blocks into complex lipids, signaling lipids, and for catabolizing or
excreting them. Lipomics panels are designed and validated to give complete and quantitative coverage
of the key lipid products of these pathways, offering the ability to understand all major aspects of the
life cycle of these major lipid classes.
Fatty Acid Metab. Panel (FAFP)
Palmitate
n7 fatty acids
n9 fatty acids
n3 fatty acids
n6 fatty acids
All fatty acids
Fatty Acid Metab. Panel (FAFP)
Synthesis
(TMTLP, TMTLT,
TMPL, or TMNL)
Triacylglycerol
Phospholipids
Sphingomyelin
Ceramide Panel (CRFP)
Ceramides
Eicosanoids
Acylcamitine Panel (ACFP)
Acylcarnitines
Cholesterol
b-Sitosterol
Campesterol
Stigmasterol
Nutrition
FA
TrueMass Lipomics Panel
Cholesterol
Cholesterol Metab. Panel (CHFP)
Desmosterol
Lathosterol
7-Dihydrocholesterol
Cholesterol Metab. Panel (CHFP)
CH
TrueMass Lipomics Panel
Complex
Lipids
Cholesteryl ester
Signaling
Lipids
Steroids
Catabolism or
Excretion
Bile Acids
(TMTLP, TMTLT,
TMPL, or TMNL)
Bile Acid Panel (BAFP)
www.metabolon.com
Core Lipid Panels
Lipid Panel Name
Type
Total Lipid Plasma/
Serum Panel
Description
Product Code
Concentration and fatty acid composition* of: cholesteryl ester, free fatty acid,
diacylglycerol, triacylglycerol, phosphatidylcholine, phosphatidylethanolamine and
lysophosphatidylcholine.
TMTLP
Concentration and fatty acid composition* of: cholesteryl ester, free fatty acid,
diacylglycerol, triacylglycerol, phosphatidylcholine, phosphatidylethanolamine,
phosphatidylserine, lysophosphatidylcholine, spingomyelin and cardiolipin.
TMTLT
Concentration and fatty acid composition* of cadiolipin, spingomyelin,
lysophosphatidylcholine, phosphatidylcholine, phosphatidylethanolamine,
phosphatidylserine.
TMPL
Concentration and fatty acid composition* of: cholesteryl ester, free fatty acid,
diacylglycerol, and triacylglycerol.
TMNL
Acylcarnitine Panel
Quantitative data on concentration of: L-Carnitine, Butyrobetaine, Acetylcarnitine,
Propionylcarnitine, Butyrylcarnitine, Valerylcarnitine, Hexanoylcarnitine,
Octanoylcarnitine, Decanoylcarnitine, Dodecanoylcarnitine, Myristoylcarnitine,
Palmitoylcarnitine, Stearoylcarnitine, Oleoylcarnitine, and Linoleylcarnitine.
ACFP
Amino Acid Panel
Quantitative data on concentration of: α-Aminobutyric acid, Alanine, Asparagine,
Aspartic acid, Glutamine, Glutamic acid, Glycine, Histidine, Isoleucine, Leucine, Lysine,
Methionine, Ornithine, Phenylalanine, Proline, Tryptophan, Tyrosine, and Valine.
AAFP
Bile Acid Panel
Quantitative data on concentration of: Cholic acid, Chenodeoxycholic acid, Deoxycholic
acid, Lithocholic acid, Ursodeoxycholic acid, Taurocholic acid, Taurochenodeoxycholic
acid, Taurodeoxycholic acid, Taurolithocholic acid, Glycocholic acid, Glycochenodeoxycholic
acid, Glycodeoxycholic acid, Glycolithocholic acid, and Glycoursodeoxycholic acid.
BAFP
Cholesterol
Metabolism Panel
Quantitative data on concentration of: Cholesterol, Desmosterol, Lanosterol,
Lathosterol, 7-Dehydrocholesterol, Coprostanol, Cholestanol, b-Sitosterol, Campesterol,
Stigmasterol, 7a-Hydroxycholesterol.
CHFP
Fatty Acid
Metabolism Panel
Quantitative data on up to 38 fatty acids*
FAFP
Quantitative and compositional data on up to 62 ceramides (refer to panel sheet)
CRFP
Total Lipid Tissue Panel
Polar Lipid Panel
TrueMass®
Lipomic
Panels
Neutral Lipid Class Panel
Focused
Panels
Ceramide Lipid Panel
Sebum Lipid Panel
Quantitative and compositional data for triacylglycerol, wax ester, diacylglycerol, free
fatty acids and squalene. (refer to panel sheet)
TMSEB
Lipid Class Fractions
Lipid Panel Name
Type
Cholesteryl Ester
Description
Product Code
Concentration and fatty acid composition* of cholesteryl esters
TMFCE
Diacylglycerol
Concentration and fatty acid composition* of diacylglycerols
TMFDG
Triacylglycerol
Concentration and fatty acid composition* of triacylglycerols
TMFTG
Concentration and fatty acid composition* of free fatty acids
TMFFFA
Concentration and fatty acid composition* of cardiolipin
TMFCL
Concentration and fatty acid composition* of sphingomyelin
TMFSM
Free Fatty Acid
Cardiolipin
Sphingomyelin
Lysophosphatidylcholine
Phosphatidylcholine
Phosphatidylethanolamine
Phosphatidylserine
Individual
fractions from
TrueMass
Lipomic
Concentration and fatty acid composition* of lysophosphatidylcholine
TMFLY
Concentration and fatty acid composition* of phosphatidylcholine
TMFPC
Concentration and fatty acid composition* of phosphatidylethanolamine
TMFPE
Concentration and fatty acid composition* of phosphatidylserine
TMFPS
* List of Fatty Acids: 14:0, 15:0, 16:0, 18:0, 20:0, 22:0, 24:0, 14:1n5, 16:1n7, 18:1n7, 18:1n9, 20:1n9, 20:3n9, 22:1n9, 24:1n9, 18:2n6, 18:3n6, 20:2n6, 20:3n6, 20:4n6, 22:2n6, 22:4n6,
22:5n6, 18:3n3, 18:4n3, 20:3n3, 20:4n3, 20:5n3, 22:5n3, 22:6n3, 24:6n3, plasmalogen derivatives of 16:0, 18:0, 18:1n7 and 18:1n9, and trans fatty acids t16:1n7, t18:1n9, t18:2n6.
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