Centrohem
Material Safety Data Sheet
According to EC Directive 91/155/EEC
Fine & speciality chemicals
Section 1 – Chemical Product and Company Identification
Catalogue No.: 26, 633
Product name: Aniline p.a.
Synonyms: Aminobenzene, Phenylamine
Company: Centrohem d.o.o., Karađorđeva 129, 22300 Stara Pazova, Serbia
Emergency telephone No.: +381 63 529560
Section 2 – Composition, Information on Ingredients
CAS-No.: 62-53-3
EC-Index-No.: 612-008-00-7
EC-No.: 200-539-3
M: 93.13 g/mol
Formula Hill: C6H7N
Chemical formula: C6H5NH2
Section 3 – Hazards Identification
Toxic by inhalation, in contact with skin and if swallowed. Limited evidence of a carcinogenic
effect. Risk of serious damage to eyes. May cause sensitization by skin contact. Toxic: danger
of serious damage to health by prolonged exposure through inhalation, in contact with skin and
if swallowed. Possible risks of irreversible effects. Very toxic to aquatic organisms.
Section 4 – First Aid Measures
First-aid personnel: ensure self-protection!
After inhalation: fresh air.
If breathing stops: immediately apply mechanical ventilation, if necessary oxygen mask.
Immediately call in physician.
After skin contact: wash off with plenty of water. Dab with polyethylene glycol 400.
Immediately remove contaminated clothing. Immediately call in physician.
After eye contact: rinse out with plenty of water for at least 10 minutes with the eyelid
held wide open. Immediately call in ophtalmologist .
After swallowing: make victim drink plenty of water, induce vomiting. Immediately call in
physician. Laxative: Sodium sulfate (1 tablespoon/1/4 l water). Immediately call in physician.
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Section 5 – Fire Fighting Measures
Suitable extinguishing media: Water, CO2, foam, powder.
Special risks: Combustible. Vapours heavier than air. Forms explosive mixtures with air on
intense heating. Development of hazardous combustion gases or vapours possible in the
event of fire. The following may develop in event of fire: nitrous gases.
Special protective equipment for fire fighting: Do not stay in dangerous zone without selfcontained breathing apparatus. In order to avoid contact with skin, keep a safety distance and
wear suitable protective clothing.
Other information: Cool container with spray water from a save distance. Contain escaping
vapours with water. Prevent fire-fighting water from entering surface water or groundwater.
Section 6 – Accidental Release Measures
Person-related precautionary measures: Do not inhale vapours/aerosols. Avoid substance
contact. Ensure supply of fresh air in enclosed rooms.
Environmental-protection measures: Do not allow to enter sewerage system.
Procedures for cleaning / absorption: Take up with liquid-absorbent material. Forward for
disposal. Clean up affected area.
Section 7 – Handling and Storage
Handling: Notes for safe handling: Work under hood . Do not inhale substance. Avoid
generation of vapours/aerosols.
Storage: Tightly closed in a well-ventilated place. Accesible only for authorised persons. At
+15°C to +25°C. Protected from light.
Section 8 – Exposure Controls, Personal Protection
Carcinogenic C 3:owing possible carcinogenic effects for man mutagenic M 3:substance which
cause concern for man owing possible mutagenic effects
Sensitization Sh Danger of sensitization of the skin
Personal protective equipment:
Protective clothing should be selected specifically for the working place, depending on
concentration and quantity of the hazardous substances handled. The resistance of the
protective clothing to chemicals should be ascertained with the respective supplier.
Respiratory protection: required when vapours/aerosols are generated. Filter A-(P3)
Eye protection: required
Hand protection:
In full contact: Glove material: butyl rubber; Layer thickness: 0.7 mm; Breakthrough time: > 480
Min.
In splash contact: Glove material: natural latex; Layer thickness: 0.6 mm; Breakthrough time: >
60 Min.
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Industrial hygiene: Immediately change contaminated clothing. Apply skin- protective barrier
cream. Wash hands and face after working with substance. Under no circumstances eat or
drink at workplace. Work under hood. Do not inhale substance.
Section 9 – Physical and Chemical Properties
Form: liquid
Colour: colourless to brown
Odour: amine-like
pH value: at 36 g/l H2O (20 °C) ~ 8.8
Viscosity dynamic (20 °C): 4.4 mPa*s
Melting poin:t -6.2 °C
Boiling poin:t (1013 hPa) 184 °C
Ignition temperature: 540 °C (DIN 51794)
Flash point: 76 °C (DIN 51758)
Explosion limits:
lower 1.2 Vol%
upper 11 Vol%
Vapour pressure (20 °C): 0.5 hPa
Relative vapour density: 3.22
Density (20 °C): 1.02 g/cm3
Solubility in water (20 °C): 36 g/l
log Pow: 0.90 (experimental)
Section 10 – Stability and Reactivity
Conditions to be avoided: Action of light (decomposition). Strong heating.
Substances to be avoided: alkaline earth metals, alkali metals (generation of hydrogen).
Risk of explosion with: oxidizing agent (i.a. peroxi compounds, perchlorates, perchloric acid,
nitric acid, oxygen), organic nitro compounds, benzene/benzene derivatives.
Exothermic reaction with: semimetallic halides, acids, acetic acid anhydride. Risk of ignition or
formation of inflammable gases or vapors with: fluorine.
Hazardous decomposition products: in the event of fire: See chapter 5.
Further information: Forms explosive mixtures with air on intense heating.
Section 11 – Toxicological Information
Acute toxicity
LC50 (inhalation, rat): 3.3 mg/l /4 h (Lit.).
LD50 (dermal, rabbit): 840 mg/kg (Lit.).
LD50 (oral, rat): 871 mg/kg (Lit.).
Specific symptoms in animal studies:
Eye irritation test (rabbit): Irritations (Lit.).
Skin irritation test (rabbit): No irritation (Lit.).
The literature data available to us do not conform with the labelling prescribed by the
EC. The EC has dossiers which have not been published.
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Subacute to chronic toxicity
The carcinogenic potential requires further clarification.
Possible mutagenic effect in humans. The suspicion is based on proven damage to the
genetic material in the somatic cells of man and animal and requires further clarification.
Bacterial mutagenicity: Ames test: negative. (Lit.)
Further toxicological information
After inhalation of vapours: mucosal irritations. absorption.
After skin contact: Irritations. Danger of skin absorption. Risk of skin sensitization.
After eye contact: Severe irritations, Risk of serious damage to eyes.
After swallowing: mucosal irritations. absorption.
After absorption: nausea, vomiting.
Systemic effects: methaemoglobinaemia with headache, agitation, cardiac dysrhythmia,
dyspnoea. Effect potentiated by: ethanol Irreversible damage possible.
Other notes:
The following applies to aromatic amines in general: systemic effect: methaemoglobinaemia
with headache, cardiac dysrhythmia, drop in blood pressure, dyspnoea, and spasms, principal
symptom: cyanosis (blue discoloration of the blood).
Further data
This substance should be handled with particular care.
Section 12 – Ecological Information
Biodegradation: 93 % /28 d (OECD 301 E).
Readily biodegradable.
Behavior in environmental compartments:
Distribution: log Pow: 0.90 (experimental).
No bioaccumulation is to be expected (log Pow <1).
Highly toxic for aquatic organisms. Hazard for drinking water supplies.
Fish toxicity: Danio rerio LC50: 57.6 mg/l /96 h (OECD 203). Onchorhynchus mykiss LC50: 36.2
mg/l /96h (Lit.).
Daphnia toxicity: Daphnia EC50: 0.17 mg/l /48 h (Lit.).
Algeal toxicity: Desmodesmus subspicatus IC50: 68 mg/l /48 h (Lit.).
Bacterial toxicity: activated sludge EC50: 2500 mg/l /10 min (Lit.).
Further ecologic data:
Do not allow to enter waters, waste water, or soil!
Section 13 – Disposal Considerations
Product: Chemicals must be disposed of in compliance with the respective national
regulations.
Packaging: Centrohem product packaging must be disposed of in compliance with the
Republic of Serbia specific regulations.
Section 14 – Transport Information
Road & Rail ADR, RID
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UN 1547 ANILIN, 6.1, II
Inland waterway ADN, ADNR not tested
Sea IMDG-Code
UN 1547 ANILINE, 6.1, II
Ems F-A S-A
Air CAO, PAX prohibited
UN 1547 ANILINE, 6.1, The transport regulations are cited according to international regulations and in the form
applicable in Republic of Serbia. Possible national deviations in other countries are not
considered.
Section 15 – Regulatory Information
Labelling according to EC Directives
Symbol: T Toxic
N Dangerous for the environment
R-phrases: 23/24/25-40-41-43-48/23/24/25-68-50 Toxic by inhalation, in contact with skin and
if swallowed. Limited evidence of a carcinogenic effect. Risk of serious damage to eyes. May
cause sensitization by skin contact. Toxic: danger of serious damage to health by prolonged
exposure through inhalation, in contact with skin and if swallowed. Possible risks of irreversible
effects. Very toxic to aquatic organisms.
S-phrases: 26-27-36/37/39-45-46-61-63 In case of contact with eyes, rinse immediately with
plenty of water and seek medical advice. Take off immediately all contaminated clothing. Wear
suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel
unwell, seek medical advice immediately (show the label where possible). If swallowed, seek
medical advice immediately and show this container or label. Avoid release to the
environment. Refer to special instructions/Safety data sheets. In case of accident by inhalation:
remove casualty to fresh air and keep at rest.
EC-No.: 200-539-3 EC label
Reduced labelling (1999/45/EC,Art.10,4)
Symbol: T Toxic
N Dangerous for the environment
R-phrases: 23/24/25-40-41-43-48/23/24/25-68 Toxic by inhalation, in contact with skin and if
swallowed. Limited evidence of a carcinogenic effect. Risk of serious damage to eyes. May
cause sensitization by skin contact. Toxic: danger of serious damage to health by prolonged
exposure through inhalation, in contact with skin and if swallowed. Possible risks of irreversible
effects.
S-phrases: 26-36/37/39-45 In case of contact with eyes, rinse immediately with plenty of water
and seek medical advice. Wear suitable protective clothing, gloves and eye/face protection. In
case of accident or if you feel unwell, seek medical advice immediately (show the label where
possible).
Section 16 – Additional Information
The information above is believed to be accurate and represents the best information currently
available to us.
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It characterizes the product with regard to the appropriate safety precautions. It does not
represent a guarantee of the properties of the product.
Users should make their own investigations to determine the suitability of the information for
their particular purposes.
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