Magma TM Advanced Pumping System
TM
Low Shear Sanitary Diaphragm Pump
Keeps your flow moving
For Gentle Pumping Applications In Bioprocessing
Scalable processing within
the Lab Series and beyond
Perfect for both research
and production
Key applications include:
Bioreactor perfusion with
a hollow fiber filter
Liquid transfer
Liquid-liquid mixing
Plug-and-Play design creates an integrated system for advanced applications
Flexible design
optimizes lab space
Lab Series
Product Features
Product Highlights
Low Shear Liquid Handling - Diaphragm pumps are low shear in the manner in which they handle fluid and fluid components.
Certain pumps such as peristaltic pumps and rotary lobe pumps create pressure gradients and pinch points as the liquid flow
is moved though narrow mechanical devices or pinch points. The Magma APS diaphragm pump creates only enough pressure
to push the liquid against back-pressure and eliminates pinch points. This can be important in applications where the liquid
and/or liquid components are shear sensitive.
Smart-StopTM - After pressing the STOP button once, the pump empties the liquid and momentarily vents the air from the
pump head to relieve pressure. This minimizes liquid hold-up in the pump and safely removes air pressure.
Quick-StopTM - Pressing the STOP button two times immediately stops the pump in its current position. It can be useful in
certain applications when you do not want the liquid hold-up to be purged.
Safety Alarms - Process conditions are monitored to detect if the pump is not operating properly and if an alarm condition
occurs, a Quick-Stop is initiated and the alarm light goes on.
Data Output (Basic or Advanced) - Data can be captured by an external computerized system for data collection and process
monitoring.
Monitoring of External Pressure - An external pressure transmitter can be connected to the control system. There are user
definable minimum and maximum notification settings and the control system will compare the settings to the minimum and
maximum pressures since the last time the RUN button was pressed. There is a notification on the display if the running
minimum drops below its setting or the maximum exceeds its setting.
Run Interlock Connection - An external piece of equipment can be connected to the control system to be turned on/off
when the controller switches between the run/stop modes. This could be used in different applications where you want an
external piece of equipment to run or stop in conjunction with the Magma APS system and is active if the stop is initiated by
an alarm condition.
Liquid Detector - In case of improper installation of the diaphragm or a failure condition, liquid entry through the air line to
the pump controller will trigger a Quick-Stop and close a valve in the controller to minimize liquid entry to the controller and
prevent liquid flowing through the controller.
Optional Weight Control System - A scale and a feed pump can be connected to the control system and a minimum and
maximum weight entered into the control system. In the run mode, the feed pump will turn on when the scale reading drops
below the minimum value and will turn off when the value exceeds the maximum.
Alarm Light
Control System
Designed For Easy Use and Plug’n’Play Integration
The system comes with all the cords and hoses so you can be set-up and
running in a matter of minutes. Industry standard connectors are used to
assist with specific integration situations. When power is initiated, the
back-lit LCD display turns on and there are several start-up screens and
then the main screen. At the main screen you can enter the run mode or
the set-up menus. In the run mode there are several views that can be
toggled to view process conditions. The set-up menus are easy to
navigate and allow you to set pump parameters and configure your own
custom advanced pumping system with your interfaced components.
Pump and Diaphragm
Designed For Low Shear and Sterile Processing
Incoming Air
Pressure
Regulator
Retractable
Legs
User Interface For
Setup And Process
Monitoring
Regulators Of Liquid
Flow In And Out Of
The Pump
Quick
Connects
For Air
Universal
Power Input
(100-240 Vac)
Optional Input And Outputs
For Creating Your Own
Advanced Pumping System
Low Shear - Through the air inlet/exhaust sanitary fitting, air from the control system enters to push liquid from the pump and
through the sanitary fitting that is connected to the process fluid. The only pressure generated is from process back-pressure.
After the pump has discharged the liquid, liquid is then drawn into the
pump by vacuum connected to the control system.
Pump
Air Inlet/Exhaust
Pump
Air Inlet/Exhaust
Pump
Air Inlet/Exhaust
Sanitary - The specially designed silicone diaphragm is sealed with an
industry standard Tri-Clover® fitting into the stainless steel pump. It is
designed for quick assembly
and disassembly. All materials
are steam compatible. The
pump and diaphragm are made
of materials that meet industry
guidelines.
Key Applications
Reverse Cross
Flow
Filtration
Flow
Media Container
Filtrate Container
Media Pump
Filtrate Pump
Flow
Flow
Flow
Flow
Pressure
Transducer
The Magma APS in conjunction with a hollow
fiber filter can create a bioreactor perfusion
system. The hollow fiber filter retains the cells in
the bioreactor and the reverse cross flow (RXF)
through the hollow fiber inhibits debris from
fouling the membrane filter surface. In the RXF
mode, the low shear pump minimizes cell
damage and eliminates the use of tubing in a
pump that can rupture and spill vessel contents
during an extended process such as perfusion.
The sanitary design maintains bioreactor sterility.
The weight control system can be used to
maintain the vessel level, the run interlock can
Filter
PERF
FOR ECT
PROD VIRUS
UCTI
O N!
Bioreactor
Pump
Controller
Air Tube
Scale
Sanitary and low shear perfusion with disposable processing options.
shut off the filtrate pump when the system stops to preserve filter
capacity, and the external pressure transmitter can be used to monitor
filter performance.
Low Shear Liquid Transfer
Tank
Tank
Controller
Controller
Air Tube
Air Tube
Pump
Pump
Liquid Flow
Check Valve
Liquid Flow
Check Valve
Check Valve
Check Valve
Air Tube
Liquid Flow
Liquid Flow
Disposable Container
Pump
Disposable Container
Check Valve
Check Valve
Simplex Mode
Duplex Mode
The Magma APS if perfect for both short term or
extended liquid transfer operations where low
shear pumping is required or use of a tubing pump
that can rupture and leak unexpectedly needs to
be avoided. The duplex mode can be used to increase pumping
capacity and prevent intermittent pumping. The run interlock and
external pressure transmitter can be used to customize the Magma APS
for the extensive variety of liquid transfer applications.
Low Shear
Liquid-Liquid Mixing
The Magma APS can be used for low shear mixing
of readily miscible liquids without the use of an
impeller by providing gentle agitation of the
liquid in the process vessel. It can be adapted to
existing tank drains or disposable containers.
With the weight control option, an automated
mixing and dilution system can be created. If
configured properly, the Magma pump can also be
used for transfer of liquid from the vessel after
mixing.
Liquid Flow
Tank
Addition Pump
Disposable Container
Liquid Flow
Scale
Liquid Flow
Drain Valve
Pump
Controller
Air Tube
Liquid Flow
Technical Specifications
Pump:
Material:
Tri-Clamp:
Dimensions:
Diaphragm:
Material:
Regulatory:
316L stainless steel
(electropolish by request)
304 stainless steel
Vary by model number, drawings
available upon request
Molded from platinum cured silicone
in a Class 1000 clean room
- Meets USP Class VI Medical
Grade Specifications
- Meets FDA CFR 177.2600
Standards for contact with food
and drugs
- Meets European Pharmacopoeia
Standards 3.1.9.current revision
Control System:
Enclosure Dimensions (HxWxD):
Enclosure Weight:
Enclosure Material:
Air Pressure Regulator Input:
Output:
Power Requirements:
Run Interlock Connection:
Alarm Output Connection:
External Pressure Input:
Data:
Magma Pump Connection:
Air Connection:
Exhaust Connection:
4.8”x13.8”x10.3” (12.2x35.1x26.3 cm)
10 lbs. (4.5 kg)
Aluminum
125 psi max (8.6 bar)
2-25 psi (0.14 - 1.7 bar)
100-240 Volts, 50-60 Hertz, 2 amp
3 - 48VDC, up to 3A continuous
3 - 48VDC, up to 3A continuous
4-20 milliamp, -14.7 to 30 psi
RS232 communication protocol
CPC MC or LC series
CPC MC series
CPC LC series
Optional:
Feed Pump Connection:
Scale Input:
3 - 48VDC, up to 3A continuous
RS232 communication protocol
Pump Volume & Flow Rates
Magma APS
Model Number
Pump Displacement
(approximate ml)
MAPS-10
Flow Rate Range*
(liters per minute)
10
0.04 - 0.2
MAPS-50
55
0.2 - 1.1
MAPS-180
175
0.7 - 3.5
MAPS-700
680
2.7 - 13.6
now le
availab
* for liquid transfer in simplex mode range is ½ the flow rate listed
Custom Products for Bioreactor
Process Optimization in RXF Mode
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In the
Computer
Main Controller
Controller 1
Pump 1
© 2008 PendoTECH
Controller 2
Pump 2
M-LS1-R1
Controller 3
Pump 3
Controller 4
Pump 4
Is a batch, fed-batch, or perfusion the best
bioreactor process selection? If a perfusion
process is the answer, the best device can
depend on many factors such as the cell line,
the product, media constituents, process
length, eventual process scale, and bioreactor
volume. If a hollow fiber is your b est choice, a
customized Magma APS System can be designed
for small-scale bioreactor process optimization.
The small-scale system can assist you in minimizing
cost such as media and decreasing the project
time line by pr oviding a multiplexed, turnkey
system with advanced features.
Telephone: (+1) 609-802-1262
www.pendotech.com