Job offers
Chemical Cell Biology Group
Funded Post-Doc Position
“EPIGENETIC CONSEQUENCES OF IRON HOMEOSTASIS IN
CANCER STEM CELLS “
The Chemical Cell Biology Group, based at Institut Curie in Paris, is recruiting talented postdoctoral researchers to study the epigenetic regulation of the epithelial-to-mesenchymal
transition mediated by iron in the context of cancer stem cells. This work is based on our recent
discovery that iron homeostasis is up-regulated in cancer stem cells and may act as an EMT
driver. The successful candidate will join a multidisciplinary research environment including cell
biology and chemistry, and will have access to unique tailor-made chemical probes as well as
forefront imaging and DNA sequencing techniques. The candidate is expected to have confirmed
expertise in cell biology. Prior experience in the following fields will be considered in priority:
advanced light microscopy, genome editing, next generation sequencing, cancer stem cells,
chromatin biology and epigenetics. Applicants should send their CV along with a cover letter and
contact details of at least two references to [email protected].
Link to the group website
Selected publications:
Trang Thi Mai, Ahmed Hamaï, Antje Hienzsch, Tatiana Cañeque, Sebastian Müller, Julien Wicinski,
Olivier Cabaud, Christine Leroy, Amandine David, Verónica Acevedo, Akihide Ryo, Christophe
Ginestier, Daniel Birnbaum, Emmanuelle Charafe-Jauffret, Patrice Codogno, Maryam Mehrpour*,
Raphaël Rodriguez*. Salinomycin kills cancer stem cells by sequestering iron in
lysosomes. Nature Chem, DOI: 10.1038/NCHEM.2778 (2017), Highlight in chemical &
engineering news
Emmanouil Zacharioudakis, Poonam Agarwal, Alexandra Bartoli, Nathan Abell, Lavaniya
Kunalingam, Valérie Bergoglio, Blerta Xhemalce, Kyle M. Miller*, Raphaël
Rodriguez*. Chromatin regulates genome targeting with cisplatin. Angew. Chem. Int.
Ed. DOI: 10.1002/anie.201701144R1 (2017)
Sebastian Müller, G. Almouzni*. Centromeric chromatin dynamics during the cell
cycle. Nature Rev. Genet., 18, 192–208 (2017)
Sebastian Müller, Tatiana Cañeque, Veronica Acevedo, R. Rodriguez*. Targeting cancer
stem cells with small molecules. invited for special issue on Wolf prize of Chemistry, Israel J
of Chemistry, DOI: 10.1002/ijch.201600109 (2017)
Nathan S. Abell, Marvin Mercado, Tatiana Cañeque, Raphaël Rodriguez*, Blerta
Xhemalce*. Click quantitative mass spectrometry identifies PIWIL3 as a mechanistic
target of RNA interference activator enoxacin in cancer cells. J. Am. Chem. Soc. 139,
INSTITUT CURIE, 20 rue d’Ulm, 75248 Paris Cedex 05, France | 1
Job offers
Chemical Cell Biology Group
1400-1403 (2017)
Tatiana Cañeque, Filipe Gomes, Trang Thi Mai, Giovanni Maestri, Max Malacria, Raphaël
Rodriguez*. Synthesis of marmycin A and investigation into its cellular
activity. Nature Chem. 7, 744-751 (2015)
Raphaël Rodriguez*, Kyle M. Miller*. Unravelling the genomic targets of small molecules
using high-throughput sequencing. Nature Rev. Genet. 15, 783-796 (2014)
Delphine Larrieu, Sébastien Britton, Mukerrem Demir, Raphaël Rodriguez*, Stephen P.
Jackson*. Chemical inhibition of NAT10 corrects defects of laminopathic cells. Science
344, 527-532 (2014)
INSTITUT CURIE, 20 rue d’Ulm, 75248 Paris Cedex 05, France | 2