Canadian asset Map for steM Cell and regenerative MediCine This publication is also available online in HTML and .pdf formats at www.ic.gc.ca/stemcells This publication is available upon request in accessible formats. Contact: Multimedia Services Section Communications and Marketing Branch Industry Canada Room 441E, East Tower 235 Queen Street Ottawa ON K1A 0H5 Telephone: 613-995-8552 Fax: 613-954-6436 Email: [email protected] Aussi offert en français sous le titre : Carte des ressources canadiennes dans les domaines des cellules souches et de la médecine régénérative Cette publication est disponible en ligne en formats HTML et pdf à www.ic.gc.ca/cellulessouches Release Note: Published by Industry Canada, March 2012. 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Design and Pre-press production by: AN Design Communications Ottawa, ON www.an-design.ca 3 TABLE OF CONTENTS 1 EXECUTIVE SUMMARY 2 2 INTRODUCTION 2.1 Importance of Regenerative Medicine and Stem Cells 2.2 Purpose of the Asset Map 2.3 Description of Stem Cells 4 4 4 5 3 OVERVIEW OF STEM CELL AND REGENERATIVE MEDICINE RESEARCH IN CANADA 3.1 Canada’s Global Position in Stem Cell and Regenerative Medicine Research 3.2 Funding for Stem Cell and Regenerative Medicine Research 3.3 Stem Cell and Regenerative Medicine Research Centres 3.4 Funding and Researchers by University and Province 7 7 8 9 9 4 FOCUS OF STEM CELL AND TISSUE ENGINEERING RESEARCHERS 4.1 Pluripotent Stem Cells 4.2 Tissue-Specific Stem Cells (Somatic) 4.3 Cancer Stem Cells 4.4 Tissue Engineering 13 13 14 15 15 5 DISEASES/CONDITIONS TARGETED BY STEM CELL AND REGENERATIVE MEDICINE RESEARCHERS 5.1 Cancer 5.2 Neurology 5.3 Musculoskeletal 5.4 Cardiovascular 5.5 Metabolic Including Diabetes 5.6 Hematological 5.7 Other 5.8 Translational Medicine 19 19 19 20 20 20 21 21 21 6 RELEVANT SUPPORT FACILITIES 6.1 Biobanks 6.2 Other Relevant Facilities 25 25 25 7 NETWORKS 7.1 National and International Networks 7.2 Provincial Networks 31 31 31 8 KEY RESEARCHERS AND INSTITUTIONS 8.1 Key Researchers 8.2 Key Research Institutions 37 37 39 9 CONCLUSION 46 10 ACKNOWLEDGEMENTS 46 11 CONTACTS 47 iii CANADIAN ASSET MAP FOR STEM CELL AND REGENERATIVE TABLE OF CONTENTSMEDICINE appendiX Appendix 1 Methodology Appendix 2 Interviewees Appendix 3 Lists of Canadian Stem Cells and Regenerative Medicine Researchers 3a. Researchers in Alphabetical Order 3b. Researchers According to Regenerative Medicine Focus 3c. Researchers According to Disease Focus 3d. Examples of Researchers Working in Translational Medicine and/or Clinical Trials iv 48 48 51 52 52 96 117 135 Appendix 4 Research Centres Listed by Province 137 Appendix 5 References and Notes 141 Canadian asset Map for steM Cell and regenerative MediCine Prepared by International BioPharma Solutions Ltd. For the Life Science Industries Branch of Industry Canada CANADIAN ASSET MAP FOR STEM CELL AND REGENERATIVE MEDICINE eXeCutive suMMarY • Regenerative medicine, particularly stem cells, has considerable potential to help in the treatment of numerous common and intractable diseases and conditions • Canada is a leader in stem cell research as these cells were first discovered by Canadian scientists; however, other countries have become more and more important in this field • 68 centres within or affiliated with 25 of Canada’s universities are associated with stem cell and regenerative medicine research • From the sources available for this Asset Map (mainly federal government), more than $277.5 million was spent on stem cell and regenerative medicine research over the last five years (2006/7– 2010/11), with Canadian Institutes of Health Research (CIHR) and Canada Foundation for Innovation (CFI) as the largest funders (providing 36% and 23% of funds, respectively); since the data from these sources perhaps account for only 50%–60% of overall funding, approximately $460 million–$560 million were probably spent on stem cell/ regenerative medicine research • The majority (65%) of funding went to Ontario (ON), particularly the University of Toronto and the University of Ottawa; Québec (QC) received 15%, followed by British Columbia (BC) and Alberta (AB) 2 • • • • (9% each) 416 researchers (in professor, associate professor, or similar positions) were identified as working in the field of stem cells and regenerative medicine research; 47% of these are located in Ontario, 25% in Quebec, 13% in British Columbia and 9% in Alberta In terms of universities, the University of Toronto (or its affiliated institutions) houses by far the greatest number of researchers (26%), followed by the University of British Columbia (UBC) (12%), the University of Ottawa, McGill University, and Université de Montréal Many of the 416 researchers are extremely well regarded, with 81 endowed Chairholders, 69 of whom are Canada Research Chairs (CRCs); 20 researchers have made significant contributions to stem cell research and/or are particularly well funded and/or cited The most important research organizations within or affiliated with the universities in terms of numbers of stem cell and regenerative medicine researchers and endowed Chairs are with the University of Toronto (Ontario Cancer Institute, Sick Kids, McEwen Centre, Sunnybrook), the University of British Columbia (Terry Fox Laboratory), Université Laval (Laboratoire d’organogénèse expérimentale—LOEX), EXECUTIVE SUMMARY • • • • • • • and the University of Ottawa (Sprott Centre) 73% of researchers work with stem cells of some type, while 19% work in tissue engineering; others work in social sciences & humanities, bioprocessing, or various stem cell technologies such as high throughput sorting/analysis or cryopreservation Within the stem cell research area, 54% of researchers work with tissue-specific stem cells, 16% with pluripotent stem cells and 10% with cancer stem cells; another 10% work with a number of stem cell types, with the majority working with both tissue-specific and pluripotent Of the researchers who only work with tissue-specific stem cells, 36% work with hematopoietic, 19% with bone marrow/ mesenchymal and 14% with neural cells Of those who work with pluripotent stem cells, 92% work with embryonic and 20% with induced pluripotent stem cells (some researchers work with both types of pluripotent stem cells) Within the tissue engineering field, at least 65% work with both scaffolds and cells, while 27% work just with biomaterials; the focus of the other researchers was unspecified In terms of disease focus, 25% work in two or more disease areas, 24% work just on cancer, and 14% on neurological, 12% on musculoskeletal, and 10% on cardiovascular conditions Perhaps 100 researchers (24%) are involved in the translation of stem cell research from the laboratory to the clinic, with the Stem Cell Network (SCN) so far devoting approximately $50 million to the funding of translational projects over the past 10 years 1 • Canada has at least 4 public or university cord blood banks, 2 stem cell line banks, and 15 other relevant tissue banks that can be accessed by its regenerative medicine researchers; it also has at least 3 stem cell bioprocessing/manufacturing facilities as well as other relevant shared infrastructure • Canada’s stem cell and regenerative medicine researchers are members of at least 5 international, 6 national, and numerous provincial relevant networks • Overall, Canada remains among the world leaders in stem cell research. 3 CANADIAN ASSET MAP FOR STEM CELL AND REGENERATIVE MEDICINE introduCtion 2.1 Importance of Regenerative Medicine and Stem Cell Regenerative medicine involves the renewal of body tissues or the restoration of organ and tissue function through the use of living cells, particularly stem cells. Stem cells offer a particularly rich source of regenerative technologies as, under the right conditions, they can differentiate into many different cell types (see below). They have considerable potential to help in the treatment of numerous common and intractable diseases and conditions, such as diabetes, arthritis, stroke, renal failure, heart failure, cancer, spinal cord injury, and neurodegenerative diseases, including Parkinson’s and Alzheimer’s. They can also be used in organ regeneration, genetic diseases, and other tissue repair or replacement (e.g., bone and skin transplants, cartilage regeneration). A number of stem cell-based regenerative technologies are used today, such as eye surface stem cells for the treatment of some corneal diseases and injuries; and blood stem cells for treating hematological cancers (e.g. leukemias) and other conditions, such as sickle cell anemia. In fact, bone marrow transplants have become a standard of care for the treatment of certain hematological cancers, while skin stem cells are frequently used 4 in wound healing. However, these clinical uses represent just a small fraction of the opportunities in regenerative medicine and researchers are working furiously to understand the role stem cells may play in other diseases, and to translate these findings into the clinic. To be clinically effective, stem cells need to be delivered to and integrate with the relevant body site. Delivery methods can include gels, films, scaffolds, and targeted carrier technologies that are produced from biomaterials (e.g., polymers, lipids), modified cells or, in the case of some carrier technologies, modified viruses. The combination of stem cells (or other cell types) and a scaffold or similar technology is called tissue engineering. Furthermore, because stem cells occur in highly limited quantities within the body, effective methods are required to mobilize, isolate, culture, and store them. Adequate production methods are essential to unlocking their clinical potential. 2.2 Purpose of the Asset Map Using the methodology described in Appendix 1, this Asset Map provides a snapshot of Canadian stem cell and regenerative medicine research. Since this research sector could potentially be extremely broad-based, we have specifically INTRODUCTION focused on pluripotent, tissue-specific, and cancer stem cell research, biomaterials in terms of scaffolds or similar technologies for use in regenerative medicine, and tissue engineering in terms of production of stem cells and their delivery device. We have not included gene therapy (unless it involves stem cells) or growth factors, xeno-organs, regeneration of plants or animals (unless the studies relate to experimental models of human conditions) or companies working in regenerative medicine. 2.3 Description of Stem Cells This Asset Map distinguishes between three overall types of stem cell. The two major stem cell types are pluripotent and tissuespecific (also known as adult or stromal). The third type of stem cell specifically targeted in this report are cancer stem cells, a type of tissue-specific cell. Pluripotent stem cells have the ability to give rise to all kinds of cell in the body, such as those of the heart, lungs, muscles, skeleton, or brain. These unspecialized stem cells are derived from either embryos or from adult stem cells that have been reprogrammed (or “induced”) to enter an embryonic stem cell–like state. The latter are called induced pluripotent stem cells. 2 capacity for differentiation is usually limited to cell types in the organ of origin.1 So, for example, neural stem cells can become any type of cell in the brain or spinal cord but cannot differentiate into heart cells unless they have been reprogrammed into induced pluripotent stem cells. Cancer stem cells (also known as tumorinitiating cells) are a resilient subset of cells found in tumors with the capacity to self-renew and differentiate. They’ve been identified in many types of solid tumor cancers, including cancer of the breast, head and neck, lung, prostate, pancreas and glioblastoma. Cancer stem cells appear to be preferentially resistant to both standard chemotherapy and radiotherapy. Although cancer stem cells are not part of regenerative medicine (they regenerate cancer tissues thereby destroying normal tissues), they are an important aspect of stem cell research. Tissue-specific stem cells have been identified in many organs and tissues, including brain, bone marrow, peripheral blood, blood vessels, skeletal muscle, skin, teeth, heart, gut, liver, ovarian epithelium, and testis. They are undifferentiated cells that are able to self renew and differentiate. Since their primary role in a living organism is to maintain and repair the tissue in which they are found, their 5 inside 3.1 3.2 3.3 3.4 Canada’s Global Position in Stem Cell and Regenerative Medicine Research Funding for Stem Cell and Regenerative Medicine Research Stem Cell and Regenerative Medicine Research Centres Funding and Researchers by University and Province overvieW of steM Cell and regenerative MediCine researCH in Canada 3.1 Canada’s Global Position in Stem Cell and Regenerative Medicine Research Canada has been a leader in the stem cell research field since Canadian researchers Drs. James Till and Ernest McCulloch of the Princess Margaret Hospital/Ontario Cancer Institute in Toronto first proved the existence of stem cells (hematopoietic) almost 50 years ago.2 For this achievement, they were awarded the 2005 Lasker Prize (often described as America’s “Nobel”).3 Their work has contributed to the development of several lifesaving therapies, such as bone-marrow transplantation to treat cancer. In fact, more than 42,000 people worldwide have been treated using blood stem cells to renew their blood supply.4 Furthermore, through the continued training of researchers in their and their former students’ labs, Canada has continued to make significant contributions in this area:5 • Drs. Janet Rossant and Andras Nagy first proved the inherent pluripotential nature of an embryonic stem cell • Dr. John Dick discovered cancer stem cells • Dr. Sam Weiss was the first to identify neural stem cells in the brain • Dr. Connie Eaves discovered breast stem cells • Dr. Michael Rudnicki identified muscle and cardiac stem cells6 • Dr. Freda Miller demonstrated the existence of stem cells in adult skin tissue • Dr. Derek van der Kooy identified retinal stem cells • Dr. Mick Bhatia developed a process to transform skin cells into stem cells.7 In fact, Canada’s importance in hematopoietic stem cell research up until at least 2000 was illustrated by a Nature Immunology review that found 15 of the 32 most important papers in the field over the 7 CANADIAN ASSET MAP FOR STEM CELL AND REGENERATIVE MEDICINE period from 1960–2000 were authored by Canadians.8 In the field of embryonic stem cell research, Canada ranked second in the number of publications from 1991–2001, and first in both total citations and citations per paper.9 However, in recent years Canada has been slipping in importance, mainly because of a slowdown in comparative research funding. Thus, according to the MaRS Regenerative Medicine 2009 Industry Briefing report,10 in 2009 Canada occupied 4th position in the global rankings of stem cell researching countries after the United States (US), United Kingdom (UK), and South Korea in terms of government funding and 3rd in terms of influential stem cell patents (after the US and UK), although it still had a leading position (1st) in terms of citations. Although the South Korean investments mentioned above have probably declined recently following the bogus cloning research results of Hwang, other governments (e.g., Germany, the EU) and US states have been making significant and growing investments (Drew Lyall [Executive Director, SCN], personal communication). Thus, since 2007, individual US states other than California have promised over $1 billion in stem cell research funding, generally over a 10 year period (e.g., Connecticut $100 million, New Jersey $250 million and New York $600 million),11 while Wisconsin has established a $750 million publicprivate partnership for such research.12 California alone is investing $3 billion in the full spectrum of stem cell research and therapeutic development, from fundamental research to manufacturing facilities to clinical trials and beyond.13 8 3.2 Funding for Stem Cell and Regenerative Medicine Research The majority of funding information was obtained from federal government sources. Funding information was also available on the Terry Fox Foundation (TFF), US National Institutes of Health (NIH), AllerGen, the Ontario Government, and the Saskatchewan Health Research Foundation websites. Dollar figures were not provided on the websites of other provincial governments. Although the SCN breaks down its funds for individual research projects, only total NCE funding for the Network was used in the analysis (see Appendix 1 Methodology). A minimum of $277.5 million from the aforementioned sources was spent on stem cell and regenerative medicine research over the last five years (2006/7–2010/11). As illustrated in Figure 1, CIHR was the largest funder, providing 36% of the funds. The NCE funds, at 10% of the total, were those dedicated to the SCN. Based on the data contained in the BC Regenerative Medicine Asset Map, the aforementioned funders included in this analysis probably account for only 50%–60% of funding in stem cell and biomaterials research for regenerative medicine. Thus, over the last five years, approximately $460 million – $560 million were probably spent on research into these fields. Information contained on the websites of various researchers indicates that other funders include: • • • • • ALS Society of Canada Canadian Cancer Society Canadian Breast Cancer Foundation Christopher Reeve Foundation (US) Heart and Stroke Foundation (of Canada and Ontario) OVERVIEW OF STEM CELL AND REGENERATIVE MEDICINE RESEARCH IN CANADA 3 2% Genome Canada 1% Other* 5% ON Govt 3% NIH (US) 3% NSERC 8% CRC 36% CIHR 9% TFF 10% NCE 23% CFI *Other includes AllerGen, the Saskatchewan Health Research Foundation, and Insception Biosciences Inc. figure 1: Source of Funding for Stem Cell & Regenerative Medicine Research 2006/7 to 2010/11 ($277.5M) • Howard Hughes Medical Institute (US) • Juvenile Diabetes Research Foundation (Canada and US/ International) • Muscular Dystrophy Association (Canada and US) • National Cancer Institute of Canada • SickKids Foundation • US Muscular Dystrophy Association • Various companies (e.g., Roche Foundation for Anemia Research; Bayer) individual research institutes within or affiliated with these universities are also counted (see Appendix 4), then Canada has at least 68 centres where researchers are investigating stem cells and regenerative medicine. Information on the most important of these centres can be found in Section 8. 3.3 Stem Cell and Regenerative Medicine Research Centres As illustrated in Figure 2,14 65% of the $277.5 million in funding went to Ontario (ON). Québec (QC) received 15% followed by British Columbia (BC) and Alberta (AB) (9% each). As listed in Table 1, 25 of Canada’s universities are associated with stem cell and regenerative medicine research. If the 3.4 Funding and Researchers by University and Province 9 CANADIAN ASSET MAP FOR STEM CELL AND REGENERATIVE MEDICINE 2% Other* table 1. Canadian Universities Associated with Stem Cell and Regenerative Medicine Research provinCe 9% AB 9% BC universitY BritisH ColuMBia (BC) Simon Fraser U. U. British Columbia U. Victoria 15% QC alBerta (aB) U. Alberta U. Calgary sasKatCHeWan (sK) 65% ON U. Saskatchewan ManitoBa (MB) *Other includes MB, SK, NB, NS, NL. U. Manitoba ontario (on) figure 2: Total Funding by Province 2006/7 to 2010/11 (Total $277.5M) Carleton U. McMaster U. Queen’s U. U. Guelph U. Toronto $117M U. Ottawa U. Toronto U. Waterloo U. Western Ontario York U. QuÉBeC (QC) École polytechnique de Montréal U. Ottawa $42.8M UBC $23.2M McGill U. McMaster U. $14M U. Montreal U. $25.7M McGill Alberta U. $14.4M $9.7M figure 3: University Funding Over $10M (2006/7 to 2010/11) U. Laval U. Montréal U. Québec à Montréal U. Sherbrooke nova sCotia (ns) Dalhousie U. neW BrunsWiCK (nB) New Brunswick Heart Centre neWfoundland & laBrador (nl) Memorial U. 10 OVERVIEW OF STEM CELL AND REGENERATIVE MEDICINE RESEARCH IN CANADA Associated with the fact that Ontario received the most funding, the University of Toronto received the lion’s share of funds between 2006/7 and 2010/11, at $117 million (Figure 314). All other universities received less than $50 million. Using the definitions stated in section 2.2. and the Methodology (Appendix 1), 416 researchers (in professor, associate professor, or similar positions) were identified as working in the field of stem cells and regenerative medicine research. A list of them can be found in Appendix 3a. Although all these researchers have obtained grants for stem cell and related research and/or mention stem cell and related research on their websites, it should be noted that they often work in additional research areas and stem cells may not be their key focus. 3 Ottawa (8%), McGill University (8%), and Université de Montréal (8%) (Figure 5 and Appendix 4). Information on individual research institutions affiliated with these universities can be found in Section 8. ON 195 QC 102 BC 53 AB 37 A breakdown of the number of researchers working in each province and institution can be found in Appendix 4. The provincial spread of researchers is illustrated in Figure 4. Forty seven percent reside in Ontario, 25% in Quebec, 13% in British Columbia and 9% in AB. In terms of universities, the University of Toronto (or its affiliated institutions) houses by far the greatest number of researchers (26%), followed by the University of British Columbia (12%), the University of SK 5 MB 11 NB 1 NS 11 NL 1 figure 4: Number of Researchers By Province U. Toronto 110 UBC 50 U. McGill U. Laval 23 U. Alberta 16 33 U. Ottawa U. Western Ontario 17 34 U. Montreal McMaster U. 19 32 U. Calgary 21 figure 5: Number of Researchers By University 11 inside 4.1 4.2 4.3 4.4 Pluripotent Stem Cells Tissue-Specific Stem Cells (Somatic) Cancer Stem Cells Tissue Engineering foCus of steM Cell and tissue engineering researCHers Of the 416 researchers working in stem cell and regenerative medicine research, 303 (73%) work with stem cells of some type, while 79 (19%) work in tissue engineering (Figure 6). The others work in social sciences and humanities (n=16), bioprocessing (n=6), various stem cell technologies such as high throughput sorting/analysis or cryopreservation (n=9), or their regenerative medicine research focus was unspecified (n=3). Within the stem cell research area, the majority of researchers (54%, n=166) work with tissue-specific stem cells. Forty nine (16%) investigators work with pluripotent stem cells, while 30 work with cancer stem cells (10%). Another 29 (10%) work with a number of different stem cell types (“various”), with at least 17 working with both tissue-specific and pluripotent (Figure 7). The specific targets of many of these researchers can be found in Appendix 3b. 4.1 Pluripotent Stem Cells As described previously, pluripotent stem cells consist of embryonic and induced pluripotent stem cells. Of the 49 researchers who work only with pluripotent stem cells, the majority focus on embryonic stem cells (84% exclusively, another 12% working with both types, i.e., 96% in total). Similarly with the 17 who work with both pluripotent and tissue-specific cells, 82% focus on embryonic stem cells (65% exclusively, another 17% working with both types). Thus, of all 66 researchers who work with pluripotent stem cells, whether or not exclusively, 92% work with embryonic stem cells. Twenty percent (n=13) of researchers working with pluripotent stem cells work with those that have been induced (four [6%] with induced pluripotent stem cells only, with or without tissue-specific cells; and nine [14%] with both types of pluripotent stem cells, again with or without tissue-specific cells) (Figure 8). Individual researchers working with each group of cells are listed in Appendix 3b. 13 CANADIAN ASSET MAP FOR STEM CELL AND REGENERATIVE MEDICINE 4% Other 4% Social Sciences & Humanities 19% Tissue Engineering 73% Stem Cells figure 6: Percentage of Researchers Working in Each Major Discipline (n=416) 10% Stem Cells: Unspecified (n=29) 10% Stem Cells: Various (n=29) 10% Stem Cells: Cancer (n=30) 16% Stem Cells: Pluripotent (n=49) 54% Stem Cells: Tissue-Specific (n=166) figure 7: Focus of Stem Cell Research (n=303) 4.2 Tissue-Specific Stem Cells (Somatic) The majority of Canadian stem cell researchers work with tissue-specific cells. These can take many different forms as shown in Figure 9. Of the 166 researchers who only work with tissue-specific stem cells, 58 (36%) work 14 with hematopoietic cells. The next most important stem cell types are bone marrow/ mesenchymal and neural cells. Bone marrow contains at least two kinds of stem cells: hematopoietic stem cells that form all types of blood cells and mesenchymal stem cells that can generate bone, cartilage, fat, cells that support the formation of blood, and fibrous connective tissue.15 In most FOCUS OF STEM CELL AND TISSUE ENGINEERING RESEARCHERS 4 2% Unspecific Pluripotent & Tissue-Specific (n=1) 3% Induced Pluripotent & Tissue-Specific (n=2) 5% Both Pluripotent Types & Tissue-Specific (n=3) 3% Induced Pluripotent Only (n=2) 9% Both Pluripotent Types Only (n=6) 17% Embryonic & Tissue-Specific (n=11) 61% Embryonic Only (n=41) figure 8: Focus of Pluripotent Stem Cell Researchers (n=66) cases where a researcher mentioned bone marrow stem cells, the kind of stem cell was not specified. In regard to neural stem cells, these include stem cells derived from the brain, spinal cord, and eye. The category of “other” included the few researchers who were working with the stem cells listed at the end of Figure 9. Two of the researchers working with a number of (“various”) different stem cell types also worked with these rarer stem types. The tissue-specific focus of individual researchers can be found in Appendix 3b. 4.3 Cancer Stem Cells As indicated in Figure 7, 30 researchers are working with cancer stem cells. Among those researchers who are working with several different stem cell types, one is also working with cancer stem cells. Cancer stem cells are an important group of rare cancer cells that have the ability to selfrenew, thereby maintaining and growing cancerous tissue. A list of cancer stem cell researchers can be found in Appendix 3b. 4.4 Tissue Engineering Many of those involved in tissue engineering work with both biomaterials and stem cells. However, some are just involved in developing the biomaterials, particularly scaffolds, that are required to deliver and/or integrate stem cells into a person’s body. Figure 10 gives a breakdown of the research focus of Canada’s 79 tissue engineers working in the field of regenerative medicine that includes stem cells. At least 65% work with both scaffolds and cells, while 27% work just with biomaterials. The focus of each tissue engineering researcher can be found in Appendix 3b. 15 CANADIAN ASSET MAP FOR STEM CELL AND REGENERATIVE MEDICINE 3% Pancreas (n=5) 4% Muscle (n=7) 10% Unspecified Adult (n=17) 36% Hematopoietic, including cord blood (n=58) 14% Other (n=23)* 14% Neutral, including retinal (n=24) 19% Bone Marrow/Mesenchymal (n=32) *Other includes amniotic (n=1), cardiac (n=3), dermal (n=3), fat (n=4), fetal (n=2), gastrointestinal (n=2), germline (n=3), lung (n=1), mammary (n=2 + a researcher who worked with various cell types), ovary (n=1), vascular (n=1). Another researcher who worked with various cell types worked with placental stem cells. figure 9: Focus of Tissue-Specific Stem Cell Researchers (n=166) 16 FOCUS OF STEM CELL AND TISSUE ENGINEERING RESEARCHERS 4 8% Tissue Engineering: Unspecified (n=6) 9% Biomaterials: Scaffolds (n=7) 18% Biomaterials: Unspecified (n=14) 65% Tissue Engineering: Stem Cells and Scaffolds (n=52) figure 10: Focus of Tissue Engineering Researchers (n=79) 17 5.1 5.2 5.3 5.4 5.5 5.6 5.7 5.8 Cancer Neurology Musculoskeletal Cardiovascular Metabolic Including Diabetes Hematological Other Translational Medicine pHoto BY: Craig Aarts, Mammary Epithelial Stem Cell Progeny, Stem Cell Network inside diseases/Conditions targeted BY steM Cell and regenerative MediCine researCHers Of the 416 researchers working in stem cell and regenerative medicine research, 16 are investigating social science and humanities aspects. These individuals have been excluded from the disease analysis. Thus, the data in Figures 11 to 14 refer only to 400 researchers or a subset thereof. The disease focus of each researcher is shown in Appendices 3a and 3c. As indicated in Figure 11, the highest number of researchers (n=101) work in two or more disease areas (designated “various”), such as hematological and cardiovascular, or neurological, urological, and cutaneous conditions. This is particularly true for those who focus on tissue engineering. Some of these individuals are referred to in the subsections below. 5.1 Cancer The most common condition targeted by Canada’s researchers is cancer with 94 working in this area (Figure 11). In addition, two of the nine working in hematological diseases include cancer research, as do nine working in the “various” category. Thus, at least 105 (26%) investigators work in cancer research. As indicated in Figure 12, the most common focus of cancer research is hematological, particularly leukemia. 5.2 Neurology The second most important disease focus is neurological. As well as the 56 individuals almost exclusively focused on such diseases, at least another 10 categorized in the “various” group also work in this area. The most common diseases being investigated by these 66 researchers (who constitute 17% of the 400 total number of researchers) are those of the eye, spinal cord, and multiple 19 CANADIAN ASSET MAP FOR STEM CELL AND REGENERATIVE MEDICINE 2% Hematological (n=9) 3% Metabolic (n=12) 25% Various (n=101) 10% Other (n=38) 10% Cardiovascular (n=41) 12% Musculoskeletal (n=49) 24% Cancer (n=94) 14% Neurological (n=56) figure 11: Disease Focus of Stem Cell and Regenerative Medicine Researchers (n=400) sclerosis (Figure 13). “Other” conditions include ALS (n=2), Parkinson’s (n=2), Alzheimer’s (n=2), Rett’s syndrome (n=1), stroke (n=2), brain or unspecified injury (n=3), neurological development (n=1), and olfactory (n=2). 5.3 Musculoskeletal Figure 11 indicates that 49 investigators are almost exclusively focused on musculoskeletal conditions, including bone, disc, ligament and cartilage formation and/or regeneration and muscular dystrophy. The targeted condition is not specified or involves multiple aspects in 32 cases. An additional eight researchers in the “various” category also work on musculoskeletal conditions, bringing the total to 57 (14% of the 400 total). 20 5.4 Cardiovascular Of the 41 researchers working almost exclusively in cardiovascular research, 23 (56%) are almost entirely focused on the heart. In addition, 16 of those working in several disease areas include cardiovascular conditions among their areas of focus. Thus at least 57 (14% of the 400 total) researchers are working on cardiovascular diseases. 5.5 Metabolic Including Diabetes All 12 people working on metabolic diseases as shown in Figure 11 work on diabetes. In addition, five of the researchers in the “various” category also work on diabetes. Thus 17 (4% of the 400 total) investigators are using stem cells or related tissue engineering to address diabetes. DISEASES/CONDITIONS TARGETED BY STEM CELL AND REGENERATIVE MEDICINE RESEARCHERS 4 2 5 *Other includes one each of colorectal, liver, ovarian and prostate. Other Cervix 4 Breast 6 Brain 37 Hematological 52 Not Specified figure 12: Number of Researchers Working on Cancer (n=105) 5 note that in several cases, two neurological indications were given, hence the total of the bars is more than 66. Multiple Sclerosis 11 Spinal Cord Injury 16 15 Eye Other 25 52 Multiple/Not Specified figure 13: Number of Researchers Working on Neurological Conditions (n=66) 5.6 Hematological Figure 11 shows that nine researchers are working on hematological conditions other than cancer. In addition, five of the researchers working in several disease areas are targeting hematological conditions. Table 2 shows a breakdown of the hematological focus of these 14 researchers. 5.7 Other Figure 14 shows all other disease areas targeted by Canada’s stem cell and regenerative medicine researchers. Those receiving the most attention are immunological conditions (n=6), including allergies, asthma, immunodeficiency, and autoimmune. Five researchers are also working on better understanding embryogenesis, while eight researchers are working on aspects of male and female fertility (“reproduction”). Respiratory conditions, such as cystic fibrosis, or lung development or repair, are the focus of four researchers. All other conditions are targeted by three researchers or fewer. 5.8 Translational Medicine Although the constraints involved in the preparation of this report did not allow for a detailed analysis of researchers that are 21 CANADIAN ASSET MAP FOR STEM CELL AND REGENERATIVE MEDICINE table 2. Number of Researchers Working Within the Hematological Disease Area (excluding Cancer) tYpe of disease nuMBer of researCHers Anemia 5 Hemophilia 4 Unspecified 5 driving translational medicine (moving findings from the laboratory to the clinic), many were noted during the analysis that did take place. Thirty nine of these are listed in Appendix 3d. There is no doubt that many other researchers listed in Appendix 3a are also working to translate the basic stem cell research findings to the clinic, as the SCN indicated that its approximately 100 researchers had spent around $50 million on translational research over the past 10 years (Lyall, personal communication). Furthermore, Canada has a history of clinical innovations with stem cells. For example, clinicians at the University of Alberta published “The Edmonton Protocol” in the New England Journal of Medicine (2000), providing the first proof of principle that Type 1 Diabetes could be treated effectively by using replacement beta cells (in this case from donated pancreases).16 This innovation has spurred researchers to explore the potential of deriving functional beta cells from stem cells. In addition, Canadian clinicians developed the “Halifax Protocol” which is now being used in international clinical trials to treat Parkinson’s disease17. Our researchers are also developing new protocols for multiple sclerosis, graft-versus-host disease, stroke, pulmonary hypertension, neuroblastoma and other diseases that can be addressed with stem cells. 22 DISEASES/CONDITIONS TARGETED BY STEM CELL AND REGENERATIVE MEDICINE RESEARCHERS 1 Aging 1 Cardiopulmonary 3 Cutaneous 3 Dental 5 1 5 Embryogenesis Gastrointestinal 2 Genetic 6 1 Infection 1 Renal 5 3 Reproduction—Female Reproduction—Male 4 2 Immunological Respiratory Urological figure 14: Number of Researchers Working on “Other” Conditions (n=38) 23 inside 6.1 Biobanks 6.2 Other Relevant Facilities relevant support faCilities 6.1 Biobanks 6.1.1 CORD BLOOD BANKS There are two public cord blood banks in Canada: one in Montréal (Héma-Québec Cord Blood Bank) and the other one in Edmonton (Alberta Cord Blood Bank). There are also blood banks at several universities that have samples available for research purposes.18 Furthermore, there are private blood banks in which parents can place their baby’s blood in case of future medical problems. In addition, Canadian Blood Services are trying to establish a national cord blood bank that should be available by 2013.19 The blood banks listed in Table 3 are those that may be accessed for scientific purposes. It should be noted that this list may not be all-inclusive. 6.2 Other Relevant Facilities As well as the biorepositiories, there are lots of other facilities that may be relevant to stem cell researchers. These include at least three manufacturing/bioprocessing facilities as well as the other centres listed in Table 5. 6.1.2 OTHER BIOBANKS Other biobanks include those with tissue samples (generally from cancer patients) or pluripotent stem cell lines (both embryonic and induced pluripotent) available for research purposes. Table 4 lists some of those available in Canada. Again, this list is probably not all-inclusive but includes two stem cell line banks and 15 other tissue banks. Other potential biobanks are in the planning stage, e.g., a brain tumour tissue bank in Vancouver.20 25 CANADIAN ASSET MAP FOR STEM CELL AND REGENERATIVE MEDICINE table 3. Publicly-Available Cord Blood Banks Blood BanK Managed BY url Alberta Cord Blood Bank U. Alberta www.acbb.ca Banque publique de sang de cordon du Québec Héma-Québec www.hema-quebec.qc.ca/donner/cellules-souches/don-desang-de-cordon-ombilical/index.fr.html Registre des donneurs de cellules souches (moelle osseuse) Héma-Québec www.hema-quebec.qc.ca/donner/cellules-souches/registredes-donneurs/index.fr.html Clinical-Research Cord Blood Bank of the McGill University Health Centre McGill University Health Centre muhc.ca/research/page/core-facilities Toronto Cord Blood Program Inseption Biosciences, Mount Sinai Hospital www.insception.com table 4. Other Biobanks Available to Researchers BioBanK loCation inforMation url Braley Human Stem Cell Library (HSCL) Stem Cell and Cancer Research Institute (SCC-RI), Hamilton, ON Has more than 15 iPS cell lines for use in regenerative medicine research. fhs.mcmaster.ca/ SCCRI/21 National Registry for Human Embryonic Stem Cell Lines Administered by CIHR22 A list of all human embryonic stem cell lines derived under the auspices of an Institution that receives Canadian Agency funds. Includes 4 cell lines (2 each in Toronto and Calgary). www.cihr-irsc. gc.ca/e/39580.html Brain Tumour Tissue Bank Lawson Research Institute, London, ON Collects and provides human brain tumour specimens and matching clinical data for neuro-oncology research in Canada and internationally. www.lawsonresearch. com/clinical_research/ brain_tumour_bank.htm Breast Tumour Bank BC Cancer Research Centre, Vancouver, BC This BC Cancer Agency’s breast cancer tumour tissue repository (BREAST-TTR) comprises several important banks of breast tissues, contemporaneous as well as archival. molonc.bccrc.ca/?page_ id=421 Canadian Breast Cancer Foundation (CBCF) Tumor Bank Cross Cancer Institute, Edmonton; Tom Baker Cancer Centre, Calgary; U. of Calgary; all in AB Collaboration between CBCF—Prairies/NWT Chapter and the Alberta Health Services, providing a comprehensive collection of cancer specimens with related clinical information for use by researchers. www.abtumorbank.com Canadian Virtual Brain Tumour Bank Toronto Western Hospital, Toronto, ON Acts as a resource for researchers to provide them with information on the types of brain tumour tissue samples available and direct them to the tumour tissue banking sites holding these samples. www.braintumourbank. ca steM Cell lines otHer BioBanKs 26 RELEVANT SUPPORT FACILITIES BioBanK loCation inforMation url Manitoba Breast Tumor Bank Cancer Care Manitoba, Winnipeg, MB Provides anonymized, processed, and annotated cancer tissues and data for translational research. www.umanitoba.ca/ institutes/manitoba_ institute_cell_biology/ MBTB/Index4.htm Maritime Brain Tissue Bank Dalhousie U., NS Collects brain tissues and makes them available for researchers who are trying to better understand the causes of dementia. research.medicine.dal. ca/cores-brain.htm National Cancer Institute of Canada Clinical Trials Group (NCIC CTG) Tissue Bank Queen’s U., Kingston, ON Contains unique disease specific collections, housed, catalogued, and linked to an associated clinical dataset to support correlative science. www.ctg.queensu.ca/ TissueBank/index.html Ontario Tumour Bank Ontario Institute for Cancer Research, Toronto, ON Focused on collection of tumour-related human biospecimens for use by academic and industry cancer researchers. www.ontariotumourbank. ca OvCaRe Gynaecologic Tissue Bank Vancouver General Hospital and BC Cancer Agency, Vancouver, BC Contains tumour and serum samples from over 1,100 consenting patients. In addition to providing research material for OvCaRe researchers, the Tumour Bank has contributed to 43 national and international research projects. ovcare.ca/research/ platforms.php PROCURE Québec Prostate Cancer Biobank Mont-Royal, QC Collects and stores standardized high volumes of prostatic tissues, blood, urine, clinical information and socio-demographic data from men undergoing prostate cancer screening and surgery across QC and facilitates access to these resources. www.procure. ca/tiki-index. php?page=biobank_ overview_introduction Québec Leukemia Cell Bank Centre de recherche de l’Hôpital Maisonneuve-Rosemont, Montréal, QC Supports basic and clinical blood cancer research; provides an infrastructure and services aimed at facilitating the work of researchers in various fields, such as oncology, hematology and immunology. www.bclq.org/en/index. html Le Réseau de recherche sur le cancer du Fonds de la recherche en santé du Québec (RRCancerFRSQ Network) Montréal, QC Provides tumour banks and other resources to Québec researchers. www.rrcancer.ca Tumour Bank Sunnybrook Research Institute, Toronto, ON Collects, stores, and distributes tissues for the following body sites: breast, prostate, colorectal, gynecological. sunnybrook.ca/research/ content/?page=sri_core_ tbank_home Tumour Tissue Repository BC Cancer Agency, The Deeley Research Centre, Victoria, BC Collects anonymized and appropriately consented biospecimens (tissues and blood) and associated clinical information for use by cancer translational researchers throughout Canada and worldwide. www.bccrc.ca/dept/ttr Vancouver Prostate Centre Biorepository Vancouver Prostate Centre, Vancouver, BC Contains over 2,000 prostate cancer specimens (both fresh frozen and paraffin embedded), as well as an integrated database. www.prostatecentre. com/our-research/corefacilities/biorepository 6 27 CANADIAN ASSET MAP FOR STEM CELL AND REGENERATIVE MEDICINE table 5. Support Facilities for Stem Cell and Regenerative Medicine Research 28 naMe desCription url Biotechnology and Pharmaceutical Processes Research Unit, École polytechnique de Montréal, QC Develops bioprocesses to produce and purify high quality, valuable biomolecules. www.polymtl.ca/bio-p2/ Centre de Recherche de l’Hôpital Maisonneuve-Rosemont, Montreal, QC As well as the Québec Leukemia Cell Bank described in Table 4 and the CECT described below, the Centre de Recherche de l’Hôpital Maisonneuve-Rosemont also offers other relevant research facilities such as flow cytometry and an animal supply facility. recherche.maisonneuverosemont.org/en-ca/research/ technical-support-programs/ flow-cytometry.html Centre for Applied Genomics (TCAG), Hospital for Sick Children (Sick Kids), MaRS Centre, Toronto, ON Provides project support to investigators, including laboratory experimentation, statistical analysis and bioinformatics support. It also has a Biobanking and Databasing Facility that provides DNA extraction from lymphoblasts, fibroblasts and other cell types, archiving of white cell pellets, preparation and immortalization of cell lines, and comprehensive databasing and tracking of samples and/or cell lines within the facility. www.tcag.ca Centre of Excellence for Cellular Therapy (CECT), Centre de Recherche de l’Hôpital Maisonneuve-Rosemont, Montreal, QC Opening in 2011, CECT will conduct leading-edge research on stem cells, the immune system and cancer; train young researchers; and bring together basic and clinical research. It will offer bioreactors, a high speed cell sorter, FACS analyzer, a level BSCL2 facility, and other state-of-the-art equipment. recherche.maisonneuverosemont.org/en-ca/research/ research-units/centre-ofexcellence-for-cellular-therapy. html LOEX (Experimental Organogenesis Laboratory—Laboratoire d’organogénèse expérimentale), U. Laval. QC Works with epidermal culture and a self-assembly approach to tissue engineering. Activities cover four major areas: (1) Stem cells, differentiation and cellular interactions; (2) Cutaneous, cardiovascular, orthopedic, ophthalmologic, pulmonary and urinary tissue reconstruction; (3) Biological applications of reconstructed tissues (physiology, pathophysiology, pharmacology, toxicology, transplantation) and pre-clinical trials; (4) Clinical applications of cellular and tissue-based therapies. www.cha.quebec.qc.ca/en/ www/research/fields-ofresearch/tissue-engineeringand-regeneration/index.html; www.loex.qc.ca/recherche. interets.php?langue=2 Ottawa Hospital Research Institute (OHRI), Ottawa, ON With 230,000 square feet of dedicated basic and clinical research space, the OHRI houses good manufacturing practice laboratories, advanced imaging equipment, flow cytometry facilities, a clinical pharmacokinetics laboratory and other facilities. As a member of the Shared Core Facilities Initiative, OHRI makes many of its facilities available to the broader academic health research community in Ottawa. www.ohri.ca/About/Facilities. asp Pharmaceutical Production Research Facility, Calgary, AB Commercializing media development and bioreactor protocols for the expansion of mammalian neural stem cells, as well as developing expansion protocols for pancreatic endocrine tissue and progenitor cells, mesenchymal stem cells, hepatic oval stem cells, embryonic stem cells and mammary stem cells. www.pprf.ca Philip S. Orsino Cell Therapy Facility, Princess Margaret Hospital, Toronto, ON23 A state-of-the-art facility offering Good Manufacturing Practice (GMP) grade cell and tissue processing capabilities. www.uhnres.utoroto.ca/ facilities/psoctf/ RELEVANT SUPPORT FACILITIES naMe desCription url Ontario Human Induced Pluripotent Stem Cell Facility, MaRS Centre, Toronto, ON Develops best practices in the technologies of reprogramming with a focus on the establishment and banking of patientspecific primary fibroblast cell lines, and the subsequent generation and characterization of iPS cells. www.ontarioips.ca StemBase, Ottawa Health Research Institute, ON The largest stem cell gene expression database in the world containing information on genomic and proteomic analysis of stem cells. www.stembase.ca Toronto Centre for Phenogenomics, Mount Sinai Hospital, Toronto, ON Conducts and supports genetic research involving generation of mutant mice, physiological phenotyping, behavioural analysis, imaging, pathology and cryopreservation for storage and distribution. Services include generation of novel ES cell lines, and expansion of ES cell clones. www.phenogenomics.ca 6 29 7.1 National and International Networks 7.2 Provincial Networks pHoto BY: Shaalee Dworski, Skin-derived precursors differentiated into Schwann cells, Stem Cell Network inside netWorKs 7.1 National and International Networks Canada’s stem cell and regenerative medicine researchers are members of a number of different relevant national and international networks. These include those networks described in Table 6. Unless otherwise indicated, the description information has been sourced from the URL listed in the table. 7.2 Provincial Networks There are also a number of provincial research networks to which researchers belong. These include those listed in Table 7.27 31 CANADIAN ASSET MAP FOR STEM CELL AND REGENERATIVE MEDICINE table 6. National and International Stem Cell and Regenerative Medicine Networks naMe desCription url Stem Cell Network (SCN) Headquartered at U. Ottawa, ON, this federal government-funded Network of Centers of Excellence (NCE) was formed in 2001 and currently includes 96 researchers and 167 industry, public service and academic partners. It is a catalyst for enabling translation of stem cell research into clinical applications, commercial products or public policy. It will receive $63.62M in federal government funding between 2001 & 2012. www.stemcellnetwork.ca Centre for Commercialization of Regenerative Medicine (CCRM) This federal government-funded Centre of Excellence for Commercialization and Research (CECR) was established at the end of 2010 at U. Toronto, ON. It aims to accelerate the commercialization of regenerative medicine technologies by bringing together business leadership and innovative stem cell and biomaterial technology development. It will receive $15M in federal government funding between 2011 and 2015.24 www.ccrm.ca AllerGen NCE Inc. Allergy and asthma research federal government-funded NCE headquartered at McMaster U., ON. Formed in 2004, it funds some stem cell research in asthma and inflammatory disease. www.allergen-nce.ca C17 Council Organization composed of the institutionally appointed heads of the 16 pediatric hematology, oncology, and stem cell transplantation programs in Canada. Acts as an authoritative Canadian voice representing the interests of children and adolescents with cancer and blood disorders. www.c17.ca Canadian Blood & Marrow Transplant (BMT) Group National, voluntary, multi-disciplinary organization providing leadership and promoting excellence in patient care, research and education in the field of blood and marrow transplantation. www.cbmtg.org Canadian Tumour Repository Network (CTRNet) A translational cancer research resource, funded by CIHR, that furthers Canadian health research by linking cancer researchers with provincial tumour banks. www.ctrnet.ca Cancer Stem Cell Consortium (CSCC) Founded in 2007 by a group of Canadian funding agencies (CFI, CIHR, Genome Canada, Ontario Institute for Cancer Research, Stem Cell Network) to support international collaboration on research on cancer stem cells. Currently has a strategic partnership with the California Institute for Regenerative Medicine. Aims to secure and manage an estimated $500M in research funds during an initial 5-year period (2009–2014).25 www. cancerstemcellconsortium.ca International Consortium of Stem Cell Networks HQ in Ottawa, ON. Consists of 18 stem cell networks from more than 10 countries; currently chaired by Dr. Michael Rudnicki, Scientific Director of Canada’s Stem Cell Network. www.stemcellconsortium.org International Society for Cellular Therapy A global association driving the translation of scientific research to deliver innovative cellular therapies to patients that was established in 1992. Dr. Armand Keating is on the Mesenchymal and Tissue Stem Cells Committee. www.celltherapysociety.org International Society of Stem Cell Research An independent, nonprofit organization formed to foster the international exchange of information on stem cell research between the world’s leading stem cell scientists and researchers. HQ in Deerfield, Illinois, US. Drs. Connie Eaves and Derek van der Kooy are on the Board of Directors. Dr. Gordon Keller is a member of the Global Advisory Council. www.isscr.org national international 32 NETWORKS naMe desCription url International Stem Cell Forum Consists of 14 leading funders of stem cell research from 13 countries. Founded in January 2003 to encourage international collaboration and funding support for stem cell research. Canada’s member is CIHR.26 N/A Pediatric Bone and Marrow Transplant Consortium (PBMTC) A voluntary group of clinicians and scientists that includes over 100 pediatric PBMTC centers in Canada, US, Australia and New Zealand. Purpose is to engage in scientific and educational activities related to the use of hematopoietic stem cells in the treatment of diseases of children and adolescents. Canadian members include Alberta Children’s Hospital, BC Children’s Hospital, Cancer Care Manitoba, Centre Hospitalier Universitaire Ste Justine Chu Ste-Justine, McGill University Health Center— Montreal Children’s Hospital, and Sick Kids. www.pbmtc.org 7 33 CANADIAN ASSET MAP FOR STEM CELL AND REGENERATIVE MEDICINE table 7. Provincial Networks for Stem cell and Regenerative Medicine Researchers naMe reaCH url BC Network for Aging Research British Columbia www.bcnar.ca Child & Youth Health Research Network British Columbia www.cyhrnet.ca BC Clinical Genomics Network British Columbia www.bccgn.ca BC Preclinical Research Consortium British Columbia www.bcprc.ca BC Biolibrary British Columbia www.bcbiolibrary.icapture.ubc.ca BC Proteomics Network British Columbia www.bcproteomicsnetwork.ca British Columbia Pancreatic Cancer Research Net British Columbia www.bccancer.bc.ca/RES/ResearchPrograms/bcpcr/ default.htm Brain Research Centre British Columbia www.brain.ubc.ca ICORD (International Collaboration On Repair Discoveries) British Columbia icord.org Centre for Lymphoid Cancer British Columbia www.bccancer.bc.ca/RES/ResearchPrograms/ LymphoidCancers/default.htm Alberta www.albertahealthservices.ca/services. asp?pid=service&rid=1715 U. Saskatchewan www.medicine.usask.ca/research/health-researchgroups/airways-research-group/index.html Manitoba Neuroscience Network Manitoba www.sbrc.ca/mnn/ Spinal Cord Research Centre U. Manitoba www.scrc.umanitoba.ca/SCRC/About.html Medical Genetics Research Group Manitoba www.umanitoba.ca/faculties/medicine/units/biochem/ research/genetics.html Health Services Research Network (cancer research) Ontario www.oicr.on.ca/newsreleases/2010/Backgrounder_ Health_Services_Research_July122010.pdf Imaging Network Ontario Ontario sunnybrook.ca/research/content/?page=sri_proj_imno_ home Ontario Cancer Genetics Network Ontario www.cancercare.on.ca/cms/one.aspx?pageId=10051 Ontario Stem Cell Initiative (virtual network of over 60 stem cell scientists in Ontario) Ontario www.ontariostemcell.ca Ontario Translational Research Network (cancer research) Ontario www.otrn.ca Network for Oral and Bone Health Research Québec www.rsbo.ca Vision Research Network Québec www.visionnetwork.ca BritisH ColuMBia alBerta Joint Injury and Arthritis Research Group sasKatCHeWan Airways Research Group ManitoBa ontario QuÉBeC 34 NETWORKS naMe reaCH url Cancer Research Network Québec www.rrcancer.ca Réseau de thérapie cellulaire et tissulaire (ThéCell) Québec www.reseauthecell.qc.ca Groupe de recherche en sciences et technologies biomédicales (GRSTB) Institut de génie biomédical of École polytechnique Montréal www.polymtl.ca/recherche/rc/unites/details. php?NoUnite=42 Groupe de recherche sur le système nerveux central Faculty of Medicine of Université de Montréal www.grsnc.umontreal.ca Montréal Diabetes Research Center Montréal Institutions www.montreal-diabetes-research-center.org/en/index.asp Atlantic Path Research Network (cancer research) Nova Scotia, New Brunswick, Prince Edward Island, Newfoundland and Labrador atlanticpath.ca/research/research.html New Brunswick Cancer Network New Brunswick www.gnb.ca/0051/cancer/index-e.asp 7 MaritiMe provinCes 35 inside 8.1 Key Researchers 8.2 Key Research Institutions KeY researCHers and institutions 8.1 Key Researchers There are several ways to measure the importance of a researcher, including: • • • • • • Key contributions Amount of research funding received Position within key research institutes Endowed Chair Number of publications Number of citations. Each of the six criteria metrics provides different outcomes, as described below, but the 21 researchers listed in Table 8 all score high on key contributions and/ or levels of research funding ($5 million or greater used as excellence level). Three researchers score high on all criteria, while at least eight other researchers score high on a minimum of four of the six criteria (from the information that was available for this project; publication, citation, and contributions data are missing for a number of researchers): • Mick Bhatia, McMaster University— scores high on all six criteria • John Dick, University of Toronto—scores high on all six criteria • Janet Rossant, University of Toronto— scores high on all six criteria • Connie Eaves—scores high on four criteria • Keith Humphries—scores high on four criteria • Armand Keating, University of Toronto— scores high on five criteria • Gordon Keller—scores high on four criteria • Freda Miller—scores high on four criteria • Andras Nagy, University of Toronto— scores high on five criteria • Michael Rudnicki, University of Ottawa— scores high on four criteria • Guy Sauvageau, Université de Montréal— scores high on four criteria. In terms of amount of funding received within the constraints of the methodology used in this Asset Map (see Appendix 1), 51 of the 416 researchers received funding of more than $1 million over a five year period (2006/7 to 2010/11). The 13 who received funding of over $5 million are all listed in Table 8, as are two researchers who have recently received over $5 million of funding for use over the next five years from either the Ontario Government (Greenblatt) or Networks of Centres of 37 CANADIAN ASSET MAP FOR STEM CELL AND REGENERATIVE MEDICINE Excellence (NCE) (Zandstra). Thirteen of the 21 key researchers are directors of or hold similar positions within their research institutions and 11 of these received funding of over $5 million. As mentioned above, another way of measuring a researcher’s importance is whether or not (s)he holds an endowed Chair. Eighty one of the 416 researchers are Chairholders, 69 of whom are Canada Research Chairs (CRCs). The latter are high level research professorships created by the Canadian Government to attract and retain some of the world’s most accomplished and promising minds. Eleven Chairholders who have made significant achievements in stem cell/regenerative medicine research and/or received high levels of funding (over $5 million) are shown in Table 8 while the rest are listed in Appendix 3a. Furthermore, using data from Scopus (www.scopus.com), Industry Canada’s Life table 8. Researchers Who Have Made or Are Making Significant Contributions to Stem Cell Research researCHer Bhatia, 38 Mickc researCH institution and position universitY affiliation endoWed CHair Director and Senior Scientist, Stem Cell and Cancer Research Institute McMaster U., ON CRC in Human Stem Cell Biology; Krembil Chair in Stem Cell Biology Dick, John Director, Program in Cancer Stem Cells—Genesis, Ontario Institute for Cancer Research U. Toronto, ON CRC in Stem Cell Biology Dirks, Peter Scientist & Principal Investigator, Hospital for Sick Children (Sick Kids) U. Toronto Eaves, Connie Director, Co-founder, and Senior Scientist, Terry Fox Laboratory; VP Research BC Cancer Agency UBC, BC Greenblatt, Jack Principal Investigator, The Donnelly Centre, Banting and Best Department of Medical Research U. Toronto, ON Humphries, Keith Director & Distinguished Scientist, Terry Fox Laboratory, BC Cancer Agency UBC, BC Keating, Armand Director, Cell Therapy Program and the Orsino Cell Therapy Translational Research Lab., Princess Margaret Hospital U. Toronto, ON Epstein Chair in Cell Therapy & Transplantation Keller, Gordon Director, McEwen Centre for Regenerative Medicine and Senior Scientist, Ontario Cancer Institute U. Toronto, ON CRC in Embryonic Stem Cell Biology Korbutt, Gregory Director, Human Islet Quality Control Laboratory, Alberta Diabetes Institute U. Alberta, AB Miller, Freda Senior Scientist, Developmental & Stem Cell Biology program, Hospital for Sick Children (Sick Kids) U. Toronto, ON CRC in Developmental Neurobiology Nagy, Andrasd Senior Investigator, Samuel Lunenfeld Research Institute, Mount Sinai Hospital and Investigator, McEwen Centre for Regenerative Medicine U. Toronto, ON CRC in Stem Cells and Regeneration Paige, Christopher VP Research, Ontario Cancer Institute U. Toronto, ON KEY RESEARCHERS AND INSTITUTIONS Science Industries Branch and ScienceMetrix on publications and citations,28 at least nine of the 21 researchers had a significant number of publications and citations. The majority of the other researchers probably also had numerous well-cited publications but the data for these could not be collected for this report. 8.2 Key Research Institutions As with researchers, there are several ways of measuring institutional importance, including: • • • • 8 Amount of funding received Number of researchers Number of endowed Chairs Number of publications and citations. These criteria metrics give slightly different results in terms of key institutions. As indicated in section 3.3 and Table 1, 25 of Canada’s universities are associated with stem cell and regenerative medicine research. Associated with the fact that Ontario received 65% of funding (Figure 2 funding BetWeen 2006/07 & 2010/11a # puBs. 2005–2010b Citation indeX (H-indeX)b KeY ContriButions (froM info. supplied BY industrY Canada onlY, unless otHerWise indiCated) $5M+ 22 13 Developed a process to transform skin cells into stem cells.29 $5M+ 18 13 Isolated the first cancer stem cell, in acute myeloid leukemia (1994), and subsequent ones in other tumors. < $1M N/A N/A Isolated and characterized cancer stem cells from human brain tumours of different phenotypes that express neural stem cell markers and have stem celllike behaviour in vitro and in vivo. $1M–$2.5M 30 14 Pioneering research in basic blood stem cell biology. Discovered breast stem cells. Developed stem cell assays. $1M–$2.5M N/A N/A A $5.27M grant for 2011–2014 from the Ontario Government for Protein Complexes in the Epigenetics of Human Disease and Stem Cell Fate research. $5M+ 15 8 N/A $5M+ 33 12 N/A $5M+ N/A N/A Demonstrated that human heart progenitor cells could be grown from embryonic stem cells (2008).30 $5M+ N/A N/A N/A $4M–$5M 16 11 Demonstrated the existence of stem cells in adult skin tissue, and that they could be used to grow nerve cells that could potentially help people with spinal cord injuries or Parkinson’s disease. $5M+ 18 8 Reconstituted a mouse from a single embryonic stem cell, thus proving the cells’ inherent and defining characteristic of pluripotency.31 Established Canada’s first—and to date only—human embryonic stem cell lines (2005). Developed method to create induced pluropotent stem cells (iPS) cells without the use of retroviruses (2009). $5M+ N/A N/A N/A 39 CANADIAN ASSET MAP FOR STEM CELL AND REGENERATIVE MEDICINE table 8. cont’d researCHer researCH institution and position universitY affiliation endoWed CHair Rossant, Janet Chief of Research, Hospital for Sick Children (Sick Kids) U. Toronto, ON Lombard Insurance Chair Rudnicki, Michael Director and Senior Scientist, Sprott Centre for Stem Cell Research (also Scientific Director, Stem Cell Network) U. Ottawa CRC in Molecular Genetics Sauvageau, Guy Chief Executive Officer and founding Scientific Director, Institute for Research in Immunology and Cancer U. Montréal, QC CRC in the Molecular Genetics of Stem Cells Sefton, Michael Principal Investigator, Donnelly Centre for Cellular and Biomolecular Research U. Toronto, ON Michael E. Charles Chair in Chemical Engineering Till, Jim Senior Scientist, Ontario Cancer Institute U. Toronto, ON van der Kooy, Derek Professor, Department of Medical Genetics and Microbiology U. Toronto, ON Weisel, Richard Director, Toronto General Research Institute U. Toronto, ON Weiss, Samuel Director, Hotchkiss Brain Institute U. Calgary, AB Zandstra, Peter McEwen Centre for Regenerative Medicine, University Health Network and Institute of Biomaterials and Biomedical Engineering, Donnelly Centre U. Toronto, ON CRC in Stem Cell Bioengineering Funding (principally federal) collected according to Methodology described in Appendix 1—includes individual investigator funds from Stem Cell Network. Only publication and citation data supplied within an internal document provided by Industry Canada’s Life Science Industries Branch were used here—see above text for reference. c Also has a 2011–2014 grant from the Ontario Government of $9.2M for the Ontario Consortium for Regeneration Inducing Therapeutics (OCRiT). d Also has a 2011–2014 grant from the Ontario Government of $7.25M for a project titled: Molecular pathways of reprogramming—from discovery to novel therapeutics. a b 40 KEY RESEARCHERS AND INSTITUTIONS funding BetWeen 2006/07 & 2010/11a # puBs. 2005–2010b Citation indeX (H-indeX)b $5M+ 25 11 Reconstituted a mouse from a single embryonic stem cell, thus proving the cells’ inherent and defining characteristic of pluripotency.32 $5M+ N/A N/A Discovered adult muscle stem cells. $5M+ N/A N/A Developed the use of recombinant proteins allowing for the expansion of the hematopoietic stem cells. $5M+ N/A N/A N/A Semi-retired N/A N/A Demonstrated the existence of stem cells (1961). $2.5M–$4M 16 10 Identified retinal stem cells in mice (1994). Identified retinal stem cells in the human eye (2000). $5M+ N/A N/A N/A $1M–$2.5M N/A N/A Identified stem cells in the adult human brain (1992)—discovered a mammalian central nervous system (CNS) stem cell. < $1M N/A N/A $15M from 2011 for an NCE CECR: Centre for Commercialization of Regenerative Medicine. 8 KeY ContriButions (froM info. supplied BY industrY Canada onlY, unless otHerWise indiCated) 41 CANADIAN ASSET MAP FOR STEM CELL AND REGENERATIVE MEDICINE above), the University of Toronto received the lion’s share of funds between 2006/7 and 2010/11, at $117 million (see Figure 3 above). This was followed by the University of Ottawa and Université de Montréal. In terms of researchers, the order of importance of the universities changes somewhat. The University of Toronto remains the most important, followed by the University of British Columbia, the University of Ottawa, McGill University, and Université de Montréal (see Figure 5 above, Table 9 and Appendix 4). The University of Toronto has the most endowed Chairs although there is a higher percentage of Chairs as a ratio of researchers at many of the other universities with more than 10 relevant investigators. On this measure, Université de Montréal comes first (Table 9). Within or affiliated with the universities are key research organizations, listed in Appendix 4. The seven largest of these in terms of numbers of stem cell and regenerative medicine researchers are described in Table 10. Four are affiliated with the University of Toronto (in order of researcher numbers: Ontario Cancer Institute, Sick Kids, McEwen Centre, Sunnybrook) and one of each is affiliated with the University of British Columbia (Terry Fox Laboratory), Université Laval (LOEX), and the University of Ottawa (Sprott Centre). All have endowed Chairs, with the most residing at McEwen (n=6), Sprott (n=5), and Sick Kids (n=4). Table 11 lists 10 other research institutes that each house five or more investigators: three affiliated with the University of British Columbia, two with the University of Toronto, and one each with the University 42 of Calgary, McMaster University, the University of Ottawa, McGill University and Université de Montréal. In addition, although housing fewer than five researchers (by this report’s analysis), the Institute of Cell Biology at the University of Manitoba is also considered to be a key institution by interviewees. In terms of publications and citations, data from Industry Canada33 showed that between 1996 and 2009, Canada published over 1,050 regenerative medicine research papers. Overall, Canadian papers in regenerative medicine were cited 30% more often than the world average as indicated in Table 10 for our key universities: the University of Toronto, McGill University, and the University of British Columbia, as well as the University of Alberta, the University of Calgary, and McMaster University. KEY RESEARCHERS AND INSTITUTIONS 8 table 9. Stem Cell and Regenerative Medicine Researchers and Endowed Chairs by University provinCe universitY # relevant researCHers # relevant endoWed CHairs (% of researCHers) # puBs/ sCi. iMpaCt * ranK BY researCHer # U. Alberta 16 4 (25%) 116/1.7 10 U. Calgary 21 1 (5%) 60/1.6 7 SFU 1 0 N/A 21 joint UBC 50 7 (14%) 121/1.3 2 U. Victoria 2 1 (50%) N/A 19 U. Manitoba 11 2 (18%) N/A 11 1 0 N/A 21 joint Memorial U. 1 0 N/A 21 joint Dalhousie U. 11 1 (9%) N/A 12 Carleton U. 1 0 N/A 21 joint McMaster U. 19 5 (26%) 75/1.1 8 Queen’s U. 9 1 (11%) N/A 13 U. Guelph 1 0 N/A 21 joint U. Ottawa 34 9 (26%) N/A 3 U. Toronto 110 24 (22%) 173/1.5 1 U. Waterloo 3 0 N/A 18 U. Western Ontario 17 1 (6%) N/A 9 York U. 1 1 (100%) N/A 20 École polytechnique de Montréal 7 3 (43%) N/A 14 McGill U. 33 8 (24%) 89/1.1 4 U. Laval 23 1 (4%) N/A 6 U. Montréal 32 10 (31%) N/A 5 U. Québec à Montréal 3 1 (33%) N/A 17 U. Sherbrooke 4 1 (25%) N/A 16 5 0 N/A 15 alBerta BC ManitoBa neW BrunsWiCK New Brunswick Heart Centre neWfoundland & laBrador nova sCotia ontario QuÉBeC sasKatCHeWan U. Saskatchewan 43 CANADIAN ASSET MAP FOR STEM CELL AND REGENERATIVE MEDICINE table 10. Institutions Housing More Than Ten Researchers in Stem Cell and Regenerative Medicine Research universitY affiliation Head # res./CHairs* Ontario Cancer Institute (OCI), UHN [UHN also includes Toronto General Research Institute and Toronto Western Research Institute] U. Toronto, ON Director OCI: Neel, Benjamin 19/1 Hospital for Sick Children (Sick Kids) U. Toronto, ON Chief of Research: Rossant, Janet 16/4 Sprott Centre for Stem Cell Research, Ottawa Hospital Research Institute (OHRI) U. Ottawa, ON Director Sprott: Rudnicki, Michael; CEO & Sci. Director OHRI: Stewart, Duncan 14/5 McEwen Centre for Regenerative Medicine, Toronto General Research Institute, University Health Network (UHN) U. Toronto, ON Director McEwan: Keller, Gordon 12/6 Sunnybrook Research Institute (SRI), Sunnybrook Health Sciences Centre (SHSC) U. Toronto, ON Terry Fox Research Labs. UBC thru BCCA, BC Director: Humphries, Keith 10/1 LOEX (Experimental Organogenesis Laboratory— Laboratoire d’organogénèse expérimentale) U. Laval, QC Director: Auger, François A Sci. Director: Germain, Lucie 10/1 researCH institution *First number is the number of researchers/second number is number of endowed Chairs. 44 12/1 VP Research SRI: Julius, Michael KEY RESEARCHERS AND INSTITUTIONS desCription url Researchers employ state-of-the-art tools in genomics, proteomics, structural biology, molecular biology, biophysics and the behavioural sciences. With these tools they analyze cancerous cells at the molecular level; test gene and cellular therapies for cancer and other diseases; develop new technologies for diagnosing and treating cancer; determine the effects of diet and behaviour on cancer risks; and develop and test informatics tools for the large-scale analysis of patient populations. www.uhnresearch.ca/ institutes/oci One of the world’s foremost paediatric health-care institutions and Canada’s leading centre dedicated to advancing children’s health through the integration of patient care, research and education. SickKids is one of Canada’s most research-intensive hospitals and has generated discoveries that have helped children globally. www.sickkids.ca One of the leading regenerative medicine centres in Canada. Houses the OHRI’s Regenerative Medicine Program (which encompasses basic sciences such as stem cell biology, molecular genetics and molecular biology, and applied sciences such as transplantation and tissue engineering); headquarters for Canada’s Stem Cell Network. Provides an important hub for stem cell research community in Ottawa. www.ohri.ca/centres/ StemCellResearch/default.asp Aims to be a world-renowned centre for stem cell biology and regenerative medicine. Working to accelerate the development of more effective treatments for conditions such as heart disease, diabetes, respiratory disease and spinal cord injury. Distributes their stem cells globally. www.mcewencentre.com Main aims are to understand and prevent disease, and develop treatments that enhance and extend life. Main areas of expertise are in clinical epidemiology and health sciences; clinical integrative biology; imaging; and molecular and cellular biology. sunnybrook.ca/research Aims to fuel major improvements in cancer outcomes through basic and translational research with a current focus on cancer stem cells. Faculty comprise experts with diverse backgrounds in biology and medicine and internationally recognized leadership in normal and leukemic stem cell investigations, innate and acquired immunity, embryo and tissue development, telomere biology and aging, signalling, genomics, live cell banking, cell separation, imaging and molecular analysis, and bioinformatics and data management. Strategies range from the investigation of model organisms to experiments with patient’s cells and the initiation and laboratory support of clinical trials. www.terryfoxlab.ca An international leader in tissue engineering. Its strength lies principally in epidermal culture and its selfassembly approach to tissue engineering. Activities cover four major areas: Stem cells, differentiation and cellular interactions; Cutaneous, cardiovascular, orthopedic, ophthalmologic, pulmonary and urinary tissue reconstruction; Biological applications of reconstructed tissues (physiology, pathophysiology, pharmacology, toxicology, transplantation) and pre-clinical trials; Clinical applications of cellular and tissue-based therapies. www.cha.quebec.qc.ca/en/ www/research/index.html 8 www.loex.qc.ca table 11. Research Institutes Housing between Five and Ten Researchers researCH institute universitY affiliation # res./ CHairs * url Samuel Lunenfeld Research Institute, Mount Sinai Hospital U. Toronto, ON 8/3 www.lunenfeld.ca The Donnelly Centre U. Toronto, ON 8/2 thedonnellycentre.utoronto.ca Stem Cell and Cancer Research Institute McMaster U., ON 7/4 sccri.mcmaster.ca Institut de recherches cliniques de Montréal U. Montréal, QC 7/3 ircm.qc.ca Hotchkiss Brain Institute U. Calgary, AB 7/1 www.hbi.ucalgary.ca Vancouver Coastal Health Research Institute UBC, BC 7/0 www.vchri.ca BC Cancer Agency (excl. Terry Fox Laboratory) UBC, BC 6/1 www.bccrc.ca Biomedical Research Centre UBC, BC 6/1 www.brc.ubc.ca Ottawa Hospital Research Institute U. Ottawa, ON 5/1 www.ohri.ca The Research Institute of the McGill University Health Centre McGill U., QC 5/0 muhc.ca *First number is the number of researchers/second number is number of Endowed Chairs. 45 CANADIAN ASSET MAP FOR STEM CELL AND REGENERATIVE MEDICINE ConClusion In keeping with the fact that Canadian researchers were the first to identify many types of stem cells, Canada has a significant number of current researchers in this field (416 in professor or associate professor positions), many of them internationally renowned. Canada remains among the world leaders in stem cell research, with Ontario, and the University of Toronto in particular, having the greatest number of researchers and highest levels of funding. Researchers’ main area of focus is tissuespecific stem cells (not embryonic stem cells as may have been assumed), particularly hematopoietic, and the most common disease area targeted is cancer. However, a number of other disease areas are also important, particularly neurological, musculoskeletal, and cardiovascular conditions. aCKnoWledgeMents We would like to thank everyone who participated in the creation of this document including Eric Cloutier, Policy Advisor, Life Science Industries Branch, Industry Sector, Industry Canada; Sue Kingsley, President, International BioPharma Solutions Ltd. (IBPS); Richard Taylor, via IBPS; Helen Kingsley, via IBPS; Drew Lyall, Executive Director, Canadian Stem Cell Network and Board of Directors of the Canadian Stem Cell Foundation and Canadian Stem Cell Consortium; Michael Rudnicki, Scientific Director, Canadian Stem Cell Network and Senior Scientist and Director of the Regenerative Medicine Program and the Sprott Centre for Stem 46 Cell Research, Ottawa Hospital Research Institute; Cindy Bell, Interim Executive Director, Cancer Stem Cell Consortium and Executive VP Corporate Development, Genome Canada; Gordon Keller, Canada Research Chair in Embryonic Stem Cell Biology, Director, McEwen Centre for Regenerative Medicine, University Health Network, University of Toronto; Juan Carlos Zúñiga-Pflücker, Director of the Advanced Regenerative Tissue Engineering Centre, University of Toronto; Jim Till, President, Cancer Stem Cell Consortium and Board of Directors of the Canadian Stem Cell Foundation. ContaCts Industry Canada, Life Science Industries Branch Eric Cloutier 613-941-6479 [email protected] www.ic.gc.ca/lsib International BioPharma Solutions Ltd. Sue Kingsley 604-408-4310 [email protected] www.BioPharmaSolutions.com 47 appendiX 1 Methodology tHis asset Map Was Created as folloWs: 1. Initial information on regenerative medicine research in Canada was obtained from: • Provincial regenerative medicine asset maps: – Ontario’s MaRS Regenerative Medicine 2009 Industry Briefing report (www.marsdd.com/buzz/reports/ regenerativemedicine) – Ontario’s MaRS Regenerative Medicine Asset Map 2009 (www.trra.ca/en/ sectors/resources/MRI_asset_maps_ RM_050809.pdf) – The BC Regenerative Medicine Asset Map (www.tted.gov.bc.ca/MIT/SBIIO/ Documents/AssetMap_RegenMed.pdf) • The websites of: – Canada Research Chairs (www.chairs-chaires.gc.ca) – Canadian Stem Cell Network (www.stemcellnetwork.ca) – Canadian Stem Cell Consortium (www.cancerstemcellconsortium.com) – Canadian Stem Cell Foundation (stemcellfoundation.ca/#/aboutUs) • Industry Canada’s Life Science Industries Branch. 48 2. Using this information, we identified key leaders within the area of Canadian regenerative medicine research. We contacted 10 of these individuals by email to ask for an interview or for information. Six replied and, using a discussion guide we created for this purpose, we interviewed five (listed in Appendix 2) to gain factual information and inform the structure and contents of the final report. 3. The results of the interviews informed some of the other secondary research sources we used to obtain information on regenerative medicine researchers and research centres in Canada. Information was obtained from the websites and reports listed in activity (1), as well as the following websites, using key word searches “stem cells”, “tissue engineering”, and “regenerative”. Data on researchers and their projects (as well as their associated funding, where available) were obtained for the past 5 years (2006/7 to 2010/11) and, in some cases, into the future from: • Canada Foundation for Innovation (www.innovation.ca/projects/index.cfm) • Canadian Institutes of Health Research (www.cihr-irsc.gc.ca/e/826.html) • Genome Canada (www.genomecanada. ca/en/portfolio/project/health. aspx; www.genomecanada.ca/en/ portfolio/project/technologies. appendiX METHODOLOGY • • • • • • • • • • • • • • • aspx; genomereports.ca/section. php?Lang=En&ID=3&Nav=Section) Networks of Centres of Excellence (www.nce-rce.gc.ca/NetworksCentresCentresReseaux/NCE-RCE_eng.asp) National Research Council Canada (www.nrc-cnrc.gc.ca) Natural Sciences and Engineering Research Council of Canada (www.outil.ost.uqam.ca/crsng/Outil. aspx?Langue=Anglais) US National Institutes of Health (projectreporter.nih.gov/reporter.cfm) Terry Fox Foundation (www.tfri.ca/ programs/foundation_programs.asp) Wellcome Trust (www.wellcome.ac.uk/ Funding/International/index.htm —no Canadian projects found) MSFHR (Michael Smith Foundation for Health Research: www.msfhr.org) Alberta Heritage Foundation for Medical Research—Alberta Innovates (www.ahfmr.ab.ca/experts/search.php) Saskatchewan Health Research Foundation (www.shrf.ca) Manitoba Health Research Council (researcherdirectory.mb.ca/eprojects/ prod/mhrc/mhrcdirectory/index.html) Ontario Ministry of Research and Innovation (www.mri.gov.on.ca/english/ default.asp) Fonds de la Recherche en Santé du Québec (www.frsq.gouv.qc.ca/en/ recherche_sante/expertise_quebecoise. shtml) Nova Scotia Health Research Foundation (www.nshrf.ca/AbsPage. aspx?siteid=1&lang=1&id=1) New Brunswick Health Research Foundation (www.nbhrf.com) Newfoundland and Labrador Centre for Applied Health Research (www.nlcahr. mun.ca/research/). 1 4. Information obtained on researchers from all the aforementioned websites and asset maps was entered into a master Excel spreadsheet. Over 2,000 lines of data were checked for relevance to this project: studentship (undergraduate, Master’s, Doctoral) and postdoctoral fellowship projects and duplicates were deleted; and researchers’ location and activities were checked against their websites to ensure they worked in the research areas covered by this Asset Map and were still residents of Canada. Researchers’ specialties were determined from their funded projects and websites. International reputation was also considered in terms of endowed research chairs and key accomplishments, with data for these being obtained from both CRC and researcher websites, as well as Industry Canada. 5. In terms of funding, dollar amounts were generally only available from federal databases: CFI, CIHR, NSERC, Genome Canada, and NIH. Funding amounts were also available from the Terry Fox Foundation and for some projects supported by the Ontario Ministry of Research and Innovation and Saskatchewan Health Research Foundation. The amount of NCE funding was generally gleaned from press releases. CRC funding was calculated according to the number of years a researcher had been a CRC at $100,000/yr for 5 years for a Tier 2 researcher and $200,000/yr for Tier 1 researcher. Such calculations were only conducted if the CRC funding was not included in the NSERC or CIHR information obtained. Where large-scale grants had been announced before January 2011 but monies would be released in the future, only funds deemed to have been used up to 2010/11 were included in the analyses. However, it was not always possible to determine when 49 1 appendiX METHODOLOGY the money was made available and in those cases, funds were assumed to be released within a few months of the announcement. Although the SCN breaks down its funds for individual research projects, generally only total NCE funding for the Network was used in the analysis as the individual data were not identified until the end of this project. The NCE funds were dedicated to the University of Ottawa where the SCN is located. NCE funds comprised less than 10% of total funding so although a breakdown according to SCN grants across Canada would have made some difference to provincial and university funding (Figures 2 and 3), it would probably have not been significant except as concerns the University of Ottawa. Even so, this university would still have ranked among the top five. On the other hand, funding for key researchers (Section 8.1) did include those granted by the SCN. 6. The data for each relevant researcher were categorized according to institution, province, and key research areas. When key research institutes had been identified from this categorization, the websites of those institutes were checked to locate other researchers that may have been missed. 7. Analyses were conducted in Excel to determine researcher numbers, expertise, and government funding according to province and institution; and key researchers according to the amount of funding obtained. 8. For general information on stem cells/ regenerative medicine and Canada’s position in stem research we used the sources listed in Appendix 5, some of which were provided 50 by interviewees and Industry Canada Life Science Industries Branch. 9. Information on biobank support facilities was obtained from the existing asset maps and Google searches using key words of province or Canada and “cord blood bank”, “tissue bank”, “biobank”, or “biorepository”; some information on biobanks was obtained from www.specimencentral.com/ biobank-directory.aspx. Information on other relevant support facilities came from existing asset maps and the research on researchers and their facilities. 10. Information on networks was obtained from Activity (2) interviews, the websites for the FRSQ (www.frsq.gouv.qc.ca/en/ index.shtml), NCE (www.nce-rce.gc.ca/ NetworksCentres-CentresReseaux/NCERCE_eng.asp), and Google searches using key words of province or Canada plus “research network” or “research group”. 11. Information on key research centres was obtained form those centres’ websites. 12. Information on Canada’s global position and expertise was obtained through factual data gathered during Activity 2 interviews, information contained in the MaRS Regenerative Medicine 2009 Industry Briefing report, and other publications as shown in Appendix 5. appendiX INTERVIEWEES 2 2 Interviewees 1. Bell, Cindy. Interim Executive Director, Cancer Stem Cell Consortium and Executive VP Corporate Development, Genome Canada. [email protected]; T: 613-751-4460. Interviewed December 21, 2010. 5. Zúñiga-Pflücker, Juan Carlos. Director of the Advanced Regenerative Tissue Engineering Centre, University of Toronto. (www.sunnybrook.ca/research/team/ member.asp?t=13&m=191&page=1100) [email protected]; T: 416-480-6112. Interviewed Dec 16, 2010. 2. Keller, Gordon. Canada Research Chair in Embryonic Stem Cell Biology, Director, McEwen Centre for Regenerative Medicine, University Health Network, University of Toronto. (www.uhnres.utoronto.ca/ researchers/profile.php?lookup=12091. medbio.utoronto.ca/faculty/keller.html. www.trra.ca/en/profiles/gkeller.asp). [email protected]; T: 416-581-7694. Interviewed Dec 23, 2010. 3. Lyall, Drew (Andrew). Executive Director, Canadian Stem Cell Network and Board of Directors of the Canadian Stem Cell Foundation and Canadian Stem Cell Consortium. (www.stemcellnetwork.ca/ index.php?page=network-staff&hl=eng). [email protected]; T: 613-739-6675. Interviewed Dec 17, 2010. 4. Rudnicki, Michael. Scientific Director, Canadian Stem Cell Network Senior Scientist and Director of the Regenerative Medicine Program and the Sprott Centre for Stem Cell Research, Ottawa Hospital Research Institute. (www.ohri.ca/profiles/rudnicki.asp). [email protected]; T: 613-739-6740. Interviewed Dec 20, 2010. 51 3 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE RESEARCHERS 3a. Researchers in Alphabetical Order researCHer researCH institution Acker, Jason provinCe tYpe of regen. Med U. Alberta AB Tissue engineering— cell storage Akimenko, Marie-Andrée Ottawa Hospital Research Institute U. Ottawa ON Regeneration—tissue Allan, Alison London Regional Cancer Program, London Health Sciences Centre U. Western Ontario ON Stem cells—cancer Allan, David Sprott Centre for Stem Cell Research, Ottawa Health Research Institute U. Ottawa ON Stem cells— hematopoietic Alman, Benjamin Hospital for Sick Children U. Toronto ON Stem cells— mesenchymal Amsden, Brian Queens U. ON Tissue engineering— scaffolds Anderson, Colin C. U. Alberta AB Stem cells— pancreatic (islet) U. Toronto ON Stem cells— hematopoietic Annabi, Borhane U. Québec à Montréal QC Stem cells— unspecified Antel, Jack McGill U. QC Stem cells—adult Anderson, Michele Sunnybrook Research Institute Antoniou, John Jewish General Hospital McGill U. QC Tissue engineering— scaffold; Stem cells— mesenchymal Aparicio, Samuel BC Cancer Agency U. British Columbia BC Stem cells—various— hematopoietic, induced pluripotent Arora, Rakesh C. Associated with National Research Council of Canada, Institute for Biological Sciences U. Manitoba MB Stem cells—fat Atkins, Harry Sprott Centre for Stem Cell Research, Ottawa Health Research Institute U. Ottawa ON Stem cells— hematopoietic U. Toronto ON Stem cells— mesenchymal Aubin, Jane 52 universitY/ institution Audet, Julie Institute of Biomaterials and Biomedical Engineering U. Toronto ON Stem cells— hematopoietic Auger, François A. LOEX U. Laval QC Tissue engineering— cell culture Bader, Gary Institute of Biomaterials and Biomedical Engineering U. Toronto ON Stem cells—embryonic appendiX 3A. RESEARCHERS IN ALPHABETICAL ORDER disease endoWed CHair Various url eMail No lmp.med.ualberta.ca/Admin/Faculty/Pages/default. aspx?P=13 [email protected] Musculoskeletal No www.careg.uottawa.ca/bio_marie_andree_ akimenko.htm [email protected] Cancer—breast No www.uwo.ca/anatomy/department/allana/aallan.html [email protected] Cardiovascular No www.ohri.ca/profiles/allan.asp [email protected] Musculoskeletal CRC in Musculoskeletal Research; A.J. Latner Professor and Chair of Orthopaedic Surgery www.sickkids.ca/AboutSickKids/Directory/People/A/ Benjamin-Alman-Staff-Profile.html [email protected] Various No chemeng.queensu.ca/people/faculty/amsden/ [email protected] Metabolic—diabetes No www.ualberta.ca/~smri/Surgery Research Web Page/DrAnderson.htm [email protected] Cancer—leukemia, lymphoma No www.immunology.utoronto.ca/faculty/directory/ anderson.htm [email protected] Cancer CRC in Molecular Oncology borhaneannabi.net/index.php?option=com_content& view=section&layout=blog&id=2&Itemid=2 [email protected] Neurological—multiple sclerosis No www.mni.mcgill.ca/neuro_team/cru/jack_antel/ [email protected] Musculoskeletal No orthodoc.aaos.org/antoniou/ [email protected] Cancer—breast CRC in Molecular Oncology; Nan and Lorraine Robertson Chair www.pathology.ubc.ca/NewPathology/Professor/ Samuel_Aparicio.html [email protected] Cardiology No www.sbrc.ca/content/blogcategory/59/93/ [email protected] Various, incl. cancer— hematopoietic, neurological—MS No www.ohri.ca/profiles/atkins.asp [email protected] Musculoskeletal No medbio.utoronto.ca/faculty/aubin.html [email protected] Various No individual.utoronto.ca/julie_audet/ [email protected] Various, incl. cardiovascular, transplantation, injury No www.loex.qc.ca/chercheurs.cv.php?id=2 [email protected] Various No www.lunenfeld.ca/researchers/bader [email protected] 3 53 3 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE RESEARCHERS 3a. Cont’d universitY/ institution provinCe tYpe of regen. Med U. Ottawa ON Stem cells—adult U. Laval QC Stem cells— hematopoietic U. Toronto ON Stem cells— hematopoietic Barralet, Jake McGill U. QC Biomaterials Barrett, Christopher McGill U. QC Biomaterials Baylis, Françoise Dalhousie U. NS Social science & humanities researCHer researCH institution Bani, Mahmud Associated with National Research Council of Canada, Institute for Biological Sciences Barabé, Frédéric Barber, Dwayne Ontario Cancer Institute, University Health Network Beausejour, Christian Hôpital Sainte-Justine (Montréal) U. Montréal QC Stem cells— hematopoietic Behie, Leo Includes: Pharmaceutical Production Research Facility U. Calgary AB Bioprocessing—stem cells production/ culture Ben-David, Yaacov Sunnybrook Research Institute U. Toronto ON Stem cells— hematopoietic U. Ottawa ON Stem cells—neural U. Laval QC Tissue engineering— stem cells U. Western Ontario ON Stem cells— pluripotent— induced pluripotent Bennett, Steffany Berthod, François LOEX Betts, Dean Bhatia, Mickie Stem Cell and Cancer Research Institute McMaster U. ON Stem cells—various— pluripotent, embryonic, hematopoietic Biernaskie, Jeffrey A. Associated with Hotchkiss Brain Institute U. Calgary AB Stem cells—dermal Bijl, Janetta U. Montréal QC Stem cells— hematopoietic Bjerknes, Matthew J. U. Toronto ON Stem cells— gastrointestinal Bramson, Jonathan McMaster U. ON Stem cells—cancer U. Ottawa ON Stem cells— hematopoietic McMaster U. ON Biomaterials Brand, Marjorie Brash, John 54 Sprott Centre for Stem Cell Research, Ottawa Health Research Institute appendiX 3A. RESEARCHERS IN ALPHABETICAL ORDER disease endoWed CHair url eMail Neurological—brain injury No www.med.uottawa.ca/NSC/eng/dr_mahmud_bani. html [email protected] Cancer—leukemia No www.cri.ulaval.ca/?fbarabe_eng [email protected] Hematological— anemia, cancer No www.uhnres.utoronto.ca/researchers/profile. php?lookup=335 [email protected] Musculoskeletal— bone formation CRC in in Osteoinductive Biomaterials www.mcgill.ca/dentistry/research/barralet/ [email protected] Various No www.chemistry.mcgill.ca/directory/people. php?p=9&n=Barrett&t=materials [email protected] SSH: Ethics CRC in Bioethics & Philosophy bioethics.medicine.dal.ca/people/fbaylis.php [email protected] Cancer No www.chu-sainte-justine.org/research/chercheurs. aspx?id_nouveau=65947859&id_page=2432&id_ menu=2429 [email protected] Various—neurological, metabolic-diabetes CRC in Biomedical and Biochemical Engineering schulich.ucalgary.ca/resrch_chem/Chem_Behie.htm [email protected] Cancer—leukemia No medbio.utoronto.ca/faculty/bendavid.html [email protected] Neurological, incl. Alzheimer’s No www.med.uottawa.ca/bmi/eng/bennett.html [email protected] Various, incl. neurological, urological, cutaneous No www.cha.quebec.qc.ca/en/www/research/theresearch-centre/researchers/francois-berthod/index. html [email protected] Various No www.uwo.ca/physpharm/facultyprofile/betts.html [email protected] Various, incl. respiratory—lung disease CRC in Human Stem Cell Biology; Krembil Chair in Stem Cell Biology sccri.mcmaster.ca/bhatia_mick.html [email protected] Neurological—injury, wound healing No www.ucalgary.ca/research4kids/members/ biernaskie_full [email protected] Cancer—leukemia No recherche.maisonneuve-rosemont.org/en-ca/ research/our-research-investigators/bijl-janet.html [email protected] Gastrointestinal No medbio.utoronto.ca/faculty/bjerknes.html [email protected] Cancer No fhs.mcmaster.ca/cgt/bramson_jonathan.html [email protected] Hematological—ßthalassemia and sickle cell anemia CRC in the Regulation of Gene Expression www.ohri.ca/profiles/brand.asp [email protected] Various No chemeng.mcmaster.ca/brash.html [email protected] 3 55 3 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE RESEARCHERS 3a. Cont’d researCHer researCH institution universitY/ institution provinCe tYpe of regen. Med Brinkman, Ryan Terry Fox Laboratory, BC Cancer Agency U. British Columbia BC Stem cells—cancer Brodt, Pnina The Research Institute of the McGill University Health Centre McGill U. QC Stem cells—adult— stromal Brunette, Donald Biomedical Research Centre U. British Columbia BC Tissue engineering— biomaterials, stem cells—mesenchymal U. Alberta AB Social science & humanities U. British Columbia BC Tissue engineering— biomaterials, stem cells—mesenchymal École polytechnique de Montréal QC Biomaterials U. Montréal QC Stem cells—neural U. Ottawa ON Biomaterials; Tissue engineering—stem cells Bubela, Tania Burt, Helen Mary Biomedical Research Centre Buschmann, Michael Calderone, Angelo Montreal Heart Institute Cao, Xudong Carreau, Madeleine Centre hospitalier de l’Université Laval U. Laval QC Stem cells— hematopoietic Carrier, Patrick LOEX U. Laval QC Stem cells—epithelial (from cornea) Casper, Robert Samuel Lunenfeld Research Institute, Mount Sinai Hospital U. Toronto ON Stem cells— hematopoietic Catelas, Isabelle U. Ottawa ON Tissue engineering Caulfield, Tim U. Alberta AB Social science & humanities U. Montréal QC Stem cells—neural U. Ottawa ON Social science & humanities McGill U. QC Tissue engineering— artificial blood cells Chen, Daniel (Xiongbiao) U. Saskatchewan Sask Tissue engineering— scaffolds Chen, Jie U. Alberta AB Stem cells—cord blood U. Toronto ON Stem cells— unspecified U. Victoria BC Stem cells—retinal Cayouette, Michel Institut de recherches cliniques de Montréal Chandler, Jennifer Chang, Thomas Ming Swi Cheng, Hai-Ling Margaret Chow, Bob 56 Artificial Cells and Organs Research Centre Sunnybrook Research Institute appendiX 3A. RESEARCHERS IN ALPHABETICAL ORDER disease endoWed CHair url eMail Cancer No www.terryfoxlab.ca/people/RBrinkman/ryan.aspx [email protected] Cancer No www.mcgill.ca/translational-research-cancer/ researcher-biographies/brodt/ [email protected] Musculoskeletal No www.dentistry.ubc.ca/research/brunette.html [email protected] SSH: Socioeconomic benefits No www.publichealth.ualberta.ca/en/research/ researchers_supersivors/faculty/bubela.aspx [email protected] Musculoskeletal No https://www.directory.ubc.ca/index.cfm?page=perso nDetail&row=104080471 [email protected] Musculoskeletal— cartilage cell delivery CRC in Cartilage Tissue Engineering www.groupes.polymtl.ca/tissue/en/staff/buschmann. php [email protected] Cardiology No www.recherche.umontreal.ca/chercheurs_unites/ chercheur_affichage.asp?noseq_chercheur=1596 [email protected] Neurological—spinal cord, eye No www.engineering.uottawa.ca/en/directory/view/ xudong_cao/ [email protected] Hematological— anemia No www.crchuq.ulaval.ca/en/research/researchers/8076 [email protected] Eye No www.cha.quebec.qc.ca/en/www/research/theresearch-centre/researchers/patrick-carrier/index. html [email protected] Reproduction—female fertility No www.obgyn.utoronto.ca/faculty/list/All-Faculty/ Casper.htm [email protected] Musculoskeletal— bone loss CRC in Bioengineering in Orthopedics www.engineering.uottawa.ca/en/directory/view/ catelas_isabelle/ [email protected] SSH: Ethics and law CRC in Health Law and Policy www.law.ualberta.ca/facultystaff/profiles/caulfield. php [email protected] Neurological, including eye No www.cenum.umontreal.ca/membres/2_titulaires/ en_cayouette_m.html [email protected] SSH: Law, policy No www.commonlaw.uottawa.ca/en/jennifer-chandler. html [email protected] Various, incl. cardiovascular No www.medicine.mcgill.ca/artcell/ [email protected] Neurological— peripheral No www.engr.usask.ca/faculty/Chen_Daniel.php [email protected] Various No www.ece.engineering.ualberta.ca/en/FacultyStaff/ FacultyAcademic/JieChen.aspx [email protected] Neurological—stroke No www.sickkids.ca/AboutSickKids/Directory/People/C/ Hai-Ling-Margaret-Cheng-Staff-Profile.html [email protected] Eye CRC in Retinal and Early Eye Development web.uvic.ca/biology/faculty/facpages/chow.html [email protected] 3 www.labome.org/expert/canada/mcgill/chang/ thomas-ming-swi-chang-253343.html 57 3 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE RESEARCHERS 3a. Cont’d researCHer researCH institution Couban, Stephen provinCe tYpe of regen. Med Dalhousie U. NS Stem cells—cord blood Courtman, David Sprott Centre for Stem Cell Research, Ottawa Hospital Research Institute U. Ottawa ON Stem cells—adult— endothelial progenitor Cregan, Sean John P. Robarts Research Institute U. Western Ontario ON Stem cells—neural U. Calgary AB Stem cells— various—embryonic, trophoblast, placental, germline Cross, James Charles Crump, Michael A. Ontario Cancer Institute, University Health Network U. Toronto ON Stem cells— hematopoietic Daar, Abdallah McLaughlin-Rotman Centre for Global Health, University Health Network U. Toronto ON Social science & humanities Dankort, David McGill U. QC Stem cells—cancer Davies, John U. Toronto ON Tissue engineering— scaffolds; Stem cells— mesenchymal De Crescenzo, Gregory École polytechnique de Montréal QC Biomaterials DeCoteau, John U. Saskatchewan Sask Stem cells—cancer Dedhar, Shoukat BC Cancer Agency U. British Columbia BC Stem cells—mammary Dekaban, Gregory John P. Robarts Research Institute U. Western Ontario ON Stem cells— unspecified McMaster U. ON Stem cells— hematopoietic Denburg, Judah Aryeh Dennis, James W. Samuel Lunenfeld Research Institute, Mount Sinai Hospital U. Toronto ON Stem cells— unspecified Dick, Alexander Sunnybrook Research Institute U. Toronto ON Stem cells— mesenchymal Dick, John McEwen Centre for Regenerative Medicine and Ontario Cancer Institute, University Health Network U. Toronto ON Stem cells—various, incl. hematopoietic Dilworth, Jeffrey Sprott Centre for Stem Cell Research, Ottawa Health Research Institute U. Ottawa ON Stem cells—muscle progenitors Dirks, Peter Hospital for Sick Children U. Toronto ON Stem cells—neural Doble, Bradley Stem Cell and Cancer Research Institute McMaster U. ON Stem cells—embryonic U. Calgary AB Stem cells— germline—testis Dobrinski, Ina 58 universitY/ institution appendiX 3A. RESEARCHERS IN ALPHABETICAL ORDER disease endoWed CHair url eMail Cancer— hematological No dom.medicine.dal.ca/clinicaldivisions/hematology/ faculty.htm [email protected] Cardiopulmonary No www.ohri.ca/profiles/courtman.asp [email protected] Neurological CRC in Neurodegeneration and Stem Cell Regeneration www.uwo.ca/physpharm/faculty/cregan_sean.html [email protected] Reproduction—female No people.ucalgary.ca/~jcross/homepage.html [email protected] Cancer—lymphoma No www.uhnresearch.ca/researchers/profile. php?lookup=1254 [email protected] SSH: Ethics and law No www.uhnresearch.ca/researchers/profile. php?lookup=18592 [email protected] Cancer No biology.mcgill.ca/faculty/dankort/index.html [email protected] Musculoskeletal— bone No www.utoronto.ca/dentistry/facultyresearch/ facultyprofiles/john_davies.html [email protected] Various— musculoskeletal, cardiovascular CRC in ProteinEnhanced Biomaterials www.polymtl.ca/recherche/rc/en/professeurs/ details.php?NoProf=302 [email protected] Cancer No www.medicine.usask.ca/pathology/people/faculty/ dr-j-decoteau/ [email protected] Cancer No www.bccrc.ca/dept/ic/genetics/shoukat-dedhar-phd [email protected] Neurological—spinal cord injury No www.robarts.ca/biotherapeutics/Dekaban.htm [email protected] Immunological— allergy, asthma No fhs.mcmaster.ca/medicine/Immunology_Allergy/ faculty_member_denburg.htm [email protected] Cancer, other CRC in Glycobiology www.lunenfeld.ca/researchers/dennis [email protected] Cardiology No sunnybrook.ca/research/team/member. asp?t=10&m=53&page=172 [email protected] Cancer, incl. leukemia CRC in Stem Cell Biology www.uhnres.utoronto.ca/researchers/profile. php?lookup=1468 [email protected] Musculoskeletal: Duchenne CRC in Epigenetic Regulation of Transcription www.ohri.ca/profiles/dilworth.asp [email protected] Cancer—brain No www.sickkids.ca/AboutSickKids/Directory/People/D/ Peter-Dirks.html [email protected] Cancer CRC in Stem Cell Signaling www.fhs.mcmaster.ca/SCCRI/faculty/doble.html [email protected] Reproduction—male No www.ucalgary.ca/bmb/dobrinski [email protected] 3 59 3 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE RESEARCHERS 3a. Cont’d universitY/ institution provinCe Doillon, Charles U. Laval QC Tissue engineering— biomaterials Downey, Gregory U. Toronto ON Regenerative medicine—unspecified Doyle, John U. Toronto ON Stem cells— hematopoietic researCHer researCH institution Draper, Jonathan Stem Cell and Cancer Research Institute McMaster U. ON Stem cells—embryonic Drouin, Jacques Institut de recherches cliniques de Montréal U. Montréal QC Stem cells—fetal Duff, Henry Joseph U. Calgary AB Stem cells— unspecified Dufort, Daniel McGill U. QC Stem cells—embryonic U. Toronto ON Stem cells—embryonic U. Montréal QC Stem cells—cord blood Dumont, Dan Sunnybrook Research Institute Duval, Michel Dyck, Richard Henry Associated with Hotchkiss Brain Institute U. Calgary AB Stem cells— unspecified Eaves, Allen Terry Fox Laboratory, BC Cancer Agency U. British Columbia BC Stem cells— hematopoietic Eaves, Connie Terry Fox Laboratory, BC Cancer Agency U. British Columbia BC Stem cells—various (embryonic, hematopoietic, breast epithelial) Egan, Sean Hospital for Sick Children U. Toronto ON Stem cells—mammary epithelial Einsiedel, Edna U. Calgary AB Social science & humanities El-Hakim, Assaad McGill U. QC Tissue engineering— biomaterials, cells McGill U. QC Stem cells— mesenchymal Elliott, Janet Anne Wade U. Alberta AB Technology— stem cells— cryopreservation Ellis, Anne Queen’s U. ON Stem cells— hematopoietic (cord blood) U. Toronto ON Stem cells— pluripotent— embryonic, induced pluripotent Eliopoulos, Nicoletta Ellis, James 60 tYpe of regen. Med Jewish General Hospital, Lady Davis Institute for Medical Research Hospital for Sick Children appendiX 3A. RESEARCHERS IN ALPHABETICAL ORDER endoWed CHair url eMail Various— cardiovascular, cancer No www.crchuq.ulaval.ca/en/research/researchers/4683 [email protected] Respiratory CRC in Respiration Sciences www.utoronto.ca/respirology/who/Gregory_Downey. html [email protected] Cancer No www.paeds.utoronto.ca/faculty/doyle.htm [email protected] Various CRC in Human Stem Cell Lineage Commitment sccri.mcmaster.ca/draper_jon.html [email protected] Neurological— Parkinson’s GlaxoSmithKline Chair in Molecular Genetics www.ircm.qc.ca/en/recherche/statique/unite27.html [email protected] Cardiology No cardiacsciences.ucalgary.ca/research/#duff [email protected] Reproduction— implantation No www.medicine.mcgill.ca/expmed/staff/dufort_daniel. htm [email protected] Various— cardiovascular, cancer No medbio.utoronto.ca/faculty/dumont.html [email protected] Various No www.chu-sainte-justine.org/research/chercheurs. aspx?ID_nouveau=38393948&id_page=2432&id_ menu=2429 [email protected] Neurological—brain No www.cell.ucalgary.ca/r_dyck.html [email protected] Cancer—leukemia No www.bccrc.ca/dept/terry-fox-laboratory/faculty/dr.allen-eaves [email protected] Cancer No www.bccrc.ca/dept/terry-fox-laboratory/faculty/dr.connie-eaves [email protected] Cancer—breast No www.sickkids.ca/AboutSickKids/Directory/People/E/ Sean-Egan.html [email protected] SSH: Social science No www.ucalgary.ca/einsiedel/ [email protected] Urological No urology.mcgill.ca/clinicalStaff/associatePart/ElHakim_A.html [email protected] Renal No www.ladydavis.ca/en/nicolettaeliopoulos [email protected] Various CRC in Interfacial Thermodynamics www.cme.engineering.ualberta.ca/en/FacultyStaff/ FacultyAcademicStaff/Elliott.aspx [email protected] Immunological— allergy No microimm.queensu.ca/facultyPages/cross_ appointed/ellis.html [email protected] Various, incl. neurological, incl. Rett’s; hematological— anemia No www.sickkids.ca/Research/Ellis-Lab/index.html [email protected] disease 3 61 3 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE RESEARCHERS 3a. Cont’d researCHer researCH institution Emery, Gregory provinCe tYpe of regen. Med U. Montréal QC Stem cells— unspecified Emili, Andrew The Donnelly Centre—Banting and Best Department of Medical Research U. Toronto ON Stem cells—embryonic Farhat, Walid Hospital for Sick Children U. Toronto ON Tissue engineering — cells, scaffold Farookhi, Riaz McGill U. QC Stem cells—ovarian epithelial Faucheux, Nathalie U. Sherbrooke QC Biomaterials— scaffolds Favis, Basil École polytechnique de Montréal QC Biomaterials— scaffolds Fehlings, Michael McEwen Centre for Regenerative Medicine and McLaughlin Centre for Molecular Medicine, Toronto Western Research Institute, University Health Network U. Toronto ON Stem cells—neural Ferguson, Peter Charles Mount Sinai Hospital U. Toronto ON Stem cells— mesenchymal stromal Fernandes, Karl U. Montréal QC Stem cells—neural Fernlund, Goran U. British Columbia BC Tissue engineering— biomaterials, stem cells—mesenchymal Figeys, Daniel U. Ottawa ON Stem cells—cell handling Filiaggi, Mark J. Dalhousie U. NS Biomaterials Flynn, Lauren Queen’s U. ON Stem cells—fat; Tissue engineering— scaffolds U. Laval QC Stem cells—fat; Tissue engineering Frei, Hanspeter Carleton U. ON Stem cells— mesenchymal Garnier, Alain U. Laval QC Bioprocessing—stem cells—culture Fradette, Julie 62 universitY/ institution LOEX Gassas, Adam Hospital for Sick Children U. Toronto ON Stem cells— hematopoietic Germain, Lucie LOEX U. Laval QC Stem cells—adult— epithelial appendiX 3A. RESEARCHERS IN ALPHABETICAL ORDER disease endoWed CHair Cancer url eMail No www.iric.ca/Recherche/Unites_Recherche/ Signalisation_vesiculaire.htm [email protected] Cancer No lambda.med.utoronto.ca/Emili.htm [email protected] Urological No www.sickkids.ca/AboutSickKids/Directory/People/F/ Walid-Farhat-landing-page.html [email protected] Reproduction—ovary No www.medicine.mcgill.ca/physio/staffpages/rfarookhi. htm [email protected] Musculoskeletal— bone and cartilage regeneration CRC in CellBiomaterial Biohybrid Systems www.usherbrooke.ca/gchimiquebiotech/personnel/ professeurs/nathalie-faucheux/ [email protected] Various No www.polymtl.ca/recherche/rc/en/professeurs/ details.php?NoProf=30&showtab=PUB [email protected] Neurological—spinal cord injury No www.uhnresearch.ca/researchers/profile. php?lookup=1781 [email protected] Musculoskeletal No orthopaedics.utoronto.ca/faculty/list/ferguson.htm [email protected] Neurological— neurodegenerative diseases, incl. Alzheimer’s CRC in Stem Cell Neurobiology www.cenum.umontreal.ca/membres/2_titulaires/ en_fernandes_k.html [email protected] Musculoskeletal No www.mtrl.ubc.ca/faculty_&_staff/fernlund.php [email protected] Various No www.med.uottawa.ca/bmi/eng/figeys.html [email protected] Musculoskeletal— bone No faculty-server.dentistry.dal.ca/datasystems/faculty_ website/Faculty_Staff_details.php?name=Mark_ Filiaggi§ion=presentations [email protected] Various No chemeng.queensu.ca/people/faculty/flynn/index.php [email protected] Musculoskeletal No www.loex.gc.ca [email protected] Musculoskeletal— bone No research.mae.carleton.ca/Faculty.html [email protected] Various No www.gch.ulaval.ca/agarnier/ [email protected] Cancer—leukemia No www.sickkids.ca/Research/LRG/LRG-members/dradam-gassas/index.html [email protected] Various, incl. cutaneous, cardiovascular, eye CRC in Stem Cell and Tissue Engineering www.cha.quebec.qc.ca/en/www/research/theresearch-centre/researchers/lucie-germain/index. html [email protected] 3 63 3 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE RESEARCHERS 3a. Cont’d universitY/ institution provinCe tYpe of regen. Med Geyer, Ronald U. Saskatchewan Sask Stem cells—cancer Ghanekar, Anand U. Toronto ON Stem cells—cancer Ghanem, Amyl Dalhousie U. NS Biomaterials—tissue engineering Giacomantonio, Carman A. Dalhousie U. NS Stem cells—cancer U. Montréal QC Tissue engineering Glass, Kathleen McGill U. QC Social science & humanities Golding, Michael C. U. Western Ontario (moved to Texas A&M U. June 2010) ON Stem cells—various— unspecified researCHer Giasson, Claude J. researCH institution LOEX affiliation Goulet, Francine LOEX U. Laval QC Tissue engineering— biomaterials, culture Gramolini, Anthony Orlando The Donnelly Centre, Banting and Best Department of Medical Research U. Toronto ON Stem cells— unspecified U. Toronto ON Stem cells— pluripotent— embryonic, induced pluripotent Grant, Denis Greenblatt, Jack The Donnelly Centre, Banting and Best Department of Medical Research U. Toronto ON Stem cells— unspecified Gregory-Evan, Kevin Vancouver Coastal Health Research Institute U. British Columbia BC Stem cells—embryonic U. Sherbrooke QC Stem cells—muscle progenitors Grenier, Guillaume 64 Griffith, May Sprott Centre for Stem Cell Research, Ottawa Health Research Institute U. Ottawa ON Biomaterials— scaffolds; Tissue engineering—stem cells Guidos, Cynthia Hospital for Sick Children U. Toronto ON Stem cells— hematopoietic Gutkowska, Jolanta Centre de recherche du Centre hospitalier de l’Université de Montréal U. Montréal QC Stem cells—embryonic Hamilton, Douglas U. Western Ontario ON Biomaterials; Tissue engineering Hansen, David U. Calgary AB Stem cells— unspecified appendiX 3A. RESEARCHERS IN ALPHABETICAL ORDER disease endoWed CHair Cancer url eMail No www.saskcancer.ca/Default.aspx?DN=a7fb7a713960-4787-b700-e2925d8a7c8a N/A Cancer—liver No www.uhnres.utoronto.ca/researchers/profile. php?lookup=2011 [email protected] Various No chemicalengineering.dal.ca/Faculty/Research/ Dr._A._Ghanem_.php [email protected] Cancer No generalsurgery.medicine.dal.ca/faculty. htm#Giacomantonio N/A Eye No mapageweb.umontreal.ca/giassonc/ [email protected] SSH: Ethics, legal No www.mcgill.ca/biomedicalethicsunit/faculty/glass/ [email protected] Embryogenesis No vetmed.tamu.edu/vtpp/directorydetail?userid=9942; vetmed.tamu.edu/rsl/faculty/michael-golding N/A Musculoskeletal No www.cha.quebec.qc.ca/en/www/research/theresearch-centre/researchers/francine-goulet/index. html [email protected] Cardiovascular CRC in Cardiovascular Proteomics and Molecular Therapeutics www.physiology.utoronto.ca/res/list/gramolini.htm [email protected] Cancer No www.pharmtox.utoronto.ca/faculty/directory/grant. htm [email protected] Various No tdccbr.med.utoronto.ca/members/jack_greenblatt. html [email protected] Eye Julia Levy B.C. Leadership Chair in Macular Research www.ophthalmology.ubc.ca/faculty_pages/kgregory-evans.html [email protected] Musculoskeletal— muscle No www.usherbrooke.ca/departement-chirurgie/ francais/recherche/professeurs-ayant-une-activitede-recherche/fiches-de-professeurs/guillaume [email protected] Eye No www.ohri.ca/profiles/griffith.asp [email protected] Cancer—leukemia No www.sickkids.ca/Research/Guidos-Lab/index.html [email protected] Cardiology No chumtl.qc.ca/crchum/chercheurs/chercheurs-liste/ gutkowska-j.en.html?mode=print [email protected] Dental No www.uwo.ca/anatomy/department/hamiltond/ dhamilton.html [email protected] Various No homepages.ucalgary.ca/~dhansen/ [email protected] 3 65 3 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE RESEARCHERS 3a. Cont’d universitY/ institution provinCe Harvey, Edward McGill U. QC Biomaterials; Tissue engineering—cells Hassell, John McMaster U. ON Stem cells—adult, cancer Hawke, Thomas McMaster U. ON Stem cells—muscle progenitor researCHer researCH institution Hazell, Alan Stewart Centre de recherché du Centre hospitalier de l’Université de Montréal U. Montréal QC Stem cells—neural Hebert, Marie-Josee Centre de recherche du Centre hospitalier de l’Université de Montréal U. Montréal QC Stem cells— mesenchymal Hedley, David William Ontario Cancer Institute, University Health Network U. Toronto ON Stem cells—cancer Helgason, Cheryl BC Cancer Agency U. British Columbia BC Stem cells—embryonic Hess, David John P. Robarts Research Institute U. Western Ontario ON Stem cells—bone marrow (mesenchymal, hematopoietic) Heveker, Nikolaus Hôpital Sainte-Justine U. Montréal QC Stem cells— hematopoietic Hicks, Geoffrey Cancer Care Manitoba—Institute of Cell Biology U. Manitoba MB Stem cells—embryonic Hill, David Lawson Health Research Institute, London Health Sciences Centre U. Western Ontario ON Stem cells—adult Hill, Richard Ontario Cancer Institute, University Health Network U. Toronto ON Stem cells—cancer Hoang, Trang Institute for Research in Immunology and Cancer U. Montréal QC Stem cells— hematopoietic Hoare, Todd McMaster U. ON Biomaterials Hoemann, Caroline École polytechnique de Montréal QC Tissue engineering— cells; Biomaterials U. British Columbia BC Stem cells— hematopoietic U. Manitoba MB Stem cells—cancer Hogge, Donna Terry Fox Laboratory, BC Cancer Agency Hombach-Klonisch, Sabine 66 tYpe of regen. Med Hoodless, Pamela Terry Fox Laboratory, BC Cancer Agency U. British Columbia BC Stem cells—embryonic Hope, Kristin Jill Stem Cell and Cancer Research Institute McMaster U. ON Stem cells— hematopoietic Horb, Markoe Institut de recherches cliniques de Montréal U. Montréal QC Stem cells— adult—endodermal progenitors appendiX 3A. RESEARCHERS IN ALPHABETICAL ORDER endoWed CHair url eMail Musculoskeletal— bone No www.medicine.mcgill.ca/orthopaedics/faculty.htm [email protected] Cancer No www.biology.mcmaster.ca/faculty/hassell/hassell. htm [email protected] Musculoskeletal— muscle No fhs.mcmaster.ca/pathology/contact_us/faculty/ faculty_bios/Hawke_000.html [email protected] Neurological—brain injury No www.chumtl.qc.ca/crchum/chercheurs/chercheursliste/hazell-as.en.html [email protected] Various—renal, cardiovascular No www.chumtl.qc.ca/crchum/chercheurs/chercheursliste/hebert-mj.fr.html [email protected] Cancer—cervical No www.uhnres.utoronto.ca/researchers/profile. php?lookup=2395 [email protected] Immunological— autoimmune No www.bccrc.ca/dept/et/personnel - content/seniorscientists/cheryl-helgason [email protected] Various— cardiovascular; Metabolic—diabetes No www.robarts.ca/david-hess [email protected] Various No www.chu-sainte-justine.org/research/chercheurs. aspx?ID_NOUVEAU=35430911&id_page=2432&id_ menu=2429 nikolaus.heveker@recherche-ste-justine. qc.ca Cancer CRC in Functional Genomics www.umanitoba.ca/institutes/manitoba_institute_ cell_biology/MICB/hicks_geoff.htm [email protected] Metabolic—diabetes No www.uwo.ca/physpharm/faculty/hill_david.html [email protected] Cancer—cervical No www.uhnres.utoronto.ca/researchers/profile. php?lookup=2445 [email protected] Cancer—leukemia CRC in Cell Differentiation and the Genetics of Acute Leukemias www.iric.ca/Recherche/Chercheurs/Hoang_T.html [email protected] Various No chemeng.mcmaster.ca/hoare.html [email protected] Musculoskeletal No www.polymtl.ca/recherche/rc/en/professeurs/ details.php?NoProf=347 [email protected] Cancer—leukemia No www.bccrc.ca/dept/terry-fox-laboratory/faculty/ Hogge [email protected] Cancer No www.umanitoba.ca/faculties/medicine/units/ anatomy/hombachks.html [email protected] Embryogenesis No www.bccrc.ca/dept/terry-fox-laboratory/faculty/dr.pamela-hoodless-phd [email protected] Cancer—leukemia No sccri.mcmaster.ca/hope_kristin.html [email protected] Metabolic—diabetes No www.montreal-diabetes-research-center.org/en/ horb/horb.asp [email protected] disease 3 67 3 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE RESEARCHERS 3a. Cont’d researCHer researCH institution universitY/ institution provinCe Hough, Margaret Sunnybrook Research Institute U. Toronto ON Stem cells— various—embryonic, hematopoietic Huang, Annie Hospital for Sick Children U. Toronto ON Stem cells—neural U. Calgary AB Stem cells—embryonic Huang, Sui Hughes, Timothy The Donnelly Centre—Banting and Best Department of Medical Research U. Toronto ON Stem cells—embryonic Hui, Chi-chung Hospital for Sick Children U. Toronto ON Stem cells—various— unspecified Humphries, Keith Terry Fox Laboratory, BC Cancer Agency U. British Columbia BC Stem cells— hematopoietic U. Calgary AB Tissue engineering— stem cells; Biomaterials U. Toronto ON Stem cells—embryonic Illes, Judy U. British Columbia BC Social science & humanities Ingram, Liz U. Alberta AB Social science & humanities U. Toronto ON Stem cells— hematopoietic Jackson, Michael U. Manitoba MB Stem cells—bone marrow Jervis, Eric U. Waterloo ON Bioprocessing—cell culture; Tissue engineering Hunter, Christopher Husain, Mansoor Iscove, Norman McEwen Centre for Regenerative Medicine, Toronto General Research Institute, University Health Network McEwen Centre for Regenerative Medicine, and Ontario Cancer Institute, University Health Network Jiang, Xiaoyan Terry Fox Laboratory, BC Cancer Agency U. British Columbia BC Stem cells— hematopoietic Jirik, Frank Southern Alberta Cancer Research Institute U. Calgary AB Stem cells—adult Johnson, James U. British Columbia BC Stem cells— pancreatic (islet) Johnston, James U. Saskatchewan Sask Tissue engineering— scaffolds Jolicoeur, Mario École polytechnique de Montréal QC Bioprocessing U. Montréal QC Stem cells—various— cancer/mammary McGill U. QC Tissue engineering Jolicoeur, Paul Jones, Elizabeth 68 tYpe of regen. Med Institut de recherches cliniques de Montréal appendiX 3A. RESEARCHERS IN ALPHABETICAL ORDER disease endoWed CHair Genetic url eMail No sunnybrook.ca/research/team/member. asp?t=11&m=83&page=172 margaret.hough@ sri.utoronto.ca Cancer—brain No www.sickkids.ca/AboutSickKids/Directory/People/H/ Annie-A-Huang.html [email protected] Hematological No www.bio.ucalgary.ca/contact/faculty/huang.html [email protected] Various No hugheslab.med.utoronto.ca/ [email protected] Neurological No www.sickkids.ca/AboutSickKids/Directory/People/H/ Chi-chung-Hu.html [email protected] Hematological— anemia, cancer No www.terryfoxlab.ca/people/khumphries/keith.aspx [email protected] Musculoskeletal—disc No www.eng.ucalgary.ca/resrch_mech/Mech_Hunter. htm [email protected] Cardiovascular No uhnres.utoronto.ca/researchers/profile. php?lookup=2610 [email protected] SSH: Ethics CRCin Neuroethics www.neuroethics.ubc.ca/National_Core_for_ Neuroethics/People.html [email protected] SSH: Social No www.artdesign.ualberta.ca/Faculty_and_Staff/ Faculty/Liz_Ingram.aspx [email protected] Cancer—leukemia No www.uhnresearch.ca/researchers/profile. php?lookup=2679 [email protected] Cardiology No www.umanitoba.ca/faculties/medicine/units/ pharmacology/faculty_members/index.html N/A Various No chemeng.uwaterloo.ca/faculty/jervis.html [email protected] Cancer—leukemia No www.terryfoxlab.ca/people/XJiang/xiaoyan.aspx [email protected] Cancer No www.sacri.ucalgary.ca/node/158 [email protected] Metabolic—diabetes No www.cellphys.ubc.ca/faculty_pages/johnson.html [email protected] Musculoskeletal No www.engr.usask.ca/faculty/Johnston_James.php [email protected] Various CRC in Applied Metabolic Engineering www.polymtl.ca/bio-p2/ [email protected] Cancer CRC in in Studies of Pathogenesis of Retrovirus— Induced Diseases en.wikipedia.org/wiki/Paul_Jolicoeur www.ircm. qc.ca/fr/recherche/statique/unite4.html [email protected] Cardiovascular CRC in Embryonic Biomechanics people.mcgill.ca/elizabeth.jones3/ [email protected] 3 69 3 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE RESEARCHERS 3a. Cont’d universitY/ institution provinCe tYpe of regen. Med Jones, Kim McMaster U. ON Biomaterials Joshi, Sadhna U. Toronto ON Stem cells— hematopoietic U. Toronto ON Stem cells—embryonic U. Ottawa ON Stem cells—embryonic U. Calgary AB Bioprocessing—stem cells, tissue culture Kamacheva, Eugenia U. Toronto ON Biomaterials Kamnasaran, Deepak U. Laval QC Stem cells—cancer researCHer Julius, Michael researCH institution Sunnybrook Research Institute Kaern, Mads Kallos, Michael Includes: Pharmaceutical Production Research Facility Kandel, Rita Samuel Lunenfeld Research Institute, Mount Sinai Hospital U. Toronto ON Tissue engineering— biomaterials, stem cells Kaplan, David Hospital for Sick Children U. Toronto ON Stem cells—cancer U. Manitoba MB Stem cells—neural U. British Columbia BC Stem cells— hematopoietic U. Toronto ON Stem cells— bone marrow— mesenchymal, hematopoietic Karimi-Abdolrezaee, Soheila Karsan, Aly BC Cancer Agency Keating, Armand 70 Keeley, Fred Hospital for Sick Children U. Toronto ON Biomaterials Keller, Gordon McEwen Centre for Regenerative Medicine and Ontario Cancer Institute, University Health Network U. Toronto ON Stem cells—embryonic Kelly, Kevin Francis Stem Cell and Cancer Research Institute McMaster U. ON Stem cells—embryonic Khan, Zia U. Western Ontario ON Stem cells—vascular Kieffer, Tim U. British Columbia BC Stem cells— gastrointestinal Kim, Seung Vancouver Coastal Health Research Institute U. British Columbia BC Stem cells—neural Kislinger, Thomas Ontario Cancer Institute, UHN U. Toronto ON Stem cells— unspecified appendiX 3A. RESEARCHERS IN ALPHABETICAL ORDER endoWed CHair url eMail Various, incl. immunological No chemeng.mcmaster.ca/jones.html [email protected] Infection—HIV No www.utoronto.ca/idmicro/ [email protected] Various, incl. immunological, cancer, infection No www.immunology.utoronto.ca/faculty/directory/ julius.htm [email protected] Various CRC in Systems Biology www.med.uottawa.ca/Associations/OISB/members/ member_mads_kaern.htm [email protected] Various No schulich.ucalgary.ca/resrch_chem/Chem_Kallos.htm [email protected] Various No www.chem.utoronto.ca/staff/EK/index.htm [email protected] Cancer—brain No kamnasaran.yolasite.com/ [email protected] Musculoskeletal No www.lunenfeld.ca/researchers/kandel [email protected] Cancer CRC in in Cancer and Neuroscience www.sickkids.ca/AboutSickKids/Directory/People/K/ David-Kaplan.html [email protected] Neurological—spinal cord injury No www.mich.ca/index.php?page=9&id=64 [email protected] Cancer—leukemia No www.bccrc.ca/dept/cmsgsc/faculty/dr-aly-karsanmd/?searchterm=Karsan [email protected] Cancer— hematological Epstein Chair in Cell Therapy and Transplantation www.armandkeating.com [email protected] Cardiovascular Heart and Stroke Foundation of Ontario—Robert M. Freedom Chair in Cardiovascular Science www.sickkids.ca/AboutSickKids/Directory/People/K/ Frederick-Keeley-staff-profile.html [email protected] Various, incl. hematological, cardiovascular CRC in Embryonic Stem Cell Biology www.uhn.ca/donate/tgwh/site/mcewen/bio_keller. asp [email protected] Various, incl. cutaneous, cancer No sccri.mcmaster.ca/kelly_kevin.html [email protected] Various No www.uwo.ca/pathol/faculty/khan.html [email protected] Metabolic—diabetes No www.cellphys.ubc.ca/faculty_pages/kieffer.html [email protected] Neurological No www.brain.ubc.ca/people.htm#K [email protected] Cardiovascular No www.uhnres.utoronto.ca/researchers/profile. php?lookup=12469 [email protected] disease 3 71 3 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE RESEARCHERS 3a. Cont’d researCHer researCH institution universitY/ institution provinCe tYpe of regen. Med Klonisch, Thomas CancerCare Manitoba U. Manitoba MB Stem cells—cancer Knoppers, Bartha McGill U. QC Social science & humanities Ko, Frank U. British Columbia BC Tissue engineering— scaffolds Korbutt, Gregory Alberta Diabetes Institute U. Alberta AB Tissue engineering— stem cells, islet; Transplantation Kothary, Rashmi K. Ottawa Hospital Research Institute U. Ottawa ON Stem cells—embryonic Kreplak, Laurent Dalhousie U. NS Biomaterials— scaffolds Krieger, Charles Simon Fraser U. BC Stem cells—bone marrow Krylov, Sergey N. York U. ON Stem cells— unspecified Krystal, Gerald Terry Fox Laboratory, BC Cancer Agency U. British Columbia BC Stem cells— hematopoietic Kuruvilla, John Ontario Cancer Institute, University Health Network U. Toronto ON Stem cells— unspecified Kwon, Brian U. British Columbia BC Stem cells— unspecified Labbé, Jean-Claude U. Montréal QC Stem cells— unspecified U. Laval QC Tissue engineering Lagace, Diane U. Ottawa ON Stem cells— unspecified Lajoie, Gilles U. Western Ontario ON Stem cells—embryonic Langelier, Eve U. Sherbrooke QC Tissue engineering; Biomaterials U. British Columbia BC Stem cells—various— hematopoietic, induced pluripotent, embryonic U. Toronto ON Stem cells—neural Lacroix, Dan Lansdorp, Peter LOEX Terry Fox Laboratory, BC Cancer Agency Laposa, Rebecca 72 Larouche, Danielle LOEX U. Laval QC Stem cells— unspecified Leavitt, Blair Centre for Molecular Medicine & Therapeutics U. British Columbia BC Stem cells— unspecified appendiX 3A. RESEARCHERS IN ALPHABETICAL ORDER disease endoWed CHair Cancer url eMail No www.umanitoba.ca/faculties/medicine/units/ anatomy/klonischt.html [email protected] SSH: Ethics, law, policy No academic.mcgill.ca/newfac/profiles/2009/by-name/ knoppers.htm [email protected] Various CRC in in Advanced Fibrous Materials afml.ampel.ubc.ca/ProfKo.php [email protected] Metabolic—diabetes; Other No www.adi.med.ualberta.ca/Home/Research/ PrincipalInvestigators/Bio/korbutt.cfm [email protected] Various, incl. neurological, cardiovascular University Health Research Chair in Neuromuscular Disorders www.ohri.ca/profiles/kothary.asp [email protected] Various No fizz.phys.dal.ca/~kreplak/?page_id=14 [email protected] Neurological No www2.fas.sfu.ca/kin/Faculty/Krieger.html [email protected] Various CRC in Bioanalytical Chemistry www.chem.yorku.ca/profs/krylov/ [email protected] Cancer No www.bccrc.ca/dept/terry-fox-laboratory/faculty/ Krystal [email protected] Cancer— hematological No N/A [email protected] Neurological—spinal cord injury No www.orthosurgery.ubc.ca/faculty_bios/kwon.html [email protected] Cancer CRC in Cellular Division and Differentiation www.iric.ca/Recherche/Chercheurs/Labbe_JC.html [email protected] Various No www.cha.quebec.qc.ca/en/www/research/theresearch-centre/researchers/dan-lacroix/index.html [email protected] Neurological No www.med.uottawa.ca/NSC/eng/lagace.htm [email protected] Various; Proteomics No www.biochem.uwo.ca/fac/lajoie/ [email protected] Musculoskeletal No www.usherbrooke.ca/gmecanique/departement/ personnel/professeurs/eve-langelier/ [email protected] Cancer, other No www.bccrc.ca/dept/terry-fox-laboratory/faculty/ Lansdorp [email protected] Neurological No www.pharmtox.utoronto.ca/faculty/directory/laposa. htm [email protected] Various No www.cha.quebec.qc.ca/en/www/research/theresearch-centre/researchers/danielle-larouche/ index.html [email protected] Neurological No www.cmmt.ubc.ca/research/investigators/leavitt/lab [email protected] 3 73 3 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE RESEARCHERS 3a. Cont’d universitY/ institution provinCe tYpe of regen. Med McGill U. QC Stem cells—neural Lee, Patrick WK Dalhousie U. NS Stem cells—cancer Lefebvre, Louis U. British Columbia BC Stem cells—embryonic Legge, Raymond U. Waterloo ON Tissue engineering— scaffolds Leibing, Annette U. Montréal QC Social science & humanities Lemmens, Trudo U. Toronto ON Social science & humanities Leroux, Therese U. Montréal QC Social science & humanities researCHer researCH institution Lecanu, Laurent The Research Institute of the McGill University Health Centre Lessard, Julie Institute for Research in Immunology and Cancer U. Montréal QC Stem cells— hematopoietic Levesque, Eric Centre hospitalier de l’Université Laval U. Laval QC Stem cells— hematopoietic Levin, Leonard Centre de recherche de l’Hôpital Maisonneuve-Rosemont U. Montréal QC Stem cells—neural Levy, Gary Toronto General Research Institute, University Health Network U. Toronto ON Stem cells—various— unspecified Lewis, James Franklin Lawson Health Research Institute, London Health Sciences Centre U. Western Ontario ON Stem cells—bone marrow U. Guelph ON Stem cells—dermal U. Toronto ON Stem cells— hematopoietic Queen’s U. ON Stem cells— unspecified U. Montréal QC Stem cells— mesenchymal U. British Columbia BC Stem cells—embryonic Li, Julang Li, Ren-Ke McEwen Centre for Regenerative Medicine, Toronto General Research Institute, University Health Network Lilicrap, David Ly, Hung Montreal Heart Institute Lynn, Francis Mak, Tak Ontario Cancer Institute, University Health Network U. Toronto ON Stem cells— mesenchymal Marra, Marco BC Cancer Agency, Genome Sciences Centre U. British Columbia BC Stem cells—embryonic U. Manitoba MB Stem cells—various— unspecified U. Montréal QC Stem cells—various— adult Marshall, Aaron Massie, Bernard 74 Associated with National Research Council—Biotechnology Research Institute appendiX 3A. RESEARCHERS IN ALPHABETICAL ORDER disease endoWed CHair Neurological url eMail No muhc.ca/research/researcher/laurent-lecanu-mscphd N/A Cancer No microbiology.medicine.dal.ca/people/plee/ [email protected] Genetic CRC in Genomic Imprinting www.medgen.ubc.ca/research/research_faculty/ llefebvre.htm [email protected] Various No chemeng.uwaterloo.ca/faculty/legge.html [email protected] SSH: Social No www.meos.qc.ca [email protected] SSH: Law No www.law.utoronto.ca/faculty_content.asp?profile=33 &cType=facMembers&itemPath=1/3/4/0/0 [email protected] SSH: Policy No www.crdp.umontreal.ca/en/chercheurs/leroux_ therese/index.html [email protected] Cancer— hematological CRC in Molecular Genetics of Stem Cell Hematopoiesis www.iric.ca/Recherche/Chercheurs/Lessard_FR.htm [email protected] Cancer No www.pharmacogenomics.pha.ulaval.ca/sgc/lang/ en_CA/pid/10271 [email protected] Eye CRC in Ophtalmology and Vision Sciences recherche.maisonneuve-rosemont.org/en-ca/ research/our-research-investigators/levin-leonard. html [email protected] Various, incl. immunological No www.uhnres.utoronto.ca/researchers/profile. php?lookup=3442 [email protected] Immunological— inflammation No dom.lhsc.on.ca/dom/divisions/respirology/jl.htm [email protected] Reproduction—female; Other No www.aps.uoguelph.ca/?action=faculty&id=104 [email protected] Cardiovascular, cardiology CRC in Cardiac Regeneration www.mcewencentre.com/bio_li.asp [email protected] Hematological— hemophilia No www.path.queensu.ca/labs/lillicrap/ [email protected] Cardiology No www.icm-mhi.org/en/medecine-prof.html [email protected] Metabolic—diabetes No www.surgery.ubc.ca/faculty/fclynn.html [email protected] Cancer No www.uhnresearch.ca/researchers/profile. php?lookup=3816 [email protected] Various No www.bcgsc.ca/faculty/mmarra/research/view [email protected] Various CRC in Molecular Immunology umanitoba.ca/faculties/medicine/units/immunology/ marshallbio.html [email protected] Various, incl. hematological— hemophilia No www.universadecouvrir.gc.ca/page/index. php?p=195&l=e [email protected] 3 75 3 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE RESEARCHERS 3a. Cont’d researCHer researCH institution Matyas, John Robert McBurney, Michael Ottawa Hospital Research Institute McDonald, Michael McElwee, Kevin Vancouver Coastal Health Research Institute McGann, Locksley Earl provinCe tYpe of regen. Med U. Calgary AB Stem cells—embryonic U. Ottawa ON Stem cells—embryonic U. British Columbia BC Social science & humanities U. British Columbia BC Stem cells— mesenchymal U. Alberta AB Technology— Stem cells— cryopreservation McGuigan, Alison Institute of Biomaterials and Biomedical Engineering U. Toronto ON Tissue engineering— cells McInnes, Roderick Jewish General Hospital, Lady Davis Institute McGill U. QC Stem cells—various— embryonic, adult McKerlie, Colin Samuel Lunenfeld Research Institute, Mount Sinai Hospital U. Toronto ON Stem cells—various— unspecified McNagny, Kelly Biomedical Research Centre U. British Columbia BC Stem cells— hematopoietic Meakin, Susan John P. Robarts Research Institute U. Western Ontario ON Stem cells— unspecified Megeney, Lynn Sprott Centre for Stem Cell Research, Ottawa Health Research Institute U. Ottawa ON Stem cells— myocardial Mendez, Ivar Dalhousie U. NS Stem cells—fetal Menon, Devidas U. Alberta AB Social science & humanities Mequanint, Kibret U. Western Ontario ON Tissue engineering— scaffolds Merrifield, Peter U. Western Ontario ON Stem cells—muscle U. Calgary AB Stem cells—adult— endogenous progenitor U. Alberta AB Stem cells—embryonic Metz, Luanne Associated with Hotchkiss Brain Institute Michalak, Marek S. 76 universitY/ institution Midha, Rajiv Associated with Hotchkiss Brain Institute U. Calgary AB Stem cells—dermal Miller, Freda McEwen Centre for Regenerative Medicine, Toronto General Research Institute, University Health Network U. Toronto ON Stem cells—various— dermal, neural Minden, Mark David Ontario Cancer Institute, University Health Network U. Toronto ON Stem cells— hematopoietic appendiX 3A. RESEARCHERS IN ALPHABETICAL ORDER disease endoWed CHair url eMail Musculoskeletal No www.cell.ucalgary.ca/j_matyas.html [email protected] Various—aging, cancer No www.ohri.ca/profiles/mcburney.asp [email protected] SSH: Ethics No www.ethics.ubc.ca/index.php?p=personweb2 [email protected] Cutaneous No www.hairlaboratory.com/hair-laboratory-team/kevinmcelwee.html [email protected] Various No www.experts.ualberta.ca/expert.cfm?id=40321 [email protected] Various No www.ibbme.utoronto.ca/Page502.aspx [email protected] Various, incl. eye Alva Chair in Human Genetics; CRC in Neurogenetics www.ladydavis.ca/en/rodmcinnes [email protected] Various No www.sickkids.ca/AboutSickKids/Directory/People/M/ Colin-McKerlie.html [email protected] Various— allergy, asthma, cardiovascular, hematological, neurological No www.brc.ubc.ca/drupal5/node/39 [email protected] Neurological No www.robarts.ca/smeakin/ [email protected] Cardiovascular Mach Gaensslen Chair in Cardiac Research www.ohri.ca/profiles/megeney.asp [email protected] Neurological No neurosurgery.medicine.dal.ca/labs.htm [email protected] SSH: Policy No www.publichealth.ualberta.ca/research/ researchers_supersivors/faculty/menon.aspx [email protected] Various No www.eng.uwo.ca/research/compendium/faculty/ kmequanint.htm [email protected] Musculoskeletal No www.uwo.ca/anatomy/department/merrifieldp/ pmerrifield.html [email protected] Neurological—multiple sclerosis No www.hbi.ucalgary.ca/members/metz [email protected] [email protected] Cardiovascular No www.biochem.ualberta.ca/faculty_detail.php?id=13 [email protected] Neurological No www.hbi.ucalgary.ca/members/midha [email protected] Neurological, incl. spinal cord injury CRC in Developmental Neurobiology www.sickkids.ca/AboutSickKids/Directory/People/M/ Freda-Miller.html [email protected] Cancer—leukemia No www.uhnresearch.ca/researchers/profile. php?lookup=4159 [email protected] 3 77 3 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE RESEARCHERS 3a. Cont’d researCHer researCH institution universitY/ institution provinCe Moffat, Jason The Donnelly Centre U. Toronto ON Stem cells— pluripotent— induced pluripotent Mollica, Luigina Centre de recherche de l’Hôpital Maisonneuve-Rosemont U. Montréal QC Stem cells— hematopoietic Moroy, Tarik Institut de recherches cliniques de Montréal U. Montréal QC Stem cells— hematopoietic Morris, Quaid The Donnelly Centre, Banting and Best Department of Medical Research U. Toronto ON Stem cells—embryonic U. Toronto ON Stem cells—neural Morshead, Cindi Moulin, Véronique LOEX U. Laval QC Tissue engineering— stem cells Munoz Risueno, Ruth Stem Cell and Cancer Research Institute McMaster U. ON Stem cells— hematopoietic Mwale, Fackson Jewish General Hospital, Lady Davis Institute McGill U. QC Stem cells— mesenchymal Nagano, Makoto The Research Institute of the McGill University Health Centre McGill U. QC Stem cells— germline—sperm Nagy, Andras Samuel Lunenfeld Research Institute, Mount Sinai Hospital and McEwen Centre for Regenerative Medicine, University Health Network U. Toronto ON Stem cells—various— pluripotent— induced pluripotent, embryonic; Somatic Nanci, Antonio U. Montréal QC Tissue engineering— cells; Biomaterials Nazhat, Showan McGill U. QC Biomaterials— scaffolds; Tissue engineering U. Toronto ON Stem cells—cancer U. Ottawa ON Stem cells— unspecified Neel, Benjamin Ontario Cancer Institute, University Health Network Nemer, Mona Nevill, Thomas Vancouver Coastal Health Research Institute U. British Columbia BC Stem cells— hematopoietic O’Brien, Catherine Adell Ontario Cancer Institute, University Health Network U. Toronto ON Stem cells—cancer Ohasi, Pamela Sumiko Ontario Cancer Institute, University Health Network U. Toronto ON Stem cells— mesenchymal U. Toronto ON Stem cells—embryonic U. Toronto ON Stem cells—various— embryonic, cancer Opas, Michal J. Paige, Christopher 78 tYpe of regen. Med Ontario Cancer Institute, University Health Network appendiX 3A. RESEARCHERS IN ALPHABETICAL ORDER disease endoWed CHair url eMail Various No tdccbr.med.utoronto.ca/members/jason_moffat.html [email protected] Various No recherche.maisonneuve-rosemont.org/en-ca/ research/our-research-investigators/mollica-luigina. html [email protected] Cancer— hematological CRC in Hematopoiesis and Immune Cell Differentiation www.ircm.qc.ca/microsites/moroy/en/ [email protected] Various No thedonnellycentre.utoronto.ca/members/quaid_ morris.html [email protected] Neurological, other No www.utoronto.ca/morsheadlab/ [email protected] Various No www.cha.quebec.qc.ca/en/www/research/theresearch-centre/researchers/veronique-moulin/ index.html [email protected] Cancer—leukemia No sccri.mcmaster.ca/risueno_ruth_munoz.html [email protected] Musculoskeletal—disc No www.ladydavis.ca/en/facksonmwale [email protected] Reproduction—male No people.muhc.ca/makoto.nagano/ [email protected] Various, incl. cancer CRC in Stem Cells and Regeneration www.lunenfeld.ca/researchers/nagy [email protected] Musculoskeletal No www.nancicalcifiedtissuegroup.com/ananci.htm [email protected] Musculoskeletal No www.mcgill.ca/dentistry/research/nazhat/ [email protected] Cancer—ovarian No www.uhnresearch.ca/researchers/profile. php?lookup=14776 [email protected] Cardiology No web5.uottawa.ca/admingov/biography_4.html N/A Cancer No www.leukemiabmtprogram.org/general_information/ about_us/our_doctors/nevill.html [email protected] Cancer—colorectal No generalsurgery.utoronto.ca/faculty/list/obrien.htm [email protected] Cancer CRC in Autoimmunity and Tumour Immunity www.uhnres.utoronto.ca/researchers/profile. php?lookup=4520 [email protected] Various— musculoskeletal, cardiovascular No icarus.med.utoronto.ca/patho/faculty. asp?FacultyID=349 [email protected] Cancer No www.uhnres.utoronto.ca/researchers/profile. php?lookup=4608 [email protected] 3 79 3 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE RESEARCHERS 3a. Cont’d universitY/ institution provinCe tYpe of regen. Med Pang, Stephen Queen’s U. ON Stem cells—embryonic Paquin, Joanne U. Québec à Montréal QC Stem cells—various embryonic, adult Parise, Gianni McMaster U. ON Stem cells—muscle Park, Edward U. Victoria BC Technology—stem cells—cell sorting Pasumarthi, Kishore Babu S. Dalhousie U. NS Stem cells—cardiac progenitor researCHer researCH institution Pelletier, Marc New Brunswick Heart Centre New Brunswick Heart Centre NB Stem cells— mesenchymal Perkins, Theodore Sprott Center for Stem Cell Research, Ottawa Health Research Institute U. Ottawa ON Stem cells—various— unspecified Pilarski, Linda U. Alberta AB Stem cells—cancer Pilliar, Robert U. Toronto ON Biomaterials; Tissue engineering Pilon, Nicolas U. Québec à Montréal QC Stem cells—embryonic Piret, James Michael Smith Laboratories U. British Columbia BC Technology— stem cells, incl. hematopoietic—high throughput analysis; Bioprocessing—cell culture Podor, Thomas iCapture U. British Columbia BC Stem cells— hematopoietic (bone marrow) Post, Martin Hospital for Sick Children U. Toronto ON Stem cells—embryonic U. Western Ontario ON Stem cells— unspecified U. Laval QC Tissue engineering; Biomaterials McGill U. QC Biomaterials; Tissue engineering Postovit, Lynne-Marie Pouliot, Roxane LOEX Prakash, Satya Prato, Frank Lawson Health Research Institute, London Health Sciences Centre U. Western Ontario ON Stem cells—adult— endothelial progenitor Puri, Mira Sunnybrook Research Institute U. Toronto ON Stem cells—embryonic Putnins, Edward U. British Columbia BC Stem cells—bone marrow Puymirat, Jack U. Laval QC Stem cells—amniotic U. British Columbia BC Stem cells—bone marrow Qayumi, Karim 80 Vancouver Coastal Health Research Institute appendiX 3A. RESEARCHERS IN ALPHABETICAL ORDER disease endoWed CHair url eMail Cardiology No anatomy.queensu.ca/faculty/pang.cfm [email protected] Musculoskeletal No www.biomed.uqam.ca/spip.php?rubrique60 [email protected] Musculoskeletal No www.science.mcmaster.ca/kinesiology/people/ faculty/291-Gianni Parise.html [email protected] Various No N/A [email protected] Cardiology No pharmacology.medicine.dal.ca/about/people/faculty_ detail.cfm?ID_People=105 [email protected] Cardiology No www.ctsnet.org/home/mpelletier [email protected] Various No www.perkinslab.ca/ [email protected] Cancer—multiple myeloma CRC in Biomedical Nanotechnology www.oncology.med.ualberta.ca/faculty/ facultymember.cfm?id=24 [email protected] Musculoskeletal— bone; Dental No www.utoronto.ca/dentistry/facultyresearch/ facultyprofiles/pilliar_robert.html [email protected] Neurological No www.biomed.uqam.ca/spip.php?rubrique87/ [email protected] Various No www.msl.ubc.ca/faculty/piret [email protected] Cardiology No www.icapture.ubc.ca/who/who_bios_tom_podor. shtml [email protected] Respiratory No www.sickkids.ca/AboutSickKids/Directory/People/P/ Martin-Post.html [email protected] Cancer No www.uwo.ca/anatomy/department/postovitl/ lpostovit.html [email protected] Musculoskeletal No www.pha.ulaval.ca/sgc/pid/4929 [email protected] Cancer No www.bmed.mcgill.ca/BTCTRL/ [email protected] Cardiology No www.uwo.ca/radnuc/radiologists/prato.html [email protected] Embryogenesis No medbio.utoronto.ca/faculty/puri.html [email protected] Musculoskeletal No www.dentistry.ubc.ca/directory/faculty/detail. asp?user_id=24&from_directory=1 [email protected] Mysculoskeletal myotonic dystrophy No jpuymiratlab.crchul.ulaval.ca/ [email protected] Cardiology No www.researchers.vchri.ca/s/Researchers. asp?ReportID=40705&_Type=ResearchersDatabase&_Title=Qayumi-Dr.-A.-Karim [email protected] 3 81 3 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE RESEARCHERS 3a. Cont’d universitY/ institution provinCe tYpe of regen. Med Quinn, Thomas McGill U. QC Tissue engineering Radisic, Milica U. Toronto ON Tissue engineering— scaffolds, cells; Stem cells—angiogenic progenitor Rafuse, Victor Dalhousie U. NS Stem cells— pluripotent— embryonic, induced pluripotent; Neural Rajotte, Raymond V. U. Alberta AB Stem cells— pancreatic McGill U. QC Stem cells—cancer Ramsay, Bruce Queens U. ON Tissue engineering— scaffolds Rancourt, Derrick U. Calgary AB Stem cells— pluripotent— embryonic, induced pluripotent U. Manitoba MB Stem cells—cancer Rastegar, Mojgan U. Manitoba MB Stem cells— pluripotent—induced pluripotent, embryonic Reilly, Raymond Matthew U. Toronto ON Stem cells—cancer Reinhardt, Dieter McGill U. QC Tissue engineering— biomaterials, cells researCHer Rak, Janusz Raouf, Afshin researCH institution The Research Institute of the McGill University Health Centre Cancer Care Manitoba—Institute of Cell Biology Reudelhuber, Timothy Luther Institut de recherches cliniques de Montréal U. Montréal QC Stem cells— unspecified Rivest, Serge Centre hospitalier de l’Université Laval U. Laval QC Stem cells—bone marrow McGill U. QC Stem cells—germline Robaire, Bernard Robert, François Institut de recherches cliniques de Montréal U. Montréal QC Stem cells— hematopoietic Rogers, Ian Samuel Lunenfeld Research Institute, Mount Sinai Hospital U. Toronto ON Stem cells—various— cord blood, induced pluripotent, bone marrow Rosenberg, Lawrence The Research Institute of the McGill University Health Centre McGill U. QC Stem cells— pancreatic U. British Columbia BC Stem cells—neural U. Toronto ON Stem cells—embryonic Roskams, Jane Rossant, Janet 82 Hospital for Sick Children appendiX 3A. RESEARCHERS IN ALPHABETICAL ORDER disease endoWed CHair Musculoskeletal— cartilage, ligaments url eMail CRC in Soft Tissue Biophysics people.mcgill.ca/thomas.quinn/ [email protected] Cardiology No www.labs.chem-eng.utoronto.ca/radisic/principalinvestigator/ [email protected] Neurological, including Parkinson’s, ALS No www.anatomy.dal.ca/Rafuse/index.htm [email protected] Metabolic—diabetes No www.adi.med.ualberta.ca/Home/Research/ PrincipalInvestigators/Bio/rajotte.cfm [email protected] Cancer—brain No people.muhc.ca/janusz.rak/ [email protected] Various No chemeng.queensu.ca/people/adjunct_Instructors/ bruce-ramsay/index.php [email protected] Musculoskeletal No people.ucalgary.ca/~derlab/index.html [email protected] Cancer—breast No www.umanitoba.ca/institutes/manitoba_institute_ cell_biology/MICB/Rauof Afshin.htm [email protected] Neurological, cancer—brain No umanitoba.ca/faculties/medicine/units/biochem/ faculty/facultylists.html [email protected] Cancer—leukemia No /www.uhnresearch.ca/researchers/profile. php?lookup=5062 [email protected] Musculoskeletal CRC in Extracellular Matrix Biology www.mcgill.ca/dentistry/research/reinhardt/ [email protected] Cardiovascular No www.medicine.mcgill.ca/expmed/staff/reudelhuber_ timothy.htm [email protected] Neurological No www.crchuq.ulaval.ca/en/research/researchers/4681 [email protected] Reproduction—male; Other No www.medicine.mcgill.ca/pharma/robairelab/ [email protected] Hematological No www.ircm.qc.ca/microsites/francoisrobert/en/ [email protected] Various, including diabetes No www.lunenfeld.ca/researchers/rogers [email protected] Metabolic—diabetes No www.montreal-diabetes-research-center.org/en/ rosenberg/rosenberg.asp [email protected] Neurological— olfactory No www.zoology.ubc.ca/person/roskams [email protected] Embryogenesis Lombard Insurance Chair www.sickkids.ca/aboutsickkids/directory/people/r/ janet-rossant.html [email protected] 3 83 3 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE RESEARCHERS 3a. Cont’d Rossi, Fabio Biomedical Research Centre U. British Columbia BC Stem cells— hematopoietic Rottapel, Robert Ontario Cancer Institute, University Health Network U. Toronto ON Stem cells— hematopoietic Roy, Denis-Claude Centre de recherche de l’Hôpital Maisonneuve-Rosemont U. Montréal QC Stem cells—cancer Roy, Jean Centre de recherche de l’Hôpital Maisonneuve-Rosemont U. Montréal QC Stem cells— hematopoietic Rudnicki, Michael Sprott Centre for Stem Cell Research, Ottawa Hospital Research Institute U. Ottawa ON Stem cells—various— embryonic, muscle, other adult Ruel, Marc University of Ottawa Heart Institute U. Ottawa ON Stem cells—various— mesenchymal and endothelial progenitor; Tissue engineering Sabourin, Luc Ottawa Hospital Research Institute U. Ottawa ON Stem cells—various— embryonic, adult Santamaria, Pere U. Calgary AB Stem cells—embryonic Santerre, Paul U. Toronto ON Tissue engineering— biomaterials, cells U. Montréal QC Stem cells—various— hematopoietic, embryonic U. Laval QC Stem cells—muscle Institute for Research in Immunology and Cancer Savard, Pierre provinCe tYpe of regen. Med researCH institution Sauvageau, Guy 84 universitY/ institution researCHer Schimmer, Aaron Ontario Cancer Institute, University Health Network U. Toronto ON Stem cells—cancer Schrader, John W. Biomedical Research Centre U. British Columbia BC Stem cells— hematopoietic Schuh, Andre Ontario Cancer Institute, University Health Network U. Toronto ON Stem cells—embryonic Schultz, Kirk Child & Family Research Institute U. British Columbia BC Stem cells— hematopoietic Schuurmans, Carol Associated with Hotchkiss Brain Institute U. Calgary AB Stem cells— unspecified appendiX 3A. RESEARCHERS IN ALPHABETICAL ORDER disease endoWed CHair url eMail Various CRC in Regenerative Medicine (previously) www.brc.ubc.ca/drupal5/node/73 [email protected] Various No www.uhnres.utoronto.ca/researchers/profile. php?lookup=5182 [email protected] Cancer—leukemia No recherche.maisonneuve-rosemont.org/en-ca/ research/our-research-investigators/roy-denisclaude.html [email protected] Cancer—leukemia Chair Industrielle— Alliance/ Université de Montréal Foundation on Leukemia Research www.sct-hmr.org/en/jroy.php [email protected] Various, incl. neuromuscular CRC in Molecular Genetics www.ohri.ca/profiles/rudnicki.asp [email protected] Cardiology Cardiac Surgery Research Chair www.ottawaheart.ca/misc/marc-ruel.htm [email protected] Various No www.ohri.ca/profiles/sabourin_summ.asp [email protected] Various, incl. immunological, metabolic—diabetes No medicine.ucalgary.ca/research/chairs/santamaria/cv [email protected] Cardiovascular No www.utoronto.ca/dentistry/facultyresearch/ facultyprofiles/santerre.html [email protected] [email protected] Cancer— hematological; Other CRC in the Molecular Genetics of Normal and Cancer Cells www.iric.ca/Recherche/Chercheurs/Sauvageau_G. html [email protected] Various No www.crchuq.ulaval.ca/recherche/chercheurs/4641 [email protected] Cancer—leukemia No www.uhnresearch.ca/researchers/profile. php?lookup=5351 [email protected] Immunological— immunodeficiency No www.brc.ubc.ca/drupal5/node/36 [email protected] Hematological— hemophilia No medbio.utoronto.ca/faculty/schuh.html [email protected] Cancer—leukemia No www.cfri.ca/our_research/researchers/search_ researchers/researcher_detail.asp?ID=119 [email protected] Neurological—stroke, spinal cord injury, eye No www.ucalgary.ca/bmb/schuurmans [email protected] 3 85 3 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE RESEARCHERS 3a. Cont’d researCHer researCH institution universitY/ institution provinCe Sefton, Michael The Donnelly Centre U. Toronto ON Tissue engineering— biomaterials, cells Seguin, Cheryle U. Western Ontario ON Stem cells—various— pluripotent, neural Sen, Arindom U. Calgary AB Bioprocessing—stem cells—adult U. Toronto ON Stem cells— mesenchymal McMaster U. ON Biomaterials U. Toronto ON Tissue engineering: Biomaterials— scaffolds; Stem cells U. Toronto ON Technology— high throughput screening; Stem cells—mesenchymal, cord blood; Tissue engineering McMaster U. ON Stem cells—cancer U. Ottawa ON Stem cells—embryonic Shaw, Patricia Ann Ontario Cancer Institute, University Health Network Sheardown, Heather Shoichet, Molly McEwen Centre for Regenerative Medicine, Toronto General Research Institute, University Health Network Simmons, Craig Singh, Sheila Stem Cell and Cancer Research Institute Skerjanc, Ilona Sylvia Slack, Ruth Ottawa Hospital Research Institute U. Ottawa ON Stem cells— unspecified Smith, Clayton Terry Fox Laboratoy, BC Cancer Agency U. British Columbia BC Stem cells— hematopoietic U. Montréal QC Stem cells—embryonic U. British Columbia BC Stem cells— hematopoietic U. Toronto ON Stem cells—various— pluripotent—induced pluripotent, embryonic; Mesenchymal Smith, Lawrence C. Song, Kevin Vancouver Coastal Health Research Institute Stanford, William 86 tYpe of regen. Med Stanisz, Greg Sunnybrook Research Institute U. Toronto ON Stem cells— unspecified Stewart, Alexandre University of Ottawa Heart Institute U. Ottawa ON Stem cells—cardiac Stewart, Duncan Sprott Centre for Stem Cell Research, Ottawa Health Research Institute U. Ottawa ON Stem cells—adult Stifani, Stefano Montreal Neurological Institute McGill U. QC Stem cells—embryonic appendiX 3A. RESEARCHERS IN ALPHABETICAL ORDER disease endoWed CHair url eMail Various Michael E. Charles Chair in Chemical Engineering alumni.utoronto.ca/s/731/index. aspx?sid=731&gid=36&pgid=2135; tdccbr.med. utoronto.ca/members/michael_sefton.html [email protected] Various, incl. metabolic, musculoskeletal, embryogenesis No www.uwo.ca/physpharm/faculty/seguin_cheryle.html cheryle.seguin@ schulich.uwo.ca Various No www.schulich.ucalgary.ca/chemical/ArindomSen [email protected] Cancer No www.uhnres.utoronto.ca/researchers/profile. php?lookup=5485 [email protected] Various—eye, cardiovascular No chemeng.mcmaster.ca/sheardown.html [email protected] Various—neurological: Spinal cord injury, eye; Cancer CRC in Tissue Engineering www.mcewencentre.com/bio_shoichet.asp [email protected] [email protected] Various—cardiology; Musculoskeletal— bone CRC in Mechanobiology www.mie.utoronto.ca/staff/profiles/simmons/ [email protected] Cancer—brain CRC in Human Cancer Stem Cell Biology sccri.mcmaster.ca/singh_sheila.html [email protected] Various— cardiovascular, musculoskeletal No www.med.uottawa.ca/bmi/eng/skerjanc.html [email protected] Neurological No www.med.uottawa.ca/ruthslack/ [email protected] Cancer— hematological CRC in Cell Therapies www.terryfoxlab.ca/people/csmith/clayton.aspx [email protected] Embryogenesis No www.medvet.umontreal.ca/crra/index.php/ chercheurs/lawrence-c-smith [email protected] Cancer—lymphoma No www.vch.ca/bmt/public/referral/attending.htmlwww. leukemiabmtprogram.org/general_information/ about_us/our_doctors/song.html [email protected] Various, incl. musculoskeletal— osteoporosis CRC in Stem Cell Bioengineering and Functional Genomics www.wlstanfordlab.com/index.php [email protected] Neurological No medbio.utoronto.ca/faculty/stanisz.html [email protected] Cardiology No www.ottawaheart.ca/misc/alexandre-stewart.htm [email protected] Cardiovascular No www.ohri.ca/profiles/stewart.asp [email protected] Neurological—ALS No www.mni.mcgill.ca/neuro_team/neuronal_survival/ stefano_stifani/ [email protected] 3 87 3 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE RESEARCHERS 3a. Cont’d researCHer researCH institution Sun, Yu provinCe tYpe of regen. Med U. Toronto ON Tissue engineering— screening Suuronen, Erik University of Ottawa Heart Institute U. Ottawa ON Stem cells— mesenchymal and endothelial progenitor; Biomaterials— scaffolds Tabori, Uri Hospital for Sick Children U. Toronto ON Stem cells—cancer Tabrizian, Maryam McGill U. QC Biomaterials; Tissue engineering— scaffolds Tanentzapf, Guy U. British Columbia BC Stem cells— unspecified McMaster U. ON Stem cells—cancer U. Toronto ON Technology—Stem cells—cancer; High throughput technology Tang, Damu St. Joseph’s Hospital (Hamilton) Tanner, Scott Tannock, Ian Frederick Ontario Cancer Institute, University Health Network U. Toronto ON Stem cells—cancer Tator, Charles Toronto General Research Institute, University Health Network U. Toronto ON Stem cells—adult Tetzlaff, Wolfram U. British Columbia BC Stem cells— unspecified Thebaud, Bernard U. Alberta AB Stem cells—lung Tian, Ganghong (Hong) Associated with National Research Council of Canada, Institute for Biological Sciences U. Manitoba MB Stem cells—fat Till, Jim Ontario Cancer Institute, University Health Network U. Toronto ON Stem cells— hematopoietic U. Waterloo ON Biomaterials— scaffolds U. British Columbia BC Stem cells—bone marrow Tran, Simon McGill U. QC Stem cells—bone marrow Tredget, Edward Eric U. Alberta AB Stem cells—bone marrow U. Laval QC Stem cells—bone marrow Toyserkani, Ehsan Toze, Cynthia Tremblay, Jacques 88 universitY/ institution BC Cancer Agency Centre hospitalier de l’Université Laval appendiX 3A. RESEARCHERS IN ALPHABETICAL ORDER disease endoWed CHair url eMail Various CRC in Micro and Nano Engineering Systems amnl.mie.utoronto.ca%20/ [email protected] Cardiology No www.ottawaheart.ca/misc/erik-suuronen.htm [email protected] Cancer—brain No www.sickkids.ca/aboutsickkids/directory/people/t/ uri-tabori.html [email protected] Cardiovascular No /www.bmed.mcgill.ca/tabrizian/people_pages/ maryam.htm [email protected] Musculoskeletal No celldevelopment.ubc.ca/research/researchers/drguy-tanentzapf/ [email protected] Cancer—prostate No /www.hamiltonkidneyresearch.ca/page.aspx?menu= 39&app=173&cat1=433&tp=2&lk=no [email protected] Cancer No www.chem.utoronto.ca/ppl/faculty_profile. php?id=186 [email protected] Cancer No www.uhnresearch.ca/researchers/profile. php?lookup=5941 [email protected] Neurological—spinal cord injury No www.uhnresearch.ca/researchers/profile. php?lookup=5950 [email protected] Neurological—spinal cord injury No www.zoology.ubc.ca/person/~tetzlaff www.zoology.ubc.ca/person/~tetzlaff Respiratory CRC in Translational Lung and Vascular Development Biology www.physiology.ualberta.ca/home/People/ Academic/thebaud.cfm [email protected] Cardiology No www.nrc-cnrc.gc.ca/eng/people/tian_ ganghong_6253.html [email protected] Cancer No myprofile.cos.com/tillj16 [email protected] Musculoskeletal No www.mme.uwaterloo.ca/people/info.php?id=70 [email protected] Cancer— hematological No www.leukemiabmtprogram.org/general_information/ about_us/our_doctors/toze.html [email protected] Dental CRC in Craniofacial Stem Cells and Tissue Engineering www.mcgill.ca/dentistry/research/tran/ [email protected] Cutaneous No www.surgery.ualberta.ca/Home/Divisions/surgical_ research.cfm [email protected] Musculoskeletal— muscular dystrophy No www.vrr.ulaval.ca/bd/chercheur/fiche/228703.html [email protected] 3 89 3 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE RESEARCHERS 3a. Cont’d universitY/ institution provinCe Tremblay, Michel L. McGill U. QC Stem cells— hematopoietic Trigatti, Bernardo Louis McMaster U. ON Stem cells—bone marrow Tropepe, Vince U. Toronto ON Stem cells—neural researCHer researCH institution Tsai, Eve Sprott Centre for Stem Cell Research, Ottawa Health Research Institute U. Ottawa ON Stem cells— unspecified Tsilfidis, Catherine Sprott Centre for Stem Cell Research, Ottawa Health Research Institute U. Ottawa ON Stem cells—adult McGill U. QC Biomaterials— scaffolds Tufenkji, Nathalie Turksen, Kursad Sprott Centre for Stem Cell Research, Ottawa Health Research Institute U. Ottawa ON Stem cells—various— embryonic, epidermal Turner, Robin Michael Smith Laboratories U. British Columbia BC Technology—Stem cells—embryonic; Analysis, production Tyndale, Rachel U. Toronto ON Stem cells— pluripotent— embryonic, induced pluripotent Underhill, Michael U. British Columbia BC Stem cells—cord blood Unsworth, Larry U. Alberta AB Biomaterials— scaffolds U. Toronto ON Stem cells—neural (incl. retinal) Vanderluit, Jacqueline Memorial U. NL Stem cells—neural Verchere, Bruce U. British Columbia BC Stem cells—adult Veres, Teodor U. Laval QC Biomaterials; Tissue engineering—cells Vermette, Patrick U. Sherbrooke QC Tissue engineering— cell culture; Biomaterials— scaffolds Vincent, Michel U. Laval QC Stem cells—muscle progenitor U. Toronto ON Regeneration—heart van der Kooy, Derek von Harsdorf, Rudiger 90 tYpe of regen. Med McEwen Centre for Regenerative Medicine, Toronto General Research Institute, University Health Network McEwen Centre for Regenerative Medicine, Toronto General Research Institute, University Health Network appendiX 3A. RESEARCHERS IN ALPHABETICAL ORDER disease endoWed CHair Cardiology url eMail No www.mcgill.ca/biochemistry/department/faculty/ tremblay/ [email protected] Cardiovascular No www.science.mcmaster.ca/biochem/faculty/trigatti/ [email protected] Neurological development No www.utoronto.ca/tropepe-lab/people.html [email protected] Neurological—spinal cord injury No www.ohri.ca/profiles/tsai.asp [email protected] Eye Don and Joy Maclaren Chair for Vision Research (previously) www.ohri.ca/profiles/tsilfidis.asp [email protected] Musculoskeletal CRC in Biocolloids and Surfaces people.mcgill.ca/nathalie.tufenkji/ [email protected] Cutaneous No www.ohri.ca/profiles/turksen.asp [email protected] Various No www.msl.ubc.ca/faculty/turner [email protected] Various CRC in Pharmacogenetics www.pharmtox.utoronto.ca/faculty/directory/tyndale. htm [email protected] Musculoskeletal No www.cellphys.ubc.ca/faculty_pages/underhill.html [email protected] Various No www.cme.engineering.ualberta.ca/en/FacultyStaff/ FacultyAcademicStaff/Unsworth.aspx [email protected] Neurological—brain; Eye No medbio.utoronto.ca/faculty/vanderkooy.html [email protected] Neurological No www.med.mun.ca/Medicine/Faculty/Vanderluit,Jackie.aspx [email protected] Metabolic—diabetes No www.pathology.ubc.ca/NewPathology/Professor/ Bruce_Verchere.html [email protected] Cardiovascular No www.vrr.ulaval.ca/bd/chercheur/fiche/551399.html [email protected] Metabolic—diabetes No www.usherbrooke.ca/gchimiquebiotech/personnel/ professeurs/patrick-vermette/ [email protected] Various— cardiovascular, musculoskeletal No www.vrr.ulaval.ca/bd/chercheur/fiche/4934.html [email protected] Cardiology No www.uhnresearch.ca/researchers/profile. php?lookup=10949 [email protected] 3 91 3 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE RESEARCHERS 3a. Cont’d universitY/ institution provinCe U. Saskatchewan Sask Social science & humanities U. Toronto ON Stem cells— mesenchymal Waldman, Stephen Queens U. ON Tissue engineering— cell culture Walker, Gilbert Creighton U. Toronto ON Biomaterials researCHer researCH institution von Tigerstrom, Barbara Waddell, Thomas McEwen Centre for Regenerative Medicine, Toronto General Research Institute, University Health Network Wall, Donna Cancer Care Manitoba U. Manitoba MB Stem cells— hematological Wallace, Valerie Sprott Centre for Stem Cell Research, Ottawa Health Research Institute U. Ottawa ON Stem cells—retinal Walus, Konrad U. British Columbia BC Biomaterials— scaffolds Wang, Chen U. Toronto ON Stem cells— hematopoietic Wang, Lisheng U. Ottawa ON Stem cells—embryonic Ward, Christopher Andrew Queen’s U. ON Stem cells— mesenchymal Warnock, Garth Vancouver Coastal Health Research Institute U. British Columbia BC Stem cells— pancreatic (islet) Weisel, Richard Toronto General Research Institute, University Health Network U. Toronto ON Tissue engineering: Stem cells— transplantation Weiss, Samuel Associated with Hotchkiss Brain Institute U. Calgary AB Stem cells—neural Wells, Richard Alexander Sunnybrook Research Institute U. Toronto ON Stem cells— hematopoietic Wells, Sarah Dalhousie U. NS Tissue engineering— scaffolds Wertheimer, Michel Robert École polytechnique de Montréal QC Biomaterials U. Toronto ON Tissue engineering U. Ottawa ON Stem cells— mesenchymal Whyne, Cari Sunnybrook Research Institute Wiper-Bergeron, Nadine Louise 92 tYpe of regen. Med Wong, Peggy Hospital for Sick Children U. Toronto ON Stem cells—cancer Woodgett, James Samuel Lunenfeld Research Institute, Mount Sinai Hospital U. Toronto ON Stem cells—adult appendiX 3A. RESEARCHERS IN ALPHABETICAL ORDER disease endoWed CHair url eMail SSH: Law No www.usask.ca/law/about_us/bio.php?id=19 [email protected] Respiratory—lung transplant No www.uhnresearch.ca/researchers/profile. php?lookup=6315 [email protected] Musculoskeletal CRC in Engineering of Human Joints www.chemeng.queensu.ca/people/faculty/waldman/ [email protected] Cardiovascular CRC in Molecular Microscopy and Nanophotonic Devices www.chem.utoronto.ca/~gwalker/ [email protected] Cancer No www.cancercare.mb.ca/resource/File/Super_ Seven_Bios.pdf [email protected] Eye No www.ohri.ca/profiles/wallace.asp [email protected] Various— musculoskeletal, cutaneous No www.mina.ubc.ca/konradw [email protected] Hematological— anemia No icarus.med.utoronto.ca/patho/faculty. asp?FacultyID=233 [email protected] Various No www.med.uottawa.ca/associations/oisb/members/ member_lisheng_wang.htm [email protected] Cardiology No www.queensu.ca/cgi-bin/ph/whois.queensu. ca?Query=deptcode=D922_34 [email protected] Metabolic—diabetes No www.surgery.ubc.ca/faculty/gwarnock.html [email protected] Cardiology No www.uhn.ca/media/faq/experts/research/res_exp_ weisel.asp [email protected] Neurological—brain, olfactory No www.ucalgary.ca/gdrg/sweiss.html [email protected] Cancer—leukemia No sunnybrook.ca/research/team/member. asp?t=13&m=177&page=187 [email protected] Cardiovascular No bme.medicine.dal.ca/faculty/wells/ [email protected] Various No www.polymtl.ca/recherche/rc/en/professeurs/ details.php?NoProf=150 [email protected] Musculoskeletal No sunnybrook.ca/research/team/member. asp?t=13&m=178&page=172 [email protected] Musculoskeletal No www.med.uottawa.ca/research/wiper-bergeronlab/ [email protected] Cancer—leukemia No www.ontariodoctordirectory.ca/Toronto/DoctorPeggy-Pui-Chi-Wong-31836.html N/A Various, incl. cancer, metabolic—diabetes, neurological No www.lunenfeld.ca/researchers/woodgett [email protected] 3 93 3 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE RESEARCHERS 3a. Cont’d researCHer researCH institution Woodhouse, Kimberly provinCe tYpe of regen. Med Queen’s U. ON Tissue engineering— scaffolds, stem cells Wouters, Bradley Ontario Cancer Institute, University Health Network U. Toronto ON Stem cells—cancer Wrana, Jeffrey Samuel Lunenfeld Research Institute, Mount Sinai Hospital U. Toronto ON Technology—stem cells—high throughput analysis Wynder, Christopher McMaster U. ON Stem cells—embryonic Yahia, L’Hocine École polytechnique de Montreal QC Biomaterials Yang, Xiang-Jiao McGill U. QC Stem cells—various— unspecified Yip, Christopher The Donnelly Centre U. Toronto ON Stem cells— hematopoietic Yong, Von Wee Associated with Hotchkiss Brain Institute U. Calgary AB Stem cells— hematopoietic U. Toronto ON Stem cells—cancer U. Toronto ON Stem cells—various including embryonic, hematopoietic U. Laval QC Tissue engineering— scaffolds Zackenhaus, Eldad Zandstra, Peter McEwen Centre for Regenerative Medicine, University Health Network and Institute of Biomaterials and Biomedical Engineering, Donnelly Centre Zhang, Ze 94 universitY/ institution Ziltener, Hermann Johann Biomedical Research Centre U. British Columbia BC Tissue engineering— scaffolds Zúñiga-Pflücker, Juan-Carlos Sunnybrook Research Institute U. Toronto ON Stem cells—embryonic appendiX 3A. RESEARCHERS IN ALPHABETICAL ORDER disease endoWed CHair Cardiovascular url eMail No chemeng.queensu.ca/people/faculty/woodhouse/ index.php [email protected] Cancer No www.uhnres.utoronto.ca/researchers/profile. php?lookup=27665 [email protected] Cancer CRC in Systems Biology; Mary Janigan Research Chair in Molecular Cancer Therapeutics www.lunenfeld.ca/researchers/Wrana [email protected] Cancer CRC in Epigenetic Control of Stem Cells fhs.mcmaster.ca/main/canada_chairs/epigenetic_ control_of_stem_cells_chair.html [email protected] Musculoskeletal No www.polymtl.ca/recherche/rc/en/professeurs/ details.php?NoProf=243 [email protected] Aging No www.mcgill.ca/mog/research/yang/ [email protected] Various No biochemistry.utoronto.ca/yip/bch.html [email protected] Neurological—multiple sclerosis No www.hbi.ucalgary.ca/members/yong [email protected] Cancer No medbio.utoronto.ca/faculty/zacksenhaus.html [email protected] Various, incl. hematological CRC in Stem Cell Bioengineering stemcell.ibme.utoronto.ca/ [email protected] Various No www.crchuq.ulaval.ca/en/research/researchers/8491 www.vrr.ulaval.ca/bd/chercheur/fiche/283780.html [email protected] Various No www.brc.ubc.ca/drupal5/node/38 [email protected] Immunological— immunodeficiency CRC in Developmental Immunology www.sunnybrook.ca/research/team/member. asp?t=13&m=191&page=1100 [email protected] 3 95 3 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE RESEARCHERS 3b. Researchers According to Regenerative Medicine Focus universitY/ institution provinCe regen. Med desCription Acker, Jason U. Alberta AB Tissue engineering—cell storage Amsden, Brian Queens U. ON Tissue engineering—scaffolds researCHer researCH institution tissue engineering inCluding BioMaterials Antoniou, John Jewish General Hospital McGill U. QC Tissue engineering—scaffold; Stem cells— mesenchymal Auger, François A. LOEX U. Laval QC Tissue engineering—cell culture Barralet, Jake McGill U. QC Biomaterials Barrett, Christopher McGill U. QC Biomaterials U. Laval QC Tissue engineering—stem cells Berthod, François LOEX Brash, John McMaster U. ON Biomaterials Brunette, Donald Biomedical Research Centre U. British Columbia BC Tissue engineering—biomaterials, stem cells—mesenchymal Burt, Helen Mary Biomedical Research Centre U. British Columbia BC Tissue engineering—biomaterials, stem cells—mesenchymal Buschmann, Michael École polytechnique de Montréal QC Biomaterials Cao, Xudong U. Ottawa ON Biomaterials; Tissue engineering—stem cells Catelas, Isabelle U. Ottawa ON Tissue engineering McGill U. QC Tissue engineering—artificial blood cells Chen, Daniel (Xiongbiao) U. Saskatchewan Sask Tissue engineering—scaffolds Davies, John U. Toronto ON Tissue engineering—scaffolds; Stem cells—mesnchymal De Crescenzo, Gregory École polytechnique de Montréal QC Biomaterials Doillon, Charles U. Laval QC Tissue engineering—biomaterials El-Hakim, Assaad McGill U. QC Tissue engineering—biomaterials, cells U. Toronto ON Tissue engineering —cells, scaffold Chang, Thomas Ming Swi Farhat, Walid 96 Artificial Cells and Organs Research Centre Hospital for Sick Children appendiX 3B. RESEARCHERS ACCORDING TO REGENERATIVE MEDICINE FOCUS universitY/ institution provinCe regen. Med desCription Faucheux, Nathalie U. Sherbrooke QC Biomaterials—scaffolds Favis, Basil École polytechnique de Montréal QC Biomaterials—scaffolds Fernlund, Goran U. British Columbia BC Tissue engineering—biomaterials, stem cells—mesenchymal Filiaggi, Mark J. Dalhousie U. NS Biomaterials Ghanem, Amyl Dalhousie U. NS Biomaterials—tissue engineering researCHer researCH institution Giasson, Claude J. LOEX affiliation U. Montréal QC Tissue engineering Goulet, Francine LOEX U. Laval QC Tissue engineering—biomaterials, culture Griffith, May Sprott Centre for Stem Cell Research, Ottawa Health Research Institute U. Ottawa ON Biomaterials—scaffolds; Tissue engineering—stem cells Hamilton, Douglas U. Western Ontario ON Biomaterials; Tissue engineering Harvey, Edward McGill U. QC Biomaterials; Tissue engineering—cells Hoare, Todd McMaster U. ON Biomaterials Hoemann, Caroline École polytechnique de Montréal QC Tissue engineering—cells; Biomaterials Hunter, Christopher U. Calgary AB Tissue engineering—stem cells; Biomaterials Johnston, James U. Saskatchewan Sask Tissue engineering—scaffolds Jones, Elizabeth McGill U. QC Tissue engineering Jones, Kim McMaster U. ON Biomaterials Kamacheva, Eugenia U. Toronto ON Biomaterials Kandel, Rita Samuel Lunenfeld Research Institute, Mount Sinai Hospital U. Toronto ON Tissue engineering—biomaterials, stem cells Keeley, Fred Hospital for Sick Children U. Toronto ON Biomaterials U. British Columbia BC Tissue engineering—scaffolds U. Alberta AB Tissue engineering—stem cells, islet; Transplantation Ko, Frank Korbutt, Gregory Alberta Diabetes Institute 3 97 3 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE RESEARCHERS 3b. Cont’d universitY/ institution provinCe regen. Med desCription Dalhousie U. NS Biomaterials—scaffolds U. Laval QC Tissue engineering Langelier, Eve U. Sherbrooke QC Tissue engineering; Biomaterials Legge, Raymond U. Waterloo ON Tissue engineering—scaffolds U. Toronto ON Tissue engineering—cells U. Western Ontario ON Tissue engineering—scaffolds researCHer researCH institution Kreplak, Laurent Lacroix, Dan McGuigan, Alison LOEX Institute of Biomaterials and Biomedical Engineering Mequanint, Kibret Moulin, Véronique U. Laval QC Tissue engineering—stem cells Nanci, Antonio U. Montréal QC Tissue engineering—cells; Biomaterials Nazhat, Showan McGill U. QC Biomaterials—scaffolds; Tissue engineering Pilliar, Robert U. Toronto ON Biomaterials; Tissue engineering U. Laval QC Tissue engineering; Biomaterials Prakash, Satya McGill U. QC Biomaterials; Tissue engineering Quinn, Thomas McGill U. QC Tissue engineering Radisic, Milica U. Toronto ON Tissue engineering—scaffolds, cells; Stem cells—angiogenic progenitor Ramsay, Bruce Queens U. ON Tissue engineering—scaffolds Reinhardt, Dieter McGill U. QC Tissue engineering—biomaterials, cells Santerre, Paul U. Toronto ON Tissue engineering—biomaterials, cells U. Toronto ON Tissue engineering—biomaterials, cells McMaster U. ON Biomaterials U. Toronto ON Tissue engineering: biomaterials— scaffolds; Stem cells Sun, Yu U. Toronto ON Tissue engineering—screening Tabrizian, Maryam McGill U. QC Biomaterials; Tissue engineering—scaffolds Toyserkani, Ehsan U. Waterloo ON Biomaterials—scaffolds Tufenkji, Nathalie McGill U. QC Biomaterials—scaffolds Unsworth, Larry U. Alberta AB Biomaterials—scaffolds Veres, Teodor U. Laval QC Biomaterials; Tissue engineering—cells Vermette, Patrick U. Sherbrooke QC Tissue engineering—cell culture; Biomaterials—scaffolds Pouliot, Roxane Sefton, Michael LOEX LOEX The Donnelly Centre Sheardown, Heather Shoichet, Molly 98 McEwen Centre for Regenerative Medicine, Toronto General Research Institute, University Health Network appendiX 3B. RESEARCHERS ACCORDING TO REGENERATIVE MEDICINE FOCUS researCHer researCH institution universitY/ institution provinCe regen. Med desCription Waldman, Stephen Queens U. ON Tissue engineering—cell culture Walker, Gilbert Creighton U. Toronto ON Biomaterials Walus, Konrad U. British Columbia BC Biomaterials—scaffolds U. Toronto ON Tissue engineering: Stem cells— transplantation Wells, Sarah Dalhousie U. NS Tissue engineering—scaffolds Wertheimer, Michel Robert École polytechnique de Montréal QC Biomaterials U. Toronto ON Tissue engineering Woodhouse, Kimberly Queen’s U. ON Tissue engineering—scaffolds, stem cells Yahia, L’Hocine École polytechnique de Montréal QC Biomaterials Zhang, Ze U. Laval QC Tissue engineering—scaffolds Biomedical Research Centre U. British Columbia BC Tissue engineering—scaffolds Includes: Pharmaceutical Production Research Facility U. Calgary AB Bioprocessing—stem cells production/ culture Garnier, Alain U. Laval QC Bioprocessing—stem cells—culture Jervis, Eric U. Waterloo ON Bioprocessing—cell culture; Tissue engineering Jolicoeur, Mario École polytechnique de Montréal QC Bioprocessing U. Calgary AB Bioprocessing—stem cells, tissue culture U. Calgary AB Bioprocessing—stem cells—adult Weisel, Richard Whyne, Cari Ziltener, Hermann Johann Toronto General Research Institute, University Health Network Sunnybrook Research Institute 3 BioproCessing Behie, Leo Kallos, Michael Sen, Arindom Includes: Pharmaceutical Production Research Facility steM Cell Handling teCHnologies (e.g., HigH tHrougHput sorting, CrYopreservation) Elliott, Janet Anne Wade U. Alberta AB Technology—stem cells— cryopreservation Figeys, Daniel U. Ottawa ON Technology—stem cells—cell handling McGann, Locksley Earl U. Alberta AB Technology—stem cells— cryopreservation Park, Edward U. Victoria BC Technology—stem cells—cell sorting 99 3 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE RESEARCHERS 3b. Cont’d researCHer researCH institution universitY/ institution Michael Smith Laboratories provinCe regen. Med desCription U. British Columbia BC Technology—stem cells, incl. hematopoietic—high throughput analysis; Bioprocessing—cell culture Simmons, Craig U. Toronto ON Technology—high throughput screening; Stem cells—mesenchymal, cord blood; Tissue engineering Tanner, Scott U. Toronto ON Technology—stem cells—cancer; High throughput technology Piret, James Turner, Robin Michael Smith Laboratories U. British Columbia BC Technology—stem cells—embryonic; Analysis, production Wrana, Jeffrey Samuel Lunenfeld Research Institute, Mount Sinai Hospital U. Toronto ON Technology—stem cells—high throughput analysis Ottawa Hospital Research Institute U. Ottawa ON Regeneration—unspecified—tissue U. Toronto ON Regenerative medicine—unspecified U. Toronto ON Regeneration—unspecified—heart Baylis, Françoise Dalhousie U. NS Social science & humanities Bubela, Tania U. Alberta AB Social science & humanities Caulfield, Tim U. Alberta AB Social science & humanities Chandler, Jennifer U. Ottawa ON Social science & humanities U. Toronto ON Social science & humanities Einsiedel, Edna U. Calgary AB Social science & humanities Glass, Kathleen McGill U. QC Social science & humanities Illes, Judy U. British Columbia BC Social science & humanities Ingram, Liz U. Alberta AB Social science & humanities Knoppers, Bartha McGill U. QC Social science & humanities Leibing, Annette U. Montréal QC Social science & humanities Lemmens, Trudo U. Toronto ON Social science & humanities Leroux, Therese U. Montréal QC Social science & humanities McDonald, Michael U. British Columbia BC Social science & humanities Menon, Devidas U. Alberta AB Social science & humanities regeneration unspeCified Akimenko, Marie-Andrée Downey, Gregory von Harsdorf, Rudiger McEwen Centre for Regenerative Medicine, Toronto General Research Institute, University Health Network soCial sCienCes & HuManities Daar, Abdallah 100 McLaughlin-Rotman Centre for Global Health, University Health Network appendiX 3B. RESEARCHERS ACCORDING TO REGENERATIVE MEDICINE FOCUS researCHer researCH institution von Tigerstrom, Barbara universitY/ institution provinCe regen. Med desCription U. Saskatchewan Sask Social science & humanities 3 steM Cells—pluripotent eMBrYoniC Bader, Gary Institute of Biomaterials and Biomedical Engineering U. Toronto ON Stem cells—embryonic Doble, Bradley Stem Cell and Cancer Research Institute McMaster U. ON Stem cells—embryonic Draper, Jonathan Stem Cell and Cancer Research Institute McMaster U. ON Stem cells—embryonic McGill U. QC Stem cells—embryonic Dufort, Daniel Dumont, Dan Sunnybrook Research Institute U. Toronto ON Stem cells—embryonic Emili, Andrew The Donnelly Centre— Banting and Best Department of Medical Research U. Toronto ON Stem cells—embryonic Gregory-Evan, Kevin Vancouver Coastal Health Research Institute U. British Columbia BC Stem cells—embryonic Gutkowska, Jolanta Centre de recherche du Centre hospitalier de l’Université de Montréal U. Montréal QC Stem cells—embryonic Helgason, Cheryl BC Cancer Agency U. British Columbia BC Stem cells—embryonic Hicks, Geoffrey Cancer Care Manitoba—Institute of Cell Biology U. Manitoba MB Stem cells—embryonic Hoodless, Pamela Terry Fox Laboratory, BC Cancer Agency U. British Columbia BC Stem cells—embryonic Huang, Sui U. Calgary AB Stem cells—embryonic Hughes, Timothy The Donnelly Centre— Banting and Best Department of Medical Research U. Toronto ON Stem cells—embryonic Husain, Mansoor McEwen Centre for Regenerative Medicine, Toronto General Research Institute, University Health Network U. Toronto ON Stem cells—embryonic Julius, Michael Sunnybrook Research Institute U. Toronto ON Stem cells—embryonic U. Ottawa ON Stem cells—embryonic Kaern, Mads 101 3 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE RESEARCHERS 3b. Cont’d researCH institution universitY/ institution provinCe regen. Med desCription Keller, Gordon McEwen Centre for Regenerative Medicine and Ontario Cancer Institute, University Health Network U. Toronto ON Stem cells—embryonic Kelly, Kevin Francis Stem Cell and Cancer Research Institute McMaster U. ON Stem cells—embryonic Kothary, Rashmi K. Ottawa Hospital Research Institute U. Ottawa ON Stem cells—embryonic Lajoie, Gilles U. Western Ontario ON Stem cells—embryonic Lefebvre, Louis U. British Columbia BC Stem cells—embryonic Lynn, Francis U. British Columbia BC Stem cells—embryonic U. British Columbia BC Stem cells—embryonic U. Calgary AB Stem cells—embryonic U. Ottawa ON Stem cells—embryonic U. Alberta AB Stem cells—embryonic U. Toronto ON Stem cells—embryonic Opas, Michal J. U. Toronto ON Stem cells—embryonic Pang, Stephen Queen’s U. ON Stem cells—embryonic Pilon, Nicolas U. Québec à Montréal QC Stem cells—embryonic researCHer Marra, Marco BC Cancer Agency, Genome Sciences Centre Matyas, John Robert McBurney, Michael Ottawa Hospital Research Institute Michalak, Marek S. Morris, Quaid The Donnelly Centre, Banting and Best Department of Medical Research Post, Martin Hospital for Sick Children U. Toronto ON Stem cells—embryonic Puri, Mira Sunnybrook Research Institute U. Toronto ON Stem cells—embryonic Rossant, Janet Hospital for Sick Children U. Toronto ON Stem cells—embryonic U. Calgary AB Stem cells—embryonic U. Toronto ON Stem cells—embryonic Skerjanc, Ilona Sylvia U. Ottawa ON Stem cells—embryonic Smith, Lawrence C. U. Montréal QC Stem cells—embryonic McGill U. QC Stem cells—embryonic U. Ottawa ON Stem cells—embryonic Santamaria, Pere Schuh, Andre Stifani, Stefano Wang, Lisheng 102 Ontario Cancer Institute, University Health Network Montreal Neurological Institute appendiX 3B. RESEARCHERS ACCORDING TO REGENERATIVE MEDICINE FOCUS universitY/ institution provinCe regen. Med desCription McMaster U. ON Stem cells—embryonic U. Toronto ON Stem cells—embryonic U. Western Ontario ON Stem cells—pluripotent—induced pluripotent U. Toronto ON Stem cells—pluripotent—induced pluripotent U. Toronto ON Stem cells—pluripotent—embryonic, induced pluripotent Grant, Denis U. Toronto ON Stem cells—pluripotent—embryonic, induced pluripotent Rafuse, Victor Dalhousie U. NS Stem cells—pluripotent—embryonic, induced pluripotent; neural Rancourt, Derrick U. Calgary AB Stem cells—pluripotent—embryonic, induced pluripotent Rastegar, Mojgan U. Manitoba MB Stem cells—pluripotent—induced pluripotent, embryonic Tyndale, Rachel U. Toronto ON Stem cells—pluripotent—embryonic, induced pluripotent McGill U. QC Stem cells—adult unspecified researCHer researCH institution Wynder, Christopher Zúñiga-Pflücker, Juan-Carlos Sunnybrook Research Institute 3 induCed pluripotent Betts, Dean Moffat, Jason The Donnelly Centre induCed pluripotent and eMBrYoniC Ellis, James Hospital for Sick Children steM Cells—tissue speCifiC steM Cells—adult unspeCified Antel, Jack Bani, Mahmud Associated with National Research Council of Canada, Institute for Biological Sciences U. Ottawa ON Stem cells—adult unspecified Brodt, Pnina The Research Institute of the McGill University Health Centre McGill U. QC Stem cells—adult—stromal Carrier, Patrick LOEX U. Laval QC Stem cells—adult—epithelial (from cornea) Courtman, David Sprott Centre for Stem Cell Research, Ottawa Hospital Research Institute U. Ottawa ON Stem cells—adult—endothelial progenitor Germain, Lucie LOEX U. Laval QC Stem cells—adult—epithelial McMaster U. ON Stem cells—adult, cancer Hassell, John Hill, David Lawson Health Research Institute, London Health Sciences Centre U. Western Ontario ON Stem cells—adult unspecified Horb, Markoe Institut de recherches cliniques de Montréal U. Montréal QC Stem cells—adult—endodermal progenitors 103 3 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE RESEARCHERS 3b. Cont’d researCH institution universitY/ institution provinCe regen. Med desCription Jirik, Frank Southern Alberta Cancer Research Institute U. Calgary AB Stem cells—adult unspecified Metz, Luanne Associated with Hotchkiss Brain Institute U. Calgary AB Stem cells—adult—endogenous progenitor Prato, Frank Lawson Health Research Institute, London Health Sciences Centre U. Western Ontario ON Stem cells—adult—endothelial progenitor Stewart, Duncan Sprott Centre for Stem Cell Research, Ottawa Health Research Institute U. Ottawa ON Stem cells—adult unspecified Tator, Charles Toronto General Research Institute, University Health Network U. Toronto ON Stem cells—adult unspecified Tsilfidis, Catherine Sprott Centre for Stem Cell Research, Ottawa Health Research Institute U. Ottawa ON Stem cells—adult unspecified U. British Columbia BC Stem cells—adult unspecified U. Toronto ON Stem cells—adult unspecified U. Laval QC Stem cells—amniotic U. Western Ontario ON Stem cells—bone marrow (mesenchymal, hematopoietic) Jackson, Michael U. Manitoba MB Stem cells—bone marrow Keating, Armand U. Toronto ON Stem cells—bone marrow—mesenchymal, hematopoietic Krieger, Charles Simon Fraser U. BC Stem cells—bone marrow U. Western Ontario ON Stem cells—bone marrow U. British Columbia BC Stem cells—bone marrow researCHer Verchere, Bruce Woodgett, James Samuel Lunenfeld Research Institute, Mount Sinai Hospital steM Cells—aMniotiC Puymirat, Jack steM Cells—Bone MarroW Hess, David Lewis, James Franklin John P. Robarts Research Institute Lawson Health Research Institute, London Health Sciences Centre Putnins, Edward 104 Qayumi, Karim Vancouver Coastal Health Research Institute U. British Columbia BC Stem cells—bone marrow Rivest, Serge Centre hospitalier de l’Université Laval U. Laval QC Stem cells—bone marrow appendiX 3B. RESEARCHERS ACCORDING TO REGENERATIVE MEDICINE FOCUS researCHer researCH institution universitY/ institution Toze, Cynthia BC Cancer Agency provinCe regen. Med desCription U. British Columbia BC Stem cells—bone marrow Tran, Simon McGill U. QC Stem cells—bone marrow Tredget, Edward Eric U. Alberta AB Stem cells—bone marrow U. Laval QC Stem cells—bone marrow McMaster U. ON Stem cells—bone marrow U. Western Ontario ON Stem cells—cancer McMaster U. ON Stem cells—cancer U. British Columbia BC Stem cells—cancer Dankort, David McGill U. QC Stem cells—cancer DeCoteau, John U. Saskatchewan Sask Stem cells—cancer Geyer, Ronald U. Saskatchewan Sask Stem cells—cancer Ghanekar, Anand U. Toronto ON Stem cells—cancer Giacomantonio, Carman A. Dalhousie U. NS Stem cells—cancer Tremblay, Jacques Centre hospitalier de l’Université Laval Trigatti, Bernardo Louis 3 steM Cells—CanCer Allan, Alison London Regional Cancer Program, London Health Sciences Centre Bramson, Jonathan Brinkman, Ryan Terry Fox Laboratory, BC Cancer Agency Hedley, David William Ontario Cancer Institute, University Health Network U. Toronto ON Stem cells—cancer Hill, Richard Ontario Cancer Institute, University Health Network U. Toronto ON Stem cells—cancer U. Manitoba MB Stem cells—cancer Hombach-Klonisch, Sabine Kamnasaran, Deepak U. Laval QC Stem cells—cancer Kaplan, David Hospital for Sick Children U. Toronto ON Stem cells—cancer Klonisch, Thomas CancerCare Manitoba U. Manitoba MB Stem cells—cancer Dalhousie U. NS Stem cells—cancer Lee, Patrick W.K. Neel, Benjamin Ontario Cancer Institute, University Health Network U. Toronto ON Stem cells—cancer O’Brien, Catherine Adell Ontario Cancer Institute, University Health Network U. Toronto ON Stem cells—cancer U. Alberta AB Stem cells—cancer McGill U. QC Stem cells—cancer Pilarski, Linda Rak, Janusz The Research Institute of the McGill University Health Centre 105 3 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE RESEARCHERS 3b. Cont’d researCHer Raouf, Afshin researCH institution universitY/ institution provinCe regen. Med desCription Cancer Care Manitoba—Institute of Cell Biology U. Manitoba MB Stem cells—cancer U. Toronto ON Stem cells—cancer Reilly, Raymond Matthew Roy, Denis-Claude Centre de recherche de l’Hôpital MaisonneuveRosemont U. Montréal QC Stem cells—cancer Schimmer, Aaron Ontario Cancer Institute, University Health Network U. Toronto ON Stem cells—cancer Singh, Sheila Stem Cell and Cancer Research Institute McMaster U. ON Stem cells—cancer Tabori, Uri Hospital for Sick Children U. Toronto ON Stem cells—cancer Tang, Damu St. Joseph’s Hospital (Hamilton) McMaster U. ON Stem cells—cancer Tannock, Ian Frederick Ontario Cancer Institute, University Health Network U. Toronto ON Stem cells—cancer Wong, Peggy Hospital for Sick Children U. Toronto ON Stem cells—cancer Wouters, Bradley Ontario Cancer Institute, University Health Network U. Toronto ON Stem cells—cancer U. Toronto ON Stem cells—cancer U. Ottawa ON Stem cells—cardiac Dalhousie U. NS Stem cells—cardiac progenitor U. Ottawa ON Stem cells—cardiac Chen, Jie U. Alberta AB Stem cells—cord blood Couban, Stephen Dalhousie U. NS Stem cells—cord blood Duval, Michel U. Montréal QC Stem cells—cord blood Underhill, Michael U. British Columbia BC Stem cells—cord blood U. Calgary AB Stem cells—dermal Zackenhaus, Eldad steM Cells—CardiaC Megeney, Lynn Sprott Centre for Stem Cell Research, Ottawa Health Research Institute Pasumarthi, Kishore Babu S. Stewart, Alexandre University of Ottawa Heart Institute steM Cells—Cord Blood steM Cells—derMal Biernaskie, Jeffrey A. 106 Associated with Hotchkiss Brain Institute appendiX 3B. RESEARCHERS ACCORDING TO REGENERATIVE MEDICINE FOCUS researCHer researCH institution Li, Julang Midha, Rajiv universitY/ institution provinCe 3 regen. Med desCription U. Guelph ON Stem cells—dermal Associated with Hotchkiss Brain Institute U. Calgary AB Stem cells—dermal Associated with National Research Council of Canada, Institute for Biological Sciences U. Manitoba MB Stem cells—fat Queen’s U. ON Stem cells—fat; Tissue engineering— scaffolds steM Cells—fat Arora, Rakesh C. Flynn, Lauren Fradette, Julie LOEX U. Laval QC Stem cells—fat; Tissue engineering Tian, Ganghong (Hong) Associated with National Research Council of Canada, Institute for Biological Sciences U. Manitoba MB Stem cells—fat Institut de recherches cliniques de Montréal U. Montréal QC Stem cells—fetal Dalhousie U. NS Stem cells—fetal Bjerknes, Matthew J. U. Toronto ON Stem cells—gastrointestinal Kieffer, Tim U. British Columbia BC Stem cells—gastrointestinal U. Calgary AB Stem cells—germline—testis McGill U. QC Stem cells—germline—sperm McGill U. QC Stem cells—germline steM Cells—fetal Drouin, Jacques Mendez, Ivar steM Cells—gastrointestinal steM Cells—gerMline Dobrinski, Ina Nagano, Makoto The Research Institute of the McGill University Health Centre Robaire, Bernard steM Cells—HeMatopoietiC Allan, David Sprott Centre for Stem Cell Research, Ottawa Health Research Institute U. Ottawa ON Stem cells—hematopoietic Anderson, Michele Sunnybrook Research Institute U. Toronto ON Stem cells—hematopoietic Atkins, Harry Sprott Centre for Stem Cell Research, Ottawa Health Research Institute U. Ottawa ON Stem cells—hematopoietic 107 3 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE RESEARCHERS 3b. Cont’d researCHer Audet, Julie researCH institution universitY/ institution provinCe regen. Med desCription Institute of Biomaterials and Biomedical Engineering U. Toronto ON Stem cells—hematopoietic U. Laval QC Stem cells—hematopoietic Barabé, Frédéric Barber, Dwayne Ontario Cancer Institute, University Health Network U. Toronto ON Stem cells—hematopoietic Beausejour, Christian Hôpital Sainte-Justine (Montréal) U. Montréal QC Stem cells—hematopoietic Ben-David, Yaacov Sunnybrook Research Institute U. Toronto ON Stem cells—hematopoietic U. Montréal QC Stem cells—hematopoietic Bijl, Janetta Brand, Marjorie Sprott Centre for Stem Cell Research, Ottawa Health Research Institute U. Ottawa ON Stem cells—hematopoietic Carreau, Madeleine Centre hospitalier de l’Université Laval U. Laval QC Stem cells—hematopoietic Casper, Robert Samuel Lunenfeld Research Institute, Mount Sinai Hospital U. Toronto ON Stem cells—hematopoietic Crump, Michael A. Ontario Cancer Institute, University Health Network U. Toronto ON Stem cells—hematopoietic Denburg, Judah Aryeh McMaster U. ON Stem cells—hematopoietic Doyle, John U. Toronto ON Stem cells—hematopoietic U. British Columbia BC Stem cells—hematopoietic Eaves, Allen Terry Fox Laboratory, BC Cancer Agency Ellis, Anne 108 Queen’s U. ON Stem cells—hematopoietic (cord blood) Gassas, Adam Hospital for Sick Children U. Toronto ON Stem cells—hematopoietic Guidos, Cynthia Hospital for Sick Children U. Toronto ON Stem cells—hematopoietic Heveker, Nikolaus Hôpital Sainte-Justine U. Montréal QC Stem cells—hematopoietic Hoang, Trang Institute for Research in Immunology and Cancer U. Montréal QC Stem cells—hematopoietic Hogge, Donna Terry Fox Laboratory, BC Cancer Agency U. British Columbia BC Stem cells—hematopoietic Hope, Kristin Jill Stem Cell and Cancer Research Institute McMaster U. ON Stem cells—hematopoietic Humphries, Keith Terry Fox Laboratory, BC Cancer Agency U. British Columbia BC Stem cells—hematopoietic appendiX 3B. RESEARCHERS ACCORDING TO REGENERATIVE MEDICINE FOCUS researCH institution universitY/ institution provinCe regen. Med desCription Iscove, Norman McEwen Centre for Regenerative Medicine, and Ontario Cancer Institute, University Health Network U. Toronto ON Stem cells—hematopoietic Jiang, Xiaoyan Terry Fox Laboratory, BC Cancer Agency U. British Columbia BC Stem cells—hematopoietic U. Toronto ON Stem cells—hematopoietic researCHer Joshi, Sadhna Karsan, Aly BC Cancer Agency U. British Columbia BC Stem cells—hematopoietic Krystal, Gerald Terry Fox Laboratory, BC Cancer Agency U. British Columbia BC Stem cells—hematopoietic Lessard, Julie Institute for Research in Immunology and Cancer U. Montréal QC Stem cells—hematopoietic Levesque, Eric Centre hospitalier de l’Université Laval U. Laval QC Stem cells—hematopoietic Li, Ren-Ke McEwen Centre for Regenerative Medicine, Toronto General Research Institute, University Health Network U. Toronto ON Stem cells—hematopoietic McNagny, Kelly Biomedical Research Centre U. British Columbia BC Stem cells—hematopoietic Minden, Mark David Ontario Cancer Institute, University Health Network U. Toronto ON Stem cells—hematopoietic Mollica, Luigina Centre de recherche de l’Hôpital MaisonneuveRosemont U. Montréal QC Stem cells—hematopoietic Moroy, Tarik Institut de recherches cliniques de Montréal U. Montréal QC Stem cells—hematopoietic Munoz Risueno, Ruth Stem Cell and Cancer Research Institute McMaster U. ON Stem cells—hematopoietic Nevill, Thomas Vancouver Coastal Health Research Institute U. British Columbia BC Stem cells—hematopoietic Podor, Thomas iCapture U. British Columbia BC Stem cells—hematopoietic (bone marrow) Robert, François Institut de recherches cliniques de Montréal U. Montréal QC Stem cells—hematopoietic Rossi, Fabio Biomedical Research Centre U. British Columbia BC Stem cells—hematopoietic Rottapel, Robert Ontario Cancer Institute, University Health Network U. Toronto ON Stem cells—hematopoietic 3 109 3 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE RESEARCHERS 3b. Cont’d researCH institution universitY/ institution provinCe regen. Med desCription Roy, Jean Centre de recherche de l’Hôpital MaisonneuveRosemont U. Montréal QC Stem cells—hematopoietic Schrader, John W. Biomedical Research Centre U. British Columbia BC Stem cells—hematopoietic Schultz, Kirk Child & Family Research Institute U. British Columbia BC Stem cells—hematopoietic Smith, Clayton Terry Fox Laboratoy, BC Cancer Agency U. British Columbia BC Stem cells—hematopoietic Song, Kevin Vancouver Coastal Health Research Institute U. British Columbia BC Stem cells—hematopoietic Till, Jim Ontario Cancer Institute, University Health Network U. Toronto ON Stem cells—hematopoietic McGill U. QC Stem cells—hematopoietic U. Manitoba MB Stem cells—hematopoietic U. Toronto ON Stem cells—hematopoietic researCHer Tremblay, Michel L. Wall, Donna Cancer Care Manitoba Wang, Chen Wells, Richard Alexander Sunnybrook Research Institute U. Toronto ON Stem cells—hematopoietic Yip, Christopher The Donnelly Centre U. Toronto ON Stem cells—hematopoietic Yong, Von Wee Associated with Hotchkiss Brain Institute U. Calgary AB Stem cells—hematopoietic U. Alberta AB Stem cells—lung steM Cells—lung Thebaud, Bernard steM Cells—MaMMarY Dedhar, Shoukat BC Cancer Agency U. British Columbia BC Stem cells—mammary Egan, Sean Hospital for Sick Children U. Toronto ON Stem cells—mammary epithelial Hospital for Sick Children U. Toronto ON Stem cells—mesenchymal U. Toronto ON Stem cells—mesenchymal U. Toronto ON Stem cells—mesenchymal McGill U. QC Stem cells—mesenchymal steM Cells—MesenCHYMal Alman, Benjamin Aubin, Jane Dick, Alexander Sunnybrook Research Institute Eliopoulos, Nicoletta Ferguson, Peter Charles Mount Sinai Hospital Frei, Hanspeter Hebert, Marie-Josee 110 Centre de recherche du Centre hospitalier de l’Université de Montréal U. Toronto ON Stem cells—mesenchymal stromal Carleton U. ON Stem cells—mesenchymal U. Montréal QC Stem cells—mesenchymal appendiX 3B. RESEARCHERS ACCORDING TO REGENERATIVE MEDICINE FOCUS researCH institution universitY/ institution provinCe regen. Med desCription Ly, Hung Montreal Heart Institute U. Montréal QC Stem cells—mesenchymal Mak, Tak Ontario Cancer Institute, University Health Network U. Toronto ON Stem cells—mesenchymal McElwee, Kevin Vancouver Coastal Health Research Institute U. British Columbia BC Stem cells—mesenchymal Mwale, Fackson Jewish General Hospital, Lady Davis Institute McGill U. QC Stem cells—mesenchymal Ohashi, Pamela Sumiko Ontario Cancer Institute, University Health Network U. Toronto ON Stem cells—mesenchymal Pelletier, Marc New Brunswick Heart Centre New Brunswick Heart Centre NB Stem cells—mesenchymal Shaw, Patricia Ann Ontario Cancer Institute, University Health Network U. Toronto ON Stem cells—mesenchymal Suuronen, Erik University of Ottawa Heart Institute U. Ottawa ON Stem cells—mesenchymal and endothelial progenitor; Biomaterials—scaffolds Waddell, Thomas McEwen Centre for Regenerative Medicine, Toronto General Research Institute, University Health Network U. Toronto ON Stem cells—mesenchymal Ward, Christopher Andrew Queen’s U. ON Stem cells—mesenchymal Wiper-Bergeron, Nadine Louise U. Ottawa ON Stem cells—mesenchymal U. Ottawa ON Stem cells—muscle progenitors Grenier, Guillaume U. Sherbrooke QC Stem cells—muscle progenitors Hawke, Thomas McMaster U. ON Stem cells—muscle progenitor Merrifield, Peter U. Western Ontario ON Stem cells—muscle Parise, Gianni McMaster U. ON Stem cells—muscle Savard, Pierre U. Laval QC Stem cells—muscle Vincent, Michel U. Laval QC Stem cells—muscle progenitor U. Toronto ON Stem cells—neural U. Ottawa ON Stem cells—neural U. Montréal QC Stem cells—neural researCHer 3 steM Cells—MusCle Dilworth, Jeffrey Sprott Centre for Stem Cell Research, Ottawa Health Research Institute steM Cells—neural Aviv, Tzvi Hospital for Sick Children Bennett, Steffany Calderone, Angelo Montreal Heart Institute 111 3 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE RESEARCHERS 3b. Cont’d researCH institution universitY/ institution provinCe regen. Med desCription Cayouette, Michel Institut de recherches cliniques de Montréal U. Montréal QC Stem cells—neural Cregan, Sean John P. Robarts Research Institute U. Western Ontario ON Stem cells—neural Dirks, Peter Hospital for Sick Children U. Toronto ON Stem cells—neural Fehlings, Michael McEwen Centre for Regenerative Medicine and McLaughlin Center for Molecular Medicine, Toronto Western Research Institute, University Health Network U. Toronto ON Stem cells—neural U. Montréal QC Stem cells—neural researCHer Fernandes, Karl Hazell, Alan Stewart Centre de recherche du Centre hospitalier de l’Université de Montréal U. Montréal QC Stem cells—neural Huang, Annie Hospital for Sick Children U. Toronto ON Stem cells—neural U. Manitoba MB Stem cells—neural U. British Columbia BC Stem cells—neural U. Toronto ON Stem cells—neural Karimi-Abdolrezaee, Soheila Kim, Seung Vancouver Coastal Health Research Institute Laposa, Rebecca Lecanu, Laurent The Research Institute of the McGill University Health Centre McGill U. QC Stem cells—neural Levin, Leonard Centre de recherche de l’Hôpital MaisonneuveRosemont U. Montréal QC Stem cells—neural Morshead, Cindi U. Toronto ON Stem cells—neural Roskams, Jane U. British Columbia BC Stem cells—neural Tropepe, Vince U. Toronto ON Stem cells—neural U. Toronto ON Stem cells—neural (incl. retinal) Memorial U. NL Stem cells—neural van der Kooy, Derek Vanderluit, Jacqueline 112 McEwen Centre for Regenerative Medicine, Toronto General Research Institute, University Health Network appendiX 3B. RESEARCHERS ACCORDING TO REGENERATIVE MEDICINE FOCUS researCH institution universitY/ institution provinCe regen. Med desCription Associated with Hotchkiss Brain Institute U. Calgary AB Stem cells—neural McGill U. QC Stem cells—ovarian epithelial Anderson, Colin C. U. Alberta AB Stem cells—pancreatic (islet) Johnson, James U. British Columbia BC Stem cells—pancreatic (islet) researCHer Weiss, Samuel 3 steM Cells—ovarian epitHelial Farookhi, Riaz steM Cells—panCreatiC Rajotte, Raymond V. U. Alberta AB Stem cells—pancreatic Rosenberg, Lawrence The Research Institute of the McGill University Health Centre McGill U. QC Stem cells—pancreatic Warnock, Garth Vancouver Coastal Health Research Institute U. British Columbia BC Stem cells—pancreatic (islet) U. Victoria BC Stem cells—retinal U. Ottawa ON Stem cells—retinal U. Western Ontario ON Stem cells—vascular U. Québec à Montréal QC Stem cells—unspecified steM Cells—retinal Chow, Bob Wallace, Valerie Sprott Centre for Stem Cell Research, Ottawa Health Research Institute steM Cells—vasCular Khan, Zia steM Cells—unspeCified Annabi, Borhane Cheng, Hai-Ling Margaret Sunnybrook Research Institute U. Toronto ON Stem cells—unspecified Dekaban, Gregory John P. Robarts Research Institute U. Western Ontario ON Stem cells—unspecified Dennis, James W. Samuel Lunenfeld Research Institute, Mount Sinai Hospital U. Toronto ON Stem cells—unspecified U. Calgary AB Stem cells—unspecified U. Calgary AB Stem cells—unspecified U. Montréal QC Stem cells—unspecified U. Toronto ON Stem cells—unspecified Duff, Henry Joseph Dyck, Richard Henry Associated with Hotchkiss Brain Institute Emery, Gregory Gramolini, Anthony Orlando The Donnelly Centre, Banting and Best Department of Medical Research 113 3 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE RESEARCHERS 3b. Cont’d researCH institution universitY/ institution provinCe regen. Med desCription The Donnelly Centre, Banting and Best Department of Medical Research U. Toronto ON Stem cells—unspecified U. Calgary AB Stem cells—unspecified U. Toronto ON Stem cells—unspecified York U. ON Stem cells—unspecified U. Toronto ON Stem cells—unspecified Kwon, Brian U. British Columbia BC Stem cells—unspecified Labbé, Jean-Claude U. Montréal QC Stem cells—unspecified Lagace, Diane U. Ottawa ON Stem cells—unspecified researCHer Greenblatt, Jack Hansen, David Kislinger, Thomas Ontario Cancer Institute, UHN Krylov, Sergey N. Kuruvilla, John Ontario Cancer Institute, University Health Network Larouche, Danielle LOEX U. Laval QC Stem cells—unspecified Leavitt, Blair Centre for Molecular Medicine & Therapeutics U. British Columbia BC Stem cells—unspecified Queen’s U. ON Stem cells—unspecified U. Western Ontario ON Stem cells—unspecified Nemer, Mona U. Ottawa ON Stem cells—unspecified Postovit, Lynne-Marie U. Western Ontario ON Stem cells—unspecified Lilicrap, David Meakin, Susan John P. Robarts Research Institute Reudelhuber, Timothy Luther Institut de recherches cliniques de Montréal U. Montréal QC Stem cells—unspecified Schuurmans, Carol Associated with Hotchkiss Brain Institute U. Calgary AB Stem cells—unspecified Slack, Ruth Ottawa Hospital Research Institute U. Ottawa ON Stem cells—unspecified Stanisz, Greg Sunnybrook Research Institute U. Toronto ON Stem cells—unspecified Tanentzapf, Guy U. British Columbia BC Stem cells—unspecified Tetzlaff, Wolfram U. British Columbia BC Stem cells—unspecified Sprott Centre for Stem Cell Research, Ottawa Health Research Institute U. Ottawa ON Stem cells—unspecified BC Cancer Agency U. British Columbia BC Stem cells—various—hematopoietic, induced pluripotent Tsai, Eve steM Cells—various Aparicio, Samuel 114 appendiX 3B. RESEARCHERS ACCORDING TO REGENERATIVE MEDICINE FOCUS researCHer Bhatia, Mickie researCH institution universitY/ institution provinCe regen. Med desCription Stem Cell and Cancer Research Institute McMaster U. ON Stem cells—various—pluripotent, embryonic, hematopoietic U. Calgary AB Stem cells—various—embryonic, trophoblast, placental, germline Cross, James Charles Dick, John McEwen Centre for Regenerative Medicine and Ontario Cancer Institute, University Health Network U. Toronto ON Stem cells—various, incl. hematopoietic Eaves, Connie Terry Fox Laboratory, BC Cancer Agency U. British Columbia BC Stem cells—various (embryonic, hematopoietic, breast epithelial) U. Western Ontario ON Stem cells—various Golding, Michael C. Hough, Margaret Sunnybrook Research Institute U. Toronto ON Stem cells—various—embryonic, hematopoietic Hui, Chi-chung Hospital for Sick Children U. Toronto ON Stem cells—various Jolicoeur, Paul Institut de recherches cliniques de Montréal U. Montréal QC Stem cells—various—cancer/mammary Lansdorp, Peter Terry Fox Laboratory, BC Cancer Agency U. British Columbia BC Stem cells—various—hematopoietic, induced pluripotent, embryonic Levy, Gary Toronto General Research Institute, University Health Network U. Toronto ON Stem cells—various Marshall, Aaron U. Manitoba MB Stem cells—various Massie, Bernard Associated with National Research Council— Biotechnology Research Institute U. Montréal QC Stem cells—various—adult McInnes, Roderick Jewish General Hospital, Lady Davis Institute McGill U. QC Stem cells—various—embryonic, adult McKerlie, Colin Samuel Lunenfeld Research Institute, Mount Sinai Hospital U. Toronto ON Stem cells—various Miller, Freda McEwen Centre for Regenerative Medicine, Toronto General Research Institute, University Health Network U. Toronto ON Stem cells—various—dermal, neural 3 115 3 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE RESEARCHERS 3b. Cont’d researCH institution universitY/ institution provinCe regen. Med desCription Nagy, Andras Samuel Lunenfeld Research Institute, Mount Sinai Hospital and McEwen Centre for Regenerative Medicine, University Health Network U. Toronto ON Stem cells—various—pluripotent— induced pluripotent, embryonic; Somatic Paige, Christopher Ontario Cancer Institute, University Health Network U. Toronto ON Stem cells—various—embryonic, cancer U. Québec à Montréal QC Stem cells—various—embryonic, adult researCHer Paquin, Joanne Perkins, Theodore Sprott Center for Stem Cell Research, Ottawa Health Research Institute U. Ottawa ON Stem cells—various Rogers, Ian Samuel Lunenfeld Research Institute, Mount Sinai Hospital U. Toronto ON Stem cells—various—cord blood, induced pluripotent, bone marrow Rudnicki, Michael Sprott Centre for Stem Cell Research, Ottawa Hospital Research Institute U. Ottawa ON Stem cells—various—embryonic, muscle, other adult Ruel, Marc University of Ottawa Heart Institute U. Ottawa ON Stem cells—various—mesenchymal and endothelial progenitor; Tissue engineering Sabourin, Luc Ottawa Hospital Research Institute U. Ottawa ON Stem cells—various—embryonic, adult Sauvageau, Guy Institute for Research in Immunology and Cancer U. Montréal QC Stem cells—various—hematopoietic, embryonic Seguin, Cheryle U. Western Ontario ON Stem cells—various—pluripotent, neural Stanford, William U. Toronto ON Stem cells—various—pluripotent— induced pluripotent, embryonic; Mesenchymal U. Ottawa ON Stem cells—various—embryonic, epidermal McGill U. QC Stem cells—various U. Toronto ON Stem cells—various including embryonic, hematopoietic Turksen, Kursad Sprott Centre for Stem Cell Research, Ottawa Health Research Institute Yang, Xiang-Jiao Zandstra, Peter 116 McEwen Centre for Regenerative Medicine, University Health Network and Institute of Biomaterials and Biomedical Engineering, Donnelly Centre appendiX 3C. RESEARCHERS ACCORDING TO DISEASE FOCUS 3 3c. Researchers According to Disease Focus researCHer researCH institution universitY/ institution provinCe disease desCription McGill U. QC Aging aging Yang, Xiang-Jiao CanCer Allan, Alison London Regional Cancer Program, London Health Sciences Centre U. Western Ontario ON Cancer—breast Anderson, Michele Sunnybrook Research Institute U. Toronto ON Cancer—leukemia, lymphoma U. Québec à Montréal QC Cancer BC Cancer Agency U. British Columbia BC Cancer—breast U. Laval QC Cancer—leukemia Beausejour, Christian Hôpital Sainte-Justine (Montréal) U. Montréal QC Cancer Ben-David, Yaacov Sunnybrook Research Institute U. Toronto ON Cancer—leukemia U. Montréal QC Cancer—leukemia Annabi, Borhane Aparicio, Samuel Barabé, Frédéric Bijl, Janetta McMaster U. ON Cancer Brinkman, Ryan Bramson, Jonathan Terry Fox Laboratory, BC Cancer Agency U. British Columbia BC Cancer Brodt, Pnina The Research Institute of the McGill University Health Centre McGill U. QC Cancer Dalhousie U. NS Cancer— hematological U. Toronto ON Cancer—lymphoma Couban, Stephen Crump, Michael A. Ontario Cancer Institute, University Health Network Dankort, David McGill U. QC Cancer DeCoteau, John U. Saskatchewan Sask Cancer Dedhar, Shoukat BC Cancer Agency U. British Columbia BC Cancer Dennis, James W. Samuel Lunenfeld Research Institute, Mount Sinai Hospital U. Toronto ON Cancer, other Dick, John McEwen Centre for Regenerative Medicine and Ontario Cancer Institute, University Health Network U. Toronto ON Cancer, incl. leukemia Dirks, Peter Hospital for Sick Children U. Toronto ON Cancer—brain Doble, Bradley Stem Cell and Cancer Research Institute McMaster U. ON Cancer U. Toronto ON Cancer Doyle, John Eaves, Allen Terry Fox Laboratory, BC Cancer Agency U. British Columbia BC Cancer—leukemia Eaves, Connie Terry Fox Laboratory, BC Cancer Agency U. British Columbia BC Cancer 117 3 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE RESEARCHERS 3c. Cont’d researCHer researCH institution universitY/ institution provinCe disease desCription Egan, Sean Hospital for Sick Children U. Toronto ON Cancer—breast U. Montréal QC Cancer Emery, Gregory Emili, Andrew The Donnelly Centre—Banting and Best Department of Medical Research U. Toronto ON Cancer Gassas, Adam Hospital for Sick Children U. Toronto ON Cancer—leukemia U. Saskatchewan Sask Cancer Geyer, Ronald Ghanekar, Anand U. Toronto ON Cancer—liver Giacomantonio, Carman A. Dalhousie U. NS Cancer Grant, Denis U. Toronto ON Cancer U. Toronto ON Cancer—leukemia McMaster U. ON Cancer Guidos, Cynthia Hospital for Sick Children Hassell, John Hedley, David William Ontario Cancer Institute, University Health Network U. Toronto ON Cancer—cervical Hicks, Geoffrey Cancer Care Manitoba— Institute of Cell Biology U. Manitoba MB Cancer Hill, Richard Ontario Cancer Institute, University Health Network U. Toronto ON Cancer—cervical Hoang, Trang Institute for Research in Immunology and Cancer U. Montréal QC Cancer—leukemia Hogge, Donna Terry Fox Laboratory, BC Cancer Agency U. British Columbia BC Cancer—leukemia U. Manitoba MB Cancer Hombach-Klonisch, Sabine Hope, Kristin Jill Stem Cell and Cancer Research Institute McMaster U. ON Cancer—leukemia Huang, Annie Hospital for Sick Children U. Toronto ON Cancer—brain Iscove, Norman McEwen Centre for Regenerative Medicine, and Ontario Cancer Institute, University Health Network U. Toronto ON Cancer—leukemia Jiang, Xiaoyan Terry Fox Laboratory, BC Cancer Agency U. British Columbia BC Cancer—leukemia Jirik, Frank Southern Alberta Cancer Research Institute U. Calgary AB Cancer Jolicoeur, Paul Institut de recherches cliniques de Montréal U. Montréal QC Cancer U. Laval QC Cancer—brain Kamnasaran, Deepak Kaplan, David Hospital for Sick Children U. Toronto ON Cancer Karsan, Aly BC Cancer Agency U. British Columbia BC Cancer—leukemia U. Toronto ON Cancer— hematological U. Manitoba MB Cancer Keating, Armand Klonisch, Thomas 118 CancerCare Manitoba appendiX 3C. RESEARCHERS ACCORDING TO DISEASE FOCUS universitY/ institution provinCe disease desCription Terry Fox Laboratory, BC Cancer Agency U. British Columbia BC Cancer Ontario Cancer Institute, University Health Network U. Toronto ON Cancer— hematological U. Montréal QC Cancer U. British Columbia BC Cancer, other Dalhousie U. NS Cancer researCHer researCH institution Krystal, Gerald Kuruvilla, John Labbé, Jean-Claude Lansdorp, Peter Terry Fox Laboratory, BC Cancer Agency Lee, Patrick W.K. Lessard, Julie Institute for Research in Immunology and Cancer U. Montréal QC Cancer— hematological Levesque, Eric Centre hospitalier de l’Université Laval U. Laval QC Cancer Mak, Tak Ontario Cancer Institute, University Health Network U. Toronto ON Cancer Minden, Mark David Ontario Cancer Institute, University Health Network U. Toronto ON Cancer—leukemia Moroy, Tarik Institut de recherches cliniques de Montréal U. Montréal QC Cancer— hematological Munoz Risueno, Ruth Stem Cell and Cancer Research Institute McMaster U. ON Cancer—leukemia Neel, Benjamin Ontario Cancer Institute, University Health Network U. Toronto ON Cancer—ovarian Nevill, Thomas Vancouver Coastal Health Research Institute U. British Columbia BC Cancer O’Brien, Catherine Adell Ontario Cancer Institute, University Health Network U. Toronto ON Cancer—colorectal Ohasi, Pamela Sumiko Ontario Cancer Institute, University Health Network U. Toronto ON Cancer Paige, Christopher Ontario Cancer Institute, University Health Network U. Toronto ON Cancer Pilarski, Linda U. Alberta AB Cancer—multiple myeloma Postovit, Lynne-Marie U. Western Ontario ON Cancer Prakash, Satya McGill U. QC Cancer Rak, Janusz The Research Institute of the McGill University Health Centre McGill U. QC Cancer—brain Raouf, Afshin Cancer Care Manitoba— Institute of Cell Biology U. Manitoba MB Cancer—breast U. Toronto ON Cancer—leukemia Reilly, Raymond Matthew Roy, Denis-Claude Centre de recherche de l’Hôpital MaisonneuveRosemont U. Montréal QC Cancer—leukemia Roy, Jean Centre de recherche de l’Hôpital MaisonneuveRosemont U. Montréal QC Cancer—leukemia 3 119 3 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE RESEARCHERS 3c. Cont’d universitY/ institution provinCe Institute for Research in Immunology and Cancer U. Montréal QC Cancer— hematological; Other Schimmer, Aaron Ontario Cancer Institute, University Health Network U. Toronto ON Cancer—leukemia Schultz, Kirk Child & Family Research Institute U. British Columbia BC Cancer—leukemia Shaw, Patricia Ann Ontario Cancer Institute, University Health Network U. Toronto ON Cancer Singh, Sheila Stem Cell and Cancer Research Institute McMaster U. ON Cancer—brain Smith, Clayton Terry Fox Laboratoy, BC Cancer Agency U. British Columbia BC Cancer— hematological Song, Kevin Vancouver Coastal Health Research Institute U. British Columbia BC Cancer—lymphoma Tabori, Uri Hospital for Sick Children U. Toronto ON Cancer—brain Tang, Damu St. Joseph’s Hospital (Hamilton) McMaster U. ON Cancer—prostate U. Toronto ON Cancer researCHer researCH institution Sauvageau, Guy Tanner, Scott disease desCription Tannock, Ian Frederick Ontario Cancer Institute, University Health Network U. Toronto ON Cancer Till, Jim Ontario Cancer Institute, University Health Network U. Toronto ON Cancer Toze, Cynthia BC Cancer Agency U. British Columbia BC Cancer— hematological Wall, Donna Cancer Care Manitoba U. Manitoba MB Cancer Wells, Richard Alexander Sunnybrook Research Institute U. Toronto ON Cancer—leukemia Wong, Peggy Hospital for Sick Children U. Toronto ON Cancer—leukemia Wouters, Bradley Ontario Cancer Institute, University Health Network U. Toronto ON Cancer Wrana, Jeffrey Samuel Lunenfeld Research Institute, Mount Sinai Hospital U. Toronto ON Cancer Wynder, Christopher McMaster U. ON Cancer Zackenhaus, Eldad U. Toronto ON Cancer Sprott Centre for Stem Cell Research, Ottawa Hospital Research Institute U. Ottawa ON Cardiopulmonary Allan, David Sprott Centre for Stem Cell Research, Ottawa Health Research Institute U. Ottawa ON Cardiovascular Arora, Rakesh C Associated with National Research Council of Canada, Institute for Biological Sciences U. Manitoba MB Cardiology CardiopulMonarY Courtman, David CardiovasCular 120 appendiX 3C. RESEARCHERS ACCORDING TO DISEASE FOCUS researCHer researCH institution universitY/ institution provinCe disease desCription Calderone, Angelo Montreal Heart Institute U. Montréal QC Cardiology Dick, Alexander Sunnybrook Research Institute U. Toronto ON Cardiology U. Calgary AB Cardiology Duff, Henry Joseph Gramolini, Anthony Orlando The Donnelly Centre, Banting and Best Department of Medical Research U. Toronto ON Cardiovascular Gutkowska, Jolanta Centre de recherche du Centre hospitalier de l’Université de Montréal U. Montréal QC Cardiology Husain, Mansoor McEwen Centre for Regenerative Medicine, Toronto General Research Institute, University Health Network U. Toronto ON Cardiovascular Jackson, Michael U. Manitoba MB Cardiology Jones, Elizabeth McGill U. QC Cardiovascular Keeley, Fred Hospital for Sick Children U. Toronto ON Cardiovascular Kislinger, Thomas Ontario Cancer Institute, UHN U. Toronto ON Cardiovascular Li, Ren-Ke McEwen Centre for Regenerative Medicine, Toronto General Research Institute, University Health Network U. Toronto ON Cardiovascular, cardiology Ly, Hung Montreal Heart Institute U. Montréal QC Cardiology Megeney, Lynn Sprott Centre for Stem Cell Research, Ottawa Health Research Institute U. Ottawa ON Cardiovascular Michalak, Marek S. U. Alberta AB Cardiovascular Nemer, Mona U. Ottawa ON Cardiology Pang, Stephen Queen’s U. ON Cardiology Pasumarthi, Kishore Babu S. Dalhousie U. NS Cardiology Pelletier, Marc New Brunswick Heart Centre New Brunswick Heart Centre NB Cardiology Podor, Thomas iCapture U. British Columbia BC Cardiology Prato, Frank Lawson Health Research Institute, London Health Sciences Centre U. Western Ontario ON Cardiology Qayumi, Karim Vancouver Coastal Health Research Institute U. British Columbia BC Cardiology U. Toronto ON Cardiology Radisic, Milica 3 Reudelhuber, Timothy Luther Institut de recherches cliniques de Montréal U. Montréal QC Cardiovascular Ruel, Marc University of Ottawa Heart Institute U. Ottawa ON Cardiology 121 3 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE RESEARCHERS 3c. Cont’d researCHer researCH institution Santerre, Paul universitY/ institution provinCe disease desCription U. Toronto ON Cardiovascular Stewart, Alexandre University of Ottawa Heart Institute U. Ottawa ON Cardiology Stewart, Duncan Sprott Centre for Stem Cell Research, Ottawa Health Research Institute U. Ottawa ON Cardiovascular Suuronen, Erik University of Ottawa Heart Institute U. Ottawa ON Cardiology McGill U. QC Cardiovascular U. Manitoba MB Cardiology Tremblay, Michel L. McGill U. QC Cardiology Trigatti, Bernardo Louis McMaster U. ON Cardiovascular Veres, Teodor U. Laval QC Cardiovascular U. Toronto ON Cardiology Walker, Gilbert Creighton U. Toronto ON Cardiovascular Ward, Christopher Andrew Queen’s U. ON Cardiology U. Toronto ON Cardiology Wells, Sarah Dalhousie U. NS Cardiovascular Woodhouse, Kimberly Queen’s U. ON Cardiovascular U. British Columbia BC Cutaneous U. Alberta AB Cutaneous U. Ottawa ON Cutaneous Hamilton, Douglas U. Western Ontario ON Dental Tran, Simon McGill U. QC Dental Tran, Simon McGill U. QC Dental U. Western Ontario ON Embryogenesis U. British Columbia BC Embryogenesis Tabrizian, Maryam Tian, Ganghong (Hong) von Harsdorf, Rudiger Weisel, Richard Associated with National Research Council of Canada, Institute for Biological Sciences McEwen Centre for Regenerative Medicine, Toronto General Research Institute, University Health Network Toronto General Research Institute, University Health Network Cutaneous McElwee, Kevin Vancouver Coastal Health Research Institute Tredget, Edward Eric Turksen, Kursad Sprott Centre for Stem Cell Research, Ottawa Health Research Institute dental eMBrYogenesis Golding, Michael C. Hoodless, Pamela 122 Terry Fox Laboratory, BC Cancer Agency appendiX 3C. RESEARCHERS ACCORDING TO DISEASE FOCUS researCHer researCH institution universitY/ institution provinCe disease desCription Puri, Mira Sunnybrook Research Institute U. Toronto ON Embryogenesis Rossant, Janet Hospital for Sick Children U. Toronto ON Embryogenesis U. Montréal QC Embryogenesis U. Toronto ON Gastrointestinal U. Toronto ON Genetic U. British Columbia BC Genetic Smith, Lawrence C. 3 gastrointestinal Bjerknes, Matthew J. genetiC Hough, Margaret Sunnybrook Research Institute Lefebvre, Louis HeMatologiCal Barber, Dwayne Ontario Cancer Institute, University Health Network U. Toronto ON Hematological— anemia, cancer Brand, Marjorie Sprott Centre for Stem Cell Research, Ottawa Health Research Institute U. Ottawa ON Hematological—ßthalassemia and sickle cell anemia Carreau, Madeleine Centre hospitalier de l’Université Laval U. Laval QC Hematological— anemia U. Calgary AB Hematological U. British Columbia BC Hematological— anemia, cancer Queen’s U. ON Hematological— hemophilia Huang, Sui Humphries, Keith Terry Fox Laboratory, BC Cancer Agency Lilicrap, David Robert, François Institut de recherches cliniques de Montréal U. Montréal QC Hematological Schuh, Andre Ontario Cancer Institute, University Health Network U. Toronto ON Hematological— hemophilia U. Toronto ON Hematological— anemia Denburg, Judah Aryeh McMaster U. ON Immunological— allergy, asthma Ellis, Anne Queen’s U. ON Immunological— allergy Wang, Chen iMMunologiCal Helgason, Cheryl BC Cancer Agency U. British Columbia BC Immunological— autoimmune Lewis, James Franklin Lawson Health Research Institute, London Health Sciences Centre U. Western Ontario ON Immunological— inflammation Schrader, John W. Biomedical Research Centre U. British Columbia BC Immunological— immunodeficiency Zúñiga-Pflücker, Juan-Carlos Sunnybrook Research Institute U. Toronto ON Immunological— immunodeficiency U. Toronto ON Infection—HIV infeCtion—Hiv Joshi, Sadhna 123 3 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE RESEARCHERS 3c. Cont’d researCHer researCH institution universitY/ institution provinCe disease desCription U. Alberta AB Metabolic—diabetes MetaBoliC—diaBetes Anderson, Colin C. Hill, David Lawson Health Research Institute, London Health Sciences Centre U. Western Ontario ON Metabolic—diabetes Horb, Markoe Institut de recherches cliniques de Montréal U. Montréal QC Metabolic—diabetes Johnson, James U. British Columbia BC Metabolic—diabetes Kieffer, Tim U. British Columbia BC Metabolic—diabetes U. Alberta AB Metabolic—diabetes; other Korbutt, Gregory Alberta Diabetes Institute Lynn, Francis U. British Columbia BC Metabolic—diabetes Rajotte, Raymond V. U. Alberta AB Metabolic—diabetes McGill U. QC Metabolic—diabetes Verchere, Bruce U. British Columbia BC Metabolic—diabetes Vermette, Patrick U. Sherbrooke QC Metabolic—diabetes Vancouver Coastal Health Research Institute U. British Columbia BC Metabolic—diabetes Akimenko, Marie-Andrée Ottawa Hospital Research Institute U. Ottawa ON Musculoskeletal Alman, Benjamin Hospital for Sick Children U. Toronto ON Musculoskeletal Antoniou, John Jewish General Hospital McGill U. QC Musculoskeletal Rosenberg, Lawrence Warnock, Garth The Research Institute of the McGill University Health Centre MusCulosKeletal Aubin, Jane U. Toronto ON Musculoskeletal Barralet, Jake McGill U. QC Musculoskeletal— bone formation Brunette, Donald Biomedical Research Centre U. British Columbia BC Musculoskeletal Burt, Helen Mary Biomedical Research Centre U. British Columbia BC Musculoskeletal Buschmann, Michael École polytechnique de Montréal QC Musculoskeletal— cartilage cell delivery Catelas, Isabelle U. Ottawa ON Musculoskeletal— bone loss Davies, John U. Toronto ON Musculoskeletal— bone U. Ottawa ON Musculoskeletal: Duchenne U. Sherbrooke QC Musculoskeletal— bone and cartilage regeneration U. Toronto ON Musculoskeletal Dilworth, Jeffrey Sprott Centre for Stem Cell Research, Ottawa Health Research Institute Faucheux, Nathalie Ferguson, Peter Charles 124 Mount Sinai Hospital appendiX 3C. RESEARCHERS ACCORDING TO DISEASE FOCUS researCHer researCH institution universitY/ institution provinCe disease desCription Fernlund, Goran U. British Columbia BC Musculoskeletal Filiaggi, Mark J. Dalhousie U. NS Musculoskeletal— bone U. Laval QC Musculoskeletal Carleton U. ON Musculoskeletal— bone U. Laval QC Musculoskeletal Grenier, Guillaume U. Sherbrooke QC Musculoskeletal— muscle Harvey, Edward McGill U. QC Musculoskeletal— bone Hawke, Thomas McMaster U. ON Musculoskeletal— muscle Hoemann, Caroline École polytechnique de Montréal QC Musculoskeletal Fradette, Julie LOEX Frei, Hanspeter Goulet, Francine LOEX Hunter, Christopher U. Calgary AB Musculoskeletal—disc Johnston, James U. Saskatchewan Sask Musculoskeletal U. Toronto ON Musculoskeletal U. Sherbrooke QC Musculoskeletal Kandel, Rita Samuel Lunenfeld Research Institute, Mount Sinai Hospital Langelier, Eve Matyas, John Robert U. Calgary AB Musculoskeletal Merrifield, Peter U. Western Ontario ON Musculoskeletal McGill U. QC Musculoskeletal—disc U. Montréal QC Musculoskeletal Mwale, Fackson Jewish General Hospital, Lady Davis Institute Nanci, Antonio Nazhat, Showan McGill U. QC Musculoskeletal Paquin, Joanne U. Québec à Montréal QC Musculoskeletal Parise, Gianni McMaster U. ON Musculoskeletal Pilliar, Robert U. Toronto ON Musculoskeletal— bone; Dental Pouliot, Roxane U. Laval QC Musculoskeletal Putnins, Edward U. British Columbia BC Musculoskeletal Puymirat, Jack U. Laval QC Mysculoskeletal myotonic dystrophy Quinn, Thomas McGill U. QC Musculoskeletal— cartilage, ligaments Rancourt, Derrick U. Calgary AB Musculoskeletal Reinhardt, Dieter McGill U. QC Musculoskeletal Tanentzapf, Guy U. British Columbia BC Musculoskeletal Toyserkani, Ehsan U. Waterloo ON Musculoskeletal U. Laval QC Musculoskeletal— muscular dystrophy Tremblay, Jacques LOEX Centre hospitalier de l’Université Laval 3 125 3 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE RESEARCHERS 3c. Cont’d universitY/ institution provinCe disease desCription Tufenkji, Nathalie McGill U. QC Musculoskeletal Underhill, Michael U. British Columbia BC Musculoskeletal Waldman, Stephen Queens U. ON Musculoskeletal U. Toronto ON Musculoskeletal Wiper-Bergeron, Nadine Louise U. Ottawa ON Musculoskeletal Yahia, L’Hocine École polytechnique de Montréal QC Musculoskeletal McGill U. QC Neurological—multiple sclerosis researCHer Whyne, Cari researCH institution Sunnybrook Research Institute neurologiCal Antel, Jack Aviv, Tzvi Hospital for Sick Children U. Toronto ON Neurological Bani, Mahmud Associated with National Research Council of Canada, Institute for Biological Sciences U. Ottawa ON Neurological—brain injury U. Ottawa ON Neurological, incl. Alzheimer’s U. Calgary AB Neurological—injury, wound healing U. Ottawa ON Neurological—spinal cord, eye Bennett, Steffany Biernaskie, Jeffrey A. Associated with Hotchkiss Brain Institute Cao, Xudong Carrier, Patrick LOEX U. Laval QC Eye Cayouette, Michel Institut de recherches cliniques de Montréal U. Montréal QC Neurological, including eye U. Saskatchewan Sask Neurological— peripheral U. Toronto ON Neurological—stroke U. Victoria BC Eye Chen, Daniel (Xiongbiao) Cheng, Hai-Ling Margaret Sunnybrook Research Institute Chow, Bob Cregan, Sean John P. Robarts Research Institute U. Western Ontario ON Neurological Dekaban, Gregory John P. Robarts Research Institute U. Western Ontario ON Neurological—spinal cord injury Drouin, Jacques Institut de recherches cliniques de Montréal U. Montréal QC Neurological— Parkinson’s Dyck, Richard Henry Associated with Hotchkiss Brain Institute U. Calgary AB Neurological—brain Fehlings, Michael McEwen Centre for Regenerative Medicine and McLaughlin Centre for Molecular Medicine, Toronto Western Research Institute, University Health Network U. Toronto ON Neurological—spinal cord injury U. Montréal QC Neurological— neurodegenerative diseases, incl. Alzheimer’s Fernandes, Karl 126 appendiX 3C. RESEARCHERS ACCORDING TO DISEASE FOCUS researCHer researCH institution universitY/ institution provinCe disease desCription Giasson, Claude J. LOEX affiliation U. Montréal QC Eye Gregory-Evan, Kevin Vancouver Coastal Health Research Institute U. British Columbia BC Eye Griffith, May Sprott Centre for Stem Cell Research, Ottawa Health Research Institute U. Ottawa ON Eye Hazell, Alan Stewart Centre de recherche du Centre hospitalier de l’Université de Montréal U. Montréal QC Neurological—brain injury Hui, Chi-chung Hospital for Sick Children U. Toronto ON Neurological U. Manitoba MB Neurological—spinal cord injury U. British Columbia BC Neurological Krieger, Charles Simon Fraser U. BC Neurological Kwon, Brian U. British Columbia BC Neurological—spinal cord injury Lagace, Diane U. Ottawa ON Neurological Karimi-Abdolrezaee, Soheila Kim, Seung Vancouver Coastal Health Research Institute Laposa, Rebecca U. Toronto ON Neurological Leavitt, Blair Centre for Molecular Medicine & Therapeutics U. British Columbia BC Neurological Lecanu, Laurent The Research Institute of the McGill University Health Centre McGill U. QC Neurological Levin, Leonard Centre de recherche de l’Hôpital MaisonneuveRosemont U. Montréal QC Eye Meakin, Susan John P. Robarts Research Institute U. Western Ontario ON Neurological Dalhousie U. NS Neurological Mendez, Ivar 3 Metz, Luanne Associated with Hotchkiss Brain Institute U. Calgary AB Neurological—multiple sclerosis Midha, Rajiv Associated with Hotchkiss Brain Institute U. Calgary AB Neurological Miller, Freda McEwen Centre for Regenerative Medicine, Toronto General Research Institute, University Health Network U. Toronto ON Neurological, incl. spinal cord injury Morshead, Cindi U. Toronto ON Neurological, other Pilon, Nicolas U. Québec à Montréal QC Neurological Rafuse, Victor Dalhousie U. NS Neurological, including Parkinson’s, ALS Rastegar, Mojgan U. Manitoba MB Neurological, cancerbrain 127 3 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE RESEARCHERS 3c. Cont’d researCHer researCH institution Rivest, Serge Centre hospitalier de l’Université Laval Roskams, Jane universitY/ institution provinCe disease desCription U. Laval QC Neurological U. British Columbia BC Neurological— olfactory Schuurmans, Carol Associated with Hotchkiss Brain Institute U. Calgary AB Neurological—stroke, spinal cord injury, eye Slack, Ruth Ottawa Hospital Research Institute U. Ottawa ON Neurological Stanisz, Greg Sunnybrook Research Institute U. Toronto ON Neurological Stifani, Stefano Montreal Neurological Institute McGill U. QC Neurological—ALS Tator, Charles Toronto General Research Institute, University Health Network U. Toronto ON Neurological—spinal cord injury Tetzlaff, Wolfram U. British Columbia BC Neurological—spinal cord injury Tropepe, Vince U. Toronto ON Neurological development Tsai, Eve Sprott Centre for Stem Cell Research, Ottawa Health Research Institute U. Ottawa ON Neurological—spinal cord injury Tsilfidis, Catherine Sprott Centre for Stem Cell Research, Ottawa Health Research Institute U. Ottawa ON Eye van der Kooy, Derek McEwen Centre for Regenerative Medicine, Toronto General Research Institute, University Health Network U. Toronto ON Neurological—brain; Eye Memorial U. NL Neurological Vanderluit, Jacqueline Wallace, Valerie Sprott Centre for Stem Cell Research, Ottawa Health Research Institute U. Ottawa ON Eye Weiss, Samuel Associated with Hotchkiss Brain Institute U. Calgary AB Neurological—brain, olfactory Yong, Von Wee Associated with Hotchkiss Brain Institute U. Calgary AB Neurological—multiple sclerosis Jewish General Hospital, Lady Davis Institute for Medical Research McGill U. QC Renal Samuel Lunenfeld Research Institute, Mount Sinai Hospital U. Toronto ON Reproduction—female fertility renal Eliopoulos, Nicoletta reproduCtion Casper, Robert 128 appendiX 3C. RESEARCHERS ACCORDING TO DISEASE FOCUS researCHer researCH institution universitY/ institution provinCe disease desCription Cross, James Charles U. Calgary AB Reproduction—female Dobrinski, Ina U. Calgary AB Reproduction—male Dufort, Daniel McGill U. QC Reproduction— implantation Farookhi, Riaz McGill U. QC Reproduction—ovary Li, Julang U. Guelph ON Reproduction—female; Other McGill U. QC Reproduction—male McGill U. QC Reproduction—male; Other U. Toronto ON Respiratory U. Toronto ON Respiratory U. Alberta AB Respiratory U. Toronto ON Respiratory—lung transplant Baylis, Françoise Dalhousie U. NS SSH: Ethics Bubela, Tania U. Alberta AB SSH: Socioeconomic benefits Caulfield, Tim U. Alberta AB SSH: Ethics and law Chandler, Jennifer U. Ottawa ON SSH: Law, policy U. Toronto ON SSH: Ethics and law Einsiedel, Edna U. Calgary AB SSH: Social science Glass, Kathleen McGill U. QC SSH: Ethics, legal Illes, Judy U. British Columbia BC SSH: Ethics Nagano, Makoto The Research Institute of the McGill University Health Centre Robaire, Bernard 3 respiratorY Downey, Gregory Post, Martin Hospital for Sick Children Thebaud, Bernard Waddell, Thomas McEwen Centre for Regenerative Medicine, Toronto General Research Institute, University Health Network soCial sCienCes & HuManities Daar, Abdallah McLaughlin-Rotman Centre for Global Health, University Health Network Ingram, Liz U. Alberta AB SSH: Social Knoppers, Bartha McGill U. QC SSH: Ethics, law, policy Leibing, Annette U. Montréal QC SSH: Social Lemmens, Trudo U. Toronto ON SSH: Law Leroux, Therese U. Montréal QC SSH: Policy McDonald, Michael U. British Columbia BC SSH: Ethic Menon, Devidas U. Alberta AB SSH: Policy von Tigerstrom, Barbara U. Saskatchewan Sask SSH: Law 129 3 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE RESEARCHERS 3c. Cont’d universitY/ institution provinCe disease desCription McGill U. QC Urological U. Toronto ON Urological Acker, Jason U. Alberta AB Various Amsden, Brian Queens U. ON Various researCHer researCH institution urologiCal El-Hakim, Assaad Farhat, Walid Hospital for Sick Children various Atkins, Harry Sprott Centre for Stem Cell Research, Ottawa Health Research Institute U. Ottawa ON Various, incl. cancer— hematopoietic, neurological—MS Audet, Julie Institute of Biomaterials and Biomedical Engineering U. Toronto ON Various Auger, François A. LOEX U. Laval QC Various, incl. cardiovascular, transplantation, injury Bader, Gary Institute of Biomaterials and Biomedical Engineering U. Toronto ON Various McGill U. QC Various Barrett, Christopher Behie, Leo Includes: Pharmaceutical Production Research Facility U. Calgary AB Various—neurological, metabolic—diabetes Berthod, François LOEX U. Laval QC Various, incl. neurological, urological, cutaneous U. Western Ontario ON Various Stem Cell and Cancer Research Institute McMaster U. ON Various, incl. respiratory—lung disease McMaster U. ON Various McGill U. QC Various, incl. cardiovascular Betts, Dean Bhatia, Mickie Brash, John Chang, Thomas Ming Swi Chen, Jie U. Alberta AB Various De Crescenzo, Gregory École polytechnique de Montréal QC Various— musculoskeletal, cardiovascular Doillon, Charles U. Laval QC Various— cardiovascular, cancer Draper, Jonathan Stem Cell and Cancer Research Institute McMaster U. ON Various Dumont, Dan Sunnybrook Research Institute U. Toronto ON Various— cardiovascular, cancer Duval, Michel U. Montréal QC Various Elliott, Janet Anne Wade U. Alberta AB Various U. Toronto ON Various, incl. neurological, incl. Rett’s; Hematological— anemia Ellis, James 130 Artificial Cells and Organs Research Centre Hospital for Sick Children appendiX 3C. RESEARCHERS ACCORDING TO DISEASE FOCUS researCHer researCH institution universitY/ institution provinCe disease desCription Favis, Basil École polytechnique de Montréal QC Various Figeys, Daniel U. Ottawa ON Various Flynn, Lauren Queen’s U. ON Various Garnier, Alain U. Laval QC Various LOEX U. Laval QC Various, incl. cutaneous, cardiovascular, eye Dalhousie U. NS Various The Donnelly Centre, Banting and Best Department of Medical Research U. Toronto ON Various U. Calgary AB Various Germain, Lucie Ghanem, Amyl Greenblatt, Jack Hansen, David Hebert, Marie-Josee Centre de recherche du Centre hospitalier de l’Université de Montréal U. Montréal QC Various—renal, cardiovascular Hess, David John P. Robarts Research Institute U. Western Ontario ON Various— cardiovascular; Metabolic—diabetes Heveker, Nikolaus Hôpital Sainte-Justine U. Montréal QC Various McMaster U. ON Various U. Toronto ON Various Hoare, Todd Hughes, Timothy The Donnelly Centre—Banting and Best Department of Medical Research Jervis, Eric U. Waterloo ON Various Jolicoeur, Mario École polytechnique de Montréal QC Various Jones, Kim McMaster U. ON Various, incl. immunological U. Toronto ON Various, incl. immunological, cancer, infection U. Ottawa ON Various U. Calgary AB Various U. Toronto ON Various Julius, Michael Sunnybrook Research Institute Kaern, Mads Kallos, Michael Includes: Pharmaceutical Production Research Facility Kamacheva, Eugenia Keller, Gordon McEwen Centre for Regenerative Medicine and Ontario Cancer Institute, University Health Network U. Toronto ON Various, incl. hematological, cardiovascular Kelly, Kevin Francis Stem Cell and Cancer Research Institute McMaster U. ON Various, incl. cutaneous, cancer Khan, Zia U. Western Ontario ON Various Ko, Frank U. British Columbia BC Various 3 131 3 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE RESEARCHERS 3c. Cont’d universitY/ institution provinCe U. Ottawa ON Various, incl. neurological, cardiovascular Kreplak, Laurent Dalhousie U. NS Various Krylov, Sergey N. York U. ON Various U. Laval QC Various U. Western Ontario ON Various; Proteomics researCHer researCH institution Kothary, Rashmi K. Ottawa Hospital Research Institute Lacroix, Dan LOEX Lajoie, Gilles Larouche, Danielle LOEX Legge, Raymond U. Laval QC Various U. Waterloo ON Various Levy, Gary Toronto General Research Institute, University Health Network U. Toronto ON Various, incl. immunological Marra, Marco BC Cancer Agency, Genome Sciences Centre U. British Columbia BC Various U. Manitoba MB Various Marshall, Aaron Massie, Bernard Associated with National Research Council— Biotechnology Research Institute U. Montréal QC Various, incl. hematological— hemophilia McBurney, Michael Ottawa Hospital Research Institute U. Ottawa ON Various—aging, cancer U. Alberta AB Various McGann, Locksley Earl McGuigan, Alison Institute of Biomaterials and Biomedical Engineering U. Toronto ON Various McInnes, Roderick Jewish General Hospital, Lady Davis Institute McGill U. QC Various, incl. eye McKerlie, Colin Samuel Lunenfeld Research Institute, Mount Sinai Hospital U. Toronto ON Various McNagny, Kelly Biomedical Research Centre U. British Columbia BC Various— allergy, asthma, cardiovascular, hematological, neurological U. Western Ontario ON Various Mequanint, Kibret 132 disease desCription Moffat, Jason The Donnelly Centre U. Toronto ON Various Mollica, Luigina Centre de recherche de l’Hôpital MaisonneuveRosemont U. Montréal QC Various Morris, Quaid The Donnelly Centre, Banting and Best Department of Medical Research U. Toronto ON Various Moulin, Véronique LOEX U. Laval QC Various appendiX 3C. RESEARCHERS ACCORDING TO DISEASE FOCUS universitY/ institution provinCe disease desCription U. Toronto ON Various, incl. cancer Opas, Michal J. U. Toronto ON Various— musculoskeletal, cardiovascular Park, Edward U. Victoria BC Various researCHer researCH institution Nagy, Andras Samuel Lunenfeld Research Institute, Mount Sinai Hospital and McEwen Centre for Regenerative Medicine, University Health Network Perkins, Theodore Sprott Center for Stem Cell Research, Ottawa Health Research Institute U. Ottawa ON Various Piret, James Michael Smith Laboratories U. British Columbia BC Various Queens U. ON Various U. Toronto ON Various, including diabetes Ramsay, Bruce Rogers, Ian Samuel Lunenfeld Research Institute, Mount Sinai Hospital Rossi, Fabio Biomedical Research Centre U. British Columbia BC Various Rottapel, Robert Ontario Cancer Institute, University Health Network U. Toronto ON Various Rudnicki, Michael Sprott Centre for Stem Cell Research, Ottawa Hospital Research Institute U. Ottawa ON Various, incl. neuromuscular Sabourin, Luc Ottawa Hospital Research Institute U. Ottawa ON Various Santamaria, Pere U. Calgary AB Various, incl. immunological, metabolic—diabetes Savard, Pierre U. Laval QC Various U. Toronto ON Various Seguin, Cheryle U. Western Ontario ON Various, incl. metabolic, musculoskeletal, embryogenesis Sen, Arindom U. Calgary AB Various Sheardown, Heather McMaster U. ON Various—eye, cardiovascular U. Toronto ON Various—neurological: Spinal cord injury, eye; Cancer Simmons, Craig U. Toronto ON Various—cardiology; Musculoskeletal— bone Skerjanc, Ilona Sylvia U. Ottawa ON Various— cardiovascular, musculoskeletal Sefton, Michael Shoichet, Molly The Donnelly Centre McEwen Centre for Regenerative Medicine, Toronto General Research Institute, University Health Network 3 133 3 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE RESEARCHERS 3c. Cont’d universitY/ institution provinCe Stanford, William U. Toronto ON Various, incl. musculoskeletal— osteoporosis Sun, Yu U. Toronto ON Various U. British Columbia BC Various Tyndale, Rachel U. Toronto ON Various Unsworth, Larry U. Alberta AB Various Vincent, Michel U. Laval QC Various— cardiovascular, musculoskeletal Walus, Konrad U. British Columbia BC Various— musculoskeletal, cutaneous Wang, Lisheng U. Ottawa ON Various Wertheimer, Michel Robert École polytechnique de Montréal QC Various researCHer Turner, Robin researCH institution Michael Smith Laboratories Woodgett, James Samuel Lunenfeld Research Institute, Mount Sinai Hospital U. Toronto ON Various, incl. cancer, metabolic—diabetes, neurological Yip, Christopher The Donnelly Centre U. Toronto ON Various Zandstra, Peter McEwen Centre for Regenerative Medicine, University Health Network and Institute of Biomaterials and Biomedical Engineering, Donnelly Centre U. Toronto ON Various, incl. hematological U. Laval QC Various U. British Columbia BC Various Zhang, Ze Ziltener, Hermann Johann 134 disease desCription Biomedical Research Centre appendiX 3D. EXAMPLES OF RESEARCHERS WORKING IN TRANSLATIONAL MEDICINE AND/OR CLINICAL TRIALS 3 3d. Examples of Researchers Working in Translational Medicine and/or Clinical Trials researCHer Atkins, Harry researCH institution universitY/ institution provinCe tYpe of regen. Med disease Sprott Centre for Stem Cell Research, Ottawa Health Research Institute U. Ottawa ON Stem cells—hematopoietic Various, incl. cancer— hematopoietic, neurological—MS U. Toronto ON Stem cells—mesenchymal Musculoskeletal Aubin, Jane Behie, Leo Includes: Pharmaceutical Production Research Facility U. Calgary AB Bioprocessing—stem cells production/ culture Various—neurological, metabolic—diabetes Berthod, François LOEX U. Laval QC Tissue engineering—stem cells Various, incl. neurological, urological, cutaneous Bramson, Jonathan McMaster U. ON Stem cells—cancer Cancer Couban, Stephen Dalhousie U. NS Stem cells—cord blood Cancer— hematological Courtman, David Sprott Centre for Stem Cell Research, Ottawa Hospital Research Institute U. Ottawa ON Stem cells—adult— endothelial progenitor Cardiopulmonary Crump, Michael A. Ontario Cancer Institute, University Health Network U. Toronto ON Stem cells—hematopoietic Cancer—lymphoma Dekaban, Gregory John P. Robarts Research Institute U. Western Ontario ON Stem cells—unspecified Neurological—spinal cord injury U. Toronto ON Stem cells—hematopoietic Cancer Doyle, John Drouin, Jacques Institut de recherches cliniques de Montréal U. Montréal QC Stem cells—fetal Neurological— Parkinson’s Gassas, Adam Hospital for Sick Children U. Toronto ON Stem cells—hematopoietic Cancer—leukemia Griffith, May Sprott Centre for Stem Cell Research, Ottawa Health Research Institute U. Ottawa ON Biomaterials—scaffolds; Tissue engineering—stem cells Eye Kaplan, David Hospital for Sick Children U. Toronto ON Stem cells—cancer Cancer U. Toronto ON Stem cells—bone marrow— mesenchymal, hematopoietic Cancer— hematological U. Toronto ON Stem cells—unspecified Cancer— hematological U. British Columbia BC Stem cells—unspecified Neurological—spinal cord injury U. Laval QC Stem cells—hematopoietic Cancer Keating, Armand Kuruvilla, John Ontario Cancer Institute, University Health Network Kwon, Brian Levesque, Eric Centre hospitalier de l’Université Laval 135 3 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE RESEARCHERS 3d. Cont’d researCHer Levy, Gary researCH institution universitY/ institution provinCe tYpe of regen. Med disease Toronto General Research Institute, University Health Network U. Toronto ON Stem cells—various— unspecified Various, incl. immunological Dalhousie U. NS Stem cells—fetal Neurological Mendez, Ivar Metz, Luanne Associated with Hotchkiss Brain Institute U. Calgary AB Stem cells—adult— endogenous progenitor Neurological—multiple sclerosis Miller, Freda McEwen Centre for Regenerative Medicine, Toronto General Research Institute, University Health Network U. Toronto ON Stem cells—various—dermal, neural Neurological, incl. spinal cord injury U. Toronto ON Stem cells—neural Neurological, other Morshead, Cindi Rogers, Ian Samuel Lunenfeld Research Institute, Mount Sinai Hospital U. Toronto ON Stem cells—various—cord blood, induced pluripotent, bone marrow Various, including diabetes Roy, Denis-Claude Centre de recherche de l’Hôpital MaisonneuveRosemont U. Montréal QC Stem cells—cancer Cancer—leukemia Schimmer, Aaron Ontario Cancer Institute, University Health Network U. Toronto ON Stem cells—cancer Cancer—leukemia Schultz, Kirk Child & Family Research Institute U. British Columbia BC Stem cells—hematopoietic Cancer—leukemia Schuurmans, Carol Associated with Hotchkiss Brain Institute U. Calgary AB Stem cells—unspecified Neurological—stroke, spinal cord injury, eye Slack, Ruth Ottawa Hospital Research Institute U. Ottawa ON Stem cells—unspecified Neurological Song, Kevin Vancouver Coastal Health Research Institute U. British Columbia BC Stem cells—hematopoietic Cancer—lymphoma Stewart, Duncan Sprott Centre for Stem Cell Research, Ottawa Health Research Institute U. Ottawa ON Stem cells—adult Cardiovascular Tannock, Ian Frederick Ontario Cancer Institute, University Health Network U. Toronto ON Stem cells—cancer Cancer Toze, Cynthia BC Cancer Agency U. British Columbia BC Stem cells—bone marrow Cancer— hematological U. Toronto ON Stem cells—neural Neurological development Tropepe, Vince 136 appendiX RESEARCH CENTRES LISTED BY PROVINCE researCH institution universitY/ institution provinCe tYpe of regen. Med disease Tsai, Eve Sprott Centre for Stem Cell Research, Ottawa Health Research Institute U. Ottawa ON Stem cells—unspecified Neurological—spinal cord injury van der Kooy, Derek McEwen Centre for Regenerative Medicine, Toronto General Research Institute, University Health Network U. Toronto ON Stem cells—neural (incl. retinal) Neurological—brain; Eye Wall, Donna Cancer Care Manitoba U. Manitoba MB Stem cells—hematological Cancer Weiss, Samuel Associated with Hotchkiss Brain Institute U. Calgary AB Stem cells—neural Neurological—brain, olfactory Wong, Peggy Hospital for Sick Children U. Toronto ON Stem cells—cancer Cancer—leukemia researCHer 4 appendiX 4 Research Centres Listed By Province provinCe/ universitY departMent/affiliated institution url alBerta U. Alberta # endoWed CHairs 37 5 # puBs/sCi. iMpaCt * All www.ualberta.ca 16 4 116/1.7 Alberta Diabetes Institute www.adi.med.ualberta.ca 1 0 N/A 15 4 Other U. Calgary # asset Map researCHers All www.ucalgary.ca 21 1 60/1.6 Hotchkiss Brain Institute www.hbi.ucalgary.ca 7 0 N/A Pharmaceutical Production Research Facility www.pprf.ca 2 1 N/A Southern Alberta Cancer Research Institute www.sacri.ucalgary.ca 1 0 N/A 11 0 53 8 Other BritisH ColuMBia Simon Fraser U. All www.sfu.ca 1 0 N/A U. British Columbia All www.ubc.ca 50 7 121/1.3 BC Cancer Agency (BCCA) (excl. Terry Fox Laboratory) www.bccancer.bc.ca 6 1 83/1.9 Biomedical Research Centre www.brc.ubc.ca 6 1 N/A Centre for Molecular Medicine & Therapeutics www.cmmt.ubc.ca 1 0 N/A Child & Family Research Institute www.cfri.ca 1 0 N/A iCapture www.icapture.ubc.ca 1 0 N/A Michael Smith Labs www.michaelsmith.ubc.ca 2 0 N/A 137 4 LIST OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE RESEARCH CENTRES appendiX 4 Cont’d provinCe/ universitY departMent/affiliated institution url # asset Map researCHers # endoWed CHairs # puBs/sCi. iMpaCt * Terry Fox Labs, BCCA www.terryfoxlab.ca 10 1 N/A Vancouver Coastal Health Research Institute www.vchri.ca 7 0 N/A 2 0 2 1 11 2 Other U. Victoria All www.uvic.ca ManitoBa U. Manitoba All www.umanitoba.ca 11 2 N/A Cancer Care Manitoba (incl. Institute of Cell Biology) www.cancercare.mb.ca; www.umanitoba.ca/institutes/ manitoba_institute_cell_biology 4 1 N/A 7 1 1 0 1 0 1 0 1 0 11 1 11 1 195 41 Other neW BrunsWiCK All (New Brunswick Heart Centre) www.ahsc.health.nb.ca neWfoundland & laBrador Memorial U. All www.mun.ca All www.dal.ca nova sCotia Dalhousie U. ontario N/A N/A N/A Carleton U. All www.carleton.ca 1 0 McMaster U. All www.mcmaster.ca 19 5 75/1.1 St. Joseph’s Hospital www.stjosham.on.ca 1 0 N/A Stem Cell and Cancer Research Institute (SCC-RI) sccri.mcmaster.ca 7 4 N/A 11 1 Other Queen’s U. All www.queensu.ca 9 1 N/A U. Guelph All www.uoguelph.ca 1 0 N/A U. Ottawa All www.uottawa.ca 34 9 N/A Ottawa Hospital Research Institute (OHRI) (excl. Sprott Centre) www.ohri.ca 5 1 N/A Sprott Centre for Stem Cell Research, OHRI www.ohri.ca/centres/ StemCellResearch 14 5 N/A University of Ottawa Heart Institute www.ottawaheart.ca 3 1 N/A Other U. Toronto 138 N/A 11 2 All www.utoronto.ca 110 24 173/1.5 McLaughlin-Rotman Centre for Global Health, University Health Network (UHN) www.mrcglobal.org 1 0 N/A Mount Sinai Hospital www.mountsinai.on.ca 1 0 N/A appendiX RESEARCH CENTRES LISTED BY PROVINCE provinCe/ universitY departMent/affiliated institution url # asset Map researCHers # endoWed CHairs # puBs/sCi. iMpaCt * The Donnelly Centre (Terrance Donnelly Centre for Cellular and Biomolecular Research) (incl. Banting and Best Department of Medical Research) thedonnellycentre.utoronto.ca 8 2 N/A Hospital for Sick Children www.sickkids.ca 16 4 47/1.2 Institute of Biomaterials and Biomedical Engineering www.ibbme.utoronto.ca 3 0 N/A McEwen Centre for Regenerative Medicine, Toronto General Research Institute, UHN www.mcewencentre.com 12 6 N/A Ontario Cancer Institute (Princess Margaret Hospital), UHN www.uhnresearch.ca/institutes/ oci 19 1 N/A Samuel Lunenfeld Research Institute, Mount Sinai Hospital www.lunenfeld.ca 8 3 N/A Sunnybrook Research Institute sunnybrook.ca/research 12 1 N/A Toronto General Research Institute (excl. McEwen Centre), UHN www.uhnres.utoronto.ca/ institutes/tgri 3 0 N/A 27 7 Other U. Waterloo All www.uwaterloo.ca 3 0 N/A U. Western Ontario All www.uwo.ca 17 1 N/A John P. Robarts Research Institute www.robarts.ca 4 1 N/A Lawson Health Research Institute, London Health Sciences Centre www.lawsonresearch.com 3 0 N/A London Regional Cancer Program, London Health Sciences Centre www.lrcc.on.ca 1 0 N/A 9 0 1 1 102 24 Other York U. All www.yorku.ca QueBeC N/A École polytechnique de Montréal All www.polymtl.ca 7 3 N/A McGill U. All www.mcgill.ca 33 8 89/1.1 Artificial Cells and Organs Research Centre www.medicine.mcgill.ca/artcell 1 0 N/A Jewish General Hospital incl. Lady Davis Institute for Medical Research www.jgh.ca 2 1 N/A 1 0 N/A 5 0 N/A 24 7 Montreal Neurological Institute The Research Institute of the McGill University Health Centre muhc.ca Other U. Laval All www.ulaval.ca 23 1 Centre hospitalier de l’Université Laval www.crchuq.ulaval.ca 4 0 4 N/A 139 4 LIST OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE RESEARCH CENTRES appendiX 4 Cont’d provinCe/ universitY departMent/affiliated institution url LOEX (Experimental Organogenesis Laboratory—Laboratoire d’organogénèse expérimentale) www.cha.quebec.qc.ca/en/ www/research/fields-ofresearch # asset Map researCHers # endoWed CHairs # puBs/sCi. iMpaCt * 10 1 N/A 9 0 www.loex.qc.ca Other U. Montreal All www.umontreal.ca 32 10 N/A Centre de recherche de l’Hôpital Maisonneuve-Rosemont recherche.maisonneuverosemont.org 3 2 N/A Centre de recherche du Centre hospitalier de l’Université de Montréal www.chumtl.qc.ca/crchum. en.html 3 0 N/A Hôpital Sainte-Justine www.chu-sainte-justine.org 2 0 N/A Institut de recherches cliniques de Montréal www.ircm.qc.ca 7 3 N/A Institute for Research in Immunology and Cancer www.iric.ca 3 3 N/A Montreal Heart Institute www.icm-mhi.org 2 0 N/A 10 2 Other U. Québec à Montréal All www.international.uqam.ca/ pages/anglais.aspx 3 1 N/A U. Sherbrooke All www.usherbrooke.ca 4 1 N/A 5 0 All www.usask.ca 5 0 sasKatCHeWan U. Saskatchewan N/A *Publications and scientific impact data were produced by Industry Canada in 2010 in a report titled Mapping Canadian BioPharmaceutical Assets. Data were collected from 1996–2009. For the Scientific Impact rating, the global average is 1.0. 140 appendiX REFERENCES AND NOTES general inforMation • US National Institutes of Health. Regenerative Medicine. Department of Health and Human Services. August 2006. stemcells.nih.gov/info/2006report/. Accessed January 21, 2011. 7 Canadian Scientists Transform Human Skin into Blood. www.canada.com/ story_print.html?id=3793787&sponsor=. Accessed November 24, 2010. 8 Editorial. Betting on HSC. Nature Immunology. 2002: 3. Cited in Stem Cell Network. Book Two: Strategic Plan for Second Funding Cycle 2007. Provided by Drew Lyall. 9 ISI index reference. Cited in Stem Cell Network. Book Two: Strategic Plan for Second Funding Cycle 2007. Provided by Drew Lyall. 10 Ontario’s MaRS Regenerative Medicine 2009 Industry Briefing report. www.marsdd.com/buzz/reports/ regenerativemedicine. Accessed November 17, 2010. 11 Technology, talent and capital: State Bioscience Initiatives 2008. Battelle Memorial Institute and Biotechnology Industry Organization. www.bio.org/ local/battelle2008/State_Bioscience_ Initiatives_2008.pdf. Accessed February 23, 2011. 12 States applaud new stem cell funding. March 11, 2009. www.stateline.org/live/ details/story?contentId=383210. Accessed February 23, 2011. 13 (1) See reference #11. Also (2) Fitzpatrick, Meagan. Canada’s mantle as stem-cell leader fading, experts warn. November 2, 2010. www.canada.com/ story_print.html?id=3766795&sponsor=. Accessed November 24, 2010. (3) Evidence to Standing Committee on endnotes 1 2 Stem Cell Basics. National Institutes of Health. stemcells.nih.gov/info/basics/. Accessed January 21, 2011. Till, JE, McCulloch, EA. A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. Radiation Res. 1961; 14, 213–222; Becker AJ, McCulloch EA, Till JE. Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow cells. Nature. 1963; 197:452–454. 3 Stem Cell Network. Book Two: Strategic Plan for Second Funding Cycle 2007. Provided by Drew Lyall. 4 www.stemcellnetwork.ca. Accessed December 16, 2010. 5 (1) www.stemcellnetwork.ca. Accessed December 16, 2010; (2) Lyall, A, Isasi, R. Stem Cell Research: Perspectives from Canada. World Stem Cell Report 2010. Chapter 11. pp. 173–177. www. worldstemcellsummit.com/node/663. Accessed December 16, 2010. (3) Industry Canada. 6 (1) Stem Cell Network. Book Two: Strategic Plan for Second Funding Cycle 2007. Provided by Drew Lyall. (2) Industry Canada. 5 141 5 LIST OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE RESEARCH CENTRES Health Nov 2, 2010. www2.parl.gc.ca/ HousePublications/Publication.aspx?L anguage=E&Mode=1&Parl=40&Ses= 3&DocId=4750819&File=0. Accessed December 15, 2010. 14 All NCE funds were dedicated to U. Ottawa where the Stem Cell Network (SCN) is located. A breakdown of funds according to SCN grants across Canada would have made some difference to provincial and university funding (Figures 2 and 3), although this generally would not have been significant except for U. Ottawa. Even so, this university would still have ranked among the top five. 15 Stem Cell Basics. National Institutes of Health. stemcells.nih.gov/info/basics/. Accessed January 21, 2011. 16 142 Shapiro, A.M., J.R. Lakey, E.A. Ryan, et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med. 2000; 343:230– 38. Cited in Lyall, A. Investment Models 3: Public Investment In Stem Cell Research In Canada. 17 Stem Cell Network. Stem cells for the treatment of Parkinson’s disease project. www.stemcellnetwork.ca. Accessed February 7, 2011. 18 www.suite101.com/content/ cord-blood-banking-universityresearch-in-canada-a274345; www. cordbloodassociationofcanada.com/ Cord_Blood_Banking.php; Accessed January 28, 2011. 19 v(1) www.canada.com/health/Funding +only+remaining+obstacle+national +cord+blood+bank/3877607 /story. html#ixzz16EF5Hh40. Accessed January 28, 2011. (2) Evidence to Standing Committee on Health Nov 2, 2010. www2.parl.gc.ca/ HousePublications/Publication.aspx? Language=E&Mode=1&Parl=40&Ses= 3&DocId=4750819&File=0. Accessed December 15, 2010. Note: there was an announcement on March 14, 2011 that governments had agreed to fund a national blood bank with $48 million over the next 9 years with operations expected from 2013. See “National cord blood bank to get $48M”. CBC News March 14, 2011. www.cbc.ca. Accessed March 17, 2011. 20 www.bccancer.bc.ca/NR/rdonlyres/ 41981E57-778D-4E85-82E258D8EE5C16D8/33204/Headlines_ Spring_2009.pdf. Accessed February 3, 2011. 21 Ontario’s MaRS Regenerative Medicine Asset Map 2009. www.trra.ca/en/sectors/ resources/MRI_asset_maps_RM_050809. pdf. Accessed December 15, 2010. 22 Stem Cell Banks, Libraries and Registries. Stem Cell Network. (Page 4). www. stemcellnetwork.ca/uploads/File/ whitepapers/Stem-Cell-Banks-Librariesand-Registries.pdf. Accessed February 3, 2011. 23 Ontario’s MaRS Regenerative Medicine Asset Map 2009. www.trra.ca/en/sectors/ resources/MRI_asset_maps_RM_050809. pdf. Accessed December 15, 2010. appendiX REFERENCES AND NOTES 24 www.nce-rce.gc.ca/Media-Medias/newscommuniques/News-Communique_eng. asp?ID=93. Accessed January 10, 2011. 25 www.cancerstemcellconsortium.com/ uploads/PDFs/CSCC.Full.Str.Plan FINAL REVISED 18 November 2008_Corrected Date.pdf. Accessed January 10, 2011. 26 Information from: stemcells. nih.gov/research/intlresearch. asp, www.vr.se/inenglish/aboutus/ internationalcollaboration/ globalcollaboration/international stemcellforumiscf.4.aad30e310ab cb9735780006480.html. Accessed February 3, 2011. 29 Canadian Scientists Transform Human Skin into Blood. www.canada.com/ story_print.html?id=3793787&sponsor=. Accessed November 24, 2010. 30 Ontario—a leading centre of stem cell research. Biotechnology Focus. 2008; June: 22–25. 27 Data were obtained from the first 50 hits from Google searches naming province, “research network”, or “research group”. 31 28 (1) Mapping Canadian BioPharmaceutical Assets: Academic and Hospital Research Institutes (September 2010), internal document provided by Life Science Industries Branch at Industry Canada. Citation data source: Scopus, Website: www.scopus.com. Explanation: Researchers were selected using a formula based on number of papers and citation counts in regenerative medicine and stem cells from 2005 to 2010. Self-citations were excluded. Citation index (h-index) quantifies the impact of a researcher’s publications. So an h-index of 16 means that the top 16 of a researcher’s articles were cited 16 or more times; an h-index of 12 means that the top 12 articles were cited 12 or more times (Research Performance Measurement: Introducing the SciVerse Scopus h-index). Report published August 2007. www.info. Nagy, A., J. Rossant, R. Nagy, et al. Derivation of completely cell culturederived mice from early-passage embryonic stem cells. Proc Natl Acad Sci USA. 1993; 90(18): 8424–28. Cited in Lyall, A. Investment Models 3: Public Investment In Stem Cell Research In Canada. 32 Nagy, A., J. Rossant, R. Nagy, et al. Derivation of completely cell culturederived mice from early-passage embryonic stem cells. Proc Natl Acad Sci U S A. 1993; 90(18): 8424–28. Cited in Lyall, A. Investment Models 3: Public Investment In Stem Cell Research In Canada. 33 Mapping Canadian BioPharmaceutical Assets: Academic and Hospital Research Institutes (September 2010), internal document provided by Industry Canada’s Life Science Industries Branch. 5 sciverse.com/UserFiles/2508.SciVerse. Research Performance Measurement(LR). pdf. Accessed January 11, 2011). (2) Report by Science-Metrix for Industry Canada 2010: Performance of Canadian Biopharmaceutical Organizations: A Scientometric and Technometric Analysis (1996–2009), dated March 31, 2010. 143 appendiX 4A. RESEARCHERS IN ALPHABETICAL ORDER 4 145
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