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How are substances
secreted into nephrons?
Goals:
Remove more of filtered
substances (H+, HCO3-)
Remove un-filtered
substances (drugs)!
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1-2 minutes: increase
RR & tidal volume!
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%
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1st buffers
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"%
1-2 minutes: decrease
Chronic Acidosis can
inhibit CNS, muscles.
RR & tidal volume!
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%
%
pH < 7.0 can be fatal.
1st buffers
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1-2 hrs: increase
renal H+ secretion
& reabsorb HCO3:%
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Chronic Alkalosis can cause
muscle tetany, seizures
pH < 7.0 can be fatal.
1-2 hrs: increase
renal HCO3- secretion
& reabsorb H+
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