FUNDING OPPORTUNITY ANNOUNCEMENT The Scott & White Research Grants Program March, 2012 1 The Scott & White Research Grants Program The Research Grants Program (RGP) is an intramural funding mechanism that supports scientific research at Scott & White. The program is specifically designed to: 1) fund pilot research projects, 2) foster research training experience for TAMU medical students, S&W residents, fellows, and other healthcare professionals, and 3) enhance the academic environment with innovative and interdisciplinary research. The program is focusing emphasis upon and support to translational research, projects aimed at moving basic research findings into clinical applications for reducing incidence, morbidity, or mortality. For further discussion on the translational research, please see the section entitled ‘Translational Research’ on next page. Award Categories Research Advancement Award (up to $50,000): The purpose of this award is to facilitate new research initiatives and collaborations by funding pilot projects with a potential for extramural funding and publication of scientific data. Scott & White Healthcare System staff and Texas A&M College of Medicine faculty, when in collaboration with a S&W staff member or trainee, are eligible for this award. Research Vision Award (up to $80,000): The purpose of this award is to promote multi-disciplinary collaboration and involvement of multiple trainees. This project should have the potential to generate extramural funding by development into center grants, program projects or training grants. Eligibility for this award is the same as for the Research Advancement Award, with additional review criteria. Note: A Principal investigator (PI) may not have more than one funded grant in each category, at any time. March, 2012 2 Translational Research The RGP requires investigators to categorize their application into one of the following areas of translational research. Translational Research is divided in two phases: Phase I: Phase I research involves “transfer of new understandings of disease mechanisms gained in the laboratory into the development of new methods for diagnosis, therapy, and prevention and their first testing in humans”.1 This requires expertise in basic sciences such as molecular and cell biology, and genetics. Phase I is further divided into two parts, Type 1 (T1) and Type 2 (T2). T1 research moves a basic discovery into a candidate health application. T2 research assesses the value of T1 application for health practice leading to the development of evidence-based guidelines. Phase II: Phase II research is “the translation of results from clinical studies into everyday clinical practice and health decision making”.1 Phase II research is performed in community and healthcare settings where population based interventions and practice based research bring the results of phase I results to public. This requires expertise in disseminating and evaluating interventions in the real world settings. Phase II is further divided into two parts, Type 3 (T3) and Type 4 (T4). T3 moves evidencebased guidelines into health practice, through delivery, dissemination, and diffusion research. T4 research involves "moving scientific knowledge into the public sector, evaluate the "real world" health outcomes of a T1 application in practice and thereby changing people’s everyday lives”. Figure: Translational Research: From Basic Discovery to Population Health3 References: 1. Woolf, S.H. (2008). The Meaning of Translational Research and Why It Matters. JAMA, 299(2), 211-213. 2. Kon, A.A. (2008). The Clinical and Translational Science Award (CTSA) Consortium and the Translational Research Model. The American Journal of Bioethics, 8(3), 58-60. 3. What is Translational Research? www.utsouthwestern.edu/utsw/cda/dept440996/.../489751.html March, 2012 3 Scott & White Research Grants Program Overview of Funding Opportunities Award Research Advancement Award Research Vision Award Amount up to $50,000 up to $80,000 Eligibility ●Scott & White staff. ●Texas A&M College of Medicine faculty members when in collaboration with a Scott & White member or trainee Limit one active RGP award per category per Principal Investigator Three cycles each fiscal year. Award Cycles Submission Deadlines: September 14, 2011 January 13, 2012 May 14, 2012 Letter of Intent (LOI) Applicants MUST submit a Letter of Intent, no later than 30 days prior to submission deadline, to Jessica Rostockyj, RGP Grants Coordinator, at [email protected]. A sample format for the letter is provided at end of this document. Format for Research Plan Grant applications must be single spaced with 0.5 inch margins. Use Arial text and a font size of 11 or larger. (Details on Pg 9) Figures, charts, and tables may be smaller in font size and should be embedded within the text, in black ink, and readily legible. These DO count toward page limit. Appendices (limit 5) may be included but may not be used as a means to circumvent research page limits. There are no font or page limitations on appendices. Assistance with proposal development is available through the Office of Scientific Investigator Development (Sandhya Sanghi, PhD, MPH, 771-4831). Dr. Sanghi provides input regarding proposal content, and also provides pre-submission comments for draft proposals. Research Plan Guidelines 1) Abstract (200 words or less, not included in page limit) 2) Specific Aims (one page limit) 3) Research Strategy (limit six page for advancement and ten pages for vision awards): March, 2012 o Significance o Innovation o Approach 4 To be included with Research Plan, but does not count toward page limit: Literature Cited Human Subjects Research (if applicable) Resources (list those currently available for the applicant’s use in the proposed project) Resubmission Key Items to be Addressed in the Research Plan Provide an Introduction (limited to single page) that addresses the previous peer review critique How is the project innovative? How will the project advance the PI’s/co-PI’s research career(s)? How will this project lead to new research projects or contribute to the development of an existing research program? Delineate specific role of trainees. For Vision awards only: How will this project move beyond a successful Vision Award to a large scale competitive extramural grant application (e.g. Program Project or Center Grant)? These must be apparent and reasonable goals of the project. Indicate meaningful collaborations across multiple departments and/or institutions (e.g. co-PI’s are encouraged). Key Principles of the Grants Mechanism Priority will be given to innovative projects that include junior faculty and S&W trainees. Projects should have the potential to produce novel discoveries which can be developed into new programs and/or proposals for extramural funding. Interdisciplinary investigative teams are encouraged, including collaborations outside of Scott & White. Data collection must be completed within two years from time of funding. An additional 6 months can be requested for analysis and manuscript development. Proposed budgets must be well justified. Timelines must include milestones that mark progress towards project aims. Project completion must be feasible within the proposed timeline. Protected time commensurate with participating clinicians’ percent effort must be approved by the appropriate Department Chairs. In addition, those applying for the Research Vision Award should: Include collaborative efforts among faculty from different institutions, departments, or research institutes. March, 2012 5 Provide significant training experiences for multiple S&W trainees. Provide evidence that project findings will have the potential to contribute to the development of center grants, program projects, or training grants. Provide evidence that the project has the potential to bring recognition for S&W research excellence. Application Requirements (Details on Pg 8) Documentation to be sent to RGP Coordinator: Research Plan Detailed Budget and Budget Justification for all years of the project NIH biographical sketches for Key Study Personnel (PI, Co -PIs, Sub-Investigators, Consultants, and Collaborators) Appendices (limit 5) Letters of support from the PI’s, Co-PI’s, Consultants’ and Collaborators. For clinical participants, a letter of support from their Department Chairs, including stated approval of protected time commensurate with the participant’s percent effort. Additional supporting documentation. Compilation for submission: Assemble the following documents in the order given below and email as a single file titled “Research Plan”: 1. Abstract (maximum 200 words) 2. Introduction (resubmission only) 3. Specific Aims (one page limit) 4. Research Strategy (follow page limit) 5. Human Subjects (if applicable) 6. Literature Cited 7. Resources Email the budget and budget justification as a single file. Email NIH biosketches as separate files, titled using the appropriate investigator’s name. Email letters of support and other supporting documents as appendices (limit 5). Review Process (Details on Pg 14) Standard NIH review criteria will be applied and applicants will receive a Scientific Merit Priority Score based on: 1. Significance of the topic/ contribution to the field 2. Investigator/ Mentor’s qualifications March, 2012 6 3. Innovation/novel concepts or ideas 4. Approach (e.g. aims, design, methodology) 5. Environment (evidence of necessary support) In addition to the standard NIH review criteria, applications will be reviewed according to the project’s alignment with the purpose and priorities of the Scott & White Research Grants Program. See page 15 for criteria specific to Research Advancement and Research Vision Awards. In general, this will include: Potential for interdisciplinary and inter-institutional collaboration. Novel discovery with the potential for extramural funding. Potential for career or institutional advancement. Involvement of junior faculty or S&W trainees. Feasibility of completion based on time commitment of the PI and available resources. Budget justification and timeline. Applications are evaluated on scientific and technical merit by two internal reviewers and a reader. One external reviewer (outside the S&W/TAMU systems) can be assigned at the discretion of the RGP Chair. March, 2012 7 Application Guidelines Applicants MUST submit a Letter of Intent no later than 30 days prior to submission deadline (see page 19 for template and instructions). Contact Jessica Rostockyj, Grants Coordinator, at 7714842 or [email protected] to ask questions or obtain program assistance. Electronic Submission Electronic submission is mandatory for all awards. Required documents must be emailed to the RGP Coordinator by the due date for submission to the Scott & White Research Grants Program for funding consideration. Incomplete applications will be administratively withdrawn. RGP applicants must adhere to the following pre-submission process (list of contacts appears at the end of this document): Biostatistics Consultation. Investigators must consult with a S&W biostatistician to discuss the experimental design to be employed. This consultation will determine the study’s sample size requirements and the statistical test to be used in the eventual analysis of the study data. Contact Holly Hall ([email protected]) to schedule an appointment with either Dr. Juhee Song or Dr. Chanhee Jo. Research Feasibility Analysis (human subject research only). For human subject research (prospective and retrospective), feasibility analysis is required following consultation with Biostatistics to assess patient populations for the project plan. Adequate patient populations can determine the success or failure of a clinical research project. No project involving human subject research will receive approval from the RGP unless feasibility is performed prior to submission. Budget and Budget Justification Consultation. An “NIH style” budget is expected for all applications. The budget justification should list all key personnel (KSP) contributing to the project, starting with the principal investigator. Include names, position, percent effort and specific role on the project. Indirect cost will not be paid (see page 18 for allowable expenses). All budgets and budget justifications must be generated via consultation with the Research Finance office before proposal submission. NOTE: Feasibility analysis and budgets for human subject studies are initiated by RGP Coordinator Jessica Rostockyj, who will schedule a meeting with appropriate staff following investigator consultation with Biostatistics. Consultation during Proposal Development. Investigators are welcome to discuss their project before or during project development with Research Proposal Development Specialist Dr. Sandhya Sanghi (7714831) or [email protected]. March, 2012 8 All applications to the RGP must include the following: Abstract. Provide a written abstract of no more than 200 words that briefly synopsizes the proposed project. It will be used in the assignment of applications for review. The Abstract does not count toward the Research Plan page limit. Include the following information: A statement of specific aims Methods or techniques to be used, including the proposed research model (animal/human/tissue culture, etc.) End points or objectives to be achieved Introduction. The Introduction is a required component for resubmissions. Each application is permitted only one resubmission. The Introduction must include responses to the issues and criticisms raised by the reviewers. Applicants may submit a resubmission application, but such application must include an Introduction addressing the previous peer review critique The Introduction must also summarize any substantial additions, deletions or changes to the application. Substantial scientific changes must be marked in the text of the application by bracketing, indenting, or change of typography. Do not underline or shade the changes. The Introduction should be placed before the specific page section. The Introduction is limited to 1 page. The Introduction does not count toward the Research Strategy page limit. Proposed Research Plan. The Research Plan has two components. 1. Specific Aims (limited to one page) 2. Research Strategy: Maximum page limit for the research strategy is based on the type of research award: Research Advancement Award - maximum of 6 pages Research Vision Award - maximum of 10 pages Format requirements for the research plan (including resubmission modifications, if applicable) are: • 0.5” margins • Single spaced • Arial font style, 11 point or larger* *Figures, charts, tables, and figure legends may be smaller in size but must be clear and legible. They should be embedded within the text and do count toward page limit. Applications exceeding the specified page limits and/or not adhering to format requirements may be administratively withdrawn. Appendices may be sent as separate documents (limit of 5) but may not be used as a means to circumvent research page limits. There are no font or page limitations on appendices. March, 2012 9 Typically, the research plan should include the following components: Specific Aims. The Specific Aims section is limited to 1 page and is the most important section of the research plan. This section should provide a succinct overview of the project and contain a brief background, justification for additional studies, statement of hypothesis, experimental approach, significance, and a summary sentence. Include a clear, concise list of the aims of the proposed work and its relationship to long term goals (e.g. to test a stated hypothesis, create a novel design, solve a specific problem, challenge an existing paradigm or clinical practice, address a critical barrier to progress in the field, or develop a new technology). Summarize the expected outcome(s), including the impact that results of the proposed research will exert on the research field(s) involved. Research Strategy (follow page limits). Organize the Research Strategy in the order specified below, using the instructions provided. Begin each section with the appropriate section heading – Significance, Innovation, Approach. Cite published experimental details in the Research Strategy section and provide the full reference in the Literature Cited section. (a) Significance Explain the importance of the problem or critical barrier to progress in the field that the proposed project addresses. Explain how the proposed project will improve scientific knowledge, technical capability, and/or clinical practice in one or more broad fields. Describe how the concepts, methods, technologies, treatments, services, or preventative interventions that drive this field will be changed if the proposed aims are achieved. (b) Innovation Explain how the application challenges and seeks to shift current research or clinical practice paradigms. Describe any novel theoretical concepts, approaches or methodologies, instrumentation or interventions to be developed or used, and any advantage over existing methodologies, instrumentation, or interventions. Explain any refinements, improvements, or new applications of theoretical concepts, approaches or methodologies, instrumentation, or interventions. (c) Approach Describe the overall strategy, methodology, and analyses to be used to accomplish the specific aims of the project. Include how the data will be collected, analyzed, and interpreted as well as any resource sharing plans as appropriate. Discuss potential problems, alternative strategies, and benchmarks for success anticipated to achieve the aims. If the project is in the early stages of development, describe any strategy to establish feasibility, and address the management of any high risk aspects of the proposed work. Point out any procedures, situations, or materials that may be hazardous to personnel and precautions to be exercised. Note: If a project has multiple Specific Aims, then the proposal may address Significance, Innovation and Approach for each Specific Aim individually, or it may address Significance, Innovation and Approach for all of the Specific Aims collectively. March, 2012 10 As applicable, also include the preliminary studies as part of the Research Strategy, keeping within the three sections listed above (Significance, Innovation, and Approach). Discuss the PI’s preliminary studies, data, and or experience pertinent to the application. Preliminary data can be an essential part of a research grant application and helps to establish the likelihood of success of the proposed project. Human Subjects Research. If the proposed research project involves human subjects, the population sampled shall be inclusive of the general population; of relevance to the scientific question posed; and without restriction in regard to gender, race, age, and socioeconomic status. Proposals that intentionally restrict the population sampled must include a compelling scientific rationale for such research design. The Human Subjects portion of the Research Plan must provide the following information for all projects involving human subjects (not included in Research Plan page limit): 1. Risk to Human subjects a. Human subjects involvement and characteristics Describe the proposed involvement of human subjects in the work outlined in the Research Design and Methods section. Describe the characteristics of the subject population including their anticipated number, age range, and health status. Identify the criteria for inclusion/exclusion of any subpopulation. Explain the rationale for involvement of special classes of subjects, such as fetuses, neonates, pregnant women, children, prisoners, institutionalized individuals, or others who may be considered vulnerable populations. List any collaborating sites where human subjects research will be performed, and describe the role of those sites and collaborating investigators in performing the proposed research. b. Sources of materials Describe the research material obtained from living individuals in the form of specimens, records, or data. Describe any data that will be collected from human subjects for the project(s) described in the application. Indicate who will have access to individually identifiable private information about human subjects. Provide information about how the specimens, records, or data are collected and whether material or data will be collected specifically for the proposed research project. c. Potential risks Describe the potential risks to subjects (physical, psychological, financial, legal, or other) and assess their likelihood and seriousness to the subjects. Where appropriate, describe alternative treatments and procedures, including the risks and potential benefits of the alternative treatments and procedures to participants in the proposed research. 2. Adequacy of Protection Against Risks a. Recruitment and informed consent Describe plans for the recruitment of subjects (where appropriate) and the process for obtaining informed consent. If the proposed studies will include children, describe the process for meeting requirements for parental permission and child assent. Include a description of the circumstances under which consent will be sought and obtained, who will seek it, the nature of the information to be provided to prospective subjects, and the method March, 2012 11 of documenting consent. If a waiver of some or all of the elements of informed consent will be sought, provide justification for the waiver. b. Protections against risk Describe planned procedures for protecting against or minimizing potential risks including risks to the privacy of individuals or confidentiality of data, and assess their likely effectiveness. 3. Potential Benefits of the Proposed Research to Human Subjects and Others Discuss the potential benefits of the research to research participants and others. Discuss why the risks to subjects are reasonable in relation to the anticipated benefits to research participants and others. 4. Importance of the Knowledge to be Gained Discuss the importance of the knowledge to be gained as a result of the proposed research. Discuss why the risks to subjects are reasonable in relation to the importance of the knowledge that reasonably may be expected to result. NIH Biosketches for PI and Key Study Personnel. Provide biosketches for the PI and key study personnel in current NIH format. Key study personnel are defined as individuals who contribute in a substantive way to the scientific development or execution of the project, whether or not salaries are requested. The “Research Support” portion of the biosketch must include a list of research study titles with dollar amounts and sources of current, pending, & expired funding for the prior three years. You may contact Jessica Rostockyj at 254-771-4842 or [email protected] for assistance with conversion of your CV to NIH format biosketch. Literature Cited or References. This section is not included in the Research Plan page limit. Include complete details of all references, including article authors and titles. List sources numerically, either in order of citation in the text or alphabetically. Resources. Provide a list of resources such as space, personnel, equipment, and core facilities available to the investigator to successfully perform the proposed study. This section is not included in page limit. Compilation for Submission. Assemble the following documents in the order given below and email as a single file titled “Research Plan”: 1) Abstract (maximum 200 words) 2) Introduction (resubmissions only) 3) Specific Aims (one page limit) 4) Research Strategy (follow page limit) 5) Human Subjects (if applicable) 6) Literature Cited 7) Resources Email the budget and budget justification as a single file. Email NIH biosketches as separate files, each titled using the appropriate investigator’s name. Email appendices (limit 5 including letters of support and other supporting documents) as separate files. March, 2012 12 Peer Review Process The goal of the RGP committee is to fund scientifically meritorious applications that are relevant to healthcare. Peer review is the cornerstone of this program and occurs in two stages. During the first stage, applications are evaluated on scientific merit by at least two internal reviewers and a reader. One external reviewer (outside the S&W/TAMU systems) may be assigned at the discretion of the RGP Chair. Reviewers are expected to: 1) Write a critique of the application, 2) Assign an overall impact score, and 3) Make an oral presentation of their written critique to the full RGP committee. The reader's responsibility is to provide their perspective on the grant idea and whether they could see it possibly advancing the scientific field or reaching the clinic in the future. Readers do not need to focus on techniques or methodology, etc., just the grantsmanship and ideas. Beginning in FY 2012, the RGP has formed two peer review groups (i.e., study sections). Applications categorized as T1 and T2 are reviewed by the Phase I Translational Review Group consisting primarily of basic scientists and secondarily of clinical scientists, with specific expertise in T1 or T2 research. Applications categorized as T3 and T4 are reviewed by the Phase II Translational Review Group consisting primarily of clinical and outcomes research scientists and secondarily by basic scientists, with specific expertise in T3 and T4 research. The readers for Phase I projects are primarily clinicians and for Phase II study, largely bench researchers. Each reviewer’s overall impact priority score is determined by consideration of the five review criteria defined by NIH review guidelines. Additional criteria are used in reviewing the applications to make sure that the project aligns with the priorities and purposes of RGP (see below). Priority scores range from 1.0 (highest priority) to 9.0 (lowest priority). At the committee meeting, all eligible members (those without conflict of interest) provide additional critiques and assign a priority score to the grant application under review. The final priority score is an average of the scores given by the committee member, multiplied by 10. The second stage of peer review determines which applications are funded. After peer review and scoring by the review group, applications are reviewed for funding by a committee composed of the chair of the RGP, the chairs of each review group and a representative of each review group. The funding process is highly competitive and is based on availability of funds from Institutional Research Funds (IRF), application priority scores, and additional criteria such as alignment of the research with the Scott & White Mission and Vision. All applicants will receive notification of their overall impact priority scores along with a written critique. Applications that are not funded are allowed one resubmission. Criteria for Reviewers: RGP’s five core review criteria are the same as those applied in competition for NIH funding. These criteria will be scored individually on the 9-point scale described above. Significance: Does this study address an important topic or critical barrier to progress in the field? How will achievement of the project’s aims advance scientific knowledge or clinical practice? What effect will this study have on the concepts, methods, and technologies that drive this field? Investigators: Are the PI, co-PI, collaborators, and other researchers well suited to carry out this March, 2012 13 work? Do new investigators have appropriate experience and training? Do established investigators demonstrate an ongoing record of accomplishments that has advanced their field? For a collaborative, multi-PI project, does the investigative team have complementary and integrated expertise? Innovations: Does the project employ novel concepts, approaches, or methods? Are its aims original and innovative? Does it challenge existing paradigms or develop new methodologies or technologies? Approach: Are the conceptual framework, design, methods, and analyses adequately developed, well integrated, and appropriate to the aims of the project? The assessment of preliminary data should be put into perspective such that bold new ideas and risk-taking on the part of beginning investigators are encouraged rather than stymied. Does the applicant acknowledge potential problem areas and consider alternative tactics? Environment: Are available resources adequate in terms of institutional support, equipment and other physical resources? Will the working environment contribute to the probability of success? What are the unique features of the scientific environment, subject populations, or collaborative arrangements? Is there evidence of institutional support as demonstrated in the department head’s letter? Additional review considerations for all award levels The following additional items are relevant in determining the scientific merit of an application but are not assigned specific scores; they should, however, be considered when assigning the overall priority score: For a project involving clinical research, are there any plans for protection of human subjects from research risks? Are study population inclusion /exclusion criteria justified in terms of the scientific goals and research strategy proposed? For animal research, has the applicant addressed animal welfare and biohazard issues? Has a plan for data sharing been addressed? Has a plan for sharing of model organisms and resources been addressed? Is the budget appropriate for the proposed work? Feasibility of completion based on PI time commitment and available resources Budget justification and feasibility of timeline Additional review criteria for Research Advancement Award The RGP review committee will consider the following additional criteria when assigning overall impact score for Research Advancement Award applications: Potential for interdisciplinary and inter-institutional collaboration Potential for extramural funding Potential for advancement of the PI’s research career Involvement of junior faculty and trainees, with detailed explanation of specific roles Additional review criteria for Research Vision Award The following criteria will also be considered when scoring Research Vision Award applications: Demonstrates inter-institutional and interdisciplinary collaborative efforts Potential for the project to grow into a significant proposal for external funding, such as a center grant, program project, or training grant Involvement of multiple S&W trainees, with detailed explanation of specific roles. Likelihood of the research bringing recognition for S&W research excellence March, 2012 14 Scoring of the Application: Scoring will be based on a 9-point rating scale (1 = exceptional; 9 = poor). Only integers will be used in the scoring. Each scientific review criteria delineated above will receive an individual score. A final priority score will reflect the overall impact the project is likely to have on the research field involved. Final priority scores are not an average or summation of individual scores; instead, judgment is used in weighing the relative importance of the criteria. An application need not be strong in all categories to have major scientific merit. For example, a researcher may propose to carry out important work that by its nature is not innovative but is essential for the field advancement. Unacceptable designations in the areas of protection of human subjects from research risk; inclusion/exclusion of gender, minorities, or children, vertebrate animal welfare and biohazards should be reflected in overall priority scores. The applications strong in RGP Alignment but weak in Scientific Merit will not be considered, as sound science remains the pillar of this grant mechanism. The Written Critique: Written critiques are expected to consider all aspects of the application. Reviewers must provide a brief summary of the project. Evaluative statements about the strengths and weaknesses based on review criteria are core to the written critique. Ideally, reviews put the strengths and weaknesses of the application in perspective by indicating their relative magnitude. Summarize study’s major strengths and weaknesses at the end of the evaluation. Critiques are best written in concise and bulleted form. Focus on minor technical details, tutorial comments, or efforts to redesign the investigator's experiments should be avoided. A hypothesis-driven approach is not absolutely required if the research is sound and will advance the field. Discussion of the Application: The Chair of the review committee will guide the scientific discussion. The assigned reviewers are expected to clearly summarize their reviews, briefly describing the project’s overall goals and emphasizing its major strengths and weaknesses for the benefit of committee members who are less familiar with the proposal. Secondary reviewer should avoid repeating detailed descriptions of strengths and weaknesses already provided. Rather, he/she should identify major issues with which he/she disagrees and raise additional issues that he/she feels should influence the score of the application. RGP committee members have access to research applications and are expected to familiarize themselves with each application prior to review meetings. RGP committee members are expected to listen carefully to each presentation and be prepared to defend or change their point of view based on the scientific arguments. All members of the RGP committee are encouraged to keep an open mind, but not to yield merely to reach consensus. Committee members should not hesitate to express their views, but should avoid statements that might be considered offensive. Consensus is not a necessity; the committee Chair will determine when further discussion is not likely to resolve scientific differences of opinion. After discussion, RGP members will assign priority scores to the application. Reviewers are encouraged to modify their written critique so that the written summary statement reflects the overall evaluation of the application. Resubmitted Applications: Critiques should include an evaluation of the changes made in response to the last review. Investigator’s response to previous criticisms, however, is only one component in the overall evaluation of the resubmitted application. Reviewers can also raise new criticisms and/or disagree with previous comments on strengths and weaknesses of the proposal. March, 2012 15 Conflict of Interest The RGP chair and staff will identify conflicts of interest involving investigators and reviewers. The following are considered potential conflicts: Investigators with whom the reviewer/RGP committee member has a financial and/or professional relationship. The funding decision on any application would benefit the reviewer directly. The reviewer feels there may be a perception of conflict. Critiques may be obtained from individuals outside the standing membership of RGP committee at the discretion of the RGP Chair. Confidentiality Applications are considered confidential, and respect for the privacy of investigator ideas is to be maintained. Misappropriation of intellectual property, including the unauthorized use of ideas or unique methods obtained from a privileged communication such as a grant or manuscript review, is considered plagiarism and falls under the definition of scientific misconduct. Likewise, peer review is enhanced by the confidentiality provided to reviewers and RGP committee members. The RGP committee roster is available on request to the RGP Chair and staff. Investigators are encouraged to discuss written critiques and their priority score with the RGP Chair. Committee Members Responsibilities Review applications and write critiques in a timely and constructive manner. Attend committee meetings on a regular basis. The RGP Chair may remove a committee member who is: Absent from two consecutive committee meetings, unless the absences are unavoidable because of scheduling conflicts. Unable to review applications and write reviews in a timely and constructive manner. Investigator Responsibilities (Post Award) Release of funds must occur within 90 days of funding approval. RGP progress reports are required annually and are due 60 days prior to the grant anniversary date. Critical review of the progress report will determine continuing project support. Reports must follow RGP progress report guidelines. IACUC, IBC, and/or IRB ongoing review submissions will not be accepted in lieu of the RGP report. Initial and ongoing financial support must be linked to the project aims/timelines established in the application. Projects must be completed within two years of initial funding. Research Advancement and Vision Award investigators may request an additional 6 months for data analysis and manuscript preparation. RGP final reports are due within 90 days of project completion or study closure, whichever occurs first. The final report must include a list of manuscripts, presentations and grant proposals resulting from funding. Reports must follow RGP final report guidelines. Data generated through grant support should be archived and made available to other Scott & White investigators. Each publication, press release, or other document that cites results from RGP-supported research must include an acknowledgment of RGP support and disclaimer such as “The project described was supported by the Scott and White Research Grants Program (RGP).” March, 2012 16 BUDGET GUIDELINES The following budget guidelines apply to ALL Scott & White Research Grants Program Awards: Allowable expenses include: 1. Research supplies and animal maintenance 2. Salary for Clinical Research Coordinators, and stipends for graduate students and postdoctoral assistants if their role is to promote and sustain the project 3. Equipment costing less than $5,000 (equipment costing over $5,000 requires cost-sharing with the Department) 4. Investigator’s salary consistent with the percent effort justified by the proposed research 5. Patient stipends 6. Technical assistance 7. Publication costs, including reprints 8. Special fees (pathology, photography, etc.) The following expenditures are NOT permitted: 1. Secretarial/administrative personnel 2. Tuition 3. Travel to scientific meetings 4. Honoraria and travel expenses for visiting lecturers 5. Per diem charges for hospital beds 6. Construction and building maintenance 7. Major alterations 8. Purchasing and binding of periodicals and books 9. Office and laboratory furniture 10. Office equipment and supplies 11. Rental of office and laboratory space 12. Recruiting and relocation expenses 13. Scientific society dues and membership fees Indirect costs are not applicable to these awards. March, 2012 17 Letter of Intent Advancement and Vision Award applicants MUST submit a Letter of Intent, no later than 30 days prior to submission deadline, to Jessica Rostockyj, Research Grants Coordinator, at [email protected] . A sample format for the letter is provided below: Date Jessica Rostockyj Research Grants Coordinator, Research Grants Program Scott & White Healthcare 2401 South 31st Street Temple, TX 76508 RE: Intent to submit application Ms. Rostockyj: This letter is to inform you that I plan to submit a <insert Research Advancement Award or Research Vision Award> application for the <insert deadline date> deadline of the S&W Research Grants Program. The tentative title of the proposed study is <insert title>. This is a <insert human, animal, or bench> study. The study involves <insert a short description of the project>. I understand that I will be contacted by a member of the RGP staff who will assist me with the application process. This will include a review with feedback of the application’s proposed budget. Please let me know if you have any questions. Sincerely, <PI Signature> <PI Name <PI Title> March, 2012 18 Technical Support Scott & White Research Grants Program Jessica Rostockyj Research Grants Coordinator 771-4842 or [email protected] Office of Scientific Investigator Development Sandhya Sanghi, PhD, MPH Research Proposal Development Specialist 771-4831 or [email protected] Biostatistics (Contact Holly Hall @ 771-4820 or Hhall @swmail.sw.org for appointments) Juhee Song, PhD Senior Biostatistician 771-4853 or [email protected] Chanhee Jo, PhD Biostatistician 771-4854 or [email protected] Research Feasibility Teresa Ponder Feasibility Analyst 771-4864 or [email protected] Research Finance Jared Brock Financial Analyst 215-9053 or [email protected] Clinical Research Coordination Lydia Clipper, RN 724-8193 or [email protected] Publications Glen Cryer Manager 771-4807 or [email protected] March, 2012 19
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