EBV é igualmente encontrado no tecido tumoral do carcinoma ductal invasivo e na forma
lobular invasiva do câncer de mama.
Epstein-Barr virus infection is equally distributed across the
invasive ductal and invasive lobular forms of breast cancer.
Ballard AJ1.
Pathol Res Pract. 2015 Dec;211(12):1003-5. doi: 10.1016/j.prp.2015.09.017. Epub 2015 Sep
25.
Author information
1
Department of Cellular Pathology, The Royal Bournemouth Hospital, The Royal
Bournemouth and Christchurch Hospitals NHS Foundation Trust, Castle Lane East,
Bournemouth, Dorset, United Kingdom. Electronic address:
[email protected].
Abstract
The role of Epstein-Barr virus (EBV) in the pathogenesis of breast cancer is still unclear,
although a growing body of evidence supports a link. The aim of this study was to investigate
if EBV infection was more prevalent in invasive ductal carcinoma or invasive lobular
carcinoma. An immunohistochemical marker for EBV (Epstein-Barr virus nuclear antigen 1
(EBNA1) clone E1-2.5) was applied to a tissue micro array section. The tissue micro array
contained 80 cases of invasive ductal carcinoma, and 80 cases of invasive lobular
carcinoma. Each case was scored as positive or negative for nuclear expression of EBNA1 in
tumor cells using standard light microscopy. EBNA1 staining was evident in the tumor cells of
63 cases (39.4% of tumor cases). By tumor type (ductal/lobular) EBV infection was noted in
34 (42.5%) cases of invasive ductal carcinoma and 29 (36.2%) cases of invasive lobular
carcinoma, this difference was not found to be significant (P=0.518). This study indicates that
EBV infection is equally distributed across the ductal and lobular tumor types.
Copyright © 2015 Elsevier GmbH. All rights reserved.
KEYWORDS:
Breast cancer; Epstein–Barr virus; Invasive ductal carcinoma; Invasive lobular carcinoma
PMID:
26481274