THE UNIVERSITY
OF HONG KONG
DEPARTMENT OF MECHANICAL ENGINEERING
D E P A R T M E N T O F M E CAHNADN I C A L E N G I N E E R I N G
MEDICAL ENGINEERING PROGRAMME
SEMINAR
SEMINAR
Title:
Cellular subcompartments through cytoplasmic streaming
Speaker:
Dr. Gregory Jedd
Temasek Life Sciences Laboratory &
Department of Biological Sciences
1 Research Link
The National University of Singapore, Singapore
Date:
28 July, 2016 (Thursday)
Time:
11:15 a.m.
Venue:
CBLG1-09, Composite Building, HKU
Abstract:
Cytoplasmic streaming occurs in diverse cell types, where it generally
serves a transport function. This talk will focus on work defining an
additional function wherein streaming leads to the formation of distinct
cytoplasmic subcompartments. In fungal hyphae, cytoplasm flows
directionally from cell to cell through septal pores. Live-cell imaging and
computer simulations identify a flow pattern that produces vortices on the
upstream side of the septum. Nuclei can be immobilised in these
microfluidic eddies, where they form multinucleate aggregates and
accumulate foci of the HDA-2 histone deacetylase-associated factor, SPA19. Pores experiencing flow degenerate in the absence of SPA-19,
suggesting that eddy-trapped nuclei function to reinforce the flowstressed septum. Together, these data show that cytoplasmic
subcompartments can be self-organized as a consequence of regimented
cytoplasmic streaming.
Bio:
Gregory Jedd earned his bachelors degree in biology at Stanford University.
He received his PhD from the University of Chicago and did his
postdoctoral work at the Rockefeller University where he began to use the
filamentous fungus Neurospora crassa to investigate fundamental
questions in cell, developmental and evolutionary biology. In 2004 he
moved to Singapore to establish an independent research group at the
Temasek Life Sciences Laboratory (TLL) where he is currently a senior
principal investigator.
ALL INTERESTED ARE WELCOME.
For further information, please contact Dr. A. Shum at 3917 7904.
Research area: Biomedical Engineering