Running Head: TRANSPERSONAL PERSPECTIVE OF PLACEBO EFFECT Explanation of the Placebo Effect from a Transpersonal Psychology Perspective Leah B. Mitchell Western New Mexico University 1 TRANSPERSONAL PERSPECTIVE OF PLACEBO EFFECT 2 Abstract This paper briefly explores the field of transpersonal psychology, its history, and provides a summary of several peer reviewed studies results that explain the placebo effect from a transpersonal psychology perspective. It also illustrates the importance of the placebo effect’s future use in human health and wellness. Transpersonal psychology is a branch of psychology that strives to incorporate the scientific side of psychology with the metaphysical – such as transcendent experiences and altered states of consciousness – to make possible the exploration and research of unexplainable phenomena, and fully understand the human mind and experiences. Research has shown that not only can the placebo effect be reproduced, but that it is often attributed to personal beliefs and intention, and has a positive impact on the health and wellness of those experiencing it. Even though the placebo effect’s underlying mechanisms in action cannot completely be explained, and it cannot be touched or easily quantified, it is a very real phenomenon that should be thoroughly studied and explored. The following studies illustrate that the best mechanisms for its exploration lie within the boundaries of transpersonal psychology and its holistic perspective on health and well-being. The implications suggested by these studies are of no little significance to humanity and should therefore undergo further indepth research for the benefit of all. Keywords: transpersonal psychology, placebo effect, holistic, biofield TRANSPERSONAL PERSPECTIVE OF PLACEBO EFFECT 3 Explanation of the Placebo Effect from a Transpersonal Psychology Perspective Transpersonal psychology is a sub-field of psychology that attempts to integrate the science of psychology with the insights of various spiritual disciplines –including the role of altered states, mystical experiences, contemplative practices, and ritual for self-healing and transcendence. It is a holistic approach to an individual’s health addressing the needs not only of their body and mind, but of their spirit as well, that combines knowledge and observation of “exceptional human experiences of healing into the everyday practice of medicine, and to make extraordinary healings ordinary” (Fauver, 2014). Practiced with a transpersonal perspective approach, mind and body healing takes on a whole new level of possibilities and applications. For example, the placebo effect is when a placebo – a substance with no known medical effects – is given to a person who then experiences a health or medical improvement, as if they had taken actual medicine. The amount of statistical evidence supporting the existence of the placebo effect phenomenon and the implications for its beneficial use in healing is staggering. According to Price, Finniss, and Benedetti (2008), the research community’s perception and approach to understanding this effect has altered its focus from a placebo simply being an inactive medicinal treatment, to a comprehensive reproduction of curative treatment. It has been found that many placebo responses are caused by various means that are dependent upon context. For example, analgesic placebo responses have been known to be triggered and sustained simply by a patient’s expectation of lessened symptoms, as well as emotional or motivational shifts. It has been known for many years that the placebo effect has shown to produce physiological changes in patients; it is not just response bias. According to the researcher (as sited in de Craen et al., 1999) who conducted what is now believed to be the first controlled trial of the placebo effect in 1799, “[A]n important lesson in physic is here to be TRANSPERSONAL PERSPECTIVE OF PLACEBO EFFECT 4 learnt, the wonderful and powerful influence of the passions of the mind upon the state and disorder of the body” (Price, et al., 2008). A few hundred years later with more in-depth research and better technology, we are finally beginning to explore in earnest the holistic aspect of human beings by acknowledging the possibility of a mind-body-spirit system, and becoming more able to identify both psychological and neurobiological components that make the placebo effect possible. In this review of placebo effect statistics, one way that is used to study placebo effect is the open-hidden paradigm, which refers to the ways in which a patient can receive treatment; open treatment is performed by a clinician in full view of the individual, and hidden treatment is received in an impersonal manner, where the individual is not necessarily aware they are receiving treatment or not, such as via an IV drip (Price, et al., 2008). During several studies conducted (as cited in Amanzio et al. 2001, Benedetti et al. 2003, Colloca et al. 2004, Levine & Gordon 1984) it was revealed that open treatment is notably more effective than hidden treatment. One study was conducted in which the treatment was given openly by a physician who also offered verbal support and suggestions for relief of the patient’s pain. These patients experienced greater pain reduction than the group of patients whose medicine was administered impersonally via concealed mechanism. Following the same openhidden model, another study revealed that patients receiving the open style treatment required less pain medication post-surgery than did those who received hidden treatment. It has been known for many years now that during the use of analgesic placebo treatment, the individual patient responses vary from profound to inconsequential, though what is not known is why. Perhaps the inconsistency is due to an undiscovered and currently immeasurable influence. After all, different patients will be affected differently by various environmental, emotional, and cognitive factors including memory, expectancy, and desire. Those factors, in turn, will affect the TRANSPERSONAL PERSPECTIVE OF PLACEBO EFFECT 5 many components of placebo response, such as its quality, extent, and overall significance (Price, et al., 2008). According to this review, the emotional and cognitive effects on the placebo effect involve expectancy, memory of previous experience, and desire. The study defines expectancy as the likelihood a patient will experience an expected outcome, and memory of prior experiences can also play a role in the outcome of a treatment. Also of significance is the desire of the patient to reduce their physical pain and or discomfort, or their desire to increase the occurrence of positive feelings or abilities. In analgesic placebo studies, it is thought that desire and expectancy combined can have profound effects on treatment results (Price et al., 2008). There is much research that illustrates that when studied from a transpersonal perspective, the placebo effect has an enormous potential to be used to benefit clinical research as well as to promote and encourage healing. More recent laboratory and applied research has already attempted to explain the placebo effect from a transpersonal psychology perspective, with promising results. It is becoming clear that even as science and technology advance, humanity is experiencing a somewhat spiritual paradigm shift, and the fields of transpersonal psychology and transpersonal healing/medicine are becoming increasingly more relevant and necessary by the day. Literature Review The two schools of psychology in America that monopolized the field in the mid 1900’s were Freudian psychology and behaviorism. Out of frustration of the inadequacy of these two schools of thought to completely explain the human psyche, humanistic psychology was developed and pioneered by psychologists such as Carl Jung, Abraham Maslow, and Anthony TRANSPERSONAL PERSPECTIVE OF PLACEBO EFFECT 6 Sutich, who disagreed with the heavy reliance on abnormal pathology and Freudian psychoanalysis to explain away all of humanity’s psychological processes. In contrast, humanistic psychology focused more on “human growth and potential, and on higher functions of the psyche” and “emphasized that psychology has to be sensitive to practical human needs and serve important interests and objectives of human society” (Grof, 2008). To Maslow and Sutich, however, humanistic psychology’s broad range of approaches concerning interpersonal, psychosocial, psychosomatic, and emotional problems was still missing a vital aspect – the human psyche’s spiritual element. The social culture of the time, with its new interest in Eastern metaphysical practices as well as its increasingly popular experimentation with psychedelic drugs and altered states of consciousness, suggested to them that a more comprehensive psychological school was needed that would include aspects of consciousness, psychedelic and trance states, creativity, science, and religion. It was then that a truly holistic approach, emphasizing the importance of the whole and the interdependence of its parts, to the human psyche was developed: transpersonal psychology. Prior to the development of the transpersonal approach, modern Western psychology had been described by Michael Harner, an American anthropologist, as ethnocentric because it had been “formulated and promoted by Western materialistic scientists, who consider their own perspective to be superior to that of any other human groups at any time of history” (Grof, 2008). These scientists believed that matter was the whole of it, intelligence and consciousness were unimportant byproducts, and that spirituality of any kind suggested ignorance, superstition, and primitive thinking. It is not a surprise that transpersonal psychology was conceptualized; it was done out of necessity to meet deeper physical and psychological needs that were not previously being met. TRANSPERSONAL PERSPECTIVE OF PLACEBO EFFECT 7 Transpersonal psychology picked up where humanistic psychology fell short, much in the way that complementary and alternative medicine is bridging gaps left by standard Western medical practices. Its holistic approach to health and wellness of the mind, body, and spirit, and its perspectives on relatively unexplained phenomena such as the placebo effect, can potentially benefit humanity in ways that would have been unthinkable a mere fifty years ago. The placebo effect, while proven to be a real phenomenon, is commonly overlooked as a viable means to healing and/or recovery. However, by looking at it from the perspective of transpersonal psychology we can begin to understand its possible mechanisms and begin to utilize it fully. Further, since it has been demonstrated time and again that our thoughts and intentions can positively or negatively affect our physical health, by not approaching our health in a holistic manner we are not taking full advantage of our self-healing capabilities. A study by Brook and Fauver (2014) suggests that the placebo effect is the same as what they refer to as “therapeutic ritual healing”, which is defined as the healing from an injury or illness because of some type of therapeutic ritual between the patient and physician. They hypothesize that it is the human biofield, which uses electromagnetic frequencies to relay messages to other parts of our bodies internally, to and from each other and our environments, that makes the placebo effect possible. The term “biofield” refers to an electromagnetic field that surrounds and penetrates all living organisms. It occupies the space around our bodies externally, and our organs, and even cells, internally. This study states that the biofield’s “informationladen, wave-oriented, transference of energy appears to be capable of carrying messages of healing, and its capacity to give instructions to damaged organs and cells appears to be instantaneous”, as well as that the biofield seems to be finely receptive to both cognitive and emotional states, and able to be influenced “by others through the therapeutic relationship” TRANSPERSONAL PERSPECTIVE OF PLACEBO EFFECT 8 (Brook & Fauver, 2014). This study concludes that because the biofield is responsive to thoughts and suggestions, therapeutic ritual healing can indeed have a positive impact on the human biofield and aid in healing. According to a study review by James Giordano (2016), there has been ample research done that shows there is a physiological mechanism for the placebo effect, and that is can have a positive benefit on the treatment and health of the individual patient. He suggests that using the placebo effect as a treatment should be permitted if the patient has asked for treatment, there is an established and trusting doctor/patient relationship, traditional treatment has not been effective and/or it does not interfere with traditional treatment, and the cost is no more than the doctor’s basic office visit fees. Of course, to green-light the use of placebo effect for patient treatment, ongoing research will be necessary in determining when placebo treatment works or does not work, which patients it will work on and when, and under what conditions, as well as the ethical complications or restraints that accompany this type of treatment (Giordano, 2016). Studies on the neurobiological aspect of the placebo effect by Meissner, Bingel, Colloca, Wager, Watson, & Flaten (2011) focused on whether placebo treatments exert any influence on the “pain processing network”, which is the region of the brain that is associated with the experience of pain. The research studies concluded that “placebo analgesia involves the activation of cingulo-frontal brain regions together with subcortical structures such as the midbrain periaqueductal gray (PAG), hypothalamus, and amygdala. Connectivity analyses further revealed that the behavioral placebo analgesic effect depends on an enhanced functional coupling of the rACC with brainstem areas such as the PAG” (Meissner, et al, 2011). What that translates to is that the authors of the study determined that the placebo effect is an authentic and measurable neurobiological experience that has substantial possible benefits to both health care, TRANSPERSONAL PERSPECTIVE OF PLACEBO EFFECT 9 and clinical research, and suggest further investigation should be carried out because of its importance to future health care treatment. Another study done by Kelly A. Turner at the University of California, Berkeley (2014), focused on surveying twenty patients who experienced spontaneous or radical remission of cancer – which the study defined as “a remission that occurs without medical treatment, or with medical treatment considered inadequate to produce the remission” – and fifty “nonconventional healers” from eleven different countries. The physicians answered questions related to what they thought caused cancer, and the RR patients were questioned on why they thought they were cured. The results of the survey showed that among all seventy of the subjects interviewed, there were three prominent beliefs that occurred. The first underlying belief was that a mind-body-spirit interaction exists. The second, that cancer cells only thrive under adverse conditions in the mind-body-spirit system and that to kill the cancer a patient must change the adverse conditions into positive conditions. Finally, the third was that illnesses represent a blockage in our mind-body-spirit system, and health represents flowing movement. The study also showed that the belief that we have a mind-body-spirit system has three sub-beliefs: that thoughts and energy affect our physical selves; that the spirit is our primary aspect of being, not mind-body; and that energy is in everything (Turner, 2014). The study strongly suggests that the results of placebo research, psychoneuroimmunology, and epigenetics provide substantial evidence for the sub-belief that thoughts can affect the physical body. In a final study Haimerl & Valentine (2001) questioned whether practicing Buddhist meditation would lead to positive development on all three levels, self-directedness, cooperativeness, and self-transcendence, which represent the intrapersonal, interpersonal, and transpersonal levels of self-concept. They predicted it would, and distributed a questionnaire TRANSPERSONAL PERSPECTIVE OF PLACEBO EFFECT 10 consisting of 102 questions sampled from three sub-scales of the Temperament and Character Inventory (TCI): 38 intrapersonal, 38 interpersonal, and 26 transpersonal. Upon conclusion of the study, their prediction proved accurate and they discovered that “the greatest changes as a function of meditation experience were on the transpersonal scale” (Haimerl & Valentine, 2001). Discussion Limitations As with any alternative healing method, the use of the placebo effect in health care does have some limitations and complications. In an assessment of laboratory and clinical trials regarding transpersonal healing, a common and popular form called distant healing intention (DHI), was discussed. Marilyn Schlitz determined that despite the popularity of DHI, its efficiency rate was sporadic and the mechanism for the healing that did occur was not clear. In her conclusion, however, Schlitz suggested that even with the results not being indisputable, there was enough evidence to show both ontological and epistemological significance of its possible use, and ways in which science and spirituality can be combined (Schlitz, 2014). Similarly, Brook and Fauver’s study, while promising, is limited due to an inability to physically measure and ascertain the existence of a “biofield” that can explain the emotional, mental, physical, and spiritual treatments on an individual (Brook & Fauver, 2014). One could make a convincing argument that it is possible the findings of Marilyn Schlitz lend support to Brook and Fauver’s theory of a physical biofield – with the implication that the closer physical biofields are to each other, the greater the possibility of electron exchange. The findings could also suggest a transpersonal/placebo relation to Lev Vygotsky’s social theory, the “zone of proximal development (ZPD). If human beings can learn more efficiently when in close TRANSPERSONAL PERSPECTIVE OF PLACEBO EFFECT 11 proximity to others, perhaps we can also heal ourselves more effectively in close proximity to others who support our therapeutic efforts. The idea makes even more sense when considering that Vygotsky himself went through somewhat of a “holistic period”. In 1925, he wrote a paper titled Consciousness as a Problem in the Psychology of Behavior, in which he discusses the lack of integration of consciousness and psychology and suggests that because of that, the field of psychology is limiting itself from seeing the whole picture (Vygotsky, 1979). Unfortunately, much of his work during that period was fragmented and unpublished until many years later. Giordano (2016) suggests, citing a more complex issue, that the major limitations of the placebo effect involve ethics. While a patient can benefit somewhat from a placebo that they are aware of, it has been shown that to receive the full benefits the patient should not be aware that they are being given a placebo treatment. Whether it is ethical to essentially lie to a patient – even if for the patient’s own benefit – or not, is something that is, and will continue to be, difficult to determine. Another limitation, pointed out by Gabriel S. Crane of the California Institute of Integral Studies, suggested that an “obvious and critical” limitation concerns with “retaining a respect and appreciation for both the placebo effects and the evidence-based treatments that good, reputable science demonstrates”, and believes that there is not just one placebo effect, but many, which will all benefit or effect individuals differently (Crane, 2016). Finally, a limitation with some importance regarding the discussion and implementation of placebo healing is the significant divide between new-age metaphysics and religion and the strictly mechanical application of science, in which anything that cannot be easily explained by hard science is simply dismissed as insignificant (Ferrer, 2016). Because of this divide, perhaps the biggest limitation of all are those who refuse to acknowledge the potential benefits of placebo TRANSPERSONAL PERSPECTIVE OF PLACEBO EFFECT 12 use, and who dismiss the findings of legitimate studies as being insignificant only because they cannot be easily explained by our current scientific standards. Conclusion and Future Study Glenn Hartelius from the California Institute of Integral Studies (2016) reviewed the history of two approaches to transpersonal psychology: the perennialist and the participatory. The perennnialist approach suggests that different ideas about the nature of reality are simply flawed impressions of a primary, nondual source. This source exists in and of itself without relying on, referring or relating to, anything else –a smile is always a smile, no matter who it belongs to or why it appears. However, in the participatory approach, existence is relational to all else. With this approach, a smile is something that occurs in relation to something else, such as an emotion or an occurrence. Therefore, an individual may be smiling at something someone said, but is simultaneously living in a world where other people also smile, for a vast amount of reasons. Hartelius suggests that if transpersonal experiences are viewed as a product of relationships, our extraordinary experiences become real events that can be scientifically studied, rather than mystical phenomena. Consequently, the field can research topics such as supernormal abilities, intuition, distance healing, etc. while still being taken seriously by the scientific community and academia (Hartelius, 2016). It is true, as Fauver suggests (2016), that “changing to a new medical paradigm will not be easy”; he believes that there are three stages that must be experienced before a paradigm shift in thinking can occur. First, our society must recognize that there is an anomaly. The placebo effect, among many others, is one such anomaly, in that it does not fit in with the modern model of medicine. Second, most of society must gradually realize that there are inconsistencies. I TRANSPERSONAL PERSPECTIVE OF PLACEBO EFFECT 13 believe we are beginning to realize that now. Finally, society will shift over to the new paradigm, even though there will still be resistance for a while (Fauver, 2014). The placebo effect, when viewed in a transpersonal context, is a phenomenon that can potentially benefit the health of the entire human species. It is widely recognized that the placebo effect, as well as transpersonal psychology and alternative healing, are subjects on which more thorough and intensive scientific research is necessary. Of course, while scientific methods and studies should be utilized, the focus of transpersonal studies should not be limited to science, nor turned into a strictly scientific field; that may not even be possible. If that happened, its growth and potential would be hindered by trapping it in a single, closed worldview. Both transpersonal psychology and the placebo effect, need to be allowed to be researched and practiced holistically and with open-mindedness (Ferrer, 2014). A paradigm shift is indeed taking place in both psychology and medicine; we must simply continue the groundbreaking work and research until the balance tips in favor of the health and well-being of the many aspects of humanity. TRANSPERSONAL PERSPECTIVE OF PLACEBO EFFECT 14 References Brook, M. G., & Fauver, R. (2014). A possible mechanism of action for the placebo response: human biofield activation via therapeutic ritual. International Journal of Transpersonal Studies, 33(1), 131–147; http://dx.doi.org/10.1016/j.imr.2015.04.093 Crane, G. (2016). Crane, G. (2016). Harnessing the placebo effect: A new model for mind-body healing mechanisms. International Journal of Transpersonal Studies, 35(1), 39-51; http://digitalcommons.ciis.edu/ijts-transpersonalstudies/vol35/iss1/6 Fauver, R. (2014). Introduction to special topic section: Toward a transpersonal medicine. 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