A
COs
NCOs
all events
0.6
0.5
Interference
0.4
0.3
0.2
0.1
0
-0.1
-0.2
wt
tel1∆
sgs1∆
zip3∆
msh4∆
zip3∆
tel1∆
-0.3
B
zip3∆
sgs1∆
Interference
1.2
1.0
Detectable COs
Detectable NCOs
All detectable products
DSBs
0.8
0.6
Simulated strength of DSB interference along the
bundle of four chromatids, each pair of sisters, or
each chromatid, as indicated
0.4
0.2
0
DSB interference
extends across:
C
Each pair of
sisters
D
15
10
5
0
0
500
1000
1500
local DSB frequency
(reads per million)
Four-chromatid events in data
randomized with DSB
landscape
3.0
wt
tel1∆
20
Each
chromatid
% of recombination
events
% of recombination
events
All four
chromatids
Complex events in data
randomized with DSB
landscape
25
Strength of interference
measured across all four
chromatids
2000
wt
tel1∆
2.5
2.0
1.5
1.0
0.5
0
0
500
1000
1500
local DSB frequency
(reads per million)
2000