K
SEBOLYTIC® SHAMPOO
PROPERTIES:
APPLICATIONS:
• Antiseborrheic
Cleansing shampoo as an aid for the control of
keratoseborrheic disorders in dogs and cats
• Keratolytic
• Keratomodulating
• Antibacterial
• Antifungal
What goes wrong in keratoseborrheic disorders (KSD)?
S h a m p o o
Staphylococcus
intermedius
HYPERSEBORRHEA
Alteration in sebum
and epidermal lipids
secretion / composition
Malassezia
pachydermatis
MICROBIAL
PROLIFERATION
KERATINIZATION DEFECTS
Abnormal
differentiation
Epidermal barrier
deficiency
Excessive scale formation
= Hyperkeratosis
INFLAMMATION AND PRURITUS
Basal cells
hyperproliferation
Inflammatory infiltrate
Neutrophils
6/17
Lymphocytes
Mastocytes
MALODOR
Sebolytic® response: a multi-site action
TARGET ACTIONS
Remove
excess
scale
ACTIVE
INGREDIENTS
Salicylic acid
Exfoliant action
Keratoplastic effects on the
intercellular cement
(15)
(15)
Mildly bacteriostatic
Linoleic acid
Decrease horny layer thickness
Help to control bacterial
proliferation
(15)
Incorporation in the intercellular cement
(16)
Restore the epidermal barrier
Maintain functional integrity of
keratinocytes and promote their
normal maturation
‫ ﻻ‬linolenic acid
Major structural component of cell
membrane phospholipids (17)
Zinc gluconate
Inhibits the enzyme 5α reductase which
Reduce sebum secretion
stimulates sebaceous secretion (18)
2. Regulate sebum production
Vitamin B6
Piroctone olamine
Synergistic inhibition of 5α reductase
(18)
Large antimicrobial spectrum (3, 4)
(Gram + & Gram – bacteria, yeasts)
High affinity for keratines
3. Control microbial proliferation
Glycotechnologies
4. Reduction of skin inflammation
Tea tree oil
Reduce sebum secretion
Antimicrobial activity
High persistence on skin and
hairs
(3)
Microbial anti-adhesive effect
5. Control malodor
BENEFITS
Solubilises intercellular cement
1. Correct keratinisation defects
Regulate
the keratinisation
process
PROPERTIES
(5-9)
Antimicrobial activity
Natural sugars present in epidermal cell
Respect the skin / microflora
membranes (10)
Reduction of cytokine signalling (11, 12)
Immunomodulatory properties
reduction of inflammation
Natural pleasant odor
Reduce malodor
Interact with microbe membranes
Reduction of histamine and
inflammatory mediators production
7/17
(20)
(21)
Antimicrobial activity
Reduction of skin inflammation
and itching
An optimised formula
A formulation for optimal tolerance
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Mild cleansing agents
Physiological pH.
No coal tar, therefore :
o No skin irritating, drying and staining effect
o No unpleasant shampoo odor, appearance and color
o Can be used in cats
Tea Tree Oil provides a natural pleasant herbal scent, therefore no perfume was added to the shampoo, reducing
hypersensitization hazards.
Glycotechnologies complement the antimicrobial activity of piroctone olamine while respecting the cutaneous ecosystem
A formulation for deep targeted action in skin
To exert their inhibitory action on sebaceous gland secretion, topical zinc and vitamin B6 should penetrate and diffuse
into deep skin structures. For this purpose they were incorporated, together with monosaccharides, in Non-ionic
Spherulites®, that favour the flow of active ingredients to their sites of action. (22)
Zinc gluconate
Vitamin B6
Sebaceous
glands
Hair
follicle
Non-ionic Spherulites® delivering zinc gluconate and vitamin B6 in deep cutaneous structures
What are the proofs of Sebolytic® efficacy and safety?
Sebolytic® safety in cats
Tolerance study to evaluate shampoo safety in cats (23)
A number of reports have described signs of toxicity associated with the use of highly concentrated, low quality Tea Tree oil
(Melaleuca oil) products in cats. However, an adapted much lower concentration (0.25%) of Melaleuca oil in the new Sebolytic
shampoo, and the high quality of the raw material used, prevent the occurrence of similar hazards in cats. A specific study was
performed to confirm the good local and general tolerance of the shampoo in this species.
RESULTS:
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No significant change in animal body weight or food consumption was recorded over the study period.
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No local or general intolerance signs to the test shampoo were recorded. In particular, no skin irritation could be
detected at any of the examination time points.
8/17
Sebolytic® clinical efficacy in dogs with KSD
Randomized, double blind, multi-center field trial to evaluate clinical and antimicrobial efficacy of tar and non-tar
antiseborrheic shampoos for dogs. (24)
•
•
•
•
INCLUSION
CRITERIA
Dogs with severe/greasy KSD
No pyoderma, parasitic disease, flea allergy dermatitis
No treatment in the previous 3 weeks
No concomitant treatment
Sebolytic
with tar
23 dogs
47 dogs
7 baths 3 day-intervals
Day 1
B L I N D
E V A L U A T I O N
1
2
Scales
Skin greasiness
Skin malodor
Overall skin & haircoat condition
Associated signs:
pruritus, erythema, excoriations
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Product
- smell
- color
- consistency
- ease of use
Cocci, Malassezia counts
(oil immersion objective)
MICROBIAL SCORE (0 to 4)
2
KSD Index reduction after 20 days of treatment
16
3
Scotch test & cytological exam
at skin target sites:
KSD INDEX (0 to 16)
1
USER SATISFACTION (0 to 4)
Relative reduction of microbial score on treatment
Day 1
Malassezia
14
12
Day 1
10
8
Day 20
4
22.2
Sebolytic with tar
4.2
Sebolytic without tar
2
100
Before treatment
16.7
Sebolytic with tar
Day 20
Cocci
6
D20
24 dogs
Sebolytic without tar
5.6
Sebolytic without tar
100
Before treatment
0
Sebolytic without tar
0
Sebolytic with tar
3
Product appreciation by users
ODOR
Very satisfied
APPEARANCE & COLOR
Satisfied
Unsatisfied
SEBOLYTIC WITHOUT TAR
0%
SEBOLYTIC WITH TAR
20%
SEBOLYTIC WITHOUT TAR
40%
SEBOLYTIC WITH TAR
60%
SEBOLYTIC WITHOUT TAR
80%
SEBOLYTIC WITH TAR
100%
GENERAL APPRECIATION
Not satisfied at all
9/17
20
40
60
80
100
Sebolytic® without tar proved as
effective as the reference tar
shampoo, in controlling severe
KSD signs and associated
microbial proliferation in dogs.
This new antiseborrheic shampoo
represents a safe, better-accepted
and efficient topical treatment
alternative to coal-tar products in
veterinary dermatology.