1 ® W ho We Are Learn how we became an industry leader Our Mission Our Growth Story At PhysioAge Medical Group, we believe that the goal of health care ought to be exactly that—care of your health, not only prevention and treatment of disease. Our mission, therefore, is to provide the most advanced, scientifically-validated diagnostics and therapeutics available to help women and men feel and look as healthy as possible as they grow older. Our Vision We will be the leading national network of age management physicians with a focus on quality clinical patient management. Rather than be the biggest, we’ll be the best. Our target market is decidedly upscale and willing to pay more for the PhysioAge brand. We will leverage our clinical and operational experience to ensure every Partner meets or exceeds the highest standards of excellence. Our Approach Our approach to HRT can best be described as “Precision Medicine”: each patient deserves a comprehensive evaluation and an individually-tailored treatment regimen that must be continually optimized. We don’t subscribe to the “one size fits all” philosophy followed by most physicians when treating hormonal imbalance. Every patient is different and everybody responds differently to the same dosage. We believe the path to optimized health consists of balanced bioidentical hormone replacement, anti-oxidant therapy and proper nutrition & exercise. Our next-generation physical exam is able to detect preclinical disease states and measure an individual’s rate of aging. Every patient gets a comprehensive assessment of the health of each major physiological system—the PhysioAge Composite—and then a tailored program of exercise, diet, nutritional supplements, and bioidentical hormone replacement therapy to slow, and in some cases, reverse the decline in their physiological age. 2 Our History Our dream - 1994 As primary care internists at Dartmouth Hitchcock Clinic in New Hampshire, we were growing increasingly frustrated treating sickness instead of preventing it. We wanted to escape the insurance maze and be free to practice medicine in the best interest of the patient, not how the insurance company dictates. Our opportunity - 1995 Shortly after HGH was approved for the treatment of AGHD, we started conducting research in a new field called Anti-Aging Medicine. We quickly developed an intense passion for the field and became diplomats of the American Academy of Anti-Aging Medicine. We developed our own scientifically-based treatment programs after thoroughly researching all of the available literature. Making it happen - 1997 Once we realized this was the future of medicine, we left our clinic in NH and moved to NYC to start our own upscale practice on Central Park South – the first of its kind on the East Coast. PhysioAge Medical Group opened its doors in 1997 with a handful of patients and one employee. We started using our gold-standard clinical protocols in practice and began the long process of perfecting them. The first few years were very slow. Realizing our dream - 2002 Jerry Fortunato joined the practice and put into place a comprehensive marketing program that resulted in a rapid expansion of the patient base from 200 to 800 patients. To accommodate this rapid growth, Jerry developed a customized technology infrastructure and proprietary workflows, policies and procedures to manage quality. Building upon our success - 2009+ Today we are one of the most successful age manage ment practices in the nation, with 6 locations nationwide and counting. We have tested and refined our gold-standard clinical protocols on more than 2,200 patients. We leverage our experience to help other physicians achieve the same level of success, without the learning curve. CBS Evening News interview with Dr. Ron Livesey Our Principals Ronald V. Livesey, MD Dr. Livesey received his MD in 1972 from Tufts University School of Medicine, completed his residency at St. Elizabeth’s Hospital/Boston, and was a member of the clinical faculty at Tufts Medical School. Dr. Livesey has been featured in The CBS Evening News, The New York Times, USA Today, Elle, and the 2002 Award Winning BBC Documentary: How To Build A Human: Part IV: Forever Young. Joseph M. Raffaele, MD Dr. Raffaele received his MD from Hahnemann University Medical School in 1989, completed his residency at The New York Hospital/ Cornell University Medical Center, and was a clinical assistant professor of medicine at Dartmouth Medical School. Dr. Raffaele is board certified in internal medicine and is a diplomat of A4M. Dr. Raffaele has been featured in Newsday, ABC World News Tonight, NPR, The Today Show and The New York Times. Jerry Fortunato, COO Since joining PhysioAge in 2002, Jerry has been responsible for managing all business operations: business strategy, marketing & branding, finance, product management, patient relationship management, systems design & development and information technology support. Jerry received his MBA from Rutgers Business School and his BS in Finance from Rutgers College. Jochen Kumm, PhD Designed and developed the PhysioAge Systems software platform as well as the algorithms used to calculate physiological ages and the overall PhysioAge®. Dr. Kumm holds a Physicum in Medicine from Heidelberg University, a BA in Biology from Harvard University and a PhD in Biological Sciences from Stanford University. Dr. Kumm is the Director of Biomathematics at the Stanford Genome Technology Center in Palo Alto, CA. 3 P ractice Franchise Designed by doctors for doctors Learn how our industry-leading expertise and proven business model will: • Launch your cash practice • Build your patient base • Run your practice smoothly • Allow you to spend more time with patients Without restricting your practice style You practice medicine as you see fit The PhysioAge Practice Franchise is your opportunity to join our expanding team of select physicians nationwide. When you open the next PhysioAge Medical Group, you’re not just an affiliate – you’re a Partner. As a Partner, you’ll be able to fully leverage the clinical and operational expertise we’ve attained over the past 15 years without reinventing the wheel. Each location is independently owned and operated, and each Partner retains the liberty to practice medicine as they wish. Our turnkey practice franchise is designed to allow you to spend less time setting up & managing your business, so you can spend more time managing patients. Our experts will help you get your new practice off the ground with all the forms, brochures, stationary and other marketing materials you need to get started. We’ll conduct a market survey to make sure you’re competitively priced. We’ll set up your IT systems and train your staff on every operational aspect of running your practice. Our proprietary Next-Generation Physical Exam will demonstrate the benefits of your treatment while setting you apart from the competition. By leveraging our brand identity, you’ll project the same professional image we’ve carefully cultivated over the years. You’ll be listed on our website as a member of our team, along with a special section dedicated to your practice. We’ll design & manage a targeted local marketing campaign and share the cost with you. Our call center is staffed with highly-trained professionals who will take calls for your office and turn prospects into patients. We’ll even schedule their appointments and manage the patient intake process. Your site: www.PhysioAge.com You’ll learn how to use our clinical guidelines and protocols to deliver the very best in patient care through a 3-day training course here in our NYC office. While you’re here, you’ll experience what it’s like to become a PhysioAge patient, including biomarker testing and 2-hour initial consultation. You’ll gain a deep understanding of the intricacies of managing hormones in diverse patient cases by working directly with our physicians. As you encounter difficult cases in your clinical practice, you’ll be able to call on our expertise with ongoing clinical support (available in most states). “Spend less time managing your business and more time managing your patients” As a PhysioAge Partner, you’ll have a team of qualified professionals behind you to help in the day-to-day management of your patients and your practice. Your success is our success. 4 Comprehensive Marketing Support & Campaign Management One of your greatest challenges is to build your patient base. How do you find more patients? PhysioAge can help fill your practice by creating and managing a comprehensive plan that includes all aspects of marketing your practice: • Advertising strategy: online advertising, SEO, PR, social media, seminars, etc. • Professional marketing collateral design • Exclusive use of the PhysioAge.com website for your practice • Hormone Therapy Seminar presentation We’ll even contribute to your marketing budget so you can fill your practice quickly. Clinical Protocols & Support In addition to one-on-one training with our senior physicians, Partners will receive a standardized Clinical Treatment Guide that details every aspect of the PhysioAge Protocols and captures our years of clinical experience. As questions arise in day-to-day patient management, we’ll be on call to provide treatment advice based on the specifics of the case at hand. • One-on-One training on PhysioAge Clinical Protocols Physician Partner Requirements • Board-Certified or Board Eligible in a discipline that involves patient management • A4M Fellowship for Anti-Aging and Regenerative Medicine - Modules 1&2 -OR WorldLink Medical Parts I, II and III • Continuing Medical Education related to age management medicine • Approval by our Medical Advisory Board • 3 days face-to-face in our NYC practice • Full Initial Consultation as a new patient • Access to our physicians via forum, phone & e-mail • Clinical case review and recommendations (in most states) Operational & Administrative Support Contact Jerry Fortunato, COO, at 877-888-3210 or Jerry @PhysioAge.com for more information. How do you make it all work flawlessly? You need standardized systems, workflows and operational protocols that will guide your practice through the patient lifecycle without a hitch. As a PhysioAge Partner, you’ll be able to take advantage of the same systems and protocols we developed and refined over the past 15 years while spending less time answering the phone. • Call center support – we’ll take some or all of your calls • Sales support – we’ll convert callers into patients • Patient intake – we’ll manage all new patient documentation • Custom-built operational software platform (coming soon) • New patient enrollment procedures & documentation • Follow-up management protocols In addition to providing customized forms and documentation, we’ll train your staff on how to use them in your practice. Experienced professionals in our call center will take incoming calls, answer questions, manage the intake process and schedule appointments. Plus: • Exclusive discounts on pharmacy, labs, supplements, etc. • Proprietary Next-Generation Physical Exam (see next page) 5 N ext-Generation Physical Exam How well are your patients aging? The first step to aging well is knowing how well you’re aging • • • • • Increase patient retention Monitor physiological age over time Demonstrate the effects of your treatment Reinforce the value you provide Save time interpreting results PhysioAge Systems uses a battery of extensively-tested biomarkers of the health of important physiological systems. We use them to establish a baseline of where our patients are in the aging process, a “the PhysioAge Composite”, and then to follow over time how well their programs are working. This is the crux of the difference between our approach to managing aging and that of most other practices. We believe it’s important to measure the effect of our programs on the arteries, brain, bones, skin, muscle, etc., and adjust therapy to optimize each system’s function. After all, would you prescribe blood pressure medication without checking blood pressure? Biomarkers of Aging To collect the data needed to develop this system, we conducted an in-depth study of 120 subjects over the past few years - the first study of its kind. Working with a top Stanford University statistician, we analyzed correlations among various biomarkers to develop the algorithms used in the calculation of the physiological age of important organ systems. Then we developed the “the PhysioAge Composite” a weighted composite index of all underlying ages. Using the six biomarkers of aging described below, the PhysioAge Composite is able to explain 84% of the variance of the aging process. To our knowledge, no other system comes close to this benchmark in measuring the physiological age of important organ systems. Our advanced reports will objectively demonstrate the effects of your treatment protocols on important organ systems in a way patients can easily understand. Since the results of many of these biomarkers can be improved through the proper use of age management therapies, your patients can potentially watch their physiological age stabilize or even decrease over time. Comprehensive Reports with PhysioAge Composite Once all data has been entered into our proprietary web-based system, a comprehensive report will be available for downloading. This report will contain the patient’s individual physiological ages as well as their overall “the PhysioAge Composite”. Future versions of this report will feature a detailed interpretive analysis of the data in the context of the patient’s individual medical history. This “intelligent report” will save you hours of time for each patient. Access to the PhysioAge Systems Web Portal Your patients will have ongoing access to our proprietary web portal where they can fill out questionnaires, browse their results and download reports. Download our latest report at www.PhysioAgeSystems.com 6 Biomarkers of Aging CardioAge – Arterial Stiffness Testing with SphygmoCor by Atcor Medical • Measures the suppleness of your arteries using pulse wave analysis • Assesses your cardiovascular risk by measuring augmentation pressure PulmoAge – Pulmonary Function Testing with Midmark Spirometer • Measures forced expiratory volume (FEV1/FCV), which is highly correlated with age • Predicts all-cause mortality, not just from pulmonary disease NeuroAge – Cognitive Assessment Testing with CNS Vital Signs • Measures the most highly age-sensitive aspects of cognitive function using a computerized battery of tests • Functions as an effective screen for mild congnitive impairment and Alzheimer’s disease CutoAge – Skin Elasticity Testing with C+K Cutometer • Assesses the elasticity of the skin with the same instrument used in numerous clinical trials of OTC and pharmaceutical skin care products • Determines the propensity to develop wrinkles by measuring elasticity, firmness, and resistance to stress ImmunoAge – Immune Function Testing by UCLA School of Medicine (blood) • Measures the health of the immune system using proprietary algorithms of standard immune subsets • Utilizes cutting-edge molecular markers for senescent and naïve T-cells Standard Equipment SphygmoCor CP by Atcor Medical • The gold standard in central blood pressure management • Used in more clinical studies than any other similar device • Takes a 10-second snapshot of the radial arterial pressure wave and derives the ascending aortic pressure wave • Adopted by The Mayo Clinic for use in hypertension screening Cutometer MPA580 by C+K Electronics • The gold standard in dermatology to measure skin elasticity • Uses gentle suction to draw the skin into the aperture of the probe, where penetration depth is determined by an optical measuring system. • Displays the resistance of the skin to be sucked up by negative pressure (firmness) and its ability to return into its original position (elasticity) as curves. IQspiro by Midmark Diagnostics • Combines a digital spirometer with innovative software that makes it fast and easy to capture, interpret and retrieve patient information. • Features real-time feedback and coaching that ensures you collect consistent measurements every time. Biomarker Equipment Setup We can setup your equipment and provide training and ongoing technical support. TelomerAge – Telomere Length Measurement by Repeat Diagnostics (blood) • Measures the ends of the telomeres, the caps at the ends of your chromosomes that act as a molecular clock by shortening with every cell division • Telomere shortening is highly correlated in numerous studies with aging and many disease states 7 30 Central Park South New York, NY 10019 For more information, Contact Jerry Fortunato, COO, 877-888-3210 Jerry @PhysioAge.com www.PhysioAgeSolutions.com PhysioAge is a registered trademark of PhysioAge Medical Group P.C. PhysioAge Systems, PulmoAge, NeuroAge, CutoAge, ImmunoAge and TelomerAge are trademarks of PhysioAge Systems LLC. SphygmoCor is a registered trademark of Atcor Medical Pty Ltd IQspiro is a registered trademark of Midmark Corp. CNS Vital Signs is a registered trademark of CNS Vital Signs, LLC Cutometer is a registered trademark of Courage + Khazaka electronic GmbH 8 © 2009 - 2012 PhysioAge Practice Solutions LLC
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