Electronic Supplementary Material (ESI) for Molecular BioSystems.
This journal is © The Royal Society of Chemistry 2015
Table S4: Proteins and metabolites found differentially expressed in the comparison of INS-1E β cells treated with palmitate+GLP-1 vs cells treated
with palmitate (grey lines when fold change ≥1.5).
Fold palm+GLP1/palm
+2.44
+2.2
-1.23
-1.14
+1.30
+1.69
-2.48
-1.46
-1.45
-1.35
-1.28
-1.24
-1.18
-1.18
-1.14
+1.12
+1.22
+1.23
+1.25
+1.32
+1.37
+1.41
+1.49
+1.61
-1.34
-1.12
+1.09
ID
P10860
P81155
Name
Glutamate dehydrogenase 1
Voltage-dependent anion-selective channel protein
2
P16036
Phosphate carrier protein
Q9R1Z0
Voltage-dependent anion-selective channel protein
3
Q9Z2L0
Voltage-dependent anion-selective channel protein
1
Q05962
ADP/ATP translocase 1
P21571
ATP synthase-coupling factor 6
P29419
ATP synthase subunit e
P04636
Malate dehydrogenase, mitochondrial
Q68FU3
Electron transfer flavoprotein subunit beta
P15999
ATP synthase subunit alpha
P62898
Cytochrome c, somatic
P10888
Cytochrome c oxidase subunit 4 isoform 1
P56574
Isocitrate dehydrogenase [NADP]
P13086
Succinyl-CoA ligase [ADP/GDP-forming] subunit
alpha
P35171
Cytochrome c oxidase subunit 7A2
P10719
ATP synthase subunit beta
Q66HF1
NADH-ubiquinone oxidoreductase 75 kDa subunit
P00507
Glutamic-oxaloacetic transaminase 2
P11608
ATP synthase protein 8
P11240
Cytochrome c oxidase subunit 5A
Q99NA5
Isocitrate dehydrogenase [NAD] subunit alpha
P11507
Sarcoplasmic/endoplasmic reticulum calcium
ATPase 2
Q06647
ATP synthase subunit O
Q60587
Trifunctional enzyme subunit beta
Q9WVK7
Hydroxyacyl-coenzyme A dehydrogenase
HMDB13130 Glutarylcarnitine
Function
Location
aminoacid metabolism
channels and transporter
mito
mito
channels and transporter
channels and transporter
mito
mito
channels and transporter
mito
channels and transporter
krebs cycle/ATP production
krebs cycle/ATP production
krebs cycle/ATP production
krebs cycle/ATP production
krebs cycle/ATP production
krebs cycle/ATP production
krebs cycle/ATP production
krebs cycle/ATP production
krebs cycle/ATP production
mito
mito
mito
mito
mito
mito
mito
mito
mito
mito
krebs cycle/ATP production
krebs cycle/ATP production
krebs cycle/ATP production
krebs cycle/ATP production
krebs cycle/ATP production
krebs cycle/ATP production
krebs cycle/ATP production
krebs cycle/ATP production
mito
mito
mito
mito
mito
mito
mito
mito
krebs cycle/ATP production
Lipid metabolism
Lipid metabolism
Lipid metabolism
mito
mito
mito
mito
+1.11
+1.82
-1.29
-1.18
-1.15
+1.19
+1.45
-1.44
-1.22
-1.24
HMDB00552 3-Methylglutarylcarnitine
P07153
Dolichyl-diphosphooligosaccharide--protein
glycosyltransferase subunit 1
P85834
Elongation factor Tu
P67779
Prohibitin
Q4FZT0
Stomatin-like protein 2
Q5XIH7
Prohibitin-2
Q5SGE0
Leucine-rich PPR motif-containing protein
O35796
Complement component 1 Q subcomponentbinding protein
Q9R063
Peroxiredoxin-5
P63039
60 kDa heat shock protein
-1.22
P48721
Stress-70 protein
+1.37
P26772
10 kDa heat shock protein
+1.52
-1.58
-1.53
-1.45
-1.37
+1.41
P0C2N5
P62804
A9UMV8
A7VJC2
Q00715
P07340
+1.32
P21807
+1.85
P70580
+1.37
Q5PQS3
-1.3
P14562
+1.14
P59215
+1.18
P04897
-1.43
Q8VHQ7
Histone-lysine N-methyltransferase SUV420H1
Histone H4
Histone H2A.J
Heterogeneous nuclear ribonucleoproteins A2/B1
Histone H2B type 1
Sodium/potassium-transporting ATPase subunit
beta-1
Peripherin
Lipid metabolism
metabolism/miscellaneous
mito
mito
mitochondrial protein processing
mitochondrial protein processing
mitochondrial protein processing
mitochondrial protein processing
other/unknown function
oxidative stress/apoptosis
mito
mito
mito
mito
mito
mito
oxidative stress/apoptosis
protein synthesis/translation regulation/protein
folding/ER stress
protein synthesis/translation regulation/protein
folding/ER stress
protein synthesis/translation regulation/protein
folding/ER stress
epigenetic regulation
other/unknown function
other/unknown function
other/unknown function
other/unknown function
channels and transporter
mito
mito
cytoskeleton related proteins
Membrane-associated progesterone receptor
component 1
Ventricular zone-expressed PH domain-containing
protein homolog 1
Lysosome-associated membrane glycoprotein 1
hormones/growth factors/receptors/neuropeptides
Guanine nucleotide-binding protein G(o) subunit
alpha
Guanine nucleotide-binding protein G(i) subunit
alpha-2
Synaptotagmin-like protein 4
signal transduction
other/unknown function
Proteasoma/Lysosoma/Autophagy
signal transduction
vescicle transport/signal transduction
mito
mito
Nucleus
Nucleus
Nucleus
Nucleus
Nucleus
Plasma
Membrane
Plasma
Membrane
Plasma
Membrane
Plasma
Membrane
Plasma
Membrane
Plasma
Membrane
Plasma
Membrane
Plasma
Membrane
+1.15
P54311
vescicle transport/signal transduction
P63025
Guanine nucleotide-binding protein G(I)/G(S)/G(T)
subunit beta-1
Guanine nucleotide-binding protein G(I)/G(S)/G(T)
subunit beta-2
Vesicle-associated membrane protein 3
+1.15
P54313
+1.16
+1.23
Q9Z1X1
Extended synaptotagmin-1
vescicle transport/signal transduction
+1.19
-2.18
-1.15
+1.20
+1.22
+1.61
+1.41
+1.15
-1.37
P60711
P04797
P16638
Q62812
Q5RJR8
Q68FR6
P68255
P62986
P62853
Actin, cytoplasmic 1
Glyceraldehyde-3-phosphate dehydrogenase
ATP-citrate synthase
Myosin-9
Leucine-rich repeat-containing protein 59
Elongation factor 1-gamma
14-3-3 protein theta
Ubiquitin-60S ribosomal protein L40
40S ribosomal protein S25
+1.12
P62425
60S ribosomal protein L7a
+1.16
P05197
Elongation factor 2
+1.27
P05426
60S ribosomal protein L7
+1.30
P23358
60S ribosomal protein L12
+1.52
P34058
Heat shock protein HSP 90-beta
+1.79
P41123
60S ribosomal protein L13
+2.08
P17077
60S ribosomal protein L9
+1.18
P38406
-1.18
-1.13
+1.11
+1.14
P09527
P10536
P61107
P60881
Guanine nucleotide-binding protein G(olf) subunit
alpha
Ras-related protein Rab-7a
Ras-related protein Rab-1B
Ras-related protein Rab-14
Synaptosomal-associated protein 25
cytoskeleton related proteins
glucose metabolism
Lipid metabolism
other/unknown function
other/unknown function
other/unknown function
oxidative stress/apoptosis
posttranslational modification/ubiquitination
protein synthesis/translation regulation/protein
folding/ER stress
protein synthesis/translation regulation/protein
folding/ER stress
protein synthesis/translation regulation/protein
folding/ER stress
protein synthesis/translation regulation/protein
folding/ER stress
protein synthesis/translation regulation/protein
folding/ER stress
protein synthesis/translation regulation/protein
folding/ER stress
protein synthesis/translation regulation/protein
folding/ER stress
protein synthesis/translation regulation/protein
folding/ER stress
signal transduction
vescicle transport/signal transduction
vescicle transport/signal transduction
vescicle transport/signal transduction
vescicle transport/signal transduction
vescicle transport/signal transduction
vescicle transport/signal transduction
Plasma
Membrane
Plasma
Membrane
Plasma
Membrane
Plasma
Membrane
cyto
cyto
cyto
cyto
cyto
cyto
cyto
cyto
cyto
cyto
cyto
cyto
cyto
cyto
cyto
cyto
cyto
cyto
cyto
cyto
cyto
+1.41
+1.92
-1.27
-1.39
Q62636
Q9JK11
P04785
P18418
Ras-related protein Rap-1b
Reticulon-4
Protein disulfide-isomerase
Calreticulin
-1.23
P52555
Endoplasmic reticulum resident protein 29
-1.21
P06761
78 kDa glucose-regulated protein
-1.2
Q63081
Protein disulfide-isomerase A6
-1.19
Q63617
Hypoxia up-regulated protein 1
-1.15
Q66HD0
Endoplasmin
+1.47
P35565
Calnexin
-1.41
P01322
Insulin-1
vescicle transport/signal transduction
other/unknown function
posttranslational modification/ubiquitination
protein synthesis/translation regulation/protein
folding/ER stress
protein synthesis/translation regulation/protein
folding/ER stress
protein synthesis/translation regulation/protein
folding/ER stress
protein synthesis/translation regulation/protein
folding/ER stress
protein synthesis/translation regulation/protein
folding/ER stress
protein synthesis/translation regulation/protein
folding/ER stress
protein synthesis/translation regulation/protein
folding/ER stress
hormones/growth factors/receptors/neuropeptides
-1.34
P01323
Insulin-2
hormones/growth factors/receptors/neuropeptides
-1.35
O35547
Long-chain-fatty-acid--CoA ligase 4
Lipid metabolism
+1.15
P63018
Heat shock cognate 71 kDa protein
-1.18
-1.11
-1.08
+1.02
+1.07
+1.11
+1.14
+1.16
+1.17
+1.18
+1.19
+1.19
+1.20
HMDB00062
HMDB00123
HMDB00517
HMDB00161
HMDB00162
HMDB00177
HMDB00148
HMDB00167
HMDB00159
HMDB00883
HMDB00182
HMDB00687
HMDB00191
protein synthesis/translation regulation/protein
folding/ER stress
aminoacid metabolism
aminoacid metabolism
aminoacid metabolism
aminoacid metabolism
aminoacid metabolism
aminoacid metabolism
aminoacid metabolism
aminoacid metabolism
aminoacid metabolism
aminoacid metabolism
aminoacid metabolism
aminoacid metabolism
aminoacid metabolism
L-carnitine
Glycine
L-Arginine
L-Alanine
L-Proline
L-Histidine
L-Glutamic acid
L-Threonine
L-Phenylalanine
L-Valine
L-Lysine
L-Leucine
L-Aspartic Acid
cyto
ER
ER
ER
ER
ER
ER
ER
ER
ER
Extracellular
Space
Extracellular
Space
Extracellular
Space
other
other
other
other
other
other
other
other
other
other
other
other
other
other
+1.21
+1.24
+1.34
+1.38
+1.47
HMDB00696
HMDB00187
HMDB00158
HMDB00214
HMDB00168
L-Methionine
L-Serine
L-Tyrosine
Ornithine
L-Asparagine
aminoacid metabolism
aminoacid metabolism
aminoacid metabolism
aminoacid metabolism
aminoacid metabolism
other
other
other
other
other