DNA, RNA, and
protein purification
Catalog supplement 2016
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Contents
MACHEREY-NAGEL – Bioanalysis catalog supplement 2016
This Bioanalysis catalog supplement 2016 is an addition to the main Bioanalysis catalog 2014 / 2015. The new
MACHEREY-NAGEL products are sorted according to the product chapters in the main catalog.
Product
Page
Clean-up
NGS clean-up and size selection
NucleoMag® NGS Clean-up and
Size Select
Clean-up and tunable size-selection of NGS library
preparation reactions
4
NucleoSpin® RNA Plus
Ultra-fast isolation of high-quality RNA including lysate
clearing and gDNA removal in one step
5
NucleoZOL
High yield RNA isolation from all kind of sample material
6
Exosome Precipitation Solution
(Serum / Plasma), (Urine)
Simple and efficient exosome precipitation for quantitative
miRNA isolation
7
RNA
RNA from cells and tissue
MicroRNA
Genomic DNA
Genomic DNA from blood and biological fluids
NucleoSpin® Blood L Vacuum
Convenient and time-saving DNA purification from large
blood volumes under vacuum
8
Isolation of total DNA from hard-to-lyse microbial cultures
with bead-supported homogenization
9
NucleoSpin® 96 DNA FFPE
NucleoMag® DNA FFPE
Xylene-free high-throughput isolation and decrosslinking of
DNA from FFPE samples
10
11
NucleoSpin® Forensic Filters
Incubation and lysate separation of solid sample carriers in
one tube
12
Genomic DNA from microorganisms
Contents
NucleoSpin® Microbial DNA
Genomic DNA from FFPE samples
Genomic DNA from forensic samples
Viral RNA and DNA
Viral RNA and DNA from serum and plasma
NucleoSpin® Virus
Simultaneous isolation of viral RNA and DNA
13
Manual separation of magnetic beads in 1.5 mL or 2 mL
reaction tubes
14
For processing of NucleoBond® Columns by gravity flow
14
Accessories
Equipment
NucleoMag® SEP Mini
NucleoMag® SEP Maxi
NucleoBond® Smart Rack
Starter Set Midi
Consumables
NucleoSpin® Bead Tubes
2
Magnetic separation in 50 mL tubes
14
For processing of NucleoSpin Midi / L Columns under vacuum
14
®
Efficient cell disruption
14
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MACHEREY-NAGEL · Company updates
MACHEREY-NAGEL – Quality, innovation, and support
Since 1911, MACHEREY-NAGEL stands for highly reliable analytical products made in Germany. Based on
more than 100 years of experience, the company has focused on continuous improvement and innovations to
offer up-to-date solutions of outstanding quality.
MACHEREY-NAGEL –
Facilities and resources
Throughout MACHEREY-NAGEL’s centennial history, the companyʼs facilities have constantly been adapted and renewed. Just
recently the production and the warehouse facilities have been
modernized and enlarged. State-of-the-art high-quality equipment
meets optimal production and delivery requirements.
MN headquarters in Düren, Germany
To share our long lasting knowledge and expertise with customers and distributors, a new training center has been established at
the MACHEREY-NAGEL headquarters in Düren. A dedicated team
of scientists and product specialists with extensive practical and
theoretical expertise is committed to train our clients and provide
maximal support.
MACHEREY-NAGEL –
Packaging according to up-to-date standards
To meet the demands of providing a reliable, high quality product,
MACHEREY-MAGEL is always looking for enhancements and
continuous optimizations of products and production processes.
As of June 2015, all MACHEREY-NAGEL products will be labeled
according to the Globally Harmonized System of Classification
(GHS), the new world-wide-standardized system for classification
and labeling of chemicals on product labels and Material Safety
Data Sheets (MSDS). The most noticeable change is the new
diamond shaped hazardous icon which replaced the previously
labeled orange square symbols.
In addition, all liquids included in the MACHEREY-NAGEL
Bioanalysis product line will be provided in new Nalgene® round
bottles. These bottles provide better handling and a wider opening,
allowing easier and more precise pipetting. The new bottles have
shown improved stability and have helped streamline production
processes.
www.mn-net.com
Hazardous icons according to GHS
Nalgene® round bottles
3
Company updates
MN Training-Center symbol
NGS clean-up and size selection
NucleoMag® NGS Clean-up and Size Select
Applications*
Clean-up and size selection of NGS (Next Generation Sequencing) library preparation reactions
Features
• Convenient magnetic-bead technology
– easy to adjust for different applications or workflows
– optimal scalability for manual and automated processing
• Tunable size selection from 150 bp to 800 bp – highest flexibility for custom-specific applications
Clean-up
Product at a glance
Parameter
NucleoMag® NGS Clean-up and Size Select
Technology
Magnetic-bead technology
Format
Highly reactive superparamagnetic beads
Processing
Manual or automated
Sample material
Reaction mixtures from common NGS library kits
Amount of sample material
7.5 pg–5 μg
Fragment size
Tunable: 150–800 bp
Input volume
50–150 μL
Typical recovery
> 80 %
Elution volume
10–100 μL
Preparation time
30–45 min/96 preps
Ordering information
Product
NucleoMag® NGS Clean-up and Size
Select
Material to be supplied by the user
Pack of
Specification
REF
5 mL NucleoMag® NGS Bead Suspension
50 mL as above
500 mL as above
Pack of Specification
744970.5
744970.50
744970.500
REF
Square-well Block (separation plate)
4 96-well blocks with 2.1 mL square-wells
24 as above
740481
Elution Plate, U-bottom (elution plate)
24 96-well microplates with 300 μL u-bottom
wells, including Self-adhering Foil
740486.24
Product accessories
Pack of Specification
740481.24
REF
NucleoMag® SEP
1 magnetic separator, for use with 96-well
plates
744900
NucleoMag® SEP Mini
1 magnetic separator, for use with 1.5 mL or
2 mL reaction tubes (12 positions)
744901
NucleoMag® SEP Maxi
1 magnetic separator, for use with 50 mL tubes
(4 positions)
744902
For separate kit components see “Accessories” page 149 of the main catalog Bioanalysis 2014 / 2015.
* Kits to be used for research purposes only (see page 15)
4
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MicroRNA
® gDNA
NucleoSpin
ded
olumn inclu
Removal C
NucleoSpin RNA Plus
®
Applications*
New generation of RNA isolation from cells and tissue
Features
• NucleoSpin® gDNA Removal Column included – no time-consuming rDNase digestion
• Lysate clearing and gDNA removal in one step – quick and convenient handling
• New efficient lysis buffer – no ß-mercapthoethanol or TCEP necessary
Product at a glance
NucleoSpin® RNA Plus
Technology
Two column silica-membrane system
1. column for DNA removal
2. column for RNA isolation
Format
Mini spin columns
Sample material
< 1 x 107 cultured cells,
< 109 bacterial cells,
< 108 yeast cells,
< 30 mg human / animal tissue
Fragment size
> 200 nt
Typical yield
HeLa cells 5 x 106: 40–60 μg
Mouse liver 20 mg: 80–100 μg
Mouse kidney 20 mg: 40–70 μg
Mouse spleen 5 mg: 30–60 μg
A260/A280
1.9–2.1
A260/A230
1.8–2.5
Typical RIN (RNA integrity number)
>9
Elution volume
30–120 μL
Preparation time
20 min/6 preps
Binding capacity
200 μg
Typical downstream applications
Real-time RT-PCR, Northern blotting, primer extension, array technology, RNase protection assays
RNA
Parameter
Ordering information
Product
NucleoSpin® RNA Plus
Preps Specification
REF
10 NucleoSpin® RNA Plus Columns with Collection 740984.10
Tubes, NucleoSpin® gDNA Removal Columns
with Collection Tubes, Collection Tubes (2 mL
and 1.5 mL), buffers
740984.50
50 as above
740984.250
250 as above
For separate kit components see “Accessories” page 149 of the main catalog Bioanalysis 2014 / 2015.
* Kits to be used for research purposes only (see page 15)
www.mn-net.com
5
RNA from cells and tissue
NucleoZOL
eparation
No phase s
Applications*
High yield total RNA extraction from all kind of samples
Features
• No use of chloroform, no phase separation needed – easy and safe procedure
• Efficient removal of DNA, proteins, and other contaminating compounds – high RNA purity
from any sample material
• Isolation of total RNA in one fraction or small and large RNA in two fractions – flexible use
• Combination with NucleoSpin® RNA Columns possible
Product at a glance
Parameter
NucleoZOL
Technology
One-phase extraction
RNA
Sample material/mL < 1 x 107 cultured cells, bacteria, and yeast,
reagent (scalable)
< 100 mg human / animal / plant tissue,
< 0.4 mL (viral) fluids
Fragment size
Small RNA: 10–200 nt, large RNA: > 200 nt
Typical yield
Total RNA:
Liver:
Kidney, spleen:
Muscle, brain, lung:
Cultured cells:
A260/A280
1.8–2.1
Typical RIN
>9
Elution volume
Flexible
Preparation time
<1h
6–8 μg/mg tissue
3–4 μg/mg tissue
0.5–1.5 μg/mg tissue
4–10 μg/106 cells
Large RNA:
Liver:
Kidney, spleen:
Muscle, brain, lung:
Cultured cells:
5–7 μg/mg tissue
3–4 μg/mg tissue
0.5–1.5 μg/mg tissue
3–8 μg/106 cells
Ordering information
Product
Pack of Specification
REF
NucleoZOL
200 mL NucleoZOL Reagent
740404.200
Related products
NucleoSpin® RNA Clean-up
Preps Specification
REF
10 NucleoSpin® RNA Clean-up Columns with
Collection Tubes, Collection Tubes (2 mL and
1.5 mL), buffers
50 as above
250 as above
740948.10
740948.50
740948.250
* Kits to be used for research purposes only (see page 15)
6
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MicroRNA
Exosome Precipitation Solution (Serum / Plasma)
Exosome Precipitation Solution (Urine)
Applications*
Exosome enrichment for most efficient total RNA isolation from serum and plasma samples, urine, other
body fluids, and cell culture supernatants (serum-free)
Features
• Simple and fast exosome precipitation – avoidance of tedious ultra-centrifugation
• Flexibe sample amount – procedure can be scaled up or down depending on sample volume
Product at a glance
Parameter
Exosome Precipitation Solution
Technology
Precipitation solution
Sample material
Flexible input:
0.1–1 mL serum / plasma (Exosome Precipitation Solution
(Serum / Plasma))
1–10 mL urine (Exosome Precipitation Solution (Urine))
Preparation time
45 min/6 preps
Typical downstream
application
Total RNA isolation (e.g., with NucleoSpin® miRNA Plasma, see
ordering information)
Ordering information
Pack of Specification
REF
Exosome Precipitation Solution
(Serum / Plasma)
2 mL Exosome Precipitation Solution, RNase-free water
12 mL as above
60 mL as above
740398.2
740398.12
740398.60
Exosome Precipitation Solution
(Urine)
12 mL Exosome Precipitation Solution, RNase-free water
50 mL as above
250 mL as above
740399.12
740399.50
740399.250
Related products
Preps Specification
NucleoSpin miRNA Plasma
®
10 NucleoSpin miRNA Columns, Collection Tubes
(2 mL), buffers, RNase-free rDNase
50 as above
250 as above
®
REF
740981.10
740981.50
740981.250
* Kits to be used for research purposes only (see page 15)
www.mn-net.com
7
RNA
Product
Genomic DNA from blood and biological fluids
NucleoSpin® Blood L Vacuum
Applications*
DNA purification from up to 2 mL whole blood using vacuum filtration
Features
• Efficient DNA purification – consistent high yields and complete removal of PCR
inhibitors
• Adapter set for the NucleoVac 96 Vacuum Manifold available – parallel purification
of 24 samples
Genomic DNA
Product at a glance
Parameter
NucleoSpin® Blood L Vacuum
Technology
Silica-membrane technology
Format
Midi spin columns
Sample material
1–2 mL whole blood (human or animal, fresh or frozen, treated
with citrate, heparin, or EDTA)
Fragment size
200 bp–approx. 50 kbp
Typical yield
50–80 μg (2 mL blood)
A260/A280
1.6–1.9
Typical concentration
100–130 ng/μL
Elution volume
2 x 300 μL
Preparation time
75 min/24 preps
Binding capacity
250 μg
Typical downstream
applications
PCR, Southern blotting, enzymatic reactions
Ordering information
Product
NucleoSpin® Blood L Vacuum
Product accessories
NucleoVac 96 Vacuum Manifold
Preps Specification
REF
24 NucleoSpin® Blood L Columns with Collection
Tubes, Collection Tubes (1.5 mL), buffers,
Proteinase K
Pack of Specification
740954.24
REF
1
740681
NucleoVac Vacuum Regulator
1 for controlling of vacuum
740641
Starter Set Midi
1 for processing NucleoSpin® Midi / L Columns
under vacuum on NucleoVac 96 Vacuum
Manifold or similar manifolds, contains
1 Column Holder Midi, 1 Wash Plate Midi,
1 Elution Tube Holder Midi, 24 Dummy
Columns Midi
740744
For separate kit components see “Accessories” page 149 of the main catalog Bioanalysis 2014 / 2015.
* Kits to be used for research purposes only (see page 15)
8
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Genomic DNA from microorganisms
NucleoSpin® Microbial DNA
Applications*
Isolation of total DNA from hard-to-lyse microorganisms
Features
• Suitability for a large variety of starting cultures – high-quality DNA from gram-positive /
gram-negative bacteria, yeast, or fungi with one procedure
• NucleoSpin® Bead Tubes for efficient cell disruption – compatibility with common disruption
devices
• Liquid Proteinase K included – no additional enzyme required
Product at a glance
NucleoSpin® Microbial DNA
Technology
Silica-membrane technology
Format
Mini spin columns
Sample material
< 40 mg wet weight cell pellet (gram-positive bacteria,
gram-negative bacteria, yeast, fungi)
Fragment size
200 bp–approx. 50 kbp
Typical yield
Depends on sample type and disruption method
Approx. 5–25 μg (30 mg wet weight cell pellet)
A260/A280
1.6–2.0
Elution volume
100–200 μL
Preparation time
35 min/prep
Binding capacity
60 μg
Typical downstream
applications
PCR, real-time PCR, Southern blotting, enzymatic reactions
Genomic DNA
Parameter
Ordering information
Product
Preps Specification
NucleoSpin Microbial DNA
®
Product accessories
10 NucleoSpin Microbial DNA Columns,
NucleoSpin® Bead Tubes Type B, Collection
Tubes (2 mL), buffers, Liquid Proteinase K
50 as above
®
Pack of Specification
REF
740235.10
740235.50
REF
NucleoSpin Bead Tubes Type A
50 2 mL tubes with ceramic beads
(as included in the NucleoSpin® Soil kit)
740786.50
NucleoSpin® Bead Tubes Type B
50 2 mL tubes with glass beads
(as included in the NucleoSpin® Microbial
DNA kit)
740812.50
NucleoSpin® Bead Tubes Type C
50 2 mL tubes with corundum
(recommended for yeast disruption)
740813.50
®
For separate kit components see “Accessories” page 149 of the main catalog Bioanalysis 2014 / 2015.
* Kits to be used for research purposes only (see page 15)
www.mn-net.com
9
Genomic DNA from FFPE samples
NucleoSpin® 96 DNA FFPE
Applications*
Isolation of genomic DNA from formalin-fixed, paraffin-embedded samples (fresh or archived) in 96-well
plate format
Features
• Blue colored Paraffin Dissolver (patent pending) for easy paraffin removal – no use
of harmful organic solvents
• Decrosslinking buffer to eliminate formalin crosslinking – high-quality DNA for improved performance in downstream applications (e.g., PCR)
• Processing under vacuum or by centrifugation – suitability for manual and automated processing
Genomic DNA
Product at a glance
Parameter
NucleoSpin® 96 DNA FFPE
Technology
Silica-membrane technology
Format
96-well plates
Processing
Manual or automated, vacuum or centrifugation
Sample material
< 10 mg tissue, < 15 mg paraffin
Fragment size
50 bp–approx. 5 kbp
Typical recovery
Depending on sample amount and quality
DNA quality
Strongly depending on sample quality
Elution volume
100 μL
Preparation time
60 min/plate (excl. lysis)
Binding capacity
20 μg
Ordering information
Product
NucleoSpin 96 DNA FFPE
®
Product accessories
Preps Specification
REF
1 x 96 NucleoSpin DNA FFPE Binding Plate,
MN Wash Plate, MN Square-well Block,
Round-well Block, Rack of Tube Strips,
Self-adhering Foil, Paraffin Dissolver,
buffers, Proteinase K
4 x 96 as above
740240.1
®
Pack of Specification
740240.4
REF
NucleoVac 96 Vacuum Manifold
1
740681
NucleoVac Vacuum Regulator
1 for controlling of vacuum
740641
For separate kit components see “Accessories” page 149 of the main catalog Bioanalysis 2014 / 2015.
* Kits to be used for research purposes only (see page 15)
10
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Genomic DNA from FFPE samples
NucleoMag® DNA FFPE
Applications*
Isolation of genomic DNA from formalin-fixed, paraffin-embedded samples (fresh or archived) with
magnetic-bead technology
Features
• Blue colored Paraffin Dissolver (patent pending) for convenient paraffin removal – no need for harmful organic
solvents
• Removal of formalin crosslinking by efficient decrosslinking buffer – high-quality DNA for improved performance
in downstream applications (e.g., PCR)
• Magnetic-bead technology – highest flexibility and easy adaption for automated use
Product at a glance
NucleoMag® DNA FFPE
Technology
Magnetic-bead technology
Format
Highly reactive superparamagnetic beads
Processing
Manual or automated
Sample material
< 5 mg tissue, < 15 mg paraffin
Fragment size
50 bp–approx. 5 kbp
Typical recovery
Depending on amount and quality of sample
DNA quality
Strongly depending on sample quality
Elution volume
> 25 μL
Preparation time
120 min/96 preps
Binding capacity
0.4 μg/μL beads
Ordering information
Product
NucleoMag DNA FFPE
®
Material to be supplied by the user
E.g., Rack of Tube Strips (lysis tubes)
Preps Specification
REF
1 x 96 NucleoMag B-Beads, buffers, Proteinase K
4 x 96 as above
744320.1
744320.4
®
Pack of Specification
4 sets 1 set consists of 1 rack, 12 strips with 8 tubes
each, and 12 cap strips
24 sets as above
REF
740477
740477.24
Square-well Block (separation plate)
4 96-well blocks with 2.1 mL square wells
24 as above
740481
740481.24
E.g., Elution Plate U-bottom (elution
plate)
24 96-well microplates with 300 μL u-bottom
wells
740486.24
Product accessories
Pack of Specification
REF
NucleoMag SEP
1 magnetic separator, for use with 96-well plates 744900
NucleoMag® SEP Mini
1 magnetic separator, for use with 1.5 mL or
2 mL reaction tubes (12 positions)
740901
NucleoMag® SEP Maxi
1 magnetic separator, for use with 50 mL tubes
(4 positions)
740902
®
For separate kit components see “Accessories” page 149 of the main catalog Bioanalysis 2014 / 2015.
* Kits to be used for research purposes only (see page 15)
www.mn-net.com
11
Genomic DNA
Parameter
Genomic DNA from forensic samples
NucleoSpin® Forensic Filters
EO treated plastic materials
Applications*
Incubation and lysate separation of swabs, denim, cigarette butts, or other solid sample carriers
Features
• Lysis and lysate separation in one tube – no sample transfer, no extra pipetting steps
• Special filter design – absolutely leak-proof and compatible with all typical lysis buffers
• Complete DNA recovery and maximum process reliability – no DNA loss
• Collection Tube with lid – no cross-contamination
Genomic DNA
Product at a glance
Parameter
NucleoSpin® Forensic Filters
Technology
Semi-permeable basket
Sample material
Swabs, denim, cigarette butts, others
Maximum volume capacity
800 μL
Forensic quality
Ethylene oxide treated
Typical downstream applications
DNA purification (e.g., with NucleoSpin® Tissue, NucleoSpin®
Tissue XS, NucleoSpin® 8 / 96 Trace, NucleoMag® Forensic,
NucleoMag® 96 Trace)
Procedure
Sample preparation
Prepare
Place sample into filter
and add lysis buffer
Incubate
Nucleic acids are released
without filter leakage
DNA purification
Separate
Spin filter to separate carrier
and to collect lysate
Follow up
(e.g., NucleoSpin® / NucleoMag®
DNA isolation kits)
Ordering information
Product
Preps Specification
NucleoSpin Forensic Filters
®
NucleoSpin® Forensic Filters (Bulk)
REF
10 NucleoSpin Forensic Filters with Collection
Tubes (2 mL), blistered, ethylene oxide treated
50 as above
250 as above
®
50 NucleoSpin® Forensic Filters, Collection Tubes
(2 mL), bulk packed, ethylene oxide treated
250 as above
1000 as above
740988.10
740988.50
740988.250
740988.50B
740988.250B
740988.1000B
For separate kit components see “Accessories” page 149 of the main catalog Bioanalysis 2014 / 2015.
* Kits to be used for research purposes only (see page 15)
** For more detailed information regarding the kits, please see the main Bioanalysis Catalog 2014 / 2015 or visit www.mn-net.com.
12
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Viral RNA and DNA from serum and plasma
l RNA and
vira
One kit for
NucleoSpin Virus
®
DNA
Applications*
Purification of viral RNA and DNA from cell-free biological fluids (human or animal)
Features
• Processing of up to 400 μL starting volume – maximal recovery of viral nucleic acids
• Liquid Proteinase K included – convenient and highly efficient sample lysis
Product at a glance
Parameter
NucleoSpin® Virus
Technology
Silica-membrane technology
Format
Mini spin columns
Sample material
< 200 μL serum, plasma, cell-free biological fluids
(< 400 μL with two loading steps)
Fragment size
100 bp–approx. 50 kbp
Elution volume
30 μL
Preparation time
50 min/6 preps
Binding capacity
25 μg
Typical downstream applications
qRT-PCR, qPCR, enzymatic reactions
Product
Preps Specification
NucleoSpin Virus
®
Product accessories
Liquid Proteinase K
10 NucleoSpin Virus Columns with Collection
Tubes, Collection Tubes (2 mL and 1.5 mL),
buffers, Carrier RNA, Liquid Proteinase K
50 as above
250 as above
®
Pack of
REF
740983.10
740983.50
740983.250
REF
5 mL ready-to-use liquid Proteinase K, recombinant 740396
For separate kit components see “Accessories” page 149 of the main catalog Bioanalysis 2014 / 2015.
* Kits to be used for research purposes only (see page 15)
www.mn-net.com
13
Viral RNA and DNA
Ordering information
Accessories
Equipment
Product
NucleoBond equipment
Pack of Specification
REF
®
NucleoBond® Smart
Rack
1 for use with NucleoBond® Xtra Midi, Xtra Maxi,
Xtra BAC, AX 20, AX 100, AX 500, AX 2000,
and AX 10000 Columns
740413
1 for processing NucleoSpin® Midi / L Columns
under vacuum on the NucleoVac 96 Vacuum
Manifold or similar manifolds, contains 1 Column Holder Midi, 1 Wash Plate Midi, 1 Elution
Tube Holder, 24 Dummy Columns Midi
740744
NucleoMag®
SEP Mini
1 magnetic separator, for use with 1.5 mL or
2 mL reaction tubes (12 positions)
744901
NucleoMag®
SEP Maxi
1 magnetic separator, for use with 50 mL tubes
(4 positions)
744902
NucleoSpin® equipment
Starter Set Midi
Accessories
NucleoMag® equipment
Consumables
Product
NucleoSpin consumables
Pack of Specification
REF
®
14
NucleoSpin® Bead
Tubes Type A
50 2 mL tubes with ceramic beads
(as included in the NucleoSpin® Soil kit)
NucleoSpin® Bead
Tubes Type B
50 2 mL tubes with glass beads
740812.50
(as included in the NucleoSpin® Microbial DNA
kit)
NucleoSpin® Bead
Tubes Type C
50 2 mL tubes with corundum
(recommended for yeast disruption)
744786.50
740813.50
www.mn-net.com
Product use restriction
Trademarks used in this supplement
MACHEREY-NAGEL trademarks
NucleoBond kits and cartridges for nucleic acid purification (anion-exchange chromatography)
NucleoMag kits for purification of DNA and RNA (magnetic-bead technology)
NucleoSpin kits for purification of DNA and RNA (silica-membrane technology)
Trademarks of other companies
Registered trademarks
Nalgene
KingFisher
Thermo Fisher Scientific Inc. (USA)
Thermo Fisher Scientific Inc. (USA)
Trademarks
PCR is patented by Hoffmann La Roche
Disclaimer
All used names and denotations can be brands, trademarks, or registered labels of their respective owner – also if they do
not have a special denotation. To mention products and brands is only a kind of information, i.e., it does not offend against
trademarks and brands and can not be seen as a kind of recommendation or assessment. Regarding these products or
services, we can not grant any guarantees regarding selection, efficiency, or operation.
Product use restriction / Warranty
MACHEREY-NAGEL products are intended for GENERAL LABORATORY USE ONLY!
MACHEREY-NAGEL products are suited for QUALIFIED PERSONNEL ONLY!
MACHEREY-NAGEL products shall in any event only be used wearing adequate PROTECTIVE CLOTHING.
For detailed information please refer to the respective Material Safety Data Sheet of the product!
MACHEREY-NAGEL products shall exclusively be used in an ADEQUATE TEST ENVIRONMENT.
MACHEREY-NAGEL does not assume any responsibility for damages due to improper application of our products in other
fields of application.
Application on the human body is STRICTLY FORBIDDEN. The respective user is liable for any and all damages resulting
from such application.
DNA / RNA / PROTEIN purification products of MACHEREY-NAGEL are suitable for IN-VITRO-USES ONLY! ONLY
MACHEREY-NAGEL products specially labeled as IVD are also suitable for IN-VITRO-diagnostic use. Please pay attention
to the package of the product. IN-VITRO-DIAGNOSTIC products are expressly marked as IVD on the packaging.
IF THERE IS NO IVD SIGN, THE PRODUCT SHALL NOT BE SUITABLE FOR IN-VITRO-DIAGNOSTIC USE!
ALL OTHER PRODUCTS NOT LABELED AS IVD ARE NOT SUITED FOR ANY CLINICAL USE (INCLUDING, BUT NOT
LIMITED TO DIAGNOSTIC, THERAPEUTIC, AND / OR PROGNOSTIC USE).
No claim or representations are intended for its use to identify any specific organism or for clinical use (included, but not
limited to diagnostic, prognostic, therapeutic, or blood banking). It is rather in the responsibility of the user or – in any case
of resale of the products – in the responsibility of the reseller to inspect and assure the use of the DNA/RNA/protein purification products of MACHEREY-NAGEL for a well-defined and specific application.
MACHEREY-NAGEL shall only be responsible for the product specifications and the performance range of MN products
according to the specifications of MN in-house quality control, product documentation, and marketing material.
For detailed information on product use restriction and warranty, please refer to the respective user manuals.
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15
Product use restriction
MACHEREY-NAGEL Bioanalysis products and their single components are intended, developed, designed, and sold FOR
RESEARCH PURPOSES ONLY, except, however, any other function of the product being expressly described in original
MACHEREY-NAGEL product leaflets.
DNA, RNA, and protein purification
Catalog supplement 2016
Service Bioanalysis
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KATEN300039 Catalog Supplement en3/8/0/08.2015
Printed in Germany
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MACHEREY-NAGEL
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MACHEREY-NAGEL GmbH & Co. KG · Neumann-Neander-Str. 6–8 · 52355 Düren · Germany
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