Anti-PSMD10 monoclonal antibody, clone 2C5
Cat.No: DCABH-13088
Lot. No. (See product label)
PRODUCT INFORMATION
Antigen Description
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed
of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 nonidentical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta
subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 nonATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are
distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitindependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the
immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase
subunit of the 19S regulator. Two transcripts encoding different isoforms have been described.
Pseudogenes have been identified on chromosomes 3 and 20.
Immunogen
PSMD10 (AAH11960, 127 a.a. ~ 226 a.a) partial recombinant protein with GST tag. MW of the GST
tag alone is 26 KDa.
Isotype
IgG1
Source/Host
Mouse
Species Reactivity
Human
Clone
2C5
Conjugate
Unconjugated
Applications
Western Blot (Recombinant protein); Sandwich ELISA (Recombinant protein); ELISA
Sequence Similarities
EGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQ
GASIYIENKEEKTPLQVAKGGLGLILKRMVEG
Size
1 ea
Buffer
In 1x PBS, pH 7.4
Storage
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Antigen Gene Information
Gene Name
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 [ Homo sapiens ]
Official Symbol
PSMD10
Synonyms
PSMD10; proteasome (prosome, macropain) 26S subunit, non-ATPase, 10; 26S proteasome nonATPase regulatory subunit 10; gankyrin; p28; ankyrin repeat protein; 26S proteasome regulatory
subunit p28; hepatocellular carcinoma-associated protein p28-II; p28(GANK); dJ889N15.2;
Entrez Gene ID
5716
mRNA Refseq
NM_002814
Protein Refseq
NP_002805
MIM
603480
Creative Diagnostics. All rights reserved
45-1 Ramsey Road Shirley, NY 11967, USA
Tel: 1-631-624-4882 Fax: 1-631-938-8221
E-mail: [email protected]
www.creative-diagnostics.com
1
UniProt ID
O75832
Chromosome Location Xq22.3
Pathway
APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem; APC/C:Cdc20
mediated degradation of Securin, organism-specific biosystem; APC/C:Cdc20 mediated degradation of
mitotic proteins, organism-specific biosystem; APC/C:Cdh1 mediated degradation of Cdc20 and other
APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystem; Activation of
APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem;
Activation of NF-kapp
Function
protein binding; transcription factor binding;
Creative Diagnostics. All rights reserved
45-1 Ramsey Road Shirley, NY 11967, USA
Tel: 1-631-624-4882 Fax: 1-631-938-8221
E-mail: [email protected]
www.creative-diagnostics.com
2