1/6/2012
Conference Sponsors
Post Traumatic Stress:
PTS Disorder
to
PTS Growth
Auburn University
Center for Governmental Services
November 3 - 4, 2011
Mobile, Alabama
Alabama Department of Mental Health
Alabama Department of Rehabilitation
Greenleaf
UAB School of Medicine
Conference Partners
Alabama National Guard
Alabama Department of Veterans Affairs
Alabama Department of Public Health
Alabama Department of Mental Health
Faculty
Healing:
Mind and Body
JoEllen Sefton, PhD, ATC, CMT
Co-Director
Warrior Research Center
Director
Warrior Athletic Training
g Program
g
Auburn University
Collaborations for Progress
Mission
Auburn
University
WRC
Military
Progress
Research
Veterans
• Assist the US Armed Forces in
improving individual warrior
physical, mental, and technical skill
performance in order to fight and win
in the 21st century battle space
Community
1
1/6/2012
Goals
• Improve overall mission readiness of
the Armed Forces and translate dual
use advances to the veteran and
civilian sector
• Reduce the number/severity of
injuries
Goals
• Improve equipment and training
methods
• Advance educational/training
strategies to improve
learning/leadership
• Improve rehabilitation/treatments
speeding return to duty
Goals
• Serve our Wounded Warriors and
Veterans with research, education,
and development
Healing: Mind
“Men and women are not prisoners
of fate, but only prisoners
of their own minds.”
– Franklin D.
D Roosevelt
Roose elt
Auburn MRI
Research Center
Auburn MRI
Research Center
• Structural scanning
• Biofeedback, EEG, etc.
• Real time fMRI
• Specialized coil development and
engineering
g
g expertise
p
• Diffusion tensor imaging
• Hyperscanning
• 3T and 7T or around the world
• Spectroscopy
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1/6/2012
Auburn MRI
Research Center
MRI Facility Overview
• MRI systems
– 3 Tesla (T) open-bore whole body
– 7T whole body
• Designed to support research and
clinical operations
– Clinical imaging center
– Laboratories
MRI Facility Overview
– Training facilities
– Distance course classrooms
– Human and animal facilities
MRI Facility
Overview - Design
• 7T Research
Imaging Area
MRI Facility
Overview - Design
• 3T Clinical and
Research
Imaging Area
MRI Facility
Overview - Design
• Wet labs, animal access, and housing
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1/6/2012
MRI Facility Overview – 3rd
Floor, Warrior Research Center
Spectroscopy
• Proton spectroscopy (3T and 7T)
– Single voxel
– Chemical shift imaging
• Multinuclear spectroscopy (7T only)
– 7Li, 13C, 17O, 19F, 23Na, 31P
Auburn Neurosurgery
Spectroscopy
Canine Olfactory fMRI
Cr
Cho
Cr
contrast(s)
<
<
1
[1.53323e-015, 25.0396, -1.52752]
olfac
NAA
50
100
<
SPM{F3,398 }
150
200
250
SPMresults:.\RenamedFiles\olfac_long
Height threshold F = 11.287583 {p<0.05 (FWE)}
Extent threshold k = 0 voxels
mI
300
350
400
1
2
3
Design m atrix
4
30
25
20
15
10
NAA Metabolite Map
Canine Olfactory fMRI
5
0
Canine Olfactory fMRI
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1/6/2012
Canine Olfactory fMRI
Post-traumatic
Stress Disorder
• Diagnosis
– Today: interviews, self-reporting
• Limitations
–Retrospective reporting
–Response bias: potential for
malingering
Post-traumatic
Stress Disorder
– Need for objective biological
indicators
• Imaging
g g
• Genomics/proteomics
• Tracking treatment
– Do potential therapies actually
work?
Basic Mechanisms of
Self-regulation
• Problem
– How are self-regulation constructs
arising from distinct approaches such
h as emotion
ti
regulation,
l ti
executive control, delay
discounting, impulsivity - related in
terms of the basic emotional,
cognitive, motivational and
neurobiological processes?
Post-traumatic
Stress Disorder
• Issues unique to the military
– Co-existing mild TBI and tinnitus
– Theater/trauma specific events
• Therapy
– Meditation
– Massage
– rTMS
Basic Mechanisms of
Self-regulation
• Purpose
– Develop a neuroimaging paradigm
which engages
g g all the distinct
approaches to self-regulation and
integrate the results
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1/6/2012
Basic Mechanisms of
Self-regulation
• Plan
– Perform fMRI experiments on
pp
above approaches
– Identify common brain areas
involved
– Provide a conceptual framework
for integration
Basic Mechanisms of
Self-regulation
• Impact
– Self-regulation is central to
p
y
p
g
psychiatric
pathologies
and
addiction
– The outcomes will help optimize
experimental designs for studying
self-regulation
Mental Skills Foundations
PIs: Gopikrishna Deshpande (AU-Eng), Ana Franco-Watkins (AU-Psych), Richard Mattson (AU-Psych)
Mental Skills Foundations
• PTSD, attention control – mind/body
connection
• CSF=PREP – army resiliency training
– Attention control – better able to
heal
Wounded Warriors
and Veterans
• Contributing to confidence and a
belief in one’s self contributes
significantly to the Warrior’s return
to duty, lower depression, higher
self-esteem, employment after injury,
healing, and successful return to a
productive and happy life
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1/6/2012
Stress Fracture Prevention
and Treatment
Warrior Athletic
Training Program
• Sports medicine care and research
Collaborations = Progress
Auburn
University
WRC
Military
Progress
Research
Veterans
Community
7